메뉴 건너뛰기




Volumn 28, Issue 1, 2014, Pages 24-30

Cancer exosomes and NKG2D receptor-ligand interactions: Impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance

Author keywords

Cancer; Cytotoxicity; Exosomes; Immune suppression; MICA B; NK cells; NKG2D; RAET1; Tumour surveillance; ULBP

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NATURAL KILLER CELL RECEPTOR NKG2D; LIGAND; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K;

EID: 84926262086     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2014.02.010     Document Type: Review
Times cited : (115)

References (66)
  • 1
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer K., Kleijmeer M.J., Heijnen H.F.G., Stoorvogel W., Geuze H.J. Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 2000, 113:3365-3374.
    • (2000) J Cell Sci , vol.113 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.G.3    Stoorvogel, W.4    Geuze, H.J.5
  • 2
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: composition, biogenesis and function
    • Thery C., Zitvogel L., Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002, 2:569-579.
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 3
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C., Ostrowski M., Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009, 9:581-593.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 4
    • 9144273746 scopus 로고    scopus 로고
    • Role of LBPA and Alix in multivesicular liposome formation and endosomal organization
    • Matsua H., Chevallier J., Mayran N., Le Blanc I., Ferguson C., Fauré J., et al. Role of LBPA and Alix in multivesicular liposome formation and endosomal organization. Science 2004, 303:531-534.
    • (2004) Science , vol.303 , pp. 531-534
    • Matsua, H.1    Chevallier, J.2    Mayran, N.3    Le Blanc, I.4    Ferguson, C.5    Fauré, J.6
  • 6
    • 70350593773 scopus 로고    scopus 로고
    • Exosomes in tumor immunity
    • Clayton A., Mason M.D. Exosomes in tumor immunity. Curr Oncol 2009, 16:46-49.
    • (2009) Curr Oncol , vol.16 , pp. 46-49
    • Clayton, A.1    Mason, M.D.2
  • 7
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H., Ekström K., Bossios A., Sjöstrand M., Lee J.J., Lötvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 8
    • 24644440921 scopus 로고    scopus 로고
    • Exosome secretion and red cell maturation: exploring molecular components involved in the docking and fusion of multivesicular bodies in K562 cells
    • Fader C.M., Savina A., Sanchez D., Colombo M.I. Exosome secretion and red cell maturation: exploring molecular components involved in the docking and fusion of multivesicular bodies in K562 cells. Blood Cells Mol Dis 2005, 35:153-157.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 153-157
    • Fader, C.M.1    Savina, A.2    Sanchez, D.3    Colombo, M.I.4
  • 9
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo G., Nijman W., Stoorvogel W. B lymphocytes secrete antigen-presenting vesicles. J Exp Med 1996, 183:1161-1172.
    • (1996) J Exp Med , vol.183 , pp. 1161-1172
    • Raposo, G.1    Nijman, W.2    Stoorvogel, W.3
  • 10
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and a-granules
    • Heijnen H.F.G., Schiel A.E., Fijnheer R., Geuze H.J., Sixma J.J. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and a-granules. Blood 1999, 94:3037-3799.
    • (1999) Blood , vol.94 , pp. 3037-3799
    • Heijnen, H.F.G.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 13
    • 34548619487 scopus 로고    scopus 로고
    • Exosomes with immune modulatory features are present in human breast milk
    • Admyre C., Johansson S.M., Qazi K.R., Filen J.J., Lahesmaa R., Norman M., et al. Exosomes with immune modulatory features are present in human breast milk. J Immunol 2007, 179:1969-1978.
    • (2007) J Immunol , vol.179 , pp. 1969-1978
    • Admyre, C.1    Johansson, S.M.2    Qazi, K.R.3    Filen, J.J.4    Lahesmaa, R.5    Norman, M.6
  • 14
    • 77953922692 scopus 로고    scopus 로고
    • The role of placental exosomes in reproduction
    • Mincheva-Nilsson L., Baranov V. The role of placental exosomes in reproduction. Am J Reprod Immunol 2010, 63:520-533.
    • (2010) Am J Reprod Immunol , vol.63 , pp. 520-533
    • Mincheva-Nilsson, L.1    Baranov, V.2
  • 17
    • 79952159254 scopus 로고    scopus 로고
    • Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
    • Hedlund M., Nagaeva O., Kargl D., Baranov V., Mincheva-Nilsson L. Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells. PLoS ONE 2011, 6:e16899.
