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Volumn 126, Issue 4, 2016, Pages 1224-1232

Dendritic cell-derived exosomes for cancer therapy

(7)  Pitt, Jonathan M a,b,c   André, Fabrice a,c,d,e   Amigorena, Sebastian f   Soria, Jean Charles a,c,d,g   Eggermont, Alexander a   Kroemer, Guido h,i,j,k,l,m,n   Zitvogel, Laurence a,b,c,f,o  

b INSERM   (France)
i GRCC   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER IMMUNOTHERAPY; CELL FUNCTION; CELLULAR SECRETION; DENDRITIC CELL; EXOSOME; HUMAN; IMMUNOCOMPETENT CELL; MEMBRANE VESICLE; MOLECULAR INTERACTION; NATURAL KILLER CELL; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; ANIMAL; CELLULAR IMMUNITY; IMMUNOLOGY; IMMUNOTHERAPY; NEOPLASMS; PATHOLOGY; PROCEDURES;

EID: 84964597343     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI81137     Document Type: Review
Times cited : (467)

References (76)
  • 1
    • 84857793524 scopus 로고    scopus 로고
    • Decisions about dendritic cells: Past, present, and future
    • Steinman RM. Decisions about dendritic cells: past, present, and future. Annu Rev Immunol. 2012;30:1-22.
    • (2012) Annu Rev Immunol. , vol.30 , pp. 1-22
    • Steinman, R.M.1
  • 2
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I. Oncology meets immunology: The cancer-immunity cycle. Immunity. 2013;39(1):1-10.
    • (2013) Immunity. , vol.39 , Issue.1 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 3
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363(5):411-422.
    • (2010) N Engl J Med. , vol.363 , Issue.5 , pp. 411-422
    • Kantoff, P.W.1
  • 4
    • 84906098610 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes as immunotherapies in the fight against cancer
    • Pitt JM, et al. Dendritic cell-derived exosomes as immunotherapies in the fight against cancer. J Immunol. 2014;193(3):1006-1011.
    • (2014) J Immunol. , vol.193 , Issue.3 , pp. 1006-1011
    • Pitt, J.M.1
  • 6
    • 84918816477 scopus 로고    scopus 로고
    • Immunotherapeutic potential of extracellular vesicles
    • Zhang B, Yin Y, Lai RC, Lim SK. Immunotherapeutic potential of extracellular vesicles. Front Immunol. 2014;5:518.
    • (2014) Front Immunol. , vol.5 , pp. 518
    • Zhang, B.1    Yin, Y.2    Lai, R.C.3    Lim, S.K.4
  • 7
    • 0029997017 scopus 로고    scopus 로고
    • Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts
    • Gabrilovich DI, Ciernik IF, Carbone DP. Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts. Cell Immunol. 1996;170(1):101-110.
    • (1996) Cell Immunol. , vol.170 , Issue.1 , pp. 101-110
    • Gabrilovich, D.I.1    Ciernik, I.F.2    Carbone, D.P.3
  • 8
    • 84936980504 scopus 로고    scopus 로고
    • Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
    • Melo SA, et al. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015;523(7559):177-182.
    • (2015) Nature. , vol.523 , Issue.7559 , pp. 177-182
    • Melo, S.A.1
  • 9
    • 84964649244 scopus 로고    scopus 로고
    • Prostasomes as a source of diagnostic biomarkers for prostate cancer
    • Zijlstra C, Stoorvogel W. Prostasomes as a source of diagnostic biomarkers for prostate cancer. J Clin Invest. 2016;126(4):1144-1151.
    • (2016) J Clin Invest. , vol.126 , Issue.4 , pp. 1144-1151
    • Zijlstra, C.1    Stoorvogel, W.2
  • 10
    • 84964691275 scopus 로고    scopus 로고
    • Versatile roles of extracellular vesicles in cancer
    • Kosaka N, Yoshioka Y, Fujita Y, Ochiya T. Versatile roles of extracellular vesicles in cancer. J Clin Invest. 2016;126(4):1163-1172.
    • (2016) J Clin Invest. , vol.126 , Issue.4 , pp. 1163-1172
    • Kosaka, N.1    Yoshioka, Y.2    Fujita, Y.3    Ochiya, T.4
  • 11
    • 84964691188 scopus 로고    scopus 로고
    • Exosomes and tumor-mediated immune suppression
    • Whiteside TL. Exosomes and tumor-mediated immune suppression. J Clin Invest. 2016;126(4):1216-1223.
