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Volumn 6, Issue FEB, 2018, Pages

Exosome-based cell-cell communication in the tumor microenvironment

Author keywords

Cancer; Cell cell communication; Exosomes; Extracellular vesicles (EVs); Tumor microenvironment

Indexed keywords


EID: 85042789357     PISSN: None     EISSN: 2296634X     Source Type: Journal    
DOI: 10.3389/fcell.2018.00018     Document Type: Review
Times cited : (521)

References (219)
  • 1
    • 84896323201 scopus 로고    scopus 로고
    • Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes
    • Abd Elmageed, Z. Y., Yang, Y., Thomas, R., Ranjan, M., Mondal, D., Moroz, K., et al. (2014). Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes. Stem Cells 32, 983-997. doi: 10.1002/stem.1619
    • (2014) Stem Cells , vol.32 , pp. 983-997
    • Abd Elmageed, Z.Y.1    Yang, Y.2    Thomas, R.3    Ranjan, M.4    Mondal, D.5    Moroz, K.6
  • 2
    • 85028623401 scopus 로고    scopus 로고
    • Exosomes isolated from cancer patients' sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells
    • Abdouh, M., Hamam, D., Gao, Z. H., Arena, V., Arena, M., and Arena, G. O. (2017). Exosomes isolated from cancer patients' sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells. J. Exp. Clin. Cancer Res. 36, 113. doi: 10.1186/s13046-017-0587-0
    • (2017) J. Exp. Clin. Cancer Res , vol.36 , pp. 113
    • Abdouh, M.1    Hamam, D.2    Gao, Z.H.3    Arena, V.4    Arena, M.5    Arena, G.O.6
  • 3
    • 24644524011 scopus 로고    scopus 로고
    • Tumor exosomes expressing Fas ligand mediate CD8 + T-cell apoptosis
    • Abusamra, A. J., Zhong, Z., Zheng, X., Li, M., Ichim, T. E., Chin, J. L., et al. (2005). Tumor exosomes expressing Fas ligand mediate CD8 + T-cell apoptosis. Blood Cells Mol. Dis. 35, 169-173. doi: 10.1016/j.bcmd.2005.07.001
    • (2005) Blood Cells Mol. Dis , vol.35 , pp. 169-173
    • Abusamra, A.J.1    Zhong, Z.2    Zheng, X.3    Li, M.4    Ichim, T.E.5    Chin, J.L.6
  • 4
    • 84896408214 scopus 로고    scopus 로고
    • Exosomal HIF1a supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes
    • Aga, M., Bentz, G. L., Raffa, S., Torrisi, M. R., Kondo, S., Wakisaka, N., et al. (2014). Exosomal HIF1a supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes. Oncogene 33, 4613-4622. doi: 10.1038/onc.2014.66
    • (2014) Oncogene , vol.33 , pp. 4613-4622
    • Aga, M.1    Bentz, G.L.2    Raffa, S.3    Torrisi, M.R.4    Kondo, S.5    Wakisaka, N.6
  • 5
    • 62649095692 scopus 로고    scopus 로고
    • Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
    • Al-Nedawi, K., Meehan, B., Kerbel, R. S., Allison, A. C., and Rak, J. (2009). Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc. Natl. Acad. Sci. U.S.A. 106, 3794-3799. doi: 10.1073/pnas.0804543106
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 3794-3799
    • Al-Nedawi, K.1    Meehan, B.2    Kerbel, R.S.3    Allison, A.C.4    Rak, J.5
  • 6
    • 10744229153 scopus 로고    scopus 로고
    • Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells
    • André, F., Chaput, N., Schartz, N. E. C., Flament, C., Aubert, N., Bernard, J., et al. (2004). Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells. J. Immunol. 172, 2126-2136. doi: 10.4049/jimmunol.172.4.2126
    • (2004) J. Immunol , vol.172 , pp. 2126-2136
    • André, F.1    Chaput, N.2    Schartz, N.E.C.3    Flament, C.4    Aubert, N.5    Bernard, J.6
  • 7
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • Andre, F., Schartz, N. E., Movassagh, M., Flament, C., Pautier, P., Morice, P., et al. (2002). Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360, 295-305. doi: 10.1016/S0140-6736(02)09552-1
    • (2002) Lancet , vol.360 , pp. 295-305
    • Andre, F.1    Schartz, N.E.2    Movassagh, M.3    Flament, C.4    Pautier, P.5    Morice, P.6
  • 8
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola, G., Rivoltini, L., Castelli, C., Huber, V., Perego, P., Deho, P., et al. (2002). Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 195, 1303-1316. doi: 10.1084/jem.20011624
    • (2002) J. Exp. Med , vol.195 , pp. 1303-1316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3    Huber, V.4    Perego, P.5    Deho, P.6
  • 9
    • 76549099879 scopus 로고    scopus 로고
    • Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
    • Ashiru, O., Boutet, P., Fernández-Messina, L., Agüera-González, S., Skepper, J. N., Valás-Gómez, M., et al. (2010). Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 70, 481-489. doi: 10.1158/0008-5472.CAN-09-1688
    • (2010) Cancer Res , vol.70 , pp. 481-489
    • Ashiru, O.1    Boutet, P.2    Fernández-Messina, L.3    Agüera-González, S.4    Skepper, J.N.5    Valás-Gómez, M.6
  • 10
    • 85030723865 scopus 로고    scopus 로고
    • Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior
    • Bandari, S. K., Purushothaman, A., Ramani, V. C., Brinkley, G. J., Chandrashekar, D. S., Varambally, S., et al. (2018). Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior. Matrix Biol. 65, 104-118. doi: 10.1016/j.matbio.2017.09.001
    • (2018) Matrix Biol , vol.65 , pp. 104-118
    • Bandari, S.K.1    Purushothaman, A.2    Ramani, V.C.3    Brinkley, G.J.4    Chandrashekar, D.S.5    Varambally, S.6
  • 11
    • 85003945007 scopus 로고    scopus 로고
    • Extracellular vesicles in cancer: cell-to-cell mediators of metastasis
    • Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., and Lyden, D. (2016). Extracellular vesicles in cancer: cell-to-cell mediators of metastasis. Cancer Cell 30, 836-848. doi: 10.1016/j.ccell.2016.10.009
    • (2016) Cancer Cell , vol.30 , pp. 836-848
    • Becker, A.1    Thakur, B.K.2    Weiss, J.M.3    Kim, H.S.4    Peinado, H.5    Lyden, D.6
  • 12
    • 84962861045 scopus 로고    scopus 로고
    • Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer
    • Berchem, G., Noman, M. Z., Bosseler, M., Baconnais, S., Le, E., Nanbakhsh, A., et al. (2016). Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer. Oncoimmunology 5, 1-13. doi: 10.1080/2162402X.2015.1062968
    • (2016) Oncoimmunology , vol.5 , pp. 1-13
    • Berchem, G.1    Noman, M.Z.2    Bosseler, M.3    Baconnais, S.4    Le, E.5    Nanbakhsh, A.6
  • 13
    • 84962844515 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC
    • Besse, B., Charrier, M. L., Lapierre, V. r, Dansin, E., Lantz, O., Planchard, D., et al. (2016). Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. Oncoimmunology 5:e1071008. doi: 10.1080/2162402X.2015.1071008
    • (2016) Oncoimmunology , vol.5
    • Besse, B.1    Charrier, M.L.2    Lapierre, V.R.3    Dansin, E.4    Lantz, O.5    Planchard, D.6
  • 14
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer?. A proposed role of the microenvironment in restraining cancer progression
    • Bissell, M. J., and Hines, W. C. (2011). Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat. Med. 17, 320-329. doi: 10.1038/nm.2328
    • (2011) Nat. Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 15
    • 0036533633 scopus 로고    scopus 로고
    • TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex
    • Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., et al. (2002). TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J. Immunol. 168, 3235-3241. doi: 10.4049/jimmunol.168.7.3235
    • (2002) J. Immunol , vol.168 , pp. 3235-3241
    • Blanchard, N.1    Lankar, D.2    Faure, F.3    Regnault, A.4    Dumont, C.5    Raposo, G.6
  • 16
    • 84867120348 scopus 로고    scopus 로고
    • Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression
    • Bobrie, A., Krumeich, S., Reyal, F., Recchi, C., Moita, L. F., Seabra, M. C., et al. (2012). Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 72, 4920-4930. doi: 10.1158/0008-5472.CAN-12-0925
    • (2012) Cancer Res , vol.72 , pp. 4920-4930
    • Bobrie, A.1    Krumeich, S.2    Reyal, F.3    Recchi, C.4    Moita, L.F.5    Seabra, M.C.6
  • 17
    • 84908275360 scopus 로고    scopus 로고
    • Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
    • Boelens, M. C., Wu, T. J., Nabet, B. Y., Xu, B., Qiu, Y., Yoon, T., et al. (2014). Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways. Cell 159, 499-513. doi: 10.1016/j.cell.2014.09.051
    • (2014) Cell , vol.159 , pp. 499-513
    • Boelens, M.C.1    Wu, T.J.2    Nabet, B.Y.3    Xu, B.4    Qiu, Y.5    Yoon, T.6
  • 18
    • 78649325530 scopus 로고    scopus 로고
    • MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis
    • Buschow, S. I., van Balkom, B. W., Aalberts, M., Heck, A. J., Wauben, M., and Stoorvogel, W. (2010). MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88, 851-856. doi: 10.1038/icb.2010.64
    • (2010) Immunol. Cell Biol , vol.88 , pp. 851-856
    • Buschow, S.I.1    van Balkom, B.W.2    Aalberts, M.3    Heck, A.J.4    Wauben, M.5    Stoorvogel, W.6
  • 19
    • 85023780338 scopus 로고    scopus 로고
    • Exosome-derived miR-25-3p and miR-92a-3p stimulate liposarcoma progression
    • Casadei, L., Calore, F., Creighton, C. J., Guescini, M., Batte, K., Iwenofu, O. H., et al. (2017). Exosome-derived miR-25-3p and miR-92a-3p stimulate liposarcoma progression. Cancer Res. 77, 3846-3856. doi: 10.1158/0008-5472.CAN-16-2984
    • (2017) Cancer Res , vol.77 , pp. 3846-3856
    • Casadei, L.1    Calore, F.2    Creighton, C.J.3    Guescini, M.4    Batte, K.5    Iwenofu, O.H.6
  • 22
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mause and human myeloid-derived suppressor cells
    • Chalmin, F., Ladoire, S., Mignot, G., Vincent, J., Bruchard, M., Boireau, W., et al. (2010). Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mause and human myeloid-derived suppressor cells. J. Clin. Invest. 120, 457-471. doi: 10.1172/JCI40483
    • (2010) J. Clin. Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5    Boireau, W.6
  • 23
    • 0006978515 scopus 로고
    • The biological significance of the thromboplastic protein of blood
    • Chargaff, E., and West, R. (1946). The biological significance of the thromboplastic protein of blood. J. Biol. Chem. 166, 189-197
    • (1946) J. Biol. Chem , vol.166 , pp. 189-197
    • Chargaff, E.1    West, R.2
  • 24
    • 85004011298 scopus 로고    scopus 로고
    • NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis
    • Chen, C., Luo, F., Liu, X., Lu, L., Xu, H., and Yang, Q. (2016). NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis. Cancer Lett. 388, 21-33. doi: 10.1016/j.canlet.2016.11.027
    • (2016) Cancer Lett , vol.388 , pp. 21-33
    • Chen, C.1    Luo, F.2    Liu, X.3    Lu, L.4    Xu, H.5    Yang, Q.6
  • 25
    • 33745362875 scopus 로고    scopus 로고
    • Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells
    • Chen, W., Wang, J., Shao, C., Liu, S., Yu, Y., Wang, Q., et al. (2006). Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur. J. Immunol. 36, 1598-1607. doi: 10.1002/eji.200535501
    • (2006) Eur. J. Immunol , vol.36 , pp. 1598-1607
    • Chen, W.1    Wang, J.2    Shao, C.3    Liu, S.4    Yu, Y.5    Wang, Q.6
  • 26
    • 84922392532 scopus 로고    scopus 로고
    • Exosomes from docetaxel-resistant breast cancer cells alter chemosensitivity by delivering microRNAs
    • Chen, W. X., Cai, Y. Q., Lv, M. M., Chen, L., Zhong, S. L., Ma, T. F., et al. (2014a). Exosomes from docetaxel-resistant breast cancer cells alter chemosensitivity by delivering microRNAs. Tumour Biol. 35, 9649-9659. doi: 10.1007/s13277-014-2242-0
