Type I IFNs drive hematopoietic stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like ehrlichial infection

PLoS Pathogens

Volumn 14, Issue 8, 2018, Pages

  Smith, Julianne N P ^a,b   Zhang, Yubin ^a,c   Li, Jing Jing ^a   McCabe, Amanda ^a,d   Jo, Hui Jin ^a   Maloney, Jackson ^a   MacNamara, Katherine C ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c FUDAN UNIVERSITY   (China)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON RECEPTOR; ANTIBIOTIC AGENT; BETA ACTIN; BETA INTERFERON; CASPASE 3; CASPASE 7; CASPASE 8; CD11B ANTIGEN; CD135 ANTIGEN; CD150 ANTIGEN; CD16 ANTIGEN; CD32 ANTIGEN; CD34 ANTIGEN; CD48 ANTIGEN; DOXYCYCLINE; IFNAR1 PROTEIN; INTERLEUKIN 7 RECEPTOR; LY6C PROTEIN; NECROSTATIN 1; PEPTIDES AND PROTEINS; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RECEPTOR INTERACTING SERINE THREONINE PROTEIN KINASE 1; RECEPTOR INTERACTING SERINE THREONINE PROTEIN KINASE 3; STEM CELL FACTOR; UNCLASSIFIED DRUG; INTERFERON; RIPK1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; APOPTOSIS; ARTICLE; BACTERIAL LOAD; BACTERIAL VIRULENCE; BLOOD CELL COUNT; BONE MARROW; BONE MARROW DEPRESSION; BONE MARROW TRANSPLANTATION; CELL AGING, CELL DEGENERATION AND CELL SURVIVAL; CELL LOSS; CELL PROLIFERATION; CELL QUIESCENCE; COLONY FORMING UNIT GM; COMBINATION DRUG THERAPY; CONTROLLED STUDY; CONVALESCENCE; CYTOKINE PRODUCTION; EHRLICHIOSIS; ENZYME ACTIVITY; EXTRAMEDULLARY HEMATOPOIESIS; FEMALE; HEMATOPOIETIC STEM CELL; INFLAMMATION; MALE; MONOCYTE; MOUSE; MYELOID PROGENITOR CELL; MYELOPOIESIS; NONHUMAN; OP9 CELL LINE; PHENOTYPE; PROTEIN CLEAVAGE; PROTEIN EXPRESSION LEVEL; SHOCK; SIGNAL TRANSDUCTION; SPLEEN; SURVIVOR; TICK BORNE DISEASE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL DEATH; CELL DIFFERENTIATION; DOWN REGULATION; DRUG EFFECT; EHRLICHIA; GENETICS; HEMATOPOIESIS; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; EHRLICHIA; EHRLICHIOSIS; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INTERFERON TYPE I; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SHOCK;

EID: 85053085751     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1007234     Document Type: Article

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