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Volumn 890, Issue , 1999, Pages 406-420

The low-affinity use-dependent NMDA receptor antagonist AR-R 15896AR. An update of progress in stroke

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; BUDIPINE; DIZOCILPINE; EXCITATORY AMINO ACID; FPL 15853; LANICEMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PIPERIDINE DERIVATIVE; RECEPTOR SUBUNIT; REMACEMIDE; UNCLASSIFIED DRUG;

EID: 0033403301     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb08020.x     Document Type: Conference Paper
Times cited : (17)

References (42)
  • 1
    • 0001933595 scopus 로고
    • Neurotoxicity of excitatory amino acids
    • E.G. McGeer, J.W. Olney & P.L. McGeer, Eds. Raven Press. New York
    • 1. Olney, J.W. 1978. Neurotoxicity of excitatory amino acids. In Kainic Acid as a Tool in Neurobiology. E.G. McGeer, J.W. Olney & P.L. McGeer, Eds.: 37-70. Raven Press. New York.
    • (1978) Kainic Acid as a Tool in Neurobiology , pp. 37-70
    • Olney, J.W.1
  • 2
    • 0025396451 scopus 로고
    • Do NMDA antagonists protect against cerebral ischemia: Are clinical trials warranted?
    • 2. Buchan, A.M. 1990. Do NMDA antagonists protect against cerebral ischemia: are clinical trials warranted? Cerebrovasc. Brain Metab. Rev. 2: 1-26.
    • (1990) Cerebrovasc. Brain Metab. Rev. , vol.2 , pp. 1-26
    • Buchan, A.M.1
  • 3
    • 0009051401 scopus 로고
    • Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists
    • G. Lubec & G.A. Rosenthal, Eds. Escom Publishers. Amsterdam
    • 3. Chapman, A.G., J.H. Swann et al. 1990. Cerebroprotective and anticonvulsant action of competitive and non-competitive NMDA antagonists. In Amino Acids: Chemistry, Biology and Medicine. G. Lubec & G.A. Rosenthal, Eds.: 219-232. Escom Publishers. Amsterdam.
    • (1990) Amino Acids: Chemistry, Biology and Medicine , pp. 219-232
    • Chapman, A.G.1    Swann, J.H.2
  • 4
    • 0027958824 scopus 로고
    • Therapeutic potential of PCP receptor ligands
    • 4. Gee, K.R. 1994. Therapeutic potential of PCP receptor ligands. Exp. Opin. Invest. Drugs 3: 1021-1030.
    • (1994) Exp. Opin. Invest. Drugs , vol.3 , pp. 1021-1030
    • Gee, K.R.1
  • 5
    • 0024405516 scopus 로고
    • Selective vulnerability of the brain: New insights into the pathophysiology of stroke
    • 5. Collins, R.C., B.H. Dobkin et al. 1989. Selective vulnerability of the brain: new insights into the pathophysiology of stroke. Ann. Int. Med. 110: 992-1000.
    • (1989) Ann. Int. Med. , vol.110 , pp. 992-1000
    • Collins, R.C.1    Dobkin, B.H.2
  • 6
    • 0027176541 scopus 로고
    • Therapeutic potential of excitatory amino acid antagonists: Channel blockers and 2,3-benzodiazepines
    • 6. Rogawski, M.A. 1993. Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol. 14: 325-331.
    • (1993) Trends Pharmacol. , vol.14 , pp. 325-331
    • Rogawski, M.A.1
  • 7
    • 0030483729 scopus 로고    scopus 로고
    • Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists
    • 7. Grant, K.A., G. Colombo et al. 1996. Dizocilpine-like discriminative stimulus effects of low-affinity uncompetitive NMDA antagonists. Neuropharmacology 35: 1709-1719.
    • (1996) Neuropharmacology , vol.35 , pp. 1709-1719
    • Grant, K.A.1    Colombo, G.2
  • 8
    • 0001932275 scopus 로고    scopus 로고
    • Preclinical and clinical aspects of remacemide hydrochloride
    • P. Herrling, Ed. Academic Press. New York
    • 8. Palmer, G.C. & J.B. Hutchison. 1997. Preclinical and clinical aspects of remacemide hydrochloride. In Excitatory Amino Acids-Clinical Results with Antagonists. P. Herrling, Ed.: 109-120. Academic Press. New York.
