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Volumn 36, Issue 3, 2016, Pages 301-312

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake

Author keywords

Biogenesis; Cargo selection; Exosomes; Extracellular vesicles; Microvesicles; RNA

Indexed keywords

FLUORESCENT DYE; LIPID; NUCLEIC ACID; RNA;

EID: 84962733931     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-016-0366-z     Document Type: Editorial
Times cited : (1221)

References (135)
  • 1
    • 84888432401 scopus 로고    scopus 로고
    • Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin
    • COI: 1:CAS:528:DC%2BC3sXhslyqu77P, PID: 24239351
    • Abrami L, Brandi L, Moayeri M et al (2013) Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin. Cell Rep 5:986–996. doi:10.1016/j.celrep.2013.10.019
    • (2013) Cell Rep , vol.5 , pp. 986-996
    • Abrami, L.1    Brandi, L.2    Moayeri, M.3
  • 2
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • PID: 23456661
    • Akers JC, Gonda D, Kim R et al (2013) Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol 113:1–11
    • (2013) J Neurooncol , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3
  • 3
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • COI: 1:CAS:528:DC%2BD1cXltl2isLw%3D, PID: 18425114
    • Al-Nedawi K, Meehan B, Micallef J et al (2008) Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10:619–624. doi:10.1038/ncb1725
    • (2008) Nat Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3
  • 4
    • 33846508011 scopus 로고    scopus 로고
    • A new role of diacylglycerol kinase α on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes
    • COI: 1:CAS:528:DC%2BD2sXhtlaqs7k%3D, PID: 16989932
    • Alonso R, Mazzeo C, Mérida I, Izquierdo M (2007) A new role of diacylglycerol kinase α on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes. Biochimie 89:213–221. doi:10.1016/j.biochi.2006.07.018
    • (2007) Biochimie , vol.89 , pp. 213-221
    • Alonso, R.1    Mazzeo, C.2    Mérida, I.3    Izquierdo, M.4
  • 5
    • 79958796052 scopus 로고    scopus 로고
    • Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes
    • COI: 1:CAS:528:DC%2BC3MXnsVShtb8%3D, PID: 21252909
    • Alonso R, Mazzeo C, Rodriguez MC et al (2011) Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes. Cell Death Differ 18:1161–1173. doi:10.1038/cdd.2010.184
    • (2011) Cell Death Differ , vol.18 , pp. 1161-1173
    • Alonso, R.1    Mazzeo, C.2    Rodriguez, M.C.3
  • 6
    • 79953202200 scopus 로고    scopus 로고
    • Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    • COI: 1:CAS:528:DC%2BC3MXktVCjsro%3D, PID: 21383194
    • Arroyo JD, Chevillet JR, Kroh EM et al (2011) Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 108:5003–5008. doi:10.1073/pnas.1019055108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5003-5008
    • Arroyo, J.D.1    Chevillet, J.R.2    Kroh, E.M.3
  • 7
    • 84890312241 scopus 로고    scopus 로고
    • Heparin blocks transfer of extracellular vesicles between donor and recipient cells
    • COI: 1:CAS:528:DC%2BC3sXhtl2isrjI, PID: 24002181
    • Atai NA, Balaj L, Van Veen H et al (2013) Heparin blocks transfer of extracellular vesicles between donor and recipient cells. J Neurooncol 115:343–351. doi:10.1007/s11060-013-1235-y
    • (2013) J Neurooncol , vol.115 , pp. 343-351
    • Atai, N.A.1    Balaj, L.2    Van Veen, H.3
  • 8
    • 0036696804 scopus 로고    scopus 로고
    • ESCRT-III: an endosome-associated heterooligomeric protein complex required for MVB sorting
    • COI: 1:CAS:528:DC%2BD38Xmtl2it7c%3D, PID: 12194857
    • Babst M, Katzmann DJ, Estepa-Sabal EJ et al (2002) ESCRT-III: an endosome-associated heterooligomeric protein complex required for MVB sorting. Dev Cell 3:271–282. doi:10.1016/S1534-5807(02)00220-4
    • (2002) Dev Cell , vol.3 , pp. 271-282
    • Babst, M.1    Katzmann, D.J.2    Estepa-Sabal, E.J.3
  • 9
    • 0041488656 scopus 로고    scopus 로고
    • Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
    • COI: 1:CAS:528:DC%2BD3sXmt1Cru74%3D, PID: 12900395
    • Bache KG, Brech A, Mehlum A, Stenmark H (2003) Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol 162:435–442. doi:10.1083/jcb.200302131
    • (2003) J Cell Biol , vol.162 , pp. 435-442
    • Bache, K.G.1    Brech, A.2    Mehlum, A.3    Stenmark, H.4
  • 10
    • 84863206297 scopus 로고    scopus 로고
    • Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
    • COI: 1:CAS:528:DC%2BC38XnvVyqtr0%3D, PID: 22660413
    • Baietti MF, Zhang Z, Mortier E et al (2012) Syndecan–syntenin–ALIX regulates the biogenesis of exosomes. Nat Cell Biol 14:677–685
    • (2012) Nat Cell Biol , vol.14 , pp. 677-685
    • Baietti, M.F.1    Zhang, Z.2    Mortier, E.3
  • 11
    • 33645315758 scopus 로고    scopus 로고
    • Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes
    • COI: 1:CAS:528:DC%2BD28XivFShuro%3D, PID: 16283305
    • Baj-Krzyworzeka M, Szatanek R, Wȩglarczyk K et al (2006) Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol Immunother 55:808–818. doi:10.1007/s00262-005-0075-9
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 808-818
    • Baj-Krzyworzeka, M.1    Szatanek, R.2    Wȩglarczyk, K.3
  • 12
    • 79551608032 scopus 로고    scopus 로고
    • Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    • PID: 21285958
    • Balaj L, Lessard R, Dai L et al (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun 2:180. doi:10.1038/ncomms1180
    • (2011) Nat Commun , vol.2 , pp. 180
    • Balaj, L.1    Lessard, R.2    Dai, L.3
  • 13
    • 77449102731 scopus 로고    scopus 로고
    • Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages
    • PID: 19903899
    • Barrès C, Blanc L, Bette-Bobillo P et al (2010) Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages. Blood 115:696–705. doi:10.1182/blood-2009-07-231449
    • (2010) Blood , vol.115 , pp. 696-705
    • Barrès, C.1    Blanc, L.2    Bette-Bobillo, P.3
  • 14
    • 84891546204 scopus 로고    scopus 로고
    • Microvesicles and intercellular communication in the context of parasitism
    • PID: 24032108
    • Barteneva NS, Maltsev N, Vorobjev IA (2013) Microvesicles and intercellular communication in the context of parasitism. Front Cell Infect Microbiol 3:49. doi:10.3389/fcimb.2013.00049
    • (2013) Front Cell Infect Microbiol , vol.3 , pp. 49
    • Barteneva, N.S.1    Maltsev, N.2    Vorobjev, I.A.3
  • 15
    • 84878661930 scopus 로고    scopus 로고
    • Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions
    • PID: 23758897
    • Batagov AO, Kurochkin IV (2013) Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions. Biol Direct. doi:10.1186/1745-6150-8-12
    • (2013) Biol Direct
    • Batagov, A.O.1    Kurochkin, I.V.2
  • 16
    • 84874031607 scopus 로고    scopus 로고
    • Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS
    • COI: 1:CAS:528:DC%2BC3sXitFCgtLY%3D
    • Beckler M, Higginbotham JN, Franklin JL et al (2013) Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics 12:343–355. doi:10.1074/mcp.M112.022806
    • (2013) Mol Cell Proteomics , vol.12 , pp. 343-355
    • Beckler, M.1    Higginbotham, J.N.2    Franklin, J.L.3
  • 17
    • 84966548653 scopus 로고    scopus 로고
    • A novel exosome-mediated apical secretion pathway involving the V0-sector of the V-ATPase in C. elegans epidermal cells
    • Benedetto A, Liegeois S, Garnier J-M, et al (2006) A novel exosome-mediated apical secretion pathway involving the V0-sector of the V-ATPase in C. elegans epidermal cells. Eur Worm Meet
    • (2006) Eur Worm Meet
    • Benedetto, A.1    Liegeois, S.2    Garnier, J.-M.3
  • 18
    • 84869866108 scopus 로고    scopus 로고
    • Phospholipidomics reveals differences in glycerophosphoserine profiles of hypothermically stored red blood cells and microvesicles
    • COI: 1:CAS:528:DC%2BC3sXhtFSmtA%3D%3D, PID: 23123566
    • Bicalho B, Holovati JL, Acker JP (2013) Phospholipidomics reveals differences in glycerophosphoserine profiles of hypothermically stored red blood cells and microvesicles. Biochim Biophys Acta 1828:317–326. doi:10.1016/j.bbamem.2012.10.026
    • (2013) Biochim Biophys Acta , vol.1828 , pp. 317-326
    • Bicalho, B.1    Holovati, J.L.2    Acker, J.P.3
  • 19
    • 0035853688 scopus 로고    scopus 로고
    • TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes
    • COI: 1:CAS:528:DC%2BD3MXjtFyls7w%3D, PID: 11134028
    • Bishop N, Woodman P (2001) TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J Biol Chem 276:11735–11742. doi:10.1074/jbc.M009863200
    • (2001) J Biol Chem , vol.276 , pp. 11735-11742
    • Bishop, N.1    Woodman, P.2
  • 20
    • 84866364616 scopus 로고    scopus 로고
    • miR-1289 and “Zipcode”-like sequence enrich mrnas in microvesicles
    • Bolukbasi MF, Mizrak A, Ozdener GB et al (2012) miR-1289 and “Zipcode”-like sequence enrich mrnas in microvesicles. Mol Ther 1:e10
    • (2012) Mol Ther , vol.1 , pp. e10
    • Bolukbasi, M.F.1    Mizrak, A.2    Ozdener, G.B.3
  • 21
    • 84878667806 scopus 로고    scopus 로고
    • Distinct lipid compositions of two types of human prostasomes
    • COI: 1:CAS:528:DC%2BC3sXltVeltbg%3D, PID: 23404715
    • Brouwers JF, Aalberts M, Jansen JWA et al (2013) Distinct lipid compositions of two types of human prostasomes. Proteomics 13:1660–1666. doi:10.1002/pmic.201200348
    • (2013) Proteomics , vol.13 , pp. 1660-1666
    • Brouwers, J.F.1    Aalberts, M.2    Jansen, J.W.A.3
  • 22
    • 0032480781 scopus 로고    scopus 로고
    • Calcium induces phospholipid redistribution and microvesicle release in human erythrocyte membranes by independent pathways
    • COI: 1:CAS:528:DyaK1cXmsF2it7s%3D, PID: 9799499
    • Bucki R, Bachelot-Loza C, Zachowski A et al (1998) Calcium induces phospholipid redistribution and microvesicle release in human erythrocyte membranes by independent pathways. Biochemistry 37:15383–15391. doi:10.1021/bi9805238
    • (1998) Biochemistry , vol.37 , pp. 15383-15391
    • Bucki, R.1    Bachelot-Loza, C.2    Zachowski, A.3
  • 23
    • 80053208877 scopus 로고    scopus 로고
    • Proteolipidic composition of exosomes changes during reticulocyte maturation
    • COI: 1:CAS:528:DC%2BC3MXht1ajtbrO, PID: 21828046
    • Carayon K, Chaoui K, Ronzier E et al (2011) Proteolipidic composition of exosomes changes during reticulocyte maturation. J Biol Chem 286:34426–34439. doi:10.1074/jbc.M111.257444
    • (2011) J Biol Chem , vol.286 , pp. 34426-34439
    • Carayon, K.1    Chaoui, K.2    Ronzier, E.3
  • 24
    • 84905485531 scopus 로고    scopus 로고
    • Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine
    • Cheng L, Sun X, Scicluna BJ et al (2013) Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine. Kidney Int. doi:10.1038/ki.2013.502
    • (2013) Kidney Int
    • Cheng, L.1    Sun, X.2    Scicluna, B.J.3
  • 25
    • 84886387008 scopus 로고    scopus 로고
    • Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity
    • COI: 1:CAS:528:DC%2BC3sXhslejsLjJ, PID: 24101524
    • Christianson HC, Svensson KJ, van Kuppevelt TH et al (2013) Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci USA 110:17380–17385. doi:10.1073/pnas.1304266110
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17380-17385
    • Christianson, H.C.1    Svensson, K.J.2    van Kuppevelt, T.H.3
  • 26
    • 59249089695 scopus 로고    scopus 로고
    • Shedding microvesicles: artefacts no more
    • COI: 1:CAS:528:DC%2BD1MXhs1amt7Y%3D, PID: 19144520
    • Cocucci E, Racchetti G, Meldolesi J (2009) Shedding microvesicles: artefacts no more. Trends Cell Biol 19:43–51
    • (2009) Trends Cell Biol , vol.19 , pp. 43-51
    • Cocucci, E.1    Racchetti, G.2    Meldolesi, J.3
  • 27
    • 84890458696 scopus 로고    scopus 로고
    • Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    • COI: 1:CAS:528:DC%2BC2cXhtFyksLY%3D, PID: 24105262
    • Colombo M, Moita C, van Niel G et al (2013) Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J Cell Sci 126:5553–5565. doi:10.1242/jcs.128868
    • (2013) J Cell Sci , vol.126 , pp. 5553-5565
    • Colombo, M.1    Moita, C.2    van Niel, G.3
  • 28
    • 61349173156 scopus 로고    scopus 로고
    • Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes
    • COI: 1:CAS:528:DC%2BD1cXhtlGku7zP, PID: 19367702
    • Conde-Vancells J, Rodriguez-Suarez E, Embade N et al (2008) Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res 7:5157–5166. doi:10.1021/pr8004887
    • (2008) J Proteome Res , vol.7 , pp. 5157-5166
    • Conde-Vancells, J.1    Rodriguez-Suarez, E.2    Embade, N.3
  • 29
    • 84929156225 scopus 로고    scopus 로고
    • Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells
    • COI: 1:CAS:528:DC%2BC2cXhsFyltbbE, PID: 25242146
    • Cossetti C, Iraci N, Mercer TR et al (2014) Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells. Mol Cell 56:193–204. doi:10.1016/j.molcel.2014.08.020
    • (2014) Mol Cell , vol.56 , pp. 193-204
    • Cossetti, C.1    Iraci, N.2    Mercer, T.R.3
  • 30
    • 85026337731 scopus 로고    scopus 로고
    • Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes
    • Crescitelli R, Lässer C, Szabó TG et al (2013) Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes. J Extracell vesicles 2:1–10. doi:10.3402/jev.v2i0.20677
    • (2013) J Extracell vesicles , vol.2 , pp. 1-10
    • Crescitelli, R.1    Lässer, C.2    Szabó, T.G.3
  • 31
    • 85013156831 scopus 로고    scopus 로고
    • Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
    • de Jong OG, Verhaar MC, Chen Y, et al (2012) Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. J Extracell Vesicles
