-
1
-
-
0001933595
-
Neurotoxicity of excitatory amino acids
-
E.G. McGeer, J.W. Olney & P.L. McGeer, Eds. Raven Press. New York
-
1. Olney, J.W. 1978. Neurotoxicity of excitatory amino acids. In Kainic Acid as a Tool in Neurobiology. E.G. McGeer, J.W. Olney & P.L. McGeer, Eds.: 37-70. Raven Press. New York.
-
(1978)
Kainic Acid as a Tool in Neurobiology
, pp. 37-70
-
-
Olney, J.W.1
-
2
-
-
0025396451
-
Do NMDA antagonists protect against cerebral ischemia: Are clinical trials warranted?
-
2. Buchan, A.M. 1990. Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cerebrovasc. Brain Metab. Rev. 2: 1-26.
-
(1990)
Cerebrovasc. Brain Metab. Rev.
, vol.2
, pp. 1-26
-
-
Buchan, A.M.1
-
3
-
-
0009051401
-
Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists
-
G. Lubec & G.A. Rosenthal, Eds. Escom Publishers. Amsterdam
-
3. Chapman, A.G., J.H. Swann et al. 1990. Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists. In Amino Acids: Chemistry, Biology and Medicine. G. Lubec & G.A. Rosenthal, Eds.: 219-232. Escom Publishers. Amsterdam.
-
(1990)
Amino Acids: Chemistry, Biology and Medicine
, pp. 219-232
-
-
Chapman, A.G.1
Swann, J.H.2
-
4
-
-
0027958824
-
Therapeutic potential of PCP receptor ligands
-
4. Gee, K.R. 1994. Therapeutic potential of PCP receptor ligands. Exp. Opin. Invest. Drugs 3: 1021-1030.
-
(1994)
Exp. Opin. Invest. Drugs
, vol.3
, pp. 1021-1030
-
-
Gee, K.R.1
-
5
-
-
0024405516
-
Selective vulnerability of the brain: New insights into the pathophysiology of stroke
-
5. Collins, R.C., B.H. Dobkin et al. 1989. Selective vulnerability of the brain: new insights into the pathophysiology of stroke. Ann. Int. Med. 110: 992-1000.
-
(1989)
Ann. Int. Med.
, vol.110
, pp. 992-1000
-
-
Collins, R.C.1
Dobkin, B.H.2
-
6
-
-
0027176541
-
Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3-benzodiazepines
-
6. Rogawski, M.A. 1993. Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol. 14: 325-331.
-
(1993)
Trends Pharmacol.
, vol.14
, pp. 325-331
-
-
Rogawski, M.A.1
-
7
-
-
0030483729
-
Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists
-
7. Grant, K.A., G. Colombo et al. 1996. Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology 35: 1709-1719.
-
(1996)
Neuropharmacology
, vol.35
, pp. 1709-1719
-
-
Grant, K.A.1
Colombo, G.2
-
8
-
-
0001932275
-
Preclinical and clinical aspects of remacemide hydrochloride
-
P. Herrling, Ed. Academic Press. New York
-
8. Palmer, G.C. & J.B. Hutchison. 1997. Preclinical and clinical aspects of remacemide hydrochloride. In Excitatory Amino Acids-Clinical Results with Antagonists. P. Herrling, Ed.: 109-120. Academic Press. New York.
-
(1997)
Excitatory Amino Acids-Clinical Results with Antagonists
, pp. 109-120
-
-
Palmer, G.C.1
Hutchison, J.B.2
-
9
-
-
0008998047
-
Preclinical neruoprotectant efficacy of NPS 1506, a novel NMDA receptor antagonist
-
International Business Communications. Southborough, MA
-
9. Mueller, A.L. 1998. Preclinical neruoprotectant efficacy of NPS 1506, a novel NMDA receptor antagonist. In Glutamate Pharmacology Therapeutic Implications. International Business Communications. Southborough, MA.
-
(1998)
Glutamate Pharmacology Therapeutic Implications
-
-
Mueller, A.L.1
-
10
-
-
0030828561
-
Low affinity NMDA receptor antagonists, the neuroprotective potential of ARL 15896AR
-
10. Palmer, G.C., J.A. Miller et al. 1997. Low affinity NMDA receptor antagonists, the neuroprotective potential of ARL 15896AR. Ann. N.Y. Acad. Sci. 825: 220-231.
-
(1997)
Ann. N.Y. Acad. Sci.
