-
1
-
-
84982270082
-
Towards precision medicine
-
COI: 1:CAS:528:DC%2BC28XhtlChs77M, PID: 27528417
-
Ashley, E. A. Towards precision medicine. Nat. Rev. Genet. 17, 507–522 (2016)
-
(2016)
Nat. Rev. Genet.
, vol.17
, pp. 507-522
-
-
Ashley, E.A.1
-
2
-
-
85040461653
-
Precision oncology in the age of integrative genomics
-
COI: 1:CAS:528:DC%2BC1cXmtlSlug%3D%3D, PID: 29319699
-
Kumar-Sinha, C. & Chinnaiyan, A. M. Precision oncology in the age of integrative genomics. Nat. Biotechnol. 36, 46–60 (2018)
-
(2018)
Nat. Biotechnol.
, vol.36
, pp. 46-60
-
-
Kumar-Sinha, C.1
Chinnaiyan, A.M.2
-
3
-
-
85042441344
-
The evidence framework for precision cancer medicine
-
PID: 29255239
-
Moscow, J. A., Fojo, T. & Schilsky, R. L. The evidence framework for precision cancer medicine. Nat. Rev. Clin. Oncol. 15, 183–192 (2018)
-
(2018)
Nat. Rev. Clin. Oncol.
, vol.15
, pp. 183-192
-
-
Moscow, J.A.1
Fojo, T.2
Schilsky, R.L.3
-
4
-
-
85020279899
-
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
-
COI: 1:CAS:528:DC%2BC2sXntFKitLo%3D, PID: 28481359
-
Zehir, A. et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat. Med. 23, 703–713 (2017)
-
(2017)
Nat. Med.
, vol.23
, pp. 703-713
-
-
Zehir, A.1
-
5
-
-
84884994218
-
The Cancer Genome Atlas Pan-Cancer analysis project
-
Cancer Genome Atlas Research Network. The Cancer Genome Atlas Pan-Cancer analysis project. Nat. Genet. 45, 1113–1120 (2013)
-
(2013)
Nat. Genet.
, vol.45
, pp. 1113-1120
-
-
-
6
-
-
85029555696
-
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers
-
COI: 1:CAS:528:DC%2BC2sXhsVers7vF, PID: 28874546
-
Cohen, J. D. et al. Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proc. Natl Acad. Sci. USA 114, 10202–10207 (2017)
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. 10202-10207
-
-
Cohen, J.D.1
-
7
-
-
85040865768
-
Detection and localization of surgically resectable cancers with a multi-analyte blood test
-
COI: 1:CAS:528:DC%2BC1cXjtVWgtrs%3D, PID: 29348365, This paper shows that a blood test can detect eight common cancer types through assessment of the levels of circulating proteins and mutations cell-free DNA with a median diagtic sensitivity of 70%
-
Cohen, J. D. et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 359, 926–930 (2018). This paper shows that a blood test can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA with a median diagnostic sensitivity of 70%
-
(2018)
Science
, vol.359
, pp. 926-930
-
-
Cohen, J.D.1
-
8
-
-
85027045679
-
Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal cancer
-
COI: 1:CAS:528:DC%2BC2sXhtlyksrbI, PID: 28792880, This prospective study investigates the use of EBV DNA plasma samples to screen for early nasopharyngeal carcinoma asymptomatic persons and achieves a sensitivity and specificity of 97.1% and 98.6%, respectively
-
Chan, K. C. A. et al. Analysis of plasma Epstein-Barr virus DNA to screen for nasopharyngeal cancer. N. Engl. J. Med. 377, 513–522 (2017). This prospective study investigates the use of EBV DNA in plasma samples to screen for early nasopharyngeal carcinoma in asymptomatic persons and achieves a sensitivity and specificity of 97.1% and 98.6%, respectively
-
(2017)
N. Engl. J. Med.
, vol.377
, pp. 513-522
-
-
Chan, K.C.A.1
-
9
-
-
77956268304
-
Circulating tumour cells in cancer patients: challenges and perspectives
-
PID: 20667783
-
Pantel, K. & Alix-Panabieres, C. Circulating tumour cells in cancer patients: challenges and perspectives. Trends Mol. Med. 16, 398–406 (2010)
-
(2010)
Trends Mol. Med.
, vol.16
, pp. 398-406
-
-
Pantel, K.1
Alix-Panabieres, C.2
-
10
-
-
85014091144
-
Integrating liquid biopsies into the management of cancer
-
COI: 1:CAS:528:DC%2BC2sXkvVSns7g%3D, PID: 28252003
-
Siravegna, G., Marsoni, S., Siena, S. & Bardelli, A. Integrating liquid biopsies into the management of cancer. Nat. Rev. Clin. Oncol. 14, 531–548 (2017)
-
(2017)
Nat. Rev. Clin. Oncol.
, vol.14
, pp. 531-548
-
-
Siravegna, G.1
Marsoni, S.2
Siena, S.3
Bardelli, A.4
-
11
-
-
85013854018
-
Liquid biopsies come of age: towards implementation of circulating tumour DNA
-
COI: 1:CAS:528:DC%2BC2sXkt1Ont7s%3D, PID: 28233803
-
Wan, J. C. M. et al. Liquid biopsies come of age: towards implementation of circulating tumour DNA. Nat. Rev. Cancer 17, 223–238 (2017)
-
(2017)
Nat. Rev. Cancer
, vol.17
, pp. 223-238
-
-
Wan, J.C.M.1
-
12
-
-
84920508228
-
Circulating tumor DNA as a liquid biopsy for cancer
-
COI: 1:CAS:528:DC%2BC2MXptVKkuw%3D%3D, PID: 25388429
-
Heitzer, E., Ulz, P. & Geigl, J. B. Circulating tumor DNA as a liquid biopsy for cancer. Clin. Chem. 61, 112–123 (2015)
-
(2015)
Clin. Chem.
, vol.61
, pp. 112-123
-
-
Heitzer, E.1
Ulz, P.2
Geigl, J.B.3
-
13
-
-
84906731563
-
Challenges in circulating tumour cell research
-
COI: 1:CAS:528:DC%2BC2cXhsVWktrfM, PID: 25154812
-
Alix-Panabieres, C. & Pantel, K. Challenges in circulating tumour cell research. Nat. Rev. Cancer 14, 623–631 (2014)
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 623-631
-
-
Alix-Panabieres, C.1
Pantel, K.2
-
14
-
-
84964700391
-
Clinical applications of circulating tumor cells and circulating tumor dna as liquid biopsy
-
COI: 1:CAS:528:DC%2BC28XntlOqsro%3D, PID: 26969689
-
Alix-Panabieres, C. & Pantel, K. Clinical applications of circulating tumor cells and circulating tumor dna as liquid biopsy. Cancer Discov. 6, 479–491 (2016)
-
(2016)
Cancer Discov.
, vol.6
, pp. 479-491
-
-
Alix-Panabieres, C.1
Pantel, K.2
-
15
-
-
85012886951
-
Liquid biopsies, what we do not know (yet)
-
COI: 1:CAS:528:DC%2BC2sXis1ylt7Y%3D, PID: 28196593
-
Bardelli, A. & Pantel, K. Liquid biopsies, what we do not know (yet). Cancer Cell 31, 172–179 (2017)
-
(2017)
Cancer Cell
, vol.31
, pp. 172-179
-
-
Bardelli, A.1
Pantel, K.2
-
16
-
-
85032643760
-
A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies
-
PID: 29089558
-
Amorim, M. G. et al. A total transcriptome profiling method for plasma-derived extracellular vesicles: applications for liquid biopsies. Sci. Rep. 7, 14395 (2017)
-
(2017)
Sci. Rep.
, vol.7
-
-
Amorim, M.G.1
-
17
-
-
84888119068
-
Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing
-
COI: 1:CAS:528:DC%2BC3sXhvFCis7%2FL, PID: 24191000
-
Chan, K. C. et al. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proc. Natl Acad. Sci. USA 110, 18761–18768 (2013)
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 18761-18768
-
-
Chan, K.C.1
-
18
-
-
84976548542
-
Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer
-
COI: 1:CAS:528:DC%2BC28XhtFSisbjF, PID: 27350604
-
Kim, Y. et al. Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer. Nat. Commun. 7, 11906 (2016)
-
(2016)
Nat. Commun.
, vol.7
-
-
Kim, Y.1
-
19
-
-
84921950738
-
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
-
COI: 1:CAS:528:DC%2BC2cXhs1ehsr3E, PID: 25261994
-
Mayers, J. R. et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat. Med. 20, 1193–1198 (2014)
-
(2014)
Nat. Med.
, vol.20
, pp. 1193-1198
-
-
Mayers, J.R.1
-
20
-
-
85041308556
-
Machine learning to detect signatures of disease in liquid biopsies — a user’s guide
-
COI: 1:CAS:528:DC%2BC2sXhvVGmt73E, PID: 29192299
-
Ko, J. et al. Machine learning to detect signatures of disease in liquid biopsies — a user’s guide. Lab. Chip 18, 395–405 (2018)
-
(2018)
Lab. Chip
, vol.18
, pp. 395-405
-
-
Ko, J.1
-
21
-
-
59849108152
-
The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group
-
PID: 18813139
-
Teutsch, S. M. et al. The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: methods of the EGAPP Working Group. Genet. Med. 11, 3–14 (2009)
-
(2009)
Genet. Med.
, vol.11
, pp. 3-14
-
-
Teutsch, S.M.1
-
22
-
-
84928572844
-
Biomarker validation and testing
-
PID: 25458054
-
Hayes, D. F. Biomarker validation and testing. Mol. Oncol. 9, 960–966 (2015)
-
(2015)
Mol. Oncol.
, vol.9
, pp. 960-966
-
-
Hayes, D.F.1
-
23
-
-
85049756854
-
Precision medicine and testing for tumor biomarkers — Are all tests born equal?