    • (2012) J Extracell Vesicles et al
    • de Jong, O.G.1    Verhaar, M.C.2    Chen, Y.3
  • 32
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
    • COI: 1:CAS:528:DC%2BD3cXnvF2gsb0%3D, PID: 10984428
    • Denzer K, Kleijmeer MJ, Heijnen HF et al (2000) Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 113(Pt 19):3365–3374
    • (2000) J Cell Sci , vol.113 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3
  • 33
    • 72049088519 scopus 로고    scopus 로고
    • TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways
    • COI: 1:CAS:528:DC%2BD1MXhsV2gsbzE, PID: 19781582
    • Fader CM, Sánchez DG, Mestre MB, Colombo MI (2009) TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta 1793:1901–1916. doi:10.1016/j.bbamcr.2009.09.011
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1901-1916
    • Fader, C.M.1    Sánchez, D.G.2    Mestre, M.B.3    Colombo, M.I.4
  • 34
    • 77953154769 scopus 로고    scopus 로고
    • Cellular internalization of exosomes occurs through phagocytosis
    • COI: 1:CAS:528:DC%2BC3cXlt1Kis7Y%3D, PID: 20136776
    • Feng D, Zhao WL, Ye YY et al (2010) Cellular internalization of exosomes occurs through phagocytosis. Traffic 11:675–687. doi:10.1111/j.1600-0854.2010.01041.x
    • (2010) Traffic , vol.11 , pp. 675-687
    • Feng, D.1    Zhao, W.L.2    Ye, Y.Y.3
  • 35
    • 0032944031 scopus 로고    scopus 로고
    • Multivesicular body morphogenesis requires phosphatidylinositol 3-kinase activity
    • COI: 1:CAS:528:DyaK1MXntV2lsw%3D%3D, PID: 9889123
    • Fernandez-Borja M, Wubbolts R, Calafat J et al (1999) Multivesicular body morphogenesis requires phosphatidylinositol 3-kinase activity. Curr Biol 9:55–58. doi:10.1016/S0960-9822(99)80048-7
    • (1999) Curr Biol , vol.9 , pp. 55-58
    • Fernandez-Borja, M.1    Wubbolts, R.2    Calafat, J.3
  • 36
    • 79551542416 scopus 로고    scopus 로고
    • Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
    • COI: 1:CAS:528:DC%2BC3MXisFyjsro%3D, PID: 21242314
    • Fitzner D, Schnaars M, van Rossum D et al (2011) Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis. J Cell Sci 124:447–458. doi:10.1242/jcs.074088
    • (2011) J Cell Sci , vol.124 , pp. 447-458
    • Fitzner, D.1    Schnaars, M.2    van Rossum, D.3
  • 37
    • 84866269937 scopus 로고    scopus 로고
    • Emerging roles of exosomes in neuron-glia communication
    • PID: 22557979
    • Frühbeis C, Fröhlich D, Krämer-Albers EM (2012) Emerging roles of exosomes in neuron-glia communication. Front Physiol. doi:10.3389/fphys.2012.00119
    • (2012) Front Physiol
    • Frühbeis, C.1    Fröhlich, D.2    Krämer-Albers, E.M.3
  • 38
    • 84880950361 scopus 로고    scopus 로고
    • Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication
    • PID: 23874151
    • Frühbeis C, Fröhlich D, Kuo WP et al (2013) Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. doi:10.1371/journal.pbio.1001604
    • (2013) PLoS Biol
    • Frühbeis, C.1    Fröhlich, D.2    Kuo, W.P.3
  • 39
    • 84897865127 scopus 로고    scopus 로고
    • Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2
    • PID: 24637612
    • Ghossoub R, Lembo F, Rubio A et al (2014) Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2. Nat Commun 5:3477. doi:10.1038/ncomms4477
    • (2014) Nat Commun , vol.5 , pp. 3477
    • Ghossoub, R.1    Lembo, F.2    Rubio, A.3
  • 40
    • 69949117622 scopus 로고    scopus 로고
    • Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
    • COI: 1:CAS:528:DC%2BD1MXhtVKrsbnJ, PID: 19684575
    • Gibbings DJ, Ciaudo C, Erhardt M, Voinnet O (2009) Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat Cell Biol 11:1143–1149
    • (2009) Nat Cell Biol , vol.11 , pp. 1143-1149
    • Gibbings, D.J.1    Ciaudo, C.2    Erhardt, M.3    Voinnet, O.4
  • 41
    • 65249120179 scopus 로고    scopus 로고
    • Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)
    • COI: 1:CAS:528:DC%2BD1MXpsl2gtw%3D%3D, PID: 19199708
    • Gonzalez-Begne M, Lu B, Han X et al (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res 8:1304–1314
    • (2009) J Proteome Res , vol.8 , pp. 1304-1314
    • Gonzalez-Begne, M.1    Lu, B.2    Han, X.3
  • 42
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles
    • Gould SJ, Raposo G (2013) As we wait: coping with an imperfect nomenclature for extracellular vesicles. J Extracell Vesicles 2:3–5. doi:10.3402/jev.v2i0.20389
    • (2013) J Extracell Vesicles , vol.2 , pp. 3-5
    • Gould, S.J.1    Raposo, G.2
  • 43
    • 0141856621 scopus 로고    scopus 로고
    • The Trojan exosome hypothesis
    • COI: 1:CAS:528:DC%2BD3sXnslyns7o%3D, PID: 12947040
    • Gould SJ, Booth AM, Hildreth JEK (2003) The Trojan exosome hypothesis. Proc Natl Acad Sci USA 100:10592–10597. doi:10.1073/pnas.1831413100
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10592-10597
    • Gould, S.J.1    Booth, A.M.2    Hildreth, J.E.K.3
  • 44
    • 70349316341 scopus 로고    scopus 로고
    • Proteomic and immunologic analyses of brain tumor exosomes
    • COI: 1:CAS:528:DC%2BD1MXlsFSms7c%3D, PID: 19109410
    • Graner MW, Alzate O, Dechkovskaia AM et al (2009) Proteomic and immunologic analyses of brain tumor exosomes. FASEB J 23:1541–1557. doi:10.1096/fj.08-122184
    • (2009) FASEB J , vol.23 , pp. 1541-1557
    • Graner, M.W.1    Alzate, O.2    Dechkovskaia, A.M.3
  • 45
    • 69249106881 scopus 로고    scopus 로고
    • Pathways and mechanisms of endocytic recycling
    • COI: 1:CAS:528:DC%2BD1MXhtVaksrjP, PID: 19696797
    • Grant BD, Donaldson JG (2009) Pathways and mechanisms of endocytic recycling. Nat Rev Mol Cell Biol 10:597–608. doi:10.1038/nrm2755
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 597-608
    • Grant, B.D.1    Donaldson, J.G.2
  • 46
    • 84864411871 scopus 로고    scopus 로고
    • Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types
    • COI: 1:CAS:528:DC%2BC3sXmtVeqt70%3D
    • Guduric-Fuchs J, O’Connor A, Camp B et al (2012) Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genom 13:357. doi:10.1186/1471-2164-13-357
    • (2012) BMC Genom , vol.13 , pp. 357
    • Guduric-Fuchs, J.1    O’Connor, A.2    Camp, B.3
  • 47
    • 76949101800 scopus 로고    scopus 로고
    • Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
    • COI: 1:CAS:528:DC%2BD1MXhsFWmurjF, PID: 19680595
    • Guescini M, Genedani S, Stocchi V, Agnati LF (2010) Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J Neural Transm 117:1–4. doi:10.1007/s00702-009-0288-8
    • (2010) J Neural Transm , vol.117 , pp. 1-4
    • Guescini, M.1    Genedani, S.2    Stocchi, V.3    Agnati, L.F.4
  • 48
    • 79960944057 scopus 로고    scopus 로고
    • Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles
    • PID: 21560073
    • György B, Szabó TG, Pásztói M et al (2011) Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci 68:2667–2688
