-
1
-
-
0028004195
-
Is the bitter rejection response always adaptive?
-
Glendinning, J. I. Is the bitter rejection response always adaptive?. Physiol. Behav. 1994, 56, 1217-1227, 10.1016/0031-9384(94)90369-7
-
(1994)
Physiol. Behav.
, vol.56
, pp. 1217-1227
-
-
Glendinning, J.I.1
-
2
-
-
0034677653
-
A novel family of mammalian taste receptors
-
Adler, E.; Hoon, M. A.; Mueller, K. L.; Chandrashekar, J.; Ryba, N. J.; Zuker, C. S. A novel family of mammalian taste receptors. Cell 2000, 100, 693-702, 10.1016/S0092-8674(00)80705-9
-
(2000)
Cell
, vol.100
, pp. 693-702
-
-
Adler, E.1
Hoon, M.A.2
Mueller, K.L.3
Chandrashekar, J.4
Ryba, N.J.5
Zuker, C.S.6
-
3
-
-
0034677655
-
T2Rs function as bitter taste receptors
-
Chandrashekar, J.; Mueller, K. L.; Hoon, M. A.; Adler, E.; Feng, L.; Guo, W.; Zuker, C. S.; Ryba, N. J. T2Rs function as bitter taste receptors. Cell 2000, 100, 703-711, 10.1016/S0092-8674(00)80706-0
-
(2000)
Cell
, vol.100
, pp. 703-711
-
-
Chandrashekar, J.1
Mueller, K.L.2
Hoon, M.A.3
Adler, E.4
Feng, L.5
Guo, W.6
Zuker, C.S.7
Ryba, N.J.8
-
4
-
-
0034611738
-
A family of candidate taste receptors in human and mouse
-
Matsunami, H.; Montmayeur, J. P.; Buck, L. B. A family of candidate taste receptors in human and mouse. Nature 2000, 404, 601-604, 10.1038/35007072
-
(2000)
Nature
, vol.404
, pp. 601-604
-
-
Matsunami, H.1
Montmayeur, J.P.2
Buck, L.B.3
-
5
-
-
0036844351
-
The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
-
Bufe, B.; Hofmann, T.; Krautwurst, D.; Raguse, J. D.; Meyerhof, W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat. Genet. 2002, 32, 397-401, 10.1038/ng1014
-
(2002)
Nat. Genet.
, vol.32
, pp. 397-401
-
-
Bufe, B.1
Hofmann, T.2
Krautwurst, D.3
Raguse, J.D.4
Meyerhof, W.5
-
6
-
-
77953892833
-
Oligomerization of TAS2R bitter taste receptors
-
Kuhn, C.; Bufe, B.; Batram, C.; Meyerhof, W. Oligomerization of TAS2R bitter taste receptors. Chem. Senses 2010, 35, 395-406, 10.1093/chemse/bjq027
-
(2010)
Chem. Senses
, vol.35
, pp. 395-406
-
-
Kuhn, C.1
Bufe, B.2
Batram, C.3
Meyerhof, W.4
-
7
-
-
2642511376
-
The human taste receptor hTAS2R14 responds to a variety of different bitter compounds
-
Behrens, M.; Brockhoff, A.; Kuhn, C.; Bufe, B.; Winnig, M.; Meyerhof, W. The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem. Biophys. Res. Commun. 2004, 319, 479-485, 10.1016/j.bbrc.2004.05.019
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.319
, pp. 479-485
-
-
Behrens, M.1
Brockhoff, A.2
Kuhn, C.3
Bufe, B.4
Winnig, M.5
Meyerhof, W.6
-
8
-
-
77950114281
-
The molecular receptive ranges of human TAS2R bitter taste receptors
-
Meyerhof, W.; Batram, C.; Kuhn, C.; Brockhoff, A.; Chudoba, E.; Bufe, B.; Appendino, G.; Behrens, M. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 2010, 35, 157-170, 10.1093/chemse/bjp092
-
(2010)
Chem. Senses
, vol.35
, pp. 157-170
-
-
Meyerhof, W.1
Batram, C.2
Kuhn, C.3
Brockhoff, A.4
Chudoba, E.5
Bufe, B.6
Appendino, G.7
Behrens, M.8
-
9
-
-
84878451181
-
Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol
-
Thalmann, S.; Behrens, M.; Meyerhof, W. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Biochem. Biophys. Res. Commun. 2013, 435, 267-273, 10.1016/j.bbrc.2013.04.066
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.435
, pp. 267-273
-
-
Thalmann, S.1
Behrens, M.2
Meyerhof, W.3
-
10
-
-
13944250257
-
The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
-
Bufe, B.; Breslin, P. A.; Kuhn, C.; Reed, D. R.; Tharp, C. D.; Slack, J. P.; Kim, U. K.; Drayna, D.; Meyerhof, W. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr. Biol. 2005, 15, 322-327, 10.1016/j.cub.2005.01.047
-
(2005)
Curr. Biol.
, vol.15
, pp. 322-327
-
-
Bufe, B.1
Breslin, P.A.2
Kuhn, C.3
Reed, D.R.4
Tharp, C.D.5
Slack, J.P.6
Kim, U.K.7
Drayna, D.8
Meyerhof, W.9
-
11
-
-
24344435450
-
Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci
-
Kim, U.; Wooding, S.; Ricci, D.; Jorde, L. B.; Drayna, D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum. Mutat. 2005, 26, 199-204, 10.1002/humu.20203
-
(2005)
Hum. Mutat.
, vol.26
, pp. 199-204
-
-
Kim, U.1
Wooding, S.2
Ricci, D.3
Jorde, L.B.4
Drayna, D.5
-
12
-
-
1842539589
-
Natural selection and molecular evolution in PTC, a bitter-taste receptor gene
-
Wooding, S.; Kim, U. K.; Bamshad, M. J.; Larsen, J.; Jorde, L. B.; Drayna, D. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am. J. Hum. Genet. 2004, 74, 637-646, 10.1086/383092
-
(2004)
Am. J. Hum. Genet.
, vol.74
, pp. 637-646
-
-
Wooding, S.1
Kim, U.K.2
Bamshad, M.J.3
Larsen, J.4
Jorde, L.B.5
Drayna, D.6
-
13
-
-
58049095069
-
Bitter taste receptors influence glucose homeostasis
-
Dotson, C. D.; Zhang, L.; Xu, H.; Shin, Y. K.; Vigues, S.; Ott, S. H.; Elson, A. E.; Choi, H. J.; Shaw, H.; Egan, J. M.; Mitchell, B. D.; Li, X.; Steinle, N. I.; Munger, S. D. Bitter taste receptors influence glucose homeostasis. PLoS One 2008, 3, e3974, 10.1371/journal.pone.0003974
-
(2008)
PLoS One
, vol.3
, pp. e3974
-
-
Dotson, C.D.1
Zhang, L.2
Xu, H.3
Shin, Y.K.4
Vigues, S.5
Ott, S.H.6
Elson, A.E.7
Choi, H.J.8
Shaw, H.9
Egan, J.M.10
Mitchell, B.D.11
Li, X.12
Steinle, N.I.13
Munger, S.D.14
-
14
-
-
0037458815
-
Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
-
Kim, U. K.; Jorgenson, E.; Coon, H.; Leppert, M.; Risch, N.; Drayna, D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003, 299, 1221-1225, 10.1126/science.1080190
-
(2003)
Science
, vol.299
, pp. 1221-1225
-
-
Kim, U.K.1
Jorgenson, E.2
Coon, H.3
Leppert, M.4
Risch, N.5
Drayna, D.6
-
15
-
-
34547858150
-
Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin
-
Pronin, A. N.; Xu, H.; Tang, H.; Zhang, L.; Li, Q.; Li, X. Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr. Biol. 2007, 17, 1403-1408, 10.1016/j.cub.2007.07.046
-
(2007)
Curr. Biol.