    • (2011) PLoS ONE , vol.6 , pp. e16899
    • Hedlund, M.1    Nagaeva, O.2    Kargl, D.3    Baranov, V.4    Mincheva-Nilsson, L.5
  • 18
    • 54049088501 scopus 로고    scopus 로고
    • Exosome secretion including the DNA damage-induced p53-dependent secretory pathway, is severily compromized in TSAP/Steap3-null mice
    • Lespagnol A., Duflaut D., Beekman C., Blanc L., Fiucci G., Marine J.C., et al. Exosome secretion including the DNA damage-induced p53-dependent secretory pathway, is severily compromized in TSAP/Steap3-null mice. Cell Death Diff 2008, 15:1723-1733.
    • (2008) Cell Death Diff , vol.15 , pp. 1723-1733
    • Lespagnol, A.1    Duflaut, D.2    Beekman, C.3    Blanc, L.4    Fiucci, G.5    Marine, J.C.6
  • 20
    • 33646416463 scopus 로고    scopus 로고
    • The regulation of exosome secretion: a nover function of the P53 protein
    • Yu X., Harris S.L., Levine A.J. The regulation of exosome secretion: a nover function of the P53 protein. Cancer Res 2006, 66:4795-4801.
    • (2006) Cancer Res , vol.66 , pp. 4795-4801
    • Yu, X.1    Harris, S.L.2    Levine, A.J.3
  • 21
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers J., Lozier A., Raposo G., Regnault A., Thery C., Masurier C., et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 2001, 3:297-303.
    • (2001) Nat Med , vol.3 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3    Regnault, A.4    Thery, C.5    Masurier, C.6
  • 22
    • 27144529107 scopus 로고    scopus 로고
    • More efficient induction of HLA-A*0201-restricted and carcinoembryonic (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    • Dai S., Wan T., Wang B., Zhou X., Xiu F., Chen T., et al. More efficient induction of HLA-A*0201-restricted and carcinoembryonic (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin Cancer Res 2005, 11:7554-7563.
    • (2005) Clin Cancer Res , vol.11 , pp. 7554-7563
    • Dai, S.1    Wan, T.2    Wang, B.3    Zhou, X.4    Xiu, F.5    Chen, T.6
  • 23
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte response to interleukin-2
    • Clayton A., Mitchell J.P., Court J., Masson M.D., Tabi Z. Human tumor-derived exosomes selectively impair lymphocyte response to interleukin-2. Cancer Res 2007, 67:7458-7466.
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Masson, M.D.4    Tabi, Z.5
  • 24
    • 36348935057 scopus 로고    scopus 로고
    • Malignant ascites derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
    • Runz S., Keller S., Rupp C., Stoeck A., Issa Y., Koensgen D., et al. Malignant ascites derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM. Gynecol Oncol 2007, 107:563-571.
    • (2007) Gynecol Oncol , vol.107 , pp. 563-571
    • Runz, S.1    Keller, S.2    Rupp, C.3    Stoeck, A.4    Issa, Y.5    Koensgen, D.6
  • 25
    • 33644842918 scopus 로고    scopus 로고
    • Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival
    • Mincheva-Nilsson L., Nagaeva O., Chen T., Stendahl U., Antsiferova J., Mogren I., et al. Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival. J Immunol 2006, 176:3585-3592.
    • (2006) J Immunol , vol.176 , pp. 3585-3592
    • Mincheva-Nilsson, L.1    Nagaeva, O.2    Chen, T.3    Stendahl, U.4    Antsiferova, J.5    Mogren, I.6
  • 26
    • 68949117871 scopus 로고    scopus 로고
    • Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function
    • Hedlund M., Stenqvist A-C., Nagaeva O., Kjellberg L., Wulff M., Baranov V., et al. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J Immunol 2009, 183:340-351.
    • (2009) J Immunol , vol.183 , pp. 340-351
    • Hedlund, M.1    Stenqvist, A.-C.2    Nagaeva, O.3    Kjellberg, L.4    Wulff, M.5    Baranov, V.6
  • 27
    • 33745362875 scopus 로고    scopus 로고
    • Efficient induction of antitutmor T cell immunity by exosomes derived from heat-shocked lymphoma cells
    • Chen W., Wang J., Shao C., Liu S., Yu Y., Wang Q., et al. Efficient induction of antitutmor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol 2006, 36:1598-1607.
