메뉴 건너뛰기




Volumn 283, Issue 3, 1997, Pages 1285-1292

Ro 25-6981, a highly potent and selective blocker of N-methyl-D- aspartate receptors containing the NR2B subunit. Characterization in vitro

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; CALCIUM ION; DIZOCILPINE; GLUCOSE; GLUTAMIC ACID; IFENPRODIL; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OXYGEN; POTASSIUM ION; RECEPTOR SUBTYPE; SODIUM ION; UNCLASSIFIED DRUG; VERATRIDINE;

EID: 0031443289     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (434)

References (68)
  • 1
    • 0024335298 scopus 로고
    • Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurons
    • AKAIKE, N., KOSTYUK, P. G. AND OSIPCHUK, Y. Y.: Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurons. J. Physiol. 412: 181-195, 1989.
    • (1989) J. Physiol. , vol.412 , pp. 181-195
    • Akaike, N.1    Kostyuk, P.G.2    Osipchuk, Y.Y.3
  • 2
    • 0027174665 scopus 로고
    • Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones
    • Lond
    • BENVENISTE, M. AND MAYER, M. L.: Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones. J. Physiol. (Lond) 464: 131-163, 1993.
    • (1993) J. Physiol. , vol.464 , pp. 131-163
    • Benveniste, M.1    Mayer, M.L.2
  • 3
    • 0028360281 scopus 로고
    • The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltageoperated Ca2+ channels in rat cultured cortical neurons
    • BITON, B., GRANGER, P., CARREAU, A., DEPOORTERE, H., SCATTON, B. AND AVENET, P.: The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltageoperated Ca2+ channels in rat cultured cortical neurons. Eur. J. Pharmacol. 257: 297-301, 1994.
    • (1994) Eur. J. Pharmacol. , vol.257 , pp. 297-301
    • Biton, B.1    Granger, P.2    Carreau, A.3    Depoortere, H.4    Scatton, B.5    Avenet, P.6
  • 4
    • 0029934332 scopus 로고    scopus 로고
    • Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits
    • BLAHOS, J.2ND AND WENTHOLD, R. J.: Relationship between N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunits. J. Biol. Chem. 271: 15669-15674, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 15669-15674
    • Blahos II, J.1    Wenthold, R.J.2
  • 5
    • 0025142948 scopus 로고
    • Focal cerebral ischemia in the cat: Pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene
    • BULLOCK, R., GRAHAM, D. I., CHEN, M. H., LOWE, D. AND MCCULLOCH, J.: Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene. J. Cereb. Blood Flow Metab. 10: 668-674, 1990.
    • (1990) J. Cereb. Blood Flow Metab. , vol.10 , pp. 668-674
    • Bullock, R.1    Graham, D.I.2    Chen, M.H.3    Lowe, D.4    Mcculloch, J.5
  • 7
    • 0018873513 scopus 로고
    • Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes
    • CATTERALL, W. A.: Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Annu. Rev. Pharmacol. Toxicol. 20: 15-43, 1980.
    • (1980) Annu. Rev. Pharmacol. Toxicol. , vol.20 , pp. 15-43
    • Catterall, W.A.1
  • 8
    • 0026088184 scopus 로고
    • Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds
    • CHENARD, B. L., SHALABY, I. A., KOE, B. K., RONAU, R. T., BUTLER, T. W., PROCHNIAK, M. A., SCHMIDT, A. W. AND FOX, C. B.: Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds. J. Med. Chem. 34: 3085-3090, 1991.
    • (1991) J. Med. Chem. , vol.34 , pp. 3085-3090
    • Chenard, B.L.1    Shalaby, I.A.2    Koe, B.K.3    Ronau, R.T.4    Butler, T.W.5    Prochniak, M.A.6    Schmidt, A.W.7    Fox, C.B.8
  • 9
    • 0023870521 scopus 로고
    • Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
    • CHOI, D. W., KOH, J. Y. AND PETERS, S.: Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8: 185-196, 1988.