    • (2011) Cell Mol Life Sci , vol.68 , pp. 2667-2688
    • György, B.1    Szabó, T.G.2    Pásztói, M.3
  • 49
    • 84870586668 scopus 로고    scopus 로고
    • The genomic and proteomic content of cancer cell-derived exosomes
    • Henderson MC, Azorsa DO (2012) The genomic and proteomic content of cancer cell-derived exosomes. Front Oncol 2:3389
    • (2012) Front Oncol , vol.2 , pp. 3389
    • Henderson, M.C.1    Azorsa, D.O.2
  • 50
    • 79960225411 scopus 로고    scopus 로고
    • The ESCRT pathway
    • COI: 1:CAS:528:DC%2BC3MXptVSqsr8%3D, PID: 21763610
    • Henne WM, Buchkovich NJ, Emr SD (2011) The ESCRT pathway. Dev Cell 21:77–91
    • (2011) Dev Cell , vol.21 , pp. 77-91
    • Henne, W.M.1    Buchkovich, N.J.2    Emr, S.D.3
  • 52
    • 77951183654 scopus 로고    scopus 로고
    • Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C
    • COI: 1:CAS:528:DC%2BC3cXlt1Kgsr4%3D, PID: 20404108
    • Hsu C, Morohashi Y, Yoshimura SI et al (2010) Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol 189:223–232. doi:10.1083/jcb.200911018
    • (2010) J Cell Biol , vol.189 , pp. 223-232
    • Hsu, C.1    Morohashi, Y.2    Yoshimura, S.I.3
  • 53
    • 84877298502 scopus 로고    scopus 로고
    • Characterization of human plasma-derived exosomal RNAs by deep sequencing
    • COI: 1:CAS:528:DC%2BC3sXptlyiu7o%3D
    • Huang X, Yuan T, Tschannen M et al (2013) Characterization of human plasma-derived exosomal RNAs by deep sequencing. BMC Genom 14:319. doi:10.1186/1471-2164-14-319
    • (2013) BMC Genom , vol.14 , pp. 319
    • Huang, X.1    Yuan, T.2    Tschannen, M.3
  • 54
    • 84888329506 scopus 로고    scopus 로고
    • Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing
    • PID: 24255815
    • Jenjaroenpun P, Kremenska Y, Nair VM et al (2013) Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing. PeerJ 1:e201. doi:10.7717/peerj.201
    • (2013) PeerJ , vol.1 , pp. e201
    • Jenjaroenpun, P.1    Kremenska, Y.2    Nair, V.M.3
  • 55
    • 84871702725 scopus 로고    scopus 로고
    • Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
    • PID: 23271954
    • Kalra H, Simpson RJ, Ji H et al (2012) Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. doi:10.1371/journal.pbio.1001450
    • (2012) PLoS Biol
    • Kalra, H.1    Simpson, R.J.2    Ji, H.3
  • 56
    • 0035958546 scopus 로고    scopus 로고
    • Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
    • COI: 1:CAS:528:DC%2BD3MXlvVClsL8%3D, PID: 11511343
    • Katzmann DJ, Babst M, Emr SD (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106:145–155. doi:10.1016/S0092-8674(01)00434-2
    • (2001) Cell , vol.106 , pp. 145-155
    • Katzmann, D.J.1    Babst, M.2    Emr, S.D.3
  • 57
    • 84884932216 scopus 로고    scopus 로고
    • EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles
    • COI: 1:CAS:528:DC%2BC3sXhvVWrsbvM
    • Kim D-K, Kang B, Kim OY et al (2013) EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles. J Extracell Vesicles 2:1–7. doi:10.3402/jev.v2i0.20384
    • (2013) J Extracell Vesicles , vol.2 , pp. 1-7
    • Kim, D.-K.1    Kang, B.2    Kim, O.Y.3
  • 58
    • 84907415649 scopus 로고    scopus 로고
    • Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes
    • COI: 1:CAS:528:DC%2BC2cXhsFyltbfN, PID: 25242326
    • Koppers-Lalic D, Hackenberg M, Bijnsdorp IV et al (2014) Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes. Cell Reports 8:1649–1658
    • (2014) Cell Reports , vol.8 , pp. 1649-1658
    • Koppers-Lalic, D.1    Hackenberg, M.2    Bijnsdorp, I.V.3
  • 59
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • COI: 1:CAS:528:DC%2BC3cXmslSnurY%3D, PID: 20353945
    • Kosaka N, Iguchi H, Yoshioka Y et al (2010) Secretory mechanisms and intercellular transfer of microRNAs in living cells. J Biol Chem 285:17442–17452. doi:10.1074/jbc.M110.107821
    • (2010) J Biol Chem , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3
  • 60
    • 84929353279 scopus 로고    scopus 로고
    • Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
    • COI: 1:CAS:528:DC%2BC2MXhtF2ksb3N, PID: 25967391
    • Lai CP, Kim EY, Badr CE et al (2015) Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun 6:7029. doi:10.1038/ncomms8029
    • (2015) Nat Commun , vol.6 , pp. 7029
    • Lai, C.P.1    Kim, E.Y.2    Badr, C.E.3
  • 61
    • 4143088359 scopus 로고    scopus 로고
    • PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes
    • COI: 1:CAS:528:DC%2BD2cXmsVGhs78%3D, PID: 15304316
    • Laulagnier K, Grand D, Dujardin A et al (2004) PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes. FEBS Lett 572:11–14. doi:10.1016/j.febslet.2004.06.082
    • (2004) FEBS Lett , vol.572 , pp. 11-14
    • Laulagnier, K.1    Grand, D.2    Dujardin, A.3
  • 62
    • 84867569522 scopus 로고    scopus 로고
    • Argonaute 2 complexes selectively protect the circulating micrornas in cell-secreted microvesicles
    • Li L, Zhu D, Huang L et al (2012) Argonaute 2 complexes selectively protect the circulating micrornas in cell-secreted microvesicles. PLoS One. doi:10.1371/journal.pone.0046957
    • (2012) PLoS One
    • Li, L.1    Zhu, D.2    Huang, L.3
  • 63
    • 84883111834 scopus 로고    scopus 로고
    • Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells
    • COI: 1:CAS:528:DC%2BC2cXpslGgsA%3D%3D, PID: 23807490
    • Li CCY, Eaton SA, Young PE et al (2013) Glioma microvesicles carry selectively packaged coding and noncoding RNAs which alter gene expression in recipient cells. RNA Biol 10:1333–1344. doi:10.4161/rna.25281
    • (2013) RNA Biol , vol.10 , pp. 1333-1344
    • Li, C.C.Y.1    Eaton, S.A.2    Young, P.E.3
  • 64
    • 84938747588 scopus 로고    scopus 로고
    • Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis
    • Li Y, Zheng Q, Bao C et al (2015) Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. doi:10.1038/cr.2015.82
    • (2015) Cell Res
    • Li, Y.1    Zheng, Q.2    Bao, C.3
  • 65
    • 84878125516 scopus 로고    scopus 로고
    • Molecular lipidomics of exosomes released by PC-3 prostate cancer cells
    • COI: 1:CAS:528:DC%2BC3sXosVGksrs%3D, PID: 24046871
    • Llorente A, Skotland T, Sylvänne T et al (2013) Molecular lipidomics of exosomes released by PC-3 prostate cancer cells. Biochim Biophys Acta 1831:1302–1309. doi:10.1016/j.bbalip.2013.04.011
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 1302-1309
    • Llorente, A.1    Skotland, T.2    Sylvänne, T.3
  • 66
    • 33744458462 scopus 로고    scopus 로고
    • A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils
    • COI: 1:CAS:528:DC%2BD28XmtlWltr4%3D
    • Logan MR, Lacy P, Odemuyiwa SO et al (2006) A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Allergy Eur J Allergy Clin Immunol 61:777–784. doi:10.1111/j.1398-9995.2006.01089.x