, vol.17
, pp. 1403-1408
-
-
Pronin, A.N.1
Xu, H.2
Tang, H.3
Zhang, L.4
Li, Q.5
Li, X.6
-
16
-
-
84943564180
-
Receptor polymorphism and genomic structure interact to shape bitter taste perception
-
Roudnitzky, N.; Behrens, M.; Engel, A.; Kohl, S.; Thalmann, S.; Hubner, S.; Lossow, K.; Wooding, S. P.; Meyerhof, W. Receptor polymorphism and genomic structure interact to shape bitter taste perception. PLoS Genet. 2015, 11, e1005530, 10.1371/journal.pgen.1005530
-
(2015)
PLoS Genet.
, vol.11
, pp. e1005530
-
-
Roudnitzky, N.1
Behrens, M.2
Engel, A.3
Kohl, S.4
Thalmann, S.5
Hubner, S.6
Lossow, K.7
Wooding, S.P.8
Meyerhof, W.9
-
17
-
-
80051700826
-
Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners
-
Roudnitzky, N.; Bufe, B.; Thalmann, S.; Kuhn, C.; Gunn, H. C.; Xing, C.; Crider, B. P.; Behrens, M.; Meyerhof, W.; Wooding, S. P. Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners. Hum. Mol. Genet. 2011, 20, 3437-3449, 10.1093/hmg/ddr252
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 3437-3449
-
-
Roudnitzky, N.1
Bufe, B.2
Thalmann, S.3
Kuhn, C.4
Gunn, H.C.5
Xing, C.6
Crider, B.P.7
Behrens, M.8
Meyerhof, W.9
Wooding, S.P.10
-
18
-
-
84991039884
-
Copy number variation in TAS2R bitter taste receptor genes: Structure, origin, and population genetics
-
Roudnitzky, N.; Risso, D.; Drayna, D.; Behrens, M.; Meyerhof, W.; Wooding, S. P. Copy number variation in TAS2R bitter taste receptor genes: structure, origin, and population genetics. Chem. Senses 2016, 41, 649-659, 10.1093/chemse/bjw067
-
(2016)
Chem. Senses
, vol.41
, pp. 649-659
-
-
Roudnitzky, N.1
Risso, D.2
Drayna, D.3
Behrens, M.4
Meyerhof, W.5
Wooding, S.P.6
-
19
-
-
22744443058
-
Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16
-
Soranzo, N.; Bufe, B.; Sabeti, P. C.; Wilson, J. F.; Weale, M. E.; Marguerie, R.; Meyerhof, W.; Goldstein, D. B. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr. Biol. 2005, 15, 1257-1265, 10.1016/j.cub.2005.06.042
-
(2005)
Curr. Biol.
, vol.15
, pp. 1257-1265
-
-
Soranzo, N.1
Bufe, B.2
Sabeti, P.C.3
Wilson, J.F.4
Weale, M.E.5
Marguerie, R.6
Meyerhof, W.7
Goldstein, D.B.8
-
20
-
-
33748474661
-
Variability in a taste-receptor gene determines whether we taste toxins in food
-
Sandell, M. A.; Breslin, P. A. Variability in a taste-receptor gene determines whether we taste toxins in food. Curr. Biol. 2006, 16, R792-R794, 10.1016/j.cub.2006.08.049
-
(2006)
Curr. Biol.
, vol.16
, pp. R792-R794
-
-
Sandell, M.A.1
Breslin, P.A.2
-
21
-
-
84868610108
-
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
-
Lee, R. J.; Xiong, G.; Kofonow, J. M.; Chen, B.; Lysenko, A.; Jiang, P.; Abraham, V.; Doghramji, L.; Adappa, N. D.; Palmer, J. N.; Kennedy, D. W.; Beauchamp, G. K.; Doulias, P. T.; Ischiropoulos, H.; Kreindler, J. L.; Reed, D. R.; Cohen, N. A. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J. Clin. Invest. 2012, 122, 4145-4159, 10.1172/JCI64240
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 4145-4159
-
-
Lee, R.J.1
Xiong, G.2
Kofonow, J.M.3
Chen, B.4
Lysenko, A.5
Jiang, P.6
Abraham, V.7
Doghramji, L.8
Adappa, N.D.9
Palmer, J.N.10
Kennedy, D.W.11
Beauchamp, G.K.12
Doulias, P.T.13
Ischiropoulos, H.14
Kreindler, J.L.15
Reed, D.R.16
Cohen, N.A.17
-
22
-
-
84893042536
-
Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa
-
Campbell, M. C.; Ranciaro, A.; Zinshteyn, D.; Rawlings-Goss, R.; Hirbo, J.; Thompson, S.; Woldemeskel, D.; Froment, A.; Rucker, J. B.; Omar, S. A.; Bodo, J. M.; Nyambo, T.; Belay, G.; Drayna, D.; Breslin, P. A.; Tishkoff, S. A. Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa. Mol. Biol. Evol. 2014, 31, 288-302, 10.1093/molbev/mst211
-
(2014)
Mol. Biol. Evol.
, vol.31
, pp. 288-302
-
-
Campbell, M.C.1
Ranciaro, A.2
Zinshteyn, D.3
Rawlings-Goss, R.4
Hirbo, J.5
Thompson, S.6
Woldemeskel, D.7
Froment, A.8
Rucker, J.B.9
Omar, S.A.10
Bodo, J.M.11
Nyambo, T.12
Belay, G.13
Drayna, D.14
Breslin, P.A.15
Tishkoff, S.A.16
-
23
-
-
84914153160
-
Bitter and sweet taste receptors in the respiratory epithelium in health and disease
-
Lee, R. J.; Cohen, N. A. Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J. Mol. Med. (Heidelberg, Ger.) 2014, 92, 1235-1244, 10.1007/s00109-014-1222-6
-
(2014)
J. Mol. Med. (Heidelberg, Ger.)
, vol.92
, pp. 1235-1244
-
-
Lee, R.J.1
Cohen, N.A.2
-
24
-
-
84875615895
-
Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs
-
Behrens, M.; Meyerhof, W. Bitter taste receptor research comes of age: from characterization to modulation of TAS2Rs. Semin. Cell Dev. Biol. 2013, 24, 215-221, 10.1016/j.semcdb.2012.08.006
-
(2013)
Semin. Cell Dev. Biol.
, vol.24
, pp. 215-221
-
-
Behrens, M.1
Meyerhof, W.2
-
25
-
-
84951743686
-
Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios
-
Di Pizio, A.; Levit, A.; Slutzki, M.; Behrens, M.; Karaman, R.; Niv, M. Y. Comparing Class A GPCRs to bitter taste receptors: structural motifs, ligand interactions and agonist-to-antagonist ratios. Methods Cell Biol. 2016, 132, 401-427, 10.1016/bs.mcb.2015.10.005
-
(2016)
Methods Cell Biol.
, vol.132
, pp. 401-427
-
-
Di Pizio, A.1
Levit, A.2
Slutzki, M.3
Behrens, M.4
Karaman, R.5
Niv, M.Y.6
-
26
-
-
84870232467
-
Recent advances in structure and function studies on human bitter taste receptors
-
Pydi, S. P.; Upadhyaya, J.; Singh, N.; Pal Bhullar, R.; Chelikani, P. Recent advances in structure and function studies on human bitter taste receptors. Curr. Protein Pept. Sci. 2012, 13, 501-508, 10.2174/138920312803582942
-
(2012)
Curr. Protein Pept. Sci.
