Legume biofortification is an underexploited strategy for combatting hidden hunger

Plant Cell and Environment

Volumn 42, Issue 1, 2019, Pages 52-70

  Rehman, Hafiz Mamoon ^a,c   Cooper, James William ^b   Lam, Hon Ming ^c   Yang, Seung Hwan ^a  

^a Chonnam National University   (South Korea)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

ecology; health; legumes; malnutrition; microbiome; nutrition; rhizosphere

Indexed keywords

AMINO ACID; BIOCHEMICAL COMPOSITION; BIOTECHNOLOGY; CROP IMPROVEMENT; ECOLOGICAL APPROACH; HEALTH STATUS; HUNGER; LEGUME; MALNUTRITION; PHYTOCHEMISTRY; PROTEIN; RHIZOSPHERE; TRACE ELEMENT;

BIOFORTIFICATION; FABACEAE; FOOD GRAIN; HUMAN; MALNUTRITION; NUTRITIONAL VALUE; PROCEDURES;

BIOFORTIFICATION; EDIBLE GRAIN; FABACEAE; HUMANS; MALNUTRITION; NUTRITIVE VALUE;

EID: 85052656076     PISSN: 01407791     EISSN: 13653040     Source Type: Journal    
DOI: 10.1111/pce.13368     Document Type: Review

References (186)

1. Abbo, S., Molina, C., Jungmann, R., Grusak, M. A., Berkovitch, Z., Reifen, R., … Reifen, R. (2005). Quantitative trait loci governing carotenoid concentration and weight in seeds of chickpea (Cicer arietinum L.). Theoretical and Applied Genetics, 111, 185–195
2. Adair, K. L., & Douglas, A. E. (2017). Making a microbiome: The many determinants of host-associated microbial community composition. Current Opinion in Microbiology, 35, 23–29
3. Amarakoon, D., Thavarajah, D., McPhee, K., & Thavarajah, P. (2012). Iron-, zinc-, and magnesium-rich field peas (Pisum sativum L.) with naturally low phytic acid: A potential food-based solution to global micronutrient malnutrition. Journal of Food Composition and Analysis, 27, 8–13
4. Ariza-Nieto, M., Blair, M. W., Welch, R. M., & Glahn, R. P. (2007). Screening of iron bioavailability patterns in eight bean (Phaseolus vulgaris L.) genotypes using the Caco-2 cell in vitro model. Journal of Agricultural and Food Chemistry, 55, 7950–7956
5. Armstrong, J., Dorosty, A. R., Reilly, J. J., & Emmett, P. M. (2003). Coexistence of social inequalities in undernutrition and obesity in preschool children: Population based cross sectional study. Archives of Disease in Childhood, 88, 671–675
6. Ates, D., Aldemir, S., Yagmur, B., Kahraman, A., Ozkan, H., Vandenberg, A., & Tanyolac, M. B. (2018). QTL mapping of genome regions controlling manganese uptake in lentil seed. G3: Genes, Genomes, Genetics, 8, 1409–1416
7. Ates, D., Sever, T., Aldemir, S., Yagmur, B., Temel, H. Y., Kaya, H. B., … Tanyolac, B. (2016). Identification QTLs controlling genes for Se uptake in lentil seeds. PLoS One, 11, e0149210
8. Atkinson, F. S., Foster-Powell, K., & Brand-Miller, J. C. (2008). International tables of glycemic index and glycemic load values: 2008. Diabetes Care, 31, 2281–2283
9. Bagga, S., Potenza, C., Ross, J., Martin, M. N., Leustek, T., & Sengupta-Gopalan, C. (2005). A transgene for high methionine protein is posttranscriptionally regulated by methionine. In Vitro Cellular & Developmental Biology. Plant, 41, 731–741
10. Baloch, S. T., Karakoy, A., Demirbas, F., Toklu, H., Ozkan, R., & Hatipoglu, F. (2014). Variation of some seed mineral contents in open pollinated faba bean (Vicia faba L.) landraces from Turkey. Turkish Journal of Agriculture and Forestry, 38, 591–602
11. Bazzano, L. A., Thompson, A. M., Tees, M. T., Nguyen, C. H., & Winham, D. M. (2011). Non-soy legume consumption lowers cholesterol levels: A meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases, 21, 94–103
12. Becerra-Tomas, N., Diaz-Lopez, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., … Salas-Salvado, J. (2018). Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study. Clinical Nutrition, 37, 906–913
13. Becker, R., Manteuffel, R., Neumann, D., & Scholz, G. (1998). Excessive iron accumulation in the pea mutants dgl and brz: Subcellular localization of iron and ferritin. Planta, 207, 217–223
14. Beebe, S., Gonzalez, A. V., & Rengifo, J. (2000). Research on trace minerals in the common bean. Food and Nutrition Bulletin, 21, 387–391
15. Beebe, S. E., Rojas-Pierce, M., Yan, X., Blair, M. W., Pedraza, F., Muñoz, F., … Lynch, J. P. (2006). Quantitative trait loci for root architecture traits correlated with phosphorus acquisition in common bean. Crop Science, 46, 413–423
16. Bertioli, D. J., Cannon, S. B., Froenicke, L., Huang, G., Farmer, A. D., Cannon, E. K., … Ozias-Akins, P. (2016). The genome sequences of Arachis duranensis and Arachis ipaensis, the diploid ancestors of cultivated peanut. Nature Genetics, 48, 438–446
17. Bilyeu, K. D., Zeng, P., Coello, P., Zhang, Z. J., Krishnan, H. B., Bailey, A., … Polacco, J. C. (2008). Quantitative conversion of phytate to inorganic phosphorus in soybean seeds expressing a bacterial phytase. Plant Physiology, 146, 468–477
18. Black, R. E., Victora, C. G., Walker, S. P., Bhutta, Z. A., Christian, P., De Onis, M., … Uauy, R. (2013). Maternal and child undernutrition and overweight in low-income and middle-income countries. The Lancet, 382, 427–451
