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Volumn 377, Issue 1, 2016, Pages 17-24

Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity

Author keywords

Exosomes; Mesenchymal stromal cell; MiR 146a; Multiple myeloma; Notch pathway

Indexed keywords

CXCL1 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MICRORNA 146A; MONOCYTE CHEMOTACTIC PROTEIN 1; NOTCH RECEPTOR; RANTES; CONDITIONED MEDIUM; CYTOKINE; MICRORNA; MIRN146 MICRORNA, HUMAN;

EID: 84963877265     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.04.024     Document Type: Article
Times cited : (124)

References (52)
  • 2
    • 77954564230 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
    • Bergfeld S.A., DeClerck Y.A. Bone marrow-derived mesenchymal stem cells and the tumor microenvironment. Cancer Metastasis Rev 2010, 29:249-261.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 249-261
    • Bergfeld, S.A.1    DeClerck, Y.A.2
  • 3
    • 33845513318 scopus 로고    scopus 로고
    • Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma
    • Arnulf B., Lecourt S., Soulier J., Ternaux B., Lacassagne M.N., Crinquette A., et al. Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma. Leukemia 2007, 21:158-163.
    • (2007) Leukemia , vol.21 , pp. 158-163
    • Arnulf, B.1    Lecourt, S.2    Soulier, J.3    Ternaux, B.4    Lacassagne, M.N.5    Crinquette, A.6
  • 4
    • 84871207138 scopus 로고    scopus 로고
    • Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway
    • Xu S., Evans H., Buckle C., De Veirman K., Hu J., Xu D., et al. Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway. Leukemia 2012, 26:2546-2549.
    • (2012) Leukemia , vol.26 , pp. 2546-2549
    • Xu, S.1    Evans, H.2    Buckle, C.3    De Veirman, K.4    Hu, J.5    Xu, D.6
  • 6
    • 84856015538 scopus 로고    scopus 로고
    • Multiple myeloma mesenchymal stem cells: characterization, origin, and tumor-promoting effects
    • Reagan M.R., Ghobrial I.M. Multiple myeloma mesenchymal stem cells: characterization, origin, and tumor-promoting effects. Clin. Cancer Res 2012, 18:342-349.
    • (2012) Clin. Cancer Res , vol.18 , pp. 342-349
    • Reagan, M.R.1    Ghobrial, I.M.2
  • 7
    • 84901475378 scopus 로고    scopus 로고
    • Microenvironment and multiple myeloma spread
    • Ribatti D., Moschetta M., Vacca A. Microenvironment and multiple myeloma spread. Thromb. Res 2014, 133(Suppl. 2):S102-S106.
    • (2014) Thromb. Res , vol.133 , pp. S102-S106
    • Ribatti, D.1    Moschetta, M.2    Vacca, A.3
  • 8
    • 84896963083 scopus 로고    scopus 로고
    • Kruppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a
    • Wang X., Lu H., Li T., Yu L., Liu G., Peng X., et al. Kruppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a. Am. J. Cancer Res 2013, 3:356-373.
    • (2013) Am. J. Cancer Res , vol.3 , pp. 356-373
    • Wang, X.1    Lu, H.2    Li, T.3    Yu, L.4    Liu, G.5    Peng, X.6
  • 9
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • Roccaro A.M., Sacco A., Maiso P., Azab A.K., Tai Y.T., Reagan M., et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J. Clin. Invest 2013, 123:1542-1555.
    • (2013) J. Clin. Invest , vol.123 , pp. 1542-1555
    • Roccaro, A.M.1    Sacco, A.2    Maiso, P.3    Azab, A.K.4    Tai, Y.T.5    Reagan, M.6
  • 10
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo G., Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol 2013, 200:373-383.
    • (2013) J. Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 11
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: composition, biogenesis and function
    • Thery C., Zitvogel L., Amigorena S. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol 2002, 2:569-579.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 12
    • 84919680938 scopus 로고    scopus 로고
    • Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
    • Umezu T., Tadokoro H., Azuma K., Yoshizawa S., Ohyashiki K., Ohyashiki J.H. Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood 2014, 124:3748-3757.