, vol.825
, pp. 220-231
-
-
Palmer, G.C.1
Miller, J.A.2
-
11
-
-
0008963202
-
Cytokine production in the brain following closed head injury: Dexanabinol (HU-211), a neuroprotective agent, in normal volunteers
-
11. Shohami, E., R. Gallily et al. 1997. Cytokine production in the brain following closed head injury: Dexanabinol (HU-211), a neuroprotective agent, in normal volunteers. Int. J. Clin. Pharmacol. Ther. 35: 361-365.
-
(1997)
Int. J. Clin. Pharmacol. Ther.
, vol.35
, pp. 361-365
-
-
Shohami, E.1
Gallily, R.2
-
12
-
-
0032933069
-
[S]-AR-R 15896AR, a novel anticonvulsant: Acute safety, pharmacokinetic, and pharmacodynamic properties
-
12. Palmer, G.C., R.J. Murray et al. 1999. [S]-AR-R 15896AR, a novel anticonvulsant: acute safety, pharmacokinetic, and pharmacodynamic properties. J. Pharmacol. Exp. Ther. 288: 121-132.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 121-132
-
-
Palmer, G.C.1
Murray, R.J.2
-
13
-
-
0030006907
-
Remacemide hydrochloride and ARL 15896AR lack abuse potential: Additional differences from other uncompetitive NMDA antagonists
-
13. Hudzik, T.J., L. Freedman et al. 1996. Remacemide hydrochloride and ARL 15896AR lack abuse potential: additional differences from other uncompetitive NMDA antagonists. Epilepsia 37: 544-550.
-
(1996)
Epilepsia
, vol.37
, pp. 544-550
-
-
Hudzik, T.J.1
Freedman, L.2
-
14
-
-
0029096111
-
Effects of anticonvulsants in a novel operant learning paradigm in rats: Comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents
-
14. Hudzik, T.J. & G.C. Palmer. 1995. Effects of anticonvulsants in a novel operant learning paradigm in rats: comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents. Epilepsy Res. 21: 183-193.
-
(1995)
Epilepsy Res.
, vol.21
, pp. 183-193
-
-
Hudzik, T.J.1
Palmer, G.C.2
-
15
-
-
0009052019
-
Low affinity non-competitive (LANC) NMDA antagonists do not impair memory and have reduced behavioral performance effects compared to other classes of NMDA antagonists
-
15. Widzowski, D., P. Bialobok et al. 1997. Low affinity non-competitive (LANC) NMDA antagonists do not impair memory and have reduced behavioral performance effects compared to other classes of NMDA antagonists. Soc. Neurosci. 23: 1758.
-
(1997)
Soc. Neurosci.
, vol.23
, pp. 1758
-
-
Widzowski, D.1
Bialobok, P.2
-
16
-
-
0028971863
-
N-Methyl-D-aspartate-or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR
-
16. Black, M.A., R. Tremblay et al. 1995. N-Methyl-D-aspartate-or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR. J. Neurochem. 65: 2170-2177.
-
(1995)
J. Neurochem.
, vol.65
, pp. 2170-2177
-
-
Black, M.A.1
Tremblay, R.2
-
17
-
-
0028873061
-
Regional variations in the pharmacology of NMDA receptor channel blockers: Implications for therapeutic potential
-
17. Porter, R.H.P. & J.T. Greenamyre. 1995. Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. J. Neurochem. 64: 614-623.
-
(1995)
J. Neurochem.
, vol.64
, pp. 614-623
-
-
Porter, R.H.P.1
Greenamyre, J.T.2
-
18
-
-
0029671238
-
ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: Neuroprotection against mitochondrial metabolic toxicity and regional pharmacology
-
18. Greene, J.G., R.H. Porter et al. 1996. ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology. Exp. Neurol. 137: 66-72.
-
(1996)
Exp. Neurol.
, vol.137
, pp. 66-72
-
-
Greene, J.G.1
Porter, R.H.2
-
19
-
-
0030946384
-
NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology
-
19. Monaghan, D.T. & H. Larsen. 1997. NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology. J. Pharmacol. Exp. Ther. 280: 614-620.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.280
, pp. 614-620
-
-
Monaghan, D.T.1
Larsen, H.2
-
20
-
-
0030764907
-
Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices
-
20. Small, D.L., M.O. Poulter et al. 1997. Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices. Neurosci. Lett. 232: 87-90.
-
(1997)
Neurosci. Lett.
, vol.232
, pp. 87-90
-
-
Small, D.L.1
Poulter, M.O.2
-
21
-
-
0008962351
-
Do excitatory amino acid receptors play a role in neuronal degeneration following acute stroke?
-
International Business Communications. Southborough, MA
-
21. Gill, R., A. Bourson et al. 1998. Do excitatory amino acid receptors play a role in neuronal degeneration following acute stroke? In Glutamate Pharmacology Therapeutic Implications. International Business Communications. Southborough, MA.