    • (2006) Allergy Eur J Allergy Clin Immunol , vol.61 , pp. 777-784
    • Logan, M.R.1    Lacy, P.2    Odemuyiwa, S.O.3
  • 67
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
    • PID: 25536934
    • Lötvall J, Hill AF, Hochberg F et al (2014) Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 3:26913. doi:10.3402/jev.v3.26913
    • (2014) J Extracell Vesicles , vol.3 , pp. 26913
    • Lötvall, J.1    Hill, A.F.2    Hochberg, F.3
  • 68
    • 84871563123 scopus 로고    scopus 로고
    • Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration
    • COI: 1:CAS:528:DC%2BC38XhvVymu7nP, PID: 23260141
    • Luga V, Zhang L, Viloria-Petit AM et al (2012) Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 151:1542–1556. doi:10.1016/j.cell.2012.11.024
    • (2012) Cell , vol.151 , pp. 1542-1556
    • Luga, V.1    Zhang, L.2    Viloria-Petit, A.M.3
  • 69
    • 84866685704 scopus 로고    scopus 로고
    • Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells
    • Marcilla A, Trelis M, Cortés A et al (2012) Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells. PLoS One. doi:10.1371/journal.pone.0045974
    • (2012) PLoS One
    • Marcilla, A.1    Trelis, M.2    Cortés, A.3
  • 70
    • 70350449455 scopus 로고    scopus 로고
    • ExoCarta: a compendium of exosomal proteins and RNA
    • COI: 1:CAS:528:DC%2BD1MXhtleqtbbE, PID: 19810033
    • Mathivanan S, Simpson RJ (2009) ExoCarta: a compendium of exosomal proteins and RNA. Proteomics 9:4997–5000. doi:10.1002/pmic.200900351
    • (2009) Proteomics , vol.9 , pp. 4997-5000
    • Mathivanan, S.1    Simpson, R.J.2
  • 72
    • 9144273746 scopus 로고    scopus 로고
    • Role of LBPA and Alix in multivesicular liposome formation and endosome organization
    • COI: 1:CAS:528:DC%2BD2cXlt1emsQ%3D%3D, PID: 14739459
    • Matsuo H, Chevallier J, Mayran N et al (2004) Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303:531–534. doi:10.1126/science.1092425
    • (2004) Science , vol.303 , pp. 531-534
    • Matsuo, H.1    Chevallier, J.2    Mayran, N.3
  • 73
    • 45549101132 scopus 로고    scopus 로고
    • ALIX-CHMP4 interactions in the human ESCRT pathway
    • COI: 1:CAS:528:DC%2BD1cXnt1Srs7c%3D, PID: 18511562
    • McCullough J, Fisher RD, Whitby FG et al (2008) ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci USA 105:7687–7691. doi:10.1073/pnas.0801567105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7687-7691
    • McCullough, J.1    Fisher, R.D.2    Whitby, F.G.3
  • 74
    • 84929292388 scopus 로고    scopus 로고
    • Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes
    • COI: 1:CAS:528:DC%2BC2MXjs1Oltrk%3D, PID: 25721812
    • Minciacchi VR, Freeman MR, Di Vizio D (2015) Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. Semin Cell Dev Biol 40:41–51
    • (2015) Semin Cell Dev Biol , vol.40 , pp. 41-51
    • Minciacchi, V.R.1    Freeman, M.R.2    Di Vizio, D.3
  • 75
    • 84867126923 scopus 로고    scopus 로고
    • Alternative methods for characterization of extracellular vesicles
    • Momen-Heravi F, Balaj L, Alian S et al (2012) Alternative methods for characterization of extracellular vesicles. Front Physiol 3:3389
    • (2012) Front Physiol , vol.3 , pp. 3389
    • Momen-Heravi, F.1    Balaj, L.2    Alian, S.3
  • 76
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • COI: 1:CAS:528:DC%2BC38Xhs1Kjtb0%3D, PID: 22031862
    • Montecalvo A, Larregina AT, Shufesky WJ et al (2012) Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119:756–766. doi:10.1182/blood-2011-02-338004
    • (2012) Blood , vol.119 , pp. 756-766
    • Montecalvo, A.1    Larregina, A.T.2    Shufesky, W.J.3
  • 77
    • 8644286802 scopus 로고    scopus 로고
    • Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
    • COI: 1:CAS:528:DC%2BD2cXhtVWhurrI, PID: 15284116
    • Morelli AE, Larregina AT, Shufesky WJ et al (2004) Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 104:3257–3266. doi:10.1182/blood-2004-03-0824
    • (2004) Blood , vol.104 , pp. 3257-3266
    • Morelli, A.E.1    Larregina, A.T.2    Shufesky, W.J.3
  • 78
    • 85013654823 scopus 로고    scopus 로고
    • Routes and mechanisms of extracellular vesicle uptake
    • Mulcahy LA, Pink RC, Carter DRF (2014) Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles 3:1–14. doi:10.3402/jev.v3.24641
    • (2014) J Extracell Vesicles , vol.3 , pp. 1-14
    • Mulcahy, L.A.1    Pink, R.C.2    Carter, D.R.F.3
  • 79
    • 0033607521 scopus 로고    scopus 로고
    • Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking
    • COI: 1:CAS:528:DyaK1MXnslOktLs%3D, PID: 10567417
    • Munro TP, Magee RJ, Kidd GJ et al (1999) Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking. J Biol Chem 274:34389–34395. doi:10.1074/jbc.274.48.34389
    • (1999) J Biol Chem , vol.274 , pp. 34389-34395
    • Munro, T.P.1    Magee, R.J.2    Kidd, G.J.3
  • 80
    • 70450170492 scopus 로고    scopus 로고
    • ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles
    • COI: 1:CAS:528:DC%2BD1MXhsV2hu7vI, PID: 19896381
    • Muralidharan-Chari V, Clancy J, Plou C et al (2009) ARF6-regulated shedding of tumor cell-derived plasma membrane microvesicles. Curr Biol 19:1875–1885. doi:10.1016/j.cub.2009.09.059
    • (2009) Curr Biol , vol.19 , pp. 1875-1885
    • Muralidharan-Chari, V.1    Clancy, J.2    Plou, C.3
  • 82
    • 84930225125 scopus 로고    scopus 로고
    • Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes
    • PID: 26011176
    • Nakase I, Futaki S (2015) Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes. Sci Rep 5:10112. doi:10.1038/srep10112
    • (2015) Sci Rep , vol.5 , pp. 10112
    • Nakase, I.1    Futaki, S.2
  • 83
    • 84883301160 scopus 로고    scopus 로고
    • Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells
    • COI: 1:CAS:528:DC%2BC3sXhsVSgt77M, PID: 23864627
    • Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H (2013) Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells. J Virol 87:10334–10347. doi:10.1128/JVI.01310-13
    • (2013) J Virol , vol.87 , pp. 10334-10347
    • Nanbo, A.1    Kawanishi, E.2    Yoshida, R.3    Yoshiyama, H.4
  • 84
    • 84867546396 scopus 로고    scopus 로고
    • Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions
    • PID: 22821563
    • Nolte’T Hoen ENM, Buermans HPJ, Waasdorp M et al (2012) Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions. Nucleic Acids Res 40:9272–9285. doi:10.1093/nar/gks658
    • (2012) Nucleic Acids Res , vol.40 , pp. 9272-9285
    • Nolte’T Hoen, E.N.M.1    Buermans, H.P.J.2    Waasdorp, M.3
  • 85
    • 84872712527 scopus 로고    scopus 로고
    • Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing
    • COI: 1:CAS:528:DC%2BC3sXkvVOgsb4%3D, PID: 23302638