19. Blair, M. W., & Izquierdo, P. (2012). Use of the advanced backcross-QTL method to transfer seed mineral accumulation nutrition traits from wild to Andean cultivated common beans. Theoretical and Applied Genetics, 125, 1015–1031
20. Blair, M. W., Medina, J. I., Astudillo, C., Rengifo, J., Beebe, S. E., Machado, G., & Graham, R. (2010). QTL for seed iron and zinc concentration and content in a Mesoamerican common bean (Phaseolus vulgaris L.) population. Theoretical and Applied Genetics, 121, 1059–1070
21. Blair, M. W., Sandoval, T. A., Caldas, G. V., Beebe, S. E., & Páez, M. I. (2009). Quantitative trait locus analysis of seed phosphorus and seed phytate content in a recombinant inbred line population of common bean. Crop Science, 49, 237–246
22. Bohn, L., Meyer, A. S., & Rasmussen, S. K. (2008). Phytate: Impact on environment and human nutrition. A Challenge for Molecular Breeding. Journal of Zhejiang University Science B, 9, 165–191
23. Bohra, A., Sahrawat, K. L., Kumar, S., Joshi, R., Parihar, A. K., Singh, U., … Singh, N. P. (2015). Genetics- and genomics-based interventions for nutritional enhancement of grain legume crops: Status and outlook. Journal of Applied Genetics, 56, 151–161
24. Bordage, S., Sullivan, S., Laird, J., Millar, A. J., & Nimmo, H. G. (2016). Organ specificity in the plant circadian system is explained by different light inputs to the shoot and root clocks. New Phytologist, 212, 136–149
25. Brinch-Pedersen, H., Hatzack, F., Stoger, E., Arcalis, E., Pontopidan, K., & Holm, P. B. (2006). Heat-stable phytases in transgenic wheat (Triticum aestivum L.): Deposition pattern, thermostability, and phytate hydrolysis. Journal of Agriculture and Food Chemistry, 54, 4624–4632
26. Burchi, F., Fanzo, J., & Frison, E. (2011). The role of food and nutrition system approaches in tackling hidden hunger. International Journal of Environmental Research and Public Health, 8, 358–373
27. Campion, B., Sparvoli, F., Doria, E., Tagliabue, G., Galasso, I., Fileppi, M., … Nielsen, E. (2009). Isolation and characterisation of an lpa (low phytic acid) mutant in common bean (Phaseolus vulgaris L.). Theoretical and Applied Genetics, 118, 1211–1221
28. Castenmiller, J. J., West, C. E., Linssen, J. P., van het Hof, K. H., & Voragen, A. G. (1999). The food matrix of spinach is a limiting factor in determining the bioavailability of beta-carotene and to a lesser extent of lutein in humans. Journal of Nutrition, 129, 349–355
29. Castro-Guerrero, N. A., Isidra-Arellano, M. C., Mendoza-Cozatl, D. G., & Valdés-López, O. (2016). Common bean: A legume model on the rise for unraveling responses and adaptations to iron, zinc, and phosphate deficiencies. Frontiers in Plant Science, 7, 600
30. Chen, R., Xue, G., Chen, P., Yao, B., Yang, W., Ma, Q., … Shi, J. (2008). Transgenic maize plants expressing a fungal phytase gene. Transgenic Research, 17, 633–643
31. Chiera, J. M., Finer, J. J., & Grabau, E. A. (2004). Ectopic expression of a soybean phytase in developing seeds of Glycine max to improve phosphorus availability. Plant Molecular Biology, 56, 895–904
32. Christenhusz, M. J. M., & Byng, J. W. (2016). The number of known plants species in the world and its annual increase. Phytotaxa, 261, 201–217
33. Cichy, K. A., Caldas, G. V., Snapp, S. S., & Blair, M. W. (2009). QTL analysis of seed iron, zinc, and phosphorus levels in an Andean bean population. Crop Science, 49, 1742–1750
34. Clemente, A., Arques, M. C., Dalmais, M., Le Signor, C., Chinoy, C., Olias, R., … Domoney, C. (2015). Eliminating anti-nutritional plant food proteins: The case of seed protease inhibitors in pea. PLoS One, 10, e0134634
35. Clemente, A., & Olias, R. (2017). Beneficial effects of legumes in gut health. Current Opinion in Food Science, 14, 32–36
36. Connorton, J. M., Jones, E. R., Rodriguez-Ramiro, I., Fairweather-Tait, S., Uauy, C., & Balk, J. (2017). Vacuolar iron transporter TaVIT2 transports Fe and Mn and is effective for biofortification. Plant Physiology, 174, 2434–2444
37. Cowling, W. A., Stefanova, K. T., Beeck, C. P., Nelson, M. N., Hargreaves, B. L., Sass, O., … Siddique, K. H. (2015). Using the animal model to accelerate response to selection in a self-pollinating crop. G3: Genes, Genomes, Genetics, 5, 1419–1428
38. Crépon, K., Marget, P., Peyronnet, C., Carrouée, B., Arese, P., & Duc, G. (2010). Nutritional value of faba bean (Vicia faba L.) seeds for feed and food. Field Crops Research, 115, 329–339
39. Daly, D. H., Velivelli, S. L. S., & Prestwich, B. D. (2017). The role of soil microbes in crop biofortification. In V. S. Meena, P. K. Mishra, J. K. Bisht, & A. Pattanayak (Eds.), Agriculturally important microbes for sustainable agriculture (pp. 333–356). Singapore: Springer Nature
40. De Steur, H., Demont, M., Gellynck, X., & Stein, A. J. (2017). The social and economic impact of biofortification through genetic modification. Current Opinion in Biotechnology, 44, 161–168