    • (1988) J. Neurosci. , vol.8 , pp. 185-196
    • Choi, D.W.1    Koh, J.Y.2    Peters, S.3
  • 10
    • 0028003653 scopus 로고
    • Blockade by ifenprodil of high voltage-activated Ca2 + channels in rat and mouse cultured hippocampal pyramidal neurones: Comparison with N- methyl-Daspartate receptor antagonist actions
    • CHURCH, J., FLETCHER, E. J., BAXTER, K. AND MACDONALD, J. F.: Blockade by ifenprodil of high voltage-activated Ca2 + channels in rat and mouse cultured hippocampal pyramidal neurones: comparison with N- methyl-Daspartate receptor antagonist actions. Br. J. Pharmacol. 113: 499-507, 1994.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 499-507
    • Church, J.1    Fletcher, E.J.2    Baxter, K.3    Macdonald, J.F.4
  • 11
    • 0027323130 scopus 로고
    • Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C
    • DURAND, G. M., BENNETT, M. V. AND ZUKIN, R. S.: Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 90: 6731-6735, 1993.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 6731-6735
    • Durand, G.M.1    Bennett, M.V.2    Zukin, R.S.3
  • 12
    • 0028295715 scopus 로고
    • NMDA-r receptor channel diversity in the developing cerebellum
    • FARRANT, M., FELDMEYER, D., TAKAHASHI, T. AND CULL CANDY, S. G.: NMDA-r receptor channel diversity in the developing cerebellum. Nature 368: 335-339, 1994.
    • (1994) Nature , vol.368 , pp. 335-339
    • Farrant, M.1    Feldmeyer, D.2    Takahashi, T.3    Cull Candy, S.G.4
  • 13
    • 0345460317 scopus 로고    scopus 로고
    • The neuroprotective activity of Ro 25-6981, a NMDA receptor NR2B subtype selective blocker
    • FISCHER, G., BOURSON, A., KEMP, J. A. AND LOREZ, H. P.: The neuroprotective activity of Ro 25-6981, a NMDA receptor NR2B subtype selective blocker. Soc. Neurosci. Abstr. 22: part 3, 1760, 1996.
    • (1996) Soc. Neurosci. Abstr. , vol.22 , Issue.3 PART , pp. 1760
    • Fischer, G.1    Bourson, A.2    Kemp, J.A.3    Lorez, H.P.4
  • 14
    • 0029871365 scopus 로고    scopus 로고
    • Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor
    • GALLAGHER, M. J., HUANG, H., PRITCHETT, D. B. AND LYNCH, D. R.: Interactions between ifenprodil and the NR2B subunit of the N-methyl-D-aspartate receptor. J. Biol. Chem. 271: 9603-9611, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 9603-9611
    • Gallagher, M.J.1    Huang, H.2    Pritchett, D.B.3    Lynch, D.R.4
  • 15
    • 0028852625 scopus 로고
    • The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischaemia
    • GILL, R., HARGREAVES, R. J. AND KEMP, J. A.: The neuroprotective effect of the glycine site antagonist 3R-(+)-cis-4-methyl-HA966 (L-687,414) in a rat model of focal ischaemia. J. Cereb. Blood Flow Metab. 15: 197-204, 1995.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 197-204
    • Gill, R.1    Hargreaves, R.J.2    Kemp, J.A.3
  • 16
    • 0027328680 scopus 로고
    • Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury
    • GOLDBERG, M. P. AND CHOI, D. W.: Combined oxygen and glucose deprivation in cortical cell culture: Calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13: 3510-3524, 1993.
    • (1993) J. Neurosci. , vol.13 , pp. 3510-3524
    • Goldberg, M.P.1    Choi, D.W.2
  • 18
    • 0026656546 scopus 로고
    • The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies
    • GRAHAM, D., DARLES, G. AND LANGER, S. Z.: The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies. Eur. J. Pharmacol. 226: 373-376, 1992.
    • (1992) Eur. J. Pharmacol. , vol.226 , pp. 373-376
    • Graham, D.1    Darles, G.2    Langer, S.Z.3
  • 19
    • 0029664442 scopus 로고    scopus 로고
    • Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites
    • GRIMWOOD, S., GILBERT, E., RAGAN, C. I. AND HUTSON, P. H.: Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites. J. Neurochem. 66: 2589-2595, 1996a.