    • Ogawa Y, Taketomi Y, Murakami M et al (2013) Small RNA transcriptomes of two types of exosomes in human whole saliva determined by next generation sequencing. Biol Pharm Bull 36:66–75. doi:10.1248/bpb.b12-00607
    • (2013) Biol Pharm Bull , vol.36 , pp. 66-75
    • Ogawa, Y.1    Taketomi, Y.2    Murakami, M.3
  • 86
    • 79953136097 scopus 로고    scopus 로고
    • Rab27a and Rab27b control different steps of the exosome secretion pathway
    • COI: 1:CAS:528:DC%2BD1MXhsFynurrK, PID: 19966785
    • Ostrowski M, Carmo NB, Krumeich S et al (2010) Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 12:19–30. doi:10.1038/ncb2000
    • (2010) Nat Cell Biol , vol.12 , pp. 19-30
    • Ostrowski, M.1    Carmo, N.B.2    Krumeich, S.3
  • 87
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • COI: 1:CAS:528:DyaL3sXltF2rurk%3D, PID: 6307529
    • Pan BT, Johnstone RM (1983) Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33(3):967–978
    • (1983) Cell , vol.33 , Issue.3 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 88
    • 71749102668 scopus 로고    scopus 로고
    • Microenvironmental pH is a key factor for exosome traffic in tumor cells
    • COI: 1:CAS:528:DC%2BD1MXhsVymu7fN, PID: 19801663
    • Parolini I, Federici C, Raggi C et al (2009) Microenvironmental pH is a key factor for exosome traffic in tumor cells. J Biol Chem 284:34211–34222. doi:10.1074/jbc.M109.041152
    • (2009) J Biol Chem , vol.284 , pp. 34211-34222
    • Parolini, I.1    Federici, C.2    Raggi, C.3
  • 89
    • 0029947673 scopus 로고    scopus 로고
    • Calcium influx is a determining factor of calpain activation and microparticle formation in platelets
    • COI: 1:CAS:528:DyaK28XltFart7o%3D, PID: 8774708
    • Pasquet JM, Dachary-Prigent J, Nurden AT (1996) Calcium influx is a determining factor of calpain activation and microparticle formation in platelets. Eur J Biochem 239:647–654
    • (1996) Eur J Biochem , vol.239 , pp. 647-654
    • Pasquet, J.M.1    Dachary-Prigent, J.2    Nurden, A.T.3
  • 90
    • 84973922940 scopus 로고    scopus 로고
    • Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex
    • Patel B, Patel J, Cho J-H et al (2015) Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex. Oncogene. doi:10.1038/onc.2015.358
    • (2015) Oncogene
    • Patel, B.1    Patel, J.2    Cho, J.-H.3
  • 91
    • 77950889558 scopus 로고    scopus 로고
    • Functional delivery of viral miRNAs via exosomes
    • COI: 1:CAS:528:DC%2BC3cXkslehsLo%3D, PID: 20304794
    • Pegtel DM, Cosmopoulos K, Thorley-Lawson DA et al (2010) Functional delivery of viral miRNAs via exosomes. Proc Natl Acad Sci USA 107:6328–6333. doi:10.1073/pnas.0914843107
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6328-6333
    • Pegtel, D.M.1    Cosmopoulos, K.2    Thorley-Lawson, D.A.3
  • 92
    • 78149419143 scopus 로고    scopus 로고
    • Selective release of MicroRNA species from normal and malignant mammary epithelial cells
    • PID: 20976003
    • Pigati L, Yaddanapudi SCS, Iyengar R et al (2010) Selective release of MicroRNA species from normal and malignant mammary epithelial cells. PLoS One 5:e13515
    • (2010) PLoS One , vol.5 , pp. e13515
    • Pigati, L.1    Yaddanapudi, S.C.S.2    Iyengar, R.3
  • 93
    • 84946113945 scopus 로고    scopus 로고
    • Nanoparticle targeting and cholesterol flux through scavenger receptor type B-1 inhibits cellular exosome uptake
    • COI: 1:CAS:528:DC%2BC2MXhslCnu7fJ, PID: 26511855
    • Plebanek MP, Mutharasan RK, Volpert O et al (2015) Nanoparticle targeting and cholesterol flux through scavenger receptor type B-1 inhibits cellular exosome uptake. Sci Rep 5:15724. doi:10.1038/srep15724
    • (2015) Sci Rep , vol.5 , pp. 15724
    • Plebanek, M.P.1    Mutharasan, R.K.2    Volpert, O.3
  • 94
    • 67349263394 scopus 로고    scopus 로고
    • Trafficking and function of the tetraspanin CD63
    • COI: 1:CAS:528:DC%2BD1MXltVyquro%3D, PID: 18930046
    • Pols MS, Klumperman J (2009) Trafficking and function of the tetraspanin CD63. Exp Cell Res 315:1584–1592
    • (2009) Exp Cell Res , vol.315 , pp. 1584-1592
    • Pols, M.S.1    Klumperman, J.2
  • 95
    • 40649110538 scopus 로고    scopus 로고
    • Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms
    • COI: 1:CAS:528:DC%2BD1cXis1Kqt70%3D, PID: 18250339
    • Puri N, Roche PA (2008) Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. Proc Natl Acad Sci USA 105:2580–2585. doi:10.1073/pnas.0707854105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2580-2585
    • Puri, N.1    Roche, P.A.2
  • 96
    • 63649086486 scopus 로고    scopus 로고
    • The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    • COI: 1:CAS:528:DC%2BD1MXjs1Klurs%3D, PID: 19325624
    • Raiborg C, Stenmark H (2009) The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 458:445–452. doi:10.1038/nature07961
    • (2009) Nature , vol.458 , pp. 445-452
    • Raiborg, C.1    Stenmark, H.2
  • 97
    • 2442584514 scopus 로고    scopus 로고
    • Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis
    • COI: 1:CAS:528:DC%2BD2cXjs1Wgsbc%3D, PID: 14993220
    • Rao SK, Huynh C, Proux-Gillardeaux V et al (2004) Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis. J Biol Chem 279:20471–20479. doi:10.1074/jbc.M400798200
    • (2004) J Biol Chem , vol.279 , pp. 20471-20479
    • Rao, S.K.1    Huynh, C.2    Proux-Gillardeaux, V.3
  • 98
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • COI: 1:CAS:528:DC%2BC3sXjtFCnsbk%3D, PID: 23420871
    • Raposo G, Stoorvogel W (2013) Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol 200:373–383
    • (2013) J Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 99
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    • COI: 1:CAS:528:DC%2BD28XjslOhsbs%3D, PID: 16453000
    • Ratajczak J, Miekus K, Kucia M et al (2006) Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20:847–856. doi:10.1038/sj.leu.2404132
    • (2006) Leukemia , vol.20 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3
  • 100
    • 33745929286 scopus 로고    scopus 로고
    • Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation
    • COI: 1:CAS:528:DC%2BD28Xot1ynt7g%3D, PID: 16707569
    • Razi M, Futter CE (2006) Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation. Mol Biol Cell 17:3469–3483. doi:10.1091/mbc.E05-11-1054
    • (2006) Mol Biol Cell , vol.17 , pp. 3469-3483
    • Razi, M.1    Futter, C.E.2
  • 101
    • 84878291129 scopus 로고    scopus 로고
    • Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
    • COI: 1:CAS:528:DC%2BC3sXnslChsbw%3D, PID: 23683579
    • Regev-Rudzki N, Wilson DW, Carvalho TG et al (2013) Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell 153:1120–1133. doi:10.1016/j.cell.2013.04.029
    • (2013) Cell , vol.153 , pp. 1120-1133
