-
1
-
-
77957238924
-
Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy
-
SCHIRBEL A, FIOCCHI C. Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy. J Dig Dis 2010; 11: 266-276.
-
(2010)
J Dig Dis
, vol.11
, pp. 266-276
-
-
Schirbel, A.1
Fiocchi, C.2
-
2
-
-
70949107842
-
Inflammatory bowel disease
-
ABRAHAM C, CHO JH. Inflammatory bowel disease. N Engl J Med 2009; 361: 2066-2078.
-
(2009)
N Engl J Med
, vol.361
, pp. 2066-2078
-
-
Abraham, C.1
Cho, J.H.2
-
4
-
-
84864832613
-
Crucial steps in the natural history of inflammatory bowel disease
-
LATELLA G, PAPI C. Crucial steps in the natural history of inflammatory bowel disease. World J Gastroenterol 2012; 18: 3790-3799.
-
(2012)
World J Gastroenterol
, vol.18
, pp. 3790-3799
-
-
Latella, G.1
Papi, C.2
-
5
-
-
84858079585
-
Results of the 2nd scientific workshop of the ECCO (III): Basic mechanisms of intestinal healing
-
RIEDER F, KARRASCH T, BEN-HORIN S, SCHIRBEL A, EHEHALT R, WEHKAMP J, DE HAAR C, VELIN D, LATELLA G, SCALDAFERRI F, ROGLER G, HIGGINS P, SANS M. Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing. J Crohns Colitis 2012; 6: 373-385.
-
(2012)
J Crohns Colitis
, vol.6
, pp. 373-385
-
-
Rieder, F.1
Karrasch, T.2
Ben-Horin, S.3
Schirbel, A.4
Ehehalt, R.5
Wehkamp, J.6
De Haar, C.7
Velin, D.8
Latella, G.9
Scaldaferri, F.10
Rogler, G.11
Higgins, P.12
Sans, M.13
-
7
-
-
33846488954
-
Fibrogenesis in Crohn's disease
-
BURKE JP, MULSOW JJ, O'KEANE C, DOCHERTY NG, WATSON RW, O'CONNELL PR. Fibrogenesis in Crohn's disease. Am J Gastroenterol 2007; 102: 439-448.
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 439-448
-
-
Burke, J.P.1
Mulsow, J.J.2
O'keane, C.3
Docherty, N.G.4
Watson, R.W.5
O'connell, P.R.6
-
8
-
-
56449084208
-
Intestinal fibrosis in inflammatory bowel disease-Current knowledge and future perspectives
-
RIEDER F, FIOCCHI C. Intestinal fibrosis in inflammatory bowel disease-Current knowledge and future perspectives. J Crohns Colitis 2008; 2: 279-290.
-
(2008)
J Crohns Colitis
, vol.2
, pp. 279-290
-
-
Rieder, F.1
Fiocchi, C.2
-
9
-
-
67649888821
-
Intestinal fibrosis in IBD - A dynamic, multifactorial process
-
RIEDER F, FIOCCHI C. Intestinal fibrosis in IBD-a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol 2009; 6: 228-235.
-
(2009)
Nat Rev Gastroenterol Hepatol
, vol.6
, pp. 228-235
-
-
Rieder, F.1
Fiocchi, C.2
-
10
-
-
84864428677
-
Pro-fibrogenic activity of Toll-like receptor (TLR) and NOD-Like Receptor (NLR) ligands on Human Intestinal Myofibroblasts (HIF)-linking bacterial innate immunity to intestinal fibrosis
-
RIEDER F, SCHIRBEL A, OUYGAN Z, WEST G, RHO H, DE LA MOTTE C, FIOCCHI C. Pro-fibrogenic activity of Toll-like receptor (TLR) and NOD-Like Receptor (NLR) ligands on Human Intestinal Myofibroblasts (HIF)-linking bacterial innate immunity to intestinal fibrosis. Gastroenterology 2010; 138: S-35.
-
(2010)
Gastroenterology
, vol.138
-
-
Rieder, F.1
Schirbel, A.2
Ouygan, Z.3
West, G.4
Rho, H.5
De La Motte, C.6
Fiocchi, C.7
-
11
-
-
77950995288
-
NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease
-
GAZOULI M, PACHOULA I, PANAYOTOU I, MANTZARIS G, CHROUSOS G, ANAGNOU NP, ROMA-GIANNIKOU E. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J Gastroenterol 2010; 16: 1753-1758.
-
(2010)
World J Gastroenterol
, vol.16
, pp. 1753-1758
-
-
Gazouli, M.1
Pachoula, I.2
Panayotou, I.3
Mantzaris, G.4
Chrousos, G.5
Anagnou, N.P.6
Roma-Giannikou, E.7
-
12
-
-
52949145981
-
Increased immune reactivity predicts aggressive complicating Crohn's disease in children
-
WESTERN REGIONAL PEDIATRIC IBD RESEARCH ALLIANCE; PEDIATRIC IBD COLLABORATIVE RESEARCH GROUP; WISCONSIN PEDIATRIC IBD ALLIANCE.
-
DUBINSKY MC, KUGATHASAN S, MEI L, PICORNELL Y, NEBEL J, WROBEL I, QUIROS A, SILBER G, WAHBEH G, KATZIR L, VASILIAUSKAS E, BAHAR R, OTLEY A, MACK D, EVANS J, ROSH J, HEMKER MO, LELEIKO N, CRANDALL W, LANGTON C, LANDERS C, TAYLOR KD, TARGAN SR, ROTTER JI, MARKOWITZ J, HYAMS J; WESTERN REGIONAL PEDIATRIC IBD RESEARCH ALLIANCE; PEDIATRIC IBD COLLABORATIVE RESEARCH GROUP; WISCONSIN PEDIATRIC IBD ALLIANCE. Increased immune reactivity predicts aggressive complicating Crohn's disease in children. Clin Gastroenterol Hepatol 2008; 6: 1105-1111.
-
(2008)
Clin Gastroenterol Hepatol
, vol.6
, pp. 1105-1111
-
-
Dubinsky, M.C.1
Kugathasan, S.2
Mei, L.3
Picornell, Y.4
Nebel, J.5
Wrobel, I.6
Quiros, A.7
Silber, G.8
Wahbeh, G.9
Katzir, L.10
Vasiliauskas, E.11
Bahar, R.12
Otley, A.13
MacK, D.14
Evans, J.15
Rosh, J.16
Hemker, M.O.17
Leleiko, N.18
Crandall, W.19
Langton, C.20
Landers, C.21
Taylor, K.D.22
Targan, S.R.23
Rotter, J.I.24
Markowitz, J.25
Hyams, J.26
more..
-
14
-
-
79955562519
-
Mesenchymal cell proliferation and programmed cell death: Key players in fibrogenesis and new targets for therapeutic intervention
-
LUNA J, MASAMUNT MC, LAWRANCE IC, SANS M. Mesenchymal cell proliferation and programmed cell death: key players in fibrogenesis and new targets for therapeutic intervention. Am J Physiol Gastrointest Liver Physiol 2011; 300: G703-G708.
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.300
-
-
Luna, J.1
Masamunt, M.C.2
Lawrance, I.C.3
Sans, M.4
-
15
-
-
84878608130
-
Available medical therapies do not affect development of major complications and need for surgery in Crohn's isease: Long-term prospective study on a population of 193 consecutive patients
-
ANGELUCCI E, CESARINI M, GENTILE P, NECOZIONE S, FIERI G, CAPRILLI R, LATELLA G. Available medical therapies do not affect development of major complications and need for surgery in Crohn's isease: Long-term prospective study on a population of 193 consecutive patients. J Crohns Colitis 2011; 5: S120-S121.
-
(2011)
J Crohns Colitis
, vol.5
-
-
Angelucci, E.1
Cesarini, M.2
Gentile, P.3
Necozione, S.4
Fieri, G.5
Caprilli, R.6
Latella, G.7
-
16
-
-
12344291265
-
Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
-
COSNES J, NION-LARMURIER I, BEAUGERIE L, AFCHAIN P, TIRET E, GENDRE JP. Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery. Gut 2005; 54: 237-241.
-
(2005)
Gut
, vol.54
, pp. 237-241
-
-
Cosnes, J.1
Nion-Larmurier, I.2
Beaugerie, L.3
Afchain, P.4
Tiret, E.5
Gendre, J.P.6
-
17
-
-
77950844753
-
Intestinal fibrosis in Crohn's disease: Medical treatment or surgery?
-
SPINELLI A, CORREALE C, SZABO H, MONTORSI M. Intestinal fibrosis in Crohn's disease: medical treatment or surgery? Curr Drug Targets 2010; 11: 242-248.
-
(2010)
Curr Drug Targets
, vol.11
, pp. 242-248
-
-
Spinelli, A.1
Correale, C.2
Szabo, H.3
Montorsi, M.4
-
21
-
-
38549159026
-
Cellular and molecular mechanisms of fibrosis
-
WYNN TA. Cellular and molecular mechanisms of fibrosis. J Pathol 2008; 214: 199-210.
-
(2008)
J Pathol
, vol.214
, pp. 199-210
-
-
Wynn, T.A.1
-
22
-
-
0032782848
-
Myofibroblasts I. Paracrine cells important in health and disease
-
POWELL DW, MIFFLIN RC, VALENTICH JD, CROWE SE, SAADA JI, WEST AB. Myofibroblasts I. Paracrine cells important in health and disease. Am J Physiol Cell Physiol 1999; 277: C1-C9.
-
(1999)
Am J Physiol Cell Physiol
, vol.277
-
-
Powell, D.W.1
Mifflin, R.C.2
Valentich, J.D.3
Crowe, S.E.4
Saada, J.I.5
West, A.B.6
-
23
-
-
0032833987
-
Myofibroblasts II. Intestinal subepithelial myofibroblasts
-
POWELL DW, MIFFLIN RC, VALENTICH JD, CROWE SE, SAADA JI, WEST AB. Myofibroblasts II. Intestinal subepithelial myofibroblasts. Am J Physiol Cell Physiol 1999; 277: C183-C201.
-
(1999)
Am J Physiol Cell Physiol
, vol.277
-
-
Powell, D.W.1
Mifflin, R.C.2
Valentich, J.D.3
Crowe, S.E.4
Saada, J.I.5
West, A.B.6
-
24
-
-
0036083712
-
Physiology and pathophysiology of the interstitial cells of Cajal: From bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal
-
SANDERS KM, ORDÖG T, WARD SM. Physiology and pathophysiology of the interstitial cells of Cajal: from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol 2002; 282: G747-G756.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.282
-
-
Sanders, K.M.1
Ordög, T.2
Ward, S.M.3
-
25
-
-
33645071313
-
Smad3-null mice lack interstitial cells of Cajal in the colonic wall
-
VETUSCHI A, SFERRA R, LATELLA G, D'ANGELO A, CATITTI V, ZANNINELLI G, CONTINENZA MA, GAUDIO E. Smad3-null mice lack interstitial cells of Cajal in the colonic wall. Eur J Clin Invest 2006; 36: 41-48.