, vol.13
, pp. 501-508
-
-
Pydi, S.P.1
Upadhyaya, J.2
Singh, N.3
Pal Bhullar, R.4
Chelikani, P.5
-
27
-
-
77954653331
-
Structural requirements of bitter taste receptor activation
-
Brockhoff, A.; Behrens, M.; Niv, M. Y.; Meyerhof, W. Structural requirements of bitter taste receptor activation. Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 11110-11115, 10.1073/pnas.0913862107
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 11110-11115
-
-
Brockhoff, A.1
Behrens, M.2
Niv, M.Y.3
Meyerhof, W.4
-
28
-
-
84941145251
-
Evidence for a transient additional ligand binding site in the TAS2R46 bitter taste receptor
-
Sandal, M.; Behrens, M.; Brockhoff, A.; Musiani, F.; Giorgetti, A.; Carloni, P.; Meyerhof, W. Evidence for a transient additional ligand binding site in the TAS2R46 bitter taste receptor. J. Chem. Theory Comput. 2015, 11, 4439-4449, 10.1021/acs.jctc.5b00472
-
(2015)
J. Chem. Theory Comput.
, vol.11
, pp. 4439-4449
-
-
Sandal, M.1
Behrens, M.2
Brockhoff, A.3
Musiani, F.4
Giorgetti, A.5
Carloni, P.6
Meyerhof, W.7
-
29
-
-
84871753673
-
The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands
-
Born, S.; Levit, A.; Niv, M. Y.; Meyerhof, W.; Behrens, M. The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J. Neurosci. 2013, 33, 201-213, 10.1523/JNEUROSCI.3248-12.2013
-
(2013)
J. Neurosci.
, vol.33
, pp. 201-213
-
-
Born, S.1
Levit, A.2
Niv, M.Y.3
Meyerhof, W.4
Behrens, M.5
-
30
-
-
77956243395
-
Characterization of the beta- d -glucopyranoside binding site of the human bitter taste receptor hTAS2R16
-
Sakurai, T.; Misaka, T.; Ishiguro, M.; Masuda, K.; Sugawara, T.; Ito, K.; Kobayashi, T.; Matsuo, S.; Ishimaru, Y.; Asakura, T.; Abe, K. Characterization of the beta- d -glucopyranoside binding site of the human bitter taste receptor hTAS2R16. J. Biol. Chem. 2010, 285, 28373-28378, 10.1074/jbc.M110.144444
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 28373-28378
-
-
Sakurai, T.1
Misaka, T.2
Ishiguro, M.3
Masuda, K.4
Sugawara, T.5
Ito, K.6
Kobayashi, T.7
Matsuo, S.8
Ishimaru, Y.9
Asakura, T.10
Abe, K.11
-
31
-
-
84878530705
-
Coarse-grained/molecular mechanics of the TAS2R38 bitter taste receptor: Experimentally-validated detailed structural prediction of agonist binding
-
Marchiori, A.; Capece, L.; Giorgetti, A.; Gasparini, P.; Behrens, M.; Carloni, P.; Meyerhof, W. Coarse-grained/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally-validated detailed structural prediction of agonist binding. PLoS One 2013, 8, e64675, 10.1371/journal.pone.0064675
-
(2013)
PLoS One
, vol.8
, pp. e64675
-
-
Marchiori, A.1
Capece, L.2
Giorgetti, A.3
Gasparini, P.4
Behrens, M.5
Carloni, P.6
Meyerhof, W.7
-
32
-
-
84906987340
-
Amino acid derivatives as bitter taste receptor (T2R) blockers
-
Pydi, S. P.; Sobotkiewicz, T.; Billakanti, R.; Bhullar, R. P.; Loewen, M. C.; Chelikani, P. Amino acid derivatives as bitter taste receptor (T2R) blockers. J. Biol. Chem. 2014, 289, 25054-25066, 10.1074/jbc.M114.576975
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 25054-25066
-
-
Pydi, S.P.1
Sobotkiewicz, T.2
Billakanti, R.3
Bhullar, R.P.4
Loewen, M.C.5
Chelikani, P.6
-
33
-
-
8544242989
-
Identification of ligands for two human bitter T2R receptors
-
Pronin, A. N.; Tang, H.; Connor, J.; Keung, W. Identification of ligands for two human bitter T2R receptors. Chem. Senses 2004, 29, 583-593, 10.1093/chemse/bjh064
-
(2004)
Chem. Senses
, vol.29
, pp. 583-593
-
-
Pronin, A.N.1
Tang, H.2
Connor, J.3
Keung, W.4
-
34
-
-
58449104836
-
Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates
-
Grus, W. E.; Zhang, J. Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates. Mol. Biol. Evol. 2009, 26, 407-419, 10.1093/molbev/msn262
-
(2009)
Mol. Biol. Evol.
, vol.26
, pp. 407-419
-
-
Grus, W.E.1
Zhang, J.2
-
35
-
-
84922843655
-
Molecular evidence for the loss of three basic tastes in penguins
-
Zhao, H.; Li, J.; Zhang, J. Molecular evidence for the loss of three basic tastes in penguins. Curr. Biol. 2015, 25, R141-142, 10.1016/j.cub.2015.01.026
-
(2015)
Curr. Biol.
, vol.25
, pp. R141-R142
-
-
Zhao, H.1
Li, J.2
Zhang, J.3
-
36
-
-
84902978738
-
Massive losses of taste receptor genes in toothed and baleen whales
-
Feng, P.; Zheng, J.; Rossiter, S. J.; Wang, D.; Zhao, H. Massive losses of taste receptor genes in toothed and baleen whales. Genome Biol. Evol. 2014, 6, 1254-1265, 10.1093/gbe/evu095
-
(2014)
Genome Biol. Evol.
, vol.6
, pp. 1254-1265
-
-
Feng, P.1
Zheng, J.2
Rossiter, S.J.3
Wang, D.4
Zhao, H.5
-
37
-
-
84859450268
-
Major taste loss in carnivorous mammals
-
Jiang, P.; Josue, J.; Li, X.; Glaser, D.; Li, W.; Brand, J. G.; Margolskee, R. F.; Reed, D. R.; Beauchamp, G. K. Major taste loss in carnivorous mammals. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 4956-4961, 10.1073/pnas.1118360109
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 4956-4961
-
-
Jiang, P.1
Josue, J.2
Li, X.3
Glaser, D.4
Li, W.5
Brand, J.G.6
Margolskee, R.F.7
Reed, D.R.8
Beauchamp, G.K.9
-
38
-
-
84957933898
-
Aquatic adaptation and the evolution of smell and taste in whales
-
Kishida, T.; Thewissen, J.; Hayakawa, T.; Imai, H.; Agata, K. Aquatic adaptation and the evolution of smell and taste in whales. Zoological Lett. 2015, 1, 9, 10.1186/s40851-014-0002-z
-
(2015)
Zoological Lett.
, vol.1
, pp. 9
-
-
Kishida, T.1
Thewissen, J.2
Hayakawa, T.3
Imai, H.4
Agata, K.5
-
39
-
-
84976493239
-
Dietary specialization drives multiple independent losses and gains in the bitter taste gene repertoire of Laurasiatherian mammals
-
Liu, Z.; Liu, G.; Hailer, F.; Orozco-terWengel, P.; Tan, X.; Tian, J.; Yan, Z.; Zhang, B.; Li, M. Dietary specialization drives multiple independent losses and gains in the bitter taste gene repertoire of Laurasiatherian mammals. Front. Zool. 2016, 13, 28, 10.1186/s12983-016-0161-1
-
(2016)
Front. Zool.