-
Hayes, D. F. Precision medicine and testing for tumor biomarkers — are all tests born equal? JAMA Oncol. 4, 773–774 (2017)
-
(2017)
JAMA Oncol.
, vol.4
, pp. 773-774
-
-
Hayes, D.F.1
-
24
-
-
4143094988
-
Circulating tumor cells, disease progression, and survival in metastatic breast cancer
-
COI: 1:CAS:528:DC%2BD2cXntVeitb4%3D, PID: 15317891
-
Cristofanilli, M. et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N. Engl. J. Med. 351, 781–791 (2004)
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 781-791
-
-
Cristofanilli, M.1
-
25
-
-
20144385756
-
Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer
-
PID: 15735118
-
Cristofanilli, M. et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J. Clin. Oncol. 23, 1420–1430 (2005)
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1420-1430
-
-
Cristofanilli, M.1
-
26
-
-
33847402612
-
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system
-
COI: 1:CAS:528:DC%2BD2sXhsVyrsL0%3D, PID: 17289886
-
Riethdorf, S. et al. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin. Cancer Res. 13, 920–928 (2007)
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 920-928
-
-
Riethdorf, S.1
-
27
-
-
42649100970
-
Detection, clinical relevance and specific biological properties of disseminating tumour cells
-
COI: 1:CAS:528:DC%2BD1cXltVGlurs%3D, PID: 18404148
-
Pantel, K., Brakenhoff, R. H. & Brandt, B. Detection, clinical relevance and specific biological properties of disseminating tumour cells. Nat. Rev. Cancer 8, 329–340 (2008)
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 329-340
-
-
Pantel, K.1
Brakenhoff, R.H.2
Brandt, B.3
-
28
-
-
85051841054
-
Circulating tumor cells in breast cancer patients treated by neoadjuvant chemotherapy: a meta-analysis
-
PID: 29659933
-
Bidard, F. C. et al. Circulating tumor cells in breast cancer patients treated by neoadjuvant chemotherapy: a meta-analysis. J. Natl Cancer Inst. 110, 560–567 (2018)
-
(2018)
J. Natl Cancer Inst.
, vol.110
, pp. 560-567
-
-
Bidard, F.C.1
-
29
-
-
84897445481
-
Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data
-
PID: 24636208
-
Bidard, F. C. et al. Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data. Lancet Oncol. 15, 406–414 (2014)
-
(2014)
Lancet Oncol.
, vol.15
, pp. 406-414
-
-
Bidard, F.C.1
-
30
-
-
58149165081
-
Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
-
PID: 18829513
-
de Bono, J. S. et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin. Cancer Res. 14, 6302–6309 (2008)
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 6302-6309
-
-
de Bono, J.S.1
-
31
-
-
85019242735
-
Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first- and second-line abiraterone and enzalutamide
-
COI: 1:CAS:528:DC%2BC1cXhvFKnsL%2FK, PID: 28384066
-
Antonarakis, E. S. et al. Clinical significance of androgen receptor splice variant-7 mRNA detection in circulating tumor cells of men with metastatic castration-resistant prostate cancer treated with first- and second-line abiraterone and enzalutamide. J. Clin. Oncol. 35, 2149–2156 (2017)
-
(2017)
J. Clin. Oncol.
, vol.35
, pp. 2149-2156
-
-
Antonarakis, E.S.1
-
32
-
-
84992659976
-
Decline in circulating tumor cell count and treatment outcome in advanced prostate cancer
-
PID: 27289566
-
Lorente, D. et al. Decline in circulating tumor cell count and treatment outcome in advanced prostate cancer. Eur. Urol. 70, 985–992 (2016)
-
(2016)
Eur. Urol.
, vol.70
, pp. 985-992
-
-
Lorente, D.1
-
33
-
-
85042047569
-
Circulating tumor cell number as a response measure of prolonged survival for metastatic castration-resistant prostate cancer: a comparison with prostate-specific antigen across five randomized phase III clinical trials
-
COI: 1:CAS:528:DC%2BC1cXitFOqtLzM, PID: 29272162
-
Heller, G. et al. Circulating tumor cell number as a response measure of prolonged survival for metastatic castration-resistant prostate cancer: a comparison with prostate-specific antigen across five randomized phase III clinical trials. J. Clin. Oncol. 36, 572–580 (2018)
-
(2018)
J. Clin. Oncol.
, vol.36
, pp. 572-580
-
-
Heller, G.1
-
34
-
-
49249130844
-
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
-
PID: 18591556
-
Cohen, S. J. et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J. Clin. Oncol. 26, 3213–3221 (2008)
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 3213-3221
-
-
Cohen, S.J.1
-
35
-
-
84926382140
-
Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer
-
PID: 25880692
-
Huang, X. et al. Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer. BMC Cancer 15, 202 (2015)
-
(2015)
BMC Cancer
, vol.15
-
-
Huang, X.1
-
36
-
-
85044525388
-
Clinical applications of the CellSearch platform in cancer patients
-
COI: 1:CAS:528:DC%2BC1cXitl2qtbk%3D, PID: 29355669
-
Riethdorf, S., O’Flaherty, L., Hille, C. & Pantel, K. Clinical applications of the CellSearch platform in cancer patients. Adv. Drug. Deliv. Rev. 125, 102–121 (2018)
-
(2018)
Adv. Drug. Deliv. Rev.
, vol.125
, pp. 102-121
-
-
Riethdorf, S.1
O’Flaherty, L.2
Hille, C.3
Pantel, K.4
-
37
-
-
84975461688
-
Prospective validation of rapid plasma genotyping for the detection of EGFR and KRAS mutations in advanced lung cancer
-
PID: 27055085
-
Sacher, A. G. et al. Prospective validation of rapid plasma genotyping for the detection of EGFR and KRAS mutations in advanced lung cancer. JAMA Oncol. 2, 1014–1022 (2016)
-
(2016)
JAMA Oncol.
, vol.2
, pp. 1014-1022
-
-
Sacher, A.G.1
-
38
-
-
84911866971
-
Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline
-
PID: 25311215
-
Leighl, N. B. et al. Molecular testing for selection of patients with lung cancer for epidermal growth factor receptor and anaplastic lymphoma kinase tyrosine kinase inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline. J. Clin. Oncol. 32, 3673–3679 (2014)
-
(2014)
J. Clin. Oncol.
, vol.32
, pp. 3673-3679
-
-
Leighl, N.B.1
-
39
-
-
83355163991
-
Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
-
COI: 1:CAS:528:DC%2BC38XisFyrsbg%3D, PID: 22168215
-
Warren, J. D. et al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 9, 133 (2011)
-
(2011)
BMC Med.
, vol.9
-
-
Warren, J.D.1
-
40
-
-
85020637333
-
The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: a meta-analysis
-
PID: 28596563
-
Song, L., Jia, J., Peng, X., Xiao, W. & Li, Y. The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: a meta-analysis. Sci. Rep. 7, 3032 (2017)
-
(2017)
Sci. Rep.
, vol.7
-
-
Song, L.1
Jia, J.2
Peng, X.3
Xiao, W.4
Li, Y.5
-
41
-
-
85036637362
-
Diagnostic accuracy of methylated SEPT9 for blood-based colorectal cancer detection: a systematic review and meta-analysis
-
COI: 1:CAS:528:DC%2BC2sXht1Orsbo%3D, PID: 28102859
-
Nian, J. et al. Diagnostic accuracy of methylated SEPT9 for blood-based colorectal cancer detection: a systematic review and meta-analysis. Clin. Transl Gastroenterol. 8, e216 (2017)
-
(2017)
Clin. Transl Gastroenterol.
, vol.8
-
-
Nian, J.1
-
42
-
-
84941629860
-
First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study
-
PID: 26105600
-
Wu, Y. L. et al. First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label, ENSURE study. Ann. Oncol. 26, 1883–1889 (2015)
-
(2015)
Ann. Oncol.
, vol.26
, pp. 1883-1889
-
-
Wu, Y.L.1
-
43
-
-
85042667463
-
Updated molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors guideline from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology
-
PID: 29355391
-
Lindeman, N. I. et al. Updated molecular testing guideline for the selection of lung cancer patients for treatment with targeted tyrosine kinase inhibitors guideline from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology. Arch. Pathol. Lab. Med. 142, 321–346 (2018)
-
(2018)
Arch. Pathol. Lab. Med.
, vol.142
, pp. 321-346
-
-
Lindeman, N.I.1
-
44
-
-
84954306330
-
Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin
-
COI: 1:CAS:528:DC%2BC28XhtFShsbs%3D, PID: 26771485
-
Snyder, M. W., Kircher, M., Hill, A. J., Daza, R. M. & Shendure, J. Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin. Cell 164, 57–68 (2016)
-
(2016)
Cell
, vol.164
, pp. 57-68
-
-
Snyder, M.W.1
Kircher, M.2
Hill, A.J.3
Daza, R.M.4
Shendure, J.5
-
45
-
-
84984616776
-
Inferring expressed genes by whole-genome sequencing of plasma DNA
-
COI: 1:CAS:528:DC%2BC28XhsVWksL%2FI, PID: 27571261, This paper reports the use of machine learning for gene classification based on differential read depth patterns at transcription start sites, which reflect nucleosome occupancy patterns
-
Ulz, P. et al. Inferring expressed genes by whole-genome sequencing of plasma DNA. Nat. Genet. 48, 1273–1278 (2016). This paper reports the use of machine learning for gene classification based on differential read depth patterns at transcription start sites, which reflect nucleosome occupancy patterns
-
(2016)
Nat. Genet.
, vol.48
, pp. 1273-1278
-
-
Ulz, P.1
-
46
-
-
84946719441
-
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
-
PID: 26554728
-
De Mattos-Arruda, L. et al. Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma. Nat. Commun. 6, 8839 (2015)
-
(2015)
Nat. Commun.