-
(2006)
Eur J Clin Invest
, vol.36
, pp. 41-48
-
-
Vetuschi, A.1
Sferra, R.2
Latella, G.3
D'angelo, A.4
Catitti, V.5
Zanninelli, G.6
Continenza, M.A.7
Gaudio, E.8
-
26
-
-
33847350691
-
Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
-
WYNN TA. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007; 117: 524-529.
-
(2007)
J Clin Invest
, vol.117
, pp. 524-529
-
-
Wynn, T.A.1
-
27
-
-
0037657907
-
Human intestinal epithelial and smooth muscle cells are potent producers of IL-6
-
NG EK, PANESAR N, LONGO WE, SHAPIRO MJ, KAMINSKI DL, TOLMAN KC, MAZUSKI JE. Human intestinal epithelial and smooth muscle cells are potent producers of IL-6. Mediators Inflamm 2003; 12: 3-8.
-
(2003)
Mediators Inflamm
, vol.12
, pp. 3-8
-
-
Ng, E.K.1
Panesar, N.2
Longo, W.E.3
Shapiro, M.J.4
Kaminski, D.L.5
Tolman, K.C.6
Mazuski, J.E.7
-
28
-
-
0032742051
-
Rat liver myofibroblasts and hepatic stellate cells: Different cell populations of the fibroblast lineage with fibrogenic potential
-
KNITTEL T, KOBOLD D, SAILE B, GRUNDMANN A, NEUBAUER K, PISCAGLIA F, RAMADORI G. Rat liver myofibroblasts and hepatic stellate cells: different cell populations of the fibroblast lineage with fibrogenic potential. Gastroenterology 1999; 117: 1205-1221.
-
(1999)
Gastroenterology
, vol.117
, pp. 1205-1221
-
-
Knittel, T.1
Kobold, D.2
Saile, B.3
Grundmann, A.4
Neubauer, K.5
Piscaglia, F.6
Ramadori, G.7
-
29
-
-
0032954505
-
Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
-
APTE, M. HABER PS, DARBY SJ, RODGERS SC, MCCAUGHAN GW, KORSTEN MA, PIROLA RC, WILSON JS. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999; 44: 534-541.
-
(1999)
Gut
, vol.44
, pp. 534-541
-
-
Apte Haber M, P.S.1
Darby, S.J.2
Rodgers, S.C.3
McCaughan, G.W.4
Korsten, M.A.5
Pirola, R.C.6
Wilson, J.S.7
-
30
-
-
67649784378
-
Intestinal fibrosis in inflammatory bowel disease: Progress in basic and clinical science
-
RIEDER F, FIOCCHI C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol 2008; 24: 462-468.
-
(2008)
Curr Opin Gastroenterol
, vol.24
, pp. 462-468
-
-
Rieder, F.1
Fiocchi, C.2
-
31
-
-
0242405617
-
Endothelial-pericyte interactions in angiogenesis
-
GERHARDT H, BETSHOLTZ C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 2003; 314:15-23.
-
(2003)
Cell Tissue Res
, vol.314
, pp. 15-23
-
-
Gerhardt, H.1
Betsholtz, C.2
-
32
-
-
77953769774
-
Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis
-
FLIER SN, TANJORE H, KOKKOTOU EG, SUGIMOTO H, ZEISBERG M, KALLURI R. Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem 2010; 285: 20202-20212.
-
(2010)
J Biol Chem
, vol.285
, pp. 20202-20212
-
-
Flier, S.N.1
Tanjore, H.2
Kokkotou, E.G.3
Sugimoto, H.4
Zeisberg, M.5
Kalluri, R.6
-
33
-
-
80054976356
-
Inflammation-induced endothelial-to-mesenchymal transition: A novel mechanism of intestinal fibrosis
-
RIEDER F, KESSLER SP, WEST GA, BHILOCHA S, DE LA MOTTE C, SADLER TM, GOPALAN B, STYLIANOU E, FIOCCHI C. Inflammation-induced endothelial-to- mesenchymal transition: a novel mechanism of intestinal fibrosis. Am J Pathol 2011; 179: 2660-2673.
-
(2011)
Am J Pathol
, vol.179
, pp. 2660-2673
-
-
Rieder, F.1
Kessler, S.P.2
West, G.A.3
Bhilocha, S.4
De La Motte, C.5
Sadler, T.M.6
Gopalan, B.7
Stylianou, E.8
Fiocchi, C.9
-
34
-
-
77958187285
-
Intestinal stem cells
-
UMAR S. Intestinal stem cells. Curr Gastroenterol Rep 2010; 12: 340-348.
-
(2010)
Curr Gastroenterol Rep
, vol.12
, pp. 340-348
-
-
Umar, S.1
-
35
-
-
18444374439
-
In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions
-
ISHII G, SANGAI T, SUGIYAMA K, ITO T, HASEBE T, ENDOH Y, MAGAE J, OCHIAI A. In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions. Stem Cells 2005; 23: 699-706.
-
(2005)
Stem Cells
, vol.23
, pp. 699-706
-
-
Ishii, G.1
Sangai, T.2
Sugiyama, K.3
Ito, T.4
Hasebe, T.5
Endoh, Y.6
Magae, J.7
Ochiai, A.8
-
37
-
-
0033933804
-
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
-
VON LAMPE B, BARTHEL B, COUPLAND SE, RIECKEN EO, ROSEWICZ S. Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut 2000; 47: 63-73.
-
(2000)
Gut
, vol.47
, pp. 63-73
-
-
Von Lampe, B.1
Barthel, B.2
Coupland, S.E.3
Riecken, E.O.4
Rosewicz, S.5
-
38
-
-
33846180682
-
Matrix metalloproteinases in inflammatory bowel disease: Boon or a bane?
-
RAVI A, GARG P, SITARAMAN SV. Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Inflamm Bowel Dis 2007; 13: 97-107.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 97-107
-
-
Ravi, A.1
Garg, P.2
Sitaraman, S.V.3
-
39
-
-
34447101822
-
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease
-
MEIJER MJ, MIEREMET-OOMS MA, VAN HOGEZAND RA, LAMERS CB, HOMMES DW, VERSPAGET HW. Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease. World J Gastroenterol 2007; 13: 2960-2966.
-
(2007)
World J Gastroenterol
, vol.13
, pp. 2960-2966
-
-
Meijer, M.J.1
Mieremet-Ooms, M.A.2
Van Hogezand, R.A.3
Lamers, C.B.4
Hommes, D.W.5
Verspaget, H.W.6
-
40
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-β family signalling
-
DERYNCK R, ZHANG YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003; 425: 577-584.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
42
-
-
0029913624
-
Expression of transforming growth factor alpha and beta in colonic mucosa in inflammatory bowel disease
-
BABYATSKY MW, ROSSITER G, PODOLSKY DK. Expression of transforming growth factor alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996; 110: 975-984.
-
(1996)
Gastroenterology
, vol.110
, pp. 975-984
-
-
Babyatsky, M.W.1
Rossiter, G.2
Podolsky, D.K.3
-
44
-
-
84867145469
-
Animal models of intestinal fibrosis: New tools for the understanding of pathogenesis and therapy of human disease
-
RIEDER F, KESSLER S, SANS M, FIOCCHI C. Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease. Am J Physiol Gastrointest Liver Physiol 2012; 303: G786-G801.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.303
-
-
Rieder, F.1
Kessler, S.2
Sans, M.3
Fiocchi, C.4
-
45
-
-
22844451179
-
TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis
-
VALLANCE BA, GUNAWAN MI, HEWLETT B, BERCIK P, VAN KAMPEN C, GALEAZZI F, SIME PJ, GAULDIE J, COLLINS SM. TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis. Am J Physiol Gastrointest Liver Physiol 2005; 289: G116-G128.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.289
-
-
Vallance, B.A.1
Gunawan, M.I.2
Hewlett, B.3
Bercik, P.4
Van Kampen, C.5
Galeazzi, F.6
Sime, P.J.7
Gauldie, J.8
Collins, S.M.9
-
46
-
-
33645523595
-
Smad3 knock-out mice as a useful model to study intestinal fibrogenesis
-
ZANNINELLI G, VETUSCHI A, SFERRA R, D'ANGELO A, FRATTICCI A, CONTINENZA MA, CHIARAMONTE M, GAUDIO E, CAPRILLI R, LATELLA G. Smad3 knock-out mice as a useful model to study intestinal fibrogenesis. World J Gastroenterol 2006; 12: 1211-1218.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 1211-1218
-
-
Zanninelli, G.1
Vetuschi, A.2
Sferra, R.3
D'angelo, A.4
Fratticci, A.5
Continenza, M.A.6
Chiaramonte, M.7
Gaudio, E.8
Caprilli, R.9
Latella, G.10
-
47
-
-
58649088728
-
Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis
-
LATELLA G, VETUSCHI A, SFERRA R, ZANNINELLI G, D'ANGELO A, CATITTI V, CAPRILLI R, FLANDERS KC, GAUDIO E. Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis. Eur J Clin Invest 2009; 39: 145-156.
-
(2009)
Eur J Clin Invest
, vol.39
, pp. 145-156
-
-
Latella, G.1
Vetuschi, A.2
Sferra, R.3
Zanninelli, G.4
D'angelo, A.5
Catitti, V.6
Caprilli, R.7
Flanders, K.C.8
Gaudio, E.9
-
48
-
-
3042550759
-
Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
-
LAKOS G, TAKAGAWA S, CHEN SJ, FERREIRA AM, HAN G, MASUDA K, WANG XJ, DIPIETRO LA, VARGA J. Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol 2004; 165: 203-217.
-
(2004)
Am J Pathol
, vol.165
, pp. 203-217
-
-
Lakos, G.1
Takagawa, S.2
Chen, S.J.3
Ferreira, A.M.4
Han, G.5
Masuda, K.6
Wang, X.J.7
Dipietro, L.A.8
Varga, J.9
-
49
-
-
0036086293
-
Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice
-
ZHAO J, SHI W, WANG YL, CHEN H, BRINGAS P JR, DATTO MB, FREDERICK JP, WANG XF, WARBURTON D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 2002; 282: L585-L593.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
-
-
Zhao, J.1
Shi, W.2
Wang, Y.L.3
Chen, H.4
Bringas Jr., P.5
Datto, M.B.6
Frederick, J.P.7
Wang, X.F.8
Warburton, D.9
-
50
-
-
3242797424
-
Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction
-
INAZAKI K, KANAMARU Y, KOJIMA Y, SUEYOSHI N, OKUMURA K, KANEKO K, YAMASHIRO Y, OGAWA H, NAKAO A. Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int 2004; 66: 597-604.
-
(2004)
Kidney Int
, vol.66
, pp. 597-604
-
-
Inazaki, K.1
Kanamaru, Y.2
Kojima, Y.3
Sueyoshi, N.4
Okumura, K.5
Kaneko, K.6
Yamashiro, Y.7
Ogawa, H.8
Nakao, A.9
-
51
-
-
67650501166
-
Targeted disruption of Smad3 confers resistance to the development of DMN-induced hepatic fibrosis in mice
-
LATELLA G, VETUSCHI A, SFERRA R, CATITTI V, D'ANGELO A, ZANNINELLI G, FLANDERS KC, GAUDIO E. Targeted disruption of Smad3 confers resistance to the development of DMN-induced hepatic fibrosis in mice. Liver Int 2009, 29: 997-1009.