41. De Vega, J. J., Ayling, S., Hegarty, M., Kudrna, D., Goicoechea, J. L., Ergon, A., … Skot, L. (2015). Red clover (Trifolium pratense L.) draft genome provides a platform for trait improvement. Scientific Reports, 5, 17394
42. Debabrata, D., Monika, S., & Bibekananda, D. (2014). Food quality of rural poor in India: A case study of Orissa and Bihar. International Journal of Innovation and Applied Studies, 6, 622–628
43. Delange, F., & Lecomte, P. (2000). Iodine supplementation: Benefits outweigh risks. Drug Safety, 22, 89–95
44. Delhaize, E. (1996). A metal-accumulator mutant of Arabidopsis thaliana. Plant Physiology, 111, 849–855
45. Dewey, K. G., & Begum, K. (2011). Long-term consequences of stunting in early life. Maternal & Child Nutrition, 7, 5–18
46. Diapari, M., Sindhu, A., Bett, K., Deokar, A., Warkentin, T. D., & Tar'an, B. (2014). Genetic diversity and association mapping of iron and zinc concentrations in chickpea (Cicer arietinum L.). Genome, 57, 459–468
47. Diapari, M., Sindhu, A., Warkentin, T. D., Bett, K., & Tar'an, B. (2015). Population structure and marker-trait association studies of iron, zinc and selenium concentrations in seed of field pea (Pisum sativum L.). Molecular Breeding, 35, 30
48. Doley, J. (2015). Chapter 23. Minerals and older adults. In R. R. Watson (Ed.), Foods and dietary supplements in the prevention and treatment of disease in older adults (pp. 239–252). London, San Diego CA, Waltham MA, Oxford: Academic Press
49. Doria, E., Campion, B., Sparvoli, F., Tava, A., & Nielsen, E. (2012). Anti-nutrient components and metabolites with health implications in seeds of 10 common bean (Phaseolus vulgaris L. and Phaseolus lunatus L.) landraces cultivated in southern Italy. Journal of Food Composition and Analysis, 26, 72–80
50. Douchkov, D., Gryczka, C., Stephan, U. W., Hell, R., & Bäumlein, H. (2005). Ectopic expression of nicotianamine synthase genes results in improved iron accumulation and increased nickel tolerance in transgenic tobacco. Plant, Cell & Environment, 28, 365–374
51. Duranti, M., & Gius, C. (1997). Legume seeds: Protein content and nutritional value. Field Crops Research, 53, 31–45
52. FAO, IFAD, UNICEF W. and W (2010). The state of food insecurity in the world: Addressing food insecurity in protracted crises. Rome: FAO
53. FAO, IFAD, UNICEF W. and W (2017). The state of food security and nutrition in the world. Building resilience for peace and food security. Rome: FAO
54. Finn, S. (2014). Nutrition insecurity and malnutrition in developed countries. In S. Sanders, & T. Hicklin (Eds.), Addressing malnutrition to improve Global Health (pp. 8–10). Washington, DC: Science/AAAS
55. Flachowsky, G., Chesson, A., & Aulrich, K. (2005). Animal nutrition with feeds from genetically modified plants. Archives of Animal Nutrition, 59, 1–40
56. Foyer, C. H., Lam, H. M., Nguyen, H. T., Siddique, K. H., Varshney, R. K., Colmer, T. D., … Considine, M. J. (2016). Neglecting legumes has compromised human health and sustainable food production. Nature Plants, 2, 16112
57. Gebrelibanos Tesfaye, D., Raghavendra, Y., & Sintayeyu, B. M. (2013). Nutritional and health implications of legumes. International Journal of Pharmaceutical Sciences and Research, 4, 1269–1279
58. Godfray, H. C. J., Beddington, J. R., Crute, I. R., Haddad, L., Lawrence, D., Muir, J. F., … Toulmin, C. (2010). Food security: The challenge of feeding 9 billion people. Science, 327, 812–818
59. Gopalakrishnan, S., Vadlamudi, S., Samineni, S., & Sameer Kumar, C. V. (2016). Plant growth-promotion and biofortification of chickpea and pigeonpea through inoculation of biocontrol potential bacteria, isolated from organic soils. Springerplus, 5, 1882
60. Graham, R. D., Welch, R. M., Saunders, D. A., Ortiz-Monasterio, I., Bouis, H. E., Bonierbale, M., … Twomlow, S. (2007). Nutritious subsistence food systems. Advances in Agronomy, 92, 1–74
61. Grusak, M. A. (2000). Strategies for improving the iron nutritional quality of seed crops: Lessons learned from the study of unique iron-hyperaccumulating pea mutants. Pisum Genetics, 32, 1–5
62. Gupta, D. S., Thavarajah, D., McGee, R. J., Coyne, C. J., Kumar, S., & Thavarajah, P. (2016). Genetic diversity among cultivated and wild lentils for iron, zinc, copper, calcium and magnesium concentrations. Australian Journal of Crop Science, 10, 1381–1387
63. Guzmán-Maldonado, S. H., Martínez, O., Acosta-Gallegos, J. A., Guevara-Lara, F., & Paredes-López, O. (2003). Putative quantitative trait loci for physical and chemical components of common bean. Crop Science, 43, 1029–1035
64. Ha, V., Sievenpiper, J. L., de Souza, R. J., Jayalath, V. H., Mirrahimi, A., Agarwal, A., … Jenkins, D. J. A. (2014). Effect of dietary pulse intake on established therapeutic lipid targets for cardiovascular risk reduction: A systematic review and meta-analysis of randomized controlled trials. CMAJ: Canadian Medical Association Journal, 186, E252–E262