    • (1996) J. Neurochem. , vol.66 , pp. 2589-2595
    • Grimwood, S.1    Gilbert, E.2    Ragan, C.I.3    Hutson, P.H.4
  • 21
    • 0021895138 scopus 로고
    • A new generation of Ca2+ indicators with greatly improved fluorescence properties
    • GRYNKIEWICZ, G., POENIE, M. AND TSIEN, R. Y.: A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
    • (1985) J. Biol. Chem. , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 23
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA response in cultured mouse brain neurons
    • JOHNSON, J. W. AND ASCHER, P.: Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325: 529-531, 1987.
    • (1987) Nature , vol.325 , pp. 529-531
    • Johnson, J.W.1    Ascher, P.2
  • 24
    • 15644369499 scopus 로고    scopus 로고
    • Ifenprodil and Ro 25-6981 are activity-dependent antagonists of NMDA NR2B subunit containing receptors
    • KEMP, J. A., TRUBE, G. AND KEW, J. N. C.: Ifenprodil and Ro 25-6981 are activity-dependent antagonists of NMDA NR2B subunit containing receptors. Soc. Neurosci. Abstr. 22: part 3, 1760, 1996.
    • (1996) Soc. Neurosci. Abstr. , vol.22 , Issue.3 PART , pp. 1760
    • Kemp, J.A.1    Trube, G.2    Kew, J.N.C.3
  • 25
    • 0030017358 scopus 로고    scopus 로고
    • Characterization of glutamate binding sites in receptors assembled from transfected NMDA receptor subunits
    • KENDRICK, S. J., LYNCH, D. R. AND PRITCHETT, D. B.: Characterization of glutamate binding sites in receptors assembled from transfected NMDA receptor subunits. J. Neurochem. 67: 608-616, 1996.
    • (1996) J. Neurochem. , vol.67 , pp. 608-616
    • Kendrick, S.J.1    Lynch, D.R.2    Pritchett, D.B.3
  • 26
    • 0030450983 scopus 로고    scopus 로고
    • A novel mechanism of the activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones
    • KEW, J. N. C., TRUBE, G. AND KEMP, J. A.: A novel mechanism of the activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones. J. Physiol. 497: 761-772, 1996.
    • (1996) J. Physiol. , vol.497 , pp. 761-772
    • Kew, J.N.C.1    Trube, G.2    Kemp, J.A.3
  • 27
    • 0023221068 scopus 로고
    • Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
    • KOH, J. AND CHOI, D. W.: Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 20: 83-90, 1987.
    • (1987) J. Neurosci. Methods , vol.20 , pp. 83-90
    • Koh, J.1    Choi, D.W.2
  • 29
    • 0028226884 scopus 로고
    • Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA
    • LAURIE, D. J. AND SEEBURG, P. H.: Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J. Neurosci. 14: 3180-3194, 1994.
    • (1994) J. Neurosci. , vol.14 , pp. 3180-3194
    • Laurie, D.J.1    Seeburg, P.H.2
  • 30
    • 0031032658 scopus 로고    scopus 로고
    • The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B)
    • LUO, J., WANG, Y., YASUDA, R. P., DUNAH, A. W. AND WOLFE, B. B.: The majority of N-methyl-D-aspartate receptor complexes in adult rat cerebral cortex contain at least three different subunits (NR1/NR2A/NR2B). Mol. Pharmacol. 51: 79-86, 1997.
    • (1997) Mol. Pharmacol. , vol.51 , pp. 79-86
    • Luo, J.1    Wang, Y.2    Yasuda, R.P.3    Dunah, A.W.4    Wolfe, B.B.5
  • 31
    • 0028965922 scopus 로고
    • Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: Differences with receptors formed from NR 1a and 2A
    • LYNCH, D. R., LAWRENCE, J. J., LENZ, S., ANEGAWA, N. J., DICHTER, M. AND PRITCHETT, D. B.: Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: Differences with receptors formed from NR 1a and 2A. J. Neurochem. 64: 1462-1468, 1995.