    • (2016) J Clin Invest. , vol.126 , Issue.4 , pp. 1216-1223
    • Whiteside, T.L.1
  • 12
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol. 2009;9(8):581-593.
    • (2009) Nat Rev Immunol. , vol.9 , Issue.8 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 13
    • 84874354368 scopus 로고    scopus 로고
    • Exosomes: Looking back three decades and into the future
    • Harding CV, Heuser JE, Stahl PD. Exosomes: looking back three decades and into the future. J Cell Biol. 2013;200(4):367-371.
    • (2013) J Cell Biol. , vol.200 , Issue.4 , pp. 367-371
    • Harding, C.V.1    Heuser, J.E.2    Stahl, P.D.3
  • 14
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • Robbins PD, Morelli AE. Regulation of immune responses by extracellular vesicles. Nat Rev Immunol. 2014;14(3):195-208.
    • (2014) Nat Rev Immunol. , vol.14 , Issue.3 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 15
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • Thery C, et al. Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles. J Immunol. 2001;166(12):7309-7318.
    • (2001) J Immunol. , vol.166 , Issue.12 , pp. 7309-7318
    • Thery, C.1
  • 16
    • 0040089526 scopus 로고    scopus 로고
    • Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
    • Thery C, et al. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol. 1999;147(3):599-610.
    • (1999) J Cell Biol. , vol.147 , Issue.3 , pp. 599-610
    • Thery, C.1
  • 17
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes
    • Zitvogel L, et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med. 1998;4(5):594-600.
    • (1998) Nat Med. , vol.4 , Issue.5 , pp. 594-600
    • Zitvogel, L.1
  • 18
    • 84865707920 scopus 로고    scopus 로고
    • Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity
    • Tamura Y, et al. Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity. Immunotherapy. 2012;4(8):841-852.
    • (2012) Immunotherapy. , vol.4 , Issue.8 , pp. 841-852
    • Tamura, Y.1
  • 19
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.
    • (2007) Nat Cell Biol. , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 20
    • 84925686613 scopus 로고    scopus 로고
    • Exosome and exosomal microRNA: Trafficking, sorting, and function
    • Zhang J, et al. Exosome and exosomal microRNA: trafficking, sorting, and function. Genomics Proteomics Bioinformatics. 2015;13(1):17-24.
    • (2015) Genomics Proteomics Bioinformatics. , vol.13 , Issue.1 , pp. 17-24
    • Zhang, J.1
  • 21
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • Montecalvo A, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012;119(3):756-766.
    • (2012) Blood. , vol.119 , Issue.3 , pp. 756-766
    • Montecalvo, A.1
  • 22
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo G, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med. 1996;183(3):1161-1172.
    • (1996) J Exp Med. , vol.183 , Issue.3 , pp. 1161-1172
    • Raposo, G.1
  • 23
    • 33746238574 scopus 로고    scopus 로고
    • Direct exosome stimulation of peripheral human T cells detected by ELISPOT
    • Admyre C, Johansson SM, Paulie S, Gabrielsson S. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur J Immunol. 2006;36(7):1772-1781.
    • (2006) Eur J Immunol. , vol.36 , Issue.7 , pp. 1772-1781
    • Admyre, C.1    Johansson, S.M.2    Paulie, S.3    Gabrielsson, S.4
  • 24
    • 0141862085 scopus 로고    scopus 로고
    • MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells
    • Utsugi-Kobukai S, Fujimaki H, Hotta C, Nakazawa M, Minami M. MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells. Immunol Lett. 2003;89(2-3):125-131.
    • (2003) Immunol Lett. , vol.89 , Issue.2-3 , pp. 125-131
    • Utsugi-Kobukai, S.1    Fujimaki, H.2    Hotta, C.3    Nakazawa, M.4    Minami, M.5
  • 25
    • 34948874323 scopus 로고    scopus 로고
    • T cellinduced secretion of MHC class II-peptide complexes on B cell exosomes
    • Muntasell A, Berger AC, Roche PA. T cellinduced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J. 2007;26(19):4263-4272.