65. Hacquard, S., Garrido-Oter, R., Gonzalez, A., Spaepen, S., Ackermann, G., Lebeis, S., … Schulze-Lefert, P. (2015). Microbiota and host nutrition across plant and animal kingdoms. Cell Host & Microbe, 17, 603–616
66. Hall, C., Hillen, C., & Garden Robinson, J. (2016). Composition, nutritional value, and health benefits of pulses. Cereal Chemistry Journal, 94, 11–31
67. Hane, J. K., Ming, Y., Kamphuis, L. G., Nelson, M. N., Garg, G., Atkins, C. A., … Singh, K. B. (2017). A comprehensive draft genome sequence for lupin (Lupinus angustifolius), an emerging health food: Insights into plant-microbe interactions and legume evolution. Plant Biotechnology Journal, 15, 318–330
68. Hartman, K., van der Heijden, M. G. A., Roussely-Provent, V., Walser, J.-C., & Schlaeppi, K. (2017). Deciphering composition and function of the root microbiome of a legume plant. Microbiome, 5, 2
69. Herman, E. M., & Schmidt, M. A. (2016). The Potential for Engineering Enhanced Functional-Feed Soybeans for Sustainable Aquaculture Feed. Frontiers in Plant Science, 7, 440–69. https://doi.org/10.3389/fpls.2016.00440
70. Hermsdorff, H. H., Zulet, M. A., Abete, I., & Martinez, J. A. (2011). A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects. European Journal of Nutrition, 50, 61–69
71. Ho, E. (2004). Zinc deficiency, DNA damage and cancer risk. Journal of Nutritional Biochemistry, 15, 572–578
72. Hong, C. Y., Cheng, K. J., Tseng, T. H., Wang, C. S., Liu, L. F., & Yu, S. M. (2004). Production of two highly active bacterial phytases with broad pH optima in germinated transgenic rice seeds. Transgenic Research, 13, 29–39
73. Hornykiewicz, O. (2002). L-DOPA: From a biologically inactive amino acid to a successful therapeutic agent. Amino Acids, 23, 65–70
74. Hubbard, C. J., Brock, M. T., van Diepen, L. T., Maignien, L., Ewers, B. E., & Weinig, C. (2017). The plant circadian clock influences rhizosphere community structure and function. The ISME Journal, 400–410
75. Ibrikci, H., Knewtson, S. J., & Grusak, M. A. (2003). Chickpea leaves as a vegetable green for humans: Evaluation of mineral composition. Journal of the Science of Food and Agriculture, 83, 945–950
76. Iqbal, A., Khalil, I. A., Ateeq, N., & Sayyar Khan, M. (2006). Nutritional quality of important food legumes. Food Chemistry, 97, 331–335
77. Islam, F. M. A., Basford, K. E., Redden, R. J., Gonzalez, A. V., Kroonenberg, P. M., & Beebe, S. (2002). Genetic variability in cultivated common bean beyond the two major gene pools. Genetic Resources and Crop Evolution, 49, 271–283
78. Janila, P., Nigam, S. N., Abhishek, R., Anil Kumar, V., Manohar, S. S., & Venuprasad, R. (2015). Iron and zinc concentrations in peanut (Arachis hypogaea L.) seeds and their relationship with other nutritional and yield parameters. The Journal of Agricultural Science, 153, 975–994
79. Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., & Forman, D. (2011). Global cancer statistics. CA: A Cancer Journal for Clinicians, 61, 69–90
80. Jenkins, D. J., Kendall, C. W., Augustin, L. S., Mitchell, S., Sahye-Pudaruth, S., Blanco Mejia, S., … Josse, R. G. (2012). Effect of legumes as part of a low glycemic index diet on glycemic control and cardiovascular risk factors in type 2 diabetes mellitus: A randomized controlled trial. Archives of Internal Medicine, 172, 1653–1660
81. Kang, Y. J., Kim, S. K., Kim, M. Y., Lestari, P., Kim, K. H., Ha, B. K., … Lee, S. H. (2014). Genome sequence of mungbean and insights into evolution within Vigna species. Nature Communications, 5, 5443
82. Kang, Y. J., Satyawan, D., Shim, S., Lee, T., Lee, J., Hwang, W. J., … Lee, S. H. (2015). Draft genome sequence of adzuki bean, Vigna angularis. Scientific Reports, 5, 8069
83. Karakoy, T., Erdem, H., Baloch, F. S., Toklu, F., Eker, S., Kilian, B., & Ozkan, H. (2012). Diversity of macro- and micronutrients in the seeds of lentil landraces. Scientific World Journal, 2012, 710412, 1–9
84. Katuuramu, D. N., Hart, J. P., Porch, T. G., Grusak, M. A., Glahn, R. P., & Cichy, K. A. (2018). Genome-wide association analysis of nutritional composition-related traits and iron bioavailability in cooked dry beans (Phaseolus vulgaris L.). Molecular Breeding, 38, 44
85. Khandelwal, S., & Kurpad, A. (2014). Nurturing public health nutrition education in India. European Journal of Clinical Nutrition, 68, 539–540
86. Khazaei, H., Podder, R., Caron, C. T., Kundu, S. S., Diapari, M., Vandenberg, A., & Bett, K. E. (2017). Marker-trait association analysis of iron and zinc concentration in lentil (Lens culinaris Medik.) seeds. Plant Genome, 10
87. King, K. E., Peiffer, G. A., Reddy, M., Lauter, N., Lin, S. F., Cianzio, S., & Shoemaker, R. C. (2013). Mapping of iron and zinc quantitative trait loci in soybean for association to iron deficiency chlorosis resistance. Journal of Plant Nutrition, 36, 2132–2153
88. Klein, M. A., & Grusak, M. A. (2009). Identification of nutrient and physical seed trait QTL in the model legume Lotus japonicus. Genome, 52, 677–691
