Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 26, 2018, Pages E5944-E5953

  Amin, Palak ^a   Florez, Marcus ^a   Najafov, Ayaz ^a   Pan, Heling ^b   Geng, Jiefei ^a   Ofengeim, Dimitry ^a   Dziedzic, Slawomir A ^a   Wang, Huibing ^a   Barrett, Vica Jean ^a   Ito, Yasushi ^a   LaVoie, Matthew J ^c   Yuan, Junying ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Apoptosis; Necroptosis; RIPK1; TNF; Ubiquitination

Indexed keywords

ANAPHASE PROMOTING COMPLEX SUBUNIT 11; CASPASE 8; CBL PROTEIN; CELL PROTEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; LEUCINE RICH REPEAT KINASE 2; NIMA RELATED KINASE 1; RIPK1 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CBL PROTEIN, MOUSE; LRRK2 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, MOUSE;

ANIMAL CELL; APC11 GENE; APOPTOSIS; ARTICLE; C CBL GENE; CELL PROTECTION; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE IDENTIFICATION; LRRK2 GENE; MOUSE; NECROPTOSIS; NEK1 GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UBIQUITINATION; ANIMAL; CELL LINE; GENETICS; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; APOPTOSIS; CELL LINE; ENZYME ACTIVATION; LEUCINE-RICH REPEAT SERINE-THREONINE PROTEIN KINASE-2; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINATION;

EID: 85049008712     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1806973115     Document Type: Article

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