    • (1997) Excitatory Amino Acids-Clinical Results with Antagonists , pp. 109-120
    • Palmer, G.C.1    Hutchison, J.B.2
  • 9
    • 0008998047 scopus 로고    scopus 로고
    • Preclinical neruoprotectant efficacy of NPS 1506, a novel NMDA receptor antagonist
    • International Business Communications. Southborough, MA
    • 9. Mueller, A.L. 1998. Preclinical neruoprotectant efficacy of NPS 1506, a novel NMDA receptor antagonist. In Glutamate Pharmacology Therapeutic Implications. International Business Communications. Southborough, MA.
    • (1998) Glutamate Pharmacology Therapeutic Implications
    • Mueller, A.L.1
  • 10
    • 0030828561 scopus 로고    scopus 로고
    • Low affinity NMDA receptor antagonists, the neuroprotective potential of ARL 15896AR
    • 10. Palmer, G.C., J.A. Miller et al. 1997. Low affinity NMDA receptor antagonists, the neuroprotective potential of ARL 15896AR. Ann. N.Y. Acad. Sci. 825: 220-231.
    • (1997) Ann. N.Y. Acad. Sci. , vol.825 , pp. 220-231
    • Palmer, G.C.1    Miller, J.A.2
  • 11
    • 0008963202 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: Dexanabinol (HU-211), a neuroprotective agent, in normal volunteers
    • 11. Shohami, E., R. Gallily et al. 1997. Cytokine production in the brain following closed head injury: Dexanabinol (HU-211), a neuroprotective agent, in normal volunteers. Int. J. Clin. Pharmacol. Ther. 35: 361-365.
    • (1997) Int. J. Clin. Pharmacol. Ther. , vol.35 , pp. 361-365
    • Shohami, E.1    Gallily, R.2
  • 12
    • 0032933069 scopus 로고    scopus 로고
    • [S]-AR-R 15896AR, a novel anticonvulsant: Acute safety, pharmacokinetic, and pharmacodynamic properties
    • 12. Palmer, G.C., R.J. Murray et al. 1999. [S]-AR-R 15896AR, a novel anticonvulsant: acute safety, pharmacokinetic, and pharmacodynamic properties. J. Pharmacol. Exp. Ther. 288: 121-132.
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 121-132
    • Palmer, G.C.1    Murray, R.J.2
  • 13
    • 0030006907 scopus 로고    scopus 로고
    • Remacemide hydrochloride and ARL 15896AR lack abuse potential: Additional differences from other uncompetitive NMDA antagonists
    • 13. Hudzik, T.J., L. Freedman et al. 1996. Remacemide hydrochloride and ARL 15896AR lack abuse potential: additional differences from other uncompetitive NMDA antagonists. Epilepsia 37: 544-550.
    • (1996) Epilepsia , vol.37 , pp. 544-550
    • Hudzik, T.J.1    Freedman, L.2
  • 14
    • 0029096111 scopus 로고
    • Effects of anticonvulsants in a novel operant learning paradigm in rats: Comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents
    • 14. Hudzik, T.J. & G.C. Palmer. 1995. Effects of anticonvulsants in a novel operant learning paradigm in rats: comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents. Epilepsy Res. 21: 183-193.
    • (1995) Epilepsy Res. , vol.21 , pp. 183-193
    • Hudzik, T.J.1    Palmer, G.C.2
  • 15
    • 0009052019 scopus 로고    scopus 로고
    • Low affinity non-competitive (LANC) NMDA antagonists do not impair memory and have reduced behavioral performance effects compared to other classes of NMDA antagonists
    • 15. Widzowski, D., P. Bialobok et al. 1997. Low affinity non-competitive (LANC) NMDA antagonists do not impair memory and have reduced behavioral performance effects compared to other classes of NMDA antagonists. Soc. Neurosci. 23: 1758.
    • (1997) Soc. Neurosci. , vol.23 , pp. 1758
    • Widzowski, D.1    Bialobok, P.2
  • 16
    • 0028971863 scopus 로고
    • N-Methyl-D-aspartate-or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR
    • 16. Black, M.A., R. Tremblay et al. 1995. N-Methyl-D-aspartate-or glutamate-mediated toxicity in cultured rat cortical neurons is antagonized by FPL 15896AR. J. Neurochem. 65: 2170-2177.