, vol.13
, pp. 28
-
-
Liu, Z.1
Liu, G.2
Hailer, F.3
Orozco-TerWengel, P.4
Tan, X.5
Tian, J.6
Yan, Z.7
Zhang, B.8
Li, M.9
-
40
-
-
84964313013
-
The loss of taste genes in cetaceans
-
Zhu, K.; Zhou, X.; Xu, S.; Sun, D.; Ren, W.; Zhou, K.; Yang, G. The loss of taste genes in cetaceans. BMC Evol. Biol. 2014, 14, 218, 10.1186/s12862-014-0218-8
-
(2014)
BMC Evol. Biol.
, vol.14
, pp. 218
-
-
Zhu, K.1
Zhou, X.2
Xu, S.3
Sun, D.4
Ren, W.5
Zhou, K.6
Yang, G.7
-
41
-
-
0038708520
-
Adaptive diversification of bitter taste receptor genes in mammalian evolution
-
Shi, P.; Zhang, J.; Yang, H.; Zhang, Y. P. Adaptive diversification of bitter taste receptor genes in mammalian evolution. Mol. Biol. Evol. 2003, 20, 805-814, 10.1093/molbev/msg083
-
(2003)
Mol. Biol. Evol.
, vol.20
, pp. 805-814
-
-
Shi, P.1
Zhang, J.2
Yang, H.3
Zhang, Y.P.4
-
42
-
-
84905819213
-
Positive Darwinian selection in the singularly large taste receptor gene family of an 'ancient' fish, Latimeria chalumnae
-
Syed, A. S.; Korsching, S. I. Positive Darwinian selection in the singularly large taste receptor gene family of an 'ancient' fish, Latimeria chalumnae. BMC Genomics 2014, 15, 650, 10.1186/1471-2164-15-650
-
(2014)
BMC Genomics
, vol.15
, pp. 650
-
-
Syed, A.S.1
Korsching, S.I.2
-
43
-
-
84877287787
-
An evolutionary perspective on food and human taste
-
Breslin, P. A. An evolutionary perspective on food and human taste. Curr. Biol. 2013, 23, R409-R418, 10.1016/j.cub.2013.04.010
-
(2013)
Curr. Biol.
, vol.23
, pp. R409-R418
-
-
Breslin, P.A.1
-
44
-
-
0034962717
-
The science and complexity of bitter taste
-
Drewnowski, A. The science and complexity of bitter taste. Nutr. Rev. 2001, 59, 163-169, 10.1111/j.1753-4887.2001.tb07007.x
-
(2001)
Nutr. Rev.
, vol.59
, pp. 163-169
-
-
Drewnowski, A.1
-
46
-
-
84892383736
-
Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores
-
Hu, L. L.; Shi, P. Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores. Zool. Res. 2013, 34, E75-E81, 10.11813/j.issn.0254-5853.2013.E3.E75
-
(2013)
Zool. Res.
, vol.34
, pp. E75-E81
-
-
Hu, L.L.1
Shi, P.2
-
47
-
-
84893051272
-
Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire
-
Li, D.; Zhang, J. Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol. Biol. Evol. 2014, 31, 303-309, 10.1093/molbev/mst219
-
(2014)
Mol. Biol. Evol.
, vol.31
, pp. 303-309
-
-
Li, D.1
Zhang, J.2
-
48
-
-
0001151773
-
Strategies in herbivory by mammals: The role of plant secondary compounds
-
Freeland, W. J.; Janzen, D. H. Strategies in herbivory by mammals: the role of plant secondary compounds. Am. Nat. 1974, 108, 269-289, 10.1086/282907
-
(1974)
Am. Nat.
, vol.108
, pp. 269-289
-
-
Freeland, W.J.1
Janzen, D.H.2
-
49
-
-
0028034115
-
Use of Vernonia amygdalina by wild chimpanzee: Possible roles of its bitter and related constituents
-
Koshimizu, K.; Ohigashi, H.; Huffman, M. A. Use of Vernonia amygdalina by wild chimpanzee: possible roles of its bitter and related constituents. Physiol. Behav. 1994, 56, 1209-1216, 10.1016/0031-9384(94)90368-9
-
(1994)
Physiol. Behav.
, vol.56
, pp. 1209-1216
-
-
Koshimizu, K.1
Ohigashi, H.2
Huffman, M.A.3
-
50
-
-
84903641121
-
Ruminant self-medication against gastrointestinal nematodes: Evidence, mechanism, and origins
-
Villalba, J. J.; Miller, J.; Ungar, E. D.; Landau, S. Y.; Glendinning, J. Ruminant self-medication against gastrointestinal nematodes: evidence, mechanism, and origins. Parasite 2014, 21, 31, 10.1051/parasite/2014032
-
(2014)
Parasite
, vol.21
, pp. 31
-
-
Villalba, J.J.1
Miller, J.2
Ungar, E.D.3
Landau, S.Y.4
Glendinning, J.5
-
51
-
-
36248977649
-
Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells
-
Behrens, M.; Foerster, S.; Staehler, F.; Raguse, J. D.; Meyerhof, W. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J. Neurosci. 2007, 27, 12630-12640, 10.1523/JNEUROSCI.1168-07.2007
-
(2007)
J. Neurosci.
, vol.27
, pp. 12630-12640
-
-
Behrens, M.1
Foerster, S.2
Staehler, F.3
Raguse, J.D.4
Meyerhof, W.5
-
52
-
-
84959518053
-
The bitter truth about bitter taste receptors: Beyond sensing bitter in the oral cavity
-
Avau, B.; Depoortere, I. The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity. Acta Physiol. 2016, 216, 407-420, 10.1111/apha.12621
-
(2016)
Acta Physiol.
, vol.216
, pp. 407-420
-
-
Avau, B.1
Depoortere, I.2
-
53
-
-
85027576434
-
-
Springer: Berlin, Germanyp, DOI: 10.1007/7355-2014-79
-
Behrens, M.; Prandi, S.; Meyerhof, W. Taste Receptor Gene Expression Outside the Gustatory System; Springer: Berlin, Germany, 2014; pp 1-34, DOI: 10.1007/7355-2014-79.
-
(2014)
Taste Receptor Gene Expression Outside the Gustatory System
, pp. 1-34
-
-
Behrens, M.1
Prandi, S.2
Meyerhof, W.3
-
54
-
-
84880839367
-
Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model
-
Ansoleaga, B.; Garcia-Esparcia, P.; Llorens, F.; Moreno, J.; Aso, E.; Ferrer, I. Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model. Neuroscience 2013, 248C, 369-382, 10.1016/j.neuroscience.2013.06.034
-
(2013)
Neuroscience
, vol.248 C
, pp. 369-382
-
-
Ansoleaga, B.1
Garcia-Esparcia, P.2
Llorens, F.3
Moreno, J.4
Aso, E.5
Ferrer, I.6
-
55
-
-
84865770759
-
Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem
-
Dehkordi, O.; Rose, J. E.; Fatemi, M.; Allard, J. S.; Balan, K. V.; Young, J. K.; Fatima, S.; Millis, R. M.; Jayam-Trouth, A. Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem. Brain Res. 2012, 1475, 1-10, 10.1016/j.brainres.2012.07.038
-
(2012)
Brain Res.