    • (2006) Eur J Immunol , vol.36 , pp. 1598-1607
    • Chen, W.1    Wang, J.2    Shao, C.3    Liu, S.4    Yu, Y.5    Wang, Q.6
  • 28
    • 59549104365 scopus 로고    scopus 로고
    • MHC-independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models
    • Cho J.A., Lee Y.S., Kim S.H., Ko J.K., Kim C.W. MHC-independent anti-tumor immune responses induced by Hsp70-enriched exosomes generate tumor regression in murine models. Cancer Lett 2009, 275:256-265.
    • (2009) Cancer Lett , vol.275 , pp. 256-265
    • Cho, J.A.1    Lee, Y.S.2    Kim, S.H.3    Ko, J.K.4    Kim, C.W.5
  • 29
    • 10744229153 scopus 로고    scopus 로고
    • Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functiona MHC class I/peptide complexes to dendritic cells
    • André F., Chaput N., Schratz N.E., Flament C., Aubert N., Bernard J., et al. Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functiona MHC class I/peptide complexes to dendritic cells. J Immunol 2004, 172:2126-2136.
    • (2004) J Immunol , vol.172 , pp. 2126-2136
    • André, F.1    Chaput, N.2    Schratz, N.E.3    Flament, C.4    Aubert, N.5    Bernard, J.6
  • 30
    • 10744220836 scopus 로고    scopus 로고
    • Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naïve Tc1 lymphocytes leading to tumor rejection
    • Chaput N., Scharts N.E., André F., Taieb J., Novault S., Bonnaventure P., et al. Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG adjuvants efficiently prime naïve Tc1 lymphocytes leading to tumor rejection. J Immunol 2004, 172:2137-2146.
    • (2004) J Immunol , vol.172 , pp. 2137-2146
    • Chaput, N.1    Scharts, N.E.2    André, F.3    Taieb, J.4    Novault, S.5    Bonnaventure, P.6
  • 31
  • 32
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai S., Wei D., Wu Z., Zhou X., Wei X., Huang H., et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther 2008, 16:782-790.
    • (2008) Mol Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5    Huang, H.6
  • 33
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola G., Rivoltini L., Castelli C., Huber V., Perego P., Deho P., et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J Exp Med 2002, 195:13031316.
    • (2002) J Exp Med , vol.195 , pp. 13031316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3    Huber, V.4    Perego, P.5    Deho, P.6
  • 34
    • 20444453596 scopus 로고    scopus 로고
    • Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape
    • Huber V., Fais S., Iero M., Lugini L., Canese P., Squarcina P., et al. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. Gastroenterology 2005, 128:1796-1804.
    • (2005) Gastroenterology , vol.128 , pp. 1796-1804
    • Huber, V.1    Fais, S.2    Iero, M.3    Lugini, L.4    Canese, P.5    Squarcina, P.6
  • 35
    • 77958553947 scopus 로고    scopus 로고
    • Surface bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of T regulatory cells in malignant effusions
    • Wada J., Onishi H., Suzuki H., Yamasaki A., Nagai S., Morisaki T., et al. Surface bound TGF-beta1 on effusion-derived exosomes participates in maintenance of number and suppressive function of T regulatory cells in malignant effusions. Anticancer Res 2010, 30:3747-3757.
    • (2010) Anticancer Res , vol.30 , pp. 3747-3757
    • Wada, J.1    Onishi, H.2    Suzuki, H.3    Yamasaki, A.4    Nagai, S.5    Morisaki, T.6
  • 36
    • 18844376919 scopus 로고    scopus 로고
    • Exosomes and the MICA-NKG2D system in cancer
    • Clayton A., Tabi Z. Exosomes and the MICA-NKG2D system in cancer. Blood Cell Moll Dis 2005, 34:206-213.
    • (2005) Blood Cell Moll Dis , vol.34 , pp. 206-213
    • Clayton, A.1    Tabi, Z.2
  • 38
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu C., Yu S., Zinn KWang J., Zhang L., Jia Y., Lappes J.C., et al. Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J Immunol 2006, 176:1375-1385.
    • (2006) J Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn Kwang, J.3    Zhang, L.4    Jia, Y.5    Lappes, J.C.6
  • 41
    • 42449088897 scopus 로고    scopus 로고
    • Natural killer cell recognition of missing self
    • Kärre K. Natural killer cell recognition of missing self. Nat Immunol 2008, 9:277-480.
