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Volumn 5, Issue 1, 2001, Pages 59-86

Ion channels involved in stroke

Author keywords

apoptosis; calcium channels; cerebral ischaemia; excitotoxicity; GABA receptors; glutamate receptors; ion channels; metabotropic glutamate receptors; neuronal death; potassium channels; sodium channels

Indexed keywords


EID: 0009902065     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.5.1.59     Document Type: Review
Times cited : (2)

References (281)
  • 1
    • 0030851522 scopus 로고    scopus 로고
    • Poptosisinduced via AMPA-selective glutamate receptors in cultured murine cortical neurons
    • LARMJA, CHEUNG NS, BEARTPM:Apoptosisinduced via AMPA-selective glutamate receptors in cultured murine cortical neurons. J. Neurochem. (1997) 69:617-622.
    • (1997) J. Neurochem. , vol.69 , pp. 617-622
    • Larm, J.A.1    Cheung, N.S.2    Beart, P.M.3
  • 2
    • 0031570787 scopus 로고    scopus 로고
    • Glutamate-treated rat cortical neuronal cultures die in away different from the classical apoptosis induced by staurosporine
    • MACMANUS JP, RASQUINHA I, BLACK MA et al.: Glutamate-treated rat cortical neuronal cultures die in away different from the classical apoptosis induced by staurosporine. Exp. Cell. Res. (1997) 233:310-320.
    • (1997) Exp. Cell. Res. , vol.233 , pp. 310-320
    • MacManus, J.P.1    Rasquinha, I.2    Black, M.A.3
  • 3
    • 0029048295 scopus 로고
    • Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro
    • GWAG BJ, LOBNER D, KOH JY, WIE MB, CHOI DW: Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro. Neuroscience (1995) 68:615-619.
    • (1995) Neuroscience , vol.68 , pp. 615-619
    • Gwag, B.J.1    Lobner, D.2    Koh, J.Y.3    Wie, M.B.4    Choi, D.W.5
  • 4
    • 0032191207 scopus 로고    scopus 로고
    • Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones
    • CHEUNG NS, PASCOE CJ, GIARDINA SF, JOHN CA, BEART PM: Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones. Neuropharmacology (1998) 37:1419-1429.
    • (1998) Neuropharmacology , vol.37 , pp. 1419-1429
    • Cheung, N.S.1    Pascoe, C.J.2    Giardina, S.F.3    John, C.A.4    Beart, P.M.5
  • 5
    • 0028902855 scopus 로고
    • Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation
    • STRASSER U, FISCHER G: Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation. J. Neurosci. Meth. (1995) 57:177-186.
    • (1995) J. Neurosci. Meth. , vol.57 , pp. 177-186
    • Strasser, U.1    Fischer, G.2
  • 6
    • 0018347695 scopus 로고
    • Anew model of bilateral hemispheric ischemia in the unanesthetized rat
    • PULSINELLI WA, BRIERLEY JB: Anew model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke (1979) 10:267-272.
    • (1979) Stroke , vol.10 , pp. 267-272
    • Pulsinelli, W.A.1    Brierley, J.B.2
  • 7
    • 0021244677 scopus 로고
    • Models for studying long term recovery following forebrain ischemia in the rat. A 2-vessel occlusion model
    • SMITH ML, VON HANWEHR R, SIESJO BK: Models for studying long term recovery following forebrain ischemia in the rat. A 2-vessel occlusion model. Acta Neurol. Scand. (1984) 69:385-401.
    • (1984) Acta Neurol. Scand. , vol.69 , pp. 385-401
    • Smith, M.L.1    Von Hanwehr, R.2    Siesjo, B.K.3
  • 8
    • 0030635707 scopus 로고    scopus 로고
    • Techniques for examining neuroprotective drugs in vivo
    • GREEN AR, CROSS AJ: Techniques for examining neuroprotective drugs in vivo. Int. Rev. Neurobiol. (1997) 40:47-68.
    • (1997) Int. Rev. Neurobiol. , vol.40 , pp. 47-68
    • Green, A.R.1    Cross, A.J.2
  • 9
    • 0032507585 scopus 로고    scopus 로고
    • Differences in the cerebrovascular anatomy of C57black/6 and SV129 mice
    • MAEDA K, HATA R, HOSSMANN KA: Differences in the cerebrovascular anatomy of C57black/6 and SV129 mice. Neuroreport (1998) 9:1217-1219.
    • (1998) Neuroreport , vol.9 , pp. 1217-1219
    • Maeda, K.1    Hata, R.2    Hossmann, K.A.3
  • 10
    • 0030770634 scopus 로고    scopus 로고
    • Strain related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice
    • FUJII M, HARA H, MENG W, VONSATTEL JP, HUANG Z, MOSKOWITZ MA: Strain related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke (1997) 28:1805-1810.
    • (1997) Stroke , vol.28 , pp. 1805-1810
    • Fujii, M.1    Hara, H.2    Meng, W.3    Vonsattel, J.P.4    Huang, Z.5    Moskowitz, M.A.6
  • 13
    • 0023801585 scopus 로고
    • The quantification of cerebral infarction following focal ischemia in the rat: Influence of strain, arterial pressure, blood glucose concentration and age
    • DUVERGER D, MACKENZIE ET: The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration and age. J. Cereb. Blood Flow Metab. (1988) 8:449-461.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 449-461
    • Duverger, D.1    MacKenzie, E.T.2
  • 14
    • 0014937190 scopus 로고
    • Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine
    • OLNEY JW, HO OL: Brain damage in infant mice following oral intake of glutamate, aspartate or cysteine. Nature (1970) 227:609-611.
    • (1970) Nature , vol.227 , pp. 609-611
    • Olney, J.W.1    Ol, H.O.2
  • 15
    • 0019502281 scopus 로고
    • Kainic acid and other excitotoxins: A comparative analysis
    • OLNEY JW: Kainic acid and other excitotoxins: a comparative analysis. Adv. Biochem. Psychopharmacol. (1981) 27:375-384.
    • (1981) Adv. Biochem. Psychopharmacol. , vol.27 , pp. 375-384
    • Olney, J.W.1
  • 16
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclindine and related drugs
    • OLNEY JW, LABRUYERE J, PRICE MT: Pathological changes induced in cerebrocortical neurons by phencyclindine and related drugs. Science (1989) 244:1360-1362.
    • (1989) Science , vol.244 , pp. 1360-1362
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 17
    • 0034069630 scopus 로고    scopus 로고
    • Temporal profile of cytochrome c and caspase-3 immunoreactivities and TUNEL staining after permanent middle cerebral artery occlusion in rats
    • SASAKI C, KITAGAWA H, ZHANG WR, WARITA H, SAKAI K, ABE K: Temporal profile of cytochrome c and caspase-3 immunoreactivities and TUNEL staining after permanent middle cerebral artery occlusion in rats. Neurol. Res. (2000) 22:223-228.
    • (2000) Neurol. Res. , vol.22 , pp. 223-228
    • Sasaki, C.1    Kitagawa, H.2    Zhang, W.R.3    Warita, H.4    Sakai, K.5    Abe, K.6
  • 18
    • 0033782416 scopus 로고    scopus 로고
    • Apoptosis after experi mental stroke: Fact or fashion?
    • MACMANUS JP, BUCHAN AM: Apoptosis after experi mental stroke: fact or fashion? J. Neurotrauma (2000) 17:899-914.
    • (2000) J. Neurotrauma , vol.17 , pp. 899-914
    • MacManus, J.P.1    Buchan, A.M.2
  • 19
    • 0021707433 scopus 로고
    • Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
    • BENVENISTEH, DREJERJ, SCHOUSBOEAetal: Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem.(1984) 43:1369-1374.
    • (1984) J. Neurochem. , vol.43 , pp. 1369-1374
    • Benvenist, E.H.1    Dreje, R.J.2    Schousbo, E.A.3
  • 21
    • 0033765902 scopus 로고    scopus 로고
    • Novel neurotransmitters and their neuropsychiatric relevance
    • SNYDER SH, FERRIS CD: Novel neurotransmitters and their neuropsychiatric relevance. Am. J. Psychiatry (2000) 157:1738-1751.
    • (2000) Am. J. Psychiatry , vol.157 , pp. 1738-1751
    • Snyder, S.H.1    Ferris, C.D.2
  • 22
    • 0001945122 scopus 로고
    • Subtypes of glutamate receptors: Pharmacological classification
    • Stone TW (Ed.), CRC Press, Bocat Raton, FL.USA
    • HARRIS EW: Subtypes of glutamate receptors: pharmacological classification. In: CNS Neurotransmitters and Neuromodulators Glutamate. Stone TW (Ed.), CRC Press, Bocat Raton, FL.USA (1995).
    • (1995) CNS Neurotransmitters and Neuromodulators Glutamate
    • Harris, E.W.1
  • 23
    • 33845189959 scopus 로고    scopus 로고
    • NMDA antagonists: Their role in neuroprotection
    • SMALL DL, BUCHAN AM: NMDA antagonists: their role in neuroprotection. Int. Rev. Neurobiol. (1997) 40:137-171.
    • (1997) Int. Rev. Neurobiol. , vol.40 , pp. 137-171
    • Small, D.L.1    Buchan, A.M.2
  • 25
    • 0027176541 scopus 로고
    • Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3-benzodiazepines
    • ROGAWSKI MA: Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol. Sci. (1993) 14:325-331.
    • (1993) Trends Pharmacol. Sci. , vol.14 , pp. 325-331
    • Rogawski, M.A.1
  • 26
    • 0025309389 scopus 로고
    • N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism
    • SIMON R, SHIRAISHI K: N-methyl-D-aspartate antagonist reduces stroke size and regional glucose metabolism. Ann. Neurol. (1990) 27:606-611.
    • (1990) Ann. Neurol. , vol.27 , pp. 606-611
    • Simon, R.1    Shiraishi, K.2
  • 27
    • 0025992317 scopus 로고
    • The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pHin focal ischemia
    • TAKIZAWA S, HOGAN M, HAKIM AM: The effects of a competitive NMDA receptor antagonist (CGS-19755) on cerebral blood flow and pHin focal ischemia. J. Cereb. Blood Flow Metab. (1991) 11:786-793.
    • (1991) J. Cereb. Blood Flow Metab. , vol.11 , pp. 786-793
    • Takizawa, S.1    Hogan, M.2    Hakim, A.M.3
  • 28
    • 0027310151 scopus 로고
    • Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP 40116 in a rat model of focal cerebral ischemia: An in vitro magnetic resonance imaging study
    • SAUER D, ALLEGRINI PR, COSENTI A, PATAKI A, AMACKER H, FAGG GE: Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP 40116 in a rat model of focal cerebral ischemia: An in vitro magnetic resonance imaging study. J. Cereb. Blood Flow Metab. (1993) 13:595-602.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 595-602
    • Sauer, D.1    Allegrini, P.R.2    Cosenti, A.3    Pataki, A.4    Amacker, H.5    Fagg, G.E.6
  • 29
    • 0028170905 scopus 로고
    • The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia
    • SAUER D, ALLEGRINI PR, FAGG GE: The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia. J. Neural Transm. (1994) 43:81-89.
    • (1994) J. Neural Transm. , vol.43 , pp. 81-89
    • Sauer, D.1    Allegrini, P.R.2    Fagg, G.E.3
  • 30
    • 0023856682 scopus 로고
    • The N-methyl-D-aspartate antagonists CGS 19755 and CPPreduce ischemic brain damage in gerbils
    • BOAST CA, GERHARDT SC, PASTOR G, LEHMANN J, ETIENNE PE, LIEBMAN JM: The N-methyl-D-aspartate antagonists CGS 19755 and CPPreduce ischemic brain damage in gerbils. Brain Res. (1988) 442:345-348.
    • (1988) Brain Res. , vol.442 , pp. 345-348
    • Boast, C.A.1    Gerhardt, S.C.2    Pastor, G.3    Lehmann, J.4    Etienne, P.E.5    Liebman, J.M.6
  • 31
    • 0025351198 scopus 로고
    • CGS-19755,a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia
    • GROTTAJC, PICONE CM, OSTROW PTetal: CGS-19755,a competitive NMDA receptor antagonist, reduces calcium-calmodulin binding and improves outcome after global cerebral ischemia. Ann. Neurol. (1990) 27:612-619.
    • (1990) Ann. Neurol. , vol.27 , pp. 612-619
    • Grotta, J.C.1    Picone, C.M.2    Ostrow, P.T.3
  • 32
    • 0028337577 scopus 로고
    • The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke
    • HASEGAWA Y, FISHER M, BARON BM, METCALF G: The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke. Stroke (1994) 25:967-973.
    • (1994) Stroke , vol.25 , pp. 967-973
    • Hasegawa, Y.1    Fisher, M.2    Baron, B.M.3    Metcalf, G.4
  • 33
    • 0027157628 scopus 로고
    • Aurintricarboxylic acid protects hippocampal neurons from NMDA-and ischemia-induced toxicity invivo
    • ROBERTS-LEWIS JM, MARCY VR, YONGHUA Z, VAUGHT JL, SIMAN R, LEWIS ME: Aurintricarboxylic acid protects hippocampal neurons from NMDA-and ischemia-induced toxicity invivo. J.Neurochem. (1993) 61:378-381.
    • (1993) J. Neurochem. , vol.61 , pp. 378-381
    • Roberts-Lewis, J.M.1    Marcy, V.R.2    Yonghua, Z.3    Vaught, J.L.4    Siman, R.5    Lewis, M.E.6
  • 34
    • 0025142948 scopus 로고
    • Focal cerebral ischemia in the cat: Pretreatment with a competitive NMDA receptor antagonist, D-CPPene
    • BULLOCH R, GRAHAM DI, CHEN MH, LOW D, MCCULLOCH J: Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPPene.J. Cereb. Blood Flow Metab. (1990a) 10:668-674.
    • (1990) J. Cereb. Blood Flow Metab. , vol.10 , pp. 668-674
    • Bulloch, R.1    Graham, D.I.2    Chen, M.H.3    Low, D.4    McCulloch, J.5
  • 36
    • 0000942415 scopus 로고
    • D-CPPene (SDZEAA494), a competitive NMDA antagonist: Results from animal models and first results in humans
    • HERRLING PL: D-CPPene (SDZEAA494), a competitive NMDA antagonist: results from animal models and first results in humans. Neuropharmacology (1994) 10:S591.
    • (1994) Neuropharmacology , vol.10
    • Herrling, P.L.1
  • 37
    • 0028980761 scopus 로고
    • The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats
    • SAUER D, WEBER E, LUOND G, DASILVA F, ALLEGRINI PR: The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats. J. Cereb. Blood Flow Metab. (1995) 15:602-610.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 602-610
    • Sauer, D.1    Weber, E.2    Luond, G.3    Dasilva, F.4    Allegrini, P.R.5
  • 38
    • 0024409273 scopus 로고
    • Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist
    • FERKANYJW, KYLEDJ, WILLETS J et al: Pharmacological profile of NPC 12626, a novel, competitive N-methyl-D-aspartate receptor antagonist. J. Pharmacol. Exp. Ther. (1989) 250:100-109.
    • (1989) J. Pharmacol. Exp. Ther. , vol.250 , pp. 100-109
    • Ferkany, J.W.1    Kyled, J.2    Willets, J.3
  • 39
    • 0028032883 scopus 로고
    • Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats
    • NISHIKAWA T, KIRSCH JR, KOEHLER RC, MIYABE M, TRAYSTMAN RJ: Competitive N-methyl-D-aspartate receptor blockade reduces brain injury following transient focal ischemia in cats. Stroke (1994) 25:2258-2264.
