SPD 502: A water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 289, Issue 3, 1999, Pages 1492-1501

  Nielsen, Elsebet Ø ^a   Varming, Thomas ^a   Mathiesen, Claus ^a   Jensen, Leif H ^a   Møller, Arne ^a   Gouliaev, Alex H ^a   Wätjen, Frank ^a   Drejer, Jørgen ^a  

^a NEUROSEARCH A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 (4 DIMETHYLSULFAMOYLPHENYL) 6,7,8,9 TETRAHYDRO 8 METHYL 2 OXO 1H PYRROLO[3,2 H]ISOQUINOLIN 3 YLIMINOXY] 4 HYDROXYBUTYRIC ACID; 4 PHOSPHONOMETHYLPIPECOLIC ACID; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLYCINE RECEPTOR; KAINIC ACID RECEPTOR; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN CELL; BRAIN ISCHEMIA; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ELECTROPHYSIOLOGY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SEIZURE THRESHOLD;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL MEMBRANE; CELLS, CULTURED; CEREBRAL CORTEX; ELECTROSHOCK; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLYCINE; ISOQUINOLINES; KAINIC ACID; KINETICS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; PIPECOLIC ACIDS; PYRROLES; QUINOXALINES; RATS; RATS, WISTAR; RECEPTORS, AMPA; SEIZURES; STEREOISOMERISM; TETRAHYDROISOQUINOLINES;

EID: 0033022769     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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