, vol.6
-
-
De Mattos-Arruda, L.1
-
47
-
-
84906890825
-
Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle
-
PID: 25009010
-
De Mattos-Arruda, L. et al. Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle. Ann. Oncol. 25, 1729–1735 (2014)
-
(2014)
Ann. Oncol.
, vol.25
, pp. 1729-1735
-
-
De Mattos-Arruda, L.1
-
48
-
-
84964767208
-
Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer
-
COI: 1:STN:280:DC%2BC28nlsVGmsg%3D%3D, PID: 26823523
-
Jamal-Hanjani, M. et al. Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer. Ann. Oncol. 27, 862–867 (2016)
-
(2016)
Ann. Oncol.
, vol.27
, pp. 862-867
-
-
Jamal-Hanjani, M.1
-
49
-
-
84946559772
-
Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer
-
PID: 26530965
-
Murtaza, M. et al. Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer. Nat. Commun. 6, 8760 (2015)
-
(2015)
Nat. Commun.
, vol.6
-
-
Murtaza, M.1
-
50
-
-
84899114624
-
Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer
-
COI: 1:CAS:528:DC%2BC2cXovVKgsr0%3D, PID: 24685572
-
Kuo, Y. B., Chen, J. S., Fan, C. W., Li, Y. S. & Chan, E. C. Comparison of KRAS mutation analysis of primary tumors and matched circulating cell-free DNA in plasmas of patients with colorectal cancer. Clin. Chim. Acta 433, 284–289 (2014)
-
(2014)
Clin. Chim. Acta
, vol.433
, pp. 284-289
-
-
Kuo, Y.B.1
Chen, J.S.2
Fan, C.W.3
Li, Y.S.4
Chan, E.C.5
-
51
-
-
84990050278
-
Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC28XhvFertr3E, PID: 27354477
-
Oxnard, G. R. et al. Association between plasma genotyping and outcomes of treatment with osimertinib (AZD9291) in advanced non-small-cell lung cancer. J. Clin. Oncol. 34, 3375–3382 (2016)
-
(2016)
J. Clin. Oncol.
, vol.34
, pp. 3375-3382
-
-
Oxnard, G.R.1
-
52
-
-
84936748494
-
Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
-
COI: 1:CAS:528:DC%2BC2MXhtFeisrrI, PID: 26030179
-
Siravegna, G. et al. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. Nat. Med. 21, 795 (2015)
-
(2015)
Nat. Med.
, vol.21
, pp. 795
-
-
Siravegna, G.1
-
53
-
-
84975744385
-
Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
-
COI: 1:CAS:528:DC%2BC28XhtVKitb%2FP, PID: 27328849
-
Ulz, P. et al. Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer. Nat. Commun. 7, 12008 (2016)
-
(2016)
Nat. Commun.
, vol.7
-
-
Ulz, P.1
-
54
-
-
84896371874
-
Detection of circulating tumor DNA in early- and late-stage human malignancies
-
This study evaluates 640 patients with different cancer types and reports a high variability of ctDNA patients with the same tumour entities and disease stages
-
Bettegowda, C. et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci. Transl Med. 6, 224ra224 (2014). This study evaluates 640 patients with different cancer types and reports a high variability of ctDNA in patients with the same tumour entities and disease stages
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 224ra224
-
-
Bettegowda, C.1
-
55
-
-
84907285681
-
Tumor clone dynamics in lethal prostate cancer
-
PID: 25232177
-
Carreira, S. et al. Tumor clone dynamics in lethal prostate cancer. Sci. Transl Med. 6, 254ra125 (2014)
-
(2014)
Sci. Transl. Med.
, vol.6
, pp. 254ra125
-
-
Carreira, S.1
-
56
-
-
84903218109
-
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
-
COI: 1:CAS:528:DC%2BC2cXls1Kjt70%3D, PID: 24705333, This study demonstrates that the combination of UMIs with highly sophisticated bioinformatics algorithms can substantially improve the sensitivity of sequencing-based approaches
-
Newman, A. M. et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat. Med. 20, 548–554 (2014). This study demonstrates that the combination of UMIs with highly sophisticated bioinformatics algorithms can substantially improve the sensitivity of sequencing-based approaches
-
(2014)
Nat. Med.
, vol.20
, pp. 548-554
-
-
Newman, A.M.1
-
57
-
-
84996489062
-
Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA
-
PID: 27831904
-
Scherer, F. et al. Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA. Sci Transl Med. 8, 364ra155 (2016)
-
(2016)
Sci Transl Med.
, vol.8
, pp. 364ra155
-
-
Scherer, F.1
-
59
-
-
85019743651
-
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
-
COI: 1:CAS:528:DC%2BC2sXosVansrw%3D, PID: 28445469, This study uses a tumour-specific phylogenetic approach to track the subclonal nature of lung cancer relapse and metastasis. addition, independent predictors of ctDNA release were identified and correlations of the tumour volume and ctDNA allele frequencies were described
-
Abbosh, C. et al. Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution. Nature 545, 446–451 (2017). This study uses a tumour-specific phylogenetic approach to track the subclonal nature of lung cancer relapse and metastasis. In addition, independent predictors of ctDNA release were identified and correlations of the tumour volume and ctDNA allele frequencies were described
-
(2017)
Nature
, vol.545
, pp. 446-451
-
-
Abbosh, C.1
-
60
-
-
85007602110
-
Exploratory analysis of TP53 mutations in circulating tumour DNA as biomarkers of treatment response for patients with relapsed high-grade serous ovarian carcinoma: a retrospective study
-
PID: 27997533, This study demonstrates that TP53 mutations can be used as personalized markers to monitor tumour burden and early changes as a predictor of response and time to progression patients with HGSOC
-
Parkinson, C. A. et al. Exploratory analysis of TP53 mutations in circulating tumour DNA as biomarkers of treatment response for patients with relapsed high-grade serous ovarian carcinoma: a retrospective study. PLOS Med. 13, e1002198 (2016). This study demonstrates that TP53 mutations can be used as personalized markers to monitor tumour burden and early changes as a predictor of response and time to progression in patients with HGSOC
-
(2016)
PLOS Med.
, vol.13
-
-
Parkinson, C.A.1
-
61
-
-
85037348094
-
Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling
-
Chaudhuri, A. A. et al. Early detection of molecular residual disease in localized lung cancer by circulating tumor DNA profiling. Cancer Discov. 12, 1394–1403 (2017)
-
(2017)
Cancer Discov.
, vol.12
, pp. 1394-1403
-
-
Chaudhuri, A.A.1
-
62
-
-
84941630950
-
Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
-
COI: 1:STN:280:DC%2BC2MjhvVyhsw%3D%3D
-
Tie, J. et al. Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer. Ann. Oncol. 26, 1715–1722 (2015)
-
(2015)
Anna. Oncol.
, vol.26
, pp. 1715-1722
-
-
Tie, J.1
-
63
-
-
84978062740
-
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
-
Tie, J. et al. Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer. Sci. Transl Med. 8, 346ra392 (2016)
-
(2016)
Sci. Transl. Med.
, vol.8
, pp. 346ra392
-
-
Tie, J.1
-
64
-
-
84938414305
-
Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease
-
COI: 1:CAS:528:DC%2BC2MXosVejtrY%3D, PID: 25987569
-
Olsson, E. et al. Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. EMBO Mol. Med. 7, 1034–1047 (2015)
-
(2015)
EMBO Mol. Med.
, vol.7
, pp. 1034-1047
-
-
Olsson, E.1
-
65
-
-
84863000299
-
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
-
COI: 1:CAS:528:DC%2BC38XpsVSrtLg%3D, PID: 22722843
-
Diaz, L. A. Jr. et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature 486, 537–540 (2012)
-
(2012)
Nature
, vol.486
, pp. 537-540
-
-
Diaz, L.A.1
-
66
-
-
84908431348
-
Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution
-
COI: 1:CAS:528:DC%2BC2cXhvVyju7nP, PID: 25293556
-
Misale, S., Di Nicolantonio, F., Sartore-Bianchi, A., Siena, S. & Bardelli, A. Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution. Cancer Discov. 4, 1269–1280 (2014)
-
(2014)
Cancer Discov.
, vol.4
, pp. 1269-1280
-
-
Misale, S.1
Di Nicolantonio, F.2
Sartore-Bianchi, A.3
Siena, S.4
Bardelli, A.5
-
67
-
-
84862999938
-
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
-
COI: 1:CAS:528:DC%2BC38XpsVSrsb4%3D, PID: 22722830
-
Misale, S. et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 486, 532–U131 (2012)
-
(2012)
Nature
, vol.486
, pp. 131-532
-
-
Misale, S.1
-
68
-
-
84897389811
-
Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing
-
PID: 24676216
-
Mohan, S. et al. Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing. PLOS Genet. 10, e1004271 (2014)
-
(2014)
PLOS Genet.
, vol.10
-
-
Mohan, S.1
-
69
-
-
85021730166
-
Predicting treatment resistance and relapse through circulating DNA
-
PID: 28694015
-
Beddowes, E., Sammut, S. J., Gao, M. & Caldas, C. Predicting treatment resistance and relapse through circulating DNA. Breast 34, S31–S35 (2017)
-
(2017)
Breast
, vol.34
, pp. S31-S35
-
-
Beddowes, E.1
Sammut, S.J.2
Gao, M.3
Caldas, C.4
-
70
-
-
84877579861
-
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
-
COI: 1:CAS:528:DC%2BC3sXltlOls7k%3D
-
Murtaza, M. et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 497, 108–112 (2013)
-
(2013)
Nature
, vol.497
, pp. 108-112
-
-
Murtaza, M.1
-
71
-
-
59449108664
-
9 still really fit one gram of tumor tissue?
-
PID: 19176997
-
9 still really fit one gram of tumor tissue? Cell Cycle 8, 505–506 (2009)
-
(2009)
Cell Cycle
, vol.8
, pp. 505-506
-
-
Del Monte, U.1
-
72
-
-
84906827268
-
The dynamic range of circulating tumor DNA in metastatic breast cancer
-
PID: 25107527
-
Heidary, M. et al. The dynamic range of circulating tumor DNA in metastatic breast cancer. Breast Cancer Res. 16, 421 (2014)
-
(2014)
Breast Cancer Res.