    • (1994) Stroke , vol.25 , pp. 2258-2264
    • Nishikawa, T.1    Kirsch, J.R.2    Koehler, R.C.3    Miyabe, M.4    Traystman, R.J.5
  • 40
    • 0024386187 scopus 로고
    • The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury
    • ROMAN R, BARTKOWSKI H, SIMON R: The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury. Neurosci. Lett. (1989) 104:19-24.
    • (1989) Neurosci. Lett. , vol.104 , pp. 19-24
    • Roman, R.1    Bartkowski, H.2    Simon, R.3
  • 41
    • 0023841304 scopus 로고
    • Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia
    • SWAN JH, EVANS, MC, MELDRUM BS: Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia. J. Cereb. Blood Flow Metab. (1988) 8:64-78.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 64-78
    • Swan, J.H.1    Evans, M.C.2    Meldrum, B.S.3
  • 42
    • 0002170907 scopus 로고
    • N-methyl-D-aspartate receptor antagonists: Failure to prevent ischemia-induced selective neuronal damage
    • ME Raichle WJ Powers (Eds) Raven Press, New York, USA
    • BLOCK GA, PULSINELLI WA: N-methyl-D-aspartate receptor antagonists: failure to prevent ischemia-induced selective neuronal damage. In: Cerebrovascular Diseases. ME Raichle WJ Powers (Eds). Raven Press, New York, USA (1987):37-42.
    • (1987) Cerebrovascular Diseases , pp. 37-42
    • Block, G.A.1    Pulsinelli, W.A.2
  • 43
    • 0024511941 scopus 로고
    • Intraventricular infusion of 2-amino-7-phosphonoheptanoate (APH) mitigates ischaemic brain damage
    • JENSEN ML, AUER RN: Intraventricular infusion of 2-amino-7- phosphonoheptanoate (APH) mitigates ischaemic brain damage. Neurol. Res. (1989)11:37-40.
    • (1989) Neurol. Res. , vol.11 , pp. 37-40
    • Jensen, M.L.1    Auer, R.N.2
  • 44
    • 0021743001 scopus 로고
    • Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain
    • SIMON RP, SWAN JH, GRIFFITHS T, MELDRUM BS: Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science (1984) 226:850-852.
    • (1984) Science , vol.226 , pp. 850-852
    • Simon, R.P.1    Swan, J.H.2    Griffiths, T.3    Meldrum, B.S.4
  • 45
    • 0001280792 scopus 로고
    • Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex
    • FAVARON M, MANEV H, ALHO H et al: Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proc. Natl. Acad. Sci. USA(1988) 85:7351-7355.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 7351-7355
    • Favaron, M.1    Manev, H.2    Alho, H.3
  • 46
    • 0023873505 scopus 로고
    • Protective effect of the glutamate antagonist, MK-801, in focal cerebral ischemia in the cat
    • OZYURTE, GRAHAM DI, WOODRUFF GN, MCCULLOCH J: Protective effect of the glutamate antagonist, MK-801, in focal cerebral ischemia in the cat.J. Cereb. Blood Flow Metab. (1988) 8:138-143.
    • (1988) J Cereb. Blood Flow Metab. , vol.8 , pp. 138-143
    • Ozyur, T.E.1    Graham, D.I.2    Woodruff, G.N.3    McCulloch, J.4
  • 47
    • 0023788688 scopus 로고
    • The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat
    • PARK CK, NEHLS DG, GRAHAM DI, TEASDALE GM, MCCULLOCH J: The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann. Neurol. (1988a) 24:543-551.
    • (1988) Ann. Neurol. , vol.24 , pp. 543-551
    • Park, C.K.1    Nehls, D.G.2    Graham, D.I.3    Teasdale, G.M.4    McCulloch, J.5
  • 48
    • 0023694129 scopus 로고
    • Focal cerebral ischaemia in the cat: Treatment with the glutamate antagonist MK-801 after induction of ischaemia
    • PARK CK, NEHLS DG, GRAHAM DI, TEASDALE GM, MCCULLOCH J: Focal cerebral ischaemia in the cat: treatment with the glutamate antagonist MK-801 after induction of ischaemia. J. Cereb. Blood Flow Metab. (1988b) 8:757-762.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 757-762
    • Park, C.K.1    Nehls, D.G.2    Graham, D.I.3    Teasdale, G.M.4    McCulloch, J.5
  • 49
    • 0025817573 scopus 로고
    • The effects of dizocilpine (MK-801), phencyclidine and nimodipine on infarct size 48 h after middle cerebral artery occlusion in the rat
    • BIELENBERG GW, BECK T: The effects of dizocilpine (MK-801), phencyclidine and nimodipine on infarct size 48 h after middle cerebral artery occlusion in the rat. Brain Res. (1991) 552:338-342.
    • (1991) Brain Res. , vol.552 , pp. 338-342
    • Bielenberg, G.W.1    Beck, T.2
  • 50
    • 0027980085 scopus 로고
    • Prolonged effects of MK-801 in the cat during focal cerebral ischemia and recovery: Survival, EEG activity and histopathology
    • DEZSI L, GREENBERG JH, SLADKY J, ARAKI N, HAMAR J, REIVICH M: Prolonged effects of MK-801 in the cat during focal cerebral ischemia and recovery: survival, EEG activity and histopathology. J. Neurol. Sci. (1994) 121:110-120.
    • (1994) J. Neurol. Sci. , vol.121 , pp. 110-120
    • Dezsi, L.1    Greenberg, J.H.2    Sladky, J.3    Araki, N.4    Hamar, J.5    Reivich, M.6
  • 51
    • 0024320193 scopus 로고
    • Neurologic and pathologic outcome after middle cerebral artery occlusion in rats
    • PERSSON L, HARDEMARK HG, BOLANDERHG, HILLERED L, OLSSON Y: Neurologic and pathologic outcome after middle cerebral artery occlusion in rats. Stroke (1989) 20:641-645.
    • (1989) Stroke , vol.20 , pp. 641-645
    • Persson, L.1    Hardemark, H.G.2    Bolander, H.G.3    Hillered, L.4    Olsson, Y.5
  • 52
    • 0006387685 scopus 로고
    • Effects of the noncompetitive NMDA receptor antagonist MK-801 on ischemic and hypoglycemic brain damage
    • Neurology and Neurobiology EA Cavalheiro, J Lehmann, L Turski (Eds.) , Liss, New York, USA
    • WIELOCH T, GUSTAFSSON I, WESTERBERG E: Effects of the noncompetitive NMDA receptor antagonist MK-801 on ischemic and hypoglycemic brain damage. In: Frontiers in Excitatory Amino Acid Research, Vol. 46, Neurology and Neurobiology EA Cavalheiro, J Lehmann, L Turski (Eds.), Liss, New York, USA (1988):715-722.
    • (1988) Frontiers in Excitatory Amino Acid Research , vol.46 , pp. 715-722
    • Wieloch, T.1    Gustafsson, I.2    Westerberg, E.3
  • 53
    • 0024326851 scopus 로고
    • MK-801, an excitatory amino acid antagonist, does not improve neurologic outcome following cardiac arrest in cats
    • FLEISCHER JE, TATEISHI A, DRUMMONDJC et al: MK-801, an excitatory amino acid antagonist, does not improve neurologic outcome following cardiac arrest in cats. J. Cereb. Blood Flow Metab. (1989) 9:795-804.
    • (1989) J. Cereb. Blood Flow Metab. , vol.9 , pp. 795-804
    • Fleischer, J.E.1    Tateishi, A.2    Drummond, J.C.3
  • 54
    • 0025012714 scopus 로고
    • Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia
    • BUCHAN AM, PULSINELLI WA: Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J. Neurosci. (1990) 10:311-316.
    • (1990) J. Neurosci. , vol.10 , pp. 311-316
    • Buchan, A.M.1    Pulsinelli, W.A.2
  • 55
    • 0025248462 scopus 로고
    • The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurological recovery and histopathology following complete cerebral ischemia in primates
    • LANIER WL, PERKINS WJ, KARLSSON BR et al: The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurological recovery and histopathology following complete cerebral ischemia in primates. J. Cereb. Blood Flow Metab. (1990) 10:252-261.
    • (1990) J. Cereb. Blood Flow Metab. , vol.10 , pp. 252-261
    • Lanier, W.L.1    Perkins, W.J.2    Karlsson, B.R.3
  • 56
    • 0023425239 scopus 로고
    • Sytemic admini stration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil
    • GILL R, FOSTER AC, WOODRUFF GN: Sytemic admini stration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J. Neurosci. (1987) 7:3343-3349.
    • (1987) J. Neurosci. , vol.7 , pp. 3343-3349
    • Gill, R.1    Foster, A.C.2    Woodruff, G.N.3
  • 57
    • 0023941585 scopus 로고
    • MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period
    • GILL R, FOSTER AC, WOODRUFF GN: MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period. Neuroscience (1988) 25:847-855.
    • (1988) Neuroscience , vol.25 , pp. 847-855
    • Gill, R.1    Foster, A.C.2    Woodruff, G.N.3
  • 58
    • 0023684627 scopus 로고
    • Phencyclidine reduces postischemic neuronal necrosis in rat hippocampus without changing blood flow
    • SAUER D, NUGLISCH J, ROSSBERG C: Phencyclidine reduces postischemic neuronal necrosis in rat hippocampus without changing blood flow. Neurosci. Lett. (1988) 91:327-332.
    • (1988) Neurosci. Lett. , vol.91 , pp. 327-332
    • Sauer, D.1    Nuglisch, J.2    Rossberg, C.3
  • 59
    • 0027474565 scopus 로고
    • Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion weighted MRI
    • MINEMATSU K, FISHER M, LI L et al.: Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion weighted MRI. Neurol. (1993) 43:397-403.
    • (1993) Neurol. , vol.43 , pp. 397-403
    • Minematsu, K.1    Fisher, M.2    I, L.L.3
  • 60
    • 0001324010 scopus 로고
    • Synthesis and characterization of a series of diarylgua-nidines that are noncompetitive N-methyl-D-aspartate recetor antagonists with neuroprotective properties
    • KEANNA JFW, MCBURNEY RN, SCHERZ MW et al.: Synthesis and characterization of a series of diarylgua-nidines that are noncompetitive N-methyl-D-aspartate recetor antagonists with neuroprotective properties. Proc. Natl. Acad. Sci. USA (1989) 86:5631-5635.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5631-5635
    • Jfw, K.1    McBurney, R.N.2    Scherz, M.W.3
  • 61
    • 4244030354 scopus 로고
    • The dose-dependency of the antiischemic efficacy and of the side effects of a novel NMDA antagonist CNS 1102
    • PARK CK, MCBURNEY RN, HOLT WF et al.: The dose-dependency of the antiischemic efficacy and of the side effects of a novel NMDA antagonist, CNS 1102. J. Cereb. Blood Flow Metab. (1993) 13 :S641.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13
    • Park, C.K.1    McBurney, R.N.2    Holt, W.F.3
  • 62
    • 8044248189 scopus 로고
    • Cerestat (CNS1102)-preliminary results in stroke and TBI patients
    • GAMZU ER, MCBURNEY R: Cerestat (CNS1102)-preliminary results in stroke and TBI patients. Neuropsychopharmacol. (1994) 10:S592.
    • (1994) Neuropsychopharmacol. , vol.10
    • Gamzu, E.R.1    McBurney, R.2
  • 63
    • 0028836150 scopus 로고
    • The neuroprotectiveeffectofthe novel noncompetitive NMDA antagonist, FR115427 in focal cerebral ischemia in rats
    • KATSUTA K, NAKANISHI H, SHIRAKAWA K, YOSHIDA K, TAKAGIK,TAMURAA: The neuroprotectiveeffectofthe novel noncompetitive NMDA antagonist, FR115427 in focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. (1995) 15:345-348.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 345-348
    • Katsuta, K.1    Nakanishi, H.2    Shirakawa, K.3    Yoshida, K.4    Takagiktamuraa5
  • 65
    • 0028834171 scopus 로고
    • In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists
    • WARNER DS, MARTIN H, LUDWIG P, MCALLISTER A, KEANA JFW, WEBER E: In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. J. Cereb. Blood Flow Metab. (1995) 15:188-196.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 188-196
    • Warner, D.S.1    Martin, H.2    Ludwig, P.3    McAllister, A.4    Jfw, K.5    Weber, E.6
  • 66
    • 0033403484 scopus 로고    scopus 로고
    • NPS 1506, a novel NMDA receptor antagonist and neuroprotectan Review of preclinical and clinical studies
    • MUELLER AL, ARTMAN LD, BALANDRIN MF et al.: NPS 1506, a novel NMDA receptor antagonist and neuroprotectant. Review of preclinical and clinical studies. Ann. NY Acad. Sci. (1999) 890:450-457.
    • (1999) Ann. NY Acad. Sci. , vol.890 , pp. 450-457
    • Mueller, A.L.1    Artman, L.D.2    Balandrin, M.F.3
  • 67
    • 33845195752 scopus 로고
    • Dextrorphan reduces infarct volume after middle cerebral occlusion in rats: A magnetic resonance imaging and histopathology study
    • KENT TA, EISENBERG H, QUAST M, ANDERSON A, HILLMAN G, CAMPBELL G: Dextrorphan reduces infarct volume after middle cerebral occlusion in rats: a magnetic resonance imaging and histopathology study. J. Cereb. Blood Flow Metab. (1989) 9:S153.
    • (1989) J. Cereb. Blood Flow Metab. , vol.9
    • Kent, T.A.1    Eisenberg, H.2    Quast, M.3    Anderson, A.4    Hillman, G.5    Campbell, G.6
  • 68
    • 0024414552 scopus 로고
    • Pretreatmentwiththe NMDAantagonist dextrorphan reduces cerebral injury after focal ischemia in rabbits
    • STEINBERG GK, SALEH J, DELAPAZ R, KUNIS D, ZARNEGAR SR: Pretreatmentwiththe NMDAantagonist dextrorphan reduces cerebral injury after focal ischemia in rabbits. Brain Res. (1989a) 497:382-386.
    • (1989) Brain Res. , vol.497 , pp. 382-386
    • Steinberg, G.K.1    Saleh, J.2    Delapaz, R.3    Kunis, D.4    Zarnegar, S.R.5
  • 69
    • 0024428827 scopus 로고
    • Protective effect of N-methyl-D-apspa-rtate antagonists after focal cerebral ischemia in rabbits
    • STEINBERG GK, SALEH J, KUNIS D, DELAPAZ R, ZARNEGAR SR: Protective effect of N-methyl-D-apspa-rtate antagonists after focal cerebral ischemia in rabbits. Stroke (1989b) 20:1247-1252.
    • (1989) Stroke , vol.20 , pp. 1247-1252
    • Steinberg, G.K.1    Saleh, J.2    Kunis, D.3    Delapaz, R.4    Zarnegar, S.R.5
  • 70
    • 0025261747 scopus 로고
    • Protection by NMDA antagonists against selective cell loss following transient ischaemia
    • SWAN JH, MELDRUM BS: Protection by NMDA antagonists against selective cell loss following transient ischaemia. J. Cereb. Blood Flow Metab. (1990) 10:343-351.