    • (2014) Tumour Biol , vol.35 , pp. 9649-9659
    • Chen, W.X.1    Cai, Y.Q.2    Lv, M.M.3    Chen, L.4    Zhong, S.L.5    Ma, T.F.6
  • 27
    • 84930172395 scopus 로고    scopus 로고
    • Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs
    • Chen, W. X., Liu, X. M., Lv, M. M., Chen, L., Zhao, J. H., Zhong, S. L., et al. (2014b). Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs. PLoS ONE 9:e95240. doi: 10.1371/journal.pone.0095240
    • (2014) PLoS ONE , vol.9
    • Chen, W.X.1    Liu, X.M.2    Lv, M.M.3    Chen, L.4    Zhao, J.H.5    Zhong, S.L.6
  • 28
    • 85017344838 scopus 로고    scopus 로고
    • Aberrant low expression of p85a in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b
    • Chen, Y., Zeng, C., Zhan, Y., Wang, H., Jiang, X., and Li, W. (2017). Aberrant low expression of p85a in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b. Oncogene 36, 4692-4705. doi: 10.1038/onc.2017.100
    • (2017) Oncogene , vol.36 , pp. 4692-4705
    • Chen, Y.1    Zeng, C.2    Zhan, Y.3    Wang, H.4    Jiang, X.5    Li, W.6
  • 29
    • 84993982065 scopus 로고    scopus 로고
    • Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages
    • Chen, Z., Yang, L., Cui, Y., Zhou, Y., and Yin, X. (2016). Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages. Oncotarget 7, 27-34. doi: 10.18632/oncotarget.11794
    • (2016) Oncotarget , vol.7 , pp. 27-34
    • Chen, Z.1    Yang, L.2    Cui, Y.3    Zhou, Y.4    Yin, X.5
  • 30
    • 80054717963 scopus 로고    scopus 로고
    • Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts
    • Cho, J. A., Park, H., Lim, E. H., Kim, K. H., Choi, J. S., Lee, J. H., et al. (2011a). Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecol. Oncol. 123, 379-386. doi: 10.1016/j.ygyno.2011.08.005
    • (2011) Gynecol. Oncol , vol.123 , pp. 379-386
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Kim, K.H.4    Choi, J.S.5    Lee, J.H.6
  • 31
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    • Cho, J. A., Park, H., Lim, E. H., and Lee, K. W. (2011b). Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells. Int. J. Oncol. 40, 130-138. doi: 10.3892/ijo.2011.1193
    • (2011) Int. J. Oncol , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 32
    • 84904630086 scopus 로고    scopus 로고
    • Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB
    • Chow, A., Zhou, W., Liu, L., Fong, M. Y., Champer, J., Haute, D. V., et al. (2014). Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB. Sci. Rep. 4:5750. doi: 10.1038/srep05750
    • (2014) Sci. Rep , vol.4 , pp. 5750
    • Chow, A.1    Zhou, W.2    Liu, L.3    Fong, M.Y.4    Champer, J.5    Haute, D.V.6
  • 33
    • 0035166047 scopus 로고    scopus 로고
    • Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry
    • Clayton, A., Court, J., Navabi, H., Adams, M., Mason, M. D., Hobot, J. A., et al. (2001). Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry. J. Immunol. Methods 247, 163-174. doi: 10.1016/S0022-1759(00)00321-5
    • (2001) J. Immunol. Methods , vol.247 , pp. 163-174
    • Clayton, A.1    Court, J.2    Navabi, H.3    Adams, M.4    Mason, M.D.5    Hobot, J.A.6
  • 34
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • Clayton, A., Mitchell, J. P., Court, J., Mason, M. D., and Tabi, Z. (2007). Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res. 67, 7458-7466. doi: 10.1158/0008-5472.CAN-06-3456
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 35
    • 24944495594 scopus 로고    scopus 로고
    • Induction of heat shock proteins in B-cell exosomes
    • Clayton, A., Turkes, A., Navabi, H., Mason, M. D., and Tabi, Z. (2005). Induction of heat shock proteins in B-cell exosomes. J. Cell Sci. 118, 3631-3638. doi: 10.1242/jcs.02494
    • (2005) J. Cell Sci , vol.118 , pp. 3631-3638
    • Clayton, A.1    Turkes, A.2    Navabi, H.3    Mason, M.D.4    Tabi, Z.5
  • 37
    • 84870911785 scopus 로고    scopus 로고
    • Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes
    • Corcoran, C., Rani, S., O'Brien, K., O'Neill, A., Prencipe, M., Sheikh, R., et al. (2012). Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes. PLoS ONE 7:e50999. doi: 10.1371/journal.pone.0050999
    • (2012) PLoS ONE , vol.7
    • Corcoran, C.1    Rani, S.2    O'Brien, K.3    O'Neill, A.4    Prencipe, M.5    Sheikh, R.6
  • 38
    • 84930170395 scopus 로고    scopus 로고
    • Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
    • Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., et al. (2015). Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat. Cell Biol. 17, 816-826. doi: 10.1038/ncb3169
    • (2015) Nat. Cell Biol , vol.17 , pp. 816-826
    • Costa-Silva, B.1    Aiello, N.M.2    Ocean, A.J.3    Singh, S.4    Zhang, H.5    Thakur, B.K.6
  • 39
    • 85009809717 scopus 로고    scopus 로고
    • Functions of cancer-derived extracellular vesicles in immunosuppression
    • Czernek, L., and Düchler, M. (2016). Functions of cancer-derived extracellular vesicles in immunosuppression. Arch. Immunol. Ther. Exp. 65, 311-323. doi: 10.1007/s00005-016-0453-3
    • (2016) Arch. Immunol. Ther. Exp , vol.65 , pp. 311-323
    • Czernek, L.1    Düchler, M.2
  • 40
    • 67349283470 scopus 로고    scopus 로고
    • IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death
    • Czystowska, M., Han, J., Szczepanski, M. J., Szajnik, M., Quadrini, K., Brandwein, H., et al. (2009). IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death. Cell Death Differ. 16, 708-718. doi: 10.1038/cdd.2008.197
    • (2009) Cell Death Differ , vol.16 , pp. 708-718
    • Czystowska, M.1    Han, J.2    Szczepanski, M.J.3    Szajnik, M.4    Quadrini, K.5    Brandwein, H.6
  • 42
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai, S., Wei, D., Wu, Z., Zhou, X., Wei, X., Huang, H., et al. (2008). Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol. Ther. 16, 782-790. doi: 10.1038/mt.2008.1
    • (2008) Mol. Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5    Huang, H.6
  • 43
    • 62449209166 scopus 로고    scopus 로고
    • Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production
    • Dashevsky, O., Varon, D., and Brill, A. (2009). Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production. Int. J. Cancer 124, 1773-1777. doi: 10.1002/ijc.24016
    • (2009) Int. J. Cancer , vol.124 , pp. 1773-1777
    • Dashevsky, O.1    Varon, D.2    Brill, A.3
  • 44
    • 84925270282 scopus 로고    scopus 로고
    • Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells
    • Del Fattore, A., Luciano, R., Saracino, R., Battafarano, G., Rizzo, C., Pascucci, L., et al. (2015). Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells. Expert Opin. Biol. Ther. 15, 495-504. doi: 10.1517/14712598.2015.997706
    • (2015) Expert Opin. Biol. Ther , vol.15 , pp. 495-504
    • Del Fattore, A.1    Luciano, R.2    Saracino, R.3    Battafarano, G.4    Rizzo, C.5    Pascucci, L.6
  • 45
    • 84963877265 scopus 로고    scopus 로고
    • Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity
    • De Veirman, K., Wang, J., Xu, S., Leleu, X., Himpe, E., Maes, K., et al. (2016). Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity. Cancer Lett. 377, 17-24. doi: 10.1016/j.canlet.2016.04.024
    • (2016) Cancer Lett , vol.377 , pp. 17-24
    • De Veirman, K.1    Wang, J.2    Xu, S.3    Leleu, X.4    Himpe, E.5    Maes, K.6
  • 46
    • 85010469830 scopus 로고    scopus 로고
    • Systemic T Cells immunosuppression of glioma stem cell-derived exosomes is mediated by monocytic myeloid-derived suppressor cells
    • Domenis, R., Cesselli, D., Toffoletto, B., Bourkoula, E., Caponnetto, F., Manini, I., et al. (2017). Systemic T Cells immunosuppression of glioma stem cell-derived exosomes is mediated by monocytic myeloid-derived suppressor cells. PLoS ONE 12:e0169932. doi: 10.1371/journal.pone.0169932
    • (2017) PLoS ONE , vol.12
    • Domenis, R.1    Cesselli, D.2    Toffoletto, B.3    Bourkoula, E.4    Caponnetto, F.5    Manini, I.6
  • 47
    • 85015741248 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer
    • Donnarumma, E., Fiore, D., Nappa, M., Roscigno, G., Adamo, A., Iaboni, M., et al. (2017). Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer. Oncotarget 8, 19592-19608. doi: 10.18632/oncotarget.14752
    • (2017) Oncotarget , vol.8 , pp. 19592-19608
    • Donnarumma, E.1    Fiore, D.2    Nappa, M.3    Roscigno, G.4    Adamo, A.5    Iaboni, M.6
  • 49
    • 0020551668 scopus 로고
    • Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells
    • Dvorak, H. F., Van DeWater, L., Bitzer, A. M., Dvorak, A. M., Anderson, D., Harvey, V. S., et al. (1983). Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells. Cancer Res. 43, 4434-4442
    • (1983) Cancer Res , vol.43 , pp. 4434-4442
    • Dvorak, H.F.1    Van DeWater, L.2    Bitzer, A.M.3    Dvorak, A.M.4    Anderson, D.5    Harvey, V.S.6
  • 50
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • Escola, J. M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., and Geuze, H. J. (1998). Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121-20127. doi: 10.1074/jbc.273.32.20121
    • (1998) J. Biol. Chem , vol.273 , pp. 20121-20127
    • Escola, J.M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 51
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial
    • Escudier, B., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., et al. (2005). Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. J. Transl. Med. 3:10. doi: 10.1186/1479-5876-3-10
    • (2005) J. Transl. Med , vol.3 , pp. 10
    • Escudier, B.1    Dorval, T.2    Chaput, N.3    André, F.4    Caby, M.-P.5    Novault, S.6
  • 52
    • 85014336174 scopus 로고    scopus 로고
    • EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
    • EV-TRACK Consortium, Van Deun, J., Mestdagh, P., Agostinis, P., Akay, O., Anand, S., et al. (2017). EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research. Nat. Methods 14, 228-232. doi: 10.1038/nmeth.4185
    • (2017) Nat. Methods , vol.14 , pp. 228-232
    • Van Deun, J.1    Mestdagh, P.2    Agostinis, P.3    Akay, O.4    Anand, S.5
  • 53
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic in fl ammatory response
    • Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., and Santhanam, R. (2012). MicroRNAs bind to Toll-like receptors to induce prometastatic in fl ammatory response. Proc. Natl. Acad. Sci. U.S.A. 109, E2110-E2116. doi: 10.1073/pnas.1209414109
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. E2110-E2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3    Galli, R.4    Gaudio, E.5    Santhanam, R.6
  • 54
    • 13244265094 scopus 로고    scopus 로고
    • Clotting mechanisms and cancer: implications in thrombus formation and tumor progression
    • Falanga, A., Marchetti, M., Vignoli, A., and Balducci, D. (2003). Clotting mechanisms and cancer: implications in thrombus formation and tumor progression. Clin. Adv. Hematol. Oncol. 1, 673-678
    • (2003) Clin. Adv. Hematol. Oncol , vol.1 , pp. 673-678
    • Falanga, A.1    Marchetti, M.2    Vignoli, A.3    Balducci, D.4
  • 55
    • 84878531583 scopus 로고    scopus 로고
    • Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells
    • Fiaschi, T., Giannoni, E., Taddei, M. L., Cirri, P., Marini, A., Pintus, G., et al. (2013). Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells. Cell Cycle 12, 1791-1801. doi: 10.4161/cc.24902
