Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells

Journal of Cancer Research and Clinical Oncology

Volumn 133, Issue 6, 2007, Pages 389-399

  Yang, Yunshan ^a,b   Xiu, Fangming ^a   Cai, Zhijian ^a   Wang, Jianli ^a   Wang, Qingqing ^a   Fu, Yangxin ^a   Cao, Xuetao ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cancer vaccine; CTL; Exosomes; Immunotherapy; Interleukin 2

Indexed keywords

INTERLEUKIN 2;

ANIMAL CELL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOSOME; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; MOLECULAR MODEL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL; VACCINATION; WESTERN BLOTTING;

ANIMALS; CANCER VACCINES; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; INTERLEUKIN-2; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; OVALBUMIN; T-LYMPHOCYTES; THYMOMA; TRANSFECTION; TRANSPORT VESICLES;

EID: 34248141586     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-006-0184-7     Document Type: Article

References (34)

1. Atkins MB, Regan M, McDermott D (2004) Update on the role of interleukin 2 and other cytokines in the treatment of patients with stage IV renal carcinoma. Clin Cancer Res 10(18):6342S-6346S
2. Bykovskaja SN, Buffo MJ, Bunker M, Zhang H, Majors A, Herbert M, Lokshin A, Levitt ML, Jaja A, Scalise D, Kosiban D, Evans C, Marks S, Shogan J (1998) Interleukin-2-induces development of denditric cells from cord blood CD34+ cells. J Leukoc Biol 63:620-630
3. Cao X, Zhang W, He L, Xie Z, Ma S, Tao Q, Yu Y, Hamada H, Wang J (1998) Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity. J Immunol 161:6238-6244
4. Cao X, Zhang W, Wan T, Yu Y, Wang J (1999a) Enhanced antitumor immune responses of IL-2 gene-modified tumor vaccine by combination with IL-1 and low dose cyclophosphamide. J Exp Clin Cancer Res 18(2):173-179
5. Cao X, Wang Q, Ju D, Tao Q, Wang J (1999b) Efficient induction of local and systemic antitumor immune response by liposome-mediated intratumoral co-transfer of interleukin-2 gene and interleukin-6 gene. J Exp Clin Cancer Res 18(2):191-199
6. Chaput N, Schartz NE, Andre F, Taieb J, Novault S, Bonnaventure P, Aubert N, Bernard J, Lemonnier F, Merad M, Adema G, Adams M, Ferrantini M, Carpentier AF, Escudier B, Tursz T, Angevin E, Zitvogel L (2004) Exosomes as potent cell-free peptide-based vaccine. II. Exosomes in CpG ODN adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection. J Immunol 172:2137-2146
7. Dai S, Wan T, Wang B, Zhou X, Xiu F, Chen T, Wu Y, Cao X (2005) More efficient induction of HLA-A*0201-restricted and CEA-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumour cells. Clin Cancer Res 11(20):7554-7563
8. Eklund JW, Kuzel TM (2005) Interleukin-2 in the treatment of renal cell carcinoma and malignant melanoma. Cancer Treat Res 126:263-287
9. Escudier B, Dorval T, Chaput N, Andre F, Caby MP, Novault S, Flament C, Leboulaire C, Borg C, Amigorena S, Boccaccio C, Bonnerot C, Dhellin O, Movassagh M, Piperno S, Robert C, Serra V, Valente N, Le Pecq JB, Spatz A, Lantz O, Tursz T, Angevin E, Zitvogel L (2005) Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med 3(1):10
10. Fukao T, Koyasu S (2000) Expression of functional IL-2 receptors on mature splenic dendritic cells. Eur J Immunol 30:1453-1457
11. Gastpar R, Gehrmann M, Bausero MA, Asea A, Gross C, Schroeder JA, Multhoff G (2005) Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res 65(12):5238-5247
12. Granucci F, Andrews DM, Degli-Esposti MA, Ricciardi-Castagnoli P (2002) IL-2 mediates adjuvant effect of dendritic cells. Trends Immunol 23:169-171