    • (1990) J. Cereb. Blood Flow Metab. , vol.10 , pp. 343-351
    • Swan, J.H.1    Meldrum, B.S.2
  • 71
    • 0027322854 scopus 로고
    • Neuronal protection and preservation of calcium/calmodulin-dependent protein kinase II and protein kinase C activity by dextrorphan treatment in global ischemia
    • ARONOWSKI J, WAXHAM MN, GROTTA JC: Neuronal protection and preservation of calcium/calmodulin-dependent protein kinase II and protein kinase C activity by dextrorphan treatment in global ischemia. J.Cereb. Blood Flow Metab. (1993) 13:550-557.
    • (1993) J.Cereb. Blood Flow Metab. , vol.13 , pp. 550-557
    • Aronowski, J.1    Waxham, M.N.2    Grotta, J.C.3
  • 72
    • 0023896462 scopus 로고
    • Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia
    • STEINBERG GK, SALEH J, KUNIS D: Delayed treatment with dextromethorphan and dextrorphan reduces cerebral damage after transient focal ischemia. Neurosci. Lett. (1988a) 89:193-197.
    • (1988) Neurosci. Lett. , vol.89 , pp. 193-197
    • Steinberg, G.K.1    Saleh, J.2    Kunis, D.3
  • 73
    • 0023805448 scopus 로고
    • Ketamine fails to protect against ischaemic neuronal necrosis in the rat
    • JENSEN MI, AUER RN: Ketamine fails to protect against ischaemic neuronal necrosis in the rat. Br. J. Anaesth. (1988) 61:206-210.
    • (1988) Br. J. Anaesth. , vol.61 , pp. 206-210
    • Jensen, M.I.1    Auer, R.N.2
  • 75
    • 0025351176 scopus 로고
    • Kyurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats
    • ROUSSEL S, PINARD E, SEYLAZ J: Kyurenate does not reduce infarct size after middle cerebral artery occlusion in spontaneously hypertensive rats. Brain Res. (1990) 518:353-355.
    • (1990) Brain Res. , vol.518 , pp. 353-355
    • Roussel, S.1    Pinard, E.2    Seylaz, J.3
  • 77
    • 0023682334 scopus 로고
    • Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits
    • STEINBERG GK, GEORGE CP, DELAPAZ R, SHIBATA DK, GROSS T: Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits. Stroke (1988b) 19:1112-1118.
    • (1988) Stroke , vol.19 , pp. 1112-1118
    • Steinberg, G.K.1    George, C.P.2    Delapaz, R.3    Shibata, D.K.4    Gross, T.5
  • 78
    • 0026564448 scopus 로고
    • Open channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity
    • CHEN HSV, PELLIGRINI JW, AGGARWAI SK et al.: Open channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J. Neurosci. (1992) 12:4427-4436.
    • (1992) J. Neurosci. , vol.12 , pp. 4427-4436
    • Hsv, C.1    Pelligrini, J.W.2    Aggarwai, S.K.3
  • 79
    • 0025801643 scopus 로고
    • Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate
    • ERDO SL, SCHAFER M: Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate. Eur. J. Pharmacol. (1991) 198:215-217.
    • (1991) Eur. J. Pharmacol. , vol.198 , pp. 215-217
    • Erdo, S.L.1    Schafer, M.2
  • 81
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • MUIR KW, LEES KR: Clinical experience with excitatory amino acid antagonist drugs. Stroke (1995) 26:503-513.
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 82
    • 0028135333 scopus 로고
    • Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat
    • BENNAN PE, GRAHAM DI, LEES KR, MCCULLOCH J: Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat. Brain Res. (1994) 664:271-275.
    • (1994) Brain Res. , vol.664 , pp. 271-275
    • Bennan, P.E.1    Graham, D.I.2    Lees, K.R.3    McCulloch, J.4
  • 84
    • 0002689576 scopus 로고
    • Pharmacological effects of remacemide and MK-801 on memory and hippocampal CA1 damage in the rat four-vessel occlusion (4-VO) model of global ischemia
    • MYT Globus, WD Dietrich (Eds.), Plenum Press, New York, USA
    • ORDY JM, VOLPE B, MURRAY R et al: Pharmacological effects of remacemide and MK-801 on memory and hippocampal CA1 damage in the rat four-vessel occlusion (4-VO) model of global ischemia. In: The Role of Neurotransmitters in Brain Injury. MYT Globus, WD Dietrich (Eds.), Plenum Press, New York, USA (1992):83-92.
    • (1992) The Role of Neurotransmitters in Brain Injury , pp. 83-92
    • Ordy, J.M.1    Volpe, B.2    Murray, R.3
  • 86
    • 0028834171 scopus 로고
    • In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists
    • WARNER DS, MARTIN H, LUDWIG P, MCALLISTER A, KEANA JFW, WEBER E: In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. J. Cereb. Blood Flow Metab. (1995) 15:188-196.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 188-196
    • Warner, D.S.1    Martin, H.2    Ludwig, P.3    McAllister, A.4    Jfw, K.5    Weber, E.6
  • 87
    • 80052100253 scopus 로고    scopus 로고
    • Glycine antagonists in neuroprotection-I (GAIN-I)
    • HALEY EC, JR: Glycine antagonists in neuroprotection-I (GAIN-I). Stroke (1997) 28:232.
    • (1997) Stroke , vol.28 , pp. 232
    • Haley Jr., E.C.1
  • 88
    • 0026562575 scopus 로고
    • Strychnine-insensitive glycine receptors in embryonic chick retina: Characteristics and modulation of NMDA of neurotoxicity
    • BOJE KM, SKOLNICK P, RABER J, FLETCHER RT, CHADER G Strychnine- insensitive glycine receptors in embryonic chick retina: characteristics and modulation of NMDA of neurotoxicity. Neurochem. Int. (1992) 20:473-450.
    • (1992) Neurochem. Int. , vol.20 , pp. 473-450
    • Boje, K.M.1    Skolnick, P.2    Raber, J.3    Fletcher, R.T.4    Chader, G.5
  • 90
  • 91
    • 0024268924 scopus 로고
    • Ifenprodil and SL 82.0715 as cerebral antiischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties
    • CARTER C, BENAVIDES J, LEGENDRE P et al: Ifenprodil and SL 82.0715 as cerebral antiischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.J.Pharmacol.Exp. Ther. (1988) 247:1222-1232.
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 1222-1232
    • Carter, C.1    Benavides, J.2    Legendre, P.3
  • 92
    • 0024235996 scopus 로고
    • Ifenprodil and SL 882.0715 as cerebral anti-ischaemic agents. I. Evidence for efficacy in models of focal cerebral ischaemia
    • GOTTI B, DUVERGER D, BURTIN D et al: Ifenprodil and SL 882.0715 as cerebral anti-ischaemic agents. I. Evidence for efficacy in models of focal cerebral ischaemia.J.Pharmacol.Exp. Ther. (1988) 247:1211-1221.
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 1211-1221
    • Gotti, B.1    Duverger, D.2    Burtin, D.3
  • 93
    • 0007097864 scopus 로고
    • CP-101, 606, a potent and selective antagonist of forebrain NMDA receptors: In vitro neuroprotective activity
    • MENNITI FS, COLLINS MA, CHENARD BL, SHALABY IA, WHITE WF: CP-101,606, a potent and selective antagonist of forebrain NMDA receptors: in vitro neuroprotective activity. Soc. Neurosci. Abstr. (1995) 21:37.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 37
    • Menniti, F.S.1    Collins, M.A.2    Chenard, B.L.3    Shalaby, I.A.4    White, W.F.5
  • 95
    • 0025779342 scopus 로고
    • Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia
    • BUCHAN AM, XUE D, HUANG ZG, SMITH KH, LESIUK H: Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia. NeuroReport (1991a) 2:473-476.
    • (1991) NeuroReport , vol.2 , pp. 473-476
    • Buchan, A.M.1    Xue, D.2    Huang, Z.G.3    Smith, K.H.4    Lesiuk, H.5
  • 96
    • 0028852625 scopus 로고
    • The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischaemia
    • GILL R, HARGREAVES RJ, KEMP JA: The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischaemia. J. Cereb. Blood Flow Metab. (1995) 15:197-204.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 197-204
    • Gill, R.1    Hargreaves, R.J.2    Kemp, J.A.3
  • 97
    • 0025117827 scopus 로고
    • 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischaemia
    • SHEARDOWN MJ, NIELSON EO, HANSEN AJ, JACOBSEN P, HONORE T: 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischaemia. Science (1990) 247:571-574.
    • (1990) Science , vol.247 , pp. 571-574
    • Sheardown, M.J.1    Nielson, E.O.2    Hansen, A.J.3    Jacobsen, P.4    Honore, T.5
  • 98
    • 0027336469 scopus 로고
    • AMPA, but not NMDA, receptor antagonist is neuroprotective in gerbil global ischaemia, even when delayed 24 h
    • SHEARDOWN MJ, SUZDAK PD, NORDHOLM L: AMPA, but not NMDA, receptor antagonist is neuroprotective in gerbil global ischaemia, even when delayed 24 h. Eur.J. Pharmacol. (1993) 236:347-353.
    • (1993) Eur. J. Pharmacol. , vol.236 , pp. 347-353
    • Sheardown, M.J.1    Suzdak, P.D.2    Nordholm, L.3
  • 99
    • 0012084409 scopus 로고
    • N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia
    • DIEMER NH, JOHANSEN FF, JORGENSEN MB: N-methyl-D-aspartate and non-N-methyl-D-aspartate antagonists in global cerebral ischemia. Stroke (1990) 21 :III39-III42.
    • (1990) Stroke , vol.21
    • Diemer, N.H.1    Johansen, F.F.2    Jorgensen, M.B.3
  • 100
    • 0026750123 scopus 로고
    • Protection against ischaemic hippocampal CA1 damage in the rat with a new non-NMDA antagonist, NBQX
    • DIEMER NH, JOHANSEN FF, JORGENSEN MB, SHEARDOWN M, HONORE T: Protection against ischaemic hippocampal CA1 damage in the rat with a new non-NMDA antagonist, NBQX. Acta Neurol. Scand. (1992) 86:45-49.
    • (1992) Acta Neurol. Scand. , vol.86 , pp. 45-49
    • Diemer, N.H.1    Johansen, F.F.2    Jorgensen, M.B.3    Sheardown, M.4    Honore, T.5
  • 101
    • 0025943535 scopus 로고
    • Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats
    • BUCHAN AM, LI H, CHO S, PULSINELLI WA: Blockade of the AMPA receptor prevents CA1 hippocampal injury following severe but transient forebrain ischemia in adult rats. Neurosci. Lett. (1991b) 132:255-258.
    • (1991) Neurosci. Lett. , vol.132 , pp. 255-258
    • Buchan, A.M.1    I, H.L.2    Cho, S.3    Pulsinelli, W.A.4
  • 102
    • 0026537712 scopus 로고
    • The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat
    • LE PEILLET E, ARVIN B, MONCADA C, MELDRUM BS: The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat. Brain Res. (1992) 571:115-120.
    • (1992) Brain Res. , vol.571 , pp. 115-120
    • Peillet, E.L.E.1    Arvin, B.2    Moncada, C.3    Meldrum, B.S.4
  • 103
    • 0026505401 scopus 로고
    • Postischaemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischaemia
    • NELLGARD B, WIELOCH T: Postischaemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischaemia. J. Cereb. Blood Flow Metab. (1992) 12:2-11.
    • (1992) J. Cereb. Blood Flow Metab. , vol.12 , pp. 2-11
    • Nellgard, B.1    Wieloch, T.2
  • 104
    • 4244062115 scopus 로고
    • Blockade of the AMPAreceptor beginning 8 hours after transient forebrain ischaemia attenuates CA1 hippocampal injury in rats
    • PULSINELLI WA, CHO S: Blockade of the AMPAreceptor beginning 8 hours after transient forebrain ischaemia attenuates CA1 hippocampal injury in rats. Neurology (1992) (Suppl. 3):532S.
    • (1992) Neurology , Issue.SUPPL. 3
    • Pulsinelli, W.A.1    Cho, S.2
  • 105
    • 0027445864 scopus 로고
    • Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury
    • LI H, BUCHAN AM: Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury. J. Cereb. Blood Flow Metab. (1993) 13:933-939.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 933-939
    • I, H.L.1    Buchan, A.M.2
  • 106
    • 0007358152 scopus 로고
    • Delayed treatment with the novel AMPAreceptor antagonist, PD152247 (PNQX), reduces lesion size following focal ischemia and reperfusion in the rat
    • SCHEILKE GP, KUPINA NC, BOXER PA, CORDON JJ, BIGGE CF, MARCOUX FW: Delayed treatment with the novel AMPAreceptor antagonist, PD152247 (PNQX), reduces lesion size following focal ischemia and reperfusion in the rat. J. Cereb. Blood Flow Metab. (1995) 15:S372.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15
    • Scheilke, G.P.1    Kupina, N.C.2    Boxer, P.A.3    Cordon, J.J.4    Bigge, C.F.5    Marcoux, F.W.6
  • 107
    • 0029746259 scopus 로고    scopus 로고
    • Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonists, in focal cerebral ischemia in cats
    • YATSUGI S, TAKAHASHI M, KAWASAKI-YATSUGI S et al.: Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonists, in focal cerebral ischemia in cats. J. Cereb. Blood Flow Metab. (1996) 16:959-966.
    • (1996) J. Cereb. Blood Flow Metab. , vol.16 , pp. 959-966
    • Yatsugi, S.1    Takahashi, M.2    Kawasaki-Yatsugi, S.3
  • 108
    • 0029927472 scopus 로고    scopus 로고
    • YM90K: Phamacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate kainate receptor antagonist
    • SHIMIZU-SASAMATA M, KAWASAKIYATSUGI S, OKADA M et al: YM90K: phamacological characterization as a selective and potent alpha-amino-3-hydroxy- 5-methylisoxazole-4-propionate kainate receptor antagonistJ. Pharmacol. Exp. Ther. (1996) 276:84-92.
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 84-92
    • Shimizu-Sasamata, M.1    Kawasakiyatsugi, S.2    Okada, M.3
  • 109
    • 0032543159 scopus 로고    scopus 로고
    • A novel AMPA receptor antagonist, YM872, reduces infarct size after middle cerebral artery occlusion in rats
    • KAWASAKI-YATSUGI S, YATSUGI S, TAKAHASHI M et al: A novel AMPA receptor antagonist, YM872, reduces infarct size after middle cerebral artery occlusion in rats. Brain Res. (1998) 793:39-46.
    • (1998) Brain Res. , vol.793 , pp. 39-46
    • Kawasaki-Yatsugi, S.1    Yatsugi, S.2    Takahashi, M.3
  • 110
    • 0033988426 scopus 로고    scopus 로고
    • Neuroprotective effects of an AMPAreceptor antagonist YM872 in a rat transient middle cerebral artery occlusion model
    • KAWASAKI-YATSUGI S, ICHIKI C, YATSUGI S et al: Neuroprotective effects of an AMPAreceptor antagonist YM872 in a rat transient middle cerebral artery occlusion model. Neuropharmacology (2000) 39:211-217.
    • (2000) Neuropharmacology , vol.39 , pp. 211-217
    • Kawasaki-Yatsugi, S.1    Ichiki, C.2    Yatsugi, S.3
  • 111
    • 0032465471 scopus 로고    scopus 로고
    • Neuroprotective efficacy of YM872, an alpha-amino-3-hydroxy-5- methylisoxazole-4-propionic acid receptor antagonist, after permanent middle cerebral artery occlusion in rats
    • TAKAHASHI M, NI JW, KAWASAKI-YATSUGI S et al: Neuroprotective efficacy of YM872, an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, after permanent middle cerebral artery occlusion in rats. J. Pharmacol. Exp. Ther. (1998) 287:559-566.