-
(2009)
Liver Int
, vol.29
, pp. 997-1009
-
-
Latella, G.1
Vetuschi, A.2
Sferra, R.3
Catitti, V.4
D'angelo, A.5
Zanninelli, G.6
Flanders, K.C.7
Gaudio, E.8
-
52
-
-
2942535966
-
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
-
FUKASAWA H, YAMAMOTO T, TOGAWA A, OHASHI N, FUJIGAKI Y, ODA T, UCHIDA C, KITAGAWA K, HATTORI T, SUZUKI S, KITAGAWA M, HISHIDA A. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci USA 2004; 101: 8687-8692.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8687-8692
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
Oda, T.6
Uchida, C.7
Kitagawa, K.8
Hattori, T.9
Suzuki, S.10
Kitagawa, M.11
Hishida, A.12
-
53
-
-
0037716406
-
Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats
-
DOOLEY S, HAMZAVI J, BREITKOPF K, WIERCINSKA E, SAID HM, LORENZEN J, TEN DIJKE P, GRESSNER AM. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology 2003; 125: 178-191.
-
(2003)
Gastroenterology
, vol.125
, pp. 178-191
-
-
Dooley, S.1
Hamzavi, J.2
Breitkopf, K.3
Wiercinska, E.4
Said, H.M.5
Lorenzen, J.6
Ten Dijke, P.7
Gressner, A.M.8
-
54
-
-
0037133596
-
Deficient Smad7 expression: A putative molecular defect in scleroderma
-
DONG C, ZHU S, WANG T, YOON W, LI Z, ALVAREZ RJ, TEN DIJKE P, WHITE B, WIGLEY FM, GOLDSCHMIDT-CLERMONT PJ. Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc Natl Acad Sci USA 2002; 99: 3908-3913.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3908-3913
-
-
Dong, C.1
Zhu, S.2
Wang, T.3
Yoon, W.4
Li, Z.5
Alvarez, R.J.6
Ten Dijke, P.7
White, B.8
Wigley, F.M.9
Goldschmidt-Clermont, P.J.10
-
55
-
-
0032719815
-
Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
-
NAKAO A, FUJII M, MATSUMURA R, KUMANO K, SAITO Y, MIYAZONO K, IWAMOTO I. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999; 104: 5-11.
-
(1999)
J Clin Invest
, vol.104
, pp. 5-11
-
-
Nakao, A.1
Fujii, M.2
Matsumura, R.3
Kumano, K.4
Saito, Y.5
Miyazono, K.6
Iwamoto, I.7
-
56
-
-
54349102070
-
Prevention and treatment of intestinal fibrosis: Up-regulate smad7 or inhibit smad3 expression
-
LATELLA G, ZANNINELLI G. Prevention and treatment of intestinal fibrosis: up-regulate smad7 or inhibit smad3 expression. Eur J Clin Invest 2008; 38: 878-880.
-
(2008)
Eur J Clin Invest
, vol.38
, pp. 878-880
-
-
Latella, G.1
Zanninelli, G.2
-
57
-
-
66649106333
-
Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures
-
DI SABATINO A, JACKSON CL, PICKARD KM, BUCKLEY M, ROVEDATTI L, LEAKEY NA, PICARIELLO L, CAZZOLA P, MONTELEONE G, TONELLI F, CORAZZA GR, MACDONALD TT, PENDER SL. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut 2009; 58: 777-789.
-
(2009)
Gut
, vol.58
, pp. 777-789
-
-
Sabatino A, D.I.1
Jackson, C.L.2
Pickard, K.M.3
Buckley, M.4
Rovedatti, L.5
Leakey, N.A.6
Picariello, L.7
Cazzola, P.8
Monteleone, G.9
Tonelli, F.10
Corazza, G.R.11
MacDonald, T.T.12
Pender, S.L.13
-
58
-
-
0032982486
-
A novel role of activin in inflammation and repair
-
MUNZ B, HÜBNER G, TRETTER Y, ALZHEIMER C, WERNER S. A novel role of activin in inflammation and repair. J Endocrinol 1999; 161: 187-193.
-
(1999)
J Endocrinol
, vol.161
, pp. 187-193
-
-
Munz, B.1
Hübner, G.2
Tretter, Y.3
Alzheimer, C.4
Werner, S.5
-
59
-
-
33744515391
-
Roles of activin in tissue repair, fibrosis, and inflammatory disease
-
WERNER S, ALZHEIMER C. Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokine Growth Factor Rev 2006; 17: 157-171.
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 157-171
-
-
Werner, S.1
Alzheimer, C.2
-
60
-
-
0031225015
-
Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
-
GROTENDORST GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997; 8: 171-179.
-
(1997)
Cytokine Growth Factor Rev
, vol.8
, pp. 171-179
-
-
Grotendorst, G.R.1
-
61
-
-
0036775477
-
Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?
-
BLOM IE, GOLDSCHMEDING R, LEASK A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002; 21: 473-482.
-
(2002)
Matrix Biol
, vol.21
, pp. 473-482
-
-
Blom, I.E.1
Goldschmeding, R.2
Leask, A.3
-
62
-
-
0035677983
-
Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease
-
KUMAGAI S, OHTANI H, NAGAI T, FUNA K, HIWATASHI NO, SHIMOSEGAWA, NAGURA H. Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease. Tohoku J Exp Med 2001; 195: 21-33.
-
(2001)
Tohoku J Exp Med
, vol.195
, pp. 21-33
-
-
Kumagai, S.1
Ohtani, H.2
Nagai, T.3
Funa, K.4
Hiwatashi, N.O.5
Shimosegawa6
Nagura, H.7
-
63
-
-
2942682928
-
Regulation of PDGF and its receptors in fibrotic diseases
-
BONNER JC. REGULATION OF PDGF AND ITS RECEPTORS IN FIBROTIC DISEASES. Cytokine Growth Factor Reviews 2004; 15: 255-273.
-
(2004)
Cytokine Growth Factor Reviews
, vol.15
, pp. 255-273
-
-
Bonner, J.C.1
-
64
-
-
36148998002
-
Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth
-
SIMMONS JG, LING Y, WILKINS H, FULLER CR, D'ERCOLE AJ, FAGIN J, LUND PK. Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth. Am J Physiol Gastrointest Liver Physiol 2007; 293: G995-G1003.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.293
-
-
Simmons, J.G.1
Ling, Y.2
Wilkins, H.3
Fuller, C.R.4
D'ercole, A.J.5
Fagin, J.6
Lund, P.K.7
-
65
-
-
0035038445
-
Insulin-like growth factor i and insulinlike growth factor binding protein 5 in Crohn's disease
-
ZIMMERMANN EM, LI L, HOU YT, MOHAPATRA NK, PUCILOWSKA JB. Insulin-like growth factor I and insulinlike growth factor binding protein 5 in Crohn's disease. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1022-G1029.
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.280
-
-
Zimmermann, E.M.1
Li, L.2
Hou, Y.T.3
Mohapatra, N.K.4
Pucilowska, J.B.5
-
67
-
-
57349194661
-
Inflammatory cytokines augments TGFbeta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I
-
LIU X. Inflammatory cytokines augments TGFbeta1-induced epithelial-mesenchymal transition in A549 cells by up-regulating TbetaR-I. Cell Motil Cytoskeleton 2008; 65: 935-944.
-
(2008)
Cell Motil Cytoskeleton
, vol.65
, pp. 935-944
-
-
Liu, X.1
-
68
-
-
78650199530
-
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts
-
SPONHEIM J, POLLHEIMER J, OLSEN T, BALOGH J, HAMMARSTRÖM C, LOOS T, KASPRZYCKA M, SØRENSEN DR, NILSEN HR, KÜCHLER AM, VATN MH, HARALDSEN G. Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts. Am J Pathol 2010; 177: 2804-2815.
-
(2010)
Am J Pathol
, vol.177
, pp. 2804-2815
-
-
Sponheim, J.1
Pollheimer, J.2
Olsen, T.3
Balogh, J.4
Hammarström, C.5
Loos, T.6
Kasprzycka, M.7
SØrensen, D.R.8
Nilsen, H.R.9
Küchler, A.M.10
Vatn, M.H.11
Haraldsen, G.12
-
70
-
-
67650935391
-
Critical role of IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection
-
JA, BOOTH AJ, LU G, WOOD SC, PINSKY DJ, BISHOP DK. Critical role of IL-6 in hypertrophy and fibrosis in chronic cardiac allograft rejection. Am J Transplant 2009; 9: 1773-1783.
-
(2009)
Am J Transplant
, vol.9
, pp. 1773-1783
-
-
Booth, A.J.1
Lu, G.2
Wood, S.C.3
Pinsky, D.J.4
Bishop, D.K.5
-
71
-
-
73349121322
-
Interleukin (IL)-6 modulates transforming growth factor -beta expression in skin and dermal fibroblasts from IL-6-deficient mice
-
LUCKETT-CHASTAIN LR, GALLUCCI RM. Interleukin (IL)-6 modulates transforming growth factor -beta expression in skin and dermal fibroblasts from IL-6-deficient mice. Br J Dermatol 2009; 161: 237-248.
-
(2009)
Br J Dermatol
, vol.161
, pp. 237-248
-
-
Luckett-Chastain, L.R.1
Gallucci, R.M.2
-
72
-
-
30044449492
-
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
-
FICHTNER-FEIGL S, STROBER W, KAWAKAMI K, PURI RK, KITANI A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med 2006; 12: 99-106.
-
(2006)
Nat Med
, vol.12
, pp. 99-106
-
-
Fichtner-Feigl, S.1
Strober, W.2
Kawakami, K.3
Puri, R.K.4
Kitani, A.5
-
74
-
-
27744461703
-
Tumor Necrosis Factor (TNF) a Increases Collagen Accumulation and Proliferation in Intestinal Myofibroblasts via TNF Receptor 2
-
THEISS AL, SIMMONS JG, JOBIN C, LUND PK. Tumor Necrosis Factor (TNF) a Increases Collagen Accumulation and Proliferation in Intestinal Myofibroblasts via TNF Receptor 2. J Biol Chem 2005; 280: 36099-36109.
-
(2005)
J Biol Chem
, vol.280
, pp. 36099-36109
-
-
Theiss, A.L.1
Simmons, J.G.2
Jobin, C.3
Lund, P.K.4
-
75
-
-
33745845825
-
139 Physiology of local renin-angiotensin systems
-
PAUL M, POYAN MEHR A, KREUTZ R. 139 Physiology of local renin-angiotensin systems. Physiol Rev 2006; 86:747-803.
-
(2006)
Physiol Rev
, vol.86
, pp. 747-803
-
-
Paul, M.1
Poyan Mehr, A.2
Kreutz, R.3
-
76
-
-
0036146790
-
Immunohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa
-
HIRASAWA K, SATO Y, HOSODA Y, YAMAMOTO T, HANAI H. Immunohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa. J Histochem Cytochem 2002; 50: 275-282.
-
(2002)
J Histochem Cytochem
, vol.50
, pp. 275-282
-
-
Hirasawa, K.1
Sato, Y.2
Hosoda, Y.3
Yamamoto, T.4
Hanai, H.5
-
77
-
-
77949536656
-
Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy
-
BADER M. Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy. Annu Rev Pharmacol Toxicol 2010; 50: 439-465.