    • (1995) J. Neurochem. , vol.64 , pp. 1462-1468
    • Lynch, D.R.1    Lawrence, J.J.2    Lenz, S.3    Anegawa, N.J.4    Dichter, M.5    Pritchett, D.B.6
  • 32
    • 0025328092 scopus 로고
    • GABA-A receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands
    • MALHERBE, P., DRAGHUN, A., MULTHAUP, G., BEYREUTHER, K. AND MOHLER, H.: GABA-A receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligands. Mol. Brain Res. 8:199-208, 1990.
    • (1990) Mol. Brain Res. , vol.8 , pp. 199-208
    • Malherbe, P.1    Draghun, A.2    Multhaup, G.3    Beyreuther, K.4    Mohler, H.5
  • 34
    • 0022911410 scopus 로고
    • Patch clamp measurements on Xenopus laeuis oocytes: Currents through endogenous channels and implanted acetylcholine receptor and sodium channels
    • METHFESSEL, C., WITZEMANN, V., TAKAHASHI, T., MISHINA, M., NUMA, S. AND SAKMANN, B.: Patch clamp measurements on Xenopus laeuis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflügers Arch. 407: 577-588, 1986.
    • (1986) Pflügers Arch. , vol.407 , pp. 577-588
    • Methfessel, C.1    Witzemann, V.2    Takahashi, T.3    Mishina, M.4    Numa, S.5    Sakmann, B.6
  • 35
    • 0024853570 scopus 로고
    • Fluorescent indicators for cytosolic sodium
    • MINTA, A. AND TSIEN, R. Y.: Fluorescent indicators for cytosolic sodium. J. Biol. Chem. 264: 19449-19457, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 19449-19457
    • Minta, A.1    Tsien, R.Y.2
  • 36
    • 0028198969 scopus 로고
    • Vulnerability to excitotoxic stimuli of cultured rat hippocampal neurons containing the calcium-binding proteins calretinin and calbindin D28K
    • MÖCKEL, V. AND FISCHER, G.: Vulnerability to excitotoxic stimuli of cultured rat hippocampal neurons containing the calcium-binding proteins calretinin and calbindin D28K. Brain Res. 648: 109-120, 1994.
    • (1994) Brain Res. , vol.648 , pp. 109-120
    • Möckel, V.1    Fischer, G.2
  • 37
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • MONYER, H., BURNASHEV, N., LAURIE, D. J., SAKWANN, B. AND SEEBURG, P. H.: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540, 1994.
    • (1994) Neuron , vol.12 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakwann, B.4    Seeburg, P.H.5
  • 38
    • 0028810883 scopus 로고
    • Structure and function of the NMDA receptor channel
    • MORI, H. AND MISHINA, M.: Structure and function of the NMDA receptor channel. Neuropharmacology 34: 1219-1237, 1995.
    • (1995) Neuropharmacology , vol.34 , pp. 1219-1237
    • Mori, H.1    Mishina, M.2
  • 39
    • 0028897733 scopus 로고
    • Clinical experience with excitatory amino acid antagonist drugs
    • MUIR, K. W. AND LEES, K. R.: Clinical experience with excitatory amino acid antagonist drugs. Stroke 26: 503-513, 1995.
    • (1995) Stroke , vol.26 , pp. 503-513
    • Muir, K.W.1    Lees, K.R.2
  • 40
    • 0026419339 scopus 로고
    • Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses
    • MULLER, W. AND CONNOR, J. A.: Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses. Nature 354: 73-76, 1991.