, vol.16
-
-
Heidary, M.1
-
73
-
-
84877806778
-
Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer
-
COI: 1:CAS:528:DC%2BC3sXisVSlurw%3D, PID: 23319339
-
Heitzer, E. et al. Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer. Int. J. Cancer 133, 346–356 (2013)
-
(2013)
Int. J. Cancer
, vol.133
, pp. 346-356
-
-
Heitzer, E.1
-
74
-
-
84966365311
-
Integrated digital error suppression for improved detection of circulating tumor DNA
-
COI: 1:CAS:528:DC%2BC28XkvV2itb8%3D, PID: 27018799
-
Newman, A. M. et al. Integrated digital error suppression for improved detection of circulating tumor DNA. Nat. Biotechnol. 34, 547–555 (2016)
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 547-555
-
-
Newman, A.M.1
-
75
-
-
85025098177
-
Characterization of background noise in capture-based targeted sequencing data
-
PID: 28732520
-
Park, G. et al. Characterization of background noise in capture-based targeted sequencing data. Genome Biol. 18, 136 (2017)
-
(2017)
Genome Biol.
, vol.18
-
-
Park, G.1
-
76
-
-
79959353421
-
Detection and quantification of rare mutations with massively parallel sequencing
-
PID: 21586637
-
Kinde, I., Wu, J., Papadopoulos, N., Kinzler, K. W. & Vogelstein, B. Detection and quantification of rare mutations with massively parallel sequencing. Proc. Natl Acad. Sci. USA 108, 9530–9535 (2011)
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 9530-9535
-
-
Kinde, I.1
Wu, J.2
Papadopoulos, N.3
Kinzler, K.W.4
Vogelstein, B.5
-
77
-
-
84861746437
-
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
-
Forshew, T. et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci. Transl Med. 4, 136ra168 (2012)
-
(2012)
Sci. Transl. Med.
, vol.4
, pp. 136ra168
-
-
Forshew, T.1
-
78
-
-
84865979581
-
Detection of ultra-rare mutations by next-generation sequencing
-
COI: 1:CAS:528:DC%2BC38XhsVaqu77E, PID: 22853953
-
Schmitt, M. W. et al. Detection of ultra-rare mutations by next-generation sequencing. Proc. Natl Acad. Sci. USA 109, 14508–14513 (2012)
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 14508-14513
-
-
Schmitt, M.W.1
-
79
-
-
85027717075
-
Direct detection of early-stage cancers using circulating tumor DNA
-
PID: 28814544, this study, high-resolution gene panel profiling (TEC-Seq) is employed for non-invasive detection of early-stage tumours 200 patients with stage I or II colorectal, breast, lung or ovarian cancer
-
Phallen, J. et al. Direct detection of early-stage cancers using circulating tumor DNA. Sci. Transl Med. 9, eaan2415 (2017). In this study, high-resolution gene panel profiling (TEC-Seq) is employed for non-invasive detection of early-stage tumours in 200 patients with stage I or II colorectal, breast, lung or ovarian cancer
-
(2017)
Sci. Transl. Med.
, vol.9
-
-
Phallen, J.1
-
80
-
-
85016502865
-
UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy
-
COI: 1:CAS:528:DC%2BC2sXhtVaiu7fL, PID: 28100584
-
Smith, T., Heger, A. & Sudbery, I. UMI-tools: modeling sequencing errors in unique molecular identifiers to improve quantification accuracy. Genome Res. 27, 491–499 (2017)
-
(2017)
Genome Res.
, vol.27
, pp. 491-499
-
-
Smith, T.1
Heger, A.2
Sudbery, I.3
-
81
-
-
84925338452
-
Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
-
COI: 1:CAS:528:DC%2BC2MXhvFCgsLk%3D, PID: 25646427
-
Jiang, P. et al. Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients. Proc. Natl Acad. Sci. USA 112, E1317–E1325 (2015)
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E1317-E1325
-
-
Jiang, P.1
-
82
-
-
84982840399
-
Fragment length of circulating tumor DNA
-
PID: 27428049
-
Underhill, H. R. et al. Fragment length of circulating tumor DNA. PLOS Genet. 12, e1006162 (2016)
-
(2016)
PLOS Genet.
, vol.12
-
-
Underhill, H.R.1
-
83
-
-
84964671215
-
The long and short of circulating cell-free DNA and the ins and outs of molecular diagnostics
-
COI: 1:CAS:528:DC%2BC28Xmtleitr4%3D, PID: 27129983
-
Jiang, P. Y. & Lo, Y. M. D. The long and short of circulating cell-free DNA and the ins and outs of molecular diagnostics. Trends Genet. 32, 360–371 (2016)
-
(2016)
Trends Genet.
, vol.32
, pp. 360-371
-
-
Jiang, P.Y.1
Lo, Y.M.D.2
-
84
-
-
78650207098
-
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
-
COI: 1:CAS:528:DC%2BC3MXhsFKqurk%3D, PID: 21148127
-
Lo, Y. M. D. et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci. Transl Med. 2, 61ra91 (2010)
-
(2010)
Sci. Transl. Med.
, vol.2
, pp. 61ra91
-
-
Lo, Y.M.D.1
-
85
-
-
85030773268
-
Single-stranded DNA library preparation does not preferentially enrich circulating tumor DNA
-
COI: 1:CAS:528:DC%2BC1cXjtlehs7Y%3D, PID: 28807979
-
Moser, T. et al. Single-stranded DNA library preparation does not preferentially enrich circulating tumor DNA. Clin. Chem. 63, 1656–1659 (2017)
-
(2017)
Clin. Chem.
, vol.63
, pp. 1656-1659
-
-
Moser, T.1
-
86
-
-
85018353176
-
Single-stranded DNA library preparation preferentially enriches short maternal DNA in maternal plasma
-
COI: 1:CAS:528:DC%2BC2sXhtF2gtrvF, PID: 28280050
-
Vong, J. S. L. et al. Single-stranded DNA library preparation preferentially enriches short maternal DNA in maternal plasma. Clin. Chem. 63, 1031–1037 (2017)
-
(2017)
Clin. Chem.
, vol.63
, pp. 1031-1037
-
-
Vong, J.S.L.1
-
87
-
-
85047929804
-
Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing
-
COI: 1:CAS:528:DC%2BC1cXhvVOltL%2FM, PID: 29760053, The authors investigate whether preferred end sites might bear any relationship with fragment lengths of plasma DNA. Short and long plasma DNA molecules were associated with different preferred DNA end sites
-
Sun, K. et al. Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing. Proc. Natl Acad. Sci. USA 115, E5106–E5114 (2018). The authors investigate whether preferred end sites might bear any relationship with fragment lengths of plasma DNA. Short and long plasma DNA molecules were associated with different preferred DNA end sites
-
(2018)
Proc. Natl Acad. Sci. USA
, vol.115
, pp. E5106-E5114
-
-
Sun, K.1
-
88
-
-
84991669713
-
Tissue-specific mutation accumulation in human adult stem cells during life
-
COI: 1:CAS:528:DC%2BC28Xhs1SltLbO, PID: 5536223
-
Blokzijl, F. et al. Tissue-specific mutation accumulation in human adult stem cells during life. Nature 538, 260–264 (2016)
-
(2016)
Nature
, vol.538
, pp. 260-264
-
-
Blokzijl, F.1
-
89
-
-
84921288028
-
Variation in cancer risk among tissues can be explained by the number of stem cell divisions
-
COI: 1:CAS:528:DC%2BC2MXhsFyksQ%3D%3D, PID: 25554788
-
Tomasetti, C. & Vogelstein, B. Variation in cancer risk among tissues can be explained by the number of stem cell divisions. Science 347, 78–81 (2015)
-
(2015)
Science
, vol.347
, pp. 78-81
-
-
Tomasetti, C.1
Vogelstein, B.2
-
90
-
-
84952639987
-
Aging-induced stem cell mutations as drivers for disease and cancer
-
COI: 1:CAS:528:DC%2BC2MXos1Oltbc%3D, PID: 26046760
-
Adams, P. D., Jasper, H. & Rudolph, K. L. Aging-induced stem cell mutations as drivers for disease and cancer. Cell Stem Cell 16, 601–612 (2015)
-
(2015)
Cell Stem Cell
, vol.16
, pp. 601-612
-
-
Adams, P.D.1
Jasper, H.2
Rudolph, K.L.3
-
91
-
-
84920024296
-
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
-
PID: 4290021
-
Genovese, G. et al. Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence. N. Engl. J. Med. 371, 2477–2487 (2014)
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2477-2487
-
-
Genovese, G.1
-
92
-
-
84920053873
-
Age-related clonal hematopoiesis associated with adverse outcomes
-
PID: 4306669
-
Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adverse outcomes. N. Engl. J. Med. 371, 2488–2498 (2014)
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 2488-2498
-
-
Jaiswal, S.1
-
93
-
-
84930003179
-
Age-related mutations associated with clonal hematopoietic expansion and malignancies
-
COI: 1:CAS:528:DC%2BC2cXhslOisrvI, PID: 25326804
-
Xie, M. C. et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nat. Med. 20, 1472–1478 (2014)
-
(2014)
Nat. Med.
, vol.20
, pp. 1472-1478
-
-
Xie, M.C.1
-
94
-
-
85056322551
-
Prevalence of clonal hematopoiesis mutations in tumor-only clinical genomic profiling of solid tumors
-
This study demonstrates how clonal haematopoiesis-derived mutations could lead to erroneous reporting and treatment recommendations when tumour-only sequencing is used
-
Ptashkin, R. N. et al. Prevalence of clonal hematopoiesis mutations in tumor-only clinical genomic profiling of solid tumors. JAMA Oncol. 10.1001/jamaoncol.2018.2297(2018). This study demonstrates how clonal haematopoiesis-derived mutations could lead to erroneous reporting and treatment recommendations when tumour-only sequencing is used
-
(2018)
JAMA Oncol
-
-
Ptashkin, R.N.1
-
95
-
-
85056321419
-
Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays
-
Coombs, C. C. et al. Identification of clonal hematopoiesis mutations in solid tumor patients undergoing unpaired next-generation sequencing assays. Clin. Cancer Res. 10.1158/1078-0432.CCR-18-1201 (2018)
-
(2018)
Clin. Cancer Res.
