Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines

Journal of Medicinal Chemistry

Volumn 43, Issue 18, 2000, Pages 3408-3419

  Wright, J L ^a   Gregory, T F ^a   Kesten, S R ^a   Boxer, P A ^a   Serpa, K A ^a   Meltzer, L T ^a   Wise, L D ^a   Espitia, S A ^b   Konkoy, C S ^b   Whittemore, E R ^b   Woodward, R M ^b  

^a PFIZER INC   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 (4 BENZYLPIPERIDIN 1 YL)PROP 1 YNYL]PHENOL; 4 [4 (4 BENYZLPIPERIDIN 1 YL)BUT 1 YNYL]PHENOL; 4 PHOSPHONOMETHYLPIPECOLIC ACID; 5 [3 (4 BENZYLPIPERIDIN 1 YL)PROP 1 YNYL] 1,3 DIHYDROBENZOIMIDAZOL 2 ONE; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; ACETYLENE DERIVATIVE; ALKYNE DERIVATIVE; ALPHA 1 ADRENERGIC RECEPTOR; AMINE; BENZIMIDAZOLE DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; BENZYL DERIVATIVE; DIZOCILPINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; HETEROCYCLIC COMPOUND; HYDROXYL GROUP; IFENPRODIL; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; ISATIN DERIVATIVE; LEVODOPA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OXIDOPAMINE; PHENOL DERIVATIVE; PIPERIDINE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FIRST PASS EFFECT; HALLUCINATION; HUMAN; MALE; NONHUMAN; PARKINSON DISEASE; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ANIMALS; ANTIPARKINSON AGENTS; BENZIMIDAZOLES; CEREBRAL CORTEX; CORPUS STRIATUM; EXCITATORY AMINO ACID ANTAGONISTS; MALE; OOCYTES; PATCH-CLAMP TECHNIQUES; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSFECTION; XENOPUS LAEVIS;

EID: 0034618553     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000023o     Document Type: Article

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