Amino acid derivatives as bitter taste receptor (T2R) blockers

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 25054-25066

  Pydi, Sai P ^a,b   Sobotkiewicz, Tyler ^a   Billakanti, Rohini ^a,b   Bhullar, Rajinder P ^a   Loewen, Michele C ^c   Chelikani, Prashen ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b MANITOBA INSTITUTE OF CHILD HEALTH   (Canada)

^c NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR MODELING; MUTAGENESIS;

AMINO ACID DERIVATIVES; BITTER COMPOUNDS; CONSTITUTIVELY ACTIVES; EXTRACELLULAR LOOP 2; INVERSE AGONISTS; PHARMACOLOGICAL CHARACTERIZATION; SITE DIRECTED MUTAGENESIS; TASTE RECEPTORS;

AMINO ACIDS;

4 AMINOBUTYRIC ACID; ALANINE; AMINO ACID DERIVATIVE; ASPARAGINE; LIGAND; LYSINE; NALPHA,NALPHA BIS(CARBOXYMETHYL)LYSINE; QUININE; THREONINE; UNCLASSIFIED DRUG; AMINO ACID; G PROTEIN COUPLED RECEPTOR; GABAERGIC RECEPTOR AFFECTING AGENT; PROTEIN BINDING; TASTE RECEPTORS, TYPE 2;

AMINO ACID ANALYSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL BINDING; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IC50; LIGAND BINDING; MEMBRANE POTENTIAL; MOLECULAR MODEL; PREDICTION; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; TASTE BUD; AGONISTS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; TASTE;

ALANINE; AMINO ACIDS; ASPARAGINE; BINDING SITES; GABA AGENTS; GAMMA-AMINOBUTYRIC ACID; HEK293 CELLS; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUININE; RECEPTORS, G-PROTEIN-COUPLED; TASTE; THREONINE;

EID: 84906987340     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.576975     Document Type: Article

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