-
-
Coombs, C.C.1
-
96
-
-
85051683086
-
False positive plasma genotyping due to clonal hematopoiesis
-
Hu, Y. et al. False positive plasma genotyping due to clonal hematopoiesis. Clin. Cancer Res. 10.1158/1078-0432.CCR-18-0143 (2018)
-
(2018)
Clin. Cancer Res.
-
-
Hu, Y.1
-
97
-
-
84861628224
-
Detectable clonal mosaicism and its relationship to aging and cancer
-
COI: 1:CAS:528:DC%2BC38XmsFOrt7g%3D, PID: 22561519
-
Jacobs, K. B. et al. Detectable clonal mosaicism and its relationship to aging and cancer. Nat. Genet. 44, 651–668 (2012)
-
(2012)
Nat. Genet.
, vol.44
, pp. 651-668
-
-
Jacobs, K.B.1
-
98
-
-
84868130720
-
Extensive genetic variation in somatic human tissues
-
PID: 23043118
-
O’Huallachain, M., Karczewski, K. J., Weissman, S. M., Urban, A. E. & Snyder, M. P. Extensive genetic variation in somatic human tissues. Proc. Natl Acad. Sci. USA 109, 18018–18023 (2012)
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 18018-18023
-
-
O’Huallachain, M.1
Karczewski, K.J.2
Weissman, S.M.3
Urban, A.E.4
Snyder, M.P.5
-
99
-
-
84907737648
-
Genome sequencing of normal cells reveals developmental lineages and mutational processes
-
COI: 1:CAS:528:DC%2BC2cXhsFOlu7jI, PID: 25043003
-
Behjati, S. et al. Genome sequencing of normal cells reveals developmental lineages and mutational processes. Nature 513, 422–425 (2014)
-
(2014)
Nature
, vol.513
, pp. 422-425
-
-
Behjati, S.1
-
100
-
-
84969850944
-
Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues
-
COI: 1:CAS:528:DC%2BC28XntlSrsbs%3D, PID: 27152024
-
Krimmel, J. D. et al. Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues. Proc. Natl Acad. Sci. USA 113, 6005–6010 (2016)
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 6005-6010
-
-
Krimmel, J.D.1
-
101
-
-
85027949239
-
Identification of circulating tumor DNA for the early detection of small-cell lung cancer
-
PID: 27377626
-
Fernandez-Cuesta, L. et al. Identification of circulating tumor DNA for the early detection of small-cell lung cancer. EBioMedicine 10, 117–123 (2016)
-
(2016)
EBioMedicine
, vol.10
, pp. 117-123
-
-
Fernandez-Cuesta, L.1
-
102
-
-
85051124630
-
Validation of a plasma-based comprehensive cancer genotyping assay utilizing orthogonal tissue- and plasma-based methodologies
-
COI: 1:CAS:528:DC%2BC1cXhsVWrtr3M, PID: 29691297
-
Odegaard, J. I. et al. Validation of a plasma-based comprehensive cancer genotyping assay utilizing orthogonal tissue- and plasma-based methodologies. Clin. Cancer Res. 24, 3539–3549 (2018)
-
(2018)
Clin. Cancer Res.
, vol.24
, pp. 3539-3549
-
-
Odegaard, J.I.1
-
103
-
-
85049728043
-
Patient-paired sample congruence between 2 commercial liquid biopsy tests
-
Torga, G. & Pienta, K. J. Patient-paired sample congruence between 2 commercial liquid biopsy tests. JAMA Oncol. 4, 868–870 (2017)
-
(2017)
JAMA Oncol.
, vol.4
, pp. 868-870
-
-
Torga, G.1
Pienta, K.J.2
-
104
-
-
85048218708
-
Circulating tumor DNA analysis in patients with cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review
-
Merker, J. D. et al. Circulating tumor DNA analysis in patients with cancer: American Society of Clinical Oncology and College of American Pathologists joint review. J. Clin. Oncol. 16, 1631–1641 (2018)
-
(2018)
J. Clin. Oncol.
, vol.16
, pp. 1631-1641
-
-
Merker, J.D.1
-
105
-
-
85017654995
-
Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium
-
COI: 1:STN:280:DC%2BC1c3lslehtw%3D%3D, PID: 28187516
-
Grossman, R. L. et al. Collaborating to compete: Blood Profiling Atlas in Cancer (BloodPAC) Consortium. Clin. Pharmacol. Ther. 101, 589–592 (2017)
-
(2017)
Clin. Pharmacol. Ther.
, vol.101
, pp. 589-592
-
-
Grossman, R.L.1
-
106
-
-
85021356559
-
Emerging applications of exosomes in cancer therapeutics and diagnostics
-
COI: 1:CAS:528:DC%2BC2sXhtFChtr3K, PID: 28529978
-
Inamdar, S., Nitiyanandan, R. & Rege, K. Emerging applications of exosomes in cancer therapeutics and diagnostics. Bioeng. Transl Med. 2, 70–80 (2017)
-
(2017)
Bioeng. Transl Med.
, vol.2
, pp. 70-80
-
-
Inamdar, S.1
Nitiyanandan, R.2
Rege, K.3
-
107
-
-
85027221443
-
Swarm intelligence-enhanced detection of non-small-cell lung cancer using tumor-educated platelets
-
COI: 1:CAS:528:DC%2BC2sXhtlClsbjF, PID: 28810146
-
Best, M. G. et al. Swarm intelligence-enhanced detection of non-small-cell lung cancer using tumor-educated platelets. Cancer Cell 32, 238–252 (2017)
-
(2017)
Cancer Cell
, vol.32
, pp. 238-252
-
-
Best, M.G.1
-
108
-
-
84946568126
-
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
-
COI: 1:CAS:528:DC%2BC2MXhslGmtr7L, PID: 26525104
-
Best, M. G. et al. RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell 28, 666–676 (2015)
-
(2015)
Cancer Cell
, vol.28
, pp. 666-676
-
-
Best, M.G.1
-
109
-
-
84987719019
-
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
-
COI: 1:CAS:528:DC%2BC28XhsVKjsLzO, PID: 27609895
-
Mayers, J. R. et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 353, 1161–1165 (2016)
-
(2016)
Science
, vol.353
, pp. 1161-1165
-
-
Mayers, J.R.1
-
110
-
-
85023194321
-
DNA methylation markers for diagnosis and prognosis of common cancers
-
COI: 1:CAS:528:DC%2BC2sXhtVKhsrbN, PID: 28652331
-
Hao, X. et al. DNA methylation markers for diagnosis and prognosis of common cancers. Proc. Natl Acad. Sci. USA 114, 7414–7419 (2017)
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. 7414-7419
-
-
Hao, X.1
-
111
-
-
80053144962
-
A decade of exploring the cancer epigenome — biological and translational implications
-
COI: 1:CAS:528:DC%2BC3MXht1ajur7K, PID: 21941284
-
Baylin, S. B. & Jones, P. A. A decade of exploring the cancer epigenome — biological and translational implications. Nat. Rev. Cancer 11, 726–734 (2011)
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
Jones, P.A.2
-
112
-
-
84963971785
-
Methylated circulating tumor DNA in blood: power in cancer prognosis and response
-
COI: 1:CAS:528:DC%2BC2sXivV2mtrc%3D, PID: 26764421
-
Warton, K., Mahon, K. L. & Samimi, G. Methylated circulating tumor DNA in blood: power in cancer prognosis and response. Endocr. Relat. Cancer 23, R157–R171 (2016)
-
(2016)
Endocr. Relat. Cancer
, vol.23
, pp. R157-R171
-
-
Warton, K.1
Mahon, K.L.2
Samimi, G.3
-
113
-
-
85038930437
-
Methylation patterns in serum DNA for early identification of disseminated breast cancer
-
PID: 29268762
-
Widschwendter, M. et al. Methylation patterns in serum DNA for early identification of disseminated breast cancer. Genome Med. 9, 115 (2017)
-
(2017)
Genome Med.
, vol.9
-
-
Widschwendter, M.1
-
114
-
-
85038919999
-
The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer
-
PID: 29268796
-
Widschwendter, M. et al. The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer. Genome Med. 9, 116 (2017)
-
(2017)
Genome Med.
, vol.9
-
-
Widschwendter, M.1
-
115
-
-
70249147655
-
Sensitive digital quantification of DNA methylation in clinical samples
-
PID: 19684580
-
Li, M. et al. Sensitive digital quantification of DNA methylation in clinical samples. Nat. Biotechnol. 27, 858–863 (2009)
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 858-863
-
-
Li, M.1
-
116
-
-
85014528183
-
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
-
COI: 1:CAS:528:DC%2BC2sXltVWgtbw%3D, PID: 28263317
-
Guo, S. et al. Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat. Genet. 49, 635–642 (2017)
-
(2017)
Nat. Genet.