    • (2014) Blood , vol.124 , pp. 3748-3757
    • Umezu, T.1    Tadokoro, H.2    Azuma, K.3    Yoshizawa, S.4    Ohyashiki, K.5    Ohyashiki, J.H.6
  • 13
    • 84931032854 scopus 로고    scopus 로고
    • Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation
    • Raimondi L., De Luca A., Amodio N., Manno M., Raccosta S., Taverna S., et al. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget 2015, 6:13772-13789.
    • (2015) Oncotarget , vol.6 , pp. 13772-13789
    • Raimondi, L.1    De Luca, A.2    Amodio, N.3    Manno, M.4    Raccosta, S.5    Taverna, S.6
  • 14
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 15
    • 77955722286 scopus 로고    scopus 로고
    • MicroRNAs and metastasis: little RNAs go a long way
    • Dykxhoorn D.M. MicroRNAs and metastasis: little RNAs go a long way. Cancer Res 2010, 70:6401-6406.
    • (2010) Cancer Res , vol.70 , pp. 6401-6406
    • Dykxhoorn, D.M.1
  • 17
    • 77949423427 scopus 로고    scopus 로고
    • Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling
    • Gutierrez N.C., Sarasquete M.E., Misiewicz-Krzeminska I., Delgado M., De Las Rivas J., Ticona F.V., et al. Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling. Leukemia 2010, 24:629-637.
    • (2010) Leukemia , vol.24 , pp. 629-637
    • Gutierrez, N.C.1    Sarasquete, M.E.2    Misiewicz-Krzeminska, I.3    Delgado, M.4    De Las Rivas, J.5    Ticona, F.V.6
  • 19
    • 79956287890 scopus 로고    scopus 로고
    • The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells
    • Guo L., Zhao R.C., Wu Y. The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells. Exp. Hematol 2011, 39:608-616.
    • (2011) Exp. Hematol , vol.39 , pp. 608-616
    • Guo, L.1    Zhao, R.C.2    Wu, Y.3
  • 20
    • 66049138420 scopus 로고    scopus 로고
    • Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells
    • e5605
    • Schoolmeesters A., Eklund T., Leake D., Vermeulen A., Smith Q., Force Aldred S., et al. Functional profiling reveals critical role for miRNA in differentiation of human mesenchymal stem cells. PLoS ONE 2009, 4. e5605.
    • (2009) PLoS ONE , vol.4
    • Schoolmeesters, A.1    Eklund, T.2    Leake, D.3    Vermeulen, A.4    Smith, Q.5    Force Aldred, S.6
  • 21
    • 84892416479 scopus 로고    scopus 로고
    • Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients
    • e79752
    • Xu S., Cecilia Santini G., De Veirman K., Vande Broek I., Leleu X., De Becker A., et al. Upregulation of miR-135b is involved in the impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients. PLoS ONE 2013, 8. e79752.
    • (2013) PLoS ONE , vol.8
    • Xu, S.1    Cecilia Santini, G.2    De Veirman, K.3    Vande Broek, I.4    Leleu, X.5    De Becker, A.6
  • 22
    • 84904868088 scopus 로고    scopus 로고
    • Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells
    • Wang J., Hendrix A., Hernot S., Lemaire M., De Bruyne E., Van Valckenborgh E., et al. Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood 2014, 124:555-566.
    • (2014) Blood , vol.124 , pp. 555-566
    • Wang, J.1    Hendrix, A.2    Hernot, S.3    Lemaire, M.4    De Bruyne, E.5    Van Valckenborgh, E.6
  • 23
    • 84858847737 scopus 로고    scopus 로고
    • The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer
    • Labbaye C., Testa U. The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer. J. Hematol. Oncol 2012, 5:13.
    • (2012) J. Hematol. Oncol , vol.5 , pp. 13
    • Labbaye, C.1    Testa, U.2
  • 24
    • 84911486061 scopus 로고    scopus 로고
    • Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model
    • Reagan M.R., Mishima Y., Glavey S.V., Zhang Y., Manier S., Lu Z.N., et al. Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model. Blood 2014, 124:3250-3259.
    • (2014) Blood , vol.124 , pp. 3250-3259
    • Reagan, M.R.1    Mishima, Y.2    Glavey, S.V.3    Zhang, Y.4    Manier, S.5    Lu, Z.N.6
  • 25
    • 84898742474 scopus 로고    scopus 로고
    • MiR-146a promotes the initiation and progression of melanoma by activating Notch signaling
    • Forloni M., Dogra S.K., Dong Y., Conte D., Ou J., Zhu L.J., et al. miR-146a promotes the initiation and progression of melanoma by activating Notch signaling. Elife 2014, 3:e01460.