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 439-465
-
-
Bader, M.1
-
78
-
-
30344442801
-
Angiotensin II: A key factor in the inflammatory and fibrotic response in kidney diseases
-
RUIZ-ORTEGA M, RUPEREZ M, ESTEBAN V, RODRÍGUEZ-VITA J, SÁNCHEZ-LÓPEZ E, CARVAJAL G, EGIDO J. Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases. Nephrol Dial Transpl 2006; 21: 16-20.
-
(2006)
Nephrol Dial Transpl
, vol.21
, pp. 16-20
-
-
Ruiz-Ortega, M.1
Ruperez, M.2
Esteban, V.3
Rodríguez-Vita, J.4
Sánchez-López, E.5
Carvajal, G.6
Egido, J.7
-
79
-
-
0025231985
-
Increased colonic mucosal angiotensin i and II concentration in Crohn's colitis
-
JASZEWSKI R, TOLIA V, EHRINPREIS MN, BODZIN JH, PELEMAN RR, KORLIPARA R, WEINSTOCK JV. Increased colonic mucosal angiotensin I and II concentration in Crohn's colitis. Gastroenterology 1990; 98: 1543-1548.
-
(1990)
Gastroenterology
, vol.98
, pp. 1543-1548
-
-
Jaszewski, R.1
Tolia, V.2
Ehrinpreis, M.N.3
Bodzin, J.H.4
Peleman, R.R.5
Korlipara, R.6
Weinstock, J.V.7
-
80
-
-
14544296574
-
Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice
-
INOKUCHI Y, MOROHASHI T, KAWANA I, NAGASHIMA Y, KIHARA M, UMEMURA S. Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice. Gut 2005; 54: 349-356.
-
(2005)
Gut
, vol.54
, pp. 349-356
-
-
Inokuchi, Y.1
Morohashi, T.2
Kawana, I.3
Nagashima, Y.4
Kihara, M.5
Umemura, S.6
-
81
-
-
4644308778
-
Prevention of fibrosis in experimental colitis by captopril: The role of TGFß1
-
D WENGROWER, G ZANNINELLI, O PAPPO, G LATELLA, M SESTIERI, A. VILLANOVA, Y FAITELSON, M PINES, E GOLDIN. Prevention of fibrosis in experimental colitis by captopril: the role of TGFß1. Inflamm Bowel Dis 2004; 10: 536-545.
-
(2004)
Inflamm Bowel Dis
, vol.10
, pp. 536-545
-
-
Wengrower, D.1
Zanninelli, G.2
Pappo, O.3
Latella, G.4
Sestieri, M.5
Villanova, A.6
Faitelson, Y.7
Pines, M.8
Goldin, E.9
-
82
-
-
84856403018
-
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats
-
WENGROWER D, ZANNINELLI G, LATELLA G, NECOZIONE S, METANES I, ISRAELI E, LYSY J, PINES M, PAPO O, GOLDIN E. Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats. Can J Gastroenterol 2012; 26: 33-39.
-
(2012)
Can J Gastroenterol
, vol.26
, pp. 33-39
-
-
Wengrower, D.1
Zanninelli, G.2
Latella, G.3
Necozione, S.4
Metanes, I.5
Israeli, E.6
Lysy, J.7
Pines, M.8
Papo, O.9
Goldin, E.10
-
84
-
-
75949103899
-
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
-
MARGADANT C, SONNENBERG A. Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing. EMBO Rep 2010; 11: 97-105.
-
(2010)
EMBO Rep
, vol.11
, pp. 97-105
-
-
Margadant, C.1
Sonnenberg, A.2
-
85
-
-
33846569938
-
Targeting mammalian target of rapamycin (mTOR) for health and diseases
-
TSANG CK, QI H, LIU LF, ZHENG XF. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 2007; 12: 112-124.
-
(2007)
Drug Discov Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.4
-
86
-
-
74049137551
-
Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis
-
WANG S, WILKES MC, LEOF EB, HIRSCHBERG R. Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. Am J Physiol Renal Physiol 2010; 298: F142-F149.
-
(2010)
Am J Physiol Renal Physiol
, vol.298
-
-
Wang, S.1
Wilkes, M.C.2
Leof, E.B.3
Hirschberg, R.4
-
87
-
-
33845938244
-
Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent?
-
POULALHON N, FARGE D, ROOS N, TACHEAU C, NEUZILLET C, MICHEL L, MAUVIEL A, VERRECCHIA F. Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamycin. A direct role as an antifibrotic agent? J Biol Chem 2006; 281: 33045-33052.
-
(2006)
J Biol Chem
, vol.281
, pp. 33045-33052
-
-
Poulalhon, N.1
Farge, D.2
Roos, N.3
Tacheau, C.4
Neuzillet, C.5
Michel, L.6
Mauviel, A.7
Verrecchia, F.8
-
88
-
-
78549260675
-
Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin
-
OSMAN B, AKOOL EL-S, DOLLER A, MÜLLER R, PFEILSCHIFTER J, EBERHARDT W. Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin. Biochem Pharmacol 2011; 81: 134-143.
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 134-143
-
-
Osman, B.1
Akool, E.L.-S.2
Doller, A.3
Müller, R.4
Pfeilschifter, J.5
Eberhardt, W.6
-
89
-
-
72049105867
-
The role of the mammalian target of rapamycin (mTOR) in renal disease
-
LIEBERTHAL W, LEVINE JS. The role of the mammalian target of rapamycin (mTOR) in renal disease. J Am Soc Nephrol 2009; 20: 2493-2502.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 2493-2502
-
-
Lieberthal, W.1
Levine, J.S.2
-
90
-
-
0035923672
-
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors
-
XU HE, LAMBERT MH, MONTANA VG, PLUNKET KD, MOORE LB, COLLINS JL, OPLINGER JA, KLIEWER SA, GAMPE RT, MCKEE DD, MOORE JT, WILLSON TM. Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 2001; 98: 13919-13924.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13919-13924
-
-
He, X.U.1
Lambert, M.H.2
Montana, V.G.3
Plunket, K.D.4
Moore, L.B.5
Collins, J.L.6
Oplinger, J.A.7
Kliewer, S.A.8
Gampe, R.T.9
McKee, D.D.10
Moore, J.T.11
Willson, T.M.12
-
91
-
-
33751362282
-
The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD)
-
ROUSSEAUX C, DESREUMAUX P. The peroxisome-proliferator-activated gamma receptor and chronic inflammatory bowel disease (PPARgamma and IBD). J Soc Biol 2006; 200: 121-131.
-
(2006)
J Soc Biol
, vol.200
, pp. 121-131
-
-
Rousseaux, C.1
Desreumaux, P.2
-
92
-
-
33749341729
-
1/Smad3-signaling in human hepatic stellate cells
-
ZHAO C, CHEN W, YANG L, CHEN L, STIMPSON SA, DIEHL AM. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun 2006; 350: 385-391.
-
(2006)
Biochem Biophys Res Commun
, vol.350
, pp. 385-391
-
-
Zhao, C.1
Chen, W.2
Yang, L.3
Chen, L.4
Stimpson, S.A.5
Diehl, A.M.6
-
93
-
-
68649123084
-
Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor andextracellular matrix in hypertrophic scar fibroblasts in vitro
-
ZHANG GY, CHENG T, ZHENG MH, YI CG, PAN H, LI ZJ, CHEN XL, YU Q, JIANG LF, ZHOU FY, LI XY, YANG JQ, CHU TG, GAO WY. Activation of peroxisome proliferator-activated receptor-gamma inhibits transforming growth factor-beta1 induction of connective tissue growth factor andextracellular matrix in hypertrophic scar fibroblasts in vitro. Arch Dermatol Res 2009; 301: 515-522.
-
(2009)
Arch Dermatol Res
, vol.301
, pp. 515-522
-
-
Zhang, G.Y.1
Cheng, T.2
Zheng, M.H.3
Yi, C.G.4
Pan, H.5
Li, Z.J.6
Chen, X.L.7
Yu, Q.8
Jiang, L.F.9
Zhou, F.Y.10
Li, X.Y.11
Yang, J.Q.12
Chu, T.G.13
Gao, W.Y.14
-
94
-
-
79958250108
-
What are the mechanisms of fibrosis in IBD?
-
LUND PK, RIBY RJ. What are the mechanisms of fibrosis in IBD? Inflamm Bowel Dis 2008; 14: S127-S128.
-
(2008)
Inflamm Bowel Dis
, vol.14
-
-
Lund, P.K.1
Riby, R.J.2
-
95
-
-
78649506169
-
News from the "5th International Meeting on Inflammatory Bowel Diseases" CAPRI 2010
-
LATELLA G, FIOCCHI C, CAPRILI R. News from the "5th International Meeting on Inflammatory Bowel Diseases" CAPRI 2010. J Crohns Colitis 2010; 4: 690-702.
-
(2010)
J Crohns Colitis
, vol.4
, pp. 690-702
-
-
Latella, G.1
Fiocchi, C.2
Caprili, R.3
-
96
-
-
84860835848
-
Treatment of inflammatory bowel diseases: To heal the wound or to heal the sick?
-
CAPRILLI R, LATELLA G, FRIERI G. Treatment of inflammatory bowel diseases: to heal the wound or to heal the sick? J Crohns Colitis 2012; 6: 621-625.
-
(2012)
J Crohns Colitis
, vol.6
, pp. 621-625
-
-
Caprilli, R.1
Latella, G.2
Frieri, G.3
-
97
-
-
78951487583
-
In favour of early surgery in Crohn's disease: A hypothesis to be tested
-
LATELLA G, CAPRILLI R, TRAVIS S. In favour of early surgery in Crohn's disease: a hypothesis to be tested. J Crohn Colitis 2011: 5; 1-4.
-
(2011)
J Crohn Colitis
, vol.5
, pp. 1-4
-
-
Latella, G.1
Caprilli, R.2
Travis, S.3
-
98
-
-
75149116327
-
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations
-
EUROPEAN CROHN'S AND COLITIS ORGANISATION (ECCO)
-
VAN ASSCHE G, DIGNASS A, REINISCH W, VAN DER WOUDE CJ, STURM A, DE VOS M, GUSLANDI M, OLDENBURG B, DOTAN I, MARTEAU P, ARDIZZONE A, BAUMGART DC, D'HAENS G, GIONCHETTI P, PORTELA F, VUCELIC B, SÖDERHOLM J, ESCHER J, KOLETZKO S, KOLHO KL, LUKAS M, MOTTET C, TILG H, VERMEIRE S, CARBONNEL F, COLE A, NOVACEK G, REINSHAGEN M, TSIANOS E, HERRLINGER K, OLDENBURG B, BOUHNIK Y, KIESSLICH R, STANGE E, TRAVIS S, LINDSAY J; EUROPEAN CROHN'S AND COLITIS ORGANISATION (ECCO). The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations. J Crohn Colitis 2010; 4: 63-101.