, vol.49
, pp. 635-642
-
-
Guo, S.1
-
117
-
-
84962407100
-
Identification of tissue-specific cell death using methylation patterns of circulating DNA
-
COI: 1:CAS:528:DC%2BC28XktFemsLY%3D, PID: 26976580
-
Lehmann-Werman, R. et al. Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc. Natl Acad. Sci. USA 113, E1826–E1834 (2016)
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E1826-E1834
-
-
Lehmann-Werman, R.1
-
118
-
-
84944892942
-
Characterization of DNA methylation in circulating tumor cells
-
COI: 1:CAS:528:DC%2BC2MXhslymtbzM, PID: 26506390
-
Pixberg, C. F., Schulz, W. A., Stoecklein, N. H. & Neves, R. P. Characterization of DNA methylation in circulating tumor cells. Genes 6, 1053–1075 (2015)
-
(2015)
Genes
, vol.6
, pp. 1053-1075
-
-
Pixberg, C.F.1
Schulz, W.A.2
Stoecklein, N.H.3
Neves, R.P.4
-
119
-
-
85047802652
-
ESR1 methylation: a liquid biopsy-based epigenetic assay for the follow-up of patients with metastatic breast cancer receiving endocrine treatment
-
COI: 1:CAS:528:DC%2BC1cXks1ylsr4%3D, PID: 29284708
-
Mastoraki, S. et al. ESR1 methylation: a liquid biopsy-based epigenetic assay for the follow-up of patients with metastatic breast cancer receiving endocrine treatment. Clin. Cancer Res. 24, 1500–1510 (2018)
-
(2018)
Clin. Cancer Res.
, vol.24
, pp. 1500-1510
-
-
Mastoraki, S.1
-
120
-
-
85030630310
-
Single-cell epigenomics: recording the past and predicting the future
-
COI: 1:CAS:528:DC%2BC2sXhsF2jtLrK, PID: 28983045
-
Kelsey, G., Stegle, O. & Reik, W. Single-cell epigenomics: recording the past and predicting the future. Science 358, 69–75 (2017)
-
(2017)
Science
, vol.358
, pp. 69-75
-
-
Kelsey, G.1
Stegle, O.2
Reik, W.3
-
121
-
-
84901049709
-
Noninvasive in vivo monitoring of tissue-specific global gene expression in humans
-
COI: 1:CAS:528:DC%2BC2cXnsVagsbw%3D, PID: 24799715
-
Koh, W. et al. Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. Proc. Natl Acad. Sci. USA 111, 7361–7366 (2014)
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 7361-7366
-
-
Koh, W.1
-
122
-
-
84903731165
-
Maternal plasma RNA sequencing for genome-wide transcriptomic profiling and identification of pregnancy-associated transcripts
-
COI: 1:CAS:528:DC%2BC2cXhtFWhu7fE, PID: 24740362
-
Tsui, N. B. et al. Maternal plasma RNA sequencing for genome-wide transcriptomic profiling and identification of pregnancy-associated transcripts. Clin. Chem. 60, 954–962 (2014)
-
(2014)
Clin. Chem.
, vol.60
, pp. 954-962
-
-
Tsui, N.B.1
-
123
-
-
0036282415
-
Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells
-
COI: 1:CAS:528:DC%2BD38XislOqsb8%3D, PID: 11889075
-
Silva, J. M. et al. Detection of epithelial tumour RNA in the plasma of colon cancer patients is associated with advanced stages and circulating tumour cells. Gut 50, 530–534 (2002)
-
(2002)
Gut
, vol.50
, pp. 530-534
-
-
Silva, J.M.1
-
124
-
-
34848836095
-
Genomic profiling of circulating plasma RNA for the analysis of cancer
-
COI: 1:CAS:528:DC%2BD2sXhtFKnu77I, PID: 17717129
-
Collado, M. et al. Genomic profiling of circulating plasma RNA for the analysis of cancer. Clin. Chem. 53, 1860–1863 (2007)
-
(2007)
Clin. Chem.
, vol.53
, pp. 1860-1863
-
-
Collado, M.1
-
125
-
-
53349177819
-
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
-
COI: 1:CAS:528:DC%2BD1cXhtF2hsbbE, PID: 18766170
-
Chen, X. et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997–1006 (2008)
-
(2008)
Cell Res.
, vol.18
, pp. 997-1006
-
-
Chen, X.1
-
126
-
-
84961219031
-
Circulating cancer biomarkers: the macro-revolution of the micro-RNA
-
PID: 27077096
-
Montani, F. & Bianchi, F. Circulating cancer biomarkers: the macro-revolution of the micro-RNA. EBioMedicine 5, 4–6 (2016)
-
(2016)
EBioMedicine
, vol.5
, pp. 4-6
-
-
Montani, F.1
Bianchi, F.2
-
127
-
-
0037447089
-
mRNA of placental origin is readily detectable in maternal plasma
-
COI: 1:CAS:528:DC%2BD3sXjt12nsLg%3D, PID: 12644709
-
Ng, E. K. O. et al. mRNA of placental origin is readily detectable in maternal plasma. Proc. Natl Acad. Sci. USA 100, 4748–4753 (2003)
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4748-4753
-
-
Ng, E.K.O.1
-
128
-
-
84929845363
-
miR-Test: a blood test for lung cancer early detection
-
PID: 25794889
-
Montani, F. et al. miR-Test: a blood test for lung cancer early detection. J. Natl. Cancer Inst. 107, djv063 (2015)
-
(2015)
J. Natl. Cancer Inst.
, vol.107
, pp. djv063
-
-
Montani, F.1
-
129
-
-
84897015133
-
Clinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: a correlative MILD trial study
-
PID: 24419137
-
Sozzi, G. et al. Clinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: a correlative MILD trial study. J. Clin. Oncol. 32, 768–773 (2014)
-
(2014)
J. Clin. Oncol.
, vol.32
, pp. 768-773
-
-
Sozzi, G.1
-
130
-
-
79961025970
-
MicroRNAs in body fluids-the mix of hormones and biomarkers
-
COI: 1:CAS:528:DC%2BC3MXpsFKgsrY%3D, PID: 21647195
-
Cortez, M. A. et al. MicroRNAs in body fluids-the mix of hormones and biomarkers. Nat. Rev. Clin. Oncol. 8, 467–477 (2011)
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 467-477
-
-
Cortez, M.A.1
-
131
-
-
84946576277
-
Data normalization strategies for microRNA quantification
-
COI: 1:CAS:528:DC%2BC28XjtVSnsbY%3D, PID: 26408530
-
Schwarzenbach, H., da Silva, A. M., Calin, G. & Pantel, K. Data normalization strategies for microRNA quantification. Clin. Chem. 61, 1333–1342 (2015)
-
(2015)
Clin. Chem.
, vol.61
, pp. 1333-1342
-
-
Schwarzenbach, H.1
da Silva, A.M.2
Calin, G.3
Pantel, K.4
-
132
-
-
84896703318
-
Clinical relevance of circulating cell-free microRNAs in cancer
-
COI: 1:CAS:528:DC%2BC2cXhs1yktb8%3D, PID: 24492836
-
Schwarzenbach, H., Nishida, N., Calin, G. A. & Pantel, K. Clinical relevance of circulating cell-free microRNAs in cancer. Nat. Rev. Clin. Oncol. 11, 145–156 (2014)
-
(2014)
Nat. Rev. Clin. Oncol.
, vol.11
, pp. 145-156
-
-
Schwarzenbach, H.1
Nishida, N.2
Calin, G.A.3
Pantel, K.4
-
133
-
-
85008146360
-
Extracellular vesicles: unique intercellular delivery vehicles
-
COI: 1:CAS:528:DC%2BC28XhvFOju73J, PID: 27979573
-
Maas, S. L., Breakefield, X. O. & Weaver, A. M. Extracellular vesicles: unique intercellular delivery vehicles. Trends Cell. Biol. 27, 172–188 (2017)
-
(2017)
Trends Cell. Biol.
, vol.27
, pp. 172-188
-
-
Maas, S.L.1
Breakefield, X.O.2
Weaver, A.M.3
-
134
-
-
84860858416
-
Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
-
COI: 1:CAS:528:DC%2BC38XnslSjt7c%3D, PID: 22503788
-
Vlassov, A. V., Magdaleno, S., Setterquist, R. & Conrad, R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta 1820, 940–948 (2012)
-
(2012)
Biochim. Biophys. Acta
, vol.1820
, pp. 940-948
-
-
Vlassov, A.V.1
Magdaleno, S.2
Setterquist, R.3
Conrad, R.4
-
135
-
-
84955275191
-
Plasma extracellular RNA profiles in healthy and cancer patients
-
COI: 1:CAS:528:DC%2BC28Xht1ertrY%3D, PID: 26786760
-
Yuan, T. Z. et al. Plasma extracellular RNA profiles in healthy and cancer patients. Sci. Rep. 6, 19413 (2016)
-
(2016)
Sci. Rep.
, vol.6
-
-
Yuan, T.Z.1
-
136
-
-
84867602816
-
Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer
-
COI: 1:CAS:528:DC%2BC38Xhs1WhtbrP, PID: 23091600
-
Khan, S. et al. Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLOS ONE 7, e46737 (2012)
-
(2012)
PLOS ONE
, vol.7
-
-
Khan, S.1
-
137
-
-
84936980504
-
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
-
COI: 1:CAS:528:DC%2BC2MXht1entr7E, PID: 26106858
-
Melo, S. A. et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523, 177–182 (2015)
-
(2015)
Nature
, vol.523
, pp. 177-182
-
-
Melo, S.A.1
-
138
-
-
79959201069
-
Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage
-
COI: 1:CAS:528:DC%2BC3MXovFOgsr8%3D, PID: 21601258
-
Rupp, A. K. et al. Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. Gynecol. Oncol. 122, 437–446 (2011)
-
(2011)
Gynecol. Oncol.
