Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration

Biotechnology Advances

Volumn 36, Issue 6, 2018, Pages 1768-1778

  Nabavi, Seyed Fazel ^a   Sureda, Antoni ^b   Dehpour, Ahmad Reza ^c,d   Shirooie, Samira ^e   Silva, Ana Sanches ^f,g   Devi, Kasi Pandima ^h   Ahmed, Touqeer ⁱ   Ishaq, Nafeesa ⁱ   Hashim, Rabia ⁱ   Sobarzo Sánchez, Eduardo ^j,k   Daglia, Maria ^l   Braidy, Nady ^m   Volpicella, Mariateresa ⁿ   Vacca, Rosa Anna ^o   Nabavi, Seyed Mohammad ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f National Institute for Agricultural and Veterinary Research (INIAV)   (Portugal)

^g UNIVERSITY OF PORTO   (Portugal)

^h ALAGAPPA UNIVERSITY   (India)

ⁱ NATIONAL UNIVERSITY OF SCIENCES AND TECHNOLOGY   (Pakistan)

^j UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^k UNIVERSIDAD CENTRAL DE CHILE   (Chile)

^l UNIVERSITY OF PAVIA   (Italy)

^m UNIVERSITY OF NEW SOUTH WALES   (Australia)

ⁿ UNIVERSITY OF BARI   (Italy)

^o CNR   (Italy)

more..

Author keywords

Alzheimer's disease; Autophagy; Neurodegeneration; Parkinson's disease; Polyphenols

Indexed keywords

BIOTECHNOLOGY;

ALZHEIMER'S DISEASE; AUTOPHAGY; NEURODEGENERATION; PARKINSON'S DISEASE; POLYPHENOLS;

NEURODEGENERATIVE DISEASES;

ANTIOXIDANT; MOLECULAR ANALYSIS; NERVOUS SYSTEM; NERVOUS SYSTEM DISORDER; NEUROLOGY; PATHOGEN; PHENOLIC COMPOUND; PHYTOCHEMISTRY;

PHYTOCHEMICAL; POLYPHENOL;

ANIMAL; AUTOPHAGY; DEGENERATIVE DISEASE; DRUG EFFECT; HUMAN; MOUSE;

ANIMALS; AUTOPHAGY; HUMANS; MICE; NEURODEGENERATIVE DISEASES; PHYTOCHEMICALS; POLYPHENOLS;

EID: 85039417063     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2017.12.001     Document Type: Review

References (143)