    • (2007) EMBO J. , vol.26 , Issue.19 , pp. 4263-4272
    • Muntasell, A.1    Berger, A.C.2    Roche, P.A.3
  • 26
    • 49149111236 scopus 로고    scopus 로고
    • Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition
    • Montecalvo A, et al. Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol. 2008;180(5):3081-3090.
    • (2008) J Immunol. , vol.180 , Issue.5 , pp. 3081-3090
    • Montecalvo, A.1
  • 27
    • 0036319374 scopus 로고    scopus 로고
    • Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells
    • Vincent-Schneider H, et al. Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells. Int Immunol. 2002;14(7):713-722.
    • (2002) Int Immunol. , vol.14 , Issue.7 , pp. 713-722
    • Vincent-Schneider, H.1
  • 28
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes
    • Thery C, Duban L, Segura E, Veron P, Lantz O, Amigorena S. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol. 2002;3(12):1156-1162.
    • (2002) Nat Immunol. , vol.3 , Issue.12 , pp. 1156-1162
    • Thery, C.1    Duban, L.2    Segura, E.3    Veron, P.4    Lantz, O.5    Amigorena, S.6
  • 29
    • 10744229153 scopus 로고    scopus 로고
    • Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells
    • Andre F, et al. Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I/peptide complexes to dendritic cells. J Immunol. 2004;172(4):2126-2136.
    • (2004) J Immunol. , vol.172 , Issue.4 , pp. 2126-2136
    • Andre, F.1
  • 30
    • 79953238006 scopus 로고    scopus 로고
    • Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection
    • Wakim LM, Bevan MJ. Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection. Nature. 2011;471(7340):629-632.
    • (2011) Nature. , vol.471 , Issue.7340 , pp. 629-632
    • Wakim, L.M.1    Bevan, M.J.2
  • 31
    • 78650672083 scopus 로고    scopus 로고
    • Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: A critical role of interferon-γ
    • Viaud S, et al. Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: A critical role of interferon-γ. J Immunother. 2011;34(1):65-75.
    • (2011) J Immunother. , vol.34 , Issue.1 , pp. 65-75
    • Viaud, S.1
  • 32
    • 24644485206 scopus 로고    scopus 로고
    • Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses
    • Segura E, Amigorena S, Thery C. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol Dis. 2005;35(2):89-93.
    • (2005) Blood Cells Mol Dis. , vol.35 , Issue.2 , pp. 89-93
    • Segura, E.1    Amigorena, S.2    Thery, C.3
  • 33
    • 22044447897 scopus 로고    scopus 로고
    • ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
    • Segura E, et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood. 2005;106(1):216-223.
    • (2005) Blood. , vol.106 , Issue.1 , pp. 216-223
    • Segura, E.1
  • 34
    • 34247607233 scopus 로고    scopus 로고
    • T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells
    • Mallegol J, et al. T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology. 2007;132(5):1866-1876.
    • (2007) Gastroenterology. , vol.132 , Issue.5 , pp. 1866-1876
    • Mallegol, J.1
  • 35
    • 84920065898 scopus 로고    scopus 로고
    • Antigen presentation by MHCdressed cells
    • Nakayama M. Antigen presentation by MHCdressed cells. Front Immunol. 2014;5:672.
    • (2014) Front Immunol. , vol.5 , pp. 672
    • Nakayama, M.1
  • 36
    • 84929272789 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes may be a tool for cancer immunotherapy by converting tumor cells into immunogenic targets
    • Romagnoli GG, Zelante BB, Toniolo PA, Migliori IK, Barbuto JA. Dendritic cell-derived exosomes may be a tool for cancer immunotherapy by converting tumor cells into immunogenic targets. Front Immunol. 2014;5:692.
    • (2014) Front Immunol. , vol.5 , pp. 692
    • Romagnoli, G.G.1    Zelante, B.B.2    Toniolo, P.A.3    Migliori, I.K.4    Barbuto, J.A.5
  • 37
    • 18144372419 scopus 로고    scopus 로고
    • Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: Results of thefirst phase i clinical trial
    • Escudier B, et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial. J Transl Med. 2005;3(1):10.
    • (2005) J Transl Med. , vol.3 , Issue.1 , pp. 10
    • Escudier, B.1
  • 38
    • 18144369346 scopus 로고    scopus 로고
    • A phase i study of dexosome immunotherapy in patients with advanced nonsmall cell lung cancer
    • Morse MA, et al. A phase I study of dexosome immunotherapy in patients with advanced nonsmall cell lung cancer. J Transl Med. 2005;3(1):9.
