The role of IL-7 in renal proximal tubule epithelial cells fibrosis

Molecular Immunology

Volumn 50, Issue 1-2, 2012, Pages 74-82

  Hsieh, Pei fang ^a   Liu, Shu Fen ^b   Lee, Tao Chen ^c   Huang, Jau Shyang ^a   Yin, Li Te ^a   Chang, Wen Teng ^a   Chuang, Lea Yea ^b   Guh, Jinn Yuh ^b   Hung, Min Yuan ^a   Yang, Yu Lin ^a  

^a CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

EMT; High glucose; IL 7; Renal fibrosis; Smads

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FIBRONECTIN; GLUCOSE; INTERLEUKIN 7; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ACTINS; BLOTTING, WESTERN; CADHERINS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FIBRONECTINS; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSE; HUMANS; INTERLEUKIN-7; KIDNEY TUBULES, PROXIMAL; MUSCLE, SMOOTH; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

GASTROPODA;

EID: 84862804933     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.12.004     Document Type: Article

References (27)

1. Åsa A., Yang S.-C., Huang M., Zhu L., Kar U.K., Batra R.K., Elashoff D., Strieter R.M., Dubinett S.M., Sharma S. IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer. J. Immunol. 2009, 182:6951-6958.
2. Attisano L., Wrana J.L., et al. Signal transduction by the TGF-beta superfamily. Science 2002, 296:1646-1647.
3. Craven P.A., Studer R.K., Felder J., Phillips S., DeRubertis F.R. Nitric oxide inhibition of transforming growth factor-beta and collagen synthesis in mesangial cells. Diabetes 1997, 46:671-681.
4. Di Paolo S., Gesualdo L., Ranieri E., Grandaliano G., Schena F.P. High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells. Am. J. Pathol. 1996, 149:2095-2106.
5. Dubinett S.M., et al. Down-regulation of macrophage TGF-β messenger RNA expression by interleukin-7. J. Immunol. 1993, 51:6670-6680.
6. Forbes J.M., Fukami K., et al. Diabetic nephropathy: where hemodynamics meets metabolism. Exp. Clin. Endocrinol. Diabetes 2007, 115:69-84.
7. Gambaro G., D'Angelo A., Fabris A., Tosetto E., Anglani F., Lupo A. Crystals, Randall's plaques and renal stones: Do bone and atherosclerosis teach us something?. J Nephrol 2004, 17:774-777.
8. Hewitson T.D., et al. Renal tubulointerstitial fibrosis: common but never simple. Am. J. Physiol. Ren. Physiol. 2009, 296:F1239-F1244.
9. Hoffman B.B., Sharma K., Zhu Y., Ziyadeh, et al. FN: Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration. Kidney Int. 1998, 54:1107-1116.
10. Huang J.S., Chuang L.Y., Guh J.Y., Huang Y.J., Hsu M.S. Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol 2007, 293(4):F1072-F1082.
11. Itoh S., ten Dijke P., et al. Negative regulation of TGF-beta receptor/Smad signal transduction. Curr. Opin. Cell Biol. 2007, 19:176-184.
12. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004, 15(1):1-12.
13. Madeline M., et al. Regulation and consequences of differential gene expression in diabetic kidney disease. Biochem. Soc. Trans. 2008, 36:941-945.
14. Pellegrini M., Calzascia T., Elford A.R., Shahinian A., Lin A.E., Dissanayake D., Dhanji S., Nguyen L.T., Gronsk M.A., Morre M., Assouline B., Lahl K., Sparwasser T., Ohashi P.S., Mak T.W. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat. Med. 2009, 15:528-536. 10.1038/nm.1953.
15. Moustakas A., Souchelnytskyi S., Heldin C.H. Smad regulation in TGFbeta signal transduction. J. Cell Sci. 2001, 114:4359-4369.
16. Murphy M., Godson C., Cannon S., Kato S., Mackenzie H.S., Martin F., Brady H.R., et al. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J. Biol. Chem. 1999, 274:5830-5834.
17. Peinado H., Portillo F., Cano A. Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol. 2004, 48(5-6):365-375.
18. Satriano J., et al. Kidney growth, hypertrophy and the unifying mechanism of diabetic complications. Amino Acids 2007, 33:331-339.
19. Sharma K., Jin Y., Guo J., Ziyadeh F.N., et al. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 1996, 45:522-530.
20. Shi Y., Massague J., et al. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003, 113:685-700.
21. Siska S., Saad S., Tang O., Yong R., McGinn S., Chen X.-M., Pollock C.A. Differential regulation of Snail by hypoxia and hyperglycemia in human proximal tubule cells. Int. J. Biochem. Cell Biol. 2010, 42:1689-1697.
22. Tang J., Nuccie B.L., Ritterman I., Liesveld J.L., Abboud C.N., Ryan D.H., et al. TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. J. Immunol. 1997, 159(1):117-125.
23. Wahab N.A., Harper K., Mason R.M. Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia. Biochem. J. 1996, 316:985-992.
24. Wolf G., Sharma K., Chen Y., Ericksen M., Ziyadeh, et al. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. Kidney Int. 1992, 42:647-656.
25. Wolf G., Ziyadeh, et al. Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron Physiol. 2007, 106:26-31.
26. Yamagishi S., Fukami K., Ueda S., Okuda S. Molecular mechanisms of diabetic nephropathy and its therapeutic intervention. Curr. Drug. Targets 2007, 952-959.
27. Yamanaka O., Saika S., Ikeda K., Miyazaki K., Ohnishi Y., Ooshima A. Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts. Curr. Eye Res. 2006, 31(6):491-499.