1. Achour, I., Arel-Dubeau, A.M., Renaud, J., Legrand, M., Attard, E., Germain, M., Martinoli, M.G., Oleuropein prevents neuronal death, mitigates mitochondrial superoxide production and modulates autophagy in a dopaminergic cellular model. Int. J. Mol. Sci., 17(8), 2016 (pii: E1293).
2. Ahmed, T., Javed, S., Javed, S., Tariq, A., Šamec, D., Tejada, S. et al., Resveratrol and Alzheimer's disease: mechanistic insights. Mol. Neurobiol. 54 (2017), 2622–2635.
3. Aires, V., Delmas, D., Common pathways in health benefit properties of RSV in cardiovascular diseases, cancers and degenerative pathologies. Curr. Pharm. Biotechnol. 16 (2015), 219–244.
4. Ajami, M., Pazoki-Toroudi, H., Amani, H., Nabavi, S.F., Braidy, N., Vacca, R.A. et al., Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols. Neurosci. Biobehav. Rev. 73 (2017), 39–47.
5. Alegre-Abarrategui, J., Wade-Martins, R., Parkinson disease, LRRK2 and the endocytic-autophagic pathway. Autophagy 5 (2009), 1208–1210.
6. Anand, P., Kunnumakkara, A.B., Newman, R.A., Aggarwal, B.B., Bioavailability of curcumin: problems and promises. Mol. Pharm. 4 (2007), 807–818.
7. Atwal, R.S., Truant, R., A stress sensitive ER membrane-association domain in huntingtin protein defines a potential role for huntingtin in the regulation of autophagy. Autophagy 4 (2008), 91–93.
8. Bhullar, K.S., Rupasinghe, H., Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxidative Med. Cell. Longev., 2013, 2013, 891748.
9. Bieschke, J., Russ, J., Friedrich, R.P., Ehrnhoefer, D.E., Wobst, H., Neugebauer, K. et al., EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity. Proc. Natl. Acad. Sci. 107 (2010), 7710–7715.
10. Boland, B., Kumar, A., Lee, S., Platt, F.M., Wegiel, J., Yu, W.H. et al., Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J. Neurosci. 28 (2008), 6926–6937.
11. Caruana, M., Vassallo, N., Tea polyphenols in Parkinson's disease. Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases, 2015, Springer, 117–137.
12. Caruana, M., Cauchi, R., Vassallo, N., Putative role of red wine polyphenols against brain pathology in Alzheimer's and Parkinson's disease. Front. Nutr., 3, 2016, 31.
13. Casamenti, F., Stefani, M., Olive polyphenols: new promising agents to combat aging-associated neurodegeneration. Expert Rev. Neurother. 17 (2017), 345–358.
14. Cattaneo, E., Zuccato, C., Tartari, M., Normal huntingtin function: an alternative approach to Huntington's disease. Nat. Rev. Neurosci. 6 (2005), 919–930.
15. Checkoway, H., Powers, K., Smith-Weller, T., Franklin, G.M., Longstreth, W. Jr., Swanson, P.D., Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intake. Am. J. Epidemiol. 155 (2002), 732–738.
16. Chen, H.Y., White, E., Role of autophagy in cancer prevention. Cancer Prev. Res. 4 (2011), 973–983.
17. Chen, W.W., Zhang, X., Huang, W.J., Role of neuroinflammation in neurodegenerative diseases. Mol. Med. Rep. 13 (2016), 3391–3396.
18. Choi, J., Park, S., Biering, S.B., Selleck, E., Liu, C.Y., Zhang, X. et al., The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. Immunity 40 (2014), 924–935.
19. Ciechanover, A., Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat. Rev. Mol. Cell Biol. 6 (2005), 79–87.
20. Cuervo, A.M., Stefanis, L., Fredenburg, R., Lansbury, P.T., Sulzer, D., Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy. Science 305 (2004), 1292–1295.
21. D'Archivio, M., Filesi, C., Varì R., Scazzocchio, B., Masella, R., Bioavailability of the polyphenols: status and controversies. Int. J. Mol. Sci. 11 (2010), 1321–1342.
22. Dash, S., Chava, S., Aydin, Y., Chandra, P.K., Ferraris, P., Chen, W. et al., Hepatitis C virus infection induces autophagy as a prosurvival mechanism to alleviate hepatic ER-stress response. Viruses, 8, 2016, 150.
23. Davies, S.W., Turmaine, M., Cozens, B.A., DiFiglia, M., Sharp, A.H., Ross, C.A. et al., Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90 (1997), 537–548.
24. Degenhardt, K., Mathew, R., Beaudoin, B., Bray, K., Anderson, D., Chen, G. et al., Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10 (2006), 51–64.
25. Delgado, M.A., Elmaoued, R.A., Davis, A.S., Kyei, G., Deretic, V., Toll-like receptors control autophagy. EMBO J. 27 (2008), 1110–1121.