    • (1991) Nature , vol.354 , pp. 73-76
    • Muller, W.1    Connor, J.A.2
  • 41
    • 0026779363 scopus 로고
    • Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors
    • NAKANISHI, N., AXEL, R. AND SHNEIDER, N. A.: Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. U.S.A. 89: 8552-8556, 1992.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 8552-8556
    • Nakanishi, N.1    Axel, R.2    Shneider, N.A.3
  • 42
    • 15644380359 scopus 로고
    • Effects of some NMDA receptor channel antagonists on voltage-dependent Ca2+ channels in cultured cortical neurons
    • ed. by J. Krieglstein and H. Oberpichler-Schwenk, Wissenschafftliche Verlagsgesellschaft mbH, Stuttgart, Germany
    • NETZER, R., GRAF, V., PFLIMLIN, P. AND TRUBE, G.: Effects of some NMDA receptor channel antagonists on voltage-dependent Ca2+ channels in cultured cortical neurons. In Pharmacology of Cerebral Ischemia, ed. by J. Krieglstein and H. Oberpichler-Schwenk, pp.129-137, Wissenschafftliche Verlagsgesellschaft mbH, Stuttgart, Germany, 1992.
    • (1992) Pharmacology of Cerebral Ischemia , pp. 129-137
    • Netzer, R.1    Graf, V.2    Pflimlin, P.3    Trube, G.4
  • 43
    • 0023788688 scopus 로고
    • The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat
    • PARK, C. K., NEHLS, D. G., GRAHAM, D. I., TEASDALE, G. M. AND MCCULLOCH, J.: The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat. Ann. Neurol. 24: 543-551, 1988.
    • (1988) Ann. Neurol. , vol.24 , pp. 543-551
    • Park, C.K.1    Nehls, D.G.2    Graham, D.I.3    Teasdale, G.M.4    Mcculloch, J.5
  • 44
    • 0025758738 scopus 로고
    • Ca++ and Na+ channels involved in neuronal cell death. Protection by flunarizine
    • PAUWELS, P. J., LEYSEN, J. E. AND JANSSEN, P. A.: Ca++ and Na+ channels involved in neuronal cell death. Protection by flunarizine. Life Sci. 48: 1881-1893, 1991.
    • (1991) Life Sci. , vol.48 , pp. 1881-1893
    • Pauwels, P.J.1    Leysen, J.E.2    Janssen, P.A.3
  • 45
    • 0029670633 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies
    • PORTERA CAILLIAU, C., PRICE, D. L. AND MARTIN, L. J.: N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies. J. Neurochem. 66: 692-700, 1996.
    • (1996) J. Neurochem. , vol.66 , pp. 692-700
    • Portera Cailliau, C.1    Price, D.L.2    Martin, L.J.3
  • 46
    • 0027939614 scopus 로고
    • Subtypes of NMDA receptor in neurones cultured from rat brain
    • PRIESTLEY, T., OCHU, E. AND KEMP, J. A.: Subtypes of NMDA receptor in neurones cultured from rat brain. Neuroreport 5: 1763-1765, 1994.
    • (1994) Neuroreport , vol.5 , pp. 1763-1765
    • Priestley, T.1    Ochu, E.2    Kemp, J.A.3
  • 47
    • 0028823737 scopus 로고
    • Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells
    • PRIESTLEY, T., LAUGHTON, P., MYERS, J., LE BOURDELLES, B., KERBY, J. AND WHITING, P. J.: Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Mol. Pharmacol. 48: 841-848, 1995.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 841-848
    • Priestley, T.1    Laughton, P.2    Myers, J.3    Le Bourdelles, B.4    Kerby, J.5    Whiting, P.J.6
  • 48
    • 0023820777 scopus 로고
    • 3H)MK-801 binding to the N-methyl-D- aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines
    • 3H)MK-801 binding to the N-methyl-D- aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J. Neurochem. 51: 830-836, 1988.
    • (1988) J. Neurochem. , vol.51 , pp. 830-836
    • Ransom, R.W.1    Stec, N.L.2
  • 49
    • 0024316832 scopus 로고
    • Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: Interaction with polyamines
    • REYNOLDS, I. J. AND MILLER, R. J.: Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol. Pharmacol. 36: 758-765, 1989.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 758-765
    • Reynolds, I.J.1    Miller, R.J.2
  • 50
    • 0027310151 scopus 로고
    • Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: An in vivo magnetic resonance imaging study
    • SAUER, D., ALLEGRINI, P. R., COSENTI, A., PATAKI, A., AMACKER, H. AND FAGG, G. E.: Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: an in vivo magnetic resonance imaging study. J. Cereb. Blood Flow Metab. 13: 595-602, 1993.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 595-602
    • Sauer, D.1    Allegrini, P.R.2    Cosenti, A.3    Pataki, A.4    Amacker, H.5    Fagg, G.E.6
  • 51
    • 0026563871 scopus 로고
    • Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture
    • SHALABY, I. A., CHENARD, B. L., PROCHNIAK, M. A. AND BUTLER, T. W.: Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. J. Pharmacol. Exp. Ther. 260: 925-932, 1992.
