메뉴 건너뛰기




Volumn 11, Issue 12, 2017, Pages 1491-1503

Cellular and molecular mediators of intestinal fibrosis

Author keywords

Chemokine; Extracellular matrix; Fibroblast; Growth factor; Inflammatory bowel disease; Interleukin; Intestinal fibrosis; Myofibroblast

Indexed keywords

ACTIVIN; ANTIFIBRINOLYTIC AGENT; CHEMOKINE; CONNECTIVE TISSUE GROWTH FACTOR; CYTOKINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR; SIGNAL PEPTIDE;

EID: 85042806014     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1016/j.crohns.2014.09.008     Document Type: Review
Times cited : (126)

References (165)
  • 1
    • 0034997565 scopus 로고    scopus 로고
    • Inflammation location, but not type, determines the increase in TGF-beta1 and IGF-1 expression and collagen deposition in IBD intestine
    • Lawrance IC, Maxwell L, Doe W. Inflammation location, but not type, determines the increase in TGF-beta1 and IGF-1 expression and collagen deposition in IBD intestine. Inflamm Bowel Dis 2001;7:16-26
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 16-26
    • Lawrance, I.C.1    Maxwell, L.2    Doe, W.3
  • 3
    • 0242266600 scopus 로고    scopus 로고
    • Patterns of disease and surgical treatment among United States veterans more than 50 years of age with ulcerative colitis
    • Longo WE, Virgo KS, Bahadursingh AN, Johnson FE. Patterns of disease and surgical treatment among United States veterans more than 50 years of age with ulcerative colitis. Am J Surg 2003;186:514-18
    • (2003) Am J Surg , vol.186 , pp. 514-518
    • Longo, W.E.1    Virgo, K.S.2    Bahadursingh, A.N.3    Johnson, F.E.4
  • 6
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med 2002;347(6): 417-29
    • (2002) N Engl J Med , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 8
    • 84864832613 scopus 로고    scopus 로고
    • Crucial steps in the natural history of inflammatory bowel disease
    • Latella G, Papi C. Crucial steps in the natural history of inflammatory bowel disease. World J Gastroenterol 2012;18:3790-9
    • (2012) World J Gastroenterol , vol.18 , pp. 3790-3799
    • Latella, G.1    Papi, C.2
  • 9
    • 12344291265 scopus 로고    scopus 로고
    • Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
    • Cosnes J, Nion-Larmurier I, Beaugerie L, Afchain P, Tiret E, Gendre JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005;54:237-41
    • (2005) Gut , vol.54 , pp. 237-241
    • Cosnes, J.1    Nion-Larmurier, I.2    Beaugerie, L.3    Afchain, P.4    Tiret, E.5    Gendre, J.P.6
  • 11
    • 84863702343 scopus 로고    scopus 로고
    • Mechanisms of fibrosis: therapeutic translation for fibrotic disease
    • Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 2012;18:1028-40
    • (2012) Nat Med , vol.18 , pp. 1028-1040
    • Wynn, T.A.1    Ramalingam, T.R.2
  • 13
    • 0034882269 scopus 로고    scopus 로고
    • Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease
    • Lawrance IC, Maxwell L, Doe W. Altered response of intestinal mucosal fibroblasts to profibrogenic cytokines in inflammatory bowel disease. Inflamm Bowel Dis 2001;7:226-36
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 226-236
    • Lawrance, I.C.1    Maxwell, L.2    Doe, W.3
  • 14
    • 0033696546 scopus 로고    scopus 로고
    • Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models
    • Pucilowska JB, Williams KL, Lund PK. Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models. Am J Physiol Gastrointest Liver Physiol 2000;279:G653-G659
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279 , pp. G653-G659
    • Pucilowska, J.B.1    Williams, K.L.2    Lund, P.K.3
  • 15
    • 67649888821 scopus 로고    scopus 로고
    • Intestinal fibrosis in IBD-a dynamic, multifactorial process
    • Rieder F, Fiocchi C. Intestinal fibrosis in IBD-a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol 2009;6:228-35
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 228-235
    • Rieder, F.1    Fiocchi, C.2
  • 18
    • 0030119839 scopus 로고    scopus 로고
    • Epithelial growth fraction and expression of p53 tumour suppressor gene in oral submucous fibrosis
    • Cox SC, Walker DM. Epithelial growth fraction and expression of p53 tumour suppressor gene in oral submucous fibrosis. Aust Dent J 1996;41:91-6
    • (1996) Aust Dent J , vol.41 , pp. 91-96
    • Cox, S.C.1    Walker, D.M.2
  • 19
    • 84886688737 scopus 로고    scopus 로고
    • Phenotypic transitions of macrophages orchestrate tissue repair
    • Novak ML, Koh TJ. Phenotypic transitions of macrophages orchestrate tissue repair. Am J Pathol 2013;183:1352-63
    • (2013) Am J Pathol , vol.183 , pp. 1352-1363
    • Novak, M.L.1    Koh, T.J.2
  • 20
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature 2013;496:445-55
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 21
    • 33847676783 scopus 로고    scopus 로고
    • Fibroblasts and myofibroblasts: their source, function and role in disease
    • McAnulty RJ. Fibroblasts and myofibroblasts: their source, function and role in disease. Int J Biochem Cell Biol 2007;39:666-71
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 666-671
    • McAnulty, R.J.1
  • 22
    • 0035877019 scopus 로고    scopus 로고
    • Peripheral blood fibrocytes: differentiation pathway and migration to wound sites
    • Abe R, Donnelly SC, Peng T, Bucala R, Metz CN. Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol 2001;166:7556-62
    • (2001) J Immunol , vol.166 , pp. 7556-7562
    • Abe, R.1    Donnelly, S.C.2    Peng, T.3    Bucala, R.4    Metz, C.N.5
  • 24
    • 0036073299 scopus 로고    scopus 로고
    • Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
    • McKaig BC, Hughes K, Tighe PJ, Mahida YR. Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts. Am J Physiol Cell Physiol 2002;282:C172-C182
    • (2002) Am J Physiol Cell Physiol , vol.282 , pp. C172-C182
    • McKaig, B.C.1    Hughes, K.2    Tighe, P.J.3    Mahida, Y.R.4
  • 27
    • 34547092167 scopus 로고    scopus 로고
    • Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa
    • Brenmoehl J, Lang M, Hausmann M, Leeb SN, Falk W, Scholmerich J, et al. Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa. Int J Colorectal Dis 2007;22:611-23
    • (2007) Int J Colorectal Dis , vol.22 , pp. 611-623
    • Brenmoehl, J.1    Lang, M.2    Hausmann, M.3    Leeb, S.N.4    Falk, W.5    Scholmerich, J.6
  • 29
    • 0033670028 scopus 로고    scopus 로고
    • Prolactin regulation of apoptosis-associated gene expression in T cells
    • Buckley AR, Buckley DJ. Prolactin regulation of apoptosis-associated gene expression in T cells. Ann N Y Acad Sci 2000;917:522-33
    • (2000) Ann N Y Acad Sci , vol.917 , pp. 522-533
    • Buckley, A.R.1    Buckley, D.J.2
  • 30
    • 65549160523 scopus 로고    scopus 로고
    • Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis
    • Hinz B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fibrosis. Curr Rheumatol Rep 2009;11:120-6
    • (2009) Curr Rheumatol Rep , vol.11 , pp. 120-126
    • Hinz, B.1
  • 31
    • 67649690530 scopus 로고    scopus 로고
    • Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease
    • Lang M, Schlechtweg M, Kellermeier S, Brenmoehl J, Falk W, Scholmerich J, et al. Gene expression profiles of mucosal fibroblasts from strictured and nonstrictured areas of patients with Crohn's disease. Inflamm Bowel Dis 2009;15:212-23
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 212-223
    • Lang, M.1    Schlechtweg, M.2    Kellermeier, S.3    Brenmoehl, J.4    Falk, W.5    Scholmerich, J.6
  • 32
    • 79952134815 scopus 로고    scopus 로고
    • beta-catenin mediates mechanically regulated, transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells
    • Chen JH, Chen WL, Sider KL, Yip CY, Simmons CA. beta-catenin mediates mechanically regulated, transforming growth factor-beta1-induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol 2011;31:590-7
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 590-597
    • Chen, J.H.1    Chen, W.L.2    Sider, K.L.3    Yip, C.Y.4    Simmons, C.A.5
  • 33
    • 79955967161 scopus 로고    scopus 로고
    • Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity
    • Heise RL, Stober V, Cheluvaraju C, Hollingsworth JW, Garantziotis S. Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem 2011;286:17435-44
    • (2011) J Biol Chem , vol.286 , pp. 17435-17444
    • Heise, R.L.1    Stober, V.2    Cheluvaraju, C.3    Hollingsworth, J.W.4    Garantziotis, S.5
  • 34
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008;214:199-210
    • (2008) J Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 35
    • 79955562519 scopus 로고    scopus 로고
    • Mesenchymal cell proliferation and programmed cell death: key players in fibrogenesis and new targets for therapeutic intervention
    • Luna J, Masamunt MC, Lawrance IC, Sans M. Mesenchymal cell proliferation and programmed cell death: key players in fibrogenesis and new targets for therapeutic intervention. Am J Physiol Gastrointest Liver Physiol 2011;300:G703-G708
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G703-G708
    • Luna, J.1    Masamunt, M.C.2    Lawrance, I.C.3    Sans, M.4
  • 36
    • 0036083712 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal
    • Sanders KM, Ordog T, Ward SM. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 2002;282:G747-G756
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282 , pp. G747-G756
    • Sanders, K.M.1    Ordog, T.2    Ward, S.M.3
  • 38
    • 0022005425 scopus 로고
    • Cytoskeletal features of rat aortic cells during development. An electron microscopic, immunohistochemical, and biochemical study
    • Kocher O, Skalli O, Cerutti D, Gabbiani F, Gabbiani G. Cytoskeletal features of rat aortic cells during development. An electron microscopic, immunohistochemical, and biochemical study. Circ Res 1985;56:829-38
    • (1985) Circ Res , vol.56 , pp. 829-838
    • Kocher, O.1    Skalli, O.2    Cerutti, D.3    Gabbiani, F.4    Gabbiani, G.5
  • 41
    • 0032742051 scopus 로고    scopus 로고
    • Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential
    • Knittel T, Kobold D, Saile B, Grundmann A, Neubauer K, Piscaglia F, et al. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999;117:1205-21
    • (1999) Gastroenterology , vol.117 , pp. 1205-1221
    • Knittel, T.1    Kobold, D.2    Saile, B.3    Grundmann, A.4    Neubauer, K.5    Piscaglia, F.6
  • 42
    • 0032954505 scopus 로고    scopus 로고
    • Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis
    • Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999;44:534-41
    • (1999) Gut , vol.44 , pp. 534-541
    • Apte, M.V.1    Haber, P.S.2    Darby, S.J.3    Rodgers, S.C.4    McCaughan, G.W.5    Korsten, M.A.6
  • 44
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 2003;314:15-23
    • (2003) Cell Tissue Res , vol.314 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 45
  • 46
    • 0030048787 scopus 로고    scopus 로고
    • Pericytes as collagen-producing cells in excessive dermal scarring
    • Sundberg C, Ivarsson M, Gerdin B, Rubin K. Pericytes as collagen-producing cells in excessive dermal scarring. Lab Invest 1996;74:452-66
    • (1996) Lab Invest , vol.74 , pp. 452-466
    • Sundberg, C.1    Ivarsson, M.2    Gerdin, B.3    Rubin, K.4
  • 47
    • 20444473689 scopus 로고    scopus 로고
    • A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts
    • Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, et al. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts. Gastroenterology 2005;128:1984-95
    • (2005) Gastroenterology , vol.128 , pp. 1984-1995
    • Brittan, M.1    Chance, V.2    Elia, G.3    Poulsom, R.4    Alison, M.R.5    MacDonald, T.T.6
  • 48
    • 77953769774 scopus 로고    scopus 로고
    • Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
    • Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M, Kalluri R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010;285:20202-12
    • (2010) J Biol Chem , vol.285 , pp. 20202-20212
    • Flier, S.N.1    Tanjore, H.2    Kokkotou, E.G.3    Sugimoto, H.4    Zeisberg, M.5    Kalluri, R.6