    • (2008) Nat Immunol , vol.9 , pp. 277-480
    • Kärre, K.1
  • 42
    • 0142197631 scopus 로고    scopus 로고
    • Roles of the NKG2D immunoreceptor and its ligands
    • Raulet D.H. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 2003, 3:781-790.
    • (2003) Nat Rev Immunol , vol.3 , pp. 781-790
    • Raulet, D.H.1
  • 43
    • 32244448339 scopus 로고    scopus 로고
    • Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity
    • Chan C.W., Crafton E., Fan H.N., Flook J., Yoshimura K., Skarica M., et al. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med 2006, 12:207-213.
    • (2006) Nat Med , vol.12 , pp. 207-213
    • Chan, C.W.1    Crafton, E.2    Fan, H.N.3    Flook, J.4    Yoshimura, K.5    Skarica, M.6
  • 44
    • 0041422233 scopus 로고    scopus 로고
    • Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its ligands in rheumatoid arthritis
    • Groh V., Bruhl A., El-Gabalawy H., Neldon J.L., Spies T. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its ligands in rheumatoid arthritis. Proc Natl Acad Sci USA 2003, 100:9452-9457.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9452-9457
    • Groh, V.1    Bruhl, A.2    El-Gabalawy, H.3    Neldon, J.L.4    Spies, T.5
  • 46
    • 0345772230 scopus 로고    scopus 로고
    • The double life of NK receptors: stimulation or co-stimulation?
    • Snyder M.R., Weyand C.M., Goronzy J.J. The double life of NK receptors: stimulation or co-stimulation?. Trends Immunol 2004, 25:25-32.
    • (2004) Trends Immunol , vol.25 , pp. 25-32
    • Snyder, M.R.1    Weyand, C.M.2    Goronzy, J.J.3
  • 49
    • 0037388134 scopus 로고    scopus 로고
    • Transforming grouth factor beta 1 inhibits expression of NKP30 and NKG2D receptors: consequenses for the NK-mediated killing of dendritic cells
    • Castriconi R., Cantoni C., Della Chiesa M., Vitale M., Marcenaro E., Conte R., et al. Transforming grouth factor beta 1 inhibits expression of NKP30 and NKG2D receptors: consequenses for the NK-mediated killing of dendritic cells. Proc Natl Acad Sci USA 2003, 100:4120-4125.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4120-4125
    • Castriconi, R.1    Cantoni, C.2    Della Chiesa, M.3    Vitale, M.4    Marcenaro, E.5    Conte, R.6
  • 51
    • 33847019645 scopus 로고    scopus 로고
    • DNAX assesory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
    • Carlsten M., Björkström N.K., Norell H., Bryceson Y., van Hall T., Baumann B.C., et al. DNAX assesory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. Cancer Res 2007, 67:1317-1325.
    • (2007) Cancer Res , vol.67 , pp. 1317-1325
    • Carlsten, M.1    Björkström, N.K.2    Norell, H.3    Bryceson, Y.4    van Hall, T.5    Baumann, B.C.6
  • 52
    • 0028198760 scopus 로고
    • A second lineage of mammalian major histocompatibility complex class I genes
    • Barham S., Bresnahan M., Geraghty D.E., Spies T. A second lineage of mammalian major histocompatibility complex class I genes. Proc Natl Acad Sci USA 1994, 91:6259-6263.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6259-6263
    • Barham, S.1    Bresnahan, M.2    Geraghty, D.E.3    Spies, T.4
  • 53
    • 0035099068 scopus 로고    scopus 로고
    • ULBPs, novel MHC class-I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
    • Cosman D., Mullberg J., Sutherland C.L., Chin W., Armitage R., Fanslow W., et al. ULBPs, novel MHC class-I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001, 14:123-133.
    • (2001) Immunity , vol.14 , pp. 123-133
    • Cosman, D.1    Mullberg, J.2    Sutherland, C.L.3    Chin, W.4    Armitage, R.5    Fanslow, W.6
  • 55
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histiotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    • Pende D., Rivera P., Marcenaro S., Chang C.C., Biassoni R., Conte R., et al. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histiotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity. Cancer Res 2002, 62:6178-6186.
