메뉴 건너뛰기




Volumn 6, Issue 8, 2011, Pages

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; MESSENGER RNA; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR ANTIGEN;

EID: 79960984966     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022517     Document Type: Article
Times cited : (109)

References (57)
  • 1
    • 0042470540 scopus 로고    scopus 로고
    • Does the immune system see tumors as foreign or self?
    • Pardoll D, (2003) Does the immune system see tumors as foreign or self? Annu Rev Immunol 21: 807-839.
    • (2003) Annu Rev Immunol , vol.21 , pp. 807-839
    • Pardoll, D.1
  • 2
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W, (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 5: 263-274.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 3
    • 41149119143 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    • Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V, (2008) Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol Rev 222: 162-179.
    • (2008) Immunol Rev , vol.222 , pp. 162-179
    • Marigo, I.1    Dolcetti, L.2    Serafini, P.3    Zanovello, P.4    Bronte, V.5
  • 4
    • 0033991158 scopus 로고    scopus 로고
    • Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance
    • Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S, (2000) Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol 74: 181-273.
    • (2000) Adv Immunol , vol.74 , pp. 181-273
    • Marincola, F.M.1    Jaffee, E.M.2    Hicklin, D.J.3    Ferrone, S.4
  • 5
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Thery C, Ostrowski M, Segura E, (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9: 581-593.
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Thery, C.1    Ostrowski, M.2    Segura, E.3
  • 6
    • 70350593773 scopus 로고    scopus 로고
    • Exosomes in tumour immunity
    • Clayton A, Mason MD, (2009) Exosomes in tumour immunity. Curr Oncol 16: 46-49.
    • (2009) Curr Oncol , vol.16 , pp. 46-49
    • Clayton, A.1    Mason, M.D.2
  • 7
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ, (2000) Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 113 Pt 19: 3365-3374.
    • (2000) J Cell Sci , vol.113 , Issue.Pt 19 , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3    Stoorvogel, W.4    Geuze, H.J.5
  • 8
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: composition, biogenesis and function
    • Thery C, Zitvogel L, Amigorena S, (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2: 569-579.
    • (2002) Nat Rev Immunol , vol.2 , pp. 569-579
    • Thery, C.1    Zitvogel, L.2    Amigorena, S.3
  • 10
    • 0037183242 scopus 로고    scopus 로고
    • Malignant effusions and immunogenic tumour-derived exosomes
    • Andre F, Schartz NE, Movassagh M, Flament C, Pautier P, et al. (2002) Malignant effusions and immunogenic tumour-derived exosomes. Lancet 360: 295-305.
    • (2002) Lancet , vol.360 , pp. 295-305
    • Andre, F.1    Schartz, N.E.2    Movassagh, M.3    Flament, C.4    Pautier, P.5
  • 11
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers J, Lozier A, Raposo G, Regnault A, Thery C, et al. (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 7: 297-303.
    • (2001) Nat Med , vol.7 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3    Regnault, A.4    Thery, C.5
  • 12
    • 27144529107 scopus 로고    scopus 로고
    • More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    • Dai S, Wan T, Wang B, Zhou X, Xiu F, et al. (2005) More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin Cancer Res 11: 7554-7563.
    • (2005) Clin Cancer Res , vol.11 , pp. 7554-7563
    • Dai, S.1    Wan, T.2    Wang, B.3    Zhou, X.4    Xiu, F.5
  • 13
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2
    • Clayton A, Mitchell JP, Court J, Mason MD, Tabi Z, (2007) Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Cancer Res 67: 7458-7466.
    • (2007) Cancer Res , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 14
    • 24644445037 scopus 로고    scopus 로고
    • Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial
    • Navabi H, Croston D, Hobot J, Clayton A, Zitvogel L, et al. (2005) Preparation of human ovarian cancer ascites-derived exosomes for a clinical trial. Blood Cells Mol Dis 35: 149-152.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 149-152
    • Navabi, H.1    Croston, D.2    Hobot, J.3    Clayton, A.4    Zitvogel, L.5
  • 15
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • Dai S, Wei D, Wu Z, Zhou X, Wei X, et al. (2008) Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther 16: 782-790.