  • 49
    • 80054976356 scopus 로고    scopus 로고
    • Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis
    • Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, et al. Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis. Am J Pathol 2011;179:2660-73
    • (2011) Am J Pathol , vol.179 , pp. 2660-2673
    • Rieder, F.1    Kessler, S.P.2    West, G.A.3    Bhilocha, S.4    de la Motte, C.5    Sadler, T.M.6
  • 50
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: new insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006;172:973-81
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 52
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003;9:964-8
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1    Hanai, J.2    Sugimoto, H.3    Mammoto, T.4    Charytan, D.5    Strutz, F.6
  • 53
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem 2007;282:23337-47
    • (2007) J Biol Chem , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6
  • 54
    • 18444374439 scopus 로고    scopus 로고
    • In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions
    • Ishii G, Sangai T, Sugiyama K, Ito T, Hasebe T, Endoh Y, et al. In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions. Stem Cells 2005;23:699-706
    • (2005) Stem Cells , vol.23 , pp. 699-706
    • Ishii, G.1    Sangai, T.2    Sugiyama, K.3    Ito, T.4    Hasebe, T.5    Endoh, Y.6
  • 55
    • 77958187285 scopus 로고    scopus 로고
    • Intestinal stem cells
    • Umar S. Intestinal stem cells. Curr Gastroenterol Rep 2010;12:340-8
    • (2010) Curr Gastroenterol Rep , vol.12 , pp. 340-348
    • Umar, S.1
  • 56
  • 57
    • 34547960749 scopus 로고    scopus 로고
    • The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses
    • Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007;87:858-70
    • (2007) Lab Invest , vol.87 , pp. 858-870
    • Bellini, A.1    Mattoli, S.2
  • 58
    • 0347361659 scopus 로고    scopus 로고
    • Human circulating CD14 + monocytes as a source of progenitors that exhibit mesenchymal cell differentiation
    • Kuwana M, Okazaki Y, Kodama H, Izumi K, Yasuoka H, Ogawa Y, et al. Human circulating CD14 + monocytes as a source of progenitors that exhibit mesenchymal cell differentiation. J Leukoc Biol 2003;74:833-45
    • (2003) J Leukoc Biol , vol.74 , pp. 833-845
    • Kuwana, M.1    Okazaki, Y.2    Kodama, H.3    Izumi, K.4    Yasuoka, H.5    Ogawa, Y.6
  • 62
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • Tsang CK, Qi H, Liu LF, Zheng XF. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007;12:112-24
    • (2007) Drug Discov Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.4
  • 64
    • 0029913624 scopus 로고    scopus 로고
    • Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
    • Babyatsky MW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996;110:975-84
    • (1996) Gastroenterology , vol.110 , pp. 975-984
    • Babyatsky, M.W.1    Rossiter, G.2    Podolsky, D.K.3
  • 65
    • 34247586091 scopus 로고    scopus 로고
    • Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2, 4, 6-trinitrobenzene sulfonic acid colitis
    • Fichtner-Feigl S, Fuss IJ, Young CA, Watanabe T, Geissler EK, Schlitt HJ, et al. Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2, 4, 6-trinitrobenzene sulfonic acid colitis. J Immunol 2007;178:5859-70
    • (2007) J Immunol , vol.178 , pp. 5859-5870
    • Fichtner-Feigl, S.1    Fuss, I.J.2    Young, C.A.3    Watanabe, T.4    Geissler, E.K.5    Schlitt, H.J.6
  • 66
    • 57249094020 scopus 로고    scopus 로고
    • IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis
    • [2013 e1-7]
    • Fichtner-Feigl S, Young CA, Kitani A, Geissler EK, Schlitt HJ, Strober W. IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 2008;135:2003-2013 [2013 e1-7]
    • (2008) Gastroenterology , vol.135 , pp. 2003-2013
    • Fichtner-Feigl, S.1    Young, C.A.2    Kitani, A.3    Geissler, E.K.4    Schlitt, H.J.5    Strober, W.6
  • 67
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-84
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 68
    • 84867145469 scopus 로고    scopus 로고
    • Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease
    • Rieder F, Kessler S, Sans M, Fiocchi C. Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease. Am J Physiol Gastrointest Liver Physiol 2012;303:G786-G801
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.303 , pp. G786-G801
    • Rieder, F.1    Kessler, S.2    Sans, M.3    Fiocchi, C.4
  • 71
    • 58649088728 scopus 로고    scopus 로고
    • Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis
    • Latella G, Vetuschi A, Sferra R, Zanninelli G, D'Angelo A, Catitti V, et al. Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis. Eur J Clin Invest 2009;39:145-56
    • (2009) Eur J Clin Invest , vol.39 , pp. 145-156
    • Latella, G.1    Vetuschi, A.2    Sferra, R.3    Zanninelli, G.4    D'Angelo, A.5    Catitti, V.6
  • 74
    • 2542609844 scopus 로고    scopus 로고
    • Smad3 as a mediator of the fibrotic response
    • Flanders KC. Smad3 as a mediator of the fibrotic response. Int J Exp Pathol 2004;85:47-64
    • (2004) Int J Exp Pathol , vol.85 , pp. 47-64
    • Flanders, K.C.1
  • 75
    • 2942535966 scopus 로고    scopus 로고
    • Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
    • Fukasawa H, Yamamoto T, Togawa A, Ohashi N, Fujigaki Y, Oda T, et al. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci U S A 2004;101:8687-92
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8687-8692
    • Fukasawa, H.1    Yamamoto, T.2    Togawa, A.3    Ohashi, N.4    Fujigaki, Y.5    Oda, T.6
  • 76
    • 3242797424 scopus 로고    scopus 로고
    • Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
    • Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, et al. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 2004;66:597-604
    • (2004) Kidney Int , vol.66 , pp. 597-604
    • Inazaki, K.1    Kanamaru, Y.2    Kojima, Y.3    Sueyoshi, N.4    Okumura, K.5    Kaneko, K.6
  • 77
    • 3042550759 scopus 로고    scopus 로고
    • Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    • Lakos G, Takagawa S, Chen SJ, Ferreira AM, Han G, Masuda K, et al. Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 2004;165:203-17
    • (2004) Am J Pathol , vol.165 , pp. 203-217
    • Lakos, G.1    Takagawa, S.2    Chen, S.J.3    Ferreira, A.M.4    Han, G.5    Masuda, K.6
  • 78
    • 44049097231 scopus 로고    scopus 로고
    • Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2, 4, 5-trinitrobenzene sulphonic acid
    • Latella G, Sferra R, Vetuschi A, Zanninelli G, D'Angelo A, Catitti V, et al. Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2, 4, 5-trinitrobenzene sulphonic acid. Eur J Clin Invest 2008;38:410-20
    • (2008) Eur J Clin Invest , vol.38 , pp. 410-420
    • Latella, G.1    Sferra, R.2    Vetuschi, A.3    Zanninelli, G.4    D'Angelo, A.5    Catitti, V.6
  • 79
    • 0032719815 scopus 로고    scopus 로고
    • Transient gene transfer and expression of Smad7 prevents bleomycininduced lung fibrosis in mice
    • Nakao A, Fujii M, Matsumura R, Kumano K, Saito Y, Miyazono K, et al. Transient gene transfer and expression of Smad7 prevents bleomycininduced lung fibrosis in mice. J Clin Invest 1999;104:5-11
    • (1999) J Clin Invest , vol.104 , pp. 5-11
    • Nakao, A.1    Fujii, M.2    Matsumura, R.3    Kumano, K.4    Saito, Y.5    Miyazono, K.6
  • 80
    • 0036086293 scopus 로고    scopus 로고
    • Jr., Datto MB, et al. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
    • Zhao J, Shi W, Wang YL, Chen H, Bringas P. Jr., Datto MB, et al. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2002;282:L585-L593
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282 , pp. L585-L593
    • Zhao, J.1    Shi, W.2    Wang, Y.L.3    Chen, H.4    Bringas, P.5
  • 81
    • 66649106333 scopus 로고    scopus 로고
    • Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
    • Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NA, et al. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 2009;58:777-89
    • (2009) Gut , vol.58 , pp. 777-789
    • Di Sabatino, A.1    Jackson, C.L.2    Pickard, K.M.3    Buckley, M.4    Rovedatti, L.5    Leakey, N.A.6
  • 83
    • 0242457599 scopus 로고    scopus 로고
    • Effect of collagen matrices on dermal wound healing
    • Ruszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev 2003;55:1595-611
    • (2003) Adv Drug Deliv Rev , vol.55 , pp. 1595-1611
    • Ruszczak, Z.1
  • 84
    • 33747626518 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in intestinal inflammation
    • Medina C, Radomski MW. Role of matrix metalloproteinases in intestinal inflammation. J Pharmacol Exp Ther 2006;318:933-8
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 933-938
    • Medina, C.1    Radomski, M.W.2
  • 85
    • 0028986030 scopus 로고
    • Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring
    • Shah M, Foreman DM, Ferguson MW. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995;108:985-1002
    • (1995) J Cell Sci , vol.108 , pp. 985-1002
    • Shah, M.1    Foreman, D.M.2    Ferguson, M.W.3
  • 86
    • 13944284151 scopus 로고    scopus 로고
    • TGF-beta1, TGF-beta3, and PGE(2) regulate contraction of human patellar tendon fibroblasts
    • Campbell BH, Agarwal C, Wang JH. TGF-beta1, TGF-beta3, and PGE(2) regulate contraction of human patellar tendon fibroblasts. Biomech Model Mechanobiol 2004;2:239-45
    • (2004) Biomech Model Mechanobiol , vol.2 , pp. 239-245
    • Campbell, B.H.1    Agarwal, C.2    Wang, J.H.3
  • 87
    • 0028986030 scopus 로고
    • Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring
    • Shah M, Foreman DM, Ferguson MW. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995;108(Pt 3):985-1002
    • (1995) J Cell Sci , vol.108 , pp. 985-1002
    • Shah, M.1    Foreman, D.M.2    Ferguson, M.W.3
  • 89
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni AB, Huh CG, Becker D, Geiser A, Lyght M, Flanders KC, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 1993;90:770-4
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3    Geiser, A.4    Lyght, M.5    Flanders, K.C.6
  • 90
    • 0032565859 scopus 로고    scopus 로고
    • Smad2 role in mesoderm formation, left-right patterning and craniofacial development
    • Nomura M, Li E. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 1998;393:786-90
    • (1998) Nature , vol.393 , pp. 786-790
    • Nomura, M.1    Li, E.2
  • 91
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • Yang X, Li C, Xu X, Deng C. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A 1998;95:3667-72
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 92
    • 0032934979 scopus 로고    scopus 로고
    • Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
    • Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999;19:2495-504
    • (1999) Mol Cell Biol , vol.19 , pp. 2495-2504
    • Datto, M.B.1    Frederick, J.P.2    Pan, L.3    Borton, A.J.4    Zhuang, Y.5    Wang, X.F.6
  • 93
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    • Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, et al. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J 1999;18:1280-91
    • (1999) EMBO J , vol.18 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6
  • 94
    • 0032544448 scopus 로고    scopus 로고
    • Smad3 mutant mice develop metastatic colorectal cancer
    • Zhu Y, Richardson JA, Parada LF, Graff JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998;94:703-14
    • (1998) Cell , vol.94 , pp. 703-714
    • Zhu, Y.1    Richardson, J.A.2    Parada, L.F.3    Graff, J.M.4
  • 95
    • 84864796944 scopus 로고    scopus 로고
    • Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis
    • Baghy K, Iozzo RV, Kovalszky I. Decorin-TGFbeta axis in hepatic fibrosis and cirrhosis. J Histochem Cytochem 2012;60:262-8
    • (2012) J Histochem Cytochem , vol.60 , pp. 262-268
    • Baghy, K.1    Iozzo, R.V.2    Kovalszky, I.3
  • 96
    • 33746151631 scopus 로고    scopus 로고
    • Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?
