The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands

Journal of Neuroscience

Volumn 33, Issue 1, 2013, Pages 201-213

  Born, Stephan ^a   Levit, Anat ^b   Niv, Masha Y ^b   Meyerhof, Wolfgang ^a   Behrens, Maik ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CUCURBITACIN; DENATONIUM BENZOATE; G PROTEIN COUPLED BITTER TASTE RECEPTOR; G PROTEIN COUPLED RECEPTOR; PAPAVERINE; SANTONIN; STRYCHNINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BITTER TASTE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOLECULAR DOCKING; POINT MUTATION; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; TASTE BUD;

BIOLOGICAL EVOLUTION; CHLORAMPHENICOL; HUMANS; LIGANDS; MUTATION; PAPAVERINE; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, G-PROTEIN-COUPLED; SANTONIN; STRYCHNINE; TASTE; TASTE BUDS;

EID: 84871753673     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3248-12.2013     Document Type: Article

References (36)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000) A novel family of mammalian taste receptors. Cell 100:693-702. CrossRef Medline
2. Armougom F, Moretti S, Poirot O, Audic S, Dumas P, Schaeli B, Keduas V, Notredame C (2006) Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-Coffee. Nucleic Acids Res 34:W604-W608. CrossRef Medline
3. Ballesteros J, Weinstein H (1995) Integrated methods for the construction of three-dimensional models of structure-function relations in G-protein-coupled receptors. Methods Neurosci 25:366-428. CrossRef
4. Behrens M, Brockhoff A, Kuhn C, Bufe B, Winnig M, Meyerhof W (2004) The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem Biophys Res Commun 319:479-485. CrossRef Medline
5. Behrens M, Bartelt J, Reichling C, Winnig M, Kuhn C, Meyerhof W (2006) Members of RTP and REEP gene families influence functional bitter taste receptor expression. J Biol Chem 281:20650-20659. CrossRef Medline
6. Behrens M, Brockhoff A, Batram C, Kuhn C, Appendino G, Meyerhof W (2009) The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin. J Agric Food Chem 57:9860-9866. CrossRef Medline
7. Biarnes X, Marchiori A, Giorgetti A, Lanzara C, Gasparini P, Carloni P, Born S, Brockhoff A, Behrens M, Meyerhof W (2010) Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. PLoS One 5:12394. CrossRef Medline
8. Brockhoff A, Behrens M, Massarotti A, Appendino G, Meyerhof W (2007) Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. J Agric Food Chem 55:6236-6243. CrossRef Medline
9. Brockhoff A, Behrens M, Niv MY, Meyerhof W (2010) Structural requirements of bitter taste receptor activation. Proc Natl Acad Sci U S A 107: 11110-11115. CrossRef Medline
10. Brockhoff A, Behrens M, Roudnitzky N, Appendino G, Avonto C, Meyerhof W (2011) Receptor agonism and antagonism of dietary bitter compounds. J Neurosci 31:14775-14782. CrossRef Medline
11. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002) The human TAS2R16 receptor mediates bitter taste in response to betaglucopyranosides. Nat Genet 32:397-401. CrossRef Medline
12. Crooks GE, Hon G, Chandonia JM, Brenner SE (2004) WebLogo: a sequence logo generator. Genome Res 14:1188-1190. CrossRef Medline
13. Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, Han GW, Kuhn P, Rosen H, Stevens RC (2012) Crystal structure of a lipid G proteincoupled receptor. Science 335:851-855. CrossRef Medline
14. Katritch V, Cherezov V, Stevens RC (2012) Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci 33:17-27. CrossRef Medline
15. Krivov GG, Shapovalov MV, Dunbrack RL Jr (2009) Improved prediction of protein side-chain conformations with SCWRL4. Proteins 77:778-795. CrossRef Medline