-
(2010)
J Crohn Colitis
, vol.4
, pp. 63-101
-
-
Van Assche, G.1
Dignass, A.2
Reinisch, W.3
Van Der Woude, C.J.4
Sturm, A.5
De Vos, M.6
Guslandi, M.7
Oldenburg, B.8
Dotan, I.9
Marteau, P.10
Ardizzone, A.11
Baumgart, D.C.12
D'haens, G.13
Gionchetti, P.14
Portela, F.15
Vucelic, B.16
Söderholm, J.17
Escher, J.18
Koletzko, S.19
Kolho, K.L.20
Lukas, M.21
Mottet, C.22
Tilg, H.23
Vermeire, S.24
Carbonnel, F.25
Cole, A.26
Novacek, G.27
Reinshagen, M.28
Tsianos, E.29
Herrlinger, K.30
Oldenburg, B.31
Bouhnik, Y.32
Kiesslich, R.33
Stange, E.34
Travis, S.35
Lindsay, J.36
more..
-
99
-
-
75149161836
-
The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management
-
EUROPEAN CROHN'S AND COLITIS ORGANISATION (ECCO)
-
DIGNASS A, VAN ASSCHE G, LINDSAY JO, LÉMANN M, SÖDERHOLM J, COLOMBEL JF, DANESE S, D'HOORE A, GASSULL M, GOMOLLÓN F, HOMMES DW, MICHETTI P, O'MORAIN C, ORESLAND T, WINDSOR A, STANGE EF, TRAVIS SP; EUROPEAN CROHN'S AND COLITIS ORGANISATION (ECCO). The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management. J Crohn Colitis 2010: 4: 28-62.
-
(2010)
J Crohn Colitis
, vol.4
, pp. 28-62
-
-
Dignass, A.1
Van Assche, G.2
Lindsay, J.O.3
Lémann, M.4
Söderholm, J.5
Colombel, J.F.6
Danese, S.7
D'hoore, A.8
Gassull, M.9
Gomollón, F.10
Hommes, D.W.11
Michetti, P.12
O'morain, C.13
Oresland, T.14
Windsor, A.15
Stange, E.F.16
Travis, S.P.17
-
100
-
-
77953709050
-
Outcome of medical treatment of stricturing and penetrating Crohn's disease: A retrospective study
-
SAMIMI R, FLASAR MH, KAVIC S, TRACY K, CROSS RK. Outcome of medical treatment of stricturing and penetrating Crohn's disease: a retrospective study. Inflamm Bowel Dis 2010; 16: 1187-1194.
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1187-1194
-
-
Samimi, R.1
Flasar, M.H.2
Kavic, S.3
Tracy, K.4
Cross, R.K.5
-
101
-
-
22744453976
-
Evolution of clinical behaviour in Crohn's disease: Predictive factors of penetrating complications
-
PAPI C, FESTA V, FAGNANI C, STAZI A, ANTONELLI G, MORETTI A, KOCH M, CAPURSO L. Evolution of clinical behaviour in Crohn's disease: predictive factors of penetrating complications. Digest Liver Dis 2005; 37: 247-253.
-
(2005)
Digest Liver Dis
, vol.37
, pp. 247-253
-
-
Papi, C.1
Festa, V.2
Fagnani, C.3
Stazi, A.4
Antonelli, G.5
Moretti, A.6
Koch, M.7
Capurso, L.8
-
102
-
-
72949107361
-
Review article: Anti-fibrotic agents for the treatment of Crohn's disease-lessons learnt from other diseases
-
SZABÒ H, FIORINO G, SPINELLI A, ROVIDA S, REPICI A, MALESCI AC, DANESE S. Review article: anti-fibrotic agents for the treatment of Crohn's disease-lessons learnt from other diseases. Aliment Pharmacol Ther 2010; 31: 189-201.
-
(2010)
Aliment Pharmacol Ther
, vol.31
, pp. 189-201
-
-
Szabò, H.1
Fiorino, G.2
Spinelli, A.3
Rovida, S.4
Repici, A.5
Malesci, A.C.6
Danese, S.7
-
103
-
-
36248993397
-
Retroperitoneal fibrosis: Evolving concepts
-
VAGLIO A, PALMISANO A, CORRADI D, SALVARANI C, BUZIO C. Retroperitoneal fibrosis: evolving concepts. Rheum Dis Clin North Am 2007; 33: 803-817.
-
(2007)
Rheum Dis Clin North Am
, vol.33
, pp. 803-817
-
-
Vaglio, A.1
Palmisano, A.2
Corradi, D.3
Salvarani, C.4
Buzio, C.5
-
104
-
-
61349192362
-
Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis
-
BADEA I, TAYLOR M, ROSENBERG A, FOLDVARI M. Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis. Rheumatology 2009; 48: 213-221.
-
(2009)
Rheumatology
, vol.48
, pp. 213-221
-
-
Badea, I.1
Taylor, M.2
Rosenberg, A.3
Foldvari, M.4
-
106
-
-
0028867655
-
Corticosteroids increase procollagen gene expression synthesis, and secretion by human intestinal smooth muscle cells
-
GRAHAM MF, WILLEY A, ADAMS J, DIEGELMANN RF. Corticosteroids increase procollagen gene expression, synthesis, and secretion by human intestinal smooth muscle cells. Gastroenterology 1995; 109: 1454-1461.
-
(1995)
Gastroenterology
, vol.109
, pp. 1454-1461
-
-
Graham, M.F.1
Willey, A.2
Adams, J.3
Diegelmann, R.F.4
-
107
-
-
31144447787
-
Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis
-
VIDELA S, VILASECA J, MEDINA C, MOURELLE M, GUARNER F, SALAS A, MALAGELADA JR. Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis. J Pharmacol Exp Ther 2006; 316: 940-945.
-
(2006)
J Pharmacol Exp Ther
, vol.316
, pp. 940-945
-
-
Videla, S.1
Vilaseca, J.2
Medina, C.3
Mourelle, M.4
Guarner, F.5
Salas, A.6
Malagelada, J.R.7
-
108
-
-
19544385100
-
Immunosuppressive treatment of chronic periaortitis: A retrospective study of 20 patients with chronic periaortitis and a review of the literature
-
WARNATZ K, KESKIN AG, UHL M, SCHOLZ C, KATZENWADEL A, VAITH P, PETER HH, WALKER UA. Immunosuppressive treatment of chronic periaortitis: a retrospective study of 20 patients with chronic periaortitis and a review of the literature. Ann Rheum Dis 2005; 64: 828-833.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 828-833
-
-
Warnatz, K.1
Keskin, A.G.2
Uhl, M.3
Scholz, C.4
Katzenwadel, A.5
Vaith, P.6
Peter, H.H.7
Walker, U.A.8
-
109
-
-
4444379671
-
Experience with azathioprine in systemic sclerosis associated with interstitial lung disease
-
Dheda K, Lalloo UG, Cassim B, Mody GM. Experience with azathioprine in systemic sclerosis associated with interstitial lung disease. Clin Rheumatol 2004; 23: 306-309.
-
(2004)
Clin Rheumatol
, vol.23
, pp. 306-309
-
-
Dheda, K.1
Lalloo, U.G.2
Cassim, B.3
Mody, G.M.4
-
110
-
-
68349137946
-
Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: A meta-analysis
-
PEYRIN-BIROULET L, DELTENRE P, ARDIZZONE S, D'HAENS G, HANAUER SB, HERFARTH H, LÉMANN M, COLOMBEL JF. Azathioprine and 6-mercaptopurine for the prevention of postoperative recurrence in Crohn's disease: a meta-analysis .Am J Gastroenterol 2009; 104: 2089-2096.
-
(2009)
Am J Gastroenterol
, vol.104
, pp. 2089-2096
-
-
Peyrin-Biroulet, L.1
Deltenre, P.2
Ardizzone, S.3
D'haens, G.4
Hanauer, S.B.5
Herfarth, H.6
Lémann, M.7
Colombel, J.F.8
-
111
-
-
33646578682
-
Intestinal strictures complicating initially successful infliximab treatment for luminal Crohn's disease
-
A315
-
VASILOPOULOS S, KUGATHASAN S, SAEIAN K, EMMONS JE, HOGAN WJ, OTTERSON MF, ET AL. Intestinal strictures complicating initially successful infliximab treatment for luminal Crohn's disease. Am J Gastroenterol 2000; 95: 2503 (A315).
-
(2000)
Am J Gastroenterol
, vol.95
, pp. 2503
-
-
Vasilopoulos, S.1
Kugathasan, S.2
Saeian, K.3
Emmons, J.E.4
Hogan, W.J.5
Otterson, M.F.6
-
112
-
-
0000487030
-
Complete bowel obstruction following initial response to infliximab therapy for Crohn's disease: A series of a newly described complication
-
2974
-
TOY LS, SCHERL EJ, KORNBLUTH A, KORNBLUTH A, MARION JF, GREENSTEIN AJ, ET AL. Complete bowel obstruction following initial response to infliximab therapy for Crohn's disease: A series of a newly described complication. Gastroenterology 2000; 118(Suppl 2, Part 1): A569 (2974).
-
(2000)
Gastroenterology
, vol.118
, Issue.SUPPL. 2 AND PART 1
-
-
Toy, L.S.1
Scherl, E.J.2
Kornbluth, A.3
Kornbluth, A.4
Marion, J.F.5
Greenstein, A.J.6
-
113
-
-
33646581382
-
Factors associated with the development of intestinal strictures or obstructions in patients with Crohn's disease
-
LICHTENSTEIN GR, OLSON A, TRAVERS S, DIAMOND RH, CHEN DM, PRITCHARD ML, FEAGAN BG, COHEN RD, SALZBERG BA, HANAUER SB, SANDBORN WJ. Factors associated with the development of intestinal strictures or obstructions in patients with Crohn's disease. Am J Gastroenterol 2006; 101: 1030-1038.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 1030-1038
-
-
Lichtenstein, G.R.1
Olson, A.2
Travers, S.3
Diamond, R.H.4
Chen, D.M.5
Pritchard, M.L.6
Feagan, B.G.7
Cohen, R.D.8
Salzberg, B.A.9
Hanauer, S.B.10
Sandborn, W.J.11
-
114
-
-
34447093806
-
Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies
-
DI SABATINO A, PENDER SL, JACKSON CL, PROTHERO JD, GORDON JN, PICARIELLO L, ROVEDATTI L, DOCENA G, MONTELEONE G, RAMPTON DS, TONELLI F, CORAZZA GR, MACDONALD TT. Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology 2007; 133: 137-149.
-
(2007)
Gastroenterology
, vol.133
, pp. 137-149
-
-
Sabatino A, D.I.1
Pender, S.L.2
Jackson, C.L.3
Prothero, J.D.4
Gordon, J.N.5
Picariello, L.6
Rovedatti, L.7
Docena, G.8
Monteleone, G.9
Rampton, D.S.10
Tonelli, F.11
Corazza, G.R.12
MacDonald, T.T.13
-
115
-
-
2442657641
-
Infliximab downregulates basic fibroblast growth factor and vascular endothelial growth factor in Crohn's disease patients
-
DI SABATINO A, CICCOCIOPPO R, BENAZZATO L, STURNIOLO GC, CORAZZA GR. Infliximab downregulates basic fibroblast growth factor and vascular endothelial growth factor in Crohn's disease patients. Aliment Pharmacol Ther 2004; 19: 1019-1024.