    • (2005) J Transl Med. , vol.3 , Issue.1 , pp. 9
    • Morse, M.A.1
  • 39
    • 84962844515 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC [published online ahead of print February 2, 2016]
    • Besse B, et al. Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC [published online ahead of print February 2, 2016]. Oncoimmunology. doi:10. 1080/2162402X.2015.1071008.
    • Oncoimmunology.
    • Besse, B.1
  • 40
    • 41149172340 scopus 로고    scopus 로고
    • Phase i clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai S, et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther. 2008;16(4):782-790.
    • (2008) Mol Ther. , vol.16 , Issue.4 , pp. 782-790
    • Dai, S.1
  • 41
    • 84855573739 scopus 로고    scopus 로고
    • The roles of tumor-derived exosomes in cancer pathogenesis
    • Yang C, Robbins PD. The roles of tumor-derived exosomes in cancer pathogenesis. Clin Dev Immunol. 2011;2011:842849.
    • (2011) Clin Dev Immunol. , vol.2011 , pp. 842849
    • Yang, C.1    Robbins, P.D.2
  • 42
    • 63449129623 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: A role for NKG2D ligands and IL-15Ralpha
    • Viaud S, et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: A role for NKG2D ligands and IL-15Ralpha. PLoS One. 2009;4(3):e4942.
    • (2009) PLoS One. , vol.4 , Issue.3 , pp. e4942
    • Viaud, S.1
  • 43
    • 54449086268 scopus 로고    scopus 로고
    • Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
    • Simhadri VR, et al. Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function. PLoS One. 2008;3(10):e3377.
    • (2008) PLoS One. , vol.3 , Issue.10 , pp. e3377
    • Simhadri, V.R.1
  • 44
    • 37049037976 scopus 로고    scopus 로고
    • Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
    • Pogge von Strandmann E, et al. Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. Immunity. 2007;27(6):965-974.
    • (2007) Immunity. , vol.27 , Issue.6 , pp. 965-974
    • Pogge Von Strandmann, E.1
  • 45
    • 84875069590 scopus 로고    scopus 로고
    • Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands
    • Munich S, Sobo-Vujanovic A, Buchser WJ, Beer-Stolz D, Vujanovic NL. Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology. 2012;1(7):1074-1083.
    • (2012) Oncoimmunology. , vol.1 , Issue.7 , pp. 1074-1083
    • Munich, S.1    Sobo-Vujanovic, A.2    Buchser, W.J.3    Beer-Stolz, D.4    Vujanovic, N.L.5
  • 46
    • 76749139918 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes for cancer immunotherapy: What's next?
    • Viaud S, et al. Dendritic cell-derived exosomes for cancer immunotherapy: what's next? Cancer Res. 2010;70(4):1281-1285.
    • (2010) Cancer Res. , vol.70 , Issue.4 , pp. 1281-1285
    • Viaud, S.1
  • 47
    • 33644531900 scopus 로고    scopus 로고
    • Chemoimmunotherapy of tumors: Cyclophosphamide synergizes with exosome based vaccines
    • Taieb J, et al. Chemoimmunotherapy of tumors: cyclophosphamide synergizes with exosome based vaccines. J Immunol. 2006;176(5):2722-2729.
    • (2006) J Immunol. , vol.176 , Issue.5 , pp. 2722-2729
    • Taieb, J.1
  • 48
    • 79551514818 scopus 로고    scopus 로고
    • Cyclophosphamide induces differentiation of Th17 cells in cancer patients
    • Viaud S, et al. Cyclophosphamide induces differentiation of Th17 cells in cancer patients. Cancer Res. 2011;71(3):661-665.
    • (2011) Cancer Res. , vol.71 , Issue.3 , pp. 661-665
    • Viaud, S.1
  • 49
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • Viaud S, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013;342(6161):971-976.
    • (2013) Science. , vol.342 , Issue.6161 , pp. 971-976
    • Viaud, S.1
  • 50
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F, et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother. 2007;56(5):641-648.