, vol.1475
, pp. 1-10
-
-
Dehkordi, O.1
Rose, J.E.2
Fatemi, M.3
Allard, J.S.4
Balan, K.V.5
Young, J.K.6
Fatima, S.7
Millis, R.M.8
Jayam-Trouth, A.9
-
56
-
-
84878653809
-
Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: Novel putative chemoreceptors in the human brain
-
Garcia-Esparcia, P.; Schluter, A.; Carmona, M.; Moreno, J.; Ansoleaga, B.; Torrejon-Escribano, B.; Gustincich, S.; Pujol, A.; Ferrer, I. Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain. J. Neuropathol. Exp. Neurol. 2013, 72, 524-539, 10.1097/NEN.0b013e318294fd76
-
(2013)
J. Neuropathol. Exp. Neurol.
, vol.72
, pp. 524-539
-
-
Garcia-Esparcia, P.1
Schluter, A.2
Carmona, M.3
Moreno, J.4
Ansoleaga, B.5
Torrejon-Escribano, B.6
Gustincich, S.7
Pujol, A.8
Ferrer, I.9
-
57
-
-
79952186028
-
Functional bitter taste receptors are expressed in brain cells
-
Singh, N.; Vrontakis, M.; Parkinson, F.; Chelikani, P. Functional bitter taste receptors are expressed in brain cells. Biochem. Biophys. Res. Commun. 2011, 406, 146-151, 10.1016/j.bbrc.2011.02.016
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.406
, pp. 146-151
-
-
Singh, N.1
Vrontakis, M.2
Parkinson, F.3
Chelikani, P.4
-
58
-
-
84905571552
-
Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation
-
Ekoff, M.; Choi, J. H.; James, A.; Dahlen, B.; Nilsson, G.; Dahlen, S. E. Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation. J. Allergy Clin. Immunol. 2014, 134, 475-478, 10.1016/j.jaci.2014.02.029
-
(2014)
J. Allergy Clin. Immunol.
, vol.134
, pp. 475-478
-
-
Ekoff, M.1
Choi, J.H.2
James, A.3
Dahlen, B.4
Nilsson, G.5
Dahlen, S.E.6
-
59
-
-
84928774470
-
Class i odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes
-
Malki, A.; Fiedler, J.; Fricke, K.; Ballweg, I.; Pfaffl, M. W.; Krautwurst, D. Class I odorant receptors, TAS1R and TAS2R taste receptors, are markers for subpopulations of circulating leukocytes. J. Leukocyte Biol. 2015, 97, 533-545, 10.1189/jlb.2A0714-331RR
-
(2015)
J. Leukocyte Biol.
, vol.97
, pp. 533-545
-
-
Malki, A.1
Fiedler, J.2
Fricke, K.3
Ballweg, I.4
Pfaffl, M.W.5
Krautwurst, D.6
-
60
-
-
85008422911
-
-
Springer: Berlin, Germanyp, 10.1007/7355-2016-101
-
Marcinek, P.; Geithe, C.; Krautwurst, D. Chemosensory G Protein-Coupled Receptors (GPCR) in Blood Leukocytes; Springer: Berlin, Germany, 2016; pp 1-23, DOI: 10.1007/7355-2016-101.
-
(2016)
Chemosensory G Protein-Coupled Receptors (GPCR) in Blood Leukocytes
, pp. 1-23
-
-
Marcinek, P.1
Geithe, C.2
Krautwurst, D.3
-
61
-
-
84938505828
-
Tasting Pseudomonas aeruginosa biofilms: Human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone
-
Maurer, S.; Wabnitz, G. H.; Kahle, N. A.; Stegmaier, S.; Prior, B.; Giese, T.; Gaida, M. M.; Samstag, Y.; Hansch, G. M. Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. Front. Immunol. 2015, 6, 369, 10.3389/fimmu.2015.00369
-
(2015)
Front. Immunol.
, vol.6
, pp. 369
-
-
Maurer, S.1
Wabnitz, G.H.2
Kahle, N.A.3
Stegmaier, S.4
Prior, B.5
Giese, T.6
Gaida, M.M.7
Samstag, Y.8
Hansch, G.M.9
-
62
-
-
84880170996
-
Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics
-
Orsmark-Pietras, C.; James, A.; Konradsen, J. R.; Nordlund, B.; Soderhall, C.; Pulkkinen, V.; Pedroletti, C.; Daham, K.; Kupczyk, M.; Dahlen, B.; Kere, J.; Dahlen, S. E.; Hedlin, G.; Melen, E. Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics. Eur. Respir. J. 2013, 42, 65-78, 10.1183/09031936.00077712
-
(2013)
Eur. Respir. J.
, vol.42
, pp. 65-78
-
-
Orsmark-Pietras, C.1
James, A.2
Konradsen, J.R.3
Nordlund, B.4
Soderhall, C.5
Pulkkinen, V.6
Pedroletti, C.7
Daham, K.8
Kupczyk, M.9
Dahlen, B.10
Kere, J.11
Dahlen, S.E.12
Hedlin, G.13
Melen, E.14
-
63
-
-
84880681249
-
Taste perception: From the tongue to the testis
-
Li, F. Taste perception: from the tongue to the testis. Mol. Hum. Reprod. 2013, 19, 349-360, 10.1093/molehr/gat009
-
(2013)
Mol. Hum. Reprod.
, vol.19
, pp. 349-360
-
-
Li, F.1
-
64
-
-
84907692946
-
Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart
-
Foster, S. R.; Blank, K.; See Hoe, L. E.; Behrens, M.; Meyerhof, W.; Peart, J. N.; Thomas, W. G. Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB J. 2014, 28, 4497-4508, 10.1096/fj.14-256305
-
(2014)
FASEB J.
, vol.28
, pp. 4497-4508
-
-
Foster, S.R.1
Blank, K.2
See Hoe, L.E.3
Behrens, M.4
Meyerhof, W.5
Peart, J.N.6
Thomas, W.G.7
-
65
-
-
84877790035
-
Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart
-
Foster, S. R.; Porrello, E. R.; Purdue, B.; Chan, H. W.; Voigt, A.; Frenzel, S.; Hannan, R. D.; Moritz, K. M.; Simmons, D. G.; Molenaar, P.; Roura, E.; Boehm, U.; Meyerhof, W.; Thomas, W. G. Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart. PLoS One 2013, 8, e64579, 10.1371/journal.pone.0064579
-
(2013)
PLoS One
, vol.8
, pp. e64579
-
-
Foster, S.R.1
Porrello, E.R.2
Purdue, B.3
Chan, H.W.4
Voigt, A.5
Frenzel, S.6
Hannan, R.D.7
Moritz, K.M.8
Simmons, D.G.9
Molenaar, P.10
Roura, E.11
Boehm, U.12
Meyerhof, W.13
Thomas, W.G.14
-
66
-
-
84920151364
-
Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes
-
Behrens, M.; Korsching, S. I.; Meyerhof, W. Tuning properties of avian and frog bitter taste receptors dynamically fit gene repertoire sizes. Mol. Biol. Evol. 2014, 31, 3216-3227, 10.1093/molbev/msu254
-
(2014)
Mol. Biol. Evol.