    • (2014) Elife , vol.3 , pp. e01460
    • Forloni, M.1    Dogra, S.K.2    Dong, Y.3    Conte, D.4    Ou, J.5    Zhu, L.J.6
  • 26
    • 70349884016 scopus 로고    scopus 로고
    • Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells
    • Perry M.M., Williams A.E., Tsitsiou E., Larner-Svensson H.M., Lindsay M.A. Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett 2009, 583:3349-3355.
    • (2009) FEBS Lett , vol.583 , pp. 3349-3355
    • Perry, M.M.1    Williams, A.E.2    Tsitsiou, E.3    Larner-Svensson, H.M.4    Lindsay, M.A.5
  • 27
    • 84937519093 scopus 로고    scopus 로고
    • Interleukin 1beta-responsive MicroRNA-146a is critical for the cytokine-induced tolerance and cross-tolerance to toll-like receptor ligands
    • Nahid M.A., Satoh M., Chan E.K. Interleukin 1beta-responsive MicroRNA-146a is critical for the cytokine-induced tolerance and cross-tolerance to toll-like receptor ligands. J. Innate Immun 2015, 7:428-440.
    • (2015) J. Innate Immun , vol.7 , pp. 428-440
    • Nahid, M.A.1    Satoh, M.2    Chan, E.K.3
  • 28
    • 0035195019 scopus 로고    scopus 로고
    • Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications
    • Gupta D., Treon S.P., Shima Y., Hideshima T., Podar K., Tai Y.T., et al. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia 2001, 15:1950-1961.
    • (2001) Leukemia , vol.15 , pp. 1950-1961
    • Gupta, D.1    Treon, S.P.2    Shima, Y.3    Hideshima, T.4    Podar, K.5    Tai, Y.T.6
  • 29
    • 0028101292 scopus 로고
    • Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures
    • Lokhorst H.M., Lamme T., de Smet M., Klein S., de Weger R.A., van Oers R., et al. Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures. Blood 1994, 84:2269-2277.
    • (1994) Blood , vol.84 , pp. 2269-2277
    • Lokhorst, H.M.1    Lamme, T.2    de Smet, M.3    Klein, S.4    de Weger, R.A.5    van Oers, R.6
  • 30
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S., Wezeman M.J., Zangari M., Walker R., Cottler-Fox M., Gaddy D., et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006, 91:192-199.
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3    Walker, R.4    Cottler-Fox, M.5    Gaddy, D.6
  • 31
    • 0038446643 scopus 로고    scopus 로고
    • Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma
    • Bisping G., Leo R., Wenning D., Dankbar B., Padro T., Kropff M., et al. Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma. Blood 2003, 101:2775-2783.
    • (2003) Blood , vol.101 , pp. 2775-2783
    • Bisping, G.1    Leo, R.2    Wenning, D.3    Dankbar, B.4    Padro, T.5    Kropff, M.6
  • 32
    • 45849119799 scopus 로고    scopus 로고
    • Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells
    • Zdzisinska B., Bojarska-Junak A., Dmoszynska A., Kandefer-Szerszen M. Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells. Arch. Immunol. Ther. Exp. (Warsz) 2008, 56:207-221.
    • (2008) Arch. Immunol. Ther. Exp. (Warsz) , vol.56 , pp. 207-221
    • Zdzisinska, B.1    Bojarska-Junak, A.2    Dmoszynska, A.3    Kandefer-Szerszen, M.4
  • 33
    • 84900090390 scopus 로고    scopus 로고
    • MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264.7 macrophage cells by inhibiting Notch1
    • He Y., Sun X., Huang C., Long X.R., Lin X., Zhang L., et al. MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264.7 macrophage cells by inhibiting Notch1. Inflammation 2014, 37:71-82.
    • (2014) Inflammation , vol.37 , pp. 71-82
    • He, Y.1    Sun, X.2    Huang, C.3    Long, X.R.4    Lin, X.5    Zhang, L.6
  • 34
    • 84925535914 scopus 로고    scopus 로고
    • Deregulation of NF-small ka, CyrillicB-miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy
    • Yousefzadeh N., Alipour M.R., Soufi F.G. Deregulation of NF-small ka, CyrillicB-miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy. J. Physiol. Biochem 2015, 71:51-58.