    • (2013) Cell Cycle , vol.12 , pp. 1791-1801
    • Fiaschi, T.1    Giannoni, E.2    Taddei, M.L.3    Cirri, P.4    Marini, A.5    Pintus, G.6
  • 56
    • 85035049477 scopus 로고    scopus 로고
    • Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587
    • Figueroa, J., Phillips, L. M., Shahar, T., Hossain, A., Gumin, J., Kim, H., et al. (2017). Exosomes from glioma-associated mesenchymal stem cells increase the tumorigenicity of glioma stem-like cells via transfer of miR-1587. Cancer Res. 77, 5808-5819. doi: 10.1158/0008-5472.CAN-16-2524
    • (2017) Cancer Res , vol.77 , pp. 5808-5819
    • Figueroa, J.1    Phillips, L.M.2    Shahar, T.3    Hossain, A.4    Gumin, J.5    Kim, H.6
  • 57
    • 84923194150 scopus 로고    scopus 로고
    • Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis
    • Fong, M. Y., Zhou, W., Liu, L., Alontaga, A. Y., Chandra, M., Ashby, J., et al. (2015). Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat. Cell Biol. 17, 183-194. doi: 10.1038/ncb3094
    • (2015) Nat. Cell Biol , vol.17 , pp. 183-194
    • Fong, M.Y.1    Zhou, W.2    Liu, L.3    Alontaga, A.Y.4    Chandra, M.5    Ashby, J.6
  • 58
    • 69249222379 scopus 로고    scopus 로고
    • Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN
    • Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L., et al. (2009). Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. Cancer Cell 16, 183-194. doi: 10.1016/j.ccr.2009.06.017
    • (2009) Cancer Cell , vol.16 , pp. 183-194
    • Fridlender, Z.G.1    Sun, J.2    Kim, S.3    Kapoor, V.4    Cheng, G.5    Ling, L.6
  • 59
    • 84961203978 scopus 로고    scopus 로고
    • The emerging roles of exosomes in tumor-stroma interaction
    • Fu, H., Yang, H., Zhang, X., and Xu, W. (2016). The emerging roles of exosomes in tumor-stroma interaction. J. Cancer Res. Clin. Oncol. 142, 1897-1907. doi: 10.1007/s00432-016-2145-0
    • (2016) J. Cancer Res. Clin. Oncol , vol.142 , pp. 1897-1907
    • Fu, H.1    Yang, H.2    Zhang, X.3    Xu, W.4
  • 60
    • 84897046745 scopus 로고    scopus 로고
    • MiRNA in melanoma-derived exosomes
    • Gajos-Michniewicz, A., Duechler, M., and Czyz, M. (2014). MiRNA in melanoma-derived exosomes. Cancer Lett. 347, 29-37. doi: 10.1016/j.canlet.2014.02.004
    • (2014) Cancer Lett , vol.347 , pp. 29-37
    • Gajos-Michniewicz, A.1    Duechler, M.2    Czyz, M.3
  • 61
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • Gastpar, R., Gehrmann, M., Bausero, M. A., Asea, A., Gross, C., Schroeder, J. A., et al. (2005). Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res. 65, 5238-5247. doi: 10.1158/0008-5472.CAN-04-3804
    • (2005) Cancer Res , vol.65 , pp. 5238-5247
    • Gastpar, R.1    Gehrmann, M.2    Bausero, M.A.3    Asea, A.4    Gross, C.5    Schroeder, J.A.6
  • 62
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., et al. (2012). Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13, 1118-1128. doi: 10.1038/ni.2419
    • (2012) Nat. Immunol , vol.13 , pp. 1118-1128
    • Gautier, E.L.1    Shay, T.2    Miller, J.3    Greter, M.4    Jakubzick, C.5    Ivanov, S.6
  • 63
    • 33746886963 scopus 로고    scopus 로고
    • Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029
    • Gesierich, S., Berezovskiy, I., Ryschich, E., and Zoller, M. (2006). Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029. Cancer Res. 66, 7083-7094. doi: 10.1158/0008-5472.CAN-06-0391
    • (2006) Cancer Res , vol.66 , pp. 7083-7094
    • Gesierich, S.1    Berezovskiy, I.2    Ryschich, E.3    Zoller, M.4
  • 64
    • 77956280130 scopus 로고    scopus 로고
    • Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
    • Giannoni, E., Bianchini, F., Masieri, L., Serni, S., Torre, E., Calorini, L., et al. (2010). Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res. 70, 6945-6956. doi: 10.1158/0008-5472.CAN-10-0785
    • (2010) Cancer Res , vol.70 , pp. 6945-6956
    • Giannoni, E.1    Bianchini, F.2    Masieri, L.3    Serni, S.4    Torre, E.5    Calorini, L.6
  • 65
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S. I., Greten, F. R., and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883-899. doi: 10.1016/j.cell.2010.01.025
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 66
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh, V., Wu, J., Yee, C., and Spies, T. (2002). Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419, 734-738. doi: 10.1038/nature01112
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 67
    • 84991338093 scopus 로고    scopus 로고
    • Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells
    • Gutkin, A., Uziel, O., Beery, E., Nordenberg, J., Pinchasi, M., Goldvaser, H., et al. (2016). Tumor cells derived exosomes contain hTERT mRNA and transform nonmalignant fibroblasts into telomerase positive cells. Oncotarget 7, 59173-59188. doi: 10.18632/oncotarget.10384
    • (2016) Oncotarget , vol.7 , pp. 59173-59188
    • Gutkin, A.1    Uziel, O.2    Beery, E.3    Nordenberg, J.4    Pinchasi, M.5    Goldvaser, H.6
  • 68
    • 85032353718 scopus 로고    scopus 로고
    • Tumor-derived exosomes modulate PD-L1 expression in monocytes
    • Haderk, F., Schulz, R., Iskar, M., Cid, L. L., Worst, T., Willmund, K. V., et al. (2017). Tumor-derived exosomes modulate PD-L1 expression in monocytes. Sci. Immunol. 2:eaah5509. doi: 10.1126/sciimmunol.aah5509
    • (2017) Sci. Immunol , vol.2
    • Haderk, F.1    Schulz, R.2    Iskar, M.3    Cid, L.L.4    Worst, T.5    Willmund, K.V.6
  • 69
    • 85016478970 scopus 로고    scopus 로고
    • Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth
    • Haga, H., Yan, I. K., Takahashi, K., Wood, J., Zubair, A., and Patel, T. (2015). Tumour cell-derived extracellular vesicles interact with mesenchymal stem cells to modulate the microenvironment and enhance cholangiocarcinoma growth. J. Extracell. Vesicles 4:24900. doi: 10.3402/jev.v4.24900
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 24900
    • Haga, H.1    Yan, I.K.2    Takahashi, K.3    Wood, J.4    Zubair, A.5    Patel, T.6
  • 70
    • 84984618961 scopus 로고    scopus 로고
    • Extracellular vesicles from metastatic rat prostate tumors prime the normal prostate tissue to facilitate tumor growth
    • Halin Bergström, S., Hägglöf, C., Thysell, E., Bergh, A., Wikström, P., and Lundholm, M. (2016). Extracellular vesicles from metastatic rat prostate tumors prime the normal prostate tissue to facilitate tumor growth. Sci. Rep. 6:31805. doi: 10.1038/srep31805
    • (2016) Sci. Rep , vol.6 , pp. 31805
    • Halin Bergström, S.1    Hägglöf, C.2    Thysell, E.3    Bergh, A.4    Wikström, P.5    Lundholm, M.6
  • 71
    • 84971499081 scopus 로고    scopus 로고
    • Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients
    • Hamam, D., Abdouh, M., Gao, Z. H., Arena, V., Arena, M., and Arena, G. O. (2016). Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients. J. Exp. Clin. Cancer Res. 35:80. doi: 10.1186/s13046-016-0360-9
    • (2016) J. Exp. Clin. Cancer Res , vol.35 , pp. 80
    • Hamam, D.1    Abdouh, M.2    Gao, Z.H.3    Arena, V.4    Arena, M.5    Arena, G.O.6
  • 72
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674. doi: 10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 73
    • 79952159254 scopus 로고    scopus 로고
    • Thermal-and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma, T., and B cells
    • Hedlund, M., Nagaeva, O., Kargl, D., Baranov, V., and Mincheva-Nilsson, L. (2011). Thermal-and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma, T., and B cells. PLoS ONE 6:e16899. doi: 10.1371/journal.pone.0016899
    • (2011) PLoS ONE , vol.6
    • Hedlund, M.1    Nagaeva, O.2    Kargl, D.3    Baranov, V.4    Mincheva-Nilsson, L.5
  • 74
    • 67651015630 scopus 로고    scopus 로고
    • Platelet microparticles: a potential predictive factor of survival in hormone-refractory prostate cancer patients treated with docetaxel-based chemotherapy
    • Helley, D., Banu, E., Bouziane, A., Banu, A., Scotte, F., Fischer, A. M., et al. (2009). Platelet microparticles: a potential predictive factor of survival in hormone-refractory prostate cancer patients treated with docetaxel-based chemotherapy. Eur. Urol. 56, 479-484. doi: 10.1016/j.eururo.2008.06.038
    • (2009) Eur. Urol , vol.56 , pp. 479-484
    • Helley, D.1    Banu, E.2    Bouziane, A.3    Banu, A.4    Scotte, F.5    Fischer, A.M.6
  • 75
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • Hood, J. L., San, R. S., and Wickline, S. A. (2011). Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 71, 3792-3801. doi: 10.1158/0008-5472.CAN-10-4455
    • (2011) Cancer Res , vol.71 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 77
    • 77049227727 scopus 로고
    • The activation of platelets by plasma
    • Hougie, C. (1955). The activation of platelets by plasma. Br. J. Haematol. 1, 213-222. doi: 10.1111/j.1365-2141.1955.tb05502.x
    • (1955) Br. J. Haematol , vol.1 , pp. 213-222
    • Hougie, C.1
  • 78
    • 84929378248 scopus 로고    scopus 로고
    • Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer
    • Hu, Y., Yan, C., Mu, L., Huang, K., Li, X., Tao, D., et al. (2015). Fibroblast-derived exosomes contribute to chemoresistance through priming cancer stem cells in colorectal cancer. PLoS ONE 10:e0125625. doi: 10.1371/journal.pone.0125625
    • (2015) PLoS ONE , vol.10
    • Hu, Y.1    Yan, C.2    Mu, L.3    Huang, K.4    Li, X.5    Tao, D.6
  • 79
    • 85019682359 scopus 로고    scopus 로고
    • Exosomes derived from hypoxic colorectal cancer cells promote angiogenesis through Wnt4-induced beta-catenin signaling in endothelial cells
    • Huang, Z., and Feng, Y. (2017). Exosomes derived from hypoxic colorectal cancer cells promote angiogenesis through Wnt4-induced beta-catenin signaling in endothelial cells. Oncol. Res. 25, 651-661. doi: 10.3727/096504016X14752792816791
    • (2017) Oncol. Res , vol.25 , pp. 651-661
    • Huang, Z.1    Feng, Y.2
  • 80
    • 78049311759 scopus 로고    scopus 로고
    • Clinical relevance of microparticles from platelets and megakaryocytes
    • Italiano, J. E. Jr., Mairuhu, A. T., and Flaumenhaft, R. (2010). Clinical relevance of microparticles from platelets and megakaryocytes. Curr. Opin. Hematol. 17, 578-584. doi: 10.1097/MOH.0b013e32833e77ee
    • (2010) Curr. Opin. Hematol , vol.17 , pp. 578-584
    • Italiano, J.E.1    Mairuhu, A.T.2    Flaumenhaft, R.3
  • 81
    • 0035892114 scopus 로고    scopus 로고
    • Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment
    • Janowska-Wieczorek, A., Majka, M., Kijowski, J., Baj-Krzyworzeka, M., Reca, R., Turner, A. R., et al. (2001). Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood 98, 3143-3149. doi: 10.1182/blood.V98.10.3143
    • (2001) Blood , vol.98 , pp. 3143-3149
    • Janowska-Wieczorek, A.1    Majka, M.2    Kijowski, J.3    Baj-Krzyworzeka, M.4    Reca, R.5    Turner, A.R.6
  • 82
    • 33746555498 scopus 로고    scopus 로고
    • Enhancing effect of platelet-derived microvesicles on the invasive potential of breast cancer cells
    • Janowska-Wieczorek, A., Marquez-Curtis, L. A., Wysoczynski, M., and Ratajczak, M. Z. (2006). Enhancing effect of platelet-derived microvesicles on the invasive potential of breast cancer cells. Transfusion 46, 1199-1209. doi: 10.1111/j.1537-2995.2006.00871.x