    • (2008) Mol Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5
  • 16
    • 34447549680 scopus 로고    scopus 로고
    • Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells
    • Dai S, Zhou X, Wang B, Wang Q, Fu Y, et al. (2006) Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. J Mol Med 84: 1067-1076.
    • (2006) J Mol Med , vol.84 , pp. 1067-1076
    • Dai, S.1    Zhou, X.2    Wang, B.3    Wang, Q.4    Fu, Y.5
  • 17
    • 34248141586 scopus 로고    scopus 로고
    • Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells
    • Yang Y, Xiu F, Cai Z, Wang J, Wang Q, et al. (2007) Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells. J Cancer Res Clin Oncol 133: 389-399.
    • (2007) J Cancer Res Clin Oncol , vol.133 , pp. 389-399
    • Yang, Y.1    Xiu, F.2    Cai, Z.3    Wang, J.4    Wang, Q.5
  • 18
    • 74549132676 scopus 로고    scopus 로고
    • Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma
    • Zhang Y, Luo CL, He BC, Zhang JM, Cheng G, et al. (2010) Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma. Int J Oncol 36: 133-140.
    • (2010) Int J Oncol , vol.36 , pp. 133-140
    • Zhang, Y.1    Luo, C.L.2    He, B.C.3    Zhang, J.M.4    Cheng, G.5
  • 19
    • 33745362875 scopus 로고    scopus 로고
    • Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells
    • Chen W, Wang J, Shao C, Liu S, Yu Y, et al. (2006) Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol 36: 1598-1607.
    • (2006) Eur J Immunol , vol.36 , pp. 1598-1607
    • Chen, W.1    Wang, J.2    Shao, C.3    Liu, S.4    Yu, Y.5
  • 20
    • 34247898904 scopus 로고    scopus 로고
    • Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes
    • Xiu F, Cai Z, Yang Y, Wang X, Wang J, et al. (2007) Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes. J Mol Med 85: 511-521.
    • (2007) J Mol Med , vol.85 , pp. 511-521
    • Xiu, F.1    Cai, Z.2    Yang, Y.3    Wang, X.4    Wang, J.5
  • 21
    • 39449101177 scopus 로고    scopus 로고
    • Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    • Zeelenberg IS, Ostrowski M, Krumeich S, Bobrie A, Jancic C, et al. (2008) Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res 68: 1228-1235.
    • (2008) Cancer Res , vol.68 , pp. 1228-1235
    • Zeelenberg, I.S.1    Ostrowski, M.2    Krumeich, S.3    Bobrie, A.4    Jancic, C.5
  • 22
    • 0242525678 scopus 로고    scopus 로고
    • T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors
    • Taylor DD, Gercel-Taylor C, Lyons KS, Stanson J, Whiteside TL, (2003) T-cell apoptosis and suppression of T-cell receptor/CD3-zeta by Fas ligand-containing membrane vesicles shed from ovarian tumors. Clin Cancer Res 9: 5113-5119.
    • (2003) Clin Cancer Res , vol.9 , pp. 5113-5119
    • Taylor, D.D.1    Gercel-Taylor, C.2    Lyons, K.S.3    Stanson, J.4    Whiteside, T.L.5
  • 23
    • 14844334129 scopus 로고    scopus 로고
    • Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects
    • Taylor DD, Gercel-Taylor C, (2005) Tumour-derived exosomes and their role in cancer-associated T-cell signalling defects. Br J Cancer 92: 305-311.
    • (2005) Br J Cancer , vol.92 , pp. 305-311
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 24
    • 18844376919 scopus 로고    scopus 로고
    • Exosomes and the MICA-NKG2D system in cancer
    • Clayton A, Tabi Z, (2005) Exosomes and the MICA-NKG2D system in cancer. Blood Cells Mol Dis 34: 206-213.
    • (2005) Blood Cells Mol Dis , vol.34 , pp. 206-213
    • Clayton, A.1    Tabi, Z.2
  • 25
    • 47249144117 scopus 로고    scopus 로고
    • Human tumor-derived exosomes down-modulate NKG2D expression
    • Clayton A, Mitchell JP, Court J, Linnane S, Mason MD, et al. (2008) Human tumor-derived exosomes down-modulate NKG2D expression. J Immunol 180: 7249-7258.