    • (2015) J. Physiol. Biochem , vol.71 , pp. 51-58
    • Yousefzadeh, N.1    Alipour, M.R.2    Soufi, F.G.3
  • 35
    • 52149102044 scopus 로고    scopus 로고
    • Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells
    • Bhaumik D., Scott G.K., Schokrpur S., Patil C.K., Campisi J., Benz C.C. Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 2008, 27:5643-5647.
    • (2008) Oncogene , vol.27 , pp. 5643-5647
    • Bhaumik, D.1    Scott, G.K.2    Schokrpur, S.3    Patil, C.K.4    Campisi, J.5    Benz, C.C.6
  • 36
    • 84925679176 scopus 로고    scopus 로고
    • Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals
    • Dalbeth N., Pool B., Shaw O.M., Harper J.L., Tan P., Franklin C., et al. Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals. Ann. Rheum. Dis 2015, 74:786-790.
    • (2015) Ann. Rheum. Dis , vol.74 , pp. 786-790
    • Dalbeth, N.1    Pool, B.2    Shaw, O.M.3    Harper, J.L.4    Tan, P.5    Franklin, C.6
  • 37
    • 84892709897 scopus 로고    scopus 로고
    • Upregulation of microRNA-146a was not accompanied by downregulation of pro-inflammatory markers in diabetic kidney
    • Alipour M.R., Khamaneh A.M., Yousefzadeh N., Mohammad-nejad D., Soufi F.G. Upregulation of microRNA-146a was not accompanied by downregulation of pro-inflammatory markers in diabetic kidney. Mol. Biol. Rep 2013, 40:6477-6483.
    • (2013) Mol. Biol. Rep , vol.40 , pp. 6477-6483
    • Alipour, M.R.1    Khamaneh, A.M.2    Yousefzadeh, N.3    Mohammad-nejad, D.4    Soufi, F.G.5
  • 38
    • 66549106493 scopus 로고    scopus 로고
    • The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
    • Sprynski A.C., Hose D., Caillot L., Reme T., Shaughnessy J.D., Barlogie B., et al. The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. Blood 2009, 113:4614-4626.
    • (2009) Blood , vol.113 , pp. 4614-4626
    • Sprynski, A.C.1    Hose, D.2    Caillot, L.3    Reme, T.4    Shaughnessy, J.D.5    Barlogie, B.6
  • 39
    • 84929590465 scopus 로고    scopus 로고
    • Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3
    • Zhu S., Wang Z., Li Z., Peng H., Luo Y., Deng M., et al. Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3. Oncotarget 2015, 6:10460-10472.
    • (2015) Oncotarget , vol.6 , pp. 10460-10472
    • Zhu, S.1    Wang, Z.2    Li, Z.3    Peng, H.4    Luo, Y.5    Deng, M.6
  • 40
    • 0037262287 scopus 로고    scopus 로고
    • Expression and function of chemokine receptors in human multiple myeloma
    • Moller C., Stromberg T., Juremalm M., Nilsson K., Nilsson G. Expression and function of chemokine receptors in human multiple myeloma. Leukemia 2003, 17:203-210.
    • (2003) Leukemia , vol.17 , pp. 203-210
    • Moller, C.1    Stromberg, T.2    Juremalm, M.3    Nilsson, K.4    Nilsson, G.5
  • 41
    • 34948896045 scopus 로고    scopus 로고
    • Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    • Karnoub A.E., Dash A.B., Vo A.P., Sullivan A., Brooks M.W., Bell G.W., et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007, 449:557-563.
    • (2007) Nature , vol.449 , pp. 557-563
    • Karnoub, A.E.1    Dash, A.B.2    Vo, A.P.3    Sullivan, A.4    Brooks, M.W.5    Bell, G.W.6
  • 42
    • 84907971363 scopus 로고    scopus 로고
    • Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease
    • Garcia-Gomez A., De Las Rivas J., Ocio E.M., Diaz-Rodriguez E., Montero J.C., Martin M., et al. Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease. Oncotarget 2014, 5:8284-8305.
    • (2014) Oncotarget , vol.5 , pp. 8284-8305
    • Garcia-Gomez, A.1    De Las Rivas, J.2    Ocio, E.M.3    Diaz-Rodriguez, E.4    Montero, J.C.5    Martin, M.6
  • 43
    • 84952942820 scopus 로고    scopus 로고
    • The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells
    • Wang J., De Veirman K., De Beule N., Maes K., De Bruyne E., Van Valckenborgh E., et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget 2015, 6:43992-44004.