    • Liu Y, Yang J. Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?. Kidney Int 2006;70:238-40
    • (2006) Kidney Int , vol.70 , pp. 238-240
    • Liu, Y.1    Yang, J.2
  • 97
    • 78651099581 scopus 로고    scopus 로고
    • Hepatocyte growth factor in lung repair and pulmonary fibrosis
    • Panganiban RA, Day RM. Hepatocyte growth factor in lung repair and pulmonary fibrosis. Acta Pharmacol Sin 2011;32:12-20
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 12-20
    • Panganiban, R.A.1    Day, R.M.2
  • 98
    • 84880529428 scopus 로고    scopus 로고
    • BMP-7 counteracting TGF-beta1 activities in organ fibrosis
    • Weiskirchen R, Meurer SK. BMP-7 counteracting TGF-beta1 activities in organ fibrosis. Front Biosci (Landmark Ed) 2013;18:1407-34
    • (2013) Front Biosci (Landmark Ed) , vol.18 , pp. 1407-1434
    • Weiskirchen, R.1    Meurer, S.K.2
  • 100
    • 33744515391 scopus 로고    scopus 로고
    • Roles of activin in tissue repair, fibrosis, and inflammatory disease
    • Werner S, Alzheimer C. Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokine Growth Factor Rev 2006;17:157-71
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 157-171
    • Werner, S.1    Alzheimer, C.2
  • 102
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: a mediator of TGFbeta action on fibroblasts
    • Grotendorst GR. Connective tissue growth factor: a mediator of TGFbeta action on fibroblasts. Cytokine Growth Factor Rev 1997;8:171-9
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 171-179
    • Grotendorst, G.R.1
  • 103
    • 0036775477 scopus 로고    scopus 로고
    • Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?
    • Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?. Matrix Biol 2002;21:473-82
    • (2002) Matrix Biol , vol.21 , pp. 473-482
    • Blom, I.E.1    Goldschmeding, R.2    Leask, A.3
  • 104
    • 84860349542 scopus 로고    scopus 로고
    • Regulation of hepatic stellate cells by connective tissue growth factor
    • Huang G, Brigstock DR. Regulation of hepatic stellate cells by connective tissue growth factor. Front Biosci (Landmark Ed) 2012;17:2495-507
    • (2012) Front Biosci (Landmark Ed) , vol.17 , pp. 2495-2507
    • Huang, G.1    Brigstock, D.R.2
  • 105
    • 70849136597 scopus 로고    scopus 로고
    • Connective tissue growth factor-(CTGF, CCN2)-a marker, mediator and therapeutic target for renal fibrosis
    • Phanish MK, Winn SK, Dockrell ME. Connective tissue growth factor-(CTGF, CCN2)-a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 2010;114:e83-e92
    • (2010) Nephron Exp Nephrol , vol.114 , pp. e83-e92
    • Phanish, M.K.1    Winn, S.K.2    Dockrell, M.E.3
  • 106
    • 0035677983 scopus 로고    scopus 로고
    • Shimosegawa, et al. Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease
    • Kumagai S, Ohtani H, Nagai T, Funa K, Hiwatashi NO. Shimosegawa, et al. Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease. Tohoku J Exp Med 2001;195:21-33
    • (2001) Tohoku J Exp Med , vol.195 , pp. 21-33
    • Kumagai, S.1    Ohtani, H.2    Nagai, T.3    Funa, K.4    Hiwatashi, N.O.5
  • 107
    • 2942682928 scopus 로고    scopus 로고
    • Regulation of PDGF and its receptors in fibrotic diseases
    • Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 2004;15:255-73
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 255-273
    • Bonner, J.C.1
  • 109
    • 65849497785 scopus 로고    scopus 로고
    • Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis
    • Distler JH, Distler O. Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis. Rheumatology (Oxford) 2008;47(Suppl. 5):v10-v11
    • (2008) Rheumatology (Oxford) , vol.47 , pp. v10-v11
    • Distler, J.H.1    Distler, O.2
  • 110
    • 0036721057 scopus 로고    scopus 로고
    • IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts
    • Simmons J, Pucliowska J, Keku T, Lund P. IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts. Am J Physiol Gastrointest Liver Physiol 2002;283:G809-G818
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.283 , pp. G809-G818
    • Simmons, J.1    Pucliowska, J.2    Keku, T.3    Lund, P.4
  • 112
    • 0027216271 scopus 로고
    • Insulin-like growth factor 1 and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis
    • Zimmermann EM, Sartor RB, McCall RD, Pardo M, Bender D, Lund PK. Insulin-like growth factor 1 and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis. Gastroenterology 1993;105:399-409
    • (1993) Gastroenterology , vol.105 , pp. 399-409
    • Zimmermann, E.M.1    Sartor, R.B.2    McCall, R.D.3    Pardo, M.4    Bender, D.5    Lund, P.K.6
  • 113
    • 79251501315 scopus 로고    scopus 로고
    • Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease
    • Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem 2011;149:121-30
    • (2011) J Biochem , vol.149 , pp. 121-130
    • Itoh, N.1    Ornitz, D.M.2
  • 114
    • 4644318578 scopus 로고    scopus 로고
    • Serum bFGF and VEGF correlate respectively with bowel wall thickness and intramural blood flow in Crohn's disease