-
(2004)
Aliment Pharmacol Ther
, vol.19
, pp. 1019-1024
-
-
Sabatino A, D.I.1
Ciccocioppo, R.2
Benazzato, L.3
Sturniolo, G.C.4
Corazza, G.R.5
-
116
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT i randomised trial
-
ACCENT I STUDY GROUP
-
HANAUER SB, FEAGAN BG, LICHTENSTEIN GR, MAYER LF, SCHREIBER S, COLOMBEL JF, RACHMILEWITZ D, WOLF DC, OLSON A, BAO W, RUTGEERTS P; ACCENT I STUDY GROUP. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-1549.
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
Mayer, L.F.4
Schreiber, S.5
Colombel, J.F.6
Rachmilewitz, D.7
Wolf, D.C.8
Olson, A.9
Bao, W.10
Rutgeerts, P.11
-
117
-
-
17144388945
-
Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease
-
LICHTENSTEIN GR, YAN S, BALA M, BLANK M, SANDS BE. Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease. Gastroenterology 2005; 128: 862-869.
-
(2005)
Gastroenterology
, vol.128
, pp. 862-869
-
-
Lichtenstein, G.R.1
Yan, S.2
Bala, M.3
Blank, M.4
Sands, B.E.5
-
118
-
-
63849101007
-
Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: Results from a single-centre cohort
-
SCHNITZLER F, FIDDER H, FERRANTE M, NOMAN M, ARIJS I, VAN ASSCHE G, HOFFMAN I, VAN STEEN K, VERMEIRE S, RUTGEERTS P. Long-term outcome of treatment with infliximab in 614 patients with Crohn's disease: results from a single-centre cohort. Gut 2009; 58: 492-500.
-
(2009)
Gut
, vol.58
, pp. 492-500
-
-
Schnitzler, F.1
Fidder, H.2
Ferrante, M.3
Noman, M.4
Arijs, I.5
Van Assche, G.6
Hoffman, I.7
Van Steen, K.8
Vermeire, S.9
Rutgeerts, P.10
-
119
-
-
80955178844
-
Surgery for adult Crohn's disease: What is the actual risk?
-
BOUGUEN G, PEYRIN-BIROULET L. Surgery for adult Crohn's disease: what is the actual risk? Gut 2011; 60: 1178-1181.
-
(2011)
Gut
, vol.60
, pp. 1178-1181
-
-
Bouguen, G.1
Peyrin-Biroulet, L.2
-
120
-
-
42349111818
-
Role of biologics and other therapies in stricturing Crohn's disease: What have we learnt so far?
-
SORRENTINO D. Role of biologics and other therapies in stricturing Crohn's disease: what have we learnt so far? Digestion 2008; 77: 38-47.
-
(2008)
Digestion
, vol.77
, pp. 38-47
-
-
Sorrentino, D.1
-
122
-
-
34249944864
-
Inflammation and the mucosal microcirculation in inflammatory bowel disease: The ebb and flow
-
DANESE S. Inflammation and the mucosal microcirculation in inflammatory bowel disease: the ebb and flow. Curr Opin Gastroenterol 2007; 23: 384-389.
-
(2007)
Curr Opin Gastroenterol
, vol.23
, pp. 384-389
-
-
Danese, S.1
-
123
-
-
53849097306
-
Nonimmune cells in inflammatory bowel disease: From victim to villain
-
DANESE S. Nonimmune cells in inflammatory bowel disease: from victim to villain", Trends Immunol 2008; 29: 555-564.
-
(2008)
Trends Immunol
, vol.29
, pp. 555-564
-
-
Danese, S.1
-
124
-
-
77954179519
-
Anti-adhesion olecule therapy for inflammatory bowel disease
-
GHOSH S, PANACCIONE R. Anti-adhesion olecule therapy for inflammatory bowel disease. Therap Adv Gastroenterol 2010; 3: 239-258.
-
(2010)
Therap Adv Gastroenterol
, vol.3
, pp. 239-258
-
-
Ghosh, S.1
Panaccione, R.2
-
125
-
-
79953873761
-
Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: Translating preclinical data into new drug therapies
-
KOBOZIEV I, KARLSSON F, ZHANG S, GRISHAM MB. Pharmacological intervention studies using mouse models of the inflammatory bowel diseases: translating preclinical data into new drug therapies. Inflamm Bowel Dis 2011; 17: 1229-1245.
-
(2011)
Inflamm Bowel Dis
, vol.17
, pp. 1229-1245
-
-
Koboziev, I.1
Karlsson, F.2
Zhang, S.3
Grisham, M.B.4
-
126
-
-
0027531528
-
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
-
KULKARNI AB, HUH CG, BECKER D, GEISER A, LYGHT M, FLANDERS KC, ROBERTS AB, SPORN MB, WARD JM, KARLSSON S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993; 90: 770-774.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 770-774
-
-
Kulkarni, A.B.1
Huh, C.G.2
Becker, D.3
Geiser, A.4
Lyght, M.5
Flanders, K.C.6
Roberts, A.B.7
Sporn, M.B.8
Ward, J.M.9
Karlsson, S.10
-
127
-
-
0032565859
-
Smad2 role in mesoderm formation, left-right patterning and craniofacial development
-
NOMURA M, LI E. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 1998; 393: 786-790.
-
(1998)
Nature
, vol.393
, pp. 786-790
-
-
Nomura, M.1
Li, E.2
-
128
-
-
0032584068
-
The tumor suppressor Smad4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
-
YANG X, LI C, HU X, DENG C. The tumor suppressor Smad4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci USA 1998; 95: 3667-3672.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3667-3672
-
-
Yang, X.1
Li, C.2
Hu, X.3
Deng, C.4
-
129
-
-
0033104503
-
Targeted disruption of Smad3 results in impaired mucosal immunity and diminished T cell responsiveness to TGFbeta
-
YANG X, LETTERIO JJ, LECHLEIDER RJ, CHEN L, HAYMAN R, GU H, ROBERTS AB, DENG C. Targeted disruption of Smad3 results in impaired mucosal immunity and diminished T cell responsiveness to TGFbeta. EMBO J 1999; 18: 1280-1291.
-
(1999)
EMBO J
, vol.18
, pp. 1280-1291
-
-
Yang, X.1
Letterio, J.J.2
Lechleider, R.J.3
Chen, L.4
Hayman, R.5
Gu, H.6
Roberts, A.B.7
Deng, C.8
-
130
-
-
0032934979
-
Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
-
DATTO MB, FREDERICK JP, PAN L, BORTON AJ, ZHUANG Y, WANG XF. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999; 19:2 495-2504.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.2
, pp. 495-2504
-
-
Datto, M.B.1
Frederick, J.P.2
Pan, L.3
Borton, A.J.4
Zhuang, Y.5
Wang, X.F.6
-
131
-
-
0032544448
-
Smad3 mutant mice develop metastatic colorectal cancer
-
ZHU Y, RICHARDSON JA, PARADA LF, GRAFF JM. Smad3 mutant mice develop metastatic colorectal cancer. Cell 1998; 94: 703-714.
-
(1998)
Cell
, vol.94
, pp. 703-714
-
-
Zhu, Y.1
Richardson, J.A.2
Parada, L.F.3
Graff, J.M.4
-
132
-
-
79960364782
-
Exploring anti-TGF-β therapies in cancer and fibrosis
-
HAWINKELS LJ, TEN DIJKE P. Exploring anti-TGF-β therapies in cancer and fibrosis. Growth Factors 2011; 29: 140-152.
-
(2011)
Growth Factors
, vol.29
, pp. 140-152
-
-
Hawinkels, L.J.1
Ten Dijke, P.2
-
133
-
-
56249141146
-
Antitransforming growth factor-beta therapy in fibrosis: Recent progress and implications for systemic sclerosis
-
VARGA J, PASCHE B. Antitransforming growth factor-beta therapy in fibrosis: recent progress and implications for systemic sclerosis. Curr Opin Rheumatol 2008; 20: 720-728.
-
(2008)
Curr Opin Rheumatol
, vol.20
, pp. 720-728
-
-
Varga, J.1
Pasche, B.2
-
134
-
-
33847009161
-
Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse
-
HAHM K, LUKASHEV ME, LUO Y, YANG WJ, DOLINSKI BM, WEINREB PH, SIMON KJ, CHUN WANG L, LEONE DR, LOBB RR, MCCRANN DJ, ALLAIRE NE, HORAN GS, FOGO A, KALLURI R, SHIELD CF 3RD, SHEPPARD D, GARDNER HA, VIOLETTE SM. Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol 2007; 170: 110-125.
-
(2007)
Am J Pathol
, vol.170
, pp. 110-125
-
-
Hahm, K.1
Lukashev, M.E.2
Luo, Y.3
Yang, W.J.4
Dolinski, B.M.5
Weinreb, P.H.6
Simon, K.J.7
Chun Wang, L.8
Leone, D.R.9
Lobb, R.R.10
McCrann, D.J.11
Allaire, N.E.12
Horan, G.S.13
Fogo, A.14
Kalluri, R.15
Shield III, C.F.16
Sheppard, D.17
Gardner, H.A.18
Violette, S.M.19
-
135
-
-
38049002642
-
Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation
-
HORAN GS, WOOD S, ONA V, LI DJ, LUKASHEV ME, WEINREB PH, SIMON KJ, HAHM K, ALLAIRE NE, RINALDI NJ, GOYAL J, FEGHALI-BOSTWICK CA, MATTESON EL, O'HARA C, LAFYATIS R, DAVIS GS, HUANG X, SHEPPARD D, VIOLETTE SM. Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med 2008; 177: 56-65.
-
(2008)
Am J Respir Crit Care Med
, vol.177
, pp. 56-65
-
-
Horan, G.S.1
Wood, S.2
Ona, V.3
Li, D.J.4
Lukashev, M.E.5
Weinreb, P.H.6
Simon, K.J.7
Hahm, K.8
Allaire, N.E.9
Rinaldi, N.J.10
Goyal, J.11
Feghali-Bostwick, C.A.12
Matteson, E.L.13
O'hara, C.14
Lafyatis, R.15
Davis, G.S.16
Huang, X.17
Sheppard, D.18
Violette, S.M.19
-
136
-
-
78650189268
-
The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis
-
SULLIVAN BP, WEINREB PH, VIOLETTE SM, LUYENDYK JP. The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis. Am J Pathol. 2010; 177: 2837-2849.
-
(2010)
Am J Pathol.
, vol.177
, pp. 2837-2849
-
-
Sullivan, B.P.1
Weinreb, P.H.2
Violette, S.M.3
Luyendyk, J.P.4
-
137
-
-
84855259695
-
Blocking TGFβ via inhibition of the αvβ6 integrin: A possible therapy for systemic sclerosis interstitial lung disease
-
KATSUMOTO TR, VIOLETTE SM, SHEPPARD D. Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. Int J Rheumatol 2011; 2011: 208-219.
-
(2011)
Int J Rheumatol
, vol.2011
, pp. 208-219
-
-
Katsumoto, T.R.1
Violette, S.M.2
Sheppard, D.3
-
138
-
-
78651099581
-
Hepatocyte growth factor in lung repair and pulmonary fibrosis
-
PANGANIBAN RA, DAY RM. Hepatocyte growth factor in lung repair and pulmonary fibrosis. Acta Pharmacol Sin 2011; 32: 12-20
-
(2011)
Acta Pharmacol Sin
, vol.32
, pp. 12-20
-
-
Panganiban, R.A.1
Day, R.M.2
-
139
-
-
33746151631
-
Hepatocyte growth factor: New arsenal in the fights against renal fibrosis?