    • (1998) J. Pharmacol. Exp. Ther. , vol.287 , pp. 559-566
    • Takahashi, M.1    Jw, N.I.2    Kawasaki-Yatsugi, S.3
  • 112
    • 33845212776 scopus 로고    scopus 로고
    • Pharmacology of AMPA antagonists
    • GILL R, LODGE D: Pharmacology of AMPA antagonists. Int. Rev. Neurobiol. (1997) 40:197-232.
    • (1997) Int. Rev. Neurobiol. , vol.40 , pp. 197-232
    • Gill, R.1    Lodge, D.2
  • 113
    • 0027427281 scopus 로고
    • The effect of an AMPA antagonist (NBQX) on postischaemic neurone loss and protein synthesis in the rat brain
    • FRANK I, BRUHN T, DIEMER NH: The effect of an AMPA antagonist (NBQX) on postischaemic neurone loss and protein synthesis in the rat brain. Exp. Brain Res. (1993) 95:70-76.
    • (1993) Exp. Brain Res. , vol.95 , pp. 70-76
    • Frank, I.1    Bruhn, T.2    Diemer, N.H.3
  • 114
    • 0026623418 scopus 로고
    • Cerebroprotective effect of a non-N-methyl-D-aspartate antagonist, GYKI 52466, after focal ischemia in the rat
    • SMITH SE, MELDRUM BS: Cerebroprotective effect of a non-N-methyl-D- aspartate antagonist, GYKI 52466, after focal ischemia in the rat. Stroke (1992) 23:861-864.
    • (1992) Stroke , vol.23 , pp. 861-864
    • Smith, S.E.1    Meldrum, B.S.2
  • 115
    • 0001309070 scopus 로고    scopus 로고
    • Stroke Treatment with ancrod trial (STAT)
    • LEVAY DE: Stroke Treatment with Ancrod Trial (STAT). Stroke (1999) 30:234.
    • (1999) Stroke , vol.30 , pp. 234
    • Levay, D.E.1
  • 116
    • 0026647040 scopus 로고
    • Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia
    • CHIAMULERA C, ALBERTINI P, VALERIO E, REGGIANI A: Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia. Eur. J. Pharmacol. (1992) 216:335-336.
    • (1992) Eur. J. Pharmacol. , vol.216 , pp. 335-336
    • Chiamulera, C.1    Albertini, P.2    Valerio, E.3    Reggiani, A.4
  • 117
    • 0029052786 scopus 로고
    • The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia
    • MAGINN M, CALDWELL M, KELLY JP, LEONARD BE: The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia. Eur. J. Pharmacol. (1995) 282:259-262.
    • (1995) Eur. J. Pharmacol. , vol.282 , pp. 259-262
    • Maginn, M.1    Caldwell, M.2    Kelly, J.P.3    Leonard, B.E.4
  • 118
    • 0003038864 scopus 로고    scopus 로고
    • Preclinical studies of glutamate receptor antagonists for the treatment of cerebral ischemia
    • Miller LP (Ed.) , Wiley-Liss, New York, USA
    • SMALL DL, MORLEY P, BUCHAN AM: Preclinical studies of glutamate receptor antagonists for the treatment of cerebral ischemia. In: Stroke Therapy: Basic, Preclinical and Clinical Directions. Miller LP (Ed.), Wiley-Liss, New York, USA (1999):65-99
    • (1999) Stroke Therapy: Basic, Preclinical and Clinical Directions , pp. 65-99
    • Small, D.L.1    Morley, P.2    Buchan, A.M.3
  • 120
    • 0033951941 scopus 로고    scopus 로고
    • Selfotel in acute ischemic stroke. Possible neurotoxic effects of an NMDA antagonist
    • DAVIS SM, LEES KR, ALBERS GW et al: Selfotel in acute ischemic stroke. Possible neurotoxic effects of an NMDA antagonist. Stroke (2000) 31:347-354.
    • (2000) Stroke , vol.31 , pp. 347-354
    • Davis, S.M.1    Lees, K.R.2    Albers, G.W.3
  • 121
    • 0033388098 scopus 로고    scopus 로고
    • Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: Results of two Phase III clinical trials
    • The Selfotel Investigators
    • MORRIS GF, BULLOCK R, MARSHALL SB, MARMAROU A, MAAS A, MARSHALL LF: Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two Phase III clinical trials. The Selfotel Investigators. J. Neurosurg. (1999) 91:737-743.
    • (1999) J. Neurosurg. , vol.91 , pp. 737-743
    • Morris, G.F.1    Bullock, R.2    Marshall, S.B.3    Marmarou, A.4    Maas, A.5    Marshall, L.F.6
  • 122
    • 0030666876 scopus 로고    scopus 로고
    • Cerestat and other NMDA antagonists in ischemic stroke
    • LEES KR: Cerestat and other NMDA antagonists in ischemic stroke. Neurology (1997) 49:S66-69.
    • (1997) Neurology , vol.49
    • Lees, K.R.1
  • 123
    • 0030778895 scopus 로고    scopus 로고
    • New and investigational treatment options for ischemic stroke
    • RYAN M, RHÔNEY DH, LUER MS, HATTON J: New and investigational treatment options for ischemic stroke. Pharmacotherapy (1997) 17:959-969.
    • (1997) Pharmacotherapy , vol.17 , pp. 959-969
    • Ryan, M.1    Rhôney, D.H.2    Luer, M.S.3    Hatton, J.4
  • 124
    • 0032875690 scopus 로고    scopus 로고
    • Remacemide hydrochloride: A double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke
    • DYKER AG, LEES KR: Remacemide hydrochloride: a double-blind, placebo-controlled, safety and tolerability study in patients with acute ischemic stroke. Stroke (1999a) 30:1796-1801.
    • (1999) Stroke , vol.30 , pp. 1796-1801
    • Dyker, A.G.1    Lees, K.R.2
  • 125
    • 80052092409 scopus 로고    scopus 로고
    • IMAGES-intravenous magnesium efficacy in stroke trial IMAGES study group
    • BRADFORD AP: IMAGES-intravenous magnesium efficacy in stroke trial IMAGES study group. Stroke (2000) 31:248.
    • (2000) Stroke , vol.31 , pp. 248
    • Bradford, A.P.1
  • 126
    • 0031970836 scopus 로고    scopus 로고
    • Dose optimization of intravenous magnesium sulfate after acute stroke
    • MUIR KW, LEES KR: Dose optimization of intravenous magnesium sulfate after acute stroke. Stroke (1998) 29:918-923.
    • (1998) Stroke , vol.29 , pp. 918-923
    • Muir, K.W.1    Lees, K.R.2
  • 127
    • 0032018743 scopus 로고    scopus 로고
    • New experimental and clinical data on the efficacy of pharmacological magnesium infusions in cerebral infarcts
    • MUIR KW: New experimental and clinical data on the efficacy of pharmacological magnesium infusions in cerebral infarcts. Magnes. Res. (1998) 11:43-56.
    • (1998) Magnes. Res. , vol.11 , pp. 43-56
    • Muir, K.W.1
  • 128
    • 0007816258 scopus 로고
    • A double blind randomized pilot trial of magnesium therapy in acute cerebral infarction
    • STRAND T, WESTER PO: A double blind randomized pilot trial of magnesium therapy in acute cerebral infarction. 7 NordMeet Cerebrovasc. Dis. (1993):37.
    • (1993) NordMeet Cerebrovasc Dis , pp. 37
    • Strand, T.1    Wester, P.O.2
  • 129
    • 0012952273 scopus 로고    scopus 로고
    • Glutamate receptor antagonists for the treatment of acute cerebral ischemia
    • Goldstein LB (Eds.), Marcel Dekker, New York, USA
    • SMALL DL, MORLEY P, BUCHAN AM: Glutamate receptor antagonists for the treatment of acute cerebral ischemia. In: Management of Acute Stroke Shuaib A, Goldstein LB (Eds.), Marcel Dekker, New York, USA (1999):341-361.
    • (1999) Management of Acute Stroke Shuaib A , pp. 341-361
    • Small, D.L.1    Morley, P.2    Buchan, A.M.3
  • 130
    • 0028842314 scopus 로고
    • Potentially effective therapies for acute ischemic stroke
    • Synthelabo Reserche: Press Release Paris France (6 February 1996)
    • Synthelabo Reserche: Press Release, Paris, France (6 February 1996). FISHER M: Potentially effective therapies for acute ischemic stroke. Eur Neurol. (1995) 35:3-7.
    • (1995) Eur Neurol. , vol.35 , pp. 3-7
    • Fisher, M.1
  • 131
    • 0032914455 scopus 로고    scopus 로고
    • Antagonists selective for NMDA receptors containing the NR2B subunit
    • CHENARD BL, MENNITI FS: Antagonists selective for NMDA receptors containing the NR2B subunit. Curr Pharm. Des. (1999) 5:381-404.
    • (1999) Curr Pharm. Des. , vol.5 , pp. 381-404
    • Chenard, B.L.1    Menniti, F.S.2
  • 132
    • 0031443289 scopus 로고    scopus 로고
    • Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit Characterization in vitro
    • FISCHER G, MUTEL V, TRUBE G et al.: Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J. Pharmacol. Exp. Ther (1997) 283:1285-1292.
    • (1997) J. Pharmacol. Exp. Ther , vol.283 , pp. 1285-1292
    • Fischer, G.1    Mutel, V.2    Trube, G.3
  • 133
    • 0033392424 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury
    • MERCHANT RE, BULLOCK MR, CARMACK CA et al: A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury. Ann. NY Acad. Sci. (1999) 890:42-50.
    • (1999) Ann. NY Acad. Sci. , vol.890 , pp. 42-50
    • Merchant, R.E.1    Bullock, M.R.2    Carmack, C.A.3
  • 134
    • 0344289521 scopus 로고    scopus 로고
    • 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-meth ylbenzyl)pip. A novel, potent and selective NR1/2B NMDA receptor antagonist
    • ZHOU ZZL, CAI SX, WHITTEMORE ER et al.: 4-Hydroxy-1-[2-(4-hydroxyphenoxy) ethyl]-4-(4-meth ylbenzyl)pip. A novel, potent and selective NR1/2B NMDA receptor antagonist. J. Med. Chem. (1999) 42:2993-3000.
    • (1999) J. Med. Chem. , vol.42 , pp. 2993-3000
    • Zzl, Z.1    Cai, S.X.2    Whittemore, E.R.3
  • 135
    • 0030771671 scopus 로고    scopus 로고
    • Antinociceptive activity of CP-101, 606, an NMDA receptor NR2B subunit antagonist
    • TANIGUCHI K, SHINJO K, MIZUTANI M et al.: Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br. J. Pharmacol. (1997) 122:809-12.
    • (1997) Br. J. Pharmacol. , vol.122 , pp. 809-12
    • Taniguchi, K.1    Shinjo, K.2    Mizutani, M.3
  • 136
    • 0000278124 scopus 로고    scopus 로고
    • The effects of Cl-1041 in two tests of analgesia: Acetic acid-iduced writhing test and formalin foot pad test
    • FILLHARD JA, SERPA KA, KINSORA JJ, MELTZER LT: The effects of Cl-1041 in two tests of analgesia: acetic acid-iduced writhing test and formalin foot pad test. Soc. Neurosci. Abstr. (2000) 26:617.
    • (2000) Soc. Neurosci. Abstr. , vol.26 , pp. 617
    • Fillhard, J.A.1    Serpa, K.A.2    Kinsora, J.J.3    Meltzer, L.T.4
  • 137
    • 0032797570 scopus 로고    scopus 로고
    • Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl- tetrahydropyridine monkeys
    • BLANCHET PJ, KONITSIOTIS S, WHITTEMORE ER, ZHOU ZL, WOODWARD RM, CHASE TN: Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl- tetrahydropyridine monkeys. J. Pharmacol. Exp. Ther. (1999) 290:1034-1040.
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , pp. 1034-1040
    • Blanchet, P.J.1    Konitsiotis, S.2    Whittemore, E.R.3    Zhou, Z.L.4    Woodward, R.M.5    Chase, T.N.6
  • 138
    • 0033168012 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(arylal-kynyl)-4-benzylpiperidines
    • WRIGHT JL, GREGORY TF, BIGGE CF et al: Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylal-kynyl)-4-benzylpiperidines. J. Med. Chem. (1999) 42:2469-2477.
    • (1999) J. Med. Chem. , vol.42 , pp. 2469-2477
    • Wright, J.L.1    Gregory, T.F.2    Bigge, C.F.3
  • 139
    • 0033523611 scopus 로고    scopus 로고
    • Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1-piperidinylalkynylpyrroles,pyrazoles and imidazoles as NR1A/2B antagonists
    • WRIGHT JL, GREGORY TF, BOXER PA, MELTZER LT, SERPA KA, WISE LD: Discovery of subtype-selective NMDA receptor ligands: 4-benzyl-1- piperidinylalkynylpyrroles,pyrazoles and imidazoles as NR1A/2B antagonists. Bioorg. Med. Chem. Lett. (1999) 9:2815-2818.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 2815-2818
    • Wright, J.L.1    Gregory, T.F.2    Boxer, P.A.3    Meltzer, L.T.4    Serpa, K.A.5    Wise, L.D.6
  • 140
    • 0034026350 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: Benzimidazalone and hydantoin as phenol replacements
    • SCHELKUN RM, YUEN PW, SERPA K et al: Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements. J. Med. Chem. (2000) 43:1892-1897.
    • (2000) J. Med. Chem. , vol.43 , pp. 1892-1897
    • Schelkun, R.M.1    Yuen, P.W.2    Serpa, K.3
  • 141
    • 0034618553 scopus 로고    scopus 로고
    • Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(heteroarylalknyl)-4-benzylpiperidines
    • WRIGHT JL, GREGORY TF, KESTEN SR et al: Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(heteroarylalknyl)-4-benzylpiperidines. J. Med. Chem. (2000) 43:3408-3419.
    • (2000) J. Med. Chem. , vol.43 , pp. 3408-3419
    • Wright, J.L.1    Gregory, T.F.2    Kesten, S.R.3
  • 142
    • 0030815925 scopus 로고    scopus 로고
    • ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats
    • KRETSCHMER BD, KRATZER U, BREITHECKER K, KOCH M: ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats. Eur. J. Pharmacol. (1997) 331:109-116.
    • (1997) Eur. J. Pharmacol. , vol.331 , pp. 109-116
    • Kretschmer, B.D.1    Kratzer, U.2    Breithecker, K.3    Koch, M.4
  • 143
    • 0032967750 scopus 로고    scopus 로고
    • Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke
    • ALBERS GW, CLARK WM, ATKINSON RP, MADDEN K, DATA JL, WHITEHOUSE MJ: Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke. Stroke (1999) 30:508-513.
    • (1999) Stroke , vol.30 , pp. 508-513
    • Albers, G.W.1    Clark, W.M.2    Atkinson, R.P.3    Madden, K.4    Data, J.L.5    Whitehouse, M.J.6
  • 144
    • 80052095650 scopus 로고    scopus 로고
    • Licostinel
    • DrugsR DLicostinel. ACEA 1021. (1999) 1:27-28.
