Subtype-selective N-methyl-D-aspartate receptor antagonists: Benzimidazalone and hydantoin as phenol replacements

Journal of Medicinal Chemistry

Volumn 43, Issue 9, 2000, Pages 1892-1897

  Schelkun, R M ^a   Yuen, P W ^a   Serpa, K ^a   Meltzer, L T ^a   Wise, L D ^a   Whittemore, E R ^b   Woodward, R M ^b  

^a PFIZER INC   (United States)

^b Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 (4 BENZYLPIPERIDIN 1 YL)PROPYL] 1,3 DIHYDROBENZIMIDAZOL 2 ONE; BENZIMIDAZALONE; BENZIMIDAZOLE DERIVATIVE; HYDANTOIN; IFENPRODIL; LEVODOPA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENOL; TRAXOPRODIL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN PROTECTION; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; MALE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; RAT; XENOPUS;

ANIMALS; BENZIMIDAZOLES; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; HYDANTOINS; HYDROGEN BONDING; MALE; NEUROPROTECTIVE AGENTS; OOCYTES; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SYMPATHOLYTICS; XENOPUS;

EID: 0034026350     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990537r     Document Type: Article

References (22)