    • (2007) Cancer Immunol Immunother. , vol.56 , Issue.5 , pp. 641-648
    • Ghiringhelli, F.1
  • 51
    • 84855367971 scopus 로고    scopus 로고
    • Gamma-Interferon-regulated chaperone governs human lymphocyte antigen class II expression
    • Kamper N, Franken S, Temme S, Koch S, Bieber T, Koch N. gamma-Interferon-regulated chaperone governs human lymphocyte antigen class II expression. FASEB J. 2012;26(1):104-116.
    • (2012) FASEB J. , vol.26 , Issue.1 , pp. 104-116
    • Kamper, N.1    Franken, S.2    Temme, S.3    Koch, S.4    Bieber, T.5    Koch, N.6
  • 52
    • 84928811341 scopus 로고    scopus 로고
    • Mutant MHC class II epitopes drive therapeutic immune responses to cancer
    • Kreiter S, et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature. 2015;520(7549):692-696.
    • (2015) Nature. , vol.520 , Issue.7549 , pp. 692-696
    • Kreiter, S.1
  • 53
    • 84928770388 scopus 로고    scopus 로고
    • Neoantigens in cancer immunotherapy
    • Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science. 2015;348(6230):69-74.
    • (2015) Science. , vol.348 , Issue.6230 , pp. 69-74
    • Schumacher, T.N.1    Schreiber, R.D.2
  • 54
    • 38949137056 scopus 로고    scopus 로고
    • Making friends in out-of-theway places: How cells of the immune system get together and how they conduct their business as revealed by intravital imaging
    • Germain RN, et al. Making friends in out-of-theway places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunol Rev. 2008;221:163-181.
    • (2008) Immunol Rev. , vol.221 , pp. 163-181
    • Germain, R.N.1
  • 55
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science. 2011;331(6024):1565-1570.
    • (2011) Science. , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 56
    • 84874903268 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity
    • Naslund TI, Gehrmann U, Qazi KR, Karlsson MC, Gabrielsson S. Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity. J Immunol. 2013;190(6):2712-2719.
    • (2013) J Immunol. , vol.190 , Issue.6 , pp. 2712-2719
    • Naslund, T.I.1    Gehrmann, U.2    Qazi, K.R.3    Karlsson, M.C.4    Gabrielsson, S.5
  • 57
    • 63849165317 scopus 로고    scopus 로고
    • Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism
    • Qazi KR, Gehrmann U, Domange Jordo E, Karlsson MC, Gabrielsson S. Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism. Blood. 2009;113(12):2673-2683.
    • (2009) Blood. , vol.113 , Issue.12 , pp. 2673-2683
    • Qazi, K.R.1    Gehrmann, U.2    Domange Jordo, E.3    Karlsson, M.C.4    Gabrielsson, S.5
  • 59
    • 84899100763 scopus 로고    scopus 로고
    • Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells
    • Sobo-Vujanovic A, Munich S, Vujanovic NL. Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells. Cell Immunol. 2014;289(1-2):119-127.
    • (2014) Cell Immunol. , vol.289 , Issue.1-2 , pp. 119-127
    • Sobo-Vujanovic, A.1    Munich, S.2    Vujanovic, N.L.3
  • 60
    • 84867653559 scopus 로고    scopus 로고
    • Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity
    • Dreux M, et al. Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe. 2012;12(4):558-570.
    • (2012) Cell Host Microbe. , vol.12 , Issue.4 , pp. 558-570
    • Dreux, M.1
  • 61
    • 84911966357 scopus 로고    scopus 로고
    • Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
    • Melo SA, et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell. 2014;26(5):707-721.
    • (2014) Cancer Cell. , vol.26 , Issue.5 , pp. 707-721
    • Melo, S.A.1
  • 62
    • 1642378018 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
    • Ghiringhelli F, et al. CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur J Immunol. 2004;34(2):336-344.
    • (2004) Eur J Immunol. , vol.34 , Issue.2 , pp. 336-344
    • Ghiringhelli, F.1
  • 63
    • 0347626100 scopus 로고    scopus 로고
    • Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model
    • Hermans IF, Chong TW, Palmowski MJ, Harris AL, Cerundolo V. Synergistic effect of metronomic dosing of cyclophosphamide combined with specific antitumor immunotherapy in a murine melanoma model. Cancer Res. 2003;63(23):8408-8413.