    • (1999) ACEA 1021 , vol.1 , pp. 27-28
    • Drugs, R.D.1
  • 145
    • 80052079728 scopus 로고    scopus 로고
    • Co-administration of probenecid with licostinel increases the steady state plasma level and reduces the minimum effective dose of neuroprotection in a rat model of transient focal ischemia
    • XUE D, MIYAZAKI BK, DANIELL G, CHENG X, WOODWARD RM: Co-administration of probenecid with licostinel increases the steady state plasma level and reduces the minimum effective dose of neuroprotection in a rat model of transient focal ischemia. Soc. Neurosci. Abst.(1999) 25:234.
    • (1999) Soc. Neurosci. Abst. , vol.25 , pp. 234
    • Xue, D.1    Miyazaki, B.K.2    Daniell, G.3    Cheng, X.4    Woodward, R.M.5
  • 146
    • 0032925354 scopus 로고    scopus 로고
    • Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke
    • DYKER AG, LEES KR: Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke. Stroke (1999b) 30:986-992.
    • (1999) Stroke , vol.30 , pp. 986-992
    • Dyker, A.G.1    Lees, K.R.2
  • 147
    • 0032934209 scopus 로고    scopus 로고
    • Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block
    • MEALING GA, LANTHORN TH, MURRAY CL, SMALL DL, MORLEY P: Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block. J. Pharmacol. Exp. Ther. (1999) 288:204-210.
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 204-210
    • Mealing, G.A.1    Lanthorn, T.H.2    Murray, C.L.3    Small, D.L.4    Morley, P.5
  • 148
    • 0033022769 scopus 로고    scopus 로고
    • SPD 502: A water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity
    • NIELSEN EO, VARMING T, MATHIESEN C et al: SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity. J. Pharmacol. Exp. Ther (1999) 289:1492-1501.
    • (1999) J. Pharmacol. Exp. Ther , vol.289 , pp. 1492-1501
    • Nielsen, E.O.1    Varming, T.2    Mathiesen, C.3
  • 149
    • 0030770855 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of the novel amino-3-hydroxy- 5methylisoxazole-4-propionate receptor antagonist YM90K in healthy men
    • UMEMURA K, KONDO K, IKEDA Y et al: Pharmacokinetics and safety of the novel amino-3-hydroxy-5methylisoxazole-4-propionate receptor antagonist YM90K in healthy men. J. Clin. Pharmacol. (1997) 37:719-727.
    • (1997) J. Clin. Pharmacol. , vol.37 , pp. 719-727
    • Umemura, K.1    Kondo, K.2    Ikeda, Y.3
  • 150
    • 0345691494 scopus 로고    scopus 로고
    • In vitro characterization of YM872: A selective, potent and highly water soluble AMPAreceptor antagonist
    • KOHARA A, OKADA M, OHNO K et al: In vitro characterization of YM872: a selective, potent and highly water soluble AMPAreceptor antagonist. Soc. Neurosci. Abst. (1996) 22:1528.
    • (1996) Soc. Neurosci. Abst. , vol.22 , pp. 1528
    • Kohara, A.1    Okada, M.2    Ohno, K.3
  • 153
    • 0034684750 scopus 로고    scopus 로고
    • Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[ 1,2-a]inden
    • PRATT J, JIMONET P, BOHME GA et al.: Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden. Bioorg. Med. Chem. Lett. (2000) 10:2749-2754.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 2749-2754
    • Pratt, J.1    Jimonet, P.2    Bohme, G.A.3
  • 154
    • 0034090891 scopus 로고    scopus 로고
    • AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys
    • KONITSIOTIS S, BLANCHET PJ, VERHAGEN L, LAMERS E, CHASE TN: AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys. Neurology (2000) 54:1589-1595.
    • (2000) Neurology , vol.54 , pp. 1589-1595
    • Konitsiotis, S.1    Blanchet, P.J.2    Verhagen, L.3    Lamers, E.4    Chase, T.N.5
  • 155
    • 0034327342 scopus 로고    scopus 로고
    • Novel drug development for amyotrophic lateral sclerosis
    • HURKO O, WALSH FS: Novel drug development for amyotrophic lateral sclerosis. J. Neurol. Sci. (2000) 180:21-28.
    • (2000) J. Neurol. Sci. , vol.180 , pp. 21-28
    • Hurko, O.1    Walsh, F.S.2
  • 156
    • 0020334371 scopus 로고
    • 3H]kainic acid binding sites in rat CNS as determined by autoradiography
    • MONAGHAN DT, COTMAN CW: The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography. Brain Res. (1982) 252:91-100.
    • (1982) Brain Res. , vol.252 , pp. 91-100
    • Monaghan, D.T.1    Cotman, C.W.2
  • 157
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • CONN PJ, PIN JP: Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. Toxicol. (1997) 37:205-237.
    • (1997) Ann. Rev. Pharmacol. Toxicol. , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.P.2
  • 158
    • 0030029427 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors: A new target for the therapy of neurodegenerative disorders?
    • NICOLETTI F, BRUNO V, COPANI A et al: Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders? Trends Neurosci. (1996) 19:267-271.
    • (1996) Trends Neurosci. , vol.19 , pp. 267-271
    • Nicoletti, F.1    Bruno, V.2    Copani, A.3
  • 159
    • 0029149260 scopus 로고
    • Roles of metabotropic glutamate receptors in brain plasticity and pathology
    • MILLER S, KESSLAK JP, ROMANO C, COTMAN CW: Roles of metabotropic glutamate receptors in brain plasticity and pathology. Ann. NY Acad. Sci. (1992) 757:460-474.
    • (1992) Ann. NY Acad. Sci. , vol.757 , pp. 460-474
    • Miller, S.1    Kesslak, J.P.2    Romano, C.3    Cotman, C.W.4
  • 160
    • 0029126126 scopus 로고
    • 1-Aminoindan-1,5-dicarboxylic acid: A novel antagonist at phospholipase C-linked metabotropic glutamate receptors
    • PELLICCIARI R, LUNEIA R, COSTANTINO G et al.: 1-Aminoindan-1,5- dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors.J. Med. Chem. (1995) 38:3717-3719.
    • (1995) J Med. Chem. , vol.38 , pp. 3717-3719
    • Pellicciari, R.1    Luneia, R.2    Costantino, G.3
  • 162
    • 0033556391 scopus 로고    scopus 로고
    • (1S3R)-ACPD, a metabotropic glutamate receptor agonist, enhances damage after global ischaemia
    • HENRICH-NOACK P, REYMANN KG: (1S,3R)-ACPD, a metabotropic glutamate receptor agonist, enhances damage after global ischaemia. Eur.J. Pharmacol. (1999) 365:55-58.
    • (1999) Eur. J. Pharmacol. , vol.365 , pp. 55-58
    • Henrich-Noack, P.1    Reymann, K.G.2
  • 163
    • 0032566556 scopus 로고    scopus 로고
    • Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia
    • LAM AG, SORIANO MA, MONN JA, SCHOEPP DD, LODGE D, MCCULLOCH J: Effects of the selective metabotropic glutamate agonist LY354740 in a rat model of permanent ischaemia. Neurosci. Lett. (1998) 254:121-123.
    • (1998) Neurosci. Lett. , vol.254 , pp. 121-123
    • Lam, A.G.1    Soriano, M.A.2    Monn, J.A.3    Schoepp, D.D.4    Lodge, D.5    McCulloch, J.6
  • 164
    • 0032550103 scopus 로고    scopus 로고
    • Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia
    • BOND A, O'NEILL MJ, HICKS CA, MONN JA, LODGE D: Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischaemia. Neuroreport (1998) 9:1191-1193.
    • (1998) Neuroreport , vol.9 , pp. 1191-1193
    • Bond, A.1    O'Neill, M.J.2    Hicks, C.A.3    Monn, J.A.4    Lodge, D.5
  • 166
    • 0032550097 scopus 로고    scopus 로고
    • The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils
    • HENRICH-NOACK P, HATTON CD, REYMANN KG: The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils. NeuroReport (1998) 9:985-988.
    • (1998) NeuroReport , vol.9 , pp. 985-988
    • Henrich-Noack, P.1    Hatton, C.D.2    Reymann, K.G.3
  • 167
    • 0028068803 scopus 로고
    • Changes in metabotropic glutamate receptor mRNA levels following global ischemia: Increase of a putative presynaptic subtype (mGluR4) in highly vulnerable rat brain areas
    • IVERSEN L, MULVIHILL E, HALDEMAN B et al: Changes in metabotropic glutamate receptor mRNA levels following global ischemia: increase of a putative presynaptic subtype (mGluR4) in highly vulnerable rat brain areas. J. Neurochem. (1994) 63:625-633.
    • (1994) J. Neurochem. , vol.63 , pp. 625-633
    • Iversen, L.1    Mulvihill, E.2    Haldeman, B.3
  • 168
    • 0023723433 scopus 로고    scopus 로고
    • Effect of ischemia on the in vivo release of striatal dopamine, glutamate and gamma-aminobutyric acid studied by intracerebral microdialysis
    • GLOBUS MYT, BUSTO R, DIETRICH WD et al: Effect of ischemia on the in vivo release of striatal dopamine, glutamate and gamma-aminobutyric acid studied by intracerebral microdialysis. J. Neurochem. (1998) 51:1455-1464.
    • (1998) J. Neurochem. , vol.51 , pp. 1455-1464
    • Myt, G.1    Busto, R.2    Dietrich, W.D.3
  • 169
    • 0021847574 scopus 로고
    • Ischemia-induced shift of inhibitory and excitatory amino acids from intra-and extra-cellular compartments
    • HAGBERG H, LEHMANN A, SANDBERG M et al: Ischemia-induced shift of inhibitory and excitatory amino acids from intra-and extra-cellular compartments.J. Cereb. Blood Flow Metab. (1985) 5:413-419.
    • (1985) J Cereb. Blood Flow Metab. , vol.5 , pp. 413-419
    • Hagberg, H.1    Lehmann, A.2    Sandberg, M.3
  • 170
    • 0031593981 scopus 로고    scopus 로고
    • The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes
    • HEVERS W, LUDDENS H: The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes. Mol Neurobiol (1998) 18:35-86.
    • (1998) Mol Neurobiol , vol.18 , pp. 35-86
    • Hevers, W.1    Luddens, H.2
  • 171
    • 80052079454 scopus 로고    scopus 로고
    • Gamma-aminobutyric acid agonists for neuroprotection
    • Miller LP (Ed.), Wiley-Liss, New York, USA
    • LYDEN PD: Gamma-aminobutyric acid agonists for neuroprotection. In: Stroke Therapy: Basic, Preclinical and Clinical Directions. Miller LP (Ed.), Wiley-Liss, New York, USA (1999):101-130.
    • (1999) Stroke Therapy: Basic, Preclinical and Clinical Directions , pp. 101-130
    • Lyden, P.D.1
  • 172
    • 0025913968 scopus 로고
    • Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells
    • JOHANSEN FF, DIEMER NH: Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells. Acta Neurol Scand. (1991) 84:1-6.
    • (1991) Acta Neurol Scand. , vol.84 , pp. 1-6
    • Johansen, F.F.1    Diemer, N.H.2
  • 173
    • 0024562496 scopus 로고
    • Role for gamma-aminobutyric acid in selective vulnerability in gerbils
    • STERNAU LL, LUST WD, RICCI AJ et al: Role for gamma-aminobutyric acid in selective vulnerability in gerbils. Stroke (1989) 20:281-287.
    • (1989) Stroke , vol.20 , pp. 281-287
    • Sternau, L.L.1    Lust, W.D.2    Ricci, A.J.3
  • 174
    • 0027378539 scopus 로고
    • GABAagonist 'muscimol' is neuroprotective in repetitive transient forebrain ischemia in gerbils
    • SHUAIB A, MAZAGRI R, IJAZ S: GABAagonist 'muscimol' is neuroprotective in repetitive transient forebrain ischemia in gerbils. Exp. Neurol (1993) 123:284-288.
    • (1993) Exp. Neurol , vol.123 , pp. 284-288
    • Shuaib, A.1    Mazagri, R.2    Ijaz, S.3
  • 175
    • 0015973581 scopus 로고
    • Barbiturate protection in acute focal cerebral ischemia
    • SMITH AL, HOFF JT, NIELSEN SL et al: Barbiturate protection in acute focal cerebral ischemia. Stroke (1974) 5:1-7.
    • (1974) Stroke , vol.5 , pp. 1-7
    • Smith, A.L.1    Hoff, J.T.2    Nielsen, S.L.3
  • 176
    • 0028923159 scopus 로고
    • Baclofen is cytoprotective to cerebral ischemia in gerbils
    • LAL S, SHUAIB A, IJAZ S: Baclofen is cytoprotective to cerebral ischemia in gerbils. Neurochem. Res. (1995) 20:115-119.
    • (1995) Neurochem. Res. , vol.20 , pp. 115-119
    • Lal, S.1    Shuaib, A.2    Ijaz, S.3
  • 177
    • 0011061138 scopus 로고
    • Inhibition by GABA of evoked glutamate release from cultured cerebellar granule cells
    • Hertz L, Kvamme E, McGeer EG, Schousboe A (Eds.) , Alan R Liss, New York, USA
    • MEIER E, DREJER J, SCHOUSBOE A: Inhibition by GABA of evoked glutamate release from cultured cerebellar granule cells. In: Glutamine, Glutamate and GABA in the Central Nervous System. Hertz L, Kvamme E, McGeer EG, Schousboe A (Eds.), Alan R Liss, New York, USA (1983):509-516.
    • (1983) Glutamine, Glutamate and GABA in the Central Nervous System , pp. 509-516
    • Meier, E.1    Drejer, J.2    Schousboe, A.3
  • 178
    • 0025924761 scopus 로고
    • GABA-B receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus
    • MORRISETT RA, MOTT DD, LEWIS DV et al: GABA-B receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. J. Neurosci. (1991) 11:203-209.
    • (1991) J. Neurosci. , vol.11 , pp. 203-209
    • Morrisett, R.A.1    Mott, D.D.2    Lewis, D.V.3
  • 179
    • 0020327615 scopus 로고
    • The blocking action of baclofen on excitatory transmission in the rat hippocampal slice
    • OLPE H-R, BAUDRY M, FAGNI L et al: The blocking action of baclofen on excitatory transmission in the rat hippocampal slice. J. Neurosci. (1982) 2:698-703.
    • (1982) J. Neurosci. , vol.2 , pp. 698-703
    • Olpe, H.-R.1    Baudry, M.2    Fagni, L.3
  • 180
    • 0034078117 scopus 로고    scopus 로고
    • GABA potentiation: A logical pharmacological approach for the treatment of acute ischaemic stroke
    • GREEN AR, HAINSWORTH AH, JACKSON DM: GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke. Neurophar-macol. (2000) 39:1483-1494.
    • (2000) Neurophar-macol. , vol.39 , pp. 1483-1494
    • Green, A.R.1    Hainsworth, A.H.2    Jackson, D.M.3
  • 181
    • 0027526541 scopus 로고
    • The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat
    • SNAPE MF, BALDWIN HA, CROSS AJ et al: The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat. Neurosci-ence (1993) 53:837-844.
    • (1993) Neurosci-ence , vol.53 , pp. 837-844
    • Snape, M.F.1    Baldwin, H.A.2    Cross, A.J.3
  • 182
    • 0029101630 scopus 로고
    • Chlomethiazole protects the brain in transient forebrain ischemia when used up to 4 h after the insult
    • SHUIAB A, IJAZS, KANTHAN R: Chlomethiazole protects the brain in transient forebrain ischemia when used up to 4 h after the insult. Neurosci. Lett. (1995) 197:109-112.