    • Di Sabatino A, Ciccocioppo R, Armellini E, Morera R, Ricevuti L, Cazzola P, et al. Serum bFGF and VEGF correlate respectively with bowel wall thickness and intramural blood flow in Crohn's disease. Inflamm Bowel Dis 2004;10:573-7
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 573-577
    • Di Sabatino, A.1    Ciccocioppo, R.2    Armellini, E.3    Morera, R.4    Ricevuti, L.5    Cazzola, P.6
  • 115
    • 51349168153 scopus 로고    scopus 로고
    • Effects of basic fibroblast growth factors on hypertrophic scarring in a rabbit ear model
    • Xie J, Qi S, Xu Y, Tang J, Li T, Liu X, et al. Effects of basic fibroblast growth factors on hypertrophic scarring in a rabbit ear model. J Cutan Med Surg 2008;12:155-62
    • (2008) J Cutan Med Surg , vol.12 , pp. 155-162
    • Xie, J.1    Qi, S.2    Xu, Y.3    Tang, J.4    Li, T.5    Liu, X.6
  • 116
    • 84884536419 scopus 로고    scopus 로고
    • Pathophysiological roles of FGF signaling in the heart
    • Itoh N, Ohta H. Pathophysiological roles of FGF signaling in the heart. Front Physiol 2013;4:247
    • (2013) Front Physiol , vol.4 , pp. 247
    • Itoh, N.1    Ohta, H.2
  • 118
    • 0042308353 scopus 로고    scopus 로고
    • The EGF receptor family-multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4
    • [discussion 333-4]
    • Earp HS III, Calvo BF, Sartor CI. The EGF receptor family-multiple roles in proliferation, differentiation, and neoplasia with an emphasis on HER4. Trans Am Clin Climatol Assoc 2003;114:315-33 [discussion 333-4]
    • (2003) Trans Am Clin Climatol Assoc , vol.114 , pp. 315-333
    • Earp, H.S.1    Calvo, B.F.2    Sartor, C.I.3
  • 119
    • 26444515531 scopus 로고    scopus 로고
    • Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts
    • Hetzel M, Bachem M, Anders D, Trischler G, Faehling M. Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts. Lung 2005;183:225-37
    • (2005) Lung , vol.183 , pp. 225-237
    • Hetzel, M.1    Bachem, M.2    Anders, D.3    Trischler, G.4    Faehling, M.5
  • 120
    • 0033636796 scopus 로고    scopus 로고
    • Increased expression of epidermal growth factor-receptor in an experimental model of colitis in rats
    • Hoffmann P, Reinshagen M, Zeeh JM, Lakshmanan J, Wu VS, Goebell H, et al. Increased expression of epidermal growth factor-receptor in an experimental model of colitis in rats. Scand J Gastroenterol 2000;35:1174-80
    • (2000) Scand J Gastroenterol , vol.35 , pp. 1174-1180
    • Hoffmann, P.1    Reinshagen, M.2    Zeeh, J.M.3    Lakshmanan, J.4    Wu, V.S.5    Goebell, H.6
  • 121
    • 65549121606 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration
    • Brenmoehl J, Miller SN, Hofmann C, Vogl D, Falk W, Scholmerich J, et al. Transforming growth factor-beta 1 induces intestinal myofibroblast differentiation and modulates their migration. World J Gastroenterol 2009;15:1431-42
    • (2009) World J Gastroenterol , vol.15 , pp. 1431-1442
    • Brenmoehl, J.1    Miller, S.N.2    Hofmann, C.3    Vogl, D.4    Falk, W.5    Scholmerich, J.6
  • 122
    • 79956313171 scopus 로고    scopus 로고
    • Migration of connective tissue-derived cells is mediated by ultra-low concentration gradient fields of EGF
    • Kong Q, Majeska RJ, Vazquez M. Migration of connective tissue-derived cells is mediated by ultra-low concentration gradient fields of EGF. Exp Cell Res 2011;317:1491-502
    • (2011) Exp Cell Res , vol.317 , pp. 1491-1502
    • Kong, Q.1    Majeska, R.J.2    Vazquez, M.3
  • 123
    • 67049172488 scopus 로고    scopus 로고
    • Interleukin-1 participates in the progression from liver injury to fibrosis
    • Gieling RG, Wallace K, Han YP. Interleukin-1 participates in the progression from liver injury to fibrosis. Am J Physiol Gastrointest Liver Physiol 2009;296:G1324-G1331
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. G1324-G1331
    • Gieling, R.G.1    Wallace, K.2    Han, Y.P.3
  • 124
    • 57349194661 scopus 로고    scopus 로고
    • Inflammatory cytokines augments TGF-beta1-induced epithelialmesenchymal transition in A549 cells by up-regulating TbetaR-I
    • Liu X. Inflammatory cytokines augments TGF-beta1-induced epithelialmesenchymal transition in A549 cells by up-regulating TbetaR-I. Cell Motil Cytoskeleton 2008;65:935-44
    • (2008) Cell Motil Cytoskeleton , vol.65 , pp. 935-944
    • Liu, X.1
  • 126
    • 67650935391 scopus 로고    scopus 로고
    • Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection
    • Diaz JA, Booth AJ, Lu G, Wood SC, Pinsky DJ, Bishop DK. Critical role for IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant 2009;9:1773-83
    • (2009) Am J Transplant , vol.9 , pp. 1773-1783
    • Diaz, J.A.1    Booth, A.J.2    Lu, G.3    Wood, S.C.4    Pinsky, D.J.5    Bishop, D.K.6
  • 127
    • 73349121322 scopus 로고    scopus 로고
    • Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice
    • Luckett-Chastain LR, Gallucci RM. Interleukin (IL)-6 modulates transforming growth factor-beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol 2009;161:237-48
    • (2009) Br J Dermatol , vol.161 , pp. 237-248
    • Luckett-Chastain, L.R.1    Gallucci, R.M.2
  • 129
    • 0036219823 scopus 로고    scopus 로고
    • IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis
    • Huang M, Sharma S, Zhu LX, Keane MP, Luo J, Zhang L, et al. IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis. J Clin Invest 2002;109:931-7
    • (2002) J Clin Invest , vol.109 , pp. 931-937
    • Huang, M.1    Sharma, S.2    Zhu, L.X.3    Keane, M.P.4    Luo, J.5    Zhang, L.6
  • 130
    • 3142544273 scopus 로고    scopus 로고
    • Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis
    • Zhang L, Keane MP, Zhu LX, Sharma S, Rozengurt E, Strieter RM, et al. Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. J Biol Chem 2004;279:28315-9
    • (2004) J Biol Chem , vol.279 , pp. 28315-28319
    • Zhang, L.1    Keane, M.P.2    Zhu, L.X.3    Sharma, S.4    Rozengurt, E.5    Strieter, R.M.6
  • 132
    • 0034923170 scopus 로고    scopus 로고
    • Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis
    • Chiaramonte MG, Cheever AW, Malley JD, Donaldson DD, Wynn TA. Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis. Hepatology 2001;34:273-82
    • (2001) Hepatology , vol.34 , pp. 273-282
    • Chiaramonte, M.G.1    Cheever, A.W.2    Malley, J.D.3    Donaldson, D.D.4    Wynn, T.A.5
  • 133
    • 0035987319 scopus 로고    scopus 로고
    • Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma
    • Kumar RK, Herbert C, Yang M, Koskinen AM, McKenzie AN, Foster PS. Role of interleukin-13 in eosinophil accumulation and airway remodelling in a mouse model of chronic asthma. Clin Exp Allergy 2002;32:1104-11
    • (2002) Clin Exp Allergy , vol.32 , pp. 1104-1111
    • Kumar, R.K.1    Herbert, C.2    Yang, M.3    Koskinen, A.M.4    McKenzie, A.N.5    Foster, P.S.6
  • 134
    • 79955565441 scopus 로고    scopus 로고
    • Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
    • Barron L, Wynn TA. Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am J Physiol Gastrointest Liver Physiol 2011;300:G723-G728
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.300 , pp. G723-G728
    • Barron, L.1    Wynn, T.A.2
  • 135
    • 1642566536 scopus 로고    scopus 로고
    • The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling
    • Ma B, Zhu Z, Homer RJ, Gerard C, Strieter R, Elias JA. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 2004;172:1872-81
    • (2004) J Immunol , vol.172 , pp. 1872-1881
    • Ma, B.1    Zhu, Z.2    Homer, R.J.3    Gerard, C.4    Strieter, R.5    Elias, J.A.6
  • 139
    • 79960736362 scopus 로고    scopus 로고
    • Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis
    • Guan Q, Ma Y, Hillman CL, Qing G, Ma AG, Weiss CR, et al. Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis. Mol Med 2011;17:646-56
    • (2011) Mol Med , vol.17 , pp. 646-656
    • Guan, Q.1    Ma, Y.2    Hillman, C.L.3    Qing, G.4    Ma, A.G.5    Weiss, C.R.6
  • 140
    • 43549099743 scopus 로고    scopus 로고
    • The Interleukin-23/Interleukin-17 axis in intestinal inflammation
    • Maloy KJ. The Interleukin-23/Interleukin-17 axis in intestinal inflammation. J Intern Med 2008;263:584-90
    • (2008) J Intern Med , vol.263 , pp. 584-590
    • Maloy, K.J.1
  • 141
    • 0036088374 scopus 로고    scopus 로고
    • IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts
    • Hata K, Andoh A, Shimada M, Fujino S, Bamba S, Araki Y, et al. IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol 2002;282:G1035-G1044
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282 , pp. G1035-G1044
    • Hata, K.1    Andoh, A.2    Shimada, M.3    Fujino, S.4    Bamba, S.5    Araki, Y.6
  • 142
    • 80053070208 scopus 로고    scopus 로고
    • Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and-independent mechanisms
    • Mi S, Li Z, Yang HZ, Liu H, Wang JP, Ma YG, et al. Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and-independent mechanisms. J Immunol 2011;187:3003-14
    • (2011) J Immunol , vol.187 , pp. 3003-3014
    • Mi, S.1    Li, Z.2    Yang, H.Z.3    Liu, H.4    Wang, J.P.5    Ma, Y.G.6
  • 144
    • 77953021137 scopus 로고    scopus 로고
    • Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy
    • Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, et al. Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res 2010;106:1646-55
    • (2010) Circ Res , vol.106 , pp. 1646-1655
    • Baldeviano, G.C.1    Barin, J.G.2    Talor, M.V.3    Srinivasan, S.4    Bedja, D.5    Zheng, D.6
  • 145
    • 78650199530 scopus 로고    scopus 로고
    • Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts
    • Sponheim J, Pollheimer J, Olsen T, Balogh J, Hammarstrom C, Loos T, et al. Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol 2010;177:2804-15
    • (2010) Am J Pathol , vol.177 , pp. 2804-2815
    • Sponheim, J.1    Pollheimer, J.2    Olsen, T.3    Balogh, J.4    Hammarstrom, C.5    Loos, T.6
  • 147
    • 27744461703 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2
    • Theiss AL, Simmons JG, Jobin C, Lund PK. Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2. J Biol Chem 2005;280:36099-109
    • (2005) J Biol Chem , vol.280 , pp. 36099-36109
    • Theiss, A.L.1    Simmons, J.G.2    Jobin, C.3    Lund, P.K.4
  • 148
    • 79551529001 scopus 로고    scopus 로고