    • (2008) J Immunol , vol.180 , pp. 7249-7258
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Linnane, S.4    Mason, M.D.5
  • 26
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu C, Yu S, Zinn K, Wang J, Zhang L, et al. (2006) Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J Immunol 176: 1375-1385.
    • (2006) J Immunol , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3    Wang, J.4    Zhang, L.5
  • 27
    • 34249792918 scopus 로고    scopus 로고
    • Tumor exosomes inhibit differentiation of bone marrow dendritic cells
    • Yu S, Liu C, Su K, Wang J, Liu Y, et al. (2007) Tumor exosomes inhibit differentiation of bone marrow dendritic cells. J Immunol 178: 6867-6875.
    • (2007) J Immunol , vol.178 , pp. 6867-6875
    • Yu, S.1    Liu, C.2    Su, K.3    Wang, J.4    Liu, Y.5
  • 28
    • 33749488765 scopus 로고    scopus 로고
    • Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes
    • Valenti R, Huber V, Filipazzi P, Pilla L, Sovena G, et al. (2006) Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res 66: 9290-9298.
    • (2006) Cancer Res , vol.66 , pp. 9290-9298
    • Valenti, R.1    Huber, V.2    Filipazzi, P.3    Pilla, L.4    Sovena, G.5
  • 29
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik M, Czystowska M, Szczepanski MJ, Mandapathil M, Whiteside TL, (2010) Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One 5: e11469.
    • (2010) PLoS One , vol.5
    • Szajnik, M.1    Czystowska, M.2    Szczepanski, M.J.3    Mandapathil, M.4    Whiteside, T.L.5
  • 30
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, et al. (2010) Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 120: 457-471.
    • (2010) J Clin Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4    Bruchard, M.5
  • 31
    • 63649092087 scopus 로고    scopus 로고
    • Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes
    • Keller S, Konig AK, Marme F, Runz S, Wolterink S, et al. (2009) Systemic presence and tumor-growth promoting effect of ovarian carcinoma released exosomes. Cancer Lett 278: 73-81.
    • (2009) Cancer Lett , vol.278 , pp. 73-81
    • Keller, S.1    Konig, A.K.2    Marme, F.3    Runz, S.4    Wolterink, S.5
  • 32
    • 33745424807 scopus 로고    scopus 로고
    • Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model
    • Peche H, Renaudin K, Beriou G, Merieau E, Amigorena S, et al. (2006) Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model. Am J Transplant 6: 1541-1550.
    • (2006) Am J Transplant , vol.6 , pp. 1541-1550
    • Peche, H.1    Renaudin, K.2    Beriou, G.3    Merieau, E.4    Amigorena, S.5
  • 34
    • 34848861342 scopus 로고    scopus 로고
    • MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner
    • Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD, (2007) MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J Immunol 179: 2235-2241.
    • (2007) J Immunol , vol.179 , pp. 2235-2241
    • Kim, S.H.1    Bianco, N.R.2    Shufesky, W.J.3    Morelli, A.E.4    Robbins, P.D.5
  • 35
    • 28244488762 scopus 로고    scopus 로고
    • Tolerosome-induced oral tolerance is MHC dependent
    • Ostman S, Taube M, Telemo E, (2005) Tolerosome-induced oral tolerance is MHC dependent. Immunology 116: 464-476.
    • (2005) Immunology , vol.116 , pp. 464-476
    • Ostman, S.1    Taube, M.2    Telemo, E.3
  • 36
    • 49049116385 scopus 로고    scopus 로고
    • Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction
    • Prado N, Marazuela EG, Segura E, Fernandez-Garcia H, Villalba M, et al. (2008) Exosomes from bronchoalveolar fluid of tolerized mice prevent allergic reaction. J Immunol 181: 1519-1525.
    • (2008) J Immunol , vol.181 , pp. 1519-1525
    • Prado, N.1    Marazuela, E.G.2    Segura, E.3    Fernandez-Garcia, H.4    Villalba, M.5
  • 37
    • 0032515968 scopus 로고    scopus 로고
    • Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects
    • Ghivizzani SC, Lechman ER, Kang R, Tio C, Kolls J, et al. (1998) Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci U S A 95: 4613-4618.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 4613-4618
    • Ghivizzani, S.C.1    Lechman, E.R.2    Kang, R.3    Tio, C.4    Kolls, J.5
  • 38
    • 0033566812 scopus 로고    scopus 로고
    • Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees
    • Lechman ER, Jaffurs D, Ghivizzani SC, Gambotto A, Kovesdi I, et al. (1999) Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 163: 2202-2208.