    • (2002) Cancer Res , vol.62 , pp. 6178-6186
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3    Chang, C.C.4    Biassoni, R.5    Conte, R.6
  • 56
    • 53549124398 scopus 로고    scopus 로고
    • NKG2D ligands in tumor immunity
    • Nausch N., Cerwenka A. NKG2D ligands in tumor immunity. Oncogene 2008, 27:5944-5958.
    • (2008) Oncogene , vol.27 , pp. 5944-5958
    • Nausch, N.1    Cerwenka, A.2
  • 57
    • 24144443517 scopus 로고    scopus 로고
    • The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
    • Gasser S., Orsulic S., Brown E.J., Raulet D.H. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature 2005, 436:1186-1190.
    • (2005) Nature , vol.436 , pp. 1186-1190
    • Gasser, S.1    Orsulic, S.2    Brown, E.J.3    Raulet, D.H.4
  • 58
    • 41549163195 scopus 로고    scopus 로고
    • NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy
    • Guerra N., Tan Y.X., Jincker N.T., Choy A., Gallardo F., Xiong N., et al. NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. Immunity 2008, 28:571-580.
    • (2008) Immunity , vol.28 , pp. 571-580
    • Guerra, N.1    Tan, Y.X.2    Jincker, N.T.3    Choy, A.4    Gallardo, F.5    Xiong, N.6
  • 59
    • 0034866114 scopus 로고    scopus 로고
    • Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60
    • O'Callaghan C.A., Cerwenka A., Willcox B.E., Lanier L.L., Bjorkman P.J. Molecular competition for NKG2D: H60 and RAE1 compete unequally for NKG2D with dominance of H60. Immunity 2001, 15:2012011.
    • (2001) Immunity , vol.15 , pp. 2012011
    • O'Callaghan, C.A.1    Cerwenka, A.2    Willcox, B.E.3    Lanier, L.L.4    Bjorkman, P.J.5
  • 62
    • 65249106175 scopus 로고    scopus 로고
    • Brief residence at the plasma membrane of the MHC class I. related chain B is due to clathrin-mediated cholesterol-dependent endocytosis and shedding
    • Aguera-Gonzalez S., Boutet P., Peyburn H.T., Vales-Gomez M. Brief residence at the plasma membrane of the MHC class I. related chain B is due to clathrin-mediated cholesterol-dependent endocytosis and shedding. J Immunol 2009, 182:4800-4808.
    • (2009) J Immunol , vol.182 , pp. 4800-4808
    • Aguera-Gonzalez, S.1    Boutet, P.2    Peyburn, H.T.3    Vales-Gomez, M.4
  • 63
    • 76549099879 scopus 로고    scopus 로고
    • Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells on exosomes
    • Ashiru O., Botet P., Fernandez-Messina L., Aguera-Gonzalea S., Skepper J.N., Vales-Gomes M., et al. Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells on exosomes. Cancer Res 2010, 70:481-489.
    • (2010) Cancer Res , vol.70 , pp. 481-489
    • Ashiru, O.1    Botet, P.2    Fernandez-Messina, L.3    Aguera-Gonzalea, S.4    Skepper, J.N.5    Vales-Gomes, M.6
  • 64
    • 63449129623 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15 Ra
    • Viaud S., Terme M., Flament C., Taieb J., Andre F., Novault S., et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15 Ra. PLoS ONE 2009, 4:e4942.
    • (2009) PLoS ONE , vol.4 , pp. e4942
    • Viaud, S.1    Terme, M.2    Flament, C.3    Taieb, J.4    Andre, F.5    Novault, S.6
  • 65
    • 84874243786 scopus 로고    scopus 로고
    • Human NKG2D-ligands: cell biology strategies to ensure immune recognition
    • Fernandes-Messina L., Reyburn H.T., Vales-Gomez M. Human NKG2D-ligands: cell biology strategies to ensure immune recognition. Frontiers Immunol 2012, 10.3389/fimmu. 2012.00299.
    • (2012) Frontiers Immunol
    • Fernandes-Messina, L.1    Reyburn, H.T.2    Vales-Gomez, M.3
  • 66
    • 42649119742 scopus 로고    scopus 로고
    • Soluble NKG2D ligands; prevalence, release and functional impact
    • Salih H.R., Holdenrieder S., Steinle A. Soluble NKG2D ligands; prevalence, release and functional impact. Front Biosci 2008, 13:3448-4356.
    • (2008) Front Biosci , vol.13 , pp. 3448-4356
    • Salih, H.R.1    Holdenrieder, S.2    Steinle, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.