89. Klein, M. A., López-Millán, A.-F., & Grusak, M. A. (2012). Quantitative trait locus analysis of root ferric reductase activity and leaf chlorosis in the model legume, Lotus japonicus. Plant and Soil, 351, 363–376
90. Kumar, J., Gupta, D. S., Kumar, S., Gupta, S., & Singh, N. P. (2016). Current knowledge on genetic biofortification in lentil. Journal of Agriculture and Food Chemistry, 64, 6383–6396
91. Kushi, L. H., Meyer, K. A., & Jacobs, D. R. Jr. (1999). Cereals, legumes, and chronic disease risk reduction: Evidence from epidemiologic studies. American Journal of Clinical Nutrition, 70, 451s–458s
92. Kwon, S.-J., Brown, A. F., Hu, J., McGee, R., Watt, C., Kisha, T., … Coyne, C. J. (2012). Genetic diversity, population structure and genome-wide marker-trait association analysis emphasizing seed nutrients of the USDA pea (Pisum sativum L.) core collection. Genes & Genomics, 34, 305–320
93. La Frano, M. R., Woodhouse, L. R., Burnett, D. J., & Burri, B. J. (2013). Biofortified cassava increases beta-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women. British Journal of Nutrition, 110, 310–320
94. Li, H., Li, J., Shen, Y., Wang, J., & Zhou, D. (2017). Legume consumption and all-cause and cardiovascular disease mortality. BioMed Research International, 2017, 6
95. Lin, S., Cianzio, S., & Shoemaker, R. (1997). Mapping genetic loci for iron deficiency chlorosis in soybean. Molecular Breeding, 3, 219–229
96. Losso, J. N. (2008). The biochemical and functional food properties of the Bowman–Birk inhibitor. Critical Reviews in Food Science and Nutrition, 48, 94–118
97. Lovegrove, A., Edwards, C. H., De Noni, I., Patel, H., El, S. N., Grassby, T., … Shewry, P. R. (2017). Role of polysaccharides in food, digestion, and health. Critical Reviews in Food Science and Nutrition, 57, 237–253
98. Lugtenberg, B., & Kamilova, F. (2009). Plant-growth-promoting rhizobacteria. Annual Review of Microbiology, 63, 541–556
99. Luis, L., Gilles, B., Bruna, G., Juliette, A., & Josette, G. (2014). 50 year trends in nitrogen use efficiency of world cropping systems: The relationship between yield and nitrogen input to cropland. Environmental Research Letters, 9, 105011
100. Ma, Y., Coyne, C. J., Grusak, M. A., Mazourek, M., Cheng, P., Main, D., & McGee, R. J. (2017). Genome-wide SNP identification, linkage map construction and QTL mapping for seed mineral concentrations and contents in pea (Pisum sativum L.). BMC Plant Biology, 17, 43
101. Mamidi, S., Lee, R. K., Goos, J. R., & McClean, P. E. (2014). Genome-wide association studies identifies seven major regions responsible for iron deficiency chlorosis in soybean (Glycine max). PLoS One, 9, e107469
102. Martins, V. J., Toledo Florêncio, T. M., Grillo, L. P., Do Carmo P Franco, M., Martins, P. A., Clemente, A. P. G., … Sawaya, A. L. (2011). Long-lasting effects of undernutrition. International Journal of Environmental Research and Public Health, 8, 1817–1846
103. Mayer, J. E., Pfeiffer, W. H., & Beyer, P. (2008). Biofortified crops to alleviate micronutrient malnutrition. Current Opinion in Plant Biology, 11, 166–170
104. McClung, C. R. (2006). Plant circadian rhythms. The Plant Cell, 18, 792–803
105. Meng, L., Zhang, A., Wang, F., Han, X., Wang, D., & Li, S. (2015). Arbuscular mycorrhizal fungi and rhizobium facilitate nitrogen uptake and transfer in soybean/maize intercropping system. Frontiers in Plant Science, 6
106. Mirmiran, P., Bahadoran, Z., Golzarand, M., Shiva, N., & Azizi, F. (2012). Association between dietary phytochemical index and 3-year changes in weight, waist circumference and body adiposity index in adults: Tehran Lipid and Glucose Study. Nutrition and Metabolism, 9, 108
107. Morton, J. F. (2007). The impact of climate change on smallholder and subsistence agriculture. Proceedings of the National Academy of Sciences, 104, 19680–19685
108. Nair, R. M., Thavarajah, D., Thavarajah, P., Giri, R. R., Ledesma, D., Yang, R.-Y., … Keatinge, J. D. H. (2015). Mineral and phenolic concentrations of mungbean [Vigna radiata (L.) R. Wilczek var. radiata] grown in semi-arid tropical India. Journal of Food Composition and Analysis, 39, 23–32
109. Nair, R. M., Yang, R. Y., Easdown, W. J., Thavarajah, D., Thavarajah, P., Hughes, J., & Keatinge, J. D. (2013). Biofortification of mungbean (Vigna radiata) as a whole food to enhance human health. Journal of the Science of Food and Agriculture, 93, 1805–1813
110. Nimni, M. E., Han, B., & Cordoba, F. (2007). Are we getting enough sulfur in our diet? Nutrition and Metabolism, 4
111. Nothlings, U., Murphy, S. P., Wilkens, L. R., Henderson, B. E., & Kolonel, L. N. (2007). Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: The Multiethnic Cohort Study. American Journal of Clinical Nutrition, 86, 1495–1501
112. Ochoa, I. E., Blair, M. W., & Lynch, J. P. (2006). QTL analysis of adventitious root formation in common bean under contrasting phosphorus availability. Crop Science, 46, 1609–1621
113. Paine, J. A., Shipton, C. A., Chaggar, S., Howells, R. M., Kennedy, M. J., Vernon, G., … Drake, R. (2005). Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nature Biotechnology, 23, 482–487