, vol.122
, pp. 437-446
-
-
Rupp, A.K.1
-
139
-
-
84947723880
-
Tumour exosome integrins determine organotropic metastasis
-
COI: 1:CAS:528:DC%2BC2MXhslOrtb7P, PID: 26524530
-
Hoshino, A. et al. Tumour exosome integrins determine organotropic metastasis. Nature 527, 329–335 (2015)
-
(2015)
Nature
, vol.527
, pp. 329-335
-
-
Hoshino, A.1
-
140
-
-
85015629030
-
Pre-metastatic niches: organ-specific homes for metastases
-
COI: 1:CAS:528:DC%2BC2sXkt1Ont7w%3D, PID: 28303905
-
Peinado, H. et al. Pre-metastatic niches: organ-specific homes for metastases. Nat. Rev. Cancer 17, 302–317 (2017)
-
(2017)
Nat. Rev. Cancer
, vol.17
, pp. 302-317
-
-
Peinado, H.1
-
141
-
-
84901842265
-
Double-stranded DNA in exosomes: a novel biomarker in cancer detection
-
COI: 1:CAS:528:DC%2BC2cXmtVCqtb8%3D, PID: 4042169
-
Thakur, B. K. et al. Double-stranded DNA in exosomes: a novel biomarker in cancer detection. Cell Res. 24, 766–769 (2014)
-
(2014)
Cell Res.
, vol.24
, pp. 766-769
-
-
Thakur, B.K.1
-
142
-
-
85019060081
-
High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients
-
COI: 1:STN:280:DC%2BC1c7nsVKjsA%3D%3D, PID: 28104621
-
Allenson, K. et al. High prevalence of mutant KRAS in circulating exosome-derived DNA from early-stage pancreatic cancer patients. Ann. Oncol. 28, 741–747 (2017)
-
(2017)
Ann. Oncol.
, vol.28
, pp. 741-747
-
-
Allenson, K.1
-
143
-
-
84964597652
-
The biology and function of exosomes in cancer
-
PID: 27035812
-
Kalluri, R. The biology and function of exosomes in cancer. J. Clin. Invest. 126, 1208–1215 (2016)
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 1208-1215
-
-
Kalluri, R.1
-
144
-
-
84900307606
-
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
-
COI: 1:CAS:528:DC%2BC2cXmsVKksrs%3D, PID: 24752081
-
Im, H. et al. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat. Biotechnol. 32, 490–495 (2014)
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 490-495
-
-
Im, H.1
-
145
-
-
84962733931
-
Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake
-
COI: 1:CAS:528:DC%2BC28XlvFCmurk%3D, PID: 27053351
-
Abels, E. R. & Breakefield, X. O. Introduction to extracellular vesicles: biogenesis, RNA cargo selection, content, release, and uptake. Cell. Mol. Neurobiol. 36, 301–312 (2016)
-
(2016)
Cell. Mol. Neurobiol.
, vol.36
, pp. 301-312
-
-
Abels, E.R.1
Breakefield, X.O.2
-
146
-
-
79953269443
-
Tumor markers in clinical practice: general principles and guidelines
-
COI: 1:CAS:528:DC%2BC3cXht1CntrbM, PID: 20668599
-
Sharma, S. Tumor markers in clinical practice: general principles and guidelines. Indian J. Med. Paediatr. Oncol. 30, 1–8 (2009)
-
(2009)
Indian J. Med. Paediatr. Oncol.
, vol.30
, pp. 1-8
-
-
Sharma, S.1
-
147
-
-
84954376354
-
Prostate cancer
-
Attard, G. et al. Prostate cancer. Lancet 387, 70–82 (2016)
-
(2016)
Lancet
, vol.387
, pp. 70-82
-
-
Attard, G.1
-
148
-
-
0029906687
-
Clinical use of tumor markers based on outcome analysis
-
Aziz, D. C. Clinical use of tumor markers based on outcome analysis. Lab. Med. 27, 817–821 (1996)
-
(1996)
Lab. Med.
, vol.27
, pp. 817-821
-
-
Aziz, D.C.1
-
149
-
-
84988517517
-
Mass-spectrometric exploration of proteome structure and function
-
COI: 1:CAS:528:DC%2BC28XhsFajsr3O, PID: 27629641
-
Aebersold, R. & Mann, M. Mass-spectrometric exploration of proteome structure and function. Nature 537, 347–355 (2016)
-
(2016)
Nature
, vol.537
, pp. 347-355
-
-
Aebersold, R.1
Mann, M.2
-
150
-
-
84953285021
-
Advances in mass spectrometry-based clinical biomarker discovery
-
Crutchfield, C. A., Thomas, S. N., Sokoll, L. J. & Chan, D. W. Advances in mass spectrometry-based clinical biomarker discovery. Clin. Proteom. 13, 1 (2016)
-
(2016)
Clin. Proteom.
, vol.13
-
-
Crutchfield, C.A.1
Thomas, S.N.2
Sokoll, L.J.3
Chan, D.W.4
-
151
-
-
85008690126
-
Scalable whole-genome single-cell library preparation without preamplification
-
COI: 1:CAS:528:DC%2BC2sXlsFGgtg%3D%3D, PID: 28068316
-
Zahn, H. et al. Scalable whole-genome single-cell library preparation without preamplification. Nat. Methods 14, 167–173 (2017)
-
(2017)
Nat. Methods
, vol.14
, pp. 167-173
-
-
Zahn, H.1
-
152
-
-
85010982914
-
Sequencing thousands of single-cell genomes with combinatorial indexing
-
COI: 1:CAS:528:DC%2BC2sXhvV2hsrc%3D, PID: 28135258
-
Vitak, S. A. et al. Sequencing thousands of single-cell genomes with combinatorial indexing. Nat. Methods 14, 302–308 (2017)
-
(2017)
Nat. Methods
, vol.14
, pp. 302-308
-
-
Vitak, S.A.1
-
153
-
-
85010966978
-
An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma
-
COI: 1:CAS:528:DC%2BC2sXhtFars7Y%3D, PID: 28096363
-
Kalinich, M. et al. An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma. Proc. Natl Acad. Sci. USA 114, 1123–1128 (2017)
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. 1123-1128
-
-
Kalinich, M.1
-
154
-
-
84860571431
-
EPISPOT assay: detection of viable DTCs/CTCs in solid tumor patients
-
PID: 22527495
-
Alix-Panabieres, C. EPISPOT assay: detection of viable DTCs/CTCs in solid tumor patients. Recent Results Cancer Res. 195, 69–76 (2012)
-
(2012)
Recent Results Cancer Res.
, vol.195
, pp. 69-76
-
-
Alix-Panabieres, C.1
-
155
-
-
84963632004
-
Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
-
PID: 27091476
-
Clark, S. J., Lee, H. J., Smallwood, S. A., Kelsey, G. & Reik, W. Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity. Genome Biol. 17, 72 (2016)
-
(2016)
Genome Biol.
, vol.17
-
-
Clark, S.J.1
Lee, H.J.2
Smallwood, S.A.3
Kelsey, G.4
Reik, W.5
-
156
-
-
84947128466
-
Liquid biopsy in cancer patients: advances in capturing viable CTCs for functional studies using the EPISPOT assay
-
PID: 26390240
-
Alix-Panabieres, C. & Pantel, K. Liquid biopsy in cancer patients: advances in capturing viable CTCs for functional studies using the EPISPOT assay. Expert Rev. Mol. Diagn. 15, 1411–1417 (2015)
-
(2015)
Expert Rev. Mol. Diagn.
, vol.15
, pp. 1411-1417
-
-
Alix-Panabieres, C.1
Pantel, K.2
-
157
-
-
84880270290
-
Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
-
COI: 1:CAS:528:DC%2BC3sXmt1WisLw%3D, PID: 23609047
-
Baccelli, I. et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat. Biotechnol. 31, 539–544 (2013)
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 539-544
-
-
Baccelli, I.1
-
158
-
-
84905819148
-
Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer
-
COI: 1:CAS:528:DC%2BC2cXovFCnsrs%3D, PID: 24880617
-
Hodgkinson, C. L. et al. Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer. Nat. Med. 20, 897–903 (2014)
-
(2014)
Nat. Med.
, vol.20
, pp. 897-903
-
-
Hodgkinson, C.L.1
-
159
-
-
84928698890
-
Establishment and characterization of a cell line from human circulating colon cancer cells
-
COI: 1:CAS:528:DC%2BC2MXjsF2hsb4%3D, PID: 25592149
-
Cayrefourcq, L. et al. Establishment and characterization of a cell line from human circulating colon cancer cells. Cancer Res. 75, 892–901 (2015)
-
(2015)
Cancer Res.
, vol.75
, pp. 892-901
-
-
Cayrefourcq, L.1
-
160
-
-
84877865227
-
Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing
-
COI: 1:CAS:528:DC%2BC3sXnsFejs7Y%3D, PID: 23471846
-
Heitzer, E. et al. Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res. 73, 2965–2975 (2013)
-
(2013)
Cancer Res.
, vol.73
, pp. 2965-2975
-
-
Heitzer, E.1
-
161
-
-
84893637270
-
One mouse, one patient paradigm: new avatars of personalized cancer therapy
-
COI: 1:CAS:528:DC%2BC3sXhslehsrbF, PID: 24157811
-
Malaney, P., Nicosia, S. V. & Dave, V. One mouse, one patient paradigm: new avatars of personalized cancer therapy. Cancer Lett. 344, 1–12 (2014)
-
(2014)
Cancer Lett.
, vol.344
, pp. 1-12
-
-
Malaney, P.1
Nicosia, S.V.2
Dave, V.3
-
162
-
-
85028357956
-
Circulating tumor cells and CDX models as a tool for preclinical drug development
-
COI: 1:CAS:528:DC%2BC1cXitVOqurvI, PID: 28904884
-
Lallo, A., Schenk, M. W., Frese, K. K., Blackhall, F. & Dive, C. Circulating tumor cells and CDX models as a tool for preclinical drug development. Transl Lung Cancer Res. 6, 397–408 (2017)
-
(2017)
Transl Lung Cancer Res.
, vol.6
, pp. 397-408
-
-
Lallo, A.1
Schenk, M.W.2
Frese, K.K.3
Blackhall, F.4
Dive, C.5
-
163
-
-
84995960806
-
Genomic copy number profiling using circulating free tumor DNA highlights heterogeneity in neuroblastoma
-
COI: 1:CAS:528:DC%2BC28XhvVCqurzL, PID: 27440268
-
Chicard, M. et al. Genomic copy number profiling using circulating free tumor DNA highlights heterogeneity in neuroblastoma. Clin. Cancer Res. 22, 5564–5573 (2016)
-
(2016)
Clin. Cancer Res.