16. Laurie AT, Jackson RM (2005) Q-SiteFinder: an energy-based method for the prediction of protein-ligand binding sites. Bioinformatics 21:1908-1916. CrossRef Medline
17. Matsunami H, Montmayeur JP, Buck LB (2000) A family of candidate taste receptors in human and mouse. Nature 404:601-604. CrossRef Medline
18. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35:157-170. CrossRef Medline
19. Notredame C, Higgins DG, Heringa J (2000) T-Coffee: a novel method for fast and accurate multiple sequence alignment. J Mol Biol 302:205-217. CrossRef Medline
20. Olias G, Viollet C, Kusserow H, Epelbaum J, Meyerhof W (2004) Regulation and function of somatostatin receptors. J Neurochem 89:1057-1091. CrossRef Medline
21. Pronin AN, Tang H, Connor J, Keung W (2004) Identification of ligands for two human bitter T2R receptors. Chem Senses 29:583-593. CrossRef Medline
22. Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK (2011) Crystal structure of the beta(2) adrenergic receptor- Gs-protein complex. Nature 477:549-555. CrossRef Medline
23. Sakurai T, Misaka T, Ueno Y, Ishiguro M, Matsuo S, Ishimaru Y, Asakura T, Abe K (2010a) The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides. Biochem Biophys Res Commun 402:595-601. CrossRef Medline
24. Sakurai T, Misaka T, Ishiguro M, Masuda K, Sugawara T, Ito K, Kobayashi T, Matsuo S, Ishimaru Y, Asakura T, Abe K (2010b) Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16. J Biol Chem 285:28373-28378. CrossRef Medline
25. Shi P, Zhang J (2006) Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol 23:292-300. CrossRef Medline
26. Shi P, Zhang J, Yang H, Zhang YP (2003) Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol 20:805-814. CrossRef Medline
27. Shimamura T, Shiroishi M, Weyand S, Tsujimoto H, Winter G, Katritch V, Abagyan R, Cherezov V, Liu W, Han GW, Kobayashi T, Stevens RC, Iwata S (2011) Structure of the human histamine H1 receptor complex with doxepin. Nature 475:65-70. CrossRef Medline
28. Singh N, Pydi SP, Upadhyaya J, Chelikani P (2011) Structural basis of activation of bitter taste receptor T2R1 and comparison with class A GPCRs. J Biol Chem 286:36032-36041. CrossRef Medline
29. Slack JP, Brockhoff A, Batram C, Menzel S, Sonnabend C, Born S, Galindo MM, Kohl S, Thalmann S, Ostopovici-Halip L, Simons CT, Ungureanu I, Duineveld K, Bologa CG, Behrens M, Furrer S, Oprea TI, Meyerhof W (2010) Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol 20:1104-1109. CrossRef Medline
30. Soranzo N, Bufe B, Sabeti PC, Wilson JF, Weale ME, Marguerie R, Meyerhof W, Goldstein DB (2005) Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr Biol 15:1257-1265. CrossRef Medline
31. Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S (2003) Functional interaction between T2R taste receptors and G-protein alpha subunits expressed in taste receptor cells. J Neurosci 23:7376-7380. Medline
32. Upadhyaya J, Pydi SP, Singh N, Aluko RE, Chelikani P (2010) Bitter taste receptor T2R1 is activated by dipeptides and tripeptides. Biochem Biophys Res Commun 398:331-335. CrossRef Medline
33. Valdar WS (2002) Scoring residue conservation. Proteins 48:227-241. CrossRef Medline
34. Wiener A, Shudler M, Levit A, Niv MY (2012) BitterDB: a database of bitter compounds. Nucleic Acids Res 40:D413-D419. CrossRef Medline
35. Yarmolinsky DA, Zuker CS, Ryba NJ (2009) Common sense about taste: from mammals to insects. Cell 139:234-244. CrossRef Medline
36. Yarnitzky T, Levit A, Niv MY (2010) Homology modeling of G-proteincoupled receptors with X-ray structures on the rise. Curr Opin Drug Discov Devel 13:317-325. Medline