A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs

BMC Neuroscience

Volumn 16, Issue 1, 2015, Pages

  Sandau, Michelle M ^a   Goodman, Jason R ^b   Thomas, Anu ^b   Rucker, Joseph B ^b   Rawson, Nancy E ^a  

^a AFB International   (United States)

^b Integral Molecular Inc   (United States)

Author keywords

Bitter; domestic cat; feline; flavor; Tas2r38; Tas2r43; taste

Indexed keywords

AMINO ACID; LIGAND; PHENYLTHIOUREA; PROBENECID; PROPYLTHIOURACIL; SACCHARIN; AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; CALCIUM; G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BITTER TASTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOMESTIC CAT; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; HUMAN; NONHUMAN; ORTHOLOGY; PHENOTYPE; SENSITIVITY ANALYSIS; TAS2R38 GENE; TAS2R43 GENE; TASTE ACUITY; TASTE BUD; ANIMAL; ANTAGONISTS AND INHIBITORS; CAT; CELL LINE; CELL MEMBRANE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSFECTION; GENETICS; METABOLISM; SPECIES DIFFERENCE;

ANIMALS; CALCIUM; CATS; CELL LINE; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; PROBENECID; RECEPTORS, G-PROTEIN-COUPLED; SENSORY SYSTEM AGENTS; SPECIES SPECIFICITY; TRANSFECTION;

EID: 84930649234     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-015-0170-6     Document Type: Article

References (62)