114. Papanikolaou, Y., & Fulgoni, V. L. (2008). Bean consumption is associated with greater nutrient intake, reduced systolic blood pressure, lower body weight, and a smaller waist circumference in adults: Results from the National Health and Nutrition Examination Survey 1999-2002. Journal of the American College of Nutrition, 27, 569–576
115. Parween, S., Nawaz, K., Roy, R., Pole, A. K., Venkata Suresh, B., Misra, G., … Chattopadhyay, D. (2015). An advanced draft genome assembly of a desi type chickpea (Cicer arietinum L.). Scientific Reports, 5, 12806
116. Paustian, K., Lehmann, J., Ogle, S., Reay, D., Robertson, G. P., & Smith, P. (2016). Climate-smart soils. Nature, 532, 49–57
117. Peiffer, G. A., King, K. E., Severin, A. J., May, G. D., Cianzio, S. R., Lin, S. F., … Shoemaker, R. C. (2012). Identification of candidate genes underlying an iron efficiency quantitative trait locus in soybean. Plant Physiology, 158, 1745–1754
118. Pellegrino, E., & Bedini, S. (2014). Enhancing ecosystem services in sustainable agriculture: Biofertilization and biofortification of chickpea (Cicer arietinum L.) by arbuscular mycorrhizal fungi. Soil Biology and Biochemistry, 68, 429–439
119. Pfeiffer, W. H., & McClafferty, B. (2007). HarvestPlus: Breeding crops for better nutrition. Crop Science, 47, S-88–S-105
120. Pinheiro, C., Baeta, J. P., Pereira, A. M., Domingues, H., & Ricardo, C. P. (2010). Diversity of seed mineral composition of Phaseolus vulgaris L. germplasm. Journal of Food Composition and Analysis, 23, 319–325
121. Ponstein, A. S., Bade, J. B., Verwoerd, T. C., Molendijk, L., Storms, J., Beudeker, R. F., & Pen, J. (2002). Stable expression of phytase (phyA) in canola (Brassica napus) seeds: Towards a commercial product. Molecular Breeding, 10, 31–44
122. Prathet, P., Somta, P., & Srinives, P. (2012). Mapping QTL conferring resistance to iron deficiency chlorosis in mungbean [Vigna radiata (L.) Wilczek]. Field Crops Research, 137, 230–236
123. Raboy, V., & Dickinson, D. B. (1984). Effect of phosphorus and zinc nutrition on soybean seed phytic acid and zinc. Plant Physiology, 75, 1094–1098
124. Raboy, V., Dickinson, D. B., & Below, F. E. (1984). Variation in seed total phosphorus, phytic acid, zinc, calcium, magnesium, and protein among lines of Glycine max and G. soja1. Crop Science, 24, 431–434
125. Rashid, M. I., Mujawar, L. H., Shahzad, T., Almeelbi, T., Ismail, I. M. I., & Oves, M. (2016). Bacteria and fungi can contribute to nutrients bioavailability and aggregate formation in degraded soils. Microbiological Research, 183, 26–41
126. Ray, H., Bett, K., Tar'an, B., Vandenberg, A., Thavarajah, D., & Warkentin, T. (2014). Mineral micronutrient content of cultivars of field pea, chickpea, common bean, and lentil grown in Saskatchewan, Canada. Crop Science, 54, 1698–1708
127. Rebello, C. J., Greenway, F. L., & Finley, J. W. (2014). A review of the nutritional value of legumes and their effects on obesity and its related co-morbidities. Obesesity Reviews, 15, 392–407
128. Rogers, E. E., & Guerinot, M. L. (2002). FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis. Plant Cell, 14, 1787–1799
129. Roy, F., Boye, J. I., & Simpson, B. K. (2010). Bioactive proteins and peptides in pulse crops: Pea, chickpea and lentil. Food Research International, 43, 432–442
130. Rychlik, M., Englert, K., Kapfer, S., & Kirchhoff, E. (2007). Folate contents of legumes determined by optimized enzyme treatment and stable isotope dilution assays. Journal of Food Composition and Analysis, 20, 411–419
131. Saalbach, I., Waddell, D., Pickardt, T., Schieder, O., & Müntz, K. (1995). Stable expression of the sulphur-rich 2S albumin gene in transgenic Vicia narbonensis increases the methionine content of seeds. Journal of Plant Physiology, 145, 674–681
132. Sandberg, A. S. (2002). Bioavailability of minerals in legumes. British Journal of Nutrition, 88, S281–S285
133. Sankaran, R. P., Huguet, T., & Grusak, M. A. (2009). Identification of QTL affecting seed mineral concentrations and content in the model legume Medicago truncatula. Theoretical and Applied Genetics, 119, 241–253
134. Santos, C. A., & Boiteux, L. S. (2013). Breeding biofortified cowpea lines for semi-arid tropical areas by combining higher seed protein and mineral levels. Genetics and Molecular Research, 12, 6782–6789
135. Sathya, A., Vijayabharathi, R., Srinivas, V., & Gopalakrishnan, S. (2016). Plant growth-promoting actinobacteria on chickpea seed mineral density: An upcoming complementary tool for sustainable biofortification strategy. 3 Biotech, 6, 138
136. Sato, S., Nakamura, Y., Kaneko, T., Asamizu, E., Kato, T., Nakao, M., … Tabata, S. (2008). Genome structure of the legume, Lotus japonicus. DNA Research, 15, 227–239
137. Schloss, P. D., & Handelsman, J. (2006). Toward a census of bacteria in soil. PLoS Computational Biology, 2, e92