    • (1992) J. Pharmacol. Exp. Ther. , vol.260 , pp. 925-932
    • Shalaby, I.A.1    Chenard, B.L.2    Prochniak, M.A.3    Butler, T.W.4
  • 52
    • 0028219211 scopus 로고
    • Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
    • SHENG, M., CUMMINGS, J., ROLDAN, L. A., JAN, Y. N. AND JAN, L. Y.: Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368: 144-147, 1994.
    • (1994) Nature , vol.368 , pp. 144-147
    • Sheng, M.1    Cummings, J.2    Roldan, L.A.3    Jan, Y.N.4    Jan, L.Y.5
  • 53
    • 0028246842 scopus 로고
    • Protein kinase C transiently activated heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites
    • SIGEL, E., BAUR, R. AND MALHERBE, P.: Protein kinase C transiently activated heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites. J. Biol. Chem. 269: 8204-8208, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8204-8208
    • Sigel, E.1    Baur, R.2    Malherbe, P.3
  • 54
    • 0027496763 scopus 로고
    • Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons
    • TAMURA, Y., SATO, Y., YOKOTA, T., AKAIKE, A., SASA, M. AND TAKAORI, S.: Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons. J. Pharmacol. Exp. Ther. 265: 1017-1025, 1993.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 1017-1025
    • Tamura, Y.1    Sato, Y.2    Yokota, T.3    Akaike, A.4    Sasa, M.5    Takaori, S.6
  • 55
    • 0029021010 scopus 로고
    • Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
    • TRAYNELIS, S. F., HARTLEY, M. AND HEINEMANN, S. F.: Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science 268: 873-876, 1995.
    • (1995) Science , vol.268 , pp. 873-876
    • Traynelis, S.F.1    Hartley, M.2    Heinemann, S.F.3
  • 56
    • 0342725650 scopus 로고    scopus 로고
    • The selectivity of Ro 25-6981 for NMDA receptor subtypes expressed in Xenopus oocytes
    • TRUBE, G., EHRHARD, P., MALHERBE, P. AND HUBER, G.: The selectivity of Ro 25-6981 for NMDA receptor subtypes expressed in Xenopus oocytes. Soc. Neurosci. Abstr. 22: part 3, 1760, 1996.
    • (1996) Soc. Neurosci. Abstr. , vol.22 , Issue.3 PART , pp. 1760
    • Trube, G.1    Ehrhard, P.2    Malherbe, P.3    Huber, G.4
  • 57
    • 0028834171 scopus 로고
    • In vivo models of cerebral ischemia: Effects of parenterally administered NMDA receptor glycine site antagonists
    • WARNER, D. S., MARTIN, H., LUDWIG, P., MCALLISTER, A., KEANA, J. F. AND WEBER, E.: In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists. J. Cereb. Blood Flow Metab. 15: 188-196, 1995.
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 188-196
    • Warner, D.S.1    Martin, H.2    Ludwig, P.3    Mcallister, A.4    Keana, J.F.5    Weber, E.6
  • 58
    • 0029552595 scopus 로고
    • Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain
    • WENZEL, A., SCHEURER, L., KUNZI, R., FRITSCHY, J. M., MOHLER, H. AND BENKE, D.: Distribution of NMDA receptor subunit proteins NR2A, 2B, 2C and 2D in rat brain. NeuroReport 7: 45-48, 1995.