, vol.31
, pp. 3216-3227
-
-
Behrens, M.1
Korsching, S.I.2
Meyerhof, W.3
-
67
-
-
84949435886
-
Functional analyses of bitter taste receptors in domestic cats (Felis catus)
-
Lei, W.; Ravoninjohary, A.; Li, X.; Margolskee, R. F.; Reed, D. R.; Beauchamp, G. K.; Jiang, P. Functional analyses of bitter taste receptors in domestic cats (Felis catus). PLoS One 2015, 10, e0139670, 10.1371/journal.pone.0139670
-
(2015)
PLoS One
, vol.10
, pp. e0139670
-
-
Lei, W.1
Ravoninjohary, A.2
Li, X.3
Margolskee, R.F.4
Reed, D.R.5
Beauchamp, G.K.6
Jiang, P.7
-
68
-
-
84930649234
-
A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs
-
Sandau, M. M.; Goodman, J. R.; Thomas, A.; Rucker, J. B.; Rawson, N. E. A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs. BMC Neurosci. 2015, 16, 33, 10.1186/s12868-015-0170-6
-
(2015)
BMC Neurosci.
, vol.16
, pp. 33
-
-
Sandau, M.M.1
Goodman, J.R.2
Thomas, A.3
Rucker, J.B.4
Rawson, N.E.5
-
69
-
-
84978401133
-
Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans
-
Lossow, K.; Hubner, S.; Roudnitzky, N.; Slack, J. P.; Pollastro, F.; Behrens, M.; Meyerhof, W. Comprehensive analysis of mouse bitter taste receptors reveals different molecular receptive ranges for orthologous receptors in mice and humans. J. Biol. Chem. 2016, 291, 15358-15377, 10.1074/jbc.M116.718544
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 15358-15377
-
-
Lossow, K.1
Hubner, S.2
Roudnitzky, N.3
Slack, J.P.4
Pollastro, F.5
Behrens, M.6
Meyerhof, W.7
-
70
-
-
33751084573
-
The receptors and cells for mammalian taste
-
Chandrashekar, J.; Hoon, M. A.; Ryba, N. J.; Zuker, C. S. The receptors and cells for mammalian taste. Nature 2006, 444, 288-294, 10.1038/nature05401
-
(2006)
Nature
, vol.444
, pp. 288-294
-
-
Chandrashekar, J.1
Hoon, M.A.2
Ryba, N.J.3
Zuker, C.S.4
-
71
-
-
15044353688
-
The receptors and coding logic for bitter taste
-
Mueller, K. L.; Hoon, M. A.; Erlenbach, I.; Chandrashekar, J.; Zuker, C. S.; Ryba, N. J. The receptors and coding logic for bitter taste. Nature 2005, 434, 225-229, 10.1038/nature03352
-
(2005)
Nature
, vol.434
, pp. 225-229
-
-
Mueller, K.L.1
Hoon, M.A.2
Erlenbach, I.3
Chandrashekar, J.4
Zuker, C.S.5
Ryba, N.J.6
-
72
-
-
0035936911
-
Taste receptor cells that discriminate between bitter stimuli
-
Caicedo, A.; Roper, S. D. Taste receptor cells that discriminate between bitter stimuli. Science 2001, 291, 1557-1560, 10.1126/science.1056670
-
(2001)
Science
, vol.291
, pp. 1557-1560
-
-
Caicedo, A.1
Roper, S.D.2
-
73
-
-
79952138344
-
Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
-
Janssen, S.; Laermans, J.; Verhulst, P. J.; Thijs, T.; Tack, J.; Depoortere, I. Bitter taste receptors and alpha-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 2094-2099, 10.1073/pnas.1011508108
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 2094-2099
-
-
Janssen, S.1
Laermans, J.2
Verhulst, P.J.3
Thijs, T.4
Tack, J.5
Depoortere, I.6
-
74
-
-
55849136194
-
SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
-
Jeon, T. I.; Zhu, B.; Larson, J. L.; Osborne, T. F. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J. Clin. Invest. 2008, 118, 3693-3700, 10.1172/JCI36461
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3693-3700
-
-
Jeon, T.I.1
Zhu, B.2
Larson, J.L.3
Osborne, T.F.4
-
75
-
-
84907197891
-
Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract
-
Vegezzi, G.; Anselmi, L.; Huynh, J.; Barocelli, E.; Rozengurt, E.; Raybould, H.; Sternini, C. Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. PLoS One 2014, 9, e107732, 10.1371/journal.pone.0107732
-
(2014)
PLoS One
, vol.9
, pp. e107732
-
-
Vegezzi, G.1
Anselmi, L.2
Huynh, J.3
Barocelli, E.4
Rozengurt, E.5
Raybould, H.6
Sternini, C.7
-
76
-
-
84893347143
-
A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131
-
Prandi, S.; Bromke, M.; Hubner, S.; Voigt, A.; Boehm, U.; Meyerhof, W.; Behrens, M. A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One 2013, 8, e82820, 10.1371/journal.pone.0082820
-
(2013)
PLoS One
, vol.8
, pp. e82820
-
-
Prandi, S.1
Bromke, M.2
Hubner, S.3
Voigt, A.4
Boehm, U.5
Meyerhof, W.6
Behrens, M.7
-
77
-
-
80053906739
-
Structural basis of activation of bitter taste receptor T2R1 and comparison with class A GPCRs
-
Singh, N.; Pydi, P.; Upadhyaya, J.; Chelikani, P. Structural basis of activation of bitter taste receptor T2R1 and comparison with class A GPCRs. J. Biol. Chem. 2011, 286, 36032-36041, 10.1074/jbc.M111.246983
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 36032-36041
-
-
Singh, N.1
Pydi, P.2
Upadhyaya, J.3
Chelikani, P.4
-
78
-
-
84884872511
-
Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells
-
Lipchock, S. V.; Mennella, J. A.; Spielman, A. I.; Reed, D. R. Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. Am. J. Clin. Nutr. 2013, 98, 1136-1143, 10.3945/ajcn.113.066688
-
(2013)
Am. J. Clin. Nutr.
, vol.98
, pp. 1136-1143
-
-
Lipchock, S.V.1
Mennella, J.A.2
Spielman, A.I.3
Reed, D.R.4
-
79
-
-
84942807956
-
Genetic and metabolic determinants of human epigenetic variation
-
Haggarty, P. Genetic and metabolic determinants of human epigenetic variation. Curr. Opin. Clin. Nutr. Metab. Care 2015, 18, 334-338, 10.1097/MCO.0000000000000194
-
(2015)
Curr. Opin. Clin. Nutr. Metab. Care
, vol.18
, pp. 334-338
-
-
Haggarty, P.1
-
80
-
-
0024520027
-
Enzyme/crystallins: Gene sharing as an evolutionary strategy
-
Piatigorsky, J.; Wistow, G. J. Enzyme/crystallins: gene sharing as an evolutionary strategy. Cell 1989, 57, 197-199, 10.1016/0092-8674(89)90956-2
-
(1989)
Cell
, vol.57
, pp. 197-199
-
-
Piatigorsky, J.1
Wistow, G.J.2
-
81
-
-
27944434112
-
Elucidation of mammalian bitter taste
-
Meyerhof, W. Elucidation of mammalian bitter taste. Rev. Physiol. Biochem. Pharmacol. 2005, 154, 37-72, 10.1007/s10254-005-0041-0
-
(2005)
Rev. Physiol. Biochem. Pharmacol.