    • (1995) Neurosci. Lett. , vol.197 , pp. 109-112
    • Shuiab, A.1    Ijazs Kanthan, R.2
  • 183
    • 0026094214 scopus 로고
    • Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil
    • CROSS AJ, JONES JA, BALDWIN HA et al: Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil. Br. J. Pharmacol (1991) 104:406-411.
    • (1991) Br. J. Pharmacol , vol.104 , pp. 406-411
    • Cross, A.J.1    Jones, J.A.2    Baldwin, H.A.3
  • 184
    • 0032953495 scopus 로고    scopus 로고
    • Chlomethiazole Acute Stroke Study (CLASS): Results of a randomised controlled trial of chlomethiazole versus placebo in 1360 acute stroke patients
    • WAHLGREN NG, RANASINHA KW, ROSOLACCI T et al: Chlomethiazole Acute Stroke Study (CLASS): results of a randomised controlled trial of chlomethiazole versus placebo in 1360 acute stroke patients. Stroke (1999a) 30:21-28.
    • (1999) Stroke , vol.30 , pp. 21-28
    • Wahlgren, N.G.1    Ranasinha, K.W.2    Rosolacci, T.3
  • 185
    • 0000251781 scopus 로고    scopus 로고
    • The Chlomethiazole Acute Stroke Study (CLASS): Efficacy results in 545 patients classified as total anterior circulation syndrome (TACS)
    • WAHLGREN NG, BORNHOV S, SHARMA A et al: The Chlomethiazole Acute Stroke Study (CLASS): efficacy results in 545 patients classified as total anterior circulation syndrome (TACS). J. Stroke Cerebravasc. Dis. (1999b) 8:1-10.
    • (1999) J. Stroke Cerebravasc. Dis. , vol.8 , pp. 1-10
    • Wahlgren, N.G.1    Bornhov, S.2    Sharma, A.3
  • 186
    • 0034643745 scopus 로고    scopus 로고
    • Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy
    • ASPECTS Study Group. Alberta Stroke Programme Early CT Score
    • BARBER PA, DEMCHUK AM, ZHANG J, BUCHAN AM: Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group. Alberta Stroke Programme Early CT Score. Lancet (2000) 355:1670-1674.
    • (2000) Lancet , vol.355 , pp. 1670-1674
    • Barber, P.A.1    Demchuk, A.M.2    Zhang, J.3    Buchan, A.M.4
  • 187
    • 0033950815 scopus 로고    scopus 로고
    • KEIGHLEYJ: Defining post-stroke recovery: Implications for design and interpretation of drug trials
    • DUNCAN PW, LAI SM, KEIGHLEYJ: Defining post-stroke recovery: implications for design and interpretation of drug trials. Neuropharmacology (2000) 39:835-841.
    • (2000) Neuropharmacology , vol.39 , pp. 835-841
    • Duncan, P.W.1    Lai, S.M.2
  • 188
    • 0025925116 scopus 로고
    • 2+ influx during anoxia in mammalian central nervous system white matter
    • STYS PK, WAXMAN SG, RANSOM BR: Na+-Ca2+exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Ann. Neurol (1991) 30:375-380.
    • (1991) Ann. Neurol , vol.30 , pp. 375-380
    • Stys, P.K.1    Waxman, S.G.2    Ransom, B.R.3
  • 189
    • 0026556810 scopus 로고
    • 2+ exchanger
    • STYS PK, WAXMAN SG, RANSOM BR: Ionic mechanism of anoxic injury in mammalian CNS white matter: Role of Na+ channels and Na+-Ca2+ exchanger. J. Neurosci. (1992) 12:430-439.
    • (1992) J. Neurosci. , vol.12 , pp. 430-439
    • Stys, P.K.1    Waxman, S.G.2    Ransom, B.R.3
  • 190
    • 0028340051 scopus 로고
    • Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischaemia
    • XIE Y, DENGLER K, ZACHARIAS E et al: Effects of the sodium channel blocker tetrodotoxin (TTX) on cellular ion homeostasis in rat brain subjected to complete ischaemia. Brain Res. (1994) 652:216-224.
    • (1994) Brain Res. , vol.652 , pp. 216-224
    • Xie, Y.1    Dengler, K.2    Zacharias, E.3
  • 191
    • 0024853138 scopus 로고
    • The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice
    • BOENING JA, KASS IS, COTTRELL JE et al: The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice. Neuroscience (1989) 33:263-268.
    • (1989) Neuroscience , vol.33 , pp. 263-268
    • Boening, J.A.1    Kass, I.S.2    Cottrell, J.E.3
  • 192
    • 0026599820 scopus 로고
    • Tertiery and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability
    • STYS PK, RANSOM BR, WAXMAN SG: Tertiery and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability. J. Neurophysiol (1992) 67:236-240.
    • (1992) J. Neurophysiol , vol.67 , pp. 236-240
    • Stys, P.K.1    Ransom, B.R.2    Waxman, S.G.3
  • 193
    • 0028959228 scopus 로고
    • Cerebroprotective effect of lamotrigine after focal ischaemia in rats
    • SMITH SE, MELDRUM BS: Cerebroprotective effect of lamotrigine after focal ischaemia in rats. Stroke (1995) 26:117-122.
    • (1995) Stroke , vol.26 , pp. 117-122
    • Smith, S.E.1    Meldrum, B.S.2
  • 194
    • 0028362182 scopus 로고
    • Neuroprotective effects of a use-dependent blocker of voltage dependent sodium channel, BW619C89, in rat middle cerebral artery occlusion
    • GRAHAM SH, CHEN J, LAN J et al.: Neuroprotective effects of a use-dependent blocker of voltage dependent sodium channel, BW619C89, in rat middle cerebral artery occlusion.J. Pharmacol Exp. Ther. (1994) 269:854-859.
    • (1994) J Pharmacol Exp. Ther. , vol.269 , pp. 854-859
    • Graham, S.H.1    Chen, J.2    Lan, J.3
  • 195
    • 0027287896 scopus 로고
    • BW619C89, a glutamate release inhibitor, protects against focal cerebral ischaemic damage
    • LEACH MJ, SWAN JH, EISENTHAL D et al: BW619C89, a glutamate release inhibitor, protects against focal cerebral ischaemic damage. Stroke (1993) 24:1063-1067.
    • (1993) Stroke , vol.24 , pp. 1063-1067
    • Leach, M.J.1    Swan, J.H.2    Eisenthal, D.3
  • 196
    • 0028939058 scopus 로고
    • Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia
    • WIARD RP, DICKERSON MC, BEEK O et al: Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke (1995) 26:466-472.
    • (1995) Stroke , vol.26 , pp. 466-472
    • Wiard, R.P.1    Dickerson, M.C.2    Beek, O.3
  • 197
    • 0028172871 scopus 로고
    • Hypoxic-ischaemic injury in the neonatal rat brain: Effects of pre-and post-treatment with the glutamate release inhibitor BW1003C87
    • GILLAND E, MALGORZATA P-S, ANDINE P et al.: Hypoxic-ischaemic injury in the neonatal rat brain: effects of pre-and post-treatment with the glutamate release inhibitor BW1003C87. Dev. Brain Res. (1994) 83:79-84.
    • (1994) Dev. Brain Res. , vol.83 , pp. 79-84
    • Gilland, E.1    Malgorzata, P.-S.2    Andine, P.3
  • 198
    • 0027208558 scopus 로고
    • The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons followingtransient severe forebrain ischaemia in rats. A microdialysis and histological study
    • LEKIEFFRE D, MELDRUM BS: The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons followingtransient severe forebrain ischaemia in rats. A microdialysis and histological study. Neuroscience (1993) 56:93-99.
    • (1993) Neuroscience , vol.56 , pp. 93-99
    • Lekieffre, D.1    Meldrum, B.S.2
  • 199
    • 0026767197 scopus 로고
    • Neuroprotective actions of riluzole in rodent models of global and focal ischaemia
    • PRATT J, RATAUD J, BARDOT F et al: Neuroprotective actions of riluzole in rodent models of global and focal ischaemia. Neurosci. Lett. (1992) 140:225-230.
    • (1992) Neurosci. Lett. , vol.140 , pp. 225-230
    • Pratt, J.1    Rataud, J.2    Bardot, F.3
  • 200
    • 0027469132 scopus 로고
    • Effect of riluzole on focal cerebral ischaemia in rats
    • WAHL F, ALLIX M, PLOTKINE M et al: Effect of riluzole on focal cerebral ischaemia in rats. Eur J. Pharmacol (1993) 230:209-214.
    • (1993) Eur J. Pharmacol , vol.230 , pp. 209-214
    • Wahl, F.1    Allix, M.2    Plotkine, M.3
  • 201
    • 7244254000 scopus 로고
    • Pharmacological profile and neuroprotective activities of RP 66055, a riluzole derivative, in rodents
    • STRUZMANN JM, MIGNANI S, DEBARNOT F et al.: Pharmacological profile and neuroprotective activities of RP 66055, a riluzole derivative, in rodents. Soc. Neurosci. Abstr. (1993) 19:1647.
    • (1993) Soc. Neurosci. Abstr. , vol.19 , pp. 1647
    • Struzmann, J.M.1    Mignani, S.2    Debarnot, F.3
  • 202
    • 0024307317 scopus 로고
    • Riluzole, a novel anti-glutamate prevents memory loss and hippocampal neuronal damage in ischaemic gerbils
    • MALGOURIS C, BARDOT F, DANIEL M et al: Riluzole, a novel anti-glutamate prevents memory loss and hippocampal neuronal damage in ischaemic gerbils.J. Neurosci. (1989) 9:3720-3727.
    • (1989) J Neurosci. , vol.9 , pp. 3720-3727
    • Malgouris, C.1    Bardot, F.2    Daniel, M.3
  • 203
    • 0029753270 scopus 로고    scopus 로고
    • The pharmacology and mechanism of action of riluzole
    • DOBLE A: The pharmacology and mechanism of action of riluzole. Neurology (1996) 47:S233-S241.
    • (1996) Neurology , vol.47
    • Doble, A.1
  • 204
    • 0002916674 scopus 로고
    • Pharmacology and mechanism of action of lamotrigine
    • (Reynolds EH Ed), Royal Society of Medicine Services Ltd., London, UK
    • MELDRUM BS: Pharmacology and mechanism of action of lamotrigine. In Lamotrigine-A New Advance in the Treatment of Epilepsy (Reynolds EH Ed), Royal Society of Medicine Services Ltd., London, UK (1993):5-14.
    • (1993) Lamotrigine-A New Advance in the Treatment of Epilepsy , pp. 5-14
    • Meldrum, B.S.1
  • 205
    • 0026923947 scopus 로고
    • IUPHAR classification of calcium channels and drugs modifying channel function
    • SPEDDING M, PAOLETTI R: IUPHAR classification of calcium channels and drugs modifying channel function. Pharmacol Rev. (1992) 44:363-376.
    • (1992) Pharmacol Rev. , vol.44 , pp. 363-376
    • Spedding, M.1    Paoletti, R.2
  • 206
    • 0025355645 scopus 로고
    • Calcium channels in vertebrate cells
    • HESS P: Calcium channels in vertebrate cells. Ann. Rev. Neurosci. (1990) 13:337-356.
    • (1990) Ann. Rev. Neurosci. , vol.13 , pp. 337-356
    • Hess, P.1
  • 207
    • 0026610268 scopus 로고
    • 2+channels
    • MILLER RJ: Voltage-sensitive Ca2+ channels. J. Biol Chem. (1992) 267:1403-1406.
    • (1992) J. Biol Chem. , vol.267 , pp. 1403-1406
    • Miller, R.J.1
  • 208
    • 0343629678 scopus 로고
    • Calcium channels: Introduction to their molecular pharmacology
    • Fleckenstein A, Van Bremen C, Grob R, Hoffmeister F (Eds.) , Springer-Verlag, Berlin, Germany
    • GLOSSMAN H, FERRY DR, GOLL A et al: Calcium channels: introduction to their molecular pharmacology. In: Cardiovascular Effects of Dihydropyridine-type Calcium Antagonists and Agonists. Fleckenstein A, Van Bremen C, Grob R, Hoffmeister F (Eds.), Springer-Verlag, Berlin, Germany (1985):113-139.
    • (1985) Cardiovascular Effects of Dihydropyridine-type Calcium Antagonists and Agonists , pp. 113-139
    • Glossman, H.1    Ferry, D.R.2    Goll, A.3
  • 209
    • 0032513989 scopus 로고    scopus 로고
    • Cloningand characteri zation of alpha1Hfrom human heart, a member of the T-type Ca2+ channel gene family
    • CRIBBS LL, LEEJH, YANG J et al: Cloningand characteri zation of alpha1Hfrom human heart, a member of the T-type Ca2+ channel gene family. Circ. Res. (1998) 83:103-109.
    • (1998) Circ. Res. , vol.83 , pp. 103-109
    • Cribbs, L.L.1    Lee, J.H.2    Yang, J.3
  • 210
    • 0032568011 scopus 로고    scopus 로고
    • Molecular characterization of a neuronal low-voltage-activated T-type calcium channel
    • PEREZ-REYES E, CRIBBS LL, DAUD A et al.: Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature (1998) 391:896-900.
    • (1998) Nature , vol.391 , pp. 896-900
    • Perez-Reyes, E.1    Cribbs, L.L.2    Daud, A.3
  • 211
    • 0026448583 scopus 로고
    • Calcium channels coupled to glutamate release identified by omega-Aga-IVA
    • TURNER TJ, ADAMS ME, DUNLAP K: Calcium channels coupled to glutamate release identified by omega-Aga-IVA. Science (1992) 258:310-313.
    • (1992) Science , vol.258 , pp. 310-313
    • Turner, T.J.1    Adams, M.E.2    Dunlap, K.3
  • 212
    • 0025938297 scopus 로고
    • L-type voltage-sensitive calcium channels mediate synaptic activa-tionofimmediateearly genes
    • MURPHY TH, WORLEY PF, BARABAN JM: L-type voltage-sensitive calcium channels mediate synaptic activa-tionofimmediateearly genes. Neuron (1991) 7:625-635.
    • (1991) Neuron , vol.7 , pp. 625-635
    • Murphy, T.H.1    Worley, P.F.2    Baraban, J.M.3
  • 213
    • 0025131776 scopus 로고
    • 2+channels at the base of major dendrites in hippocampal pyramidal neurons
    • WESTENBROEK RE, AHLIJANIAN MK, CATTERALL WA: Clustering of L-type Ca2+ channels at the base of major dendrites in hippocampal pyramidal neurons. Nature (1990) 347:281-284.
    • (1990) Nature , vol.347 , pp. 281-284
    • Westenbroek, R.E.1    Ahlijanian, M.K.2    Catterall, W.A.3
  • 214
    • 0029114376 scopus 로고
    • Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia
    • BROWN CM, CALDER C, LINTON Cet al.: Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia. Br. J. Pharmacol. (1995) 115:1425-1432.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1425-1432
    • Brown, C.M.1    Calder, C.2    Linton, C.3
  • 215
    • 0025647303 scopus 로고    scopus 로고
    • Effects of nimodipine on infarct size and cerebral acidosis after middle cerebral artery in the rat
    • BIELENBERG GW, BURNIOL M, ROSEN R et al.: Effects of nimodipine on infarct size and cerebral acidosis after middle cerebral artery in the rat. Stroke 21:IV90-IV92.
