메뉴 건너뛰기




Volumn 30, Issue 3, 1999, Pages 508-513

Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke

Author keywords

Cerebral infarction; Neuroprotection; Stroke management; Stroke, acute

Indexed keywords

6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0032967750     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.3.508     Document Type: Article
Times cited : (76)

References (16)
  • 1
    • 0022620257 scopus 로고
    • Glutamate and the pathophysiology of hypoxic-ischemic brain damage
    • Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol. 1986;19:105-111.
    • (1986) Ann Neurol , vol.19 , pp. 105-111
    • Rothman, S.M.1    Olney, J.W.2
  • 2
    • 0024559799 scopus 로고
    • N-Methyl-D-aspartate antagonists: Ready for clinical trial in brain ischemia?
    • Albers GW, Goldberg MP, Choi DW. N-Methyl-D-aspartate antagonists: ready for clinical trial in brain ischemia? Ann Neurol. 1989;25:398-403.
    • (1989) Ann Neurol , vol.25 , pp. 398-403
    • Albers, G.W.1    Goldberg, M.P.2    Choi, D.W.3
  • 3
    • 0028870990 scopus 로고
    • Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke
    • Albers GW, Atkinson RP, Kelley RE, Rosenbaum DM, on behalf of the Dextrorphan Study Group. Safety, tolerability, and pharmacokinetics of the N-methyl-D-aspartate antagonist dextrorphan in patients with acute stroke. Stroke. 1995;26:254-258.
    • (1995) Stroke , vol.26 , pp. 254-258
    • Albers, G.W.1    Atkinson, R.P.2    Kelley, R.E.3    Rosenbaum, D.M.4
  • 4
    • 0029891443 scopus 로고    scopus 로고
    • Recently developed neuroprotective therapies for acute stroke: A qualitative systematic review of clinical trials
    • Dorman PJ, Counsell CE, Sandercrock PAG. Recently developed neuroprotective therapies for acute stroke: a qualitative systematic review of clinical trials. CNS Drugs. 1996;5:457-474.
    • (1996) CNS Drugs , vol.5 , pp. 457-474
    • Dorman, P.J.1    Counsell, C.E.2    Sandercrock, P.A.G.3
  • 5
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • Muir DW, Lees KR. Clinical experience with excitatory amino acid antagonist drugs. Stroke. 1995;26:503-513.
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, D.W.1    Lees, K.R.2
  • 6
    • 0024338054 scopus 로고
    • Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs
    • Olney JW, Labruyere J, Price MT. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science. 1989;244:1360-1362.
    • (1989) Science , vol.244 , pp. 1360-1362
    • Olney, J.W.1    Labruyere, J.2    Price, M.T.3
  • 7
    • 0343472092 scopus 로고    scopus 로고
    • Termination of acute stroke studies involving selfotel treatment: ASSIST Steering Committee
    • Davis SM, Albers GW, Diener HC, Lees KR, Norris J. Termination of acute stroke studies involving selfotel treatment: ASSIST Steering Committee. Lancet. 1997;349:32.
    • (1997) Lancet , vol.349 , pp. 32
    • Davis, S.M.1    Albers, G.W.2    Diener, H.C.3    Lees, K.R.4    Norris, J.5
  • 8
    • 0026630259 scopus 로고
    • Glycine antagonists: Regulation of the NMDA receptor-channel complex by the strychnine-insensitive glycine site
    • Carter AJ. Glycine antagonists: regulation of the NMDA receptor-channel complex by the strychnine-insensitive glycine site. Drugs Future. 1992; 17:595-613.
    • (1992) Drugs Future , vol.17 , pp. 595-613
    • Carter, A.J.1
  • 9
    • 0028962281 scopus 로고
    • Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures
    • Newell DW, Barth A, Malouf AT. Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures. Brain Res. 1995;675:38-44.
    • (1995) Brain Res , vol.675 , pp. 38-44
    • Newell, D.W.1    Barth, A.2    Malouf, A.T.3
  • 10
    • 26344459157 scopus 로고    scopus 로고
    • Glycine antagonists for treatment of ischemic brain injury in clinical pharmacology of cerebral ischemia
    • Ter Horst GJ, Korf J, eds. Totowa, NJ: Humana Press Inc
    • Yenari MA, Tong DC, Albers GW. Glycine antagonists for treatment of ischemic brain injury in clinical pharmacology of cerebral ischemia. In: Ter Horst GJ, Korf J, eds. Clinical Pharmacology of Cerebral Ischemia. Totowa, NJ: Humana Press Inc; 1996:127-151.
    • (1996) Clinical Pharmacology of Cerebral Ischemia , pp. 127-151
    • Yenari, M.A.1    Tong, D.C.2    Albers, G.W.3
  • 11
    • 0344080817 scopus 로고    scopus 로고
    • Phase II studies of the glycine antagonist, GV150526, in acute stroke (GAIN)
    • Abstract
    • The GAIN Investigators. Phase II studies of the glycine antagonist, GV150526, in acute stroke (GAIN). Stroke. 1998;29:304. Abstract.
    • (1998) Stroke , vol.29 , pp. 304
  • 12
    • 0028916586 scopus 로고
    • In vitro pharmacology of ACEA-1021 and ACEA-1031: Systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites
    • Woodward RM, Huettner JE, Guastella J, Keana FJW, Weber E. In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites. Mol Pharmacol. 1995;47:568-581.
    • (1995) Mol Pharmacol , vol.47 , pp. 568-581
    • Woodward, R.M.1    Huettner, J.E.2    Guastella, J.3    Keana, F.J.W.4    Weber, E.5
  • 13
    • 85038180933 scopus 로고
    • Focal ischemia after therapy with a glutamate antagonist-preserved tissue energy metabolism and reduction in infarct size
    • Abstract
    • Myseros J, Oetting GM, Bullock M, Corwin F, Fatouros P. Focal ischemia after therapy with a glutamate antagonist-preserved tissue energy metabolism and reduction in infarct size. J Cereb Blood Flow Metab. 1995;15:S367. Abstract.
    • (1995) J Cereb Blood Flow Metab , vol.15
    • Myseros, J.1    Oetting, G.M.2    Bullock, M.3    Corwin, F.4    Fatouros, P.5
  • 14
    • 0028834171 scopus 로고
    • In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists
    • Warner DS, Martin H, Ludwig P, McAllister A, Keana JFW, Weber E. In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. J Cereb Blood Flow Metab. 1995;15:188-196.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 188-196
    • Warner, D.S.1    Martin, H.2    Ludwig, P.3    McAllister, A.4    Keana, J.F.W.5    Weber, E.6
  • 15
    • 85038178994 scopus 로고    scopus 로고
    • Studies to investigate the minimum effective dose of licostinel (ACEA 1021) in a rat model of transient focal cerebral ischemia
    • Xue D, Miyazaki BK, Chen X, Daniell G, Woodward RM. Studies to investigate the minimum effective dose of licostinel (ACEA 1021) in a rat model of transient focal cerebral ischemia. Can J Neurol Sci. 1998; 25(suppl):S13.
    • (1998) Can J Neurol Sci , vol.25 , Issue.SUPPL.
    • Xue, D.1    Miyazaki, B.K.2    Chen, X.3    Daniell, G.4    Woodward, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.