Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study

PLoS Medicine

Volumn 13, Issue 12, 2016, Pages

  Parkinson, Christine A ^a,b,c,d   Gale, Davina ^a,d   Piskorz, Anna M ^a,d   Biggs, Heather ^a,b,d   Hodgkin, Charlotte ^a,d   Addley, Helen ^c,d   Freeman, Sue ^c,d   Moyle, Penelope ^c,d   Sala, Evis ^c,e   Sayal, Karen ^a   Hosking, Karen ^a,b,d   Gounaris, Ioannis ^a,d   Jimenez Linan, Mercedes ^c,d   Earl, Helena M ^a,b,c,d   Qian, Wendi ^c,d   Rosenfeld, Nitzan ^a,d   Brenton, James D ^a,b,c,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NIHR Cambridge Biomedical Research Centre   (United Kingdom)

^c CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^e MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CA 125 ANTIGEN; CIRCULATING TUMOUR DNA; DNA; PLATINUM; PROTEIN P53; UNCLASSIFIED DRUG; TP53 PROTEIN, HUMAN; TUMOR MARKER;

ADULT; AGED; ALLELE; ARTICLE; BLOOD ANALYSIS; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER RECURRENCE; CANCER STAGING; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXPLORATORY RESEARCH; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOASSAY; MULTIPLE CYCLE TREATMENT; MUTANT ALLELE FRACTION; OVARY CARCINOMA; POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; TREATMENT RESPONSE; VALIDATION STUDY; VERY ELDERLY; VOLUMETRY; BLOOD; CARCINOMA; GENETICS; METABOLISM; MIDDLE AGED; MUTATION; OVARY TUMOR; TUMOR EMBOLISM;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CARCINOMA; DNA, NEOPLASM; FEMALE; HUMANS; MIDDLE AGED; MUTATION; NEOPLASTIC CELLS, CIRCULATING; OVARIAN NEOPLASMS; RETROSPECTIVE STUDIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85007602110     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1002198     Document Type: Article

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