    • (2006) Transfusion , vol.46 , pp. 1199-1209
    • Janowska-Wieczorek, A.1    Marquez-Curtis, L.A.2    Wysoczynski, M.3    Ratajczak, M.Z.4
  • 84
    • 84895744810 scopus 로고    scopus 로고
    • Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors
    • Jeppesen, D. K., Nawrocki, A., Jensen, S. G., Thorsen, K., Whitehead, B., Howard, K. A., Ostenfeld, M. S., et al. (2014). Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors. Proteomics 14, 699-712. doi: 10.1002/pmic.201300452
    • (2014) Proteomics , vol.14 , pp. 699-712
    • Jeppesen, D.K.1    Nawrocki, A.2    Jensen, S.G.3    Thorsen, K.4    Whitehead, B.5    Howard, K.A.6    Ostenfeld, M.S.7
  • 85
    • 84943759485 scopus 로고    scopus 로고
    • Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer
    • Ji, R., Zhang, B., Zhang, X., Xue, J., Yuan, X., Yan, Y., et al. (2015). Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer. Cell Cycle 14, 2473-2483. doi: 10.1080/15384101.2015.1005530
    • (2015) Cell Cycle , vol.14 , pp. 2473-2483
    • Ji, R.1    Zhang, B.2    Zhang, X.3    Xue, J.4    Yuan, X.5    Yan, Y.6
  • 86
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation Association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., and Turbide, C. (1987). Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 262, 9412-9420
    • (1987) J. Biol. Chem , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 87
    • 84964597652 scopus 로고    scopus 로고
    • The biology and function of exosomes in cancer
    • Kalluri, R. (2016). The biology and function of exosomes in cancer. J. Clin. Invest. 126, 1208-1215. doi: 10.1172/JCI81135
    • (2016) J. Clin. Invest , vol.126 , pp. 1208-1215
    • Kalluri, R.1
  • 88
    • 85021081225 scopus 로고    scopus 로고
    • Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
    • Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., et al. (2017). Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature 546, 498-503. doi: 10.1038/nature22341
    • (2017) Nature , vol.546 , pp. 498-503
    • Kamerkar, S.1    LeBleu, V.S.2    Sugimoto, H.3    Yang, S.4    Ruivo, C.F.5    Melo, S.A.6
  • 89
    • 84989937368 scopus 로고    scopus 로고
    • Pre-metastatic niche formation has taken its TOLL
    • Kenific, C. M., Nogues, L., and Lyden, D. (2016). Pre-metastatic niche formation has taken its TOLL. Cancer Cell 30, 189-191. doi: 10.1016/j.ccell.2016.07.012
    • (2016) Cancer Cell , vol.30 , pp. 189-191
    • Kenific, C.M.1    Nogues, L.2    Lyden, D.3
  • 90
    • 0037220119 scopus 로고    scopus 로고
    • Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor
    • Kim, H. K., Song, K. S., Park, Y. S., Kang, Y. H., Lee, Y. J., Lee, K. R., et al. (2003). Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. Eur. J. Cancer 39, 184-191. doi: 10.1016/S0959-8049(02)00596-8
    • (2003) Eur. J. Cancer , vol.39 , pp. 184-191
    • Kim, H.K.1    Song, K.S.2    Park, Y.S.3    Kang, Y.H.4    Lee, Y.J.5    Lee, K.R.6
  • 91
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim, J. W., Wieckowski, E., Taylor, D. D., Reichert, T. E., Watkins, S., and Whiteside, T. L. (2005). Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin. Cancer Res. 11, 1010-1020
    • (2005) Clin. Cancer Res , vol.11 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4    Watkins, S.5    Whiteside, T.L.6
  • 92
    • 84866502787 scopus 로고    scopus 로고
    • Hypoxic enhancement of exosome release by breast cancer cells
    • King, H. W., Michael, M. Z., and Gleadle, J. M. (2012). Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer 12:421. doi: 10.1186/1471-2407-12-421
    • (2012) BMC Cancer , vol.12 , pp. 421
    • King, H.W.1    Michael, M.Z.2    Gleadle, J.M.3
  • 93
    • 85014610090 scopus 로고    scopus 로고
    • DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity
    • Kitai, Y., Kawasaki, T., Sueyoshi, T., Kobiyama, K., Ishii, K. J., Zou, J., et al. (2017). DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity. J. Immunol. 198, 1649-1659. doi: 10.4049/jimmunol.1601694
    • (2017) J. Immunol , vol.198 , pp. 1649-1659
    • Kitai, Y.1    Kawasaki, T.2    Sueyoshi, T.3    Kobiyama, K.4    Ishii, K.J.5    Zou, J.6
  • 94
    • 84964698520 scopus 로고    scopus 로고
    • Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells
    • Kong, J. N., He, Q., Wang, G., Dasgupta, S., Dinkins, M. B., Zhu, G., et al. (2015). Guggulsterone and bexarotene induce secretion of exosome-associated breast cancer resistance protein and reduce doxorubicin resistance in MDA-MB-231 cells. Int. J. Cancer 137, 1610-1620. doi: 10.1002/ijc.29542
    • (2015) Int. J. Cancer , vol.137 , pp. 1610-1620
    • Kong, J.N.1    He, Q.2    Wang, G.3    Dasgupta, S.4    Dinkins, M.B.5    Zhu, G.6
  • 95
    • 84959386845 scopus 로고    scopus 로고
    • Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
    • Kowal, J., Arras, G., Colombo, M., Jouve, M., Morath, J. P., Primdal-Bengtson, B., et al. (2016). Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes. Proc. Natl. Acad. Sci. U.S.A. 113, E968-977. doi: 10.1073/pnas.1521230113
    • (2016) Proc. Natl. Acad. Sci. U.S.A , vol.113 , pp. E968-E977
    • Kowal, J.1    Arras, G.2    Colombo, M.3    Jouve, M.4    Morath, J.P.5    Primdal-Bengtson, B.6
  • 96
  • 97
    • 84876927914 scopus 로고    scopus 로고
    • Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
    • Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringner, M., et al. (2013). Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc. Natl. Acad. Sci. U.S.A. 110, 7312-7317. doi: 10.1073/pnas.1220998110
    • (2013) Proc. Natl. Acad. Sci. U.S.A , vol.110 , pp. 7312-7317
    • Kucharzewska, P.1    Christianson, H.C.2    Welch, J.E.3    Svensson, K.J.4    Fredlund, E.5    Ringner, M.6
  • 98
    • 77955496871 scopus 로고    scopus 로고
    • A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells
    • Lee, H. M., Choi, E.-J., Kim, J. H., Kim, T. D., Kim, Y.-K., Kang, C., et al. (2010). A membranous form of ICAM-1 on exosomes efficiently blocks leukocyte adhesion to activated endothelial cells. Biochem. Biophys. Res. Commun. 397, 251-256. doi: 10.1016/j.bbrc.2010.05.094
    • (2010) Biochem. Biophys. Res. Commun , vol.397 , pp. 251-256
    • Lee, H.M.1    Choi, E.-J.2    Kim, J.H.3    Kim, T.D.4    Kim, Y.-K.5    Kang, C.6
  • 99
    • 84930854098 scopus 로고    scopus 로고
    • CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway
    • Li, C., Liu, D. R., Li, G. G., Wang, H. H., Li, X. W., Zhang, W., et al. (2015). CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World J. Gastroenterol. 21, 6215-6228. doi: 10.3748/wjg.v21.i20.6215
    • (2015) World J. Gastroenterol , vol.21 , pp. 6215-6228
    • Li, C.1    Liu, D.R.2    Li, G.G.3    Wang, H.H.4    Li, X.W.5    Zhang, W.6
  • 100
    • 84966351812 scopus 로고    scopus 로고
    • Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway
    • Li, X., Wang, S., Zhu, R., Li, H., and Han, Q. (2016). Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway. J. Hematol. Oncol. 9:42. doi: 10.1186/s13045-016-0269-y
    • (2016) J. Hematol. Oncol , vol.9 , pp. 42
    • Li, X.1    Wang, S.2    Zhu, R.3    Li, H.4    Han, Q.5
  • 101
    • 84937813758 scopus 로고    scopus 로고
    • Esophageal cancer-derived microvesicles induce regulatory B cells
    • Li, Y., An, J., Huang, S., He, J., and Zhang, J. (2015). Esophageal cancer-derived microvesicles induce regulatory B cells. Cell Biochem. Funct. 33, 308-313. doi: 10.1002/cbf.3115
    • (2015) Cell Biochem. Funct , vol.33 , pp. 308-313
    • Li, Y.1    An, J.2    Huang, S.3    He, J.4    Zhang, J.5
  • 102
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu, C., Yu, S., Zinn, K., Wang, J., Zhang, L., Jia, Y., et al. (2006). Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 176, 1375-1385. doi: 10.4049/jimmunol.176.3.1375
    • (2006) J. Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3    Wang, J.4    Zhang, L.5    Jia, Y.6
  • 103
    • 84944457654 scopus 로고    scopus 로고
    • The exosomes in tumor immunity
    • Liu, Y., Gu, Y., Cao, X., Liu, Y., Gu, Y., and Cao, X. (2017). The exosomes in tumor immunity. Oncoimmunology. 4:e1027472. doi: 10.1080/2162402X.2015.1027472
    • (2017) Oncoimmunology , vol.4
    • Liu, Y.1    Gu, Y.2    Cao, X.3    Liu, Y.4    Gu, Y.5    Cao, X.6
  • 104
    • 84989843940 scopus 로고    scopus 로고
    • Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils
    • Liu, Y., Gu, Y., Han, Y., Zhang, Q., Jiang, Z., Zhang, X., et al. (2016). Tumor exosomal RNAs promote lung pre-metastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils. Cancer Cell 30, 243-256. doi: 10.1016/j.ccell.2016.06.021
    • (2016) Cancer Cell , vol.30 , pp. 243-256
    • Liu, Y.1    Gu, Y.2    Han, Y.3    Zhang, Q.4    Jiang, Z.5    Zhang, X.6
  • 105
    • 77952042113 scopus 로고    scopus 로고
    • Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells
    • Liu, Y., Xiang, X., Zhuang, X., Zhang, S., Liu, C., Cheng, Z., et al. (2010). Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells. Am. J. Pathol. 176, 2490-2499. doi: 10.2353/ajpath.2010.090777
    • (2010) Am. J. Pathol , vol.176 , pp. 2490-2499
    • Liu, Y.1    Xiang, X.2    Zhuang, X.3    Zhang, S.4    Liu, C.5    Cheng, Z.6
  • 106
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles
    • Lötvall, J., Hill, A. F., Hochberg, F., Buzás, E. I., Di Vizio, D., Gardiner, C., et al. (2014). Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles. J. Extracell. Vesicles 3:26913. doi: 10.3402/jev.v3.26913
    • (2014) J. Extracell. Vesicles , vol.3 , pp. 26913
    • Lötvall, J.1    Hill, A.F.2    Hochberg, F.3    Buzás, E.I.4    Di Vizio, D.5    Gardiner, C.6
  • 107
    • 84861191800 scopus 로고    scopus 로고
    • Building the niche: the role of the S100 proteins in metastatic growth
    • Lukanidin, E., and Sleeman, J. P. (2012). Building the niche: the role of the S100 proteins in metastatic growth. Semin. Cancer Biol. 22, 216-225. doi: 10.1016/j.semcancer.2012.02.006
    • (2012) Semin. Cancer Biol , vol.22 , pp. 216-225
    • Lukanidin, E.1    Sleeman, J.P.2
  • 108
    • 84931033158 scopus 로고    scopus 로고
    • Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8 + T Cells: mechanism of immune evasion
    • Lundholm, M., Schroder, M., Nagaeva, O., Baranov, V., Widmark, A., Mincheva-Nilsson, L., et al. (2014). Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8 + T Cells: mechanism of immune evasion. PLoS ONE 9:e108925. doi: 10.1371/journal.pone.0108925
    • (2014) PLoS ONE , vol.9
    • Lundholm, M.1    Schroder, M.2    Nagaeva, O.3    Baranov, V.4    Widmark, A.5    Mincheva-Nilsson, L.6
  • 109
    • 84860849807 scopus 로고    scopus 로고
    • Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro
    • Lv, L. H., Wan, Y. L., Lin, Y., Zhang, W., Yang, M., Li, G. Z., et al. (2012). Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. J. Biol. Chem. 287, 15874-15885. doi: 10.1074/jbc.M112.340588
    • (2012) J. Biol. Chem , vol.287 , pp. 15874-15885
    • Lv, L.H.1    Wan, Y.L.2    Lin, Y.3    Zhang, W.4    Yang, M.5    Li, G.Z.6
  • 110
    • 85028997623 scopus 로고    scopus 로고
    • miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer
    • Ma, M., Chen, S., Liu, Z., Xie, H., Deng, H., Shang, S., et al. (2017). miRNA-221 of exosomes originating from bone marrow mesenchymal stem cells promotes oncogenic activity in gastric cancer. Onco. Targets. Ther. 10, 4161-4171. doi: 10.2147/OTT.S143315
    • (2017) Onco. Targets. Ther , vol.10 , pp. 4161-4171
    • Ma, M.1    Chen, S.2    Liu, Z.3    Xie, H.4    Deng, H.5    Shang, S.6
  • 111
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., and Locati, M. (2004). The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677-686. doi: 10.1016/j.it.2004.09.015
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 112
    • 84946780217 scopus 로고    scopus 로고
    • Exosomes decrease sensitivity of breast cancer cells to adriamycin by delivering microRNAs
    • Mao, L., Li, J., Chen, W. X., Cai, Y. Q., Yu, D. D., Zhong, S. L., et al. (2016). Exosomes decrease sensitivity of breast cancer cells to adriamycin by delivering microRNAs. Tumour Biol. 37, 5247-5256. doi: 10.1007/s13277-015-4402-2
    • (2016) Tumour Biol , vol.37 , pp. 5247-5256
    • Mao, L.1    Li, J.2    Chen, W.X.3    Cai, Y.Q.4    Yu, D.D.5    Zhong, S.L.6
  • 113
    • 38449102676 scopus 로고    scopus 로고
    • Macrophage activation and polarization
    • Martinez, F. O., Sica, A., Mantovani, A., and Locati, M. (2008). Macrophage activation and polarization. Front. Biosci. 13, 453-461. doi: 10.2741/2692
    • (2008) Front. Biosci , vol.13 , pp. 453-461
    • Martinez, F.O.1    Sica, A.2    Mantovani, A.3    Locati, M.4
  • 114
    • 85028608644 scopus 로고    scopus 로고
    • Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells
    • Matsumoto, A., Takahashi, Y., Nishikawa, M., Sano, K., Morishita, M., Charoenviriyakul, C., et al. (2017). Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells. Cancer Sci. 108, 1803-1810. doi: 10.1111/cas.13310
    • (2017) Cancer Sci , vol.108 , pp. 1803-1810
    • Matsumoto, A.1    Takahashi, Y.2    Nishikawa, M.3    Sano, K.4    Morishita, M.5    Charoenviriyakul, C.6
  • 115
    • 84896051709 scopus 로고    scopus 로고
    • The multifaceted functions of neutrophils
    • Mayadas, T. N., Cullere, X., and Lowell, C. A. (2014). The multifaceted functions of neutrophils. Ann. Rev. Pathol. Mech. Dis. 9, 181-218. doi: 10.1146/annurev-pathol-020712-164023
    • (2014) Ann. Rev. Pathol. Mech. Dis , vol.9 , pp. 181-218
    • Mayadas, T.N.1    Cullere, X.2    Lowell, C.A.3
  • 116
    • 84890149349 scopus 로고    scopus 로고
    • Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles
    • Menck, K., Klemm, F., Gross, J. C., and Pukrop, T. (2013). Induction and transport of Wnt 5a during macrophage-induced malignant invasion is mediated by two types of extracellular vesicles. Oncotarget 4, 2057-2066. doi: 10.18632/oncotarget.1336
    • (2013) Oncotarget , vol.4 , pp. 2057-2066
    • Menck, K.1    Klemm, F.2    Gross, J.C.3    Pukrop, T.4
  • 117
    • 84875528275 scopus 로고    scopus 로고
    • The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
    • Merad, M., Sathe, P., Helft, J., Miller, J., and Mortha, A. (2013). The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31, 563-604. doi: 10.1146/annurev-immunol-020711-074950
    • (2013) Annu. Rev. Immunol , vol.31 , pp. 563-604
    • Merad, M.1    Sathe, P.2    Helft, J.3    Miller, J.4    Mortha, A.5
  • 118
    • 0037163104 scopus 로고    scopus 로고
    • Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia
    • Milia, A. F., Salis, M. B., Stacca, T., Pinna, A., Madeddu, P., Trevisani, M., et al. (2002). Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia. Circ. Res. 91, 346-352. doi: 10.1161/01.RES.0000031958.92781.9E
    • (2002) Circ. Res , vol.91 , pp. 346-352
    • Milia, A.F.1    Salis, M.B.2    Stacca, T.3    Pinna, A.4    Madeddu, P.5    Trevisani, M.6
  • 119
    • 84926262086 scopus 로고    scopus 로고
    • Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance
    • Mincheva-Nilsson, L., and Baranov, V. (2014). Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance. Semin. Cancer Biol. 28, 24-30. doi: 10.1016/j.semcancer.2014.02.010
    • (2014) Semin. Cancer Biol , vol.28 , pp. 24-30
    • Mincheva-Nilsson, L.1    Baranov, V.2
  • 120
    • 84928696451 scopus 로고    scopus 로고
    • Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth
    • Morhayim, J., van de Peppel, J., Demmers, J. A., Kocer, G., Nigg, A. L., van Driel, M., et al. (2015). Proteomic signatures of extracellular vesicles secreted by nonmineralizing and mineralizing human osteoblasts and stimulation of tumor cell growth. FASEB J. 29, 274-285. doi: 10.1096/fj.14-261404
    • (2015) FASEB J , vol.29 , pp. 274-285
    • Morhayim, J.1    van Peppel, J.2    Demmers, J.A.3    Kocer, G.4    Nigg, A.L.5    van Driel, M.6
  • 121
    • 18144369346 scopus 로고    scopus 로고
    • A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer
    • Morse, M. A., Garst, J., Osada, T., Khan, S., Hobeika, A., Clay, T. M., et al. (2005). A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J. Transl. Med. 3:9. doi: 10.1186/1479-5876-3-9
    • (2005) J. Transl. Med , vol.3 , pp. 9
    • Morse, M.A.1    Garst, J.2    Osada, T.3    Khan, S.4    Hobeika, A.5    Clay, T.M.6
  • 122
    • 84951310757 scopus 로고    scopus 로고
    • NK cells and cancer: you can teach innate cells new tricks
    • Morvan, M. G., and Lanier, L. L. (2015). NK cells and cancer: you can teach innate cells new tricks. Nat. Rev. Cancer 16, 7-19. doi: 10.1038/nrc.2015.5
    • (2015) Nat. Rev. Cancer , vol.16 , pp. 7-19
    • Morvan, M.G.1    Lanier, L.L.2
  • 123
    • 84957599052 scopus 로고    scopus 로고
    • Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets
    • Muller, L., Mitsuhashi, M., Simms, P., Gooding, W. E., and Whiteside, T. L. (2016). Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets. Sci. Rep. 6:20254. doi: 10.1038/srep20254
    • (2016) Sci. Rep , vol.6 , pp. 20254
    • Muller, L.1    Mitsuhashi, M.2    Simms, P.3    Gooding, W.E.4    Whiteside, T.L.5
  • 124
    • 34848893105 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells
    • Nagaraj, S., and Gabrilovich, D. I. (2007). Myeloid-derived suppressor cells. Adv. Exp. Med. Biol. 601, 213-223. doi: 10.1007/978-0-387-72005-0_22
    • (2007) Adv. Exp. Med. Biol , vol.601 , pp. 213-223
    • Nagaraj, S.1    Gabrilovich, D.I.2
  • 126
    • 0344481893 scopus 로고
    • The platelet-like activity of serum
    • O'Brien, J. R. (1955). The platelet-like activity of serum. Br. J. Haematol. 1, 223-228. doi: 10.1111/j.1365-2141.1955.tb05503.x
    • (1955) Br. J. Haematol , vol.1 , pp. 223-228
    • O'Brien, J.R.1
  • 127
    • 84883465032 scopus 로고    scopus 로고
    • CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma
    • Ohnishi, K., Komohara, Y., Saito, Y., Miyamoto, Y., Watanabe, M., Baba, H., et al. (2013). CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma. Cancer Sci. 104, 1237-1244. doi: 10.1111/cas.12212
    • (2013) Cancer Sci , vol.104 , pp. 1237-1244
    • Ohnishi, K.1    Komohara, Y.2    Saito, Y.3    Miyamoto, Y.4    Watanabe, M.5    Baba, H.6
  • 128
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi, A. F., Grossfeld, G. D., Hayward, S. W., Carroll, P. R., Tlsty, T. D., and Cunha, G. R. (1999). Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59, 5002-5011
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 129
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., et al. (2005). Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348. doi: 10.1016/j.cell.2005.02.034
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6
  • 130
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • Palucka, K., and Banchereau, J. (2012). Cancer immunotherapy via dendritic cells. Nat. Rev. Cancer 12, 265-277. doi: 10.1038/nrc3258
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 131
    • 85014928283 scopus 로고    scopus 로고
    • Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression
    • Pan, L., Liang, W., Fu, M., Huang, Z. H., Li, X., Zhang, W., et al. (2017). Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression. J. Cancer Res. Clin. Oncol. 143, 991-1004. doi: 10.1007/s00432-017-2361-2
    • (2017) J. Cancer Res. Clin. Oncol , vol.143 , pp. 991-1004
    • Pan, L.1    Liang, W.2    Fu, M.3    Huang, Z.H.4    Li, X.5    Zhang, W.6
  • 132
    • 77953142134 scopus 로고    scopus 로고
    • Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes
    • Park, J. E., Tan, H. S., Datta, A., Lai, R. C., Zhang, H., Meng, W., et al. (2010). Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes. Mol. Cell. Proteomics 9, 1085-1099. doi: 10.1074/mcp.M900381-MCP200
    • (2010) Mol. Cell. Proteomics , vol.9 , pp. 1085-1099
    • Park, J.E.1    Tan, H.S.2    Datta, A.3    Lai, R.C.4    Zhang, H.5    Meng, W.6
  • 133
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado, H., Aleckovic, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., et al. (2012). Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883-891. doi: 10.1038/nm.2753
    • (2012) Nat. Med , vol.18 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3    Matei, I.4    Costa-Silva, B.5    Moreno-Bueno, G.6
  • 135
    • 33744960641 scopus 로고    scopus 로고
    • Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells
    • Perone, M. J., Larregina, A. T., Shufesky, W. J., Papworth, G. D., Sullivan, M. L. G., Zahorchak, A. F., et al. (2006). Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses in naive and activated T cells. J. Immunol. 176, 7207-7220. doi: 10.4049/jimmunol.176.12.7207
    • (2006) J. Immunol , vol.176 , pp. 7207-7220
    • Perone, M.J.1    Larregina, A.T.2    Shufesky, W.J.3    Papworth, G.D.4    Sullivan, M.L.G.5    Zahorchak, A.F.6
  • 136
    • 34548625556 scopus 로고    scopus 로고
    • Unsolved mysteries in membrane traffic
    • Pfeffer, S. R. (2007). Unsolved mysteries in membrane traffic. Annu. Rev. Biochem. 76, 629-645. doi: 10.1146/annurev.biochem.76.061705.130002
    • (2007) Annu. Rev. Biochem , vol.76 , pp. 629-645
    • Pfeffer, S.R.1
  • 137
  • 138
    • 84961390149 scopus 로고    scopus 로고
    • SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions
    • Pucci, F., Garris, C., Lai, C. P., Newton, A., Pfirschke, C., Engblom, C., et al. (2016). SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science 352, 242-247. doi: 10.1126/science.aaf1328
    • (2016) Science , vol.352 , pp. 242-247
    • Pucci, F.1    Garris, C.2    Lai, C.P.3    Newton, A.4    Pfirschke, C.5    Engblom, C.6
  • 139
    • 85019895482 scopus 로고    scopus 로고
    • Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner
    • Qin, X., Yu, S., Zhou, L., Shi, M., Hu, Y., Xu, X., et al. (2017). Cisplatin-resistant lung cancer cell-derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100-5p-dependent manner. Int. J. Nanomed. 12, 3721-3733. doi: 10.2147/IJN.S131516
    • (2017) Int. J. Nanomed , vol.12 , pp. 3721-3733
    • Qin, X.1    Yu, S.2    Zhou, L.3    Shi, M.4    Hu, Y.5    Xu, X.6
  • 140
    • 70350747789 scopus 로고    scopus 로고
    • Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation
    • Qu, J. L., Qu, X. J., Zhao, M. F., Teng, Y. E., Zhang, Y., Hou, K. Z., et al. (2009). Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation. Dig. Liver Dis. 41, 875-880. doi: 10.1016/j.dld.2009.04.006
    • (2009) Dig. Liver Dis , vol.41 , pp. 875-880
    • Qu, J.L.1    Qu, X.J.2    Zhao, M.F.3    Teng, Y.E.4    Zhang, Y.5    Hou, K.Z.6
  • 141