    • Regev-Rudzki, N.1    Wilson, D.W.2    Carvalho, T.G.3
  • 102
    • 84903289462 scopus 로고    scopus 로고
    • Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation
    • PID: 24893313
    • Ridder K, Keller S, Dams M et al (2014) Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol 12:e1001874
    • (2014) PLoS Biol , vol.12 , pp. e1001874
    • Ridder, K.1    Keller, S.2    Dams, M.3
  • 103
    • 84879885842 scopus 로고    scopus 로고
    • Hyaluronan production enhances shedding of plasma membrane-derived microvesicles
    • COI: 1:CAS:528:DC%2BC3sXpslKlt7k%3D, PID: 23732660
    • Rilla K, Pasonen-Seppänen S, Deen AJ et al (2013) Hyaluronan production enhances shedding of plasma membrane-derived microvesicles. Exp Cell Res 319:2006–2018. doi:10.1016/j.yexcr.2013.05.021
    • (2013) Exp Cell Res , vol.319 , pp. 2006-2018
    • Rilla, K.1    Pasonen-Seppänen, S.2    Deen, A.J.3
  • 104
    • 84904916177 scopus 로고    scopus 로고
    • Hyaluronan-coated extracellular vesicles- A novel link between hyaluronan and cancer
    • PID: 25081528
    • Rilla K, Siiskonen H, Tammi M, Tammi R (2014) Hyaluronan-coated extracellular vesicles- A novel link between hyaluronan and cancer. Adv Cancer Res 123:121–148. doi:10.1016/B978-0-12-800092-2.00005-8
    • (2014) Adv Cancer Res , vol.123 , pp. 121-148
    • Rilla, K.1    Siiskonen, H.2    Tammi, M.3    Tammi, R.4
  • 105
    • 84926524813 scopus 로고    scopus 로고
    • Heparanase activates the syndecan-syntenin-ALIX exosome pathway
    • COI: 1:CAS:528:DC%2BC2MXjvFWks7w%3D, PID: 25732677
    • Roucourt B, Meeussen S, Bao J et al (2015) Heparanase activates the syndecan-syntenin-ALIX exosome pathway. Cell Res 25:412–428. doi:10.1038/cr.2015.29
    • (2015) Cell Res , vol.25 , pp. 412-428
    • Roucourt, B.1    Meeussen, S.2    Bao, J.3
  • 106
    • 0037490207 scopus 로고    scopus 로고
    • Exosome release is regulated by a calcium-dependent mechanism in K562 cells
    • COI: 1:CAS:528:DC%2BD3sXktVaqurk%3D, PID: 12639953
    • Savina A, Furlán M, Vidal M, Colombo MI (2003) Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J Biol Chem 278:20083–20090. doi:10.1074/jbc.M301642200
    • (2003) J Biol Chem , vol.278 , pp. 20083-20090
    • Savina, A.1    Furlán, M.2    Vidal, M.3    Colombo, M.I.4
  • 107
    • 84966505028 scopus 로고    scopus 로고
    • Servier LL (2016)
    • Servier LL (2016). http://www.servier.com/Powerpoint-image-bank
  • 108
    • 65349101661 scopus 로고    scopus 로고
    • ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting
    • COI: 1:CAS:528:DC%2BD1MXlt1yjt7s%3D, PID: 19380877
    • Shields SB, Oestreich AJ, Winistorfer S et al (2009) ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting. J Cell Biol 185:213–224. doi:10.1083/jcb.200811130
    • (2009) J Cell Biol , vol.185 , pp. 213-224
    • Shields, S.B.1    Oestreich, A.J.2    Winistorfer, S.3
  • 110
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • COI: 1:CAS:528:DC%2BD1cXhsVentbfI, PID: 19011622
    • Skog J, Würdinger T, van Rijn S et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470–1476. doi:10.1038/ncb1800
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Würdinger, T.2    van Rijn, S.3
  • 111
    • 84922527336 scopus 로고    scopus 로고
    • Endogenous RNAs modulate MicroRNA sorting to exosomes and transfer to acceptor cells
    • COI: 1:CAS:528:DC%2BC2cXhsVarsb7L, PID: 25159140
    • Squadrito ML, Baer C, Burdet F et al (2014) Endogenous RNAs modulate MicroRNA sorting to exosomes and transfer to acceptor cells. Cell Reports 8:1432–1446
    • (2014) Cell Reports , vol.8 , pp. 1432-1446
    • Squadrito, M.L.1    Baer, C.2    Burdet, F.3
  • 112
    • 68049105101 scopus 로고    scopus 로고
    • Rab GTPases as coordinators of vesicle traffic
    • COI: 1:CAS:528:DC%2BD1MXosFWhsrs%3D, PID: 19603039
    • Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10:513–525. doi:10.1038/nrm2728
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 513-525
    • Stenmark, H.1
  • 113
    • 0025755923 scopus 로고
    • Late endosomes derive from early endosomes by maturation
    • COI: 1:CAS:528:DyaK3MXktVGlsLg%3D, PID: 1850321
    • Stoorvogel W, Strous GJ, Geuze HJ et al (1991) Late endosomes derive from early endosomes by maturation. Cell 65:417–427. doi:10.1016/0092-8674(91)90459-C
    • (1991) Cell , vol.65 , pp. 417-427
    • Stoorvogel, W.1    Strous, G.J.2    Geuze, H.J.3
  • 114
    • 67249110996 scopus 로고    scopus 로고
    • Multivesicular endosome biogenesis in the absence of ESCRTs
    • COI: 1:CAS:528:DC%2BD1MXotFGrsbo%3D, PID: 19490536
    • Stuffers S, Sem Wegner C, Stenmark H, Brech A (2009) Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 10:925–937. doi:10.1111/j.1600-0854.2009.00920.x
    • (2009) Traffic , vol.10 , pp. 925-937
    • Stuffers, S.1    Sem Wegner, C.2    Stenmark, H.3    Brech, A.4
  • 115
    • 33846502114 scopus 로고    scopus 로고
    • Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies
    • COI: 1:CAS:528:DC%2BD2sXhtlaqs7g%3D, PID: 17157973
    • Subra C, Laulagnier K, Perret B, Record M (2007) Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies. Biochimie 89:205–212
    • (2007) Biochimie , vol.89 , pp. 205-212
    • Subra, C.1    Laulagnier, K.2    Perret, B.3    Record, M.4
  • 116
    • 84879046970 scopus 로고    scopus 로고
    • Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1
    • COI: 1:CAS:528:DC%2BC3sXpsFagtro%3D, PID: 23653359
    • Svensson KJ, Christianson HC, Wittrup A et al (2013) Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem 288:17713–17724. doi:10.1074/jbc.M112.445403
    • (2013) J Biol Chem , vol.288 , pp. 17713-17724
    • Svensson, K.J.1    Christianson, H.C.2    Wittrup, A.3
  • 117
    • 77956171863 scopus 로고    scopus 로고
    • Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein
    • COI: 1:CAS:528:DC%2BC3cXhtV2gur3K, PID: 20673754
    • Tamai K, Tanaka N, Nakano T et al (2010) Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein. Biochem Biophys Res Commun 399:384–390. doi:10.1016/j.bbrc.2010.07.083
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 384-390
    • Tamai, K.1    Tanaka, N.2    Nakano, T.3
  • 118
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • COI: 1:CAS:528:DC%2BC38XjtVWgtLo%3D, PID: 22285593
    • Tauro BJ, Greening DW, Mathias RA et al (2012) Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods 56:293–304. doi:10.1016/j.ymeth.2012.01.002
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3
  • 119
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles
    • PID: 11390481
    • Théry C, Boussac M, Véron P et al (2001) Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 166:7309–7318. doi:10.4049/jimmunol.166.12.7309
    • (2001) J Immunol , vol.166 , pp. 7309-7318
