(S)-4C3HPG reduces infarct size after focal cerebral ischemia

Neuropharmacology

Volumn 37, Issue 12, 1998, Pages 1649-1652

  Rauca, C ^a   Henrich Noack, P ^b   Schafer K ^a   Hollt V ^a   Reymann, K G ^b  

^a UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^b LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

Author keywords

(S) 4C3HPG; Focal cerebral ischemia; Intracerebroventricular injection; Metabotropic glutamate receptors; Neuroprotection; Stroke

Indexed keywords

4 CARBOXY 3 HYDROXYPHENYLGLYCINE; METABOTROPIC RECEPTOR; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG MECHANISM; HEART INFARCTION SIZE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT SURVEY; STROKE;

EID: 0032403093     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00146-4     Document Type: Article

References (15)

1. Bond A., Lodge D. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo. Neuropharmacology. 34:1995;1015-1023.
2. Bruno V., Sureda F.X., Storto M., Casabona G., Caruso A., Knöpfel T., Kuhn R., Nicoletti F. The neuroprotective activity of group-II metabotropic glutamate receptors requires new protein synthesis and involves a glial-neuronal signaling. J. Neurosci. 17:1997;1891-1897.
3. Buisson A., Choi D.W. The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death. Neuropharmacology. 34:1995;1081-1087.
4. Conn P.J., Pin J.-P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37:1997;205-237.
5. Dalby O.N., Thomsen C. Modulation of seizure activity in mice by metabotropic glutamate receptor ligands. J. Pharmacol. Exp. Ther. 276:1996;516-522.
6. Henrich-Noack P., Reymann K.G. Activation of metabotropic glutamate receptors enhances neuronal damage in the CA1 region of the hippocampus after transient global ischemia. Naunyn-Schmiedebergs Arch. Pharmacol. 355(Suppl.):1997;92.
7. Henrich-Noack P., Hatton C.D., Reymann K.G. The mGlu receptor ligand (S)-4C3HPG protects neurones after global ischaemia in gerbils. Neuroreport. 9:1998;985-988.
8. Knöpfel T., Kuhn R., Allgeier H. Metabotropic glutamate receptors: novel targets for drug development. J. Med. Chem. 38:1995;1417-1426.
9. Libri V., Constanti A., Zibetti M., Postlethwaite M. Metabotropic glutamate receptor subtypes mediating slow inward tail current (IADP) induction and inhibition of synaptic transmission in olfactory cortical neurones. Br. J. Pharmacol. 120:1997;1083-1095.
10. Manahan-Vaughan D., Reymann K.G. Group 1 metabotropic glutamate receptors contribute to slow-onset potentiation in the rat CA1 region in vivo. Neuropharmacology. 36:1997;1533-1538.
11. Manzoni O.J., Castillo P.E., Nicoll R.A. Pharmacology of metabotropic glutamate receptors at the mossy fiber synapses of the guinea pig hippocampus. Neuropharmacology. 34:1995;965-971.
12. Opitz T., Richter P., Carter A.J., Kozikowski A.P., Shinozaki H., Reymann K.G. Metabotropic glutamate receptor subtypes differentially influence neuronal recovery from in vitro hypoxia/hypoglycemia in rat hippocampal slices. Neuroscience. 68:1995;989-1001.
13. Orlando L.R., Standaert D.G., Penney J.B. Jr., Young A.B. Metabotropic receptors in exitotoxicity: (S)-4-carboxy-3-hydroxyphenylglycine ((S)-4C3HPG) protects against rat striatal quinolinic acid lesions. Neurosci. Lett. 202:1995;109-112.
14. Small D.L., Monette R., Chakravarthy B., Durkin J., Barba G., Mealing G., Morley P., Buchan A.M. Mechanisms of 1S,3R-ACPD-induced neuroprotection in rat hippocampal slices subjected to oxygen and glucose deprivation. Neuropharmacology. 35:1996;1037-1048.
15. Tamura A., Graham D.I., Mc Culloch J., Teasdale G.M. Focal cerebral ischemia in the rat. I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1:1981;53-60.