Type I interferon contributes to noncanonical inflammasome activation, mediates immunopathology, and impairs protective immunity during fatal infection with lipopolysaccharide-negative ehrlichiae

American Journal of Pathology

Volumn 185, Issue 2, 2015, Pages 446-461

  Yang, Qin ^a   Stevenson, Heather L ^a   Scott, Melanie J ^a   Ismail, Nahed ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; INFLAMMASOME; INTERFERON; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; ALPHA BETA INTERFERON RECEPTOR; CASP11 PROTEIN, MOUSE; CASPASE; GAMMA INTERFERON; IFNAR1 PROTEIN, MOUSE; IL10 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; INTERLEUKIN 10;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; BACTERIAL LOAD; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EHRLICHIA; EHRLICHIA CHAFFEENSIS; EHRLICHIOSIS; FATALITY; HOST SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNITY; IMMUNOPATHOLOGY; LIVER INJURY; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELLULAR IMMUNITY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TH1 CELL;

ANIMALS; CASPASES; EHRLICHIA; EHRLICHIOSIS; IMMUNITY, CELLULAR; INFLAMMASOMES; INTERFERON TYPE I; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; TH1 CELLS;

EID: 84922333666     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.10.005     Document Type: Article

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