    • (2003) Cancer Res. , vol.63 , Issue.23 , pp. 8408-8413
    • Hermans, I.F.1    Chong, T.W.2    Palmowski, M.J.3    Harris, A.L.4    Cerundolo, V.5
  • 64
    • 84902504669 scopus 로고    scopus 로고
    • Trial Watch: Chemotherapy with immunogenic cell death inducers
    • Vacchelli E, et al. Trial Watch: Chemotherapy with immunogenic cell death inducers. Oncoimmunology. 2014;3(1):e27878.
    • (2014) Oncoimmunology. , vol.3 , Issue.1 , pp. e27878
    • Vacchelli, E.1
  • 66
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance
    • Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity. 2013;39(1):74-88.
    • (2013) Immunity. , vol.39 , Issue.1 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 67
    • 79952939196 scopus 로고    scopus 로고
    • IPH-2101, a fully human anti-NK-cell inhibitory receptor mAb for the potential treatment of hematological cancers
    • Alici E. IPH-2101, a fully human anti-NK-cell inhibitory receptor mAb for the potential treatment of hematological cancers. Curr Opin Mol Ther. 2010;12(6):724-733.
    • (2010) Curr Opin Mol Ther. , vol.12 , Issue.6 , pp. 724-733
    • Alici, E.1
  • 68
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
    • Benson DM Jr, et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood. 2011;118(24):6387-6391.
    • (2011) Blood. , vol.118 , Issue.24 , pp. 6387-6391
    • Benson, D.M.1
  • 69
    • 84909620041 scopus 로고    scopus 로고
    • IPH4102, a humanized KIR3DL2 antibody with potent activity against cutaneous T-cell lymphoma
    • Marie-Cardine A, et al. IPH4102, a humanized KIR3DL2 antibody with potent activity against cutaneous T-cell lymphoma. Cancer Res. 2014;74(21):6060-6070.
    • (2014) Cancer Res. , vol.74 , Issue.21 , pp. 6060-6070
    • Marie-Cardine, A.1
  • 70
    • 84928253171 scopus 로고    scopus 로고
    • Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients
    • Semeraro M, et al. Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients. Sci Transl Med. 2015;7(283):283ra55.
    • (2015) Sci Transl Med. , vol.7 , Issue.283 , pp. 283ra55
    • Semeraro, M.1
  • 71
    • 84879100801 scopus 로고    scopus 로고
    • Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors
    • Rusakiewicz S, et al. Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors. Cancer Res. 2013;73(12):3499-3510.
    • (2013) Cancer Res. , vol.73 , Issue.12 , pp. 3499-3510
    • Rusakiewicz, S.1
  • 72
    • 84881229549 scopus 로고    scopus 로고
    • Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: Influence of tumor origin
    • Remark R, et al. Characteristics and clinical impacts of the immune environments in colorectal and renal cell carcinoma lung metastases: influence of tumor origin. Clin Cancer Res. 2013;19(15):4079-4091.
    • (2013) Clin Cancer Res. , vol.19 , Issue.15 , pp. 4079-4091
    • Remark, R.1
  • 73
    • 78049457566 scopus 로고    scopus 로고
    • Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
    • Esser J, et al. Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration. J Allergy Clin Immunol. 2010;126(5):1032-1040.
    • (2010) J Allergy Clin Immunol. , vol.126 , Issue.5 , pp. 1032-1040
    • Esser, J.1
  • 74
    • 33645078915 scopus 로고    scopus 로고
    • Natural killer cell behavior in lymph nodes revealed by static and real-time imaging
    • Bajenoff M, et al. Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. J Exp Med. 2006;203(3):619-631.
    • (2006) J Exp Med. , vol.203 , Issue.3 , pp. 619-631
    • Bajenoff, M.1
  • 75
    • 84892653021 scopus 로고    scopus 로고
    • CD169 mediates the capture of exosomes in spleen and lymph node
    • Saunderson SC, Dunn AC, Crocker PR, McLellan AD. CD169 mediates the capture of exosomes in spleen and lymph node. Blood. 2014;123(2):208-216.
    • (2014) Blood. , vol.123 , Issue.2 , pp. 208-216
    • Saunderson, S.C.1    Dunn, A.C.2    Crocker, P.R.3    McLellan, A.D.4
  • 76
    • 85016490706 scopus 로고    scopus 로고
    • Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
    • Wiklander OP, et al. Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J Extracell Vesicles. 2015;4:26316.
    • (2015) J Extracell Vesicles. , vol.4 , pp. 26316
    • Wiklander, O.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.