138. Schmutz, J., Cannon, S. B., Schlueter, J., Ma, J., Mitros, T., Nelson, W., … Jackson, S. A. (2010). Genome sequence of the palaeopolyploid soybean. Nature, 463, 178–183
139. Schmutz, J., McClean, P. E., Mamidi, S., Wu, G. A., Cannon, S. B., Grimwood, J., … Jackson, S. A. (2014). A reference genome for common bean and genome-wide analysis of dual domestications. Nature Genetics, 46, 707–713
140. Shlichta, J. G., Glauser, G., & Benrey, B. (2014). Variation in cyanogenic glycosides across populations of wild lima beans (Phaseolus lunatus) has no apparent effect on bruchid beetle performance. Journal of Chemical Ecology, 40, 468–475
141. Shunmugam, A., Bock, C., Arganosa, G., Georges, F., Gray, G., & Warkentin, T. (2015). Accumulation of phosphorus-containing compounds in developing seeds of low-phytate pea (Pisum sativum L.) Mutants. Plants, 4, 1–26
142. Singh, A., Sharma, V. K., Dikshit, H. K., Singh, D., Aski, M., Prakash, P., … Sarker, A. (2017). Microsatellite marker-based genetic diversity analysis of elite lentil lines differing in grain iron and zinc concentration. Journal of Plant Biochemistry and Biotechnology, 26, 199–207
143. Singh, A. P., Sarkar, S., Tripathi, M., & Rajender, S. (2013). Mucuna pruriens and its major constituent L-DOPA recover spermatogenic loss by combating ROS, loss of mitochondrial membrane potential and apoptosis. PLoS One, 8, e54655
144. Singh, B., Singh, J. P., Kaur, A., & Singh, N. (2017). Phenolic composition and antioxidant potential of grain legume seeds: A review. Food Research International, 101, 1–16
145. Singh, J. S., Pandey, V. C., & Singh, D. P. (2011). Efficient soil microorganisms: A new dimension for sustainable agriculture and environmental development. Agriculture, Ecosystems & Environment, 140, 339–353
146. Singhal, P., Kaushik, G., & Mathur, P. (2014). Antidiabetic potential of commonly consumed legumes: A review. Critical Reviews in Food Science and Nutrition, 54, 655–672
147. Smrkolj, P., Stibilj, V., Kreft, I., & Kapolna, E. (2005). Selenium species determination in selenium-enriched pumpkin (Cucurbita pepo L.) seeds by HPLC-UV-HG-AFS. Analytical Sciences, 21, 1501–1504
148. Susser, E. (2012). Relation of childhood malnutrition to adult mental disorders. American Journal of Psychiatry, 169, 777–779
149. Tabe, L. M., & Droux, M. (2002). Limits to sulfur accumulation in transgenic lupin seeds expressing a foreign sulfur-rich protein. Plant Physiology, 128, 1137–1148
150. Takahashi, M., Nakanishi, H., Kawasaki, S., Nishizawa, N. K., & Mori, S. (2001). Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes. Nature Biotechnology, 19, 466–469
151. Thavarajah, D., & Thavarajah, P. (2012). Evaluation of chickpea (Cicer arietinum L.) micronutrient composition: Biofortification opportunities to combat global micronutrient malnutrition. Food Research International, 49(2012), 99–104
152. Thavarajah, D., Thavarajah, P., Sarker, A., Materne, M., Vandemark, G., Shrestha, R., … Vandenberg, A. (2011). A global survey of effects of genotype and environment on selenium concentration in lentils (Lens culinaris L.): Implications for nutritional fortification strategies. Food Chemistry, 125(2011), 72–76
153. Thavarajah, D., Warkentin, T., & Vandenberg, A. (2010). Natural enrichment of selenium in Saskatchewan field peas (Pisum sativum L.). Canadian Journal of Plant Science, 90, 383–389
154. Trinidad, T. P., Mallillin, A. C., Valdez, D. H., Loyola, A. S., Askali-Mercado, F. C., Castillo, J. C., … Chua, M. T. (2006). Dietary fiber from coconut flour: A functional food. Innovative Food Science & Emerging Technologies, 7, 309–317
155. United Nations General Assembly (2001). Road map towards the implementation of the United Nations Millennium Declaration, A/56/326 (6th September 2001) available from undocs.org/A/56/326
156. United Nations General Assembly (2014). Resolution 68/231, International Year of Pulses, 2016 A/RES/68/231 (7th February 2014), available from undocs.org/A/RES/68/231
157. Upadhyaya, H. D., Bajaj, D., Das, S., Kumar, V., Gowda, C. L., Sharma, S., … Parida, S. K. (2016). Genetic dissection of seed-iron and zinc concentrations in chickpea. Scientific Reports, 6, 24050
158. USDA (2016). USDA national nutrient database for standard reference release 28. National Nutrient Database for Standard Reference
159. van der Heijden, M. G., Bardgett, R. D., & van Straalen, N. M. (2008). The unseen majority: Soil microbes as drivers of plant diversity and productivity in terrestrial ecosystems. Ecology Letters, 11, 296–310
160. Van Horn, L., McCoin, M., Kris-Etherton, P. M., Burke, F., Carson, J. A., Champagne, C. M., … Sikand, G. (2008). The evidence for dietary prevention and treatment of cardiovascular disease. Journal of the American Dietetic Association, 108, 287–331
161. Varshney, R. K. (2016). Exciting journey of 10 years from genomes to fields and markets: Some success stories of genomics-assisted breeding in chickpea, pigeonpea and groundnut. Plant Science, 242, 98–107