1. Breslin PA. An evolutionary perspective on food and human taste. Curr Biol. 2013;23:R409-18.
2. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS. A novel family of mammalian taste receptors. Cell. 2000;100:693-702.
3. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, et al. T2Rs function as bitter taste receptors. Cell. 2000;100:703-11.
4. Matsunami H, Montmayeur JP, Buck LB. A family of candidate taste receptors in human and mouse. Nature. 2000;404:601-4.
5. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 2010;35:157-70.
6. Wiener A, Shudler M, Levit A, Niv MY. BitterDB: a database of bitter compounds. Nucleic Acids Res. 2012;40:D413-9.
7. Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet Genome Res. 2002;98:45-53.
8. Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 2005;26:199-204.
9. Drewnowski A, Gomez-Carneros C. Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr. 2000;72:1424-35.
10. Hofmann T. Taste-active maillard reaction products: the "tasty" world of nonvolatile maillard reaction products. Ann N Y Acad Sci. 2005;1043:20-9.
11. Maehashi K, Matano M, Wang H, Vo LA, Yamamoto Y, Huang L. Bitter peptides activate hTAS2Rs, the human bitter receptors. Biochem Biophys Res Commun. 2008;365:851-5.
12. Greene TA, Alarcon S, Thomas A, Berdougo E, Doranz BJ, Breslin PA, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One. 2011;6, e20123.
13. Brockhoff A, Behrens M, Roudnitzky N, Appendino G, Avonto C, Meyerhof W. Receptor agonism and antagonism of dietary bitter compounds. J Neurosci. 2011;31:14775-82.
14. Slack JP, Brockhoff A, Batram C, Menzel S, Sonnabend C, Born S, et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol. 2010;20:1104-9.
15. Kinnamon SC, Margolskee RF. Mechanisms of taste transduction. Curr Opin Neurobiol. 1996;6:506-13.
16. Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction. J Biol Chem. 2002;277:1-4.
17. Brockhoff A, Behrens M, Niv MY, Meyerhof W. Structural requirements of bitter taste receptor activation. Proc Natl Acad Sci U S A. 2010;107:11110-5.
18. Born S, Levit A, Niv MY, Meyerhof W, Behrens M. The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands. J Neurosci. 2013;33:201-13.
19. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 2005;15:322-7.
20. Pronin AN, Xu H, Tang H, Zhang L, Li Q, Li X. Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Curr Biol. 2007;17:1403-8.
21. Li D, Zhang J. Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol Biol Evol. 2014;31:303-9.
22. Bachmanov AA, Beauchamp GK. Taste receptor genes. Annu Rev Nutr. 2007;27:389-414.
23. Boughter JD, Jr., Bachmanov AA: Behavioral genetics and taste. BMC Neurosci 2007, 8 Suppl 3:S3.
24. Li X, Li W, Wang H, Cao J, Maehashi K, Huang L, et al. Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet. 2005;1:27-35.
25. Jiang P, Josue J, Li X, Glaser D, Li W, Brand JG, et al. Major taste loss in carnivorous mammals. Proc Natl Acad Sci U S A. 2012;109:4956-61.
26. Boudreau JC, Bradley BE, Bierer PR, Kruger S, Tsuchitani C. Single unit recordings from the geniculate ganglion of the facial nerve of the cat. Experimental brain research Experimentelle Hirnforschung Experimentation cerebrale. 1971;13:461-88.
27. Boudreau JCaW, T.D. Flavor Chemistry of Carnivore Taste Systems. In: ACS Symposium Series. Flavor Chemistry of Carnivore Taste Systems. 1978. p. 102-28.
28. Carpenter JA. Species differences in taste preferences. J Comp Physiol Psychol. 1956;49:139-44.
29. Mojet J, Christ-Hazelhof E, Heidema J. Taste perception with age: generic or specific losses in threshold sensitivity to the five basic tastes? Chem Senses. 2001;26:845-60.
30. McMahon DB, Shikata H, Breslin PA. Are human taste thresholds similar on the right and left sides of the tongue? Chem Senses. 2001;26:875-83.
31. Rofe PC, Anderson RS. Food preference in domestic pets. Proc Nutr Soc. 1970;29:330-5.
32. Biró Z, Lanszki J, Szemethy L, Heltai M, Randi E. Feeding habits of feral domestic cats (Felis catus), wild cats (Felis silvestris) and their hybrids: trophic niche overlap among cat groups in Hungary. J Zool. 2005;266:187-96.
33. Plantinga EA, Bosch G, Hendriks WH. Estimation of the dietary nutrient profile of free-roaming feral cats: possible implications for nutrition of domestic cats. Br J Nutr. 2011;106 Suppl 1:S35-48.
34. Lee RJ, Cohen NA. Bitter and sweet taste receptors in the respiratory epithelium in health and disease. J Mol Med (Berl). 2014;92:1235-44.
35. Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, Jiang P, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest. 2012;122:4145-59.
36. Tizzano M, Gulbransen BD, Vandenbeuch A, Clapp TR, Herman JP, Sibhatu HM, et al. Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals. Proc Natl Acad Sci U S A. 2010;107:3210-5.
37. Oike H, Nagai T, Furuyama A, Okada S, Aihara Y, Ishimaru Y, et al. Characterization of ligands for fish taste receptors. J Neurosci. 2007;27:5584-92.
38. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002;32:397-401.
39. Wooding S, Bufe B, Grassi C, Howard MT, Stone AC, Vazquez M, et al. Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature. 2006;440:930-4.
40. Imai H, Suzuki N, Ishimaru Y, Sakurai T, Yin L, Pan W, Abe K, Misaka T, Hirai H: Functional diversity of bitter taste receptor TAS2R16 in primates. Biol Lett 2012.
41. Pronin AN, Tang H, Connor J, Keung W. Identification of ligands for two human bitter T2R receptors. Chem Senses. 2004;29:583-93.
42. Behrens M, Korsching SI, Meyerhof W: Tuning Properties of Avian and Frog Bitter Taste Receptors Dynamically Fit Gene Repertoire sizes. Mol Biol Evol 2014.
43. Sainz E, Cavenagh MM, Gutierrez J, Battey JF, Northup JK, Sullivan SL. Functional characterization of human bitter taste receptors. Biochem J. 2007;403:537-43.
44. Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, et al. Bitter taste receptors for saccharin and acesulfame K. J Neurosci. 2004;24:10260-5.
45. Soranzo N, Bufe B, Sabeti PC, Wilson JF, Weale ME, Marguerie R, et al. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr Biol. 2005;15:1257-65.
46. Mullikin JC, Hansen NF, Shen L, Ebling H, Donahue WF, Tao W, et al. Light whole genome sequence for SNP discovery across domestic cat breeds. BMC Genomics. 2010;11:406.
47. Pontius JU, Mullikin JC, Smith DR, Lindblad-Toh K, Gnerre S, Clamp M, et al. Initial sequence and comparative analysis of the cat genome. Genome Res. 2007;17:1675-89.
48. Hu LL, Shi P. Smallest bitter taste receptor (T2Rs) gene repertoire in carnivores. Dongwuxue Yanjiu. 2013;34:E75-81.
49. Zhou Y, Dong D, Zhang S, Zhao H. Positive selection drives the evolution of bat bitter taste receptor genes. Biochem Genet. 2009;47:207-15.
50. Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Genetics. 2005;170:313-26.
51. Dong D, Jones G, Zhang S. Dynamic evolution of bitter taste receptor genes in vertebrates. BMC Evol Biol. 2009;9:12.
52. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science. 2003;299:1221-5.
53. Shi P, Zhang J, Yang H, Zhang YP. Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol. 2003;20:805-14.
54. Roudnitzky N, Bufe B, Thalmann S, Kuhn C, Gunn HC, Xing C, et al. Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners. Hum Mol Genet. 2011;20:3437-49.
55. Montague MJ, Li G, Gandolfi B, Khan R, Aken BL, Searle SM, et al. Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication. Proc Natl Acad Sci U S A. 2014;111:17230-5.
56. Biarnes X, Marchiori A, Giorgetti A, Lanzara C, Gasparini P, Carloni P, et al. Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. PLoS One. 2010;5, e12394.
57. Tan J, Abrol R, Trzaskowski B, Goddard 3rd WA. 3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). J Chem Inf Model. 2012;52:1875-85.
58. Marchiori A, Capece L, Giorgetti A, Gasparini P, Behrens M, Carloni P, et al. Coarse-grained/molecular mechanics of the TAS2R38 bitter taste receptor: experimentally-validated detailed structural prediction of agonist binding. PLoS One. 2013;8, e64675.
59. Wyrwicka W, Clemente CD. Acceptance of high concentration saccharin solutions by cats after hypothalamic lesions. Exp Neurol. 1973;40:367-76.
60. Li H, Pakstis AJ, Kidd JR, Kidd KK. Selection on the human bitter taste gene, TAS2R16, in Eurasian populations. Hum Biol. 2011;83:363-77.
61. Behrens M, Meyerhof W. Oral and extraoral bitter taste receptors. Results Probl Cell Differ. 2010;52:87-99.
62. Behrens M, Meyerhof W. Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav. 2011;105:4-13.