    • The TNFfamily cytokine TL1A drives IL-13-dependent small intestinal inflammation
    • Meylan F, Song YJ, Fuss I, Villarreal S, Kahle E, Malm IJ, et al. The TNFfamily cytokine TL1A drives IL-13-dependent small intestinal inflammation. Mucosal Immunol 2011;4:172-85
    • (2011) Mucosal Immunol , vol.4 , pp. 172-185
    • Meylan, F.1    Song, Y.J.2    Fuss, I.3    Villarreal, S.4    Kahle, E.5    Malm, I.J.6
  • 149
    • 79251581032 scopus 로고    scopus 로고
    • Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis
    • Shih DQ, Barrett R, Zhang X, Yeager N, Koon HW, Phaosawasdi P, et al. Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis. PLoS One 2011;6:e16090
    • (2011) PLoS One , vol.6
    • Shih, D.Q.1    Barrett, R.2    Zhang, X.3    Yeager, N.4    Koon, H.W.5    Phaosawasdi, P.6
  • 150
    • 84862927426 scopus 로고    scopus 로고
    • Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis
    • Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, et al. Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis. Am J Pathol 2012;180:636-49
    • (2012) Am J Pathol , vol.180 , pp. 636-649
    • Barrett, R.1    Zhang, X.2    Koon, H.W.3    Vu, M.4    Chang, J.Y.5    Yeager, N.6
  • 151
    • 61849115157 scopus 로고    scopus 로고
    • IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
    • Michelsen KS, Thomas LS, Taylor KD, Yu QT, Mei L, Landers CJ, et al. IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein. PLoS One 2009;4:e4719
    • (2009) PLoS One , vol.4
    • Michelsen, K.S.1    Thomas, L.S.2    Taylor, K.D.3    Yu, Q.T.4    Mei, L.5    Landers, C.J.6
  • 152
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factorbeta/SMAD signalling by the interferon-gamma/STAT pathway
    • Ulloa L, Doody J, Massague J. Inhibition of transforming growth factorbeta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 1999;397:710-13
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massague, J.3
  • 153
    • 0029124143 scopus 로고
    • Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression
    • Gurujeyalakshmi G, Giri SN. Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression. Exp Lung Res 1995;21:791-808
    • (1995) Exp Lung Res , vol.21 , pp. 791-808
    • Gurujeyalakshmi, G.1    Giri, S.N.2
  • 154
    • 0242490282 scopus 로고    scopus 로고
    • Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase
    • Leeb SN, Vogl D, Gunckel M, Kiessling S, Falk W, Goke M, et al. Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase. Gastroenterology 2003;125:1341-54
    • (2003) Gastroenterology , vol.125 , pp. 1341-1354
    • Leeb, S.N.1    Vogl, D.2    Gunckel, M.3    Kiessling, S.4    Falk, W.5    Goke, M.6
  • 156
    • 67650349068 scopus 로고    scopus 로고
    • Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial
    • King TE Jr, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, et al. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial. Lancet 2009;374:222-8
    • (2009) Lancet , vol.374 , pp. 222-228
    • King, T.E.1    Albera, C.2    Bradford, W.Z.3    Costabel, U.4    Hormel, P.5    Lancaster, L.6
  • 157
    • 54549111991 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress and fibrogenic response
    • [viii]
    • Urtasun R, Conde de la Rosa L, Nieto N. Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis 2008;12:769-90 [viii]
    • (2008) Clin Liver Dis , vol.12 , pp. 769-790
    • Urtasun, R.1    Conde de la Rosa, L.2    Nieto, N.3
  • 159
    • 0035145392 scopus 로고    scopus 로고
    • Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells
    • Svegliati-Baroni G, Saccomanno S, van Goor H, Jansen P, Benedetti A, Moshage H. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 2001;21:1-12
    • (2001) Liver , vol.21 , pp. 1-12
    • Svegliati-Baroni, G.1    Saccomanno, S.2    van Goor, H.3    Jansen, P.4    Benedetti, A.5    Moshage, H.6
  • 160
    • 0029115715 scopus 로고
    • Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity
    • Rachmilewitz D, Karmeli F, Okon E, Bursztyn M. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995;37:247-55
    • (1995) Gut , vol.37 , pp. 247-255
    • Rachmilewitz, D.1    Karmeli, F.2    Okon, E.3    Bursztyn, M.4
  • 161
    • 67649784378 scopus 로고    scopus 로고
    • Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science
    • Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol 2008;24:462-8
    • (2008) Curr Opin Gastroenterol , vol.24 , pp. 462-468
    • Rieder, F.1    Fiocchi, C.2
  • 162
    • 34249944864 scopus 로고    scopus 로고
    • Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow
    • Danese S. Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow. Curr Opin Gastroenterol 2007;23:384-9
    • (2007) Curr Opin Gastroenterol , vol.23 , pp. 384-389
    • Danese, S.1
  • 163
    • 79958227886 scopus 로고    scopus 로고
    • Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'
    • Danese S. Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'. Gut 2011;60:998-1008
    • (2011) Gut , vol.60 , pp. 998-1008
    • Danese, S.1
  • 165


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.