    • (1999) J Immunol , vol.163 , pp. 2202-2208
    • Lechman, E.R.1    Jaffurs, D.2    Ghivizzani, S.C.3    Gambotto, A.4    Kovesdi, I.5
  • 39
    • 0034469484 scopus 로고    scopus 로고
    • Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4
    • Kim SH, Evans CH, Kim S, Oligino T, Ghivizzani SC, et al. (2000) Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4. Arthritis Res 2: 293-302.
    • (2000) Arthritis Res , vol.2 , pp. 293-302
    • Kim, S.H.1    Evans, C.H.2    Kim, S.3    Oligino, T.4    Ghivizzani, S.C.5
  • 40
    • 0242693291 scopus 로고    scopus 로고
    • The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen
    • Lechman ER, Keravala A, Nash J, Kim SH, Mi Z, et al. (2003) The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen. Gene Ther 10: 2029-2035.
    • (2003) Gene Ther , vol.10 , pp. 2029-2035
    • Lechman, E.R.1    Keravala, A.2    Nash, J.3    Kim, S.H.4    Mi, Z.5
  • 41
    • 0032505870 scopus 로고    scopus 로고
    • NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
    • Miagkov AV, Kovalenko DV, Brown CE, Didsbury JR, Cogswell JP, et al. (1998) NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci U S A 95: 13859-13864.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13859-13864
    • Miagkov, A.V.1    Kovalenko, D.V.2    Brown, C.E.3    Didsbury, J.R.4    Cogswell, J.P.5
  • 42
    • 30344460536 scopus 로고    scopus 로고
    • Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive
    • Kim SH, Bianco N, Menon R, Lechman ER, Shufesky WJ, et al. (2006) Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther 13: 289-300.
    • (2006) Mol Ther , vol.13 , pp. 289-300
    • Kim, S.H.1    Bianco, N.2    Menon, R.3    Lechman, E.R.4    Shufesky, W.J.5
  • 43
    • 34848915428 scopus 로고    scopus 로고
    • Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4
    • Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD, (2007) Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol 179: 2242-2249.
    • (2007) J Immunol , vol.179 , pp. 2242-2249
    • Kim, S.H.1    Bianco, N.R.2    Shufesky, W.J.3    Morelli, A.E.4    Robbins, P.D.5
  • 44
    • 20844458756 scopus 로고    scopus 로고
    • Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis
    • Kim SH, Lechman ER, Bianco N, Menon R, Keravala A, et al. (2005) Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol 174: 6440-6448.
    • (2005) J Immunol , vol.174 , pp. 6440-6448
    • Kim, S.H.1    Lechman, E.R.2    Bianco, N.3    Menon, R.4    Keravala, A.5
  • 45
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-5153.
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5
  • 46
    • 0026763193 scopus 로고
    • Transforming growth factor-beta 1 inhibits murine immediate and delayed type hypersensitivity
    • Meade R, Askenase PW, Geba GP, Neddermann K, Jacoby RO, et al. (1992) Transforming growth factor-beta 1 inhibits murine immediate and delayed type hypersensitivity. J Immunol 149: 521-528.
    • (1992) J Immunol , vol.149 , pp. 521-528
    • Meade, R.1    Askenase, P.W.2    Geba, G.P.3    Neddermann, K.4    Jacoby, R.O.5
  • 47
    • 0032030582 scopus 로고    scopus 로고
    • A novel role for TGF-beta and IL-10 in the induction of immune privilege
    • D'Orazio TJ, Niederkorn JY, (1998) A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol 160: 2089-2098.
    • (1998) J Immunol , vol.160 , pp. 2089-2098
    • D'Orazio, T.J.1    Niederkorn, J.Y.2
  • 48
    • 1642465408 scopus 로고    scopus 로고
    • IL-4 from Th2-type cells suppresses induction of delayed-type hypersensitivity elicited shortly after immunization
    • Jacysyn JF, Abrahamsohn IA, Macedo MS, (2003) IL-4 from Th2-type cells suppresses induction of delayed-type hypersensitivity elicited shortly after immunization. Immunol Cell Biol 81: 424-430.