    • Stroke , vol.21
    • Bielenberg, G.W.1    Burniol, M.2    Rosen, R.3
  • 216
    • 0025579251 scopus 로고
    • Nimodipine attenuates both ischaemia-induced brain oedema and mortality in a rat novel transient middle cerebral artery occlusion model
    • HARAH, NAGASAWAH, KOGUREK: Nimodipine attenuates both ischaemia-induced brain oedema and mortality in a rat novel transient middle cerebral artery occlusion model. Acta Neurochirur. (1990) 51:251-253.
    • (1990) Acta Neurochirur. , vol.51 , pp. 251-253
    • Hara, H.1    Nagasawa, H.2    Kogure, K.3
  • 217
    • 0023905674 scopus 로고    scopus 로고
    • Comparative protective effects of nicardipine, flunarizine, lidocaine and nimodipine against ischaemic injury in the hippocampusofthe Mongolian gerbil
    • ALPS BJ, CALDER C, HASS WK et al.: Comparative protective effects of nicardipine, flunarizine, lidocaine and nimodipine against ischaemic injury in the hippocampusofthe Mongolian gerbil. Br. J. Pharmacol. (1998) 93:877-883.
    • (1998) Br. J. Pharmacol. , vol.93 , pp. 877-883
    • Alps, B.J.1    Calder, C.2    Hass, W.K.3
  • 218
    • 0028886705 scopus 로고
    • Failure of isradipine to reduce infarct size in mouse, gerbil and rat models of cerebral ischaemia
    • BAILEY SJ, WOOD NI, SAMSON NA et al.: Failure of isradipine to reduce infarct size in mouse, gerbil and rat models of cerebral ischaemia. Stroke (1995) 26:2177-2183.
    • (1995) Stroke , vol.26 , pp. 2177-2183
    • Bailey, S.J.1    Wood, N.I.2    Samson, N.A.3
  • 219
    • 0027330305 scopus 로고
    • 2+ antagonist fails to reduce infarct size following rat middle-cerebral artery occlusion
    • KAWAMURA S, YAUI N, SHIRASAWA M et al.: Att-877, a Ca2+ antagonist fails to reduce infarct size following rat middle-cerebral artery occlusion. Acta Neurol. Scand. (1993) 88:269-272.
    • (1993) Acta Neurol. Scand. , vol.88 , pp. 269-272
    • Kawamura, S.1    Yaui, N.2    Shirasawa, M.3
  • 220
    • 0029160071 scopus 로고
    • SB201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischaemia in rats and mice
    • BARONE FC, LYSKO PG, PRICE WJ et al.: SB201823-A antagonizes calcium currents in central neurons and reduces the effects of focal ischaemia in rats and mice. Stroke (1995) 26:1683-1690.
    • (1995) Stroke , vol.26 , pp. 1683-1690
    • Barone, F.C.1    Lysko, P.G.2    Price, W.J.3
  • 221
    • 0028328642 scopus 로고
    • Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischaemia
    • BARONE FC, PRICE WJ, JAKOBSEN P et al.: Pharmacological profile of a novel neuronal calcium channel blocker includes reduced cerebral damage and neurological deficits in rat focal ischaemia. Pharmacol. Biochem. Behav. (1994) 48:177-185.
    • (1994) Pharmacol. Biochem. Behav. , vol.48 , pp. 177-185
    • Barone, F.C.1    Price, W.J.2    Jakobsen, P.3
  • 222
    • 0027426436 scopus 로고
    • 2+ antagonist is neuropro-tective in two models of cerebral ischaemia
    • BENHAM CD, BROWN TH, COOPER DG et al.: SB210823-A, a neuronal Ca2+ antagonist is neuropro-tective in two models of cerebral ischaemia. Neuropharmacology (1993) 32:1249-1257.
    • (1993) Neuropharmacology , vol.32 , pp. 1249-1257
    • Benham, C.D.1    Brown, T.H.2    Cooper, D.G.3
  • 223
    • 26144458732 scopus 로고
    • The effects of SB 206284A, a novel calcium channel antagonist, in two species in a focal model of cerebral ischaemia
    • WOOD NI, BENHAM CD, BROWN TH et al.: The effects of SB 206284A, a novel calcium channel antagonist, in two species in a focal model of cerebral ischaemia. J. Cereb. Blood Flow Metab. (1995) 15:S384.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15
    • Wood, N.I.1    Benham, C.D.2    Brown, T.H.3
  • 224
    • 0000282067 scopus 로고    scopus 로고
    • Calcium channel antagonists: Their role in neuroprotection
    • Green AR, Cross AJ (Eds.), Academic Press, San Diego, CA, USA
    • HUNTER AJ: Calcium channel antagonists: their role in neuroprotection. In: Neuroprotective Agents and Cerebral Ischaemia. Green AR, Cross AJ (Eds.), Academic Press, San Diego, CA, USA (1997):95-108.
    • (1997) Neuroprotective Agents and Cerebral Ischaemia , pp. 95-108
    • Hunter, A.J.1
  • 225
    • 0025055194 scopus 로고
    • Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischaemia
    • JACEWICZ M, BRINT S, TANABE J et al.: Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischaemia. J. Cereb. Blood Flow Metab. (1990) 10:89-96.
    • (1990) J. Cereb. Blood Flow Metab. , vol.10 , pp. 89-96
    • Jacewicz, M.1    Brint, S.2    Tanabe, J.3
  • 226
    • 0025605628 scopus 로고
    • Nimodipine binding in focal cerebral ischaemia
    • HOGAN M, GJEDDE A, HAKIM AM: Nimodipine binding in focal cerebral ischaemia. Stroke (1990) 21:78-80.
    • (1990) Stroke , vol.21 , pp. 78-80
    • Hogan, M.1    Gjedde, A.2    Hakim, A.M.3
  • 227
    • 0023855123 scopus 로고
    • L-type calcium channels are modified in rat hippocampus by short-term experimental ischaemia
    • MAGNONI MS, GOTONI S, BATTAINI F et al.: L-type calcium channels are modified in rat hippocampus by short-term experimental ischaemia. J. Cereb. Blood Flow Metab. (1988) 8:96-99.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 96-99
    • Magnoni, M.S.1    Gotoni, S.2    Battaini, F.3
  • 228
    • 84939677173 scopus 로고
    • Meta-analysis of oral nimodipine trials in acute ischemic stroke
    • MOHR JP, ORGOGOZO JM, HARRISON MJG et al.: Meta-analysis of oral nimodipine trials in acute ischemic stroke. Cerebrovasc. Dis. (1994) 4:197-203.
    • (1994) Cerebrovasc. Dis. , vol.4 , pp. 197-203
    • Mohr, J.P.1    Orgogozo, J.M.2    Mjg, H.3
  • 229
    • 0028243698 scopus 로고
    • Arandomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke
    • KASTE M, FOGELHOLM R, ERILA T et al.: Arandomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke. Stroke (1994) 25:1348-1353.
    • (1994) Stroke , vol.25 , pp. 1348-1353
    • Kaste, M.1    Fogelholm, R.2    Erila, T.3
  • 230
    • 0002549029 scopus 로고    scopus 로고
    • Very early nimodipine use in stroke (VENUS)
    • HORN J, LIMBURG M, VERMEULEN M: Very early nimodipine use in stroke (VENUS). Stroke (1999) 30:243.
    • (1999) Stroke , vol.30 , pp. 243
    • Horn, J.1    Limburg, M.2    Vermeulen, M.3
  • 231
    • 0028171089 scopus 로고
    • 2+ channel blocker prevents CA1 injury 24h following severe forebrain ischaemia and reduces infarction following focal ischaemia
    • BUCHAN AM, GERTLER SZ, LI H et al.: A selective N-type Ca2+ channel blocker prevents CA1 injury 24h following severe forebrain ischaemia and reduces infarction following focal ischaemia. J. Cereb. Blood Flow Metab. (1994) 14:903-910.
    • (1994) J. Cereb. Blood Flow Metab. , vol.14 , pp. 903-910
    • Buchan, A.M.1    Gertler, S.Z.2    I, H.L.3
  • 232
    • 0029071679 scopus 로고
    • Aselective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischaemia
    • TAKIZAWA S, MATSUSHIMA K, FUJITA F et al.: Aselective N-type calcium channel antagonist reduces extracellular glutamate release and infarct volume in focal cerebral ischaemia. J. Cereb. Blood Flow Metab. (1995) 15:611-618.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 611-618
    • Takizawa, S.1    Matsushima, K.2    Fujita, F.3
  • 233
    • 0028167832 scopus 로고
    • The omega-conopeptide SNX-111, an N-type calcium channel blocker, dramatically ameliorates brain damage due to transient focal ischaemia
    • ZHAO Q, SMITH ML, SIESJO BK: The omega-conopeptide SNX-111, an N-type calcium channel blocker, dramatically ameliorates brain damage due to transient focal ischaemia. Acta Physiol. Scand. (1994) 150:459-461.
    • (1994) Acta Physiol. Scand. , vol.150 , pp. 459-461
    • Zhao, Q.1    Smith, M.L.2    Siesjo, B.K.3
  • 234
    • 0027268233 scopus 로고
    • A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischaemia
    • VALENTINO K, NEWCOMB R, GADBOIS T et al.: A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischaemia. Neurobiology (1993) 90:7894-7897.
    • (1993) Neurobiology , vol.90 , pp. 7894-7897
    • Valentino, K.1    Newcomb, R.2    Gadbois, T.3
  • 235
    • 0028174640 scopus 로고
    • Omega-Conotoxin GVIA protects against ischemia-induced neuronal death in the mongolian gerbil but not against quinolinic acid-induced neurotoxicity in the rat
    • YAMADA K, TERAOKA T, MORITA S et al.: Omega-Conotoxin GVIA protects against ischemia-induced neuronal death in the mongolian gerbil but not against quinolinic acid-induced neurotoxicity in the rat. Neuropharmacology (1994) 33:251-254.
    • (1994) Neuropharmacology , vol.33 , pp. 251-254
    • Yamada, K.1    Teraoka, T.2    Morita, S.3
  • 236
    • 80052092245 scopus 로고    scopus 로고
    • Sodium and calcium channel modulators in stroke therapy
    • LP Miller (Ed.), Wiley-Liss, Inc
    • SPEDDING M: Sodium and calcium channel modulators in stroke therapy In: Stroke Therapy: Basic, Preclinical and Clinical Directions. LP Miller (Ed.), Wiley-Liss, Inc. (1999):157-193.
    • (1999) Stroke Therapy: Basic, Preclinical and Clinical Directions , pp. 157-193
    • Spedding, M.1
  • 238
    • 0031052321 scopus 로고    scopus 로고
    • Explora tion of P-type Ca2+ channels as drug targets for the treatment of epilepsy or ischemic stroke
    • LINGENHOHL K, SMALL DL, MONETTE R et al.: Explora tion of P-type Ca2+ channels as drug targets for the treatment of epilepsy or ischemic stroke. Neurophar macology (1997) 36:107-13.
    • (1997) Neurophar Macology , vol.36 , pp. 107-13
    • Lingenhohl, K.1    Small, D.L.2    Monette, R.3
  • 239
    • 0034615882 scopus 로고    scopus 로고
    • Omega-agatoxin IVA-sensitive Ca( 2+) channel blocker, alpha-eudesmol, protects against brain injury after focal ischemia in rats
    • ASAKURA K, MATSUO Y, OSHIMA T et al.: Omega-agatoxin IVA-sensitive Ca(2+) channel blocker, alpha-eudesmol, protects against brain injury after focal ischemia in rats. Eur. J. Pharmacol. (2000) 394:57-65.
    • (2000) Eur. J. Pharmacol. , vol.394 , pp. 57-65
    • Asakura, K.1    Matsuo, Y.2    Oshima, T.3
  • 240
    • 0034604785 scopus 로고    scopus 로고
    • Effects of blockade of voltage-sensitive Ca(2+)/Na(+) channels by a novel phenylpyrimidine derivative, NS-7, on CREB phosphorylation in focal cerebral ischemia in the rat
    • TANAKA K, NOGAWA S, NAGATA E et al: Effects of blockade of voltage-sensitive Ca(2+)/Na(+) channels by a novel phenylpyrimidine derivative, NS-7, on CREB phosphorylation in focal cerebral ischemia in the rat. Brain Res. (2000) 873:83-93.
    • (2000) Brain Res. , vol.873 , pp. 83-93
    • Tanaka, K.1    Nogawa, S.2    Nagata, E.3
  • 241
    • 0034637278 scopus 로고    scopus 로고
    • Charac terisation of SB-221420-A-a neuronal Ca(2+) andNa(+) channel antagonist in experimental models of stroke
    • CAMPBELL CA, BARONE FC, BENHAM CD et al: Charac terisation of SB-221420-A-a neuronal Ca(2+) andNa(+) channel antagonist in experimental models of stroke. Eur J. Pharmacol (2000) 401:419-428.
    • (2000) Eur J. Pharmacol , vol.401 , pp. 419-428
    • Campbell, C.A.1    Barone, F.C.2    Benham, C.D.3
  • 242
    • 0033819571 scopus 로고    scopus 로고
    • Is there a role for potassium channel openers in neuronal ion channel disorders?
    • LAWSON K: Is there a role for potassium channel openers in neuronal ion channel disorders? Exp. Opin. Invest. Drugs (2000) 9:2269-2280.
    • (2000) Exp. Opin. Invest. Drugs , vol.9 , pp. 2269-2280
    • Lawson, K.1
  • 244
    • 0026777223 scopus 로고
    • Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology
    • SIESJO BK: Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J. Neurosurg. (1992) 77:169-184.
    • (1992) J. Neurosurg. , vol.77 , pp. 169-184
    • Siesjo, B.K.1
  • 245
    • 0029006439 scopus 로고
    • + channel blocking agents
    • ZETTERSTROM TSC, VAUGHAN-JONES RD, GRAHAME-SMITH DG: Ashort period of hypoxia produces a rapid and transient rise in [K+]e in rat hippocampus in vivo which is inhibited by certain K+ channel blocking agents. Neuroscience (1995) 67:815-821.
    • (1995) Neuroscience , vol.67 , pp. 815-821
    • Tsc, Z.1    Vaughan-Jones, R.D.2    Grahame-Smith, D.G.3
  • 246
    • 0025310006 scopus 로고
    • Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurons
    • DUCHEN MR: Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurons. J. Physiol (1990) 424:387-409.
    • (1990) J. Physiol , vol.424 , pp. 387-409
    • Duchen, M.R.1
  • 247
    • 0024319441 scopus 로고
    • + channel, on anoxic response of hippocampal neurons
    • BEN-ARIY: Effects of glebenclamide, a selective blocker of ATP-K+ channel, on anoxic response of hippocampal neurons. Pflugers Arch. (1989) 414:111-114.
    • (1989) Pflugers Arch. , vol.414 , pp. 111-114
    • Ben-Ariy1
  • 248
    • 0025035914 scopus 로고
    • + channels reduce anoxic depolarization in CA3 hippocampal neurons
    • BEN-ARI Y, KRNJEVIC K, CREPEL V: Activators of ATP-sensitive K+channels reduce anoxic depolarization in CA3 hippocampal neurons. Neuroscience (1990) 37:55-60.