162. Varshney, R. K., Bansal, K. C., Aggarwal, P. K., Datta, S. K., & Craufurd, P. Q. (2011). Agricultural biotechnology for crop improvement in a variable climate: Hope or hype? Trends in Plant Science, 16, 363–371
163. Varshney, R. K., Chen, W., Li, Y., Bharti, A. K., Saxena, R. K., Schlueter, J. A., … Jackson, S. A. (2011). Draft genome sequence of pigeonpea (Cajanus cajan), an orphan legume crop of resource-poor farmers. Nature Biotechnology, 30, 83–89
164. Varshney, R. K., Close, T. J., Singh, N. K., Hoisington, D. A., & Cook, D. R. (2009). Orphan legume crops enter the genomics era! Current Opinion in Microbiology, 12, 202–210
165. Varshney, R. K., Song, C., Saxena, R. K., Azam, S., Yu, S., Sharpe a, G., … Cook, D. R. (2013). Draft genome sequence of chickpea (Cicer arietinum) provides a resource for trait improvement. Nature Biotechnology, 31, 240–246
166. Vasconcelos, M., Eckert, H., Arahana, V., Graef, G., Grusak, M. A., & Clemente, T. (2006). Molecular and phenotypic characterization of transgenic soybean expressing the Arabidopsis ferric chelate reductase gene, FRO2. Planta, 224, 1116–1128
167. Vaz Patto, M. C., Amarowicz, R., Aryee, A. N. A., Boye, J. I., Chung, H.-J., Martín-Cabrejas, M. A., & Domoney, C. (2015). Achievements and challenges in improving the nutritional quality of food legumes. Critical Reviews in Plant Sciences, 34, 105–143
168. Venn, B. J., & Mann, J. I. (2004). Cereal grains, legumes and diabetes. European Journal of Clinical Nutrition, 58, 1443–1461
169. von Grebmer, K., Bernstein, J., Nabarro, D., Prasai, N., Amin, S., Yohannes, Y., … Thompson, J. (2016). 2016 Global hunger index: getting to zero hunger. Bonn Washington, DC and Dublin: Welthungerhilfe, International Food Policy Research Institute, and Concern Worldwide
170. Walker, D. R., Scaboo, A. M., Pantalone, V. R., Wilcox, J. R., & Boerma, H. R. (2006). Genetic mapping of loci associated with seed phytic acid content in CX1834-1-2 soybean. Crop Science, 46, 390–397
171. Wang, N., & Daun, J. K. (2004). Effect of variety and crude protein content on nutrients and certain antinutrients in field peas (Pisum sativum). Journal of the Science of Food and Agriculture, 84, 1021–1029
172. Wang, N., Hatcher, D. W., Toews, R., & Gawalko, E. J. (2009). Influence of cooking and dehulling on nutritional composition of several varieties of lentils (Lens culinaris). LWT - Food Science and Technology, 42, 842–848
173. Wang, T. L., Domoney, C., Hedley, C. L., Casey, R., & Grusak, M. A. (2003). Can we improve the nutritional quality of legume seeds? Plant Physiology, 131, 886–891
174. Wardle, D. A., Bardgett, R. D., Klironomos, J. N., Setala, H., van der Putten, W. H., & Wall, D. H. (2004). Ecological linkages between aboveground and belowground biota. Science, 304, 1629–1633
175. Welch, R. M., & Graham, R. D. (2005). Agriculture: The real nexus for enhancing bioavailable micronutrients in food crops. Journal of Trace Elements in Medicine and Biology, 18, 299–307
176. White, P. J. (2016). Selenium accumulation by plants. Annals of Botany, 117, 217–235
177. White, P. J., & Broadley, M. R. (2005). Biofortifying crops with essential mineral elements. Trends in Plant Science, 10, 586–593
178. White, P. J., & Broadley, M. R. (2009). Biofortification of crops with seven mineral elements often lacking in human diets—Iron, zinc, copper, calcium, magnesium, selenium and iodine. New Phytologist, 182, 49–84
179. Winham, D. M., Hutchins, A. M., & Johnston, C. S. (2007). Pinto bean consumption reduces biomarkers for heart disease risk. Journal of the American College of Nutrition, 26, 243–249
180. Yan, X., Liao, H., Beebe, S. E., Blair, M. W., & Lynch, J. P. (2004). QTL mapping of root hair and acid exudation traits and their relationship to phosphorus uptake in common bean. Plant and Soil, 265, 17–29
181. Yang, F., Chen, L., Hu, Q., & Pan, G. (2003). Effect of the application of selenium on selenium content of soybean and its products. Biological Trace Element Research, 93, 249–256
182. Yang, J., Kloepper, J. W., & Ryu, C. M. (2009). Rhizosphere bacteria help plants tolerate abiotic stress. Trends in Plant Science, 14, 1–4
183. Yigzaw, Y., Larsson, N., Gorton, L., Ruzgas, T., & Solomon, T. (2001). Liquid chromatographic determination of total and beta-N-oxalyl-L-alpha, beta-diaminopropionic acid in Lathyrus sativus seeds using both refractive index and bioelectrochemical detection. Journal of Chromatography A, 929, 13–21
184. Young, N. D., Debelle, F., Oldroyd, G. E., Geurts, R., Cannon, S. B., Udvardi, M. K., … Roe, B. A. (2011). The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature, 480, 520–524
185. Zhang, W., & Popovich, D. G. (2009). Chemical and biological characterization of oleanane triterpenoids from soy. Molecules, 14, 2959–2975
186. Zia-Ul-Haq, M., Iqbal, S., Ahmad, S., Imran, M., Niaz, A., & Bhanger, M. I. (2007). Nutritional and compositional study of desi chickpea (Cicer arietinum L.) cultivars grown in Punjab, Pakistan. Food Chemistry, 105, 1357–1363