    • (1995) J. Neurochem. , vol.65 , pp. 2170-2177
    • Black, M.A.1    Tremblay, R.2
  • 17
    • 0028873061 scopus 로고
    • Regional variations in the pharmacology of NMDA receptor channel blockers: Implications for therapeutic potential
    • 17. Porter, R.H.P. & J.T. Greenamyre. 1995. Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. J. Neurochem. 64: 614-623.
    • (1995) J. Neurochem. , vol.64 , pp. 614-623
    • Porter, R.H.P.1    Greenamyre, J.T.2
  • 18
    • 0029671238 scopus 로고    scopus 로고
    • ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: Neuroprotection against mitochondrial metabolic toxicity and regional pharmacology
    • 18. Greene, J.G., R.H. Porter et al. 1996. ARL-15896, a novel N-methyl-D-aspartate receptor ion channel antagonist: neuroprotection against mitochondrial metabolic toxicity and regional pharmacology. Exp. Neurol. 137: 66-72.
    • (1996) Exp. Neurol. , vol.137 , pp. 66-72
    • Greene, J.G.1    Porter, R.H.2
  • 19
    • 0030946384 scopus 로고    scopus 로고
    • NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology
    • 19. Monaghan, D.T. & H. Larsen. 1997. NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology. J. Pharmacol. Exp. Ther. 280: 614-620.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 614-620
    • Monaghan, D.T.1    Larsen, H.2
  • 20
    • 0030764907 scopus 로고    scopus 로고
    • Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices
    • 20. Small, D.L., M.O. Poulter et al. 1997. Alteration in NMDA receptor subunit mRNA expression in vulnerable and resistant regions of in vitro ischemic rat hippocampal slices. Neurosci. Lett. 232: 87-90.
    • (1997) Neurosci. Lett. , vol.232 , pp. 87-90
    • Small, D.L.1    Poulter, M.O.2
  • 21
    • 0008962351 scopus 로고    scopus 로고
    • Do excitatory amino acid receptors play a role in neuronal degeneration following acute stroke?
    • International Business Communications. Southborough, MA
    • 21. Gill, R., A. Bourson et al. 1998. Do excitatory amino acid receptors play a role in neuronal degeneration following acute stroke? In Glutamate Pharmacology Therapeutic Implications. International Business Communications. Southborough, MA.
    • (1998) Glutamate Pharmacology Therapeutic Implications
    • Gill, R.1    Bourson, A.2
  • 22
    • 0031020529 scopus 로고    scopus 로고
    • Trapping channel block of NMDA-activated responses by amantadine and memantine
    • 22. Blanpied, T.A., F.A. Boeckman et al. 1997. Trapping channel block of NMDA-activated responses by amantadine and memantine. J. Neurophysiol. 77: 309-323.
    • (1997) J. Neurophysiol. , vol.77 , pp. 309-323
    • Blanpied, T.A.1    Boeckman, F.A.2
  • 23
    • 0030593913 scopus 로고    scopus 로고
    • Study of potency, kinetics of block and toxicity of NMDA receptor antagonists using fura-2
    • 23. Black, M., T. Lanthorn et al. 1996. Study of potency, kinetics of block and toxicity of NMDA receptor antagonists using fura-2. Eur. J. Pharmacol. 317: 377-381.
    • (1996) Eur. J. Pharmacol. , vol.317 , pp. 377-381
    • Black, M.1    Lanthorn, T.2
  • 24
    • 0030924648 scopus 로고    scopus 로고
    • Antagonism of N-methyl-D-aspartate-evoked currents in rat cortical cultures by ARL 15896AR
    • 24. Mealing, G.A.R., T.H. Lanthorn et al. 1997. Antagonism of N-methyl-D-aspartate-evoked currents in rat cortical cultures by ARL 15896AR. J. Pharmacol. Exp. Ther. 281: 376-383.
