Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells

European Journal of Immunology

Volumn 36, Issue 6, 2006, Pages 1598-1607

  Chen, Weilin ^a,b   Wang, Jianli ^a   Shao, Chuansen ^a   Liu, Shuxun ^b   Yu, Yizhi ^b   Wang, Qingqing ^a   Cao, Xuetao ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Dendritic cells; Exosomes; Heat shock; Immunotherapy; Lymphoma

Indexed keywords

CD40 ANTIGEN; CD86 ANTIGEN; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 90; INTERLEUKIN 1BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RANTES; TUMOR CELL VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; B CELL LYMPHOMA; CANCER IMMUNIZATION; CANCER IMMUNOTHERAPY; CANCER PREVENTION; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL SECRETION; CELL STRUCTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG POTENCY; FEMALE; HEAT SHOCK; IMMUNOGENICITY; IMMUNOSTIMULATION; LYMPHOMA CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TUMOR IMMUNITY; TUMOR REJECTION;

ANIMALS; AUTOANTIGENS; CANCER VACCINES; CELL LINE, TUMOR; CHAPERONIN 60; COLONIC NEOPLASMS; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; HEAT-SHOCK RESPONSE; HSP90 HEAT-SHOCK PROTEINS; IMMUNOTHERAPY; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOMA, B-CELL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; T-LYMPHOCYTES;

EID: 33745362875     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535501     Document Type: Article

References (31)

1. Zeng, Y., Feng, H. P., Graner, M. W. and Katsanis, E., Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity. Blood 2003.101: 4485-4491.
2. Feng, H. P., Zeng, Y., Whitesell, L. and Katsanis, E., Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood 2001. 97. 3505-3512.
3. Zitvogel L, Regnault A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P. et al., Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes. Nat. Med. 1998. 4: 594-600.
4. Malin, K., Samuel, L, Ulf, D., Helena, K., Inger, P. and Esbjorn, T., "Tolerosomes" are produced by intestinal epithelial cells. Eur. J. Immunol. 2001. 31: 2892-2900.
5. Wolfers, J., Lozier, A., Raposo, G., Regnault A., Thery, C., Masurier, C., Flament, C. et al., Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 2001. 7: 297-303.
6. Andre, F., Schartz, N. E., Movassagh, M., Flament C., Pautier, P., Morice, P., Pomel, C. et al., Malignant ascitis accumulate immunogenic tumor-derived exosomes: Novel approach for cancer immunotherapy. Lancet 2002. 360: 295-305.
7. Thery, C., Regnault, A., Garin, J., Wolfers, J., Zitvogel, L, Ricciardi-Castagnoli, P., Raposo, G. et al., Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein HSC73. J. Cell. Biol. 1999. 147: 599-610.
8. Altieri, S. L, Khan, A. N. and Tomasi, T. B., Exosomes from plasmacytoma cells as a tumor vaccine. J. Immunother. 2004. 27. 282-288.
9. Srivastava, P. K., Interaction of heat shock proteins with peptides and antigen presenting cells: Chaperoning of the innate and adaptive immune responses. Anna. Rev. Immunol. 2002. 20: 395-425.
10. Todryk, S. M., Eaton, J., Birchall, L., Greenhalgh R., Soars, D., Dalgleish, A. G., Melcher, A. A. and Pandha, H. S., Heated tumour cells of autologous and allogeneic origin elicit anti-tumour immunity. Cancer Immunol. Immunother. 2004. 53: 323-330.
11. Lancaster, G. I. and Febbraio, M. A., Exosome-dependent trafficking of HSP70: A novel secretory pathway for cellular stress proteins. J. Biol, Chem. 2005. 280: 23349-23355.
12. Chaput, N., Taieb, J., Schartz, N. E., Andre, F., Angevin, E. and Zitvogel, L., Exosome-based immunotherapy. Cancer Immunol. Immunother. 2004. 53: 234-239.
13. Banchereau, J. and Steinman, R. M., Dendritic cells and the control of immunity. Nature 1998. 392: 245-252.
14. Andre, F., Schartz, N. E., Movassagh, M., Flament, C., Pautier, P., Morice, P., Pomel, C. et al., Malignant effusions and immunogenic tumor-derived exosomes. Lancet 2002. 360: 295-305.
15. Andre, F., Schartz, N. E., Chaput N., Flament C., Raposo, G., Amigorena, S. and Zitvogel, L., Tumor-derived exosomes: A new source of tumor rejection antigens. Vaccine 2002. 20 Suppl 4: A28-A31.
16. Thery, C., Zitvogel L. and Amigorena, S., Exosomes: Composition, biogenesis and function. Nat. Immunol. 2002. 2: 569-579.
17. Stoorvogel, W., Kleijmeer, M.J., Geuze, H. and Raposo, G., The biogenesis and functions of exosomes. Traffic 2002. 3: 321-330.
18. Van-Eden, W., Ver-der Zee, R. and Prakken, B., Heat-shock proteins induce T-cell regulation of chronic inflammation. Nat. Rev. Immunol. 2005. 5: 318-330.
19. Srivastava, P. K. , Menoret, A., Basu, S., Binder R. J. and Mcquade, K. L., Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world. Immunity 1998. 8: 657-665.
20. Arnold D. S., Hanau, D., Spehner, D., Schmid, C., Rammensee, H. G., Salle, H. and Schil, H., Receptor-mediated endocytosis of heat shock proteins by professional antigen presenting cells. J. Immunol. 1999. 162: 3757-3760.
21. Feng, H. P., Zeng, Y., Graner, M. W., Likhacheva, A. and Katsanis, E., Exogenous stressed proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood 2003. 101: 245-252.
22. Skokos, D., Le-Panse, S., Villa, I., Rousselle, J. C., Peronet, R., David, B., Namane, A. et al., Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J. Immunol. 2001. 166: 868-876.
23. Cho, B.K., Palliser, D., Guillen, E., Wisniewski, J., Young, R. A., Chen, J. and Eisen, H. N., A proposed mechanism for the induction of cytotoxic T lymphocyte production by heat shock fusion proteins. Immunity 2000. 12: 263-272.
24. Chen, W., Syldath, U., Bellmann, K. Burkart, V. and Kolb, H., Human 60-kDa heat-shock protein: A danger signal to the innate immune system. J. Immunol. 1999. 162: 3212-3219.
25. Hsu, D. H., Paz, P., Villaflor, G., Rivas, A., Mehta-Damani, A., Angevin, E., Zitvogel, L .et al., Exosomes as a tumor vaccine: Enhancing potency through direct loading of antigenic peptides. J. Immunother. 2003. 26: 440-450.
26. Andre, F., Escudier, B., Angevin, E., Tursz, T. and Zitvogel, L., Exosomes for cancer immunotherapy. Ann. Oncol. 2004. 15 Suppl 4: 141-144.
27. Banchereau, J. and Palucka, A. K., Dendritic cells as therapeutic vaccines against cancer. Nat. Rev. Immunol. 2005. 5: 296-306.
28. Escola, J. M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O. and Geuze, H. J., Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B lymphocytes. J. Biol. Chem. 1998. 273: 20121-20127
29. Harding, C., Heuser, J. and Stahl, P., Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes: Demonstration of a pathway for receptor shedding. Eur. J. Cell Biol. 1984. 35: 256-263.
30. Chen, T., Guo, J., Yang, M., Han, C., Zhang, M., Chen, W., Liu, Q. et al., Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood 2004. 103: 413-421.
31. Bai X. F., Liu, J., May, K. F., Guo, Y., Zheng, P. and Liu, Y., B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo. Blood 2002. 99: 2880-2889.