Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203

Cellular Immunology

Volumn 292, Issue 1-2, 2014, Pages 65-69

  Zhou, Min ^a   Chen, Jionghuang ^a   Zhou, Liangjing ^a   Chen, Wenchao ^a   Ding, Guoping ^a   Cao, Liping ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Dendritic cells; Exosomes; MicroRNAs; Pancreatic cancer; Toll like receptor

Indexed keywords

INTERLEUKIN 12; MESSENGER RNA; MICRORNA; MICRORNA 203; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MIRN203 MICRORNA, HUMAN; TLR4 PROTEIN, HUMAN;

ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DENDRITIC CELL; EXOSOME; HUMAN; HUMAN CELL; PANCREAS CANCER; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; PANCREAS TUMOR; TUMOR CELL LINE;

CELL LINE, TUMOR; DENDRITIC CELLS; EXOSOMES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-12; MICRORNAS; PANCREATIC NEOPLASMS; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84908312386     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2014.09.004     Document Type: Article

References (27)

1. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116(2):281-297.
2. He L., Thomson J.M., Hemann M.T., Hernando-Monge E., Mu D., Goodson S., et al. A microRNA polycistron as a potential human oncogene. Nature 2005, 435(7043):828-833.
3. Fais S., Logozzi M., Lugini L., Federici C., Azzarito T., Zarovni N., et al. Exosomes: the ideal nanovectors for biodelivery. Biol. Chem. 2013, 394(1):1-15.
4. Bobrie A., Colombo M., Raposo G., Thery C. Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 2011, 12(12):1659-1668.
5. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001, 1(2):135-145.
6. Okamoto M., Oshikawa T., Tano T., Ahmed S.U., Kan S., Sasai A., et al. Mechanism of anticancer host response induced by OK-432, a streptococcal preparation, mediated by phagocytosis and toll-like receptor 4 signaling. J. Immunother. 2006, 29(1):78-86.
7. Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat. Rev. Immunol. 2004, 4(12):941-952.
8. Termeer C., Benedix F., Sleeman J., Fieber C., Voith U., Ahrens T., et al. Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4. J. Exp. Med. 2002, 195(1):99-111.
9. Szafranska A.E., Davison T.S., John J., Cannon T., Sipos B., Maghnouj A., et al. MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene 2007, 26(30):4442-4452.
10. Greither T., Grochola L.F., Udelnow A., Lautenschlager C., Wurl P., Taubert H. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int. J. Cancer 2010, 126(1):73-80.
11. C. Thery, S. Amigorena, G. Raposo, A, Clayton. Isolation and characterization of exosomes from cell culture supernatants and biological fluids, Current protocols in cell biology/editorial board, Juan S Bonifacino et al., 2006; Chapter 3:Unit 3.22.
12. Kroh E.M., Parkin R.K., Mitchell P.S., Tewari M. Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 2010, 50(4):298-301.
13. Zhu L., Qu X.H., Sun Y.L., Qian Y.M., Zhao X.H. Novel method for extracting exosomes of hepatocellular carcinoma cells. WJG World J. Gastroenterol. 2014, 20(21):6651-6657.
14. Street J.M., Barran P.E., Mackay C.L., Weidt S., Balmforth C., Walsh T.S., et al. Identification and proteomic profiling of exosomes in human cerebrospinal fluid. J. Transl. Med. 2012, 10:5.
15. Cameron J.L., Riall T.S., Coleman J., Belcher K.A. One thousand consecutive pancreaticoduodenectomies. Ann. Surg. 2006, 244(1):10-15.
16. Bloomston M., Frankel W.L., Petrocca F., Volinia S., Alder H., Hagan J.P., et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA J. Am. Med. Assoc. 2007, 297(17):1901-1908.
17. Ikenaga N., Ohuchida K., Mizumoto K., Yu J., Kayashima T., Sakai H., et al. MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma. Ann. Surg. Oncol. 2010, 17(12):3120-3128.
18. Segura E., Nicco C., Lombard B., Veron P., Raposo G., Batteux F., et al. ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood 2005, 106(1):216-223.
19. Andreola G., Rivoltini L., Castelli C., Huber V., Perego P., Deho P., et al. Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 2002, 195(10):1303-1316.
20. Valenti R., Huber V., Filipazzi P., Pilla L., Sovena G., Villa A., et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res. 2006, 66(18):9290-9298.
21. Kogure T., Lin W.L., Yan I.K., Braconi C., Patel T. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology 2011, 54(4):1237-1248.
22. Ohshima K., Inoue K., Fujiwara A., Hatakeyama K., Kanto K., Watanabe Y., et al. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One 2010, 5(10):e13247.
23. Fabbri M., Paone A., Calore F., Galli R., Gaudio E., Santhanam R., et al. MicroRNAs bind to toll-like receptors to induce prometastatic inflammatory response. Proc. Natl. Acad. Sci. U.S.A. 2012, 109(31):E2110-E2116.
24. Quinn S.R., O'Neill L.A. A trio of microRNAs that control toll-like receptor signalling. Int. Immunol. 2011, 23(7):421-425.
25. Sun Y., Cai J., Ma F., Lu P., Huang H., Zhou J. MiR-155 mediates suppressive effect of progesterone on TLR3, TLR4-triggered immune response. Immunol. Lett. 2012, 146(1-2):25-30.
26. Huang B., Zhao J., Unkeless J.C., Feng Z.H., Xiong H. TLR signaling by tumor and immune cells: a double-edged sword. Oncogene 2008, 27(2):218-224.
27. Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4(7):499-511.