    • (1997) J. Pharmacol. Exp. Ther. , vol.281 , pp. 376-383
    • Mealing, G.A.R.1    Lanthorn, T.H.2
  • 25
    • 0032934209 scopus 로고    scopus 로고
    • Differences in the degree of trapping of low affinity uncompetitive NMDA receptor antagonists with similar kinetics of block
    • 25. Mealing, G.A.R., T.H. Lanthorn et al. 1999. Differences in the degree of trapping of low affinity uncompetitive NMDA receptor antagonists with similar kinetics of block. J. Pharmacol. Exp. Ther. 288: 204-210.
    • (1999) J. Pharmacol. Exp. Ther. , vol.288 , pp. 204-210
    • Mealing, G.A.R.1    Lanthorn, T.H.2
  • 26
    • 0029670420 scopus 로고    scopus 로고
    • Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite
    • 26. Subramanian, S., S.D. Donevan et al. 1996. Block of the N-methyl-D-aspartate receptor by remacemide and its des-glycine metabolite. J. Pharmacol. Exp. Ther. 276: 161-168.
    • (1996) J. Pharmacol. Exp. Ther. , vol.276 , pp. 161-168
    • Subramanian, S.1    Donevan, S.D.2
  • 27
    • 0027104318 scopus 로고
    • The anticonvulsant (±)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCI) selectively blocks NMDA-activated current in cultured rat hippocampal neurones: Kinetic analysis and comparison with dizocilpine
    • 27. Jones, S.M & M.A. Rogawski. 1992. The anticonvulsant (±)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCI) selectively blocks NMDA-activated current in cultured rat hippocampal neurones: kinetic analysis and comparison with dizocilpine. Mol. Neuropharmacol. 2: 303-310.
    • (1992) Mol. Neuropharmacol. , vol.2 , pp. 303-310
    • Jones, S.M.1    Rogawski, M.A.2
  • 28
    • 0024450953 scopus 로고
    • Antiepileptic drug action
    • 28. MacDonald, R.L. 1989. Antiepileptic drug action. Epilepsia 30(Suppl. 1): S19-S28.
    • (1989) Epilepsia , vol.30 , Issue.SUPPL. 1
    • MacDonald, R.L.1
  • 29
    • 0027314582 scopus 로고
    • Sigma receptor mediated emetic responses in pigeons: Agonists, antagonists and modifiers
    • 29. Hudzik, T.J, B.R. DeCosta et al. 1993. Sigma receptor mediated emetic responses in pigeons: agonists, antagonists and modifiers. Eur. J. Pharmacol. 236: 279-287.
    • (1993) Eur. J. Pharmacol. , vol.236 , pp. 279-287
    • Hudzik, T.J.1    DeCosta, B.R.2
  • 30
    • 0025801234 scopus 로고
    • Reorganization of the cytoskeleton in rat neurons following stimulation with excitatory amino acids in vitro
    • 30. Bigot, D., A. Matus et al. 1991. Reorganization of the cytoskeleton in rat neurons following stimulation with excitatory amino acids in vitro. Eur. J. Neurosci. 3: 551-558.
    • (1991) Eur. J. Neurosci. , vol.3 , pp. 551-558
    • Bigot, D.1    Matus, A.2
  • 31
    • 0031038495 scopus 로고    scopus 로고
    • Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro
    • 31. Faddis, B.T., M.J. Hasbani et al. 1997. Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro. J. Neurosci. 17: 951-959.
    • (1997) J. Neurosci. , vol.17 , pp. 951-959
    • Faddis, B.T.1    Hasbani, M.J.2
  • 32
    • 0032811991 scopus 로고    scopus 로고
    • AR-R 15896AR blocks the early NMDA-induced loss of MAP2 in primary cortical cultures
    • 32. Laferiere, N.B., R. Tremblay et al. 1999. AR-R 15896AR blocks the early NMDA-induced loss of MAP2 in primary cortical cultures. Neurol. Res. 21: 524-528.
    • (1999) Neurol. Res. , vol.21 , pp. 524-528
    • Laferiere, N.B.1    Tremblay, R.2
  • 33
    • 0029811105 scopus 로고    scopus 로고
    • Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia
    • 33. Giulian, D.L., J. Haverkamp et al. 1996. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J. Neurosci. 16: 6021-6037.