-
(1998)
Glutamate Pharmacology Therapeutic Implications
-
-
Gill, R.1
Bourson, A.2
-
22
-
-
0031020529
-
Trapping channel block of NMDA-activated responses by amantadine and memantine
-
22. Blanpied, T.A., F.A. Boeckman et al. 1997. Trapping channel block of NMDA-activated responses by amantadine and memantine. J. Neurophysiol. 77: 309-323.
-
(1997)
J. Neurophysiol.
, vol.77
, pp. 309-323
-
-
Blanpied, T.A.1
Boeckman, F.A.2
-
23
-
-
0030593913
-
Study of potency, kinetics of block and toxicity of NMDA receptor antagonists using fura-2
-
23. Black, M., T. Lanthorn et al. 1996. Study of potency, kinetics of block and toxicity of NMDA receptor antagonists using fura-2. Eur. J. Pharmacol. 317: 377-381.
-
(1996)
Eur. J. Pharmacol.
, vol.317
, pp. 377-381
-
-
Black, M.1
Lanthorn, T.2
-
24
-
-
0030924648
-
Antagonism of N-methyl-D-aspartate-evoked currents in rat cortical cultures by ARL 15896AR
-
24. Mealing, G.A.R., T.H. Lanthorn et al. 1997. Antagonism of N-methyl-D-aspartate-evoked currents in rat cortical cultures by ARL 15896AR. J. Pharmacol. Exp. Ther. 281: 376-383.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.281
, pp. 376-383
-
-
Mealing, G.A.R.1
Lanthorn, T.H.2
-
25
-
-
0032934209
-
Differences in the degree of trapping of low affinity uncompetitive NMDA receptor antagonists with similar kinetics of block
-
25. Mealing, G.A.R., T.H. Lanthorn et al. 1999. Differences in the degree of trapping of low affinity uncompetitive NMDA receptor antagonists with similar kinetics of block. J. Pharmacol. Exp. Ther. 288: 204-210.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 204-210
-
-
Mealing, G.A.R.1
Lanthorn, T.H.2
-
26
-
-
0029670420
-
Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite
-
26. Subramanian, S., S.D. Donevan et al. 1996. Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J. Pharmacol. Exp. Ther. 276: 161-168.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.276
, pp. 161-168
-
-
Subramanian, S.1
Donevan, S.D.2
-
27
-
-
0027104318
-
The anticonvulsant (±)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCI) selectively blocks NMDA-activated current in cultured rat hippocampal neurones: Kinetic analysis and comparison with dizocilpine
-
27. Jones, S.M & M.A. Rogawski. 1992. The anticonvulsant (±)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCI) selectively blocks NMDA-activated current in cultured rat hippocampal neurones: kinetic analysis and comparison with dizocilpine. Mol. Neuropharmacol. 2: 303-310.
-
(1992)
Mol. Neuropharmacol.
, vol.2
, pp. 303-310
-
-
Jones, S.M.1
Rogawski, M.A.2
-
28
-
-
0024450953
-
Antiepileptic drug action
-
28. MacDonald, R.L. 1989. Antiepileptic drug action. Epilepsia 30(Suppl. 1): S19-S28.
-
(1989)
Epilepsia
, vol.30
, Issue.SUPPL. 1
-
-
MacDonald, R.L.1
-
29
-
-
0027314582
-
Sigma receptor mediated emetic responses in pigeons: Agonists, antagonists and modifiers
-
29. Hudzik, T.J, B.R. DeCosta et al. 1993. Sigma receptor mediated emetic responses in pigeons: agonists, antagonists and modifiers. Eur. J. Pharmacol. 236: 279-287.
-
(1993)
Eur. J. Pharmacol.
, vol.236
, pp. 279-287
-
-
Hudzik, T.J.1
DeCosta, B.R.2
-
30
-
-
0025801234
-
Reorganization of the cytoskeleton in rat neurons following stimulation with excitatory amino acids in vitro
-
30. Bigot, D., A. Matus et al. 1991. Reorganization of the cytoskeleton in rat neurons following stimulation with excitatory amino acids in vitro. Eur. J. Neurosci. 3: 551-558.
-
(1991)
Eur. J. Neurosci.
, vol.3
, pp. 551-558
-
-
Bigot, D.1
Matus, A.2
-
31
-
-
0031038495
-
Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro
-
31. Faddis, B.T., M.J. Hasbani et al. 1997. Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro. J. Neurosci. 17: 951-959.