    • (1990) Neuroscience , vol.37 , pp. 55-60
    • Ben-Ari, Y.1    Krnjevic, K.2    Crepel, V.3
  • 249
    • 0029058583 scopus 로고
    • Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain
    • XIE Y, ZACHARIAS E, HOFF P et al: Ion channel involvement in anoxic depolarization induced by cardiac arrest in rat brain. J. Cereb. Blood Flow Metab. (1995) 15:587-594.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 587-594
    • Xie, Y.1    Zacharias, E.2    Hoff, P.3
  • 250
    • 0000521423 scopus 로고    scopus 로고
    • Mediation of neuronal apoptosis by enhancement of outward potassium current
    • YU SP, YEH CH, SENSI SL et al: Mediation of neuronal apoptosis by enhancement of outward potassium current. Science. (1997) 278:114-117.
    • (1997) Science. , vol.278 , pp. 114-117
    • Sp, Y.U.1    Yeh, C.H.2    Sensi, S.L.3
  • 251
    • 0010155285 scopus 로고    scopus 로고
    • Role of the outward delayed rectifier K+currentin ceramide-induced caspase activation and apoptosis in cultured cortical neurons
    • YU SP, YEH CH, GOTTRON F, WANG X, GRABB MC, CHOI DW: Role of the outward delayed rectifier K+currentin ceramide-induced caspase activation and apoptosis in cultured cortical neurons. J. Neurochem. (1999) 73:933-941.
    • (1999) J. Neurochem. , vol.73 , pp. 933-941
    • Sp, Y.U.1    Yeh, C.H.2    Gottron, F.3    Wang, X.4    Grabb, M.C.5    Choi, D.W.6
  • 252
    • 0032834460 scopus 로고    scopus 로고
    • A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis
    • MONTAGUE JW, BORTNER CD, HUGHES FM JR, CIDLOWSKI JA: A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis. Steroids (1999) 64:563-569.
    • (1999) Steroids , vol.64 , pp. 563-569
    • Montague, J.W.1    Bortner, C.D.2    Hughes Jr., F.M.3    Cidlowski, J.A.4
  • 253
    • 0345240928 scopus 로고    scopus 로고
    • Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo
    • HUGHES FM JR, CIDLOWSKI JA: Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Adv. Enzyme Regul. (1999) 39:157-171.
    • (1999) Adv. Enzyme Regul. , vol.39 , pp. 157-171
    • Hughes Jr., F.M.1    Cidlowski, J.A.2
  • 254
    • 0033618445 scopus 로고    scopus 로고
    • Caspase independent/dependent regulation of K(+), cell shrinkage and mitochondrial membrane potential during lymphocyte apoptosis
    • BORTNER CD, CIDLOWSKI JA: Caspase independent/dependent regulation of K(+), cell shrinkage and mitochondrial membrane potential during lymphocyte apoptosis. J. Biol. Chem. (1999) 274:21953-21962.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21953-21962
    • Bortner, C.D.1    Cidlowski, J.A.2
  • 255
    • 0031773579 scopus 로고    scopus 로고
    • A necessary role for cell shrinkage in apoptosis
    • BORTNER CD, CIDLOWSKI JA: A necessary role for cell shrinkage in apoptosis. Biochem. Pharmacol. (1998) 56:1549-1559.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 1549-1559
    • Bortner, C.D.1    Cidlowski, J.A.2
  • 256
    • 0031451872 scopus 로고    scopus 로고
    • Aprimary role for K+ and Na+ efflux in the activation of apoptosis
    • BORTNER CD, HUGHES FMJR, CIDLOWSKI JA:Aprimary role for K+ and Na+ efflux in the activation of apoptosis. J. Biol. Chem. (1997) 272:32436-32442.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32436-32442
    • Bortner, C.D.1    Hughes Jr., F.M.2    Cidlowski, J.A.3
  • 257
    • 15644374609 scopus 로고    scopus 로고
    • Intracellular K+ suppresses the activation of apoptosis in lymphocytes
    • HUGHES FM JR, BORTNER CD, PURDY GD, CIDLOWSKI JA: Intracellular K+ suppresses the activation of apoptosis in lymphocytes. J. Biol. Chem. (1997) 272:30567-30576.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30567-30576
    • Hughes Jr., F.M.1    Bortner, C.D.2    Purdy, G.D.3    Cidlowski, J.A.4
  • 258
    • 0032865345 scopus 로고    scopus 로고
    • Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia
    • GARCIA DE ARRIBA S, FRANKE H, PISSAREK M, NIEBER K, ILLES P: Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia. Neurosci. Lett. (1999) 273:13-16.
    • (1999) Neurosci. Lett. , vol.273 , pp. 13-16
    • Garcia, D.E.1    Arriba, S.2    Franke, H.3    Pissarek, M.4    Nieber, K.5    Illes, P.6
  • 259
    • 0032561722 scopus 로고    scopus 로고
    • Tolbutamide attenuates diazoxide-induced aggravation of hypoxic cell injury
    • PISSAREK M, REICHELT C, KRAUSS GJ, ILLES P: Tolbutamide attenuates diazoxide-induced aggravation of hypoxic cell injury. Brain Res. (1998) 812:164-171.
    • (1998) Brain Res. , vol.812 , pp. 164-171
    • Pissarek, M.1    Reichelt, C.2    Krauss, G.J.3    Illes, P.4
  • 260
    • 0030892360 scopus 로고    scopus 로고
    • Activation of ATP-sensitive potassium channels decreases neuronal injury caused by chemical hypoxia
    • WIND T, PREHN JH, PERUCHE B, KRIEGLSTEIN J: Activation of ATP-sensitive potassium channels decreases neuronal injury caused by chemical hypoxia. Brain Res. (1997) 751:295-299.
    • (1997) Brain Res. , vol.751 , pp. 295-299
    • Wind, T.1    Prehn, J.H.2    Peruche, B.3    Krieglstein, J.4
  • 261
    • 0032727351 scopus 로고    scopus 로고
    • Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs
    • DOMOKI F, PERCIACCANTE JV, VELTKAMP R, BARI F, BUSIJA DW: Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs. Stroke (1999) 30:2713-2718.
    • (1999) Stroke , vol.30 , pp. 2713-2718
    • Domoki, F.1    Perciaccante, J.V.2    Veltkamp, R.3    Bari, F.4    Busija, D.W.5
  • 262
    • 0033397736 scopus 로고    scopus 로고
    • Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: Involvement of adenosine A1 receptors and K(ATP) channels
    • PLAMONDON H, BLONDEAU N, HEURTEAUX C, LAZDUNSKI M: Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and K(ATP) channels. J. Cereb. Blood Flow Metab. (1999) 19:1296-1308.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 1296-1308
    • Plamondon, H.1    Blondeau, N.2    Heurteaux, C.3    Lazdunski, M.4
  • 263
    • 0029070496 scopus 로고
    • Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro
    • MALETIC-SAVATIC M, LENN NJ, TRIMMER JS: Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J. Neurosci. (1995) 15:3840-3851.
    • (1995) J. Neurosci. , vol.15 , pp. 3840-3851
    • Maletic-Savatic, M.1    Lenn, N.J.2    Trimmer, J.S.3
  • 264
    • 0028965645 scopus 로고
    • Potassium and calcium channels in lymphocytes
    • LEWIS RS, CAHALAN MD: Potassium and calcium channels in lymphocytes. Ann. Rev. Immunol. (1995) 13:623-653.
    • (1995) Ann. Rev. Immunol. , vol.13 , pp. 623-653
    • Lewis, R.S.1    Cahalan, M.D.2
  • 265
    • 0033624616 scopus 로고    scopus 로고
    • ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons
    • NADEAU H, MCKINNEY S, ANDERSON DJ, LESTER HA: ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. J. Neurophysiol. (2000) 84:1062-1075.
    • (2000) J. Neurophysiol. , vol.84 , pp. 1062-1075
    • Nadeau, H.1    McKinney, S.2    Anderson, D.J.3    Lester, H.A.4
  • 266
    • 0031157738 scopus 로고    scopus 로고
    • Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo
    • KOO GC, BLAKE JT, TALENTO A et al: Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. J. Immunol. (1997) 158:5120-5128.
    • (1997) J. Immunol. , vol.158 , pp. 5120-5128
    • Koo, G.C.1    Blake, J.T.2    Talento, A.3
  • 267
    • 17444453850 scopus 로고    scopus 로고
    • Correolide and deriva tives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels
    • KOO GC, BLAKE JT, SHAHK et al: Correolide and deriva tives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels. Cell Immunol. (1999) 197:99-107.
    • (1999) Cell Immunol. , vol.197 , pp. 99-107
    • Koo, G.C.1    Blake, J.T.2    Et Al, S.3
  • 268
    • 0032970140 scopus 로고    scopus 로고
    • Functional and molecular aspects of voltage-gated K channel beta subunits
    • PONGS O, LEICHER T, BERGER M et al: Functional and molecular aspects of voltage-gated K channel beta subunits. Ann. NY Acad .Sci. (1999) 868:345-355.
    • (1999) Ann. NY Acad .Sci. , vol.868 , pp. 345-355
    • Pongs, O.1    Leicher, T.2    Berger, M.3
  • 269
    • 0030855840 scopus 로고    scopus 로고
    • K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons
    • HOFFMAN DA, MAGEE JC, COLBERT CM, JOHNSTON D: K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature (1997) 387:869-875.
    • (1997) Nature , vol.387 , pp. 869-875
    • Hoffman, D.A.1    Magee, J.C.2    Colbert, C.M.3    Johnston, D.4
  • 270
    • 0034598810 scopus 로고    scopus 로고
    • Modulation of A-type potassium channels by a family of calcium sensors
    • AN WF, BOWLBY MR, BETTY M et al: Modulation of A-type potassium channels by a family of calcium sensors Nature. 2000, 403, 553-556.
    • (2000) Nature , vol.403 , pp. 553-556
    • Wf, A.N.1    Bowlby, M.R.2    Betty, M.3
  • 271
    • 0031789088 scopus 로고    scopus 로고
    • Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen
    • YOUNG K, LIN S, SUN L et al: Identification of a calcium channel modulator using a high throughput yeast two-hybrid screen. NatureBiotechnol. (1998) 16:946-950.
    • (1998) NatureBiotechnol. , vol.16 , pp. 946-950
    • Young, K.1    Lin, S.2    Sun, L.3
  • 272
    • 80052080439 scopus 로고    scopus 로고
    • Investigation of Kv4.3/KChip1 interations using a luciferas based yeast two-hybrid (YTH) system
    • NIEUWENHUIJSEN B, CAO J, RHODES K, YOUNG KH: Investigation of Kv4.3/KChip1 interations using a luciferas based yeast two-hybrid (YTH) system. Soc Neurosci. Abstr. (2000) 26:614.
    • (2000) Soc Neurosci. Abstr. , vol.26 , pp. 614
    • Nieuwenhuijsen, B.1    Cao, J.2    Rhodes, K.3    Young, K.H.4
  • 273
    • 0003319212 scopus 로고    scopus 로고
    • Targeting acute focal stroke with an opener ofMaxi-K potassium channels: BMS-204352 (MaxiPost)
    • GRIBKOFF VK, STARRETT JE, HEWAWASAM P et al: Targeting acute focal stroke with an opener ofMaxi-K potassium channels: BMS-204352 (MaxiPost). Soc. Neurosci. Abstr. (2000) 26:183.
    • (2000) Soc. Neurosci. Abstr. , vol.26 , pp. 183
    • Gribkoff, V.K.1    Starrett, J.E.2    Hewawasam, P.3
  • 274
    • 0034046898 scopus 로고    scopus 로고
    • Pharmacological and molecular characterization of glutamate receptors in the MIN6 pancreatic beta-cell line
    • MORLEY P, MACLEAN S, GENDRON TF et al: Pharmacological and molecular characterization of glutamate receptors in the MIN6 pancreatic beta-cell line. Neurol Res. (2000) 22:379-385.
    • (2000) Neurol Res. , vol.22 , pp. 379-385
    • Morley, P.1    MacLean, S.2    Gendron, T.F.3
  • 275
    • 0034023265 scopus 로고    scopus 로고
    • Potential target sites in peripheral tissues for excitatory neurotransmission and excitotoxicity
    • GILL SS, MUELLER RW, MCGUIRE PF, PULIDO OM: Potential target sites in peripheral tissues for excitatory neurotransmission and excitotoxicity. Toxicol Pathol. (2000) 28:277-284.
    • (2000) Toxicol Pathol. , vol.28 , pp. 277-284
    • Gill, S.S.1    Mueller, R.W.2    McGuire, P.F.3    Pulido, O.M.4
  • 276
    • 0033556249 scopus 로고    scopus 로고
    • Immunochemical localization of the metabotropic glutamate receptors in the rat heart
    • GILL SS, PULIDO OM, MUELLER RW, MCGUIRE PF Immunochemical localization of the metabotropic glutamate receptors in the rat heart. Brain Res. Bull. (1999) 48:143-146.
    • (1999) Brain Res. Bull. , vol.48 , pp. 143-146
    • Gill, S.S.1    Pulido, O.M.2    Mueller, R.W.3    McGuire, P.F.4
  • 277
    • 0032527491 scopus 로고    scopus 로고
    • Molecular and immunochemical characterization of the ionotropic glutamate receptors in the rat heart
    • GILL SS, PULIDO OM, MUELLER RW, MCGUIRE PF: Molecular and immunochemical characterization of the ionotropic glutamate receptors in the rat heart. Brain Res. Bull. (1998) 46:429-434.
    • (1998) Brain Res. Bull. , vol.46 , pp. 429-434
    • Gill, S.S.1    Pulido, O.M.2    Mueller, R.W.3    McGuire, P.F.4
  • 278
    • 0034602266 scopus 로고    scopus 로고
    • Expression of functional metabotropic glutamate receptors in primary cultured rat osteoblasts. Cross-talk with N-methyl-D-aspartate receptors
    • GU Y, PUBLICOVER SJ: Expression of functional metabotropic glutamate receptors in primary cultured rat osteoblasts. Cross-talk with N-methyl-D-aspartate receptors. J. Biol. Chem. (2000) 275:34252-34259.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34252-34259
    • U, Y.G.1    Publicover, S.J.2
  • 279
    • 0345581359 scopus 로고    scopus 로고
    • Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells
    • LAKETIC-LJUBOJEVIC I, SUVA LJ, MAATHUIS FJ, SANDERS D, SKERRY TM: Functional characterization of N-methyl-D-aspartic acid-gated channels in bone cells. Bone (1999) 25:631-637.
    • (1999) Bone , vol.25 , pp. 631-637
    • Laketic-Ljubojevic, I.1    Suva, L.J.2    Maathuis, F.J.3    Sanders, D.4    Skerry, T.M.5
  • 280
    • 0033860051 scopus 로고    scopus 로고
    • Ligand-gated ion channel interac tions with cytoskeletal and signaling proteins
    • SHENG M, PAK DT: Ligand-gated ion channel interac tions with cytoskeletal and signaling proteins. Ann. Rev. Physiol. (2000) 62:755-778.
    • (2000) Ann. Rev. Physiol. , vol.62 , pp. 755-778
    • Sheng, M.1    Pak, D.T.2
  • 281
    • 0033546347 scopus 로고    scopus 로고
    • Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
    • SATTLER R, XIONG Z, LU WY, HAFNER M, MACDONALD JF, TYMIANSKI M: Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science (1999) 284:1845-1848.
    • (1999) Science , vol.284 , pp. 1845-1848
    • Sattler, R.1    Xiong, Z.2    Wy, L.U.3    Hafner, M.4    MacDonald, J.F.5    Tymianski, M.6


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