    • (1996) J. Neurosci. , vol.16 , pp. 6021-6037
    • Giulian, D.L.1    Haverkamp, J.2
  • 34
    • 0009046848 scopus 로고    scopus 로고
    • 2+ entry into rat cerebellar granule cells in vitro
    • 2+ entry into rat cerebellar granule cells in vitro. Soc. Neurosci. 24: 979.
    • (1998) Soc. Neurosci. , vol.24 , pp. 979
    • Cross, A.J.1    Green, A.R.2
  • 35
    • 0009004453 scopus 로고    scopus 로고
    • The effects of ARL 15896 on in vitro hypoxia/ hypoglycemia-induced amino acid release from rat cortical slices
    • Poster # 33.25
    • 35. Johns, L., A.J. Sinclair et al. 1998. The effects of ARL 15896 on in vitro hypoxia/ hypoglycemia-induced amino acid release from rat cortical slices. Forum Eur. Neurosci. Poster # 33.25.
    • (1998) Forum Eur. Neurosci.
    • Johns, L.1    Sinclair, A.J.2
  • 36
    • 0029145734 scopus 로고
    • Neuroprotective actions of 2-amino-N-(1,2-diphenylethyl)-acetamide hydrochloride (FPL 13950) in animal models of hypoxia and global ischemia
    • 36. Palmer, G.C., E.F. Cregan et al. 1995. Neuroprotective actions of 2-amino-N-(1,2-diphenylethyl)-acetamide hydrochloride (FPL 13950) in animal models of hypoxia and global ischemia. J. Pharmacol. Exp. Ther. 274: 991-1000.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 991-1000
    • Palmer, G.C.1    Cregan, E.F.2
  • 37
    • 0029549250 scopus 로고
    • Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride
    • 37. Palmer, G.C., E.F. Cregan et al. 1995. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann. N.Y. Acad. Sci. 576: 236-247.
    • (1995) Ann. N.Y. Acad. Sci. , vol.576 , pp. 236-247
    • Palmer, G.C.1    Cregan, E.F.2
  • 38
    • 15644379077 scopus 로고    scopus 로고
    • [(S)-alpha-phenyl-2-pyridine-ethanamine dihydrochloride], a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia
    • 38. Cregan, E.F., J. Peeling et al. 1997. [(S)-Alpha-phenyl-2-pyridine-ethanamine dihydrochloride], a low affinity uncompetitive N-methyl-D-aspartic acid antagonist, is effective in rodent models of global and focal ischemia. J. Pharmacol. Exp. Ther. 283: 1412-1424.
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 1412-1424
    • Cregan, E.F.1    Peeling, J.2
  • 39
    • 0032583237 scopus 로고    scopus 로고
    • Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats
    • 39. Preston, E., J. Webster et al. 1998. Lack of evidence for direct involvement of NMDA receptors or polyamines in blood-brain barrier injury after cerebral ischemia in rats. Brain Res. 813: 191-194.
    • (1998) Brain Res. , vol.813 , pp. 191-194
    • Preston, E.1    Webster, J.2
  • 40
    • 0026508278 scopus 로고
    • A new model of temporary focal neocortical ischemia in the rat
    • 40. Buchan, A.M., D. Xue et al. 1992. A new model of temporary focal neocortical ischemia in the rat. Stroke 23: 273-279.
    • (1992) Stroke , vol.23 , pp. 273-279
    • Buchan, A.M.1    Xue, D.2
  • 41
    • 0031914497 scopus 로고    scopus 로고
    • The problem of assessing effective neuroprotection in experimental cerebral ischemia
    • 41. Corbett, D. & S. Nurse. 1998. The problem of assessing effective neuroprotection in experimental cerebral ischemia. Prog. Neurobiol. 54: 531-548.
    • (1998) Prog. Neurobiol. , vol.54 , pp. 531-548
    • Corbett, D.1    Nurse, S.2
  • 42
    • 0009002323 scopus 로고    scopus 로고
    • AR-R 15896AR reduces cerebral infarct volume following focal ischemia in cat
    • In press
    • 42. Sutherland, G.R., J.T. Perron et al. AR-R 15896AR reduces cerebral infarct volume following focal ischemia in cat. J. Stroke Cerebrovasc. Dis. In press.
    • J. Stroke Cerebrovasc. Dis.
    • Sutherland, G.R.1    Perron, J.T.2


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