    • 84868030361 scopus 로고    scopus 로고
    • Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer
    • Quatromoni, J. G., and Eruslanov, E. (2012). Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer. Am. J. Transl. Res. 4, 376-389
    • (2012) Am. J. Transl. Res , vol.4 , pp. 376-389
    • Quatromoni, J.G.1    Eruslanov, E.2
  • 142
    • 84928669591 scopus 로고    scopus 로고
    • Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism
    • Raimondo, S., Saieva, L., Corrado, C., Fontana, S., Flugy, A., Rizzo, A., et al. (2015). Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism. Cell Commun. Signal. 13:8. doi: 10.1186/s12964-015-0086-x
    • (2015) Cell Commun. Signal , vol.13 , pp. 8
    • Raimondo, S.1    Saieva, L.2    Corrado, C.3    Fontana, S.4    Flugy, A.5    Rizzo, A.6
  • 143
    • 84930763705 scopus 로고    scopus 로고
    • Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules
    • Ramteke, A., Ting, H., Agarwal, C., Mateen, S., Somasagara, R., Hussain, A., et al. (2015). Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. Mol. Carcinog. 54, 554-565. doi: 10.1002/mc.22124
    • (2015) Mol. Carcinog , vol.54 , pp. 554-565
    • Ramteke, A.1    Ting, H.2    Agarwal, C.3    Mateen, S.4    Somasagara, R.5    Hussain, A.6
  • 144
    • 84979030811 scopus 로고    scopus 로고
    • Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro
    • Rao, Q., Zuo, B., Lu, Z., Gao, X., You, A., Wu, C., et al. (2016). Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro. Hepatology 64, 456-472. doi: 10.1002/hep.28549
    • (2016) Hepatology , vol.64 , pp. 456-472
    • Rao, Q.1    Zuo, B.2    Lu, Z.3    Gao, X.4    You, A.5    Wu, C.6
  • 146
    • 84897949075 scopus 로고    scopus 로고
    • Role of exosomes released by dendritic cells and/or by tumor targets: regulation of NK cell plasticity
    • Reiners, K. S., Dassler, J., Coch, C., and Strandmann, E. P. V. (2014). Role of exosomes released by dendritic cells and/or by tumor targets: regulation of NK cell plasticity. Front. Immunol. 5:91. doi: 10.3389/fimmu.2014.00091
    • (2014) Front. Immunol , vol.5 , pp. 91
    • Reiners, K.S.1    Dassler, J.2    Coch, C.3    Strandmann, E.P.V.4
  • 147
    • 33746944049 scopus 로고    scopus 로고
    • BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells
    • Rialland, P., Lankar, D., Raposo, G., Bonnerot, C., and Hubert, P. (2006). BCR-bound antigen is targeted to exosomes in human follicular lymphoma B-cells. Biol. Cell 98, 491-501. doi: 10.1042/BC20060027
    • (2006) Biol. Cell , vol.98 , pp. 491-501
    • Rialland, P.1    Lankar, D.2    Raposo, G.3    Bonnerot, C.4    Hubert, P.5
  • 148
    • 84988726241 scopus 로고    scopus 로고
    • Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells
    • Richards, K. E., Zeleniak, A. E., Fishel, M. L., Wu, J., Littlepage, L. E., and Hill, R. (2017). Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells. Oncogene 36, 1770-1778. doi: 10.1038/onc.2016.353
    • (2017) Oncogene , vol.36 , pp. 1770-1778
    • Richards, K.E.1    Zeleniak, A.E.2    Fishel, M.L.3    Wu, J.4    Littlepage, L.E.5    Hill, R.6
  • 149
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • Robbins, P. D., and Morelli, A. E. (2014). Regulation of immune responses by extracellular vesicles. Nat. Rev. Immunol. 14, 195-208. doi: 10.1038/nri3622
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 150
    • 80054075147 scopus 로고    scopus 로고
    • Tumour macrophages as potential targets of bisphosphonates
    • Rogers, T. L., and Holen, I. (2011). Tumour macrophages as potential targets of bisphosphonates. J. Transl. Med. 9:177. doi: 10.1186/1479-5876-9-177
    • (2011) J. Transl. Med , vol.9 , pp. 177
    • Rogers, T.L.1    Holen, I.2
  • 151
    • 84885952379 scopus 로고    scopus 로고
    • Increased apoptosis and elevated Fas expression in circulating natural killer cells in gastric cancer patients
    • Saito, H., Takaya, S., Osaki, T., and Ikeguchi, M. (2013). Increased apoptosis and elevated Fas expression in circulating natural killer cells in gastric cancer patients. Gastric Cancer 16, 473-479. doi: 10.1007/s10120-012-0210-1
    • (2013) Gastric Cancer , vol.16 , pp. 473-479
    • Saito, H.1    Takaya, S.2    Osaki, T.3    Ikeguchi, M.4
  • 152
    • 84957989918 scopus 로고    scopus 로고
    • Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche
    • Sanchez, C. A., Andahur, E. I., Valenzuela, R., Castellon, E. A., Fulla, J. A., Ramos, C. G., et al. (2016). Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche. Oncotarget 7, 3993-4008. doi: 10.18632/oncotarget.6540
    • (2016) Oncotarget , vol.7 , pp. 3993-4008
    • Sanchez, C.A.1    Andahur, E.I.2    Valenzuela, R.3    Castellon, E.A.4    Fulla, J.A.5    Ramos, C.G.6
  • 153
    • 84892653021 scopus 로고    scopus 로고
    • CD169 mediates the capture of exosomes in spleen and lymph node
    • Saunderson, S. C., Dunn, A. C., Crocker, P. R., and McLellan, A. D. (2014). CD169 mediates the capture of exosomes in spleen and lymph node. Blood 123, 208-216. doi: 10.1182/blood-2013-03-489732
    • (2014) Blood , vol.123 , pp. 208-216
    • Saunderson, S.C.1    Dunn, A.C.2    Crocker, P.R.3    McLellan, A.D.4
  • 154
    • 84885701721 scopus 로고    scopus 로고
    • The tumor microenvironment: a pitch for multiple players
    • Schiavoni, G., Gabriele, L., and Mattei, F. (2013). The tumor microenvironment: a pitch for multiple players. Front. Oncol. 3:90. doi: 10.3389/fonc.2013.00090
    • (2013) Front. Oncol , vol.3 , pp. 90
    • Schiavoni, G.1    Gabriele, L.2    Mattei, F.3
  • 155
    • 22044447897 scopus 로고    scopus 로고
    • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
    • Segura, E., Nicco, C., Lombard, B., Véron, P., Raposo, G., Batteux, F., et al. (2005). ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood 106, 216-223. doi: 10.1182/blood-2005-01-0220
    • (2005) Blood , vol.106 , pp. 216-223
    • Segura, E.1    Nicco, C.2    Lombard, B.3    Véron, P.4    Raposo, G.5    Batteux, F.6
  • 156
    • 84945577498 scopus 로고    scopus 로고
    • Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth
    • Setti, M., Osti, D., Richichi, C., Ortensi, B., Del Bene, M., Fornasari, L., et al. (2015). Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth. Oncotarget 6, 31413-31427. doi: 10.18632/oncotarget.5105
    • (2015) Oncotarget , vol.6 , pp. 31413-31427
    • Setti, M.1    Osti, D.2    Richichi, C.3    Ortensi, B.4    Del Bene, M.5    Fornasari, L.6
  • 157
    • 84981347253 scopus 로고    scopus 로고
    • AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility
    • Silva, T. A., Smuczek, B., Valadao, I. C., Dzik, L. M., Iglesia, R. P., Cruz, M. C., et al. (2016). AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility. Oncotarget 7, 49998-50016. doi: 10.18632/oncotarget.10307
    • (2016) Oncotarget , vol.7 , pp. 49998-50016
    • Silva, T.A.1    Smuczek, B.2    Valadao, I.C.3    Dzik, L.M.4    Iglesia, R.P.5    Cruz, M.C.6
  • 158
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Sena-Esteves, M., et al. (2008). Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470-1476. doi: 10.1038/ncb1800
    • (2008) Nat. Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Würdinger, T.2    van Rijn, S.3    Meijer, D.H.4    Gainche, L.5    Sena-Esteves, M.6
  • 159
    • 34249901006 scopus 로고    scopus 로고
    • Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes
    • Soderberg, A., Barral, A. M., Soderstrom, M., Sander, B., and Rosen, A. (2007). Redox-signaling transmitted in trans to neighboring cells by melanoma-derived TNF-containing exosomes. Free Radic. Biol. Med. 43, 90-99. doi: 10.1016/j.freeradbiomed.2007.03.026
    • (2007) Free Radic. Biol. Med , vol.43 , pp. 90-99
    • Soderberg, A.1    Barral, A.M.2    Soderstrom, M.3    Sander, B.4    Rosen, A.5
  • 160
    • 85019467630 scopus 로고    scopus 로고
    • Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer
    • Soekmadji, C., Riches, J. D., Russell, P. J., Ruelcke, J. E., McPherson, S., Wang, C., et al. (2016). Modulation of paracrine signaling by CD9 positive small extracellular vesicles mediates cellular growth of androgen deprived prostate cancer. Oncotarget 8, 52237-52255. doi: 10.18632/oncotarget.11111
    • (2016) Oncotarget , vol.8 , pp. 52237-52255
    • Soekmadji, C.1    Riches, J.D.2    Russell, P.J.3    Ruelcke, J.E.4    McPherson, S.5    Wang, C.6
  • 161
    • 85034093714 scopus 로고    scopus 로고
    • Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis
    • Sruthi, T. V., Edatt, L., Raji, G. R., K, H., Shankar, S. S., Shankar, V., et al. (2017). Horizontal transfer of miR-23a from hypoxic tumor cell colonies can induce angiogenesis. J. Cell Physiol. 233, 3498-3514. doi: 10.1002/jcp.26202
    • (2017) J. Cell Physiol , vol.233 , pp. 3498-3514
    • Sruthi, T.V.1    Edatt, L.2    Raji, G.R.K.H.3    Shankar, S.S.4    Shankar, V.5
  • 162
    • 80051971645 scopus 로고    scopus 로고
    • Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells
    • Svensson, K. J., Kucharzewska, P., Christianson, H. C., Skold, S., Lofstedt, T., Johansson, M. C., et al. (2011). Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 108, 13147-13152. doi: 10.1073/pnas.1104261108
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 13147-13152
    • Svensson, K.J.1    Kucharzewska, P.2    Christianson, H.C.3    Skold, S.4    Lofstedt, T.5    Johansson, M.C.6
  • 163
    • 84964853782 scopus 로고    scopus 로고
    • Exosome-mediated metastasis: from epithelial-mesenchymal transition to escape from immunosurveillance
    • Syn, N., Wang, L., Sethi, G., Thiery, J.-P. p., and Goh, B.-C. (2016). Exosome-mediated metastasis: from epithelial-mesenchymal transition to escape from immunosurveillance. Trends Pharmacol. Sci. 37, 606-617. doi: 10.1016/j.tips.2016.04.006
    • (2016) Trends Pharmacol. Sci , vol.37 , pp. 606-617
    • Syn, N.1    Wang, L.2    Sethi, G.3    Thiery, J.-P.P.4    Goh, B.-C.5
  • 164
    • 80052384534 scopus 로고    scopus 로고
    • Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β 1
    • Szczepanski, M. J., Szajnik, M., Welsh, A., Whiteside, T. L., and Boyiadzis, M. (2011). Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-β 1. Haematologica 96, 1302-1309. doi: 10.3324/haematol.2010.039743
    • (2011) Haematologica , vol.96 , pp. 1302-1309
    • Szczepanski, M.J.1    Szajnik, M.2    Welsh, A.3    Whiteside, T.L.4    Boyiadzis, M.5
  • 165
    • 84901398883 scopus 로고    scopus 로고
    • Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer
    • Takahashi, K., Yan, I. K., Kogure, T., Haga, H., and Patel, T. (2014). Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer. FEBS Open Bio 4, 458-467. doi: 10.1016/j.fob.2014.04.007
    • (2014) FEBS Open Bio , vol.4 , pp. 458-467
    • Takahashi, K.1    Yan, I.K.2    Kogure, T.3    Haga, H.4    Patel, T.5
  • 166
    • 85020415355 scopus 로고    scopus 로고
    • Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2
    • Takasugi, M., Okada, R., Takahashi, A., Virya Chen, D., Watanabe, S., and Hara, E. (2017). Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. Nat. Commun. 8:15729. doi: 10.1038/ncomms15728
    • (2017) Nat. Commun , vol.8 , pp. 15729
    • Takasugi, M.1    Okada, R.2    Takahashi, A.3    Virya Chen, D.4    Watanabe, S.5    Hara, E.6
  • 167
