Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 22, 2018, Pages E5106-E5114

  Sun, Kun ^a,b   Jiang, Peiyong ^a,b   Wong, Ada I C ^a,b   Cheng, Yvonne K Y ^b   Cheng, Suk Hang ^a,b   Zhang, Haiqiang ^a,b   Allen Chan, K C ^a,b   Leung, Tak Y ^b   Chiu, Rossa W K ^a,b   Dennis Lo, Y M ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Circulating cell free DNA; Liquid biopsy; Nucleosome structure; Renatal dia nosis; Size based molecular diagnostics

Indexed keywords

DNA; PLASMA DNA; UNCLASSIFIED DRUG; CELL FREE NUCLEIC ACID;

ACCURACY; ARTICLE; CELL STRUCTURE; CHROMATIN; DNA DETERMINATION; FRACTIONATION; HUMAN; LEUKOCYTE; MATERNAL PLASMA; NON INVASIVE PROCEDURE; NUCLEOSOME; PLACENTA; PREGNANCY; PRENATAL SCREENING; PRIORITY JOURNAL; TRISOMY 21; BLOOD; CASE CONTROL STUDY; CHEMISTRY; CLASSIFICATION; FEMALE; FETUS; LIQUID BIOPSY; MOLECULAR DIAGNOSIS; PHYSIOLOGY; PRENATAL DIAGNOSIS; PROCEDURES;

CASE-CONTROL STUDIES; CELL-FREE NUCLEIC ACIDS; FEMALE; FETUS; HUMANS; LIQUID BIOPSY; MOLECULAR DIAGNOSTIC TECHNIQUES; NUCLEOSOMES; PREGNANCY; PRENATAL DIAGNOSIS;

EID: 85047929804     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1804134115     Document Type: Article

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