    • (1995) NeuroReport , vol.7 , pp. 45-48
    • Wenzel, A.1    Scheurer, L.2    Kunzi, R.3    Fritschy, J.M.4    Mohler, H.5    Benke, D.6
  • 59
    • 0031012513 scopus 로고    scopus 로고
    • NMDA receptor herterogeneity during postnatal development of the rat brain: Differential expression of the NR2A, NR2B, and NR2C subunit proteins
    • WENZEL, A., FRITSCHY, J. M., MOHLER, H. AND BENKE, D.: NMDA receptor herterogeneity during postnatal development of the rat brain: Differential expression of the NR2A, NR2B, and NR2C subunit proteins. J. Neurochem. 68: 469-478, 1997.
    • (1997) J. Neurochem. , vol.68 , pp. 469-478
    • Wenzel, A.1    Fritschy, J.M.2    Mohler, H.3    Benke, D.4
  • 60
    • 0029924437 scopus 로고    scopus 로고
    • Antagonist pharmacology of kainate- and alpha-amino-3-hydroxy-5-α-methyl-4-isoxazolepropionic acid-preferring receptors
    • WILDING, T. J. AND HUETTNER, J. E.: Antagonist pharmacology of kainate- and alpha-amino-3-hydroxy-5-α-methyl-4-isoxazolepropionic acid-preferring receptors. Mol. Pharmacol. 49: 540-546, 1996.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 540-546
    • Wilding, T.J.1    Huettner, J.E.2
  • 61
    • 0027525324 scopus 로고
    • Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: Selectivity and mechanisms at recombinant heteromeric receptors
    • WILLIAMS, K.: Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44: 851-859, 1993.
    • (1993) Mol. Pharmacol. , vol.44 , pp. 851-859
    • Williams, K.1
  • 62
    • 0028821024 scopus 로고
    • Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) subunit
    • WILLIAMS, K.: Pharmacological properties of recombinant N-methyl-D-aspartate (NMDA) receptors containing the epsilon 4 (NR2D) subunit. Neurosci. Lett. 184: 181-184, 1995.
    • (1995) Neurosci. Lett. , vol.184 , pp. 181-184
    • Williams, K.1
  • 63
    • 0027405347 scopus 로고
    • Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
    • WILLIAMS, K., RUSSELL, S. L., SHEN, Y. M. AND MOLINOFF, P. B.: Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10: 267-278, 1993.
    • (1993) Neuron , vol.10 , pp. 267-278
    • Williams, K.1    Russell, S.L.2    Shen, Y.M.3    Molinoff, P.B.4
  • 64
    • 0028340993 scopus 로고
    • Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits
    • WILLIAMS, K., ZAPPIA, A. M., PRITCHETT, D. B., SHEN, Y. M. AND MOLINOFF, P. B.: Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. Mol. Pharmacol. 45: 803-809, 1994.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 803-809
    • Williams, K.1    Zappia, A.M.2    Pritchett, D.B.3    Shen, Y.M.4    Molinoff, P.B.5
  • 66
    • 0023818680 scopus 로고
    • 3H)MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes
    • 3H)MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes. J. Neurochem. 50: 274-281, 1988.
    • (1988) J. Neurochem. , vol.50 , pp. 274-281
    • Wong, E.H.1    Knight, A.R.2    Woodruff, G.N.3
  • 67
    • 0028362985 scopus 로고
    • Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons
    • ZHONG, J., RUSSELL, S. L., PRITCHETT, D. B., MOLINOFF, P. B. AND WILLIAMS, K.: Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol. Pharmacol. 45: 846-853, 1994.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 846-853
    • Zhong, J.1    Russell, S.L.2    Pritchett, D.B.3    Molinoff, P.B.4    Williams, K.5
  • 68
    • 0028873973 scopus 로고
    • Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain
    • ZHONG, J., CARROZZA, D. P., WILLIAMS, K., PRITCHETT, D. B. AND MOLINOFF, P. B.: Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J. Neurochem. 64: 531-539, 1995.
    • (1995) J. Neurochem. , vol.64 , pp. 531-539
    • Zhong, J.1    Carrozza, D.P.2    Williams, K.3    Pritchett, D.B.4    Molinoff, P.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.