    • Théry, C.1    Boussac, M.2    Véron, P.3
  • 120
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: composition, biogenesis and function
    • PID: 12154376
    • Théry C, Zitvogel L, Amigorena S (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2:569–579. doi:10.1038/nri855
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Théry, C.1    Zitvogel, L.2    Amigorena, S.3
  • 121
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • PID: 19498381
    • Théry C, Ostrowski M, Segura E (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9:581–593. doi:10.1038/nri2567
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 122
    • 43549084201 scopus 로고    scopus 로고
    • VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways
    • COI: 1:CAS:528:DC%2BD1cXktlWmsbY%3D, PID: 18203950
    • Tiwari N, Wang CC, Brochetta C et al (2008) VAMP-8 segregates mast cell-preformed mediator exocytosis from cytokine trafficking pathways. Blood 111:3665–3674. doi:10.1182/blood-2007-07-103309
    • (2008) Blood , vol.111 , pp. 3665-3674
    • Tiwari, N.1    Wang, C.C.2    Brochetta, C.3
  • 123
    • 80052035289 scopus 로고    scopus 로고
    • Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice
    • PID: 21635979
    • Turiák L, Misják P, Szabó TG et al (2011) Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice. J Proteomics 74:2025–2033. doi:10.1016/j.jprot.2011.05.023
    • (2011) J Proteomics , vol.74 , pp. 2025-2033
    • Turiák, L.1    Misják, P.2    Szabó, T.G.3
  • 124
    • 0019904731 scopus 로고
    • Comparative lipid analysis of purified plasma membranes and shed extracellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells
    • PID: 7104337
    • Van Blitterswijk WJ, De Veer G, Krol JH, Emmelot P (1982) Comparative lipid analysis of purified plasma membranes and shed extracellular membrane vesicles from normal murine thymocytes and leukemic GRSL cells. Biochim Biophys Acta 688:495–504. doi:10.1016/0005-2736(82)90361-3
    • (1982) Biochim Biophys Acta , vol.688 , pp. 495-504
    • Van Blitterswijk, W.J.1    De Veer, G.2    Krol, J.H.3    Emmelot, P.4
  • 125
    • 84858783222 scopus 로고    scopus 로고
    • Lipid-based carriers of microRNAs and intercellular communication
    • COI: 1:CAS:528:DC%2BC38XjslamsrY%3D, PID: 22418571
    • Vickers KC, Remaley AT (2012) Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol 23:91–97
    • (2012) Curr Opin Lipidol , vol.23 , pp. 91-97
    • Vickers, K.C.1    Remaley, A.T.2
  • 126
    • 79953301730 scopus 로고    scopus 로고
    • MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
    • COI: 1:CAS:528:DC%2BC3MXktFWjsb4%3D, PID: 21423178
    • Vickers KC, Palmisano BT, Shoucri BM et al (2011) MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol 13:423–433. doi:10.1038/ncb2210
    • (2011) Nat Cell Biol , vol.13 , pp. 423-433
    • Vickers, K.C.1    Palmisano, B.T.2    Shoucri, B.M.3
  • 127
    • 84890907806 scopus 로고    scopus 로고
    • Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs
    • PID: 24356509
    • Villarroya-Beltri C, Gutiérrez-Vázquez C, Sánchez-Cabo F et al (2013) Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun 4:2980. doi:10.1038/ncomms3980
    • (2013) Nat Commun , vol.4 , pp. 2980
    • Villarroya-Beltri, C.1    Gutiérrez-Vázquez, C.2    Sánchez-Cabo, F.3
  • 128
    • 84859608013 scopus 로고    scopus 로고
    • Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells
    • Waldenström A, Gennebäck N, Hellman U, Ronquist G (2012) Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS One. doi:10.1371/journal.pone.0034653
    • (2012) PLoS One
    • Waldenström, A.1    Gennebäck, N.2    Hellman, U.3    Ronquist, G.4
  • 129
    • 84905643012 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
    • COI: 1:CAS:528:DC%2BC2cXpvVSlsLo%3D, PID: 24938788
    • Wang T, Gilkes DM, Takano N et al (2014) Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci USA 111:E3234–E3242. doi:10.1073/pnas.1410041111
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. E3234-E3242
    • Wang, T.1    Gilkes, D.M.2    Takano, N.3
  • 130
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • Witwer KW, Buzás EI, Bemis LT et al (2013) Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles 2:1–25. doi:10.3402/jev.v2i0.20360
    • (2013) J Extracell Vesicles , vol.2 , pp. 1-25
    • Witwer, K.W.1    Buzás, E.I.2    Bemis, L.T.3
  • 131
    • 77950863406 scopus 로고    scopus 로고
    • Molecular mechanism of multivesicular body biogenesis by ESCRT complexes
    • COI: 1:CAS:528:DC%2BC3cXjs1ehtbc%3D, PID: 20305637
    • Wollert T, Hurley JH (2010) Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature 464:864–869. doi:10.1038/nature08849
    • (2010) Nature , vol.464 , pp. 864-869
    • Wollert, T.1    Hurley, J.H.2
  • 132
    • 0013495952 scopus 로고    scopus 로고
    • Proteomic and biochemical analyses of human B cell-derived exosomes: potential implications for their function and multivesicular body formation
    • COI: 1:CAS:528:DC%2BD3sXit1Khu7s%3D, PID: 12519789
    • Wubbolts R, Leckie RS, Veenhuizen PTM et al (2003) Proteomic and biochemical analyses of human B cell-derived exosomes: potential implications for their function and multivesicular body formation. J Biol Chem 278:10963–10972. doi:10.1074/jbc.M207550200
    • (2003) J Biol Chem , vol.278 , pp. 10963-10972
    • Wubbolts, R.1    Leckie, R.S.2    Veenhuizen, P.T.M.3
  • 133
    • 84867327663 scopus 로고    scopus 로고
    • Identifying mRNA, microrna and protein profiles of melanoma exosomes
    • Xiao D, Ohlendorf J, Chen Y et al (2012) Identifying mRNA, microrna and protein profiles of melanoma exosomes. PLoS One. doi:10.1371/journal.pone.0046874
    • (2012) PLoS One
    • Xiao, D.1    Ohlendorf, J.2    Chen, Y.3
  • 134
    • 84873119802 scopus 로고    scopus 로고
    • The cis-acting signals that target proteins to exosomes and microvesicles
    • COI: 1:CAS:528:DC%2BC3sXhs1eiu70%3D, PID: 23356297
    • Yang J-M, Gould SJ (2013) The cis-acting signals that target proteins to exosomes and microvesicles. Biochem Soc Trans 41:277–282. doi:10.1042/BST20120275
    • (2013) Biochem Soc Trans , vol.41 , pp. 277-282
    • Yang, J.-M.1    Gould, S.J.2
  • 135
    • 84938826085 scopus 로고    scopus 로고
    • Extracellular vesicles: composition, biological relevance, and methods of study
    • PID: 26955082
    • Zaborowski MP, Balaj L, Breakefield XO, Lai CP (2015) Extracellular vesicles: composition, biological relevance, and methods of study. Bioscience 65:783–797. doi:10.1093/biosci/biv084
    • (2015) Bioscience , vol.65 , pp. 783-797
    • Zaborowski, M.P.1    Balaj, L.2    Breakefield, X.O.3    Lai, C.P.4


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