    • 84857499728 scopus 로고    scopus 로고
    • Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis
    • Taverna, S., Flugy, A., Saieva, L., Kohn, E. C., Santoro, A., Meraviglia, S., et al. (2012). Role of exosomes released by chronic myelogenous leukemia cells in angiogenesis. Int. J. Cancer 130, 2033-2043. doi: 10.1002/ijc.26217
    • (2012) Int. J. Cancer , vol.130 , pp. 2033-2043
    • Taverna, S.1    Flugy, A.2    Saieva, L.3    Kohn, E.C.4    Santoro, A.5    Meraviglia, S.6
  • 168
    • 85028098813 scopus 로고    scopus 로고
    • Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
    • Taylor, D. D., and Gercel-taylor, C. (2011). Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin. Immunopathol. 33, 441-454. doi: 10.1007/s00281-010-0234-8
    • (2011) Semin. Immunopathol , vol.33 , pp. 441-454
    • Taylor, D.D.1    Gercel-taylor, C.2
  • 169
    • 0242525678 scopus 로고    scopus 로고
    • T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    • Taylor, D. D., Gerçel-Taylor, C., Lyons, K. S., Stanson, J., and Whiteside, T. L. (2003). T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors. Clin. Cancer Res. 9, 5113-5119
    • (2003) Clin. Cancer Res , vol.9 , pp. 5113-5119
    • Taylor, D.D.1    Gerçel-Taylor, C.2    Lyons, K.S.3    Stanson, J.4    Whiteside, T.L.5
  • 170
    • 73949102414 scopus 로고    scopus 로고
    • The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway
    • Temme, S., Eis-Hubinger, A. M., McLellan, A. D., and Koch, N. (2010). The herpes simplex virus-1 encoded glycoprotein B diverts HLA-DR into the exosome pathway. J. Immunol. 184, 236-243. doi: 10.4049/jimmunol.0902192
    • (2010) J. Immunol , vol.184 , pp. 236-243
    • Temme, S.1    Eis-Hubinger, A.M.2    McLellan, A.D.3    Koch, N.4
  • 171
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles
    • Théry, C., Boussac, M., Véron, P., Ricciardi-Castagnoli, P., Raposo, G., Garin, J., et al. (2001). Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309-7318. doi: 10.4049/jimmunol.166.12.7309
    • (2001) J. Immunol , vol.166 , pp. 7309-7318
    • Théry, C.1    Boussac, M.2    Véron, P.3    Ricciardi-Castagnoli, P.4    Raposo, G.5    Garin, J.6
  • 172
    • 84875994843 scopus 로고    scopus 로고
    • Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes
    • Thompson, C. A., Purushothaman, A., Ramani, V. C., Vlodavsky, I., and Sanderson, R. D. (2013). Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J. Biol. Chem. 288, 10093-10099. doi: 10.1074/jbc.C112.444562
    • (2013) J. Biol. Chem , vol.288 , pp. 10093-10099
    • Thompson, C.A.1    Purushothaman, A.2    Ramani, V.C.3    Vlodavsky, I.4    Sanderson, R.D.5
  • 173
    • 85019937680 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
    • Tian, H., and Li, W. (2017). Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges. Ann. Transl. Med. 5, 221-221. doi: 10.21037/atm.2017.02.23
    • (2017) Ann. Transl. Med , vol.5 , pp. 221-221
    • Tian, H.1    Li, W.2
  • 174
  • 175
    • 84926298898 scopus 로고    scopus 로고
    • Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier
    • Tominaga, N., Kosaka, N., Ono, M., Katsuda, T., Yoshioka, Y., Tamura, K., et al. (2015). Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier. Nat. Commun. 6, 6716. doi: 10.1038/ncomms7716
    • (2015) Nat. Commun , vol.6 , pp. 6716
    • Tominaga, N.1    Kosaka, N.2    Ono, M.3    Katsuda, T.4    Yoshioka, Y.5    Tamura, K.6
  • 176
    • 54949090343 scopus 로고    scopus 로고
    • Platelet-derived microparticles and coagulation activation in breast cancer patients
    • Toth, B., Liebhardt, S., Steinig, K., Ditsch, N., Rank, A., Bauerfeind, I., et al. (2008). Platelet-derived microparticles and coagulation activation in breast cancer patients. Thromb. Haemost. 100, 663-669. doi: 10.1160/TH07-10-0602
    • (2008) Thromb. Haemost , vol.100 , pp. 663-669
    • Toth, B.1    Liebhardt, S.2    Steinig, K.3    Ditsch, N.4    Rank, A.5    Bauerfeind, I.6
  • 177
    • 85040714285 scopus 로고    scopus 로고
    • Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extracellular vesicles
    • Treps, L., Perret, R., Edmond, S., Ricard, D., and Gavard, J. (2017). Glioblastoma stem-like cells secrete the pro-angiogenic VEGF-A factor in extracellular vesicles. J. Extracell. Vesicles 6:1359479. doi: 10.1080/20013078.2017.1359479
    • (2017) J. Extracell. Vesicles , vol.6
    • Treps, L.1    Perret, R.2    Edmond, S.3    Ricard, D.4    Gavard, J.5
  • 178
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu, T., Ohyashiki, K., Kuroda, M., and Ohyashiki, J. H. (2013). Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 32, 2747-2755. doi: 10.1038/onc.2012.295
    • (2013) Oncogene , vol.32 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.H.4
  • 179
    • 84911390789 scopus 로고    scopus 로고
    • Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways
    • Ung, T. H., Madsen, H. J., Hellwinkel, J. E., Lencioni, A. M., and Graner, M. W. (2014). Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways. Cancer Sci. 105, 1384-1392. doi: 10.1111/cas.12534
    • (2014) Cancer Sci , vol.105 , pp. 1384-1392
    • Ung, T.H.1    Madsen, H.J.2    Hellwinkel, J.E.3    Lencioni, A.M.4    Graner, M.W.5
  • 180
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes
    • Valenti, R., Huber, V., Filipazzi, P., Pilla, L., Sovena, G., Villa, A., et al. (2006). Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res. 66, 9290-9298. doi: 10.1158/0008-5472.CAN-06-1819
    • (2006) Cancer Res , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5    Villa, A.6
  • 181
    • 84907018285 scopus 로고    scopus 로고
    • Small but mighty: microparticles as mediators of tumor progression
    • Voloshin, T., Fremder, E., and Shaked, Y. (2014). Small but mighty: microparticles as mediators of tumor progression. Cancer Microenviron. 7, 11-21. doi: 10.1007/s12307-014-0144-8
    • (2014) Cancer Microenviron , vol.7 , pp. 11-21
    • Voloshin, T.1    Fremder, E.2    Shaked, Y.3
  • 182
    • 84904868088 scopus 로고    scopus 로고
    • Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells
    • Wang, J., Hendrix, A., Hernot, S., Lemaire, M., De Bruyne, E., Van Valckenborgh, E., et al. (2014). Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood 124, 555-566. doi: 10.1182/blood-2014-03-562439
    • (2014) Blood , vol.124 , pp. 555-566
    • Wang, J.1    Hendrix, A.2    Hernot, S.3    Lemaire, M.4    De Bruyne, E.5    Van Valckenborgh, E.6
  • 183
    • 84962885569 scopus 로고    scopus 로고
    • Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression
    • Wang, J., Veirman, K. D., Faict, S., Frassanito, M. A., Ribatti, D., and Vacca, A. (2016). Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression. J. Pathol. 239, 162-173. doi: 10.1002/path.4712
    • (2016) J. Pathol , vol.239 , pp. 162-173
    • Wang, J.1    Veirman, K.D.2    Faict, S.3    Frassanito, M.A.4    Ribatti, D.5    Vacca, A.6
  • 184
    • 84950299450 scopus 로고    scopus 로고
    • Neutrophils support lung colonization of metastasis-initiating breast cancer cells
    • Wculek, S. K., and Malanchi, I. (2015). Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature 528, 413-417. doi: 10.1038/nature16140
    • (2015) Nature , vol.528 , pp. 413-417
    • Wculek, S.K.1    Malanchi, I.2
  • 185
    • 84925446437 scopus 로고    scopus 로고
    • Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes
    • Webber, J. P., Spary, L. K., Sanders, A. J., Chowdhury, R., Jiang, W. G., Steadman, R., et al. (2015). Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes. Oncogene 34, 290-302. doi: 10.1038/onc.2013.560
    • (2015) Oncogene , vol.34 , pp. 290-302
    • Webber, J.P.1    Spary, L.K.2    Sanders, A.J.3    Chowdhury, R.4    Jiang, W.G.5    Steadman, R.6
  • 186
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • Webber, J., Steadman, R., Mason, M. D., Tabi, Z., and Clayton, A. (2010). Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res. 70, 9621-9630. doi: 10.1158/0008-5472.CAN-10-1722
    • (2010) Cancer Res , vol.70 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 187
    • 85021289536 scopus 로고    scopus 로고
    • Malignant ascites-derived exosomes promote proliferation and induce carcinoma-associated fibroblasts transition in peritoneal mesothelial cells
    • Wei, M., Yang, T., Chen, X., Wu, Y., Deng, X., He, W., et al. (2017). Malignant ascites-derived exosomes promote proliferation and induce carcinoma-associated fibroblasts transition in peritoneal mesothelial cells. Oncotarget 8, 42262-42271. doi: 10.18632/oncotarget.15040
    • (2017) Oncotarget , vol.8 , pp. 42262-42271
    • Wei, M.1    Yang, T.2    Chen, X.3    Wu, Y.4    Deng, X.5    He, W.6
  • 188
    • 84930001098 scopus 로고    scopus 로고
    • Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells
    • Wei, Y., Lai, X., Yu, S., Chen, S., Ma, Y., Zhang, Y., et al. (2014). Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. Breast Cancer Res. Treat. 147, 423-431. doi: 10.1007/s10549-014-3037-0
    • (2014) Breast Cancer Res. Treat , vol.147 , pp. 423-431
    • Wei, Y.1    Lai, X.2    Yu, S.3    Chen, S.4    Ma, Y.5    Zhang, Y.6
  • 189
    • 84873149964 scopus 로고    scopus 로고
    • Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)
    • Whiteside, T. L. (2013). Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes). Biochem. Soc. Trans. 41, 245-251. doi: 10.1042/BST20120265
    • (2013) Biochem. Soc. Trans , vol.41 , pp. 245-251
    • Whiteside, T.L.1
  • 190
    • 70349315105 scopus 로고    scopus 로고
    • Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8 + T lymphocytes
    • Wieckowski, E. U., Visus, C., Szajnik, M., Szczepanski, M. J., Storkus, W. J., and Theresa, L. (2009). Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8 + T lymphocytes. J. Immunol. 183, 3720-3730. doi: 10.4049/jimmunol.0900970
    • (2009) J. Immunol , vol.183 , pp. 3720-3730
    • Wieckowski, E.U.1    Visus, C.2    Szajnik, M.3    Szczepanski, M.J.4    Storkus, W.J.5    Theresa, L.6
  • 191
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • Witwer, K. W., Buzás, E. I., Bemis, L. T., Bora, A., Lässer, C., Lötvall, J., et al. (2013). Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J. Extracell. Vesicles 2:20360. doi: 10.3402/jev.v2i0.20360
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20360
    • Witwer, K.W.1    Buzás, E.I.2    Bemis, L.T.3    Bora, A.4    Lässer, C.5    Lötvall, J.6
  • 192
    • 0014082202 scopus 로고
    • The nature and significance of platelet products in human plasma
    • Wolf, P. (1967). The nature and significance of platelet products in human plasma. Br. J. Haematol. 13, 269-288. doi: 10.1111/j.1365-2141.1967.tb08741.x
    • (1967) Br. J. Haematol , vol.13 , pp. 269-288
    • Wolf, P.1
  • 193
    • 84969959966 scopus 로고    scopus 로고
    • Exosomes derived from gastric cancer cells activate NF-kappaB pathway in macrophages to promote cancer progression
    • Wu, L., Zhang, X., Zhang, B., Shi, H., Yuan, X., Sun, Y., et al. (2016). Exosomes derived from gastric cancer cells activate NF-kappaB pathway in macrophages to promote cancer progression. Tumour Biol. 37, 12169-12180. doi: 10.1007/s13277-016-5071-5
    • (2016) Tumour Biol , vol.37 , pp. 12169-12180
    • Wu, L.1    Zhang, X.2    Zhang, B.3    Shi, H.4    Yuan, X.5    Sun, Y.6