-
LIU Y, YANG J. Hepatocyte growth factor: new arsenal in the fights against renal fibrosis? Kidney Int 2006; 70: 238-240.
-
(2006)
Kidney Int
, vol.70
, pp. 238-240
-
-
Liu, Y.1
Yang, J.2
-
140
-
-
69149109088
-
BMP-7 as antagonist of organ fibrosis
-
WEISKIRCHEN R, MEURER SK, GRESSNER OA, HERRMANN J, BORKHAM-KAMPHORST E, GRESSNER AM. BMP-7 as antagonist of organ fibrosis. Front Biosci 2009; 14: 4992-5012.
-
(2009)
Front Biosci
, vol.14
, pp. 4992-5012
-
-
Weiskirchen, R.1
Meurer, S.K.2
Gressner, O.A.3
Herrmann, J.4
Borkham-Kamphorst, E.5
Gressner, A.M.6
-
143
-
-
69949156974
-
Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis
-
DISTLER JH, DISTLER O. Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis. Rheumatology 2008; 47(Suppl 5): v10-1.
-
(2008)
Rheumatology
, vol.47
, Issue.SUPPL. 5
-
-
Distler, J.H.1
Distler, O.2
-
144
-
-
79551573507
-
Imatinib and the treatment of fibrosis: Recent trials and tribulations
-
GORDON J, SPIERA R. Imatinib and the treatment of fibrosis: recent trials and tribulations. Curr Rheumatol Rep 2011; 13: 51-58.
-
(2011)
Curr Rheumatol Rep
, vol.13
, pp. 51-58
-
-
Gordon, J.1
Spiera, R.2
-
145
-
-
70849136597
-
Connective tissue growth factor-(CTGF, CCN2) - A marker, mediator and therapeutic target for renal fibrosis
-
PHANISH MK, WINN SK, DOCKRELL ME. Connective tissue growth factor-(CTGF, CCN2)-a marker, mediator and therapeutic target for renal fibrosis. Nephron Exp Nephrol 2010; 114: e83-92.
-
(2010)
Nephron Exp Nephrol
, vol.114
-
-
Phanish, M.K.1
Winn, S.K.2
Dockrell, M.E.3
-
146
-
-
84860349542
-
Regulation of hepatic stellate cells by connective tissue growth factor
-
HUANG G, BRIGSTOCK DR. Regulation of hepatic stellate cells by connective tissue growth factor. Front Biosci 2012; 17: 2495-2507.
-
(2012)
Front Biosci
, vol.17
, pp. 2495-2507
-
-
Huang, G.1
Brigstock, D.R.2
-
147
-
-
57249094020
-
IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis
-
FICHTNER-FEIGL S, YOUNG CA, KITANI A, GEISSLER EK, SCHLITT HJ, STROBER W. IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 2008; 135: 2003-2013.
-
(2008)
Gastroenterology
, vol.135
, pp. 2003-2013
-
-
Fichtner-Feigl, S.1
Young, C.A.2
Kitani, A.3
Geissler, E.K.4
Schlitt, H.J.5
Strober, W.6
-
148
-
-
34247586091
-
Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis
-
FICHTNER-FEIGL S, FUSS IJ, YOUNG CA, WATANABE T, GEISSLER EK, SCHLITT HJ, KITANI A, STROBER W. Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J Immunol 2007; 178: 5859-5870.
-
(2007)
J Immunol
, vol.178
, pp. 5859-5870
-
-
Fichtner-Feigl, S.1
Fuss, I.J.2
Young, C.A.3
Watanabe, T.4
Geissler, E.K.5
Schlitt, H.J.6
Kitani, A.7
Strober, W.8
-
149
-
-
54549111991
-
Oxidative and nitrosative stress and fibrogenic response
-
URTASUN R, CONDE DE LA ROSA L, NIETO N. Oxidative and nitrosative stress and fibrogenic response. Clin Liver Dis 2008; 12: 769-790.
-
(2008)
Clin Liver Dis
, vol.12
, pp. 769-790
-
-
Urtasun, R.1
Conde De La Rosa, L.2
Nieto, N.3
-
150
-
-
0037361993
-
In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats
-
SERRANO-MOLLAR A, CLOSA D, PRATS N, BLESA S, MARTINEZ-LOSA M, CORTIJO J, ESTRELA JM, MORCILLO EJ, BULBENA O. In vivo antioxidant treatment protects against bleomycin-induced lung damage in rats. Br J Pharmacol 2003, 138: 1037-1048.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1037-1048
-
-
Serrano-Mollar, A.1
Closa, D.2
Prats, N.3
Blesa, S.4
Martinez-Losa, M.5
Cortijo, J.6
Estrela, J.M.7
Morcillo, E.J.8
Bulbena, O.9
-
151
-
-
0035145392
-
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells
-
SVEGLIATI-BARONI G, SACCOMANNO S, VAN GOOR H, JANSEN P, BENEDETTI A, MOSHAGE H. Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells. Liver 2001; 21: 1-12.
-
(2001)
Liver
, vol.21
, pp. 1-12
-
-
Svegliati-Baroni, G.1
Saccomanno, S.2
Van Goor, H.3
Jansen, P.4
Benedetti, A.5
Moshage, H.6
-
152
-
-
0029115715
-
Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity
-
RACHMILEWITZ D, KARMELI F, OKON E, BURSZTYN M. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995; 37: 247-255.
-
(1995)
Gut
, vol.37
, pp. 247-255
-
-
Rachmilewitz, D.1
Karmeli, F.2
Okon, E.3
Bursztyn, M.4
-
153
-
-
78751616780
-
Mammalian target of rapamycin (mTOR) inhibitors: Potential uses and a review of haematological adverse effects
-
SOFRONIADOU S, GOLDSMITH D. Mammalian target of rapamycin (mTOR) inhibitors: potential uses and a review of haematological adverse effects. Drug Saf 2011; 34: 97-115.
-
(2011)
Drug Saf
, vol.34
, pp. 97-115
-
-
Sofroniadou, S.1
Goldsmith, D.2
-
154
-
-
34247121519
-
MTOR as a potential therapeutic target for treatment of keloids and excessive scars
-
ONG CT, KHOO YT, MUKHOPADHYAY A, DO DV, LIM IJ, AALAMI O, PHAN TT. mTOR as a potential therapeutic target for treatment of keloids and excessive scars. Exp Dermatol 2007; 16: 394-404.
-
(2007)
Exp Dermatol
, vol.16
, pp. 394-404
-
-
Ong, C.T.1
Khoo, Y.T.2
Mukhopadhyay, A.3
Do, D.V.4
Lim, I.J.5
Aalami, O.6
Phan, T.T.7
-
155
-
-
67649950978
-
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis
-
KORFHAGEN TR, LE CRAS TD, DAVIDSON CR, SCHMIDT SM, IKEGAMI M, WHITSETT JA, HARDIE WD. Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 2009; 41: 562-572.
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 562-572
-
-
Korfhagen, T.R.1
Le Cras, T.D.2
Davidson, C.R.3
Schmidt, S.M.4
Ikegami, M.5
Whitsett, J.A.6
Hardie, W.D.7
-
156
-
-
78349313076
-
The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation
-
GEISSLER EK, SCHLITT HJ. The potential benefits of rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation. Kidney Int 2010; 78: 1075-1079.
-
(2010)
Kidney Int
, vol.78
, pp. 1075-1079
-
-
Geissler, E.K.1
Schlitt, H.J.2
-
157
-
-
79960440859
-
Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclospor ine A and tacrolimus in experimental liver fibrosis
-
PATSENKER E, SCHNEIDER V, LEDERMANN M, SAEGESSER H, DORN C, HELLERBRAND C, STICKEL F. Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclospor ine A and tacrolimus in experimental liver fibrosis. J Hepatol 2011; 55: 388-398.
-
(2011)
J Hepatol
, vol.55
, pp. 388-398
-
-
Patsenker, E.1
Schneider, V.2
Ledermann, M.3
Saegesser, H.4
Dorn, C.5
Hellerbrand, C.6
Stickel, F.7
-
158
-
-
33750433893
-
Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
-
NEEF M, LEDERMANN M, SAEGESSER H, SCHNEIDER V, REICHEN J. Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis. J Hepatol 2006; 45: 786-796.
-
(2006)
J Hepatol
, vol.45
, pp. 786-796
-
-
Neef, M.1
Ledermann, M.2
Saegesser, H.3
Schneider, V.4
Reichen, J.5
-
159
-
-
50249111131
-
Case report Use of sirolimus (rapamycin) to treat refractory Crohn's disease
-
MASSEY DC, BREDIN F, PARKES M. Case report Use of sirolimus (rapamycin) to treat refractory Crohn's disease Gut 2008; 57: 1294-1296.
-
(2008)
Gut
, vol.57
, pp. 1294-1296
-
-
Massey, D.C.1
Bredin, F.2
Parkes, M.3
-
160
-
-
46049115921
-
Everolimus for refractory Crohn's disease: A case report
-
DUMORTIER J, LAPALUS MG, GUILLAUD O, PONCET G, GAGNIEU MC, PARTENSKY C, SCOAZEC JY. Everolimus for refractory Crohn's disease: a case report. Inflamm Bowel Dis 2008; 14: 874-877.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 874-877
-
-
Dumortier, J.1
Lapalus, M.G.2
Guillaud, O.3
Poncet, G.4
Gagnieu, M.C.5
Partensky6
-
161
-
-
50649125243
-
A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease
-
REINISCH W, PANÉS J, LÉMANN M, SCHREIBER S, FEAGAN B, SCHMIDT S, STURNIOLO GC, MIKHAILOVA T, ALEXEEVA O, SANNA L, HAAS T, KOROM S, MAYER H. A multicenter, randomized, double-blind trial of everolimus versus azathioprine and placebo to maintain steroid-induced remission in patients with moderate-to-severe active Crohn's disease. Am J Gastroenterol 2008; 103: 2284-2292.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 2284-2292
-
-
Reinisch, W.1
Panés, J.2
Lémann, M.3
Schreiber, S.4
Feagan, B.5
Schmidt, S.6
Sturniolo, G.C.7
Mikhailova, T.8
Alexeeva, O.9
Sanna, L.10
Haas, T.11
Korom, S.12
Mayer, H.13
-
162
-
-
79751491258
-
Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice
-
NAN YM, HAN F, KONG LB, ZHAO SX, WANG RQ, WU WJ, YU J. Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice. Scand J Gastroenterol 2011; 46: 358-369.
