CD38-mediated growth suppression of B-cell progenitors requires activation of phosphatidylinositol 3-kinase and involves its association with the protein product of the c-cbl proto-oncogene

Blood

Volumn 88, Issue 2, 1996, Pages 590-598

  Kitanaka, Akira ^a   Ito, Chikako ^b   Nishigaki, Hikari ^b   Campana, Dario ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; B LYMPHOCYTE; CELL CYCLE; GROWTH INHIBITION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LYMPHOPOIESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0029906342     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.2.590.bloodjournal882590     Document Type: Article

References (46)

1. Stamenkovic I, Stauton J, Seed B: Molecular cloning of CD38, in Knapp W, Dorken B, Gilks WR, Rieber EP, Schmidt RE, Stein H, Von dem Borne AEGKr (eds): Leucocyte Typing IV. Oxford, UK, Oxford, 1989, p 87
2. Jackson DG, Bell JI: Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol 144:2811, 1990
3. Reinherz EL, Kung PC, Goldstein G, Levey RH, Schlossman SF: Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci USA 77:1588, 1980
4. Janossy G, Tidman N, Papageorgiou S, Kung PC, Goldstein G: Distribution of T lymphocyte subsets in the human bone marrow and thymus: An analysis with monoclonal antibodies. J Immunol 126:1608, 1981
5. Sieff C, Bicknell D, Caine G, Robinson J, Lam G, Greaves MF: Changes in cell surface antigen expression during hemopoietic differentiation. Blood 60:703, 1982
6. Funaro A, Spagnoli GC, Ausiello CM, Alessio M, Roggero S, Delia D, Zaccolo M, Malavasi F: Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation. J Immunol 145:2390, 1990
7. Kumagai M, Coustan-Smith E, Murry DJ, Silvennoinen O, Murti KG, Evans WE, Malavasi F, Campana D: Ligation of CD38 suppresses human B lymphopoiesis. J Exp Med 181:1101, 1995
8. Howard M, Grimaldi JC, Bazan JF, Lund FE, Santos-Argumedo L, Parkhouse RME, Walseth TF, Lee HC: Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38. Science 262:1056, 1993
9. Silvennoinen O, Nishigaki H, Kitanaka A, Kumagai M, Ito C, Malavasi F, Lin Q, Conley ME, Campana D: CD38 signal transduction in human B-cell precursors: Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-γ and phosphatydilinositol 3-kinase. J Immunol 156:100, 1996
10. Fry MJ: Structure, regulation and function of phosphoinositide 3-kinases. Biochem Biophys Acta 1226:237, 1994
11. Divecha N, Irvine RF: Phospholipid signaling. Cell 80:269, 1995
12. Yao R, Cooper GM: Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003, 1995
13. Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K, Fukui Y: Neunte outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269:18961, 1994
14. cbl in antigen receptor-ligated B cells. J Biol Chem 270:27504, 1995
15. Donovan JA, Wange RL, Langdon WY, Samelson LE: The protein product of the c-cbl protooncogene is the 120-kDa tyrosinephosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem 269:22921, 1994
16. Vlahos CJ, Matter WF, Hui KY, Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase 2-(4-morpholiny1)-8-pheny1-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241, 1994
17. Manabe A, Coustan-Smith E, Kumagai M, Behm FG, Raimondi SC, Pui C-H, Campana D: Interleukin-4 induces programmed cell death (apoptosis) in cases of high risk acute lymphoblastic leukemia. Blood 83:1731, 1994
18. Kumagai M, Manabe A, Pui C-H, Behm FG, Raimondi SC, Hancock ML, Mahmoud H, Crist WM, Campana D: Growth of childhood B-lineage acute lymphoblastic leukemia cells on bone marrow stroma as a predictor of treatment outcome. J Clin Invest 97:755, 1996
19. Whitman M, Kaplan DR, Schaffhausen B, Cantley L, Roberts TM: Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature 315:239, 1985
20. Cory GOC, Lovering RC, Hinshelwood S, MacCarthy-Morrogh L, Levinsky RJ, Kinnon C: The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase. J Exp Med 182:611, 1995
21. Meisner H, Conway BR, Hartley D, Czech MP: Interactions of cbl with grb2 and phosphatidylinositol 3′-kinase in activated Jurkat cells. Mol Cell Biol 15:3571, 1995
22. Rivero-Lezcano OM, Sameshima JA, Marcilla A, Robbins KC: Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem 269:17363, 1994
23. Hartley D, Meisner H, Corvera S: Specific association of the B isoform of the p85 subunit of phosphatydilinositol-3 kinase with the proto-oncogene c-cbl. J Biol Chem 270:18260, 1995
24. Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley LC, Shoelson SE, Band H: The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol-3-kinase. J Biol Chem 270:19141, 1995
25. Meisner H, Czech MP: Coupling of the proto-oncogene product c-cbl to the epidermal growth factor receptor. J Biol Chem 270:25332, 1995
26. Marcilla A, Rivero-Lezcano OM, Agarwal A, Robbins KC: Identification of the major tyrosine kinase substrate in signaling complexes formed after engagement of the Fcγ receptors. J Biol Chem 270:9115, 1995
27. Tanaka S, Neff L, Baron R, Levy JB: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem 270:14347, 1995
28. Carpenter CL, Cantley LC: Phosphoinositide kinases. Biochemistry 29:11147, 1990
29. Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonmura Y, Matsuda Y: Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846, 1993
30. Ui M, Okada T, Hazeki K, Hazeki O: Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biol Sci 20:303, 1995
31. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902, 1994
32. s6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370:71, 1994
33. Chung J, Kuo CJ, Crabtree GR, Blenis J: Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinase. Cell 69:1227, 1992
34. Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE: Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973, 1992
35. Scheuermann RH, Uhr JW: Connections between signal transduction components and cellular responses initiated by antigen receptor on B lymphocytes. J Exp Med 182:903, 1995
36. Blake TJ, Heath KG, Langdon WY: The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J 12:2017, 1993
37. Blake TJ, Shapiro M, Morse HC III, Langdon WY: The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6:653, 1991
38. Andoniou CE, Tien CBF, Langdon WY: Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J 13:4515, 1994
39. Kontani K, Kukimoto I, Nishina H, Hoshino S, Hazeki O, Kanako Y, Hatada T: Tyrosine phosphorylation of the c-cbl protooncogene product mediated by cell surface antigen CD38 in HL-60 cells. J Biol Chem 271:1534, 1996
40. Beckwith M, Fenton RG, Katona IM, Longo DL: Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line. Blood 87:2020, 1996
41. 3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell 83:821, 1995
42. Funaro A, De Monte LB, Dianziani U, Forni M, Malavasi F: Human CD38 is associated to distinct molecules which mediate transmembrane signaling in different lineages. Eur J Immunol 23:2407, 1993
43. Koehler M, Behm F, Hancock M, Pui C-H: Expression of activation antigens CD38 and CD71 is not clinically important in childhood acute lymphoblastic leukemia. Leukemia 7:41, 1993
44. Ellis JH, Barber KA, Tutt A, Hale C, Lewis AP, Glennie MJ, Stevenson GT, Crowe JS: Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma. J Immunol 155:925, 1995
45. - hematopoietic stem cells. Blood 83:1515, 1994
46. Craig W, Kay R, Cutler RL, Lansdorp PM: Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 177:1331, 1993