, vol.154
, pp. 37-72
-
-
Meyerhof, W.1
-
82
-
-
84856499826
-
BitterDB: A database of bitter compounds
-
Wiener, A.; Shudler, M.; Levit, A.; Niv, M. Y. BitterDB: a database of bitter compounds. Nucleic Acids Res. 2012, 40, D413-419, 10.1093/nar/gkr755
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D413-D419
-
-
Wiener, A.1
Shudler, M.2
Levit, A.3
Niv, M.Y.4
-
83
-
-
84947601097
-
Phytochemicals from Ruta graveolens activate TAS2R bitter taste receptors and TRP channels involved in gustation and nociception
-
Mancuso, G.; Borgonovo, G.; Scaglioni, L.; Bassoli, A. Phytochemicals from Ruta graveolens activate TAS2R bitter taste receptors and TRP channels involved in gustation and nociception. Molecules 2015, 20, 18907-18922, 10.3390/molecules201018907
-
(2015)
Molecules
, vol.20
, pp. 18907-18922
-
-
Mancuso, G.1
Borgonovo, G.2
Scaglioni, L.3
Bassoli, A.4
-
84
-
-
84958550454
-
TRPs in taste and chemesthesis
-
Roper, S. D. TRPs in taste and chemesthesis. Handb. Exp. Pharmacol. 2014, 223, 827-871, 10.1007/978-3-319-05161-1-5
-
(2014)
Handb. Exp. Pharmacol.
, vol.223
, pp. 827-871
-
-
Roper, S.D.1
-
85
-
-
84965132599
-
Salivary protein levels as a predictor of perceived astringency in model systems and solid foods
-
Fleming, E. E.; Ziegler, G. R.; Hayes, J. E. Salivary protein levels as a predictor of perceived astringency in model systems and solid foods. Physiol. Behav. 2016, 163, 56-63, 10.1016/j.physbeh.2016.04.043
-
(2016)
Physiol. Behav.
, vol.163
, pp. 56-63
-
-
Fleming, E.E.1
Ziegler, G.R.2
Hayes, J.E.3
-
86
-
-
84902985704
-
Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds
-
Schobel, N.; Radtke, D.; Kyereme, J.; Wollmann, N.; Cichy, A.; Obst, K.; Kallweit, K.; Kletke, O.; Minovi, A.; Dazert, S.; Wetzel, C. H.; Vogt-Eisele, A.; Gisselmann, G.; Ley, J. P.; Bartoshuk, L. M.; Spehr, J.; Hofmann, T.; Hatt, H. Astringency is a trigeminal sensation that involves the activation of G protein-coupled signaling by phenolic compounds. Chem. Senses 2014, 39, 471-487, 10.1093/chemse/bju014
-
(2014)
Chem. Senses
, vol.39
, pp. 471-487
-
-
Schobel, N.1
Radtke, D.2
Kyereme, J.3
Wollmann, N.4
Cichy, A.5
Obst, K.6
Kallweit, K.7
Kletke, O.8
Minovi, A.9
Dazert, S.10
Wetzel, C.H.11
Vogt-Eisele, A.12
Gisselmann, G.13
Ley, J.P.14
Bartoshuk, L.M.15
Spehr, J.16
Hofmann, T.17
Hatt, H.18
-
87
-
-
84898420357
-
Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3
-
Gees, M.; Alpizar, Y. A.; Luyten, T.; Parys, J. B.; Nilius, B.; Bultynck, G.; Voets, T.; Talavera, K. Differential effects of bitter compounds on the taste transduction channels TRPM5 and IP3 receptor type 3. Chem. Senses 2014, 39, 295-311, 10.1093/chemse/bjt115
-
(2014)
Chem. Senses
, vol.39
, pp. 295-311
-
-
Gees, M.1
Alpizar, Y.A.2
Luyten, T.3
Parys, J.B.4
Nilius, B.5
Bultynck, G.6
Voets, T.7
Talavera, K.8
-
88
-
-
0033982652
-
Rapid entry of bitter and sweet tastants into liposomes and taste cells: Implications for signal transduction
-
Peri, I.; Mamrud-Brains, H.; Rodin, S.; Krizhanovsky, V.; Shai, Y.; Nir, S.; Naim, M. Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction. Am. J. Physiol. Cell Physiol. 2000, 278, C17-C25
-
(2000)
Am. J. Physiol. Cell Physiol.
, vol.278
, pp. C17-C25
-
-
Peri, I.1
Mamrud-Brains, H.2
Rodin, S.3
Krizhanovsky, V.4
Shai, Y.5
Nir, S.6
Naim, M.7
-
89
-
-
84932649897
-
Nicotinic acetylcholine receptor (nAChR) dependent chorda tympani taste nerve responses to nicotine, ethanol and acetylcholine
-
Ren, Z. J.; Mummalaneni, S.; Qian, J.; Baumgarten, C. M.; DeSimone, J. A.; Lyall, V. Nicotinic acetylcholine receptor (nAChR) dependent chorda tympani taste nerve responses to nicotine, ethanol and acetylcholine. PLoS One 2015, 10, e0127936, 10.1371/journal.pone.0127936
-
(2015)
PLoS One
, vol.10
, pp. e0127936
-
-
Ren, Z.J.1
Mummalaneni, S.2
Qian, J.3
Baumgarten, C.M.4
DeSimone, J.A.5
Lyall, V.6
-
90
-
-
84978420035
-
The taste of health: Nature's bitter gifts
-
Barratt-Fornell, A.; Drewnowski, A. The taste of health: nature's bitter gifts. Nutr. Today 2002, 37, 144-150, 10.1097/00017285-200207000-00003
-
(2002)
Nutr. Today
, vol.37
, pp. 144-150
-
-
Barratt-Fornell, A.1
Drewnowski, A.2
-
91
-
-
0040209829
-
Strychnine binding associated with glycine receptors of the central nervous system
-
Young, A. B.; Snyder, S. H. Strychnine binding associated with glycine receptors of the central nervous system. Proc. Natl. Acad. Sci. U. S. A. 1973, 70, 2832-2836, 10.1073/pnas.70.10.2832
-
(1973)
Proc. Natl. Acad. Sci. U. S. A.
, vol.70
, pp. 2832-2836
-
-
Young, A.B.1
Snyder, S.H.2
-
92
-
-
0033520430
-
Interaction of non-competitive blockers within the gamma-aminobutyric acid type A chloride channel using chemically reactive probes as chemical sensors for cysteine mutants
-
Perret, P.; Sarda, X.; Wolff, M.; Wu, T. T.; Bushey, D.; Goeldner, M. Interaction of non-competitive blockers within the gamma-aminobutyric acid type A chloride channel using chemically reactive probes as chemical sensors for cysteine mutants. J. Biol. Chem. 1999, 274, 25350-25354, 10.1074/jbc.274.36.25350
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25350-25354
-
-
Perret, P.1
Sarda, X.2
Wolff, M.3
Wu, T.T.4
Bushey, D.5
Goeldner, M.6
-
93
-
-
34547802810
-
Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
-
Brockhoff, A.; Behrens, M.; Massarotti, A.; Appendino, G.; Meyerhof, W. Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J. Agric. Food Chem. 2007, 55, 6236-6243, 10.1021/jf070503p
-
(2007)