    • (2003) Immunol Cell Biol , vol.81 , pp. 424-430
    • Jacysyn, J.F.1    Abrahamsohn, I.A.2    Macedo, M.S.3
  • 49
    • 0032526354 scopus 로고    scopus 로고
    • Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production
    • Seder RA, Marth T, Sieve MC, Strober W, Letterio JJ, et al. (1998) Factors involved in the differentiation of TGF-beta-producing cells from naive CD4+ T cells: IL-4 and IFN-gamma have opposing effects, while TGF-beta positively regulates its own production. J Immunol 160: 5719-5728.
    • (1998) J Immunol , vol.160 , pp. 5719-5728
    • Seder, R.A.1    Marth, T.2    Sieve, M.C.3    Strober, W.4    Letterio, J.J.5
  • 50
    • 33845653262 scopus 로고    scopus 로고
    • The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma
    • Cone RE, Li X, Sharafieh R, O'Rourke J, Vella AT, (2007) The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma. Immunology 120: 112-119.
    • (2007) Immunology , vol.120 , pp. 112-119
    • Cone, R.E.1    Li, X.2    Sharafieh, R.3    O'Rourke, J.4    Vella, A.T.5
  • 51
    • 0029887715 scopus 로고    scopus 로고
    • Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway
    • Rock KL, Clark K, (1996) Analysis of the role of MHC class II presentation in the stimulation of cytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHC class I presentation pathway. J Immunol 156: 3721-3726.
    • (1996) J Immunol , vol.156 , pp. 3721-3726
    • Rock, K.L.1    Clark, K.2
  • 52
    • 34247607233 scopus 로고    scopus 로고
    • T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells
    • Mallegol J, Van Niel G, Lebreton C, Lepelletier Y, Candalh C, et al. (2007) T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. Gastroenterology 132: 1866-1876.
    • (2007) Gastroenterology , vol.132 , pp. 1866-1876
    • Mallegol, J.1    van Niel, G.2    Lebreton, C.3    Lepelletier, Y.4    Candalh, C.5
  • 53
    • 79957879331 scopus 로고    scopus 로고
    • Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
    • Hood JL, San RS, Wickline SA, (2011) Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res 71: 3792-3801.
    • (2011) Cancer Res , vol.71 , pp. 3792-3801
    • Hood, J.L.1    San, R.S.2    Wickline, S.A.3
  • 54
    • 0035668081 scopus 로고    scopus 로고
    • Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages
    • Whalen JD, Thomson AW, Lu L, Robbins PD, Evans CH, (2001) Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: evidence for involvement of genetically modified dendritic cells and macrophages. Mol Ther 4: 543-550.
    • (2001) Mol Ther , vol.4 , pp. 543-550
    • Whalen, J.D.1    Thomson, A.W.2    Lu, L.3    Robbins, P.D.4    Evans, C.H.5
  • 55
    • 0345103410 scopus 로고    scopus 로고
    • Systemic characteristics of chronic arthritis induced by transfer of human rheumatoid synovial membrane into SCID mice (human/murine SCID arthritis)
    • Sack U, Gunther A, Pfeiffer R, Genest M, Kinne J, et al. (1999) Systemic characteristics of chronic arthritis induced by transfer of human rheumatoid synovial membrane into SCID mice (human/murine SCID arthritis). J Autoimmun 13: 335-346.
    • (1999) J Autoimmun , vol.13 , pp. 335-346
    • Sack, U.1    Gunther, A.2    Pfeiffer, R.3    Genest, M.4    Kinne, J.5
  • 56
    • 0023821578 scopus 로고
    • Introduction of soluble protein into the class I pathway of antigen processing and presentation
    • Moore MW, Carbone FR, Bevan MJ, (1988) Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54: 777-785.
    • (1988) Cell , vol.54 , pp. 777-785
    • Moore, M.W.1    Carbone, F.R.2    Bevan, M.J.3
  • 57
    • 0028998709 scopus 로고
    • Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity
    • Falo LD Jr, Kovacsovics-Bankowski M, Thompson K, Rock KL, (1995) Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity. Nat Med 1: 649-653.
    • (1995) Nat Med , vol.1 , pp. 649-653
    • Falo Jr., L.D.1    Kovacsovics-Bankowski, M.2    Thompson, K.3    Rock, K.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.