, vol.22
, pp. 5564-5573
-
-
Chicard, M.1
-
164
-
-
40449127919
-
Detection and characterization of placental MicroRNAs in maternal plasma
-
COI: 1:CAS:528:DC%2BD1cXivVansrc%3D, PID: 18218722
-
Chim, S. S. C. et al. Detection and characterization of placental MicroRNAs in maternal plasma. Clin. Chem. 54, 482–490 (2008)
-
(2008)
Clin. Chem.
, vol.54
, pp. 482-490
-
-
Chim, S.S.C.1
-
165
-
-
63149121152
-
Circulating microRNAs, potential biomarkers for drug-induced liver injury
-
COI: 1:CAS:528:DC%2BD1MXjslyhsL4%3D, PID: 19246379
-
Wang, K. et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc. Natl Acad. Sci. USA 106, 4402–4407 (2009)
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4402-4407
-
-
Wang, K.1
-
166
-
-
84943375035
-
Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments
-
COI: 1:CAS:528:DC%2BC2MXhsFamsL3F, PID: 26392541, this study, the tissue of origin of cell-free circulating DNA is tracked using methylation deconvolution different cohorts
-
Sun, K. et al. Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments. Proc. Natl Acad. Sci. USA 112, E5503–E5512 (2015). In this study, the tissue of origin of circulating cell-free DNA is tracked using methylation deconvolution in different cohorts
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. E5503-E5512
-
-
Sun, K.1
-
167
-
-
84994715747
-
Cell-free DNA in maternal plasma and serum: a comparison of quantity, quality and tissue origin using genomic and epigenomic approaches
-
COI: 1:CAS:528:DC%2BC28XhsFSks73L, PID: 27620950
-
Wong, F. C. et al. Cell-free DNA in maternal plasma and serum: a comparison of quantity, quality and tissue origin using genomic and epigenomic approaches. Clin. Biochem. 49, 1379–1386 (2016)
-
(2016)
Clin. Biochem.
, vol.49
, pp. 1379-1386
-
-
Wong, F.C.1
-
168
-
-
85030751484
-
DNA of erythroid origin is present in human plasma and informs the types of anemia
-
COI: 1:CAS:528:DC%2BC1cXjtlehsLw%3D, PID: 28784691
-
Lam, W. K. J. et al. DNA of erythroid origin is present in human plasma and informs the types of anemia. Clin. Chem. 63, 1614–1623 (2017)
-
(2017)
Clin. Chem.
, vol.63
, pp. 1614-1623
-
-
Lam, W.K.J.1
-
169
-
-
0036177799
-
Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation
-
COI: 1:CAS:528:DC%2BD38XitVeku7s%3D, PID: 11861434
-
Lui, Y. N. Y. N. et al. Predominant hematopoietic origin of cell-free DNA in plasma and serum after sex-mismatched bone marrow transplantation. Clin. Chem. 48, 421–427 (2002)
-
(2002)
Clin. Chem.
, vol.48
, pp. 421-427
-
-
Lui, Y.N.Y.N.1
-
170
-
-
85027881566
-
Facile single-stranded DNA sequencing of human plasma DNA via thermostable group II intron reverse transcriptase template switching
-
PID: 28827600
-
Wu, D. C. & Lambowitz, A. M. Facile single-stranded DNA sequencing of human plasma DNA via thermostable group II intron reverse transcriptase template switching. Sci. Rep. 7, 8421 (2017)
-
(2017)
Sci. Rep.
, vol.7
-
-
Wu, D.C.1
Lambowitz, A.M.2
-
171
-
-
84988661380
-
Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape
-
COI: 1:CAS:528:DC%2BC28XhsFOntLbN, PID: 27644321
-
Mohme, M., Riethdorf, S. & Pantel, K. Circulating and disseminated tumour cells — mechanisms of immune surveillance and escape. Nat. Rev. Clin. Oncol. 14, 155–167 (2017)
-
(2017)
Nat. Rev. Clin. Oncol.
, vol.14
, pp. 155-167
-
-
Mohme, M.1
Riethdorf, S.2
Pantel, K.3
-
172
-
-
84945475723
-
Frequent expression of PD-L1 on circulating breast cancer cells
-
COI: 1:CAS:528:DC%2BC2MXhtVekt7jF, PID: 26093818
-
Mazel, M. et al. Frequent expression of PD-L1 on circulating breast cancer cells. Mol. Oncol. 9, 1773–1782 (2015)
-
(2015)
Mol. Oncol.
, vol.9
, pp. 1773-1782
-
-
Mazel, M.1
-
173
-
-
85044122671
-
Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles
-
PID: 29532035
-
Ricklefs, F. L. et al. Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles. Sci. Adv. 4, eaar2766 (2018)
-
(2018)
Sci. Adv.
, vol.4
-
-
Ricklefs, F.L.1
-
174
-
-
85003475383
-
Predictive biomarkers for checkpoint inhibitor-based immunotherapy
-
COI: 1:CAS:528:DC%2BC28XhvF2gsL7M, PID: 27924752
-
Gibney, G. T., Weiner, L. M. & Atkins, M. B. Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Lancet Oncol. 17, E542–E551 (2016)
-
(2016)
Lancet Oncol.
, vol.17
, pp. E542-E551
-
-
Gibney, G.T.1
Weiner, L.M.2
Atkins, M.B.3
-
175
-
-
85032026566
-
Hypermutated circulating tumor DNA: correlation with response to checkpoint inhibitor-based immunotherapy
-
COI: 1:CAS:528:DC%2BC2sXhsFOls7jK, PID: 28972084
-
Khagi, Y. et al. Hypermutated circulating tumor DNA: correlation with response to checkpoint inhibitor-based immunotherapy. Clin. Cancer Res. 23, 5729–5736 (2017)
-
(2017)
Clin. Cancer Res.
, vol.23
, pp. 5729-5736
-
-
Khagi, Y.1
-
176
-
-
85049969565
-
Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer
-
Kim, S. T. et al. Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer. Nat. Med. 10.1038/s41591-018-0101-z (2018)
-
(2018)
Nat. Med.
-
-
Kim, S.T.1
-
177
-
-
85052511307
-
Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab
-
COI: 1:CAS:528:DC%2BC1cXhsVGrsLjF, PID: 30082870
-
Gandara, D. R. et al. Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab. Nat. Med. 24, 1441–1448 (2018)
-
(2018)
Nat. Med.
, vol.24
, pp. 1441-1448
-
-
Gandara, D.R.1
-
178
-
-
85029898885
-
Diagnostic value of CA19.9, circulating tumour DNA and circulating tumour cells in patients with solid pancreatic tumours
-
COI: 1:CAS:528:DC%2BC2sXht1yitrvL, PID: 28772284
-
Sefrioui, D. et al. Diagnostic value of CA19.9, circulating tumour DNA and circulating tumour cells in patients with solid pancreatic tumours. Br. J. Cancer 117, 1017–1025 (2017)
-
(2017)
Br. J. Cancer
, vol.117
, pp. 1017-1025
-
-
Sefrioui, D.1
-
179
-
-
85042295234
-
Cancer detection: Seeking signals in blood
-
PID: 29472467
-
Kalinich, M. & Haber, D. A. Cancer detection: Seeking signals in blood. Science 359, 866–867 (2018)
-
(2018)
Science
, vol.359
, pp. 866-867
-
-
Kalinich, M.1
Haber, D.A.2
-
180
-
-
85045673878
-
Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy
-
PID: 29557778
-
Springer, S. U. et al. Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. eLife 7, e32143 (2018)
-
(2018)
eLife
, vol.7
-
-
Springer, S.U.1
-
181
-
-
85044537049
-
Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers
-
PID: 29563323
-
Wang, Y. et al. Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Sci. Transl Med. 10, eaap8793 (2018)
-
(2018)
Sci. Transl. Med.
, vol.10
-
-
Wang, Y.1
-
182
-
-
84960984309
-
Deep learning in label-free cell classification
-
COI: 1:CAS:528:DC%2BC28XktFKmtLY%3D, PID: 26975219
-
Chen, C. L. et al. Deep learning in label-free cell classification. Sci. Rep. 6, 21471 (2016)
-
(2016)
Sci. Rep.
, vol.6
-
-
Chen, C.L.1
-
183
-
-
85036524079
-
Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer
-
PID: 29087294
-
Elias, K. M. et al. Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer. eLife 6, e28932 (2017)
-
(2017)
eLife
, vol.6
-
-
Elias, K.M.1
-
184
-
-
85006839848
-
DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations
-
PID: 28155641
-
Yuan, Y. et al. DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations. BMC Bioinformatics 17, 476 (2016)
-
(2016)
BMC Bioinformatics
, vol.17
-
-
Yuan, Y.1
-
185
-
-
85016166382
-
CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA
-
PID: 28335812, This study exploits the diagtic potential of genome-wide DNA methylation data from cfDNA to determine not only the presence but also the location of tumours. CancerLocator simultaneously infers the proportions and the tissue of origin of tumour-derived cell-free DNA a blood sample
-
Kang, S. L. et al. CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA. Genome Biol. 18, 53 (2017). This study exploits the diagnostic potential of genome-wide DNA methylation data from cfDNA to determine not only the presence but also the location of tumours. CancerLocator simultaneously infers the proportions and the tissue of origin of tumour-derived cell-free DNA in a blood sample
-
(2017)
Genome Biol.
, vol.18
-
-
Kang, S.L.1
-
186
-
-
85024487501
-
SecureML: A System for Scalable Privacy-Preserving Machine Learning
-
Mohassel, P. SecureML: a system for scalable privacy-preserving machine learning. IEEE 10.1109/SP.2017.12 (2017)
-
(2017)
IEEE
-
-
Mohassel, P.1
|