J. Agric. Food Chem.
, vol.55
, pp. 6236-6243
-
-
Brockhoff, A.1
Behrens, M.2
Massarotti, A.3
Appendino, G.4
Meyerhof, W.5
-
94
-
-
0346219334
-
Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization
-
Deiml, T.; Haseneder, R.; Zieglgansberger, W.; Rammes, G.; Eisensamer, B.; Rupprecht, R.; Hapfelmeier, G. Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization. Neuropharmacology 2004, 46, 192-201, 10.1016/j.neuropharm.2003.09.022
-
(2004)
Neuropharmacology
, vol.46
, pp. 192-201
-
-
Deiml, T.1
Haseneder, R.2
Zieglgansberger, W.3
Rammes, G.4
Eisensamer, B.5
Rupprecht, R.6
Hapfelmeier, G.7
-
95
-
-
77950494200
-
Binding, activation and modulation of Cys-loop receptors
-
Miller, P. S.; Smart, T. G. Binding, activation and modulation of Cys-loop receptors. Trends Pharmacol. Sci. 2010, 31, 161-174, 10.1016/j.tips.2009.12.005
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 161-174
-
-
Miller, P.S.1
Smart, T.G.2
-
96
-
-
0027509620
-
Qinghaosu
-
Hien, T. T.; White, N. J. Qinghaosu. Lancet 1993, 341, 603-608, 10.1016/0140-6736(93)90362-K
-
(1993)
Lancet
, vol.341
, pp. 603-608
-
-
Hien, T.T.1
White, N.J.2
-
97
-
-
0034527045
-
The fight against rheumatism: From willow bark to COX-1 sparing drugs
-
Vane, J. R. The fight against rheumatism: from willow bark to COX-1 sparing drugs. J. Physiol. Pharmacol. 2000, 51, 573-586
-
(2000)
J. Physiol. Pharmacol.
, vol.51
, pp. 573-586
-
-
Vane, J.R.1
-
98
-
-
84930870868
-
Promiscuity and selectivity of bitter molecules and their receptors
-
Di Pizio, A.; Niv, M. Y. Promiscuity and selectivity of bitter molecules and their receptors. Bioorg. Med. Chem. 2015, 23, 4082-4091, 10.1016/j.bmc.2015.04.025
-
(2015)
Bioorg. Med. Chem.
, vol.23
, pp. 4082-4091
-
-
Di Pizio, A.1
Niv, M.Y.2
-
99
-
-
77955710004
-
Modulation of bitter taste perception by a small molecule hTAS2R antagonist
-
Slack, J. P.; Brockhoff, A.; Batram, C.; Menzel, S.; Sonnabend, C.; Born, S.; Galindo, M. M.; Kohl, S.; Thalmann, S.; Ostopovici-Halip, L.; Simons, C. T.; Ungureanu, I.; Duineveld, K.; Bologa, C. G.; Behrens, M.; Furrer, S.; Oprea, T. I.; Meyerhof, W. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr. Biol. 2010, 20, 1104-1109, 10.1016/j.cub.2010.04.043
-
(2010)
Curr. Biol.
, vol.20
, pp. 1104-1109
-
-
Slack, J.P.1
Brockhoff, A.2
Batram, C.3
Menzel, S.4
Sonnabend, C.5
Born, S.6
Galindo, M.M.7
Kohl, S.8
Thalmann, S.9
Ostopovici-Halip, L.10
Simons, C.T.11
Ungureanu, I.12
Duineveld, K.13
Bologa, C.G.14
Behrens, M.15
Furrer, S.16
Oprea, T.I.17
Meyerhof, W.18
-
100
-
-
80054012779
-
Receptor agonism and antagonism of dietary bitter compounds
-
Brockhoff, A.; Behrens, M.; Roudnitzky, N.; Appendino, G.; Avonto, C.; Meyerhof, W. Receptor agonism and antagonism of dietary bitter compounds. J. Neurosci. 2011, 31, 14775-14782, 10.1523/JNEUROSCI.2923-11.2011
-
(2011)
J. Neurosci.
, vol.31
, pp. 14775-14782
-
-
Brockhoff, A.1
Behrens, M.2
Roudnitzky, N.3
Appendino, G.4
Avonto, C.5
Meyerhof, W.6
-
101
-
-
79956347958
-
Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin
-
Greene, T. A.; Alarcon, S.; Thomas, A.; Berdougo, E.; Doranz, B. J.; Breslin, P. A.; Rucker, J. B. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One 2011, 6, e20123, 10.1371/journal.pone.0020123
-
(2011)
PLoS One
, vol.6
, pp. e20123
-
-
Greene, T.A.1
Alarcon, S.2
Thomas, A.3
Berdougo, E.4
Doranz, B.J.5
Breslin, P.A.6
Rucker, J.B.7
-
102
-
-
84899537099
-
6-Methoxyflavanones as bitter taste receptor blockers for hTAS2R39
-
Roland, W. S.; Gouka, R. J.; Gruppen, H.; Driesse, M.; van Buren, L.; Smit, G.; Vincken, J. P. 6-Methoxyflavanones as bitter taste receptor blockers for hTAS2R39. PLoS One 2014, 9, e94451, 10.1371/journal.pone.0094451
-
(2014)
PLoS One
, vol.9
, pp. e94451
-
-
Roland, W.S.1
Gouka, R.J.2
Gruppen, H.3
Driesse, M.4
Van Buren, L.5
Smit, G.6
Vincken, J.P.7
-
103
-
-
0018583620
-
Three-dimensional mapping of the bitter taste receptor site
-
Tancredi, T.; Lelj, F.; Temussi, P. A. Three-dimensional mapping of the bitter taste receptor site. Chem. Senses 1979, 4, 259-265, 10.1093/chemse/4.4.259
-
(1979)
Chem. Senses
, vol.4
, pp. 259-265
-
-
Tancredi, T.1
Lelj, F.2
Temussi, P.A.3
-
104
-
-
0014192965
-
Molecular theory of sweet taste
-
Shallenberger, R. S.; Acree, T. E. Molecular theory of sweet taste. Nature 1967, 216, 480-482, 10.1038/216480a0
-
(1967)
Nature
, vol.216
, pp. 480-482
-
-
Shallenberger, R.S.1
Acree, T.E.2
-
105
-
-
0014667672
-
Sweet taste of d - And l -sugars and amino-acids and the steric nature of their chemo-receptor site
-
Shallenberger, R. S.; Acree, T. E.; Lee, C. Y. Sweet taste of d-and l -sugars and amino-acids and the steric nature of their chemo-receptor site. Nature 1969, 221, 555-556, 10.1038/221555a0
-
(1969)
Nature
, vol.221
, pp. 555-556
-
-
Shallenberger, R.S.1
Acree, T.E.2
Lee, C.Y.3
-
106
-
-
84973879531
-
Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists
-
Karaman, R.; Nowak, S.; Di Pizio, A.; Kitaneh, H.; Abu-Jaish, A.; Meyerhof, W.; Niv, M. Y.; Behrens, M. Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists. Chem. Biol. Drug Des. 2016, 88, 66-75, 10.1111/cbdd.12734
-
(2016)
Chem. Biol. Drug Des.
, vol.88
, pp. 66-75
-
-
Karaman, R.1
Nowak, S.2
Di Pizio, A.3
Kitaneh, H.4
Abu-Jaish, A.5
Meyerhof, W.6
Niv, M.Y.7
Behrens, M.8
-
107
-
-
84899503308
-
The bitter pill: Clinical drugs that activate the human bitter taste receptor TAS2R14
-
Levit, A.; Nowak, S.; Peters, M.; Wiener, A.; Meyerhof, W.; Behrens, M.; Niv, M. Y. The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J. 2014, 28, 1181-1197, 10.1096/fj.13-242594
-
(2014)
FASEB J.
, vol.28
, pp. 1181-1197
-
-
Levit, A.1
Nowak, S.2
Peters, M.3
Wiener, A.4
Meyerhof, W.5
Behrens, M.6
Niv, M.Y.7
-
108
-
-
0028565353
-
Chemical mimicry and camouflage
-
Dettner, K.; Liepert, C. Chemical mimicry and camouflage. Annu. Rev. Entomol. 1994, 39, 129-154, 10.1146/annurev.en.39.010194.001021
-
(1994)
Annu. Rev. Entomol.
, vol.39
, pp. 129-154
-
-
Dettner, K.1
Liepert, C.2
|