Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: Results of two phase III clinical trials

Journal of Neurosurgery

Volumn 91, Issue 5, 1999, Pages 737-743

  Morris, Gabrielle F ^b   Bullock, Ross ^a   Marshall, Sharon Bowers ^b   Marmarou, Anthony ^b   Maas, Andrew ^b   Marshall, Lawrence F ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Clinical trial design; Excitatory amino acid; Glutamate receptor antagonist; N methyl D aspartate; Selfotel; Severe head injury

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG PENETRATION; DRUG RECEPTOR BINDING; FEMALE; HEAD INJURY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; TREATMENT FAILURE;

EID: 0033388098     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1999.91.5.0737     Document Type: Article

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