13. Hsu DH, Paz P, Villaflor G, Rivas A, Mehta-Damani A, Angevin E, Zitvogel L, Le Pecq JB (2003) Exosomes as a tumor vaccine: enhancing potency through direct loading of antigenic peptides. J Immunother 26:440-450
14. Johnston D, Reynolds SR, Bystryn JC (2005) Interleukin-2/liposomes potentiate immune responses to a soluble protein cancer vaccine in mice. Cancer Immunol Immunother 54(9):1-8
15. Li D, Ronson B, Guo M, Liu S, Bishop JS, Van Echo DA, O'Malley BW Jr (2002) Interleukin 2 gene transfer prevents NKG2D suppression and enhances antitumor efficacy in combination with cisplatin for head and neck squamous cell cancer. Cancer Res 62:4023-4028
16. Massa C, Melani C, Colombo MP (2005) Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens. Cancer Res 65(17):7942-7949
17. Morelli AE, Larregina AT, Shufesky WJ, Sullivan ML, Stolz DB, Papworth GD, Zahorchak AF, Logar AJ, Wang Z, Watkins SC, Falo LD Jr, Thomson AW (2004) Endocytosis, intracellular sorting and processing of exosomes by dendritic cells. Blood 104:3257-3266
18. Morse MA, Garst J, Osada T, Khan S, Hobeika A, Clay TM, Valente N, Shreeniwas R, Sutton MA, Delcayre A, Hsu DH, Le Pecq JB, Lyerly HK (2005) A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med 3(1):9
19. Overwijk WW, Theoret MR, Restifo NP (2000) The future of interleukin-2: enhancing therapeutic anticancer vaccines. Cancer J Sci Am 6(Suppl 1):S76-S80
20. Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, Melief CJ, Geuze HJ (1996) B lymphocytes secrete antigen-presenting vesicles. J Exp Med 183(3):1161-1172
21. Shimizu K, Fields RC, Giedlin M, Mule JJ (1999) Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines. Proc Natl Acad Sci USA 96:2268-2273
22. Shurin MR, Lu L, Kalinski P, Stewart-Akers AM, Lotze MT (1999) Th1/Th2 balance in cancer, transplantation and pregnancy. Springer Semin Immunopathol 21(3):339-359
23. Taieb J, Chaput N, Zitvogel L (2005) Dendritic cell-derived exosomes as cell-free peptide-based vaccines. Crit Rev Immunol 25(3):215-223
24. Thery C, Zitvogel L, Amigorena S (2002a) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2:569-579
25. Thery C, Duban L, Segura E, Veron P, Lantz O, Amigorena S (2002b) Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat Immunol 3(12):1156-1162
26. Tsan MF, Gao B (2004) Cytokine function of heat shock proteins. Am J Physiol Cell Physiol 286(4):C739-C744
27. Wan T, Zhou X, Chen G, An H, Chen T, Zhang W, Liu S, Jiang Y, Yang F, Wu Y, Cao X (2005) Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Blood 103(5):1747-1754
28. Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, Masurier C, Flament C, Pouzieux S, Faure F, Tursz T, Angevin E, Amigorena S, Zitvogel L (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 7:297-303
29. Wu Y, Wan T, Zhou X, Wang B, Yang F, Li N, Chen G, Dai S, Liu S, Zhang M, Cao X (2005) Hsp70-like protein 1 fusion protein enhances induction of carcinoembryonic antigen-specific CD8+ CTL response by dendritic cell vaccine. Cancer Res 65(11):4947-4954
30. Xia D, Zhang W, Zheng S, Wang J, Pan JP, Wang Q, Zhang LH, Hamada H, Cao X (2002) Lymphotactin cotransfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100. Gene Ther 9(9):592-601
31. Xiu F, Cao X (2004) Exosomes in the immune response and tolerance. J Microbiol Immunol 2(4):231-236
32. Xiu F, Yang Y, Cai Z, Wang J, Cao X (2004) Isolation and characterization of exosomes derived from tumor cells genetically expressing model antigen. J Microbiol Immunol 2(4):278-285
33. Yu P, Fu Y (2006) Tumor-infiltrating T lymphocytes: friends or foes? Lab Invest 86(3):231-245
34. Zitvogel L, Regnault A, Lozier A, Wolfers J, Flament C, Tenza D, Ricciardi-Castagnoli P, Raposo G, Amigorena S (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 4:594-600