  • 194
    • 85020296514 scopus 로고    scopus 로고
    • Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA
    • Wu, Q., Wu, X., Ying, X., Zhu, Q., Wang, X., Jiang, L., et al. (2017). Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is reversed by epithelial ovarian cancer exosomal lncRNA. Cancer Cell Int. 17:62. doi: 10.1186/s12935-017-0430-x
    • (2017) Cancer Cell Int , vol.17 , pp. 62
    • Wu, Q.1    Wu, X.2    Ying, X.3    Zhu, Q.4    Wang, X.5    Jiang, L.6
  • 195
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumor exosomes
    • Xiang, X., Poliakov, A., Liu, C., Liu, Y., Deng, Z. B., and Wang, J. G. (2009). Induction of myeloid-derived suppressor cells by tumor exosomes. Int. J. Cancer 2633, 2621-2633. doi: 10.1002/ijc.24249
    • (2009) Int. J. Cancer , vol.2633 , pp. 2621-2633
    • Xiang, X.1    Poliakov, A.2    Liu, C.3    Liu, Y.4    Deng, Z.B.5    Wang, J.G.6
  • 196
    • 84896760337 scopus 로고    scopus 로고
    • Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin
    • Xiao, X., Yu, S., Li, S., Wu, J., Ma, R., Cao, H., et al. (2014). Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin. PLoS ONE 9:e89534. doi: 10.1371/journal.pone.0089534
    • (2014) PLoS ONE , vol.9
    • Xiao, X.1    Yu, S.2    Li, S.3    Wu, J.4    Ma, R.5    Cao, H.6
  • 197
    • 84894102230 scopus 로고    scopus 로고
    • Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
    • Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., et al. (2014). Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-288. doi: 10.1016/j.immuni.2014.01.006
    • (2014) Immunity , vol.40 , pp. 274-288
    • Xue, J.1    Schmidt, S.V.2    Sander, J.3    Draffehn, A.4    Krebs, W.5    Quester, I.6
  • 198
    • 84860451203 scopus 로고    scopus 로고
    • Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells
    • Yang, C., Chalasani, G., Ng, Y.-H., and Robbins, P. D. (2012). Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells. PLoS ONE 7:e36138. doi: 10.1371/journal.pone.0036138
    • (2012) PLoS ONE , vol.7
    • Yang, C.1    Chalasani, G.2    Ng, Y.-H.3    Robbins, P.D.4
  • 199
    • 79960984966 scopus 로고    scopus 로고
    • Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model
    • Yang, C., Kim, S.-H., Bianco, N. R., and Robbins, P. D. (2011). Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS ONE 6:e22517. doi: 10.1371/journal.pone.0022517
    • (2011) PLoS ONE , vol.6
    • Yang, C.1    Kim, S.-H.2    Bianco, N.R.3    Robbins, P.D.4
  • 200
    • 84883412245 scopus 로고    scopus 로고
    • Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro
    • Yang, L., Wu, X. H., Wang, D., Luo, C. L., and Chen, L. X. (2013). Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro. Mol. Med. Rep. 8, 1272-1278. doi: 10.3892/mmr.2013.1634
    • (2013) Mol. Med. Rep , vol.8 , pp. 1272-1278
    • Yang, L.1    Wu, X.H.2    Wang, D.3    Luo, C.L.4    Chen, L.X.5
  • 201
    • 85019773398 scopus 로고    scopus 로고
    • Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer
    • Yang, S. J., Wang, D. D., Li, J., Xu, H. Z., Shen, H. Y., Chen, X., et al. (2017). Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer. Gene 623, 5-14. doi: 10.1016/j.gene.2017.04.031
    • (2017) Gene , vol.623 , pp. 5-14
    • Yang, S.J.1    Wang, D.D.2    Li, J.3    Xu, H.Z.4    Shen, H.Y.5    Chen, X.6
  • 202
    • 34248141586 scopus 로고    scopus 로고
    • Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modifed tumor cells
    • Yang, Y., Xiu, F., Cai, Z., Wang, J., Wang, Q., Fu, Y., et al., (2007). Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modifed tumor cells. J. Cancer Res. Clin. Oncol. 133, 389-399. doi: 10.1007/s00432-006-0184-7
    • (2007) J. Cancer Res. Clin. Oncol , vol.133 , pp. 389-399
    • Yang, Y.1    Xiu, F.2    Cai, Z.3    Wang, J.4    Wang, Q.5    Fu, Y.6
  • 203
    • 84906212452 scopus 로고    scopus 로고
    • Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma
    • Ye, S. B., Li, Z. L., Luo, D. H., Huang, B. J., and Chen, Y. S. (2014). Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma. Oncotarget 5, 5439-5452. doi: 10.18632/oncotarget.2118
    • (2014) Oncotarget , vol.5 , pp. 5439-5452
    • Ye, S.B.1    Li, Z.L.2    Luo, D.H.3    Huang, B.J.4    Chen, Y.S.5
  • 204
    • 84926151514 scopus 로고    scopus 로고
    • Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth
    • Yin, Y., Cai, X., Chen, X., Liang, H., Zhang, Y., Li, J., et al. (2014). Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Res. 24, 1164-1180. doi: 10.1038/cr.2014.121
    • (2014) Cell Res , vol.24 , pp. 1164-1180
    • Yin, Y.1    Cai, X.2    Chen, X.3    Liang, H.4    Zhang, Y.5    Li, J.6
  • 205
    • 84978701851 scopus 로고    scopus 로고
    • Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages
    • Ying, X., Wu, Q., Wu, X., Zhu, Q., Wang, X., and Jiang, L. (2016). Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages. Oncotarget 7, 43076-43087. doi: 10.18632/oncotarget.9246
    • (2016) Oncotarget , vol.7 , pp. 43076-43087
    • Ying, X.1    Wu, Q.2    Wu, X.3    Zhu, Q.4    Wang, X.5    Jiang, L.6
  • 206
    • 85015232226 scopus 로고    scopus 로고
    • Is the exosome a potential target for cancer immunotherapy?
    • Yoshimura, A., Sawada, K., and Kimura, T. (2017). Is the exosome a potential target for cancer immunotherapy? Ann. Transl. Med. 5:117. doi: 10.21037/atm.2017.01.47
    • (2017) Ann. Transl. Med , vol.5 , pp. 117
    • Yoshimura, A.1    Sawada, K.2    Kimura, T.3
  • 207
    • 84880038924 scopus 로고    scopus 로고
    • Pathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma
    • Yoshizaki, T., Kondo, S., Wakisaka, N., Murono, S., Endo, K., Sugimoto, H., et al. (2013). Pathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma. Cancer Lett. 337, 1-7. doi: 10.1016/j.canlet.2013.05.018
    • (2013) Cancer Lett , vol.337 , pp. 1-7
    • Yoshizaki, T.1    Kondo, S.2    Wakisaka, N.3    Murono, S.4    Endo, K.5    Sugimoto, H.6
  • 208
    • 84983096332 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis
    • You, Y., Shan, Y., Chen, J., Yue, H., You, B., Shi, S., et al. (2015). Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis. Cancer Sci. 106, 1669-1677. doi: 10.1111/cas.12818
    • (2015) Cancer Sci , vol.106 , pp. 1669-1677
    • You, Y.1    Shan, Y.2    Chen, J.3    Yue, H.4    You, B.5    Shi, S.6
  • 209
    • 84944705108 scopus 로고    scopus 로고
    • Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222
    • Yu, D. D., Wu, Y., Zhang, X. H., Lv, M. M., Chen, W. X., Chen, X., et al. (2016). Exosomes from adriamycin-resistant breast cancer cells transmit drug resistance partly by delivering miR-222. Tumour Biol. 37, 3227-3235. doi: 10.1007/s13277-015-4161-0
    • (2016) Tumour Biol , vol.37 , pp. 3227-3235
    • Yu, D.D.1    Wu, Y.2    Zhang, X.H.3    Lv, M.M.4    Chen, W.X.5    Chen, X.6
  • 210
    • 84923005209 scopus 로고    scopus 로고
    • The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding
    • Yue, S., Mu, W., Erb, U., and Zoller, M. (2015). The tetraspanins CD151 and Tspan8 are essential exosome components for the crosstalk between cancer initiating cells and their surrounding. Oncotarget 6, 2366-2384. doi: 10.18632/oncotarget.2958
    • (2015) Oncotarget , vol.6 , pp. 2366-2384
    • Yue, S.1    Mu, W.2    Erb, U.3    Zoller, M.4
  • 211
    • 85004125624 scopus 로고    scopus 로고
    • B lymphocytes and cancer: a love-hate relationship
    • Yuen, G. J., Demissie, E., and Pillai, S. (2016). B lymphocytes and cancer: a love-hate relationship. Trends Cancer 2, 747-757. doi: 10.1016/j.trecan.2016.10.010
    • (2016) Trends Cancer , vol.2 , pp. 747-757
    • Yuen, G.J.1    Demissie, E.2    Pillai, S.3
  • 212
    • 84964445423 scopus 로고    scopus 로고
    • Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
    • Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., et al. (2016). Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife 5:e10250. doi: 10.7554/eLife.10250
    • (2016) Elife , vol.5
    • Zhao, H.1    Yang, L.2    Baddour, J.3    Achreja, A.4    Bernard, V.5    Moss, T.6
  • 213
    • 85017520498 scopus 로고    scopus 로고
    • Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells
    • Zheng, P., Chen, L., Yuan, X., Luo, Q., Liu, Y., Xie, G., et al. (2017). Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells. J. Exp. Clin. Cancer Res. 36:53. doi: 10.1186/s13046-017-0528-y
    • (2017) J. Exp. Clin. Cancer Res , vol.36 , pp. 53
    • Zheng, P.1    Chen, L.2    Yuan, X.3    Luo, Q.4    Liu, Y.5    Xie, G.6
  • 214
    • 84908312386 scopus 로고    scopus 로고
    • Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203
    • Zhou, M., Chen, J., Zhou, L., Chen, W., Ding, G., and Cao, L. (2014). Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203. Cell. Immunol. 292, 65-69. doi: 10.1016/j.cellimm.2014.09.004
    • (2014) Cell. Immunol , vol.292 , pp. 65-69
    • Zhou, M.1    Chen, J.2    Zhou, L.3    Chen, W.4    Ding, G.5    Cao, L.6
  • 215
    • 84898476721 scopus 로고    scopus 로고
    • Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
    • Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., et al. (2014). Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 25, 501-515. doi: 10.1016/j.ccr.2014.03.007
    • (2014) Cancer Cell , vol.25 , pp. 501-515
    • Zhou, W.1    Fong, M.Y.2    Min, Y.3    Somlo, G.4    Liu, L.5    Palomares, M.R.6
  • 216
    • 85022202757 scopus 로고    scopus 로고
    • Exosomes derived from natural killer cells exert therapeutic effect in melanoma
    • Zhu, L., Kalimuthu, S., Gangadaran, P., Oh, J. M., Lee, H. W., Baek, S. H., et al. (2017). Exosomes derived from natural killer cells exert therapeutic effect in melanoma. Theranostics 7, 2732-2745. doi: 10.7150/thno.18752
    • (2017) Theranostics , vol.7 , pp. 2732-2745
    • Zhu, L.1    Kalimuthu, S.2    Gangadaran, P.3    Oh, J.M.4    Lee, H.W.5    Baek, S.H.6
  • 217
    • 81955167406 scopus 로고    scopus 로고
    • Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
    • Zhu, W., Huang, L., Li, Y., Zhang, X., Gu, J., Yan, Y., et al. (2012). Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett. 315, 28-37. doi: 10.1016/j.canlet.2011.10.002
    • (2012) Cancer Lett , vol.315 , pp. 28-37
    • Zhu, W.1    Huang, L.2    Li, Y.3    Zhang, X.4    Gu, J.5    Yan, Y.6
  • 218
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes
    • Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., et al. (1998). Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 4, 594-600. doi: 10.1038/nm0598-594
    • (1998) Nat. Med , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3    Wolfers, J.4    Flament, C.5    Tenza, D.6
  • 219
    • 84988373364 scopus 로고    scopus 로고
    • The biology of extracellular vesicles with focus on platelet microparticles and their role in cancer development and progression
    • Zmigrodzka, M., Guzera, M., Miskiewicz, A., Jagielski, D., and Winnicka, A. (2016). The biology of extracellular vesicles with focus on platelet microparticles and their role in cancer development and progression. Tumour Biol. 37, 14391-14401. doi: 10.1007/s13277-016-5358-6
    • (2016) Tumour Biol , vol.37 , pp. 14391-14401
    • Zmigrodzka, M.1    Guzera, M.2    Miskiewicz, A.3    Jagielski, D.4    Winnicka, A.5


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