-
(2011)
Scand J Gastroenterol
, vol.46
, pp. 358-369
-
-
Nan, Y.M.1
Han, F.2
Kong, L.B.3
Zhao, S.X.4
Wang, R.Q.5
Wu, W.J.6
Yu, J.7
-
163
-
-
69449094871
-
Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis
-
KAPOOR M, MCCANN M, LIU S, HUH K, DENTON CP, ABRAHAM DJ, LEASK A. Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. Arthritis Rheum 2009; 60: 2822-2829.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 2822-2829
-
-
Kapoor, M.1
McCann, M.2
Liu, S.3
Huh, K.4
Denton, C.P.5
Abraham, D.J.6
Leask, A.7
-
164
-
-
78349281192
-
PPARγ downregulation by TGFβ in fibroblast and impaired expression and function in systemic sclerosis: A novel mechanism for progressive fibrogenesis
-
WEI J, GHOSH AK, SARGENT JL, KOMURA K, WU M, HUANG QQ, JAIN M, WHITFIELD ML, FEGHALI-BOSTWICK C, VARGA J. PPARγ downregulation by TGFβ in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis. PLoS One 2010; 5: e13778.
-
(2010)
PLoS One
, vol.5
-
-
Wei, J.1
Ghosh, A.K.2
Sargent, J.L.3
Komura, K.4
Wu, M.5
Huang, Q.Q.6
Jain, M.7
Whitfield, M.L.8
Feghali-Bostwick, C.9
Varga, J.10
-
165
-
-
59649085854
-
Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma
-
WU M, MELICHIAN DS, CHANG E, WARNER-BLANKENSHIP M, GHOSH AK, VARGA J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma. Am J Pathol 2009; 174: 519-533.
-
(2009)
Am J Pathol
, vol.174
, pp. 519-533
-
-
Wu, M.1
Melichian, D.S.2
Chang, E.3
Warner-Blankenship, M.4
Ghosh, A.K.5
Varga, J.6
-
166
-
-
58149127646
-
PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta
-
KAWAI T, MASAKI T, DOI S, ARAKAWA T, YOKOYAMA Y, DOI T, KOHNO N, YORIOKA N. PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta. Lab Invest 2009; 89: 47-58.
-
(2009)
Lab Invest
, vol.89
, pp. 47-58
-
-
Kawai, T.1
Masaki, T.2
Doi, S.3
Arakawa, T.4
Yokoyama, Y.5
Doi, T.6
Kohno, N.7
Yorioka, N.8
-
167
-
-
64449087454
-
Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand,suppresses bleomycin-induced acute lung injury and fibrosis
-
AOKI Y, MAENO T, AOYAGI K, UENO M, AOKI F, AOKI N, NAKAGAWA J, SANDO Y, SHIMIZU Y, SUGA T, ARAI M, KURABAYASHI M. Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand,suppresses bleomycin-induced acute lung injury and fibrosis. Respiration 2009; 77: 311-319.
-
(2009)
Respiration
, vol.77
, pp. 311-319
-
-
Aoki, Y.1
Maeno, T.2
Aoyagi, K.3
Ueno, M.4
Aoki, F.5
Aoki, N.6
Nakagawa, J.7
Sando, Y.8
Shimizu, Y.9
Suga, T.10
Arai, M.11
Kurabayashi, M.12
-
168
-
-
78651308524
-
Effectiveness of the PPARγ agonist, GW570, in liver fibrosis
-
YANG L, STIMPSON SA, CHEN L, WALLACE HARRINGTON W, ROCKEY DC. Effectiveness of the PPARγ agonist, GW570, in liver fibrosis. Inflamm Res 2010; 59: 1061-1071.
-
(2010)
Inflamm Res
, vol.59
, pp. 1061-1071
-
-
Yang, L.1
Stimpson, S.A.2
Chen, L.3
Wallace Harrington, W.4
Rockey, D.C.5
-
169
-
-
33846180682
-
Matrix metalloproteinases in inflammatory bowel disease: Boon or a bane?
-
RAVI A, GARG P, SITARAMAN SV. Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Inflamm Bowel Dis 2007; 13: 97-107.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 97-107
-
-
Ravi, A.1
Garg, P.2
Sitaraman, S.V.3
-
170
-
-
72849130196
-
Targeting matrix metalloproteinases in inflammatory conditions
-
CLUTTERBUCK AL, ASPLIN KE, HARRIS P, ALLAWAY D, MOBASHERI A. Targeting matrix metalloproteinases in inflammatory conditions. Curr Drug Targets 2009; 10: 1245-1254.
-
(2009)
Curr Drug Targets
, vol.10
, pp. 1245-1254
-
-
Clutterbuck, A.L.1
Asplin, K.E.2
Harris, P.3
Allaway, D.4
Mobasheri, A.5
-
171
-
-
77249121584
-
Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts
-
SHYU KG, WANG BW, CHEN WJ, KUAN P, HUNG CR. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Eur J Heart Fail 2010; 12: 219-226.
-
(2010)
Eur J Heart Fail
, vol.12
, pp. 219-226
-
-
Shyu, K.G.1
Wang, B.W.2
Chen, W.J.3
Kuan, P.4
Hung, C.R.5
-
172
-
-
65249154053
-
Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts
-
BURKE JP, WATSON RW, MURPHY M, DOCHERTY NG, COFFEY JC, O'CONNELL PR. Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts. Br J Surg 2009; 96: 541-551.
-
(2009)
Br J Surg
, vol.96
, pp. 541-551
-
-
Burke, J.P.1
Watson, R.W.2
Murphy, M.3
Docherty, N.G.4
Coffey, J.C.5
O'connell, P.R.6
-
173
-
-
84856706321
-
Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis
-
ABE Y, MURANO M, MURANO N, MORITA E, INOUE T, KAWAKAMI K, ISHIDA K, KURAMOTO T, KAKIMOTO K, OKADA T, NARABAYASHI K, UMEGAKI E, HIGUCHI K. Simvastatin attenuates intestinal fibrosis independent of the anti-inflammatory effect by promoting fibroblast/myofibroblast apoptosis in the regeneration/healing process from TNBS-induced colitis. Dig Dis Sci 2012; 57: 335-344.
-
(2012)
Dig Dis Sci
, vol.57
, pp. 335-344
-
-
Abe, Y.1
Murano, M.2
Murano, N.3
Morita, E.4
Inoue, T.5
Kawakami, K.6
Ishida, K.7
Kuramoto, T.8
Kakimoto, K.9
Okada, T.10
Narabayashi, K.11
Umegaki, E.12
Higuchi, K.13
-
174
-
-
63949084807
-
Lymphatic vessels develop during tubulointerstitial fibrosis
-
SAKAMOTO I, ITO Y, MIZUNO M, SUZUKI Y, SAWAI A, TANAKA A, MARUYAMA S, TAKEI Y, YUZAWA Y, MATSUO S. Lymphatic vessels develop during tubulointerstitial fibrosis. Kidney Int 2009; 75: 828-838.
-
(2009)
Kidney Int
, vol.75
, pp. 828-838
-
-
Sakamoto, I.1
Ito, Y.2
Mizuno, M.3
Suzuki, Y.4
Sawai, A.5
Tanaka, A.6
Maruyama, S.7
Takei, Y.8
Yuzawa, Y.9
Matsuo, S.10
-
175
-
-
79958227886
-
Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'Brothers in arms'
-
DANESE S. Role of the vascular and lymphatic endothelium in the pathogenesis of inflammatory bowel disease: 'brothers in arms'. Gut 2011; 60: 998-1008.
-
(2011)
Gut
, vol.60
, pp. 998-1008
-
-
Danese, S.1
-
176
-
-
58649111743
-
VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis
-
SCALDAFERRI F, VETRANO S, SANS M, ARENA V, STRAFACE G, STIGLIANO E, REPICI A, STURM A, MALESCI A, PANES J, YLA-HERTTUALA S, FIOCCHI C, DANESE S. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis. Gastroenterology 2009; 136: 585-595.
-
(2009)
Gastroenterology
, vol.136
, pp. 585-595
-
-
Scaldaferri, F.1
Vetrano, S.2
Sans, M.3
Arena, V.4
Straface, G.5
Stigliano, E.6
Repici, A.7
Sturm, A.8
Malesci, A.9
Panes, J.10
Yla-Herttuala, S.11
Fiocchi, C.12
Danese, S.13
-
177
-
-
84857682579
-
Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics
-
HERING NA, FROMM M, SCHULZKE JD. Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics. J Physiol 2012; 590: 1035-1044.
-
(2012)
J Physiol
, vol.590
, pp. 1035-1044
-
-
Hering, N.A.1
Fromm, M.2
Schulzke, J.D.3
-
178
-
-
84867027990
-
Mucosal healing in inflammatory bowel diseases: A systematic review
-
NEURATH MF, TRAVIS SP. Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 2012; 61: 1619-1635.
-
(2012)
Gut
, vol.61
, pp. 1619-1635
-
-
Neurath, M.F.1
Travis, S.P.2
-
179
-
-
84870880811
-
The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease
-
HARTMANN P, CHEN WC, SCHNABL B. The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease. Front Physiol 2012; 3: 402.
-
(2012)
Front Physiol
, vol.3
, pp. 402
-
-
Hartmann, P.1
Chen, W.C.2
Schnabl, B.3
-
180
-
-
84856006423
-
Participation of miR-200 in pulmonary fibrosis
-
YANG S, BANERJEE S, DE FREITAS A, SANDERS YY, DING Q, MATALON S, THANNICKAL VJ, ABRAHAM E, LIU G. Participation of miR-200 in pulmonary fibrosis. Am J Pathol 2012; 180: 484-493.
-
(2012)
Am J Pathol
, vol.180
, pp. 484-493
-
-
Yang, S.1
Banerjee, S.2
De Freitas, A.3
Sanders, Y.Y.4
Ding, Q.5
Matalon, S.6
Thannickal, V.J.7
Abraham, E.8
Liu, G.9
-
181
-
-
78751516162
-
MiR-200a Prevents renal fibrogenesis through repression of TGF-β2 expression
-
WANG B, KOH P, WINBANKS C, COUGHLAN MT, MCCLELLAND A, WATSON A, JANDELEIT-DAHM K, BURNS WC, THOMAS MC, COOPER ME, KANTHARIDIS P. miR-200a Prevents renal fibrogenesis through repression of TGF-β2 expression. Diabetes 2011; 60: 280-287.
-
(2011)
Diabetes
, vol.60
, pp. 280-287
-
-
Wang, B.1
Koh, P.2
Winbanks, C.3
Coughlan, M.T.4
McClelland, A.5
Watson, A.6
Jandeleit-Dahm, K.7
Burns, W.C.8
Thomas, M.C.9
Cooper, M.E.10
Kantharidis, P.11
-
182
-
-
84863242402
-
MiR-200b is involved in intestinal fibrosis of Crohn's disease
-
CHEN Y, GE W, XU L, QU C, ZHU M, ZHANG W, XIAO Y. miR-200b is involved in intestinal fibrosis of Crohn's disease. Int J Mol Med 2012; 29: 601-606.
-
(2012)
Int J Mol Med
, vol.29
, pp. 601-606
-
-
Chen, Y.1
Ge, W.2
Xu, L.3
Qu, C.4
Zhu, M.5
Zhang, W.6
Xiao, Y.7
-
183
-
-
83555161689
-
MicroRNAs in inflammatory bowel disease
-
PEKOW JR, KWON JH. MicroRNAs in inflammatory bowel disease. Inflamm Bowel Dis 2012; 18: 187-193.
-
(2012)
Inflamm Bowel Dis
, vol.18
, pp. 187-193
-
-
Pekow, J.R.1
Kwon, J.H.2
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