Roles of the JAK STAT system in signal transduction via cytokine receptors

Current Opinion in Genetics and Development

Volumn 6, Issue 5, 1996, Pages 587-596

  Watanabe, Sumiko ^a   Arai, Ken ichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERFERON;

CELL GROWTH; GENE INDUCTION; GROWTH REGULATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030272581     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(96)80088-8     Document Type: Article

References (54)

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31. Gobert S, Chretien S, Gouilleux F, Muller O, Pallard C, Dusanter-Fourt I, Groner B, Lacombe C, Gisselbrecht S, Mayeux P. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J. 15:1996;2434-2441.
32. Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JTE, Schreiber RD, Schindler CW, Krolewski JJ. Phosphorylated interferon-α receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15:1996;1064-1074.
33. Lin J-X, Migone T-S, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. of special interest Immunity. 2:1995;331-339 The γc subunit is shared by several cytokine receptors, yet JAK and STAT activated by these cytokines are not the same. After extensive analyses to understand this redundancy and pleiotropy, the authors found that there is a correlation between receptor motifs and activated STATs. This type of study may also provide information regarding redundancy and pleiotropy of the gp130-related cytokine system.
34. Cao X, Tay A, Guy G, Tan YH. Activation and association of Stat3 with Src in v-Src-transformed cell lines. of special interest Mol Cell Biol. 16:1996;1595-1603 The role of JAK on STAT phosphorylation has become a widely accepted dogma. This study demonstrates the possibility that phosphorylation or activation of STAT may occur via Src tyrosine kinase. This study also implicates the role of STAT in transformation.
35. Yu CL, Meyer DJ, Campbell GS, Lamar AC, Carter-Su C, Schwartz J, Jove R. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. of special interest Science. 269:1995;81-83 This paper has a conclusion similar to that of [34]. The authors suggest an indirect mechanism for the interaction of Src and STAT because they observe JAK activation in Src transformed cells.
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44. Meraz MA, White JM, Sheehan KCF, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the Jak-Stat signaling pathway. of special interest Cell. 84:1996;431-442 The authors here and in [45] arrive at the same conclusion that STAT1 is essential for IFNα/b and IFNγ signaling but not for other cytokines, such as IL-10, GH and EGF, which are known to activate STAT1.
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