    • (2015) Oncotarget , vol.6 , pp. 43992-44004
    • Wang, J.1    De Veirman, K.2    De Beule, N.3    Maes, K.4    De Bruyne, E.5    Van Valckenborgh, E.6
  • 44
    • 84945157600 scopus 로고    scopus 로고
    • Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p
    • Ding G., Zhou L., Qian Y., Fu M., Chen J., Xiang J., et al. Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p. Oncotarget 2015, 6:29877-29888.
    • (2015) Oncotarget , vol.6 , pp. 29877-29888
    • Ding, G.1    Zhou, L.2    Qian, Y.3    Fu, M.4    Chen, J.5    Xiang, J.6
  • 45
    • 84886625070 scopus 로고    scopus 로고
    • Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity
    • Munoz J.L., Bliss S.A., Greco S.J., Ramkissoon S.H., Ligon K.L., Rameshwar P. Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity. Mol. Ther. Nucleic Acids 2013, 2:e126.
    • (2013) Mol. Ther. Nucleic Acids , vol.2 , pp. e126
    • Munoz, J.L.1    Bliss, S.A.2    Greco, S.J.3    Ramkissoon, S.H.4    Ligon, K.L.5    Rameshwar, P.6
  • 46
    • 84964217310 scopus 로고    scopus 로고
    • Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt's lymphoma exosomes
    • Yoon C., Kim J., Park G., Kim S., Kim D., Hur D.Y., et al. Delivery of miR-155 to retinal pigment epithelial cells mediated by Burkitt's lymphoma exosomes. Tumor Biol 2015.
    • (2015) Tumor Biol
    • Yoon, C.1    Kim, J.2    Park, G.3    Kim, S.4    Kim, D.5    Hur, D.Y.6
  • 47
    • 84875675102 scopus 로고    scopus 로고
    • MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells
    • Zhong T., Perelman J.M., Kolosov V.P., Zhou X.D. MiR-146a negatively regulates neutrophil elastase-induced MUC5AC secretion from 16HBE human bronchial epithelial cells. Mol. Cell. Biochem 2011, 358:249-255.
    • (2011) Mol. Cell. Biochem , vol.358 , pp. 249-255
    • Zhong, T.1    Perelman, J.M.2    Kolosov, V.P.3    Zhou, X.D.4
  • 48
    • 84857154347 scopus 로고    scopus 로고
    • MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state
    • e30832
    • Saba R., Gushue S., Huzarewich R.L., Manguiat K., Medina S., Robertson C., et al. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. PLoS ONE 2012, 7. e30832.
    • (2012) PLoS ONE , vol.7
    • Saba, R.1    Gushue, S.2    Huzarewich, R.L.3    Manguiat, K.4    Medina, S.5    Robertson, C.6
  • 49
    • 37549037911 scopus 로고    scopus 로고
    • Off the beaten pathway: the complex cross talk between Notch and NF-kappaB
    • Osipo C., Golde T.E., Osborne B.A., Miele L.A. Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Lab. Invest 2008, 88:11-17.
    • (2008) Lab. Invest , vol.88 , pp. 11-17
    • Osipo, C.1    Golde, T.E.2    Osborne, B.A.3    Miele, L.A.4
  • 51
    • 34047243994 scopus 로고    scopus 로고
    • Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis
    • Kondoh K., Sunadome K., Nishida E. Notch signaling suppresses p38 MAPK activity via induction of MKP-1 in myogenesis. J. Biol. Chem 2007, 282:3058-3065.
    • (2007) J. Biol. Chem , vol.282 , pp. 3058-3065
    • Kondoh, K.1    Sunadome, K.2    Nishida, E.3
  • 52
    • 57149092998 scopus 로고    scopus 로고
    • Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb
    • Kuang W., Tan J., Duan Y., Duan J., Wang W., Jin F., et al. Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb. Biochem. Biophys. Res. Commun 2009, 378:259-263.
    • (2009) Biochem. Biophys. Res. Commun , vol.378 , pp. 259-263
    • Kuang, W.1    Tan, J.2    Duan, Y.3    Duan, J.4    Wang, W.5    Jin, F.6


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