Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]indeno[1,2-e]pyrazin-8- and-9-carboxylic (acetic) acid AMPA antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 24, 2000, Pages 2749-2754

  Pratt, Jeremy ^a   Jimonet, Patrick ^a   Bohme, Georg Andrees ^a   Boireau, Alain ^a   Damour, Dominique ^a   Debono, Marc Williams ^a   Genevois Borella, Arielle ^a   Randle, John C R ^a,b   Ribeill, Yves ^a,c   Stutzmann, Jean Marie ^a   Vuilhorgne, Marc ^a   Mignani, Serge ^a  

^a SANOFI   (France)

^b VERTEX PHARMACEUTICALS   (United States)

^c Aventis CropScience   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 OXO IMIDAZO[1,2 A]INDENO[1,2 E]PYRAZIN 8 ACETIC ACID; 4 OXO IMIDAZO[1,2 A]INDENO[1,2 E]PYRAZIN 8 CARBOXYLIC ACID; 4 OXO IMIDAZO[1,2 A]INDENO[1,2 E]PYRAZIN 9 ACETIC ACID; 4 OXO IMIDAZO[1,2 A]INDENO[1,2 E]PYRAZIN 9 CARBOXYLIC ACID; AMPA RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; COMPLEX FORMATION; DERIVATIZATION; DRUG POTENCY; MEMBRANE DEPOLARIZATION; NEUROPROTECTION; RECEPTOR BINDING; SYNTHESIS;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; ANTICONVULSANTS; BRAIN; CELL MEMBRANE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; EXCITATORY AMINO ACID AGONISTS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MALE; MICE; MICE, INBRED DBA; OOCYTES; PROTEIN BINDING; PYRAZINES; RATS; RECEPTORS, AMPA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; XENOPUS;

EID: 0034684750     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00561-8     Document Type: Article

References (24)