Resistance to Anti-EGFR therapy in colorectal cancer: From heterogeneity to convergent evolution

Cancer Discovery

Volumn 4, Issue 11, 2014, Pages 1269-1280

  Misale, Sandra ^a,b   Di Nicolantonio, Federica ^a,b   Sartore Bianchi, Andrea ^c   Siena, Salvatore ^c   Bardelli, Alberto ^a,b,d  

^a UNIVERSITY OF TURIN   (Italy)

^b CANDIOLO CANCER INSTITUTE   (Italy)

^c OSPEDALE NIGUARDA CA GRANDA   (Italy)

^d FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4, 5 BISPHOSPHATE 3 KINASE; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY;

ADENOMA; CANCER RESISTANCE; COLORECTAL CANCER; CONVERGENT EVOLUTION; GENE AMPLIFICATION; GENE DOSAGE; GENE MUTATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; ONCOGENE K RAS; ONCOGENE N RAS; ONCOGENE RAS; OVERLAPPING GENE; PHASE 3 CLINICAL TRIAL (TOPIC); POINT MUTATION; PYROSEQUENCING; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; ANIMAL; ANTAGONISTS AND INHIBITORS; COLORECTAL NEOPLASMS; DRUG RESISTANCE; GENETICS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; COLORECTAL NEOPLASMS; DRUG RESISTANCE, NEOPLASM; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84908431348     PISSN: 21598274     EISSN: 21598290     Source Type: Journal    
DOI: 10.1158/2159-8290.CD-14-0462     Document Type: Review

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