-
(1997)
J. Neurosci.
, vol.17
, pp. 951-959
-
-
Faddis, B.T.1
Hasbani, M.J.2
-
32
-
-
0032811991
-
AR-R 15896AR blocks the early NMDA-induced loss of MAP2 in primary cortical cultures
-
32. Laferiere, N.B., R. Tremblay et al. 1999. AR-R 15896AR blocks the early NMDA-induced loss of MAP2 in primary cortical cultures. Neurol. Res. 21: 524-528.
-
(1999)
Neurol. Res.
, vol.21
, pp. 524-528
-
-
Laferiere, N.B.1
Tremblay, R.2
-
33
-
-
0029811105
-
Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
-
33. Giulian, D.L., J. Haverkamp et al. 1996. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J. Neurosci. 16: 6021-6037.
-
(1996)
J. Neurosci.
, vol.16
, pp. 6021-6037
-
-
Giulian, D.L.1
Haverkamp, J.2
-
34
-
-
0009046848
-
2+ entry into rat cerebellar granule cells in vitro
-
2+ entry into rat cerebellar granule cells in vitro. Soc. Neurosci. 24: 979.
-
(1998)
Soc. Neurosci.
, vol.24
, pp. 979
-
-
Cross, A.J.1
Green, A.R.2
-
35
-
-
0009004453
-
The effects of ARL 15896 on in vitro hypoxia/ hypoglycemia-induced amino acid release from rat cortical slices
-
Poster # 33.25
-
35. Johns, L., A.J. Sinclair et al. 1998. The effects of ARL 15896 on in vitro hypoxia/ hypoglycemia-induced amino acid release from rat cortical slices. Forum Eur. Neurosci. Poster # 33.25.
-
(1998)
Forum Eur. Neurosci.
-
-
Johns, L.1
Sinclair, A.J.2
-
36
-
-
0029145734
-
Neuroprotective actions of 2-amino-N-(1,2-diphenylethyl)-acetamide hydrochloride (FPL 13950) in animal models of hypoxia and global ischemia
-
36. Palmer, G.C., E.F. Cregan et al. 1995. Neuroprotective actions of 2-amino-N-(1,2-diphenylethyl)-acetamide hydrochloride (FPL 13950) in animal models of hypoxia and global ischemia. J. Pharmacol. Exp. Ther. 274: 991-1000.
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.274
, pp. 991-1000
-
-
Palmer, G.C.1
Cregan, E.F.2
-
37
-
-
0029549250
-
Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride
-
37. Palmer, G.C., E.F. Cregan et al. 1995. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann. N.Y. Acad. Sci. 576: 236-247.
-
(1995)
Ann. N.Y. Acad. Sci.
, vol.576
, pp. 236-247
-
-
Palmer, G.C.1
Cregan, E.F.2
-
38
-
-
15644379077
-
[(S)-alpha-phenyl-2-pyridine-ethanamine dihydrochloride], a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia
-
38. Cregan, E.F., J. Peeling et al. 1997. [(S)-Alpha-phenyl-2-pyridine-ethanamine dihydrochloride], a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia. J. Pharmacol. Exp. Ther. 283: 1412-1424.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.283
, pp. 1412-1424
-
-
Cregan, E.F.1
Peeling, J.2
-
39
-
-
0032583237
-
Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats
-
39. Preston, E., J. Webster et al. 1998. Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats. Brain Res. 813: 191-194.
-
(1998)
Brain Res.
, vol.813
, pp. 191-194
-
-
Preston, E.1
Webster, J.2
-
40
-
-
0026508278
-
A new model of temporary focal neocortical ischemia in the rat
-
40. Buchan, A.M., D. Xue et al. 1992. A new model of temporary focal neocortical ischemia in the rat. Stroke 23: 273-279.
-
(1992)
Stroke
, vol.23
, pp. 273-279
-
-
Buchan, A.M.1
Xue, D.2
-
41
-
-
0031914497
-
The problem of assessing effective neuroprotection in experimental cerebral ischemia
-
41. Corbett, D. & S. Nurse. 1998. The problem of assessing effective neuroprotection in experimental cerebral ischemia. Prog. Neurobiol. 54: 531-548.
-
(1998)
Prog. Neurobiol.
, vol.54
, pp. 531-548
-
-
Corbett, D.1
Nurse, S.2
-
42
-
-
0009002323
-
AR-R 15896AR reduces cerebral infarct volume following focal ischemia in cat
-
In press
-
42. Sutherland, G.R., J.T. Perron et al. AR-R 15896AR reduces cerebral infarct volume following focal ischemia in cat. J. Stroke Cerebrovasc. Dis. In press.
-
J. Stroke Cerebrovasc. Dis.
-
-
Sutherland, G.R.1
Perron, J.T.2
|