26. Deng, Y.N., Shi, J., Liu, J., Qu, Q.M., Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem. Int. 63:1 (2013), 1–9.
27. Deretic, V., Saitoh, T., Akira, S., Autophagy in infection, inflammation, and immunity. Nat. Rev. Immunol. 13 (2013), 722–733.
28. Dubner, L., Wang, J., Ho, L., Ward, L., Pasinetti, G.M., Recommendations for development of new standardized forms of cocoa breeds and cocoa extract processing for the prevention of Alzheimer's disease: role of cocoa in promotion of cognitive resilience and healthy brain aging. J. Alzheimers Dis. 48 (2015), 879–889.
29. Ebrahimi, A., Schluesener, H., Natural polyphenols against neurodegenerative disorders: potentials and pitfalls. Ageing Res. Rev. 11 (2012), 329–345.
30. Ehrnhoefer, D.E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R. et al., EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat. Struct. Mol. Biol. 15 (2008), 558–566.
31. Esatbeyoglu, T., Huebbe, P., Ernst, I., Chin, D., Wagner, A.E., Rimbach, G., Curcumin-from molecule to biological function. Angew. Chem. Int. Ed. Engl. 51 (2012), 5308–5332.
32. Esler, W.P., Wolfe, M.S., A portrait of Alzheimer secretases—new features and familiar faces. Science 293 (2001), 1449–1454.
33. Filomeni, G., Graziani, I., De Zio, D., Dini, L., Centonze, D., Rotilio, G. et al., Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol. Aging 33:4 (2012), 767–785.
34. Frake, R.A., Ricketts, T., Menzies, F.M., Rubinsztein, D.C., Autophagy and neurodegeneration. J. Clin. Invest. 125 (2015), 65–74.
35. Friedman, L.G., Qureshi, Y.H., Yu, W.H., Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease. Neurotherapeutics 12 (2015), 94–108.
36. Ganguli, M., Chandra, V., Kamboh, M.I., Johnston, J.M., Dodge, H.H., Thelma, B. et al., Apolipoprotein E polymorphism and Alzheimer disease: the indo-US cross-national dementia study. Arch. Neurol. 57 (2000), 824–830.
37. Ghavami, S., Shojaei, S., Yeganeh, B., Ande, S.R., Jangamreddy, J.R., Mehrpour, M. et al., Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog. Neurobiol. 112 (2014), 24–49.
38. Giunta, B., Hou, H., Zhu, Y., Salemi, J., Ruscin, A., Shytle, R.D. et al., Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. Neurosci. Lett. 471 (2010), 134–138.
39. Goyarzu, P., Malin, D.H., Lau, F.C., Taglialatela, G., Moon, W.D., Jennings, R. et al., Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr. Neurosci. 7 (2004), 75–83.
40. Grossi, C., Rigacci, S., Ambrosini, S., Dami, T.E., Luccarini, I., Traini, C. et al., The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology. PLoS One, 8, 2013, e71702.
41. Gusdon, A.M., Zhu, J., Van Houten, B., Chu, C.T., ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol. Dis. 45 (2012), 962–972.
42. Hajieva, P., The effect of polyphenols on protein degradation pathways: implications for neuroprotection. Molecules, 22, 2017, 159.
43. Harada, M., Kan, Y., Naoki, H., Fukui, Y., Kageyama, N., Nakai, M. et al., Identification of the major antioxidative metabolites in biological fluids of the rat with ingested (+)-catechin and (−)-epicatechin. Biosci. Biotechnol. Biochem. 63 (1999), 973–977.
44. Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002), 353–356.
45. Hasima, N., Ozpolat, B., Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell Death Dis., 5, 2014, e1509.
46. Hattiangady, B., Shetty, A.K., Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy. Hippocampus 20:1 (2010), 97–112.
47. Heiseke, A., Aguib, Y., Schatzl, H.M., Autophagy, prion infection and their mutual interactions. Curr. Issues Mol. Biol. 12:2 (2010), 87–97.
48. Hsu, P., Shi, Y., Regulation of autophagy by mitochondrial phospholipids in health and diseases. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1862 (2017), 114–129.
49. Huang, C.C., Faber, P.W., Persichetti, F., Mittal, V., Vonsattel, J.P., MacDonald, M.E. et al., Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins. Somat. Cell Mol. Genet. 24 (1998), 217–233.
50. Huang, C., Yitzhaki, S., Perry, C.N., Liu, W., Giricz, Z., Mentzer, R.M. et al., Autophagy induced by ischemic preconditioning is essential for cardioprotection. J. Cardiovasc. Transl. Res. 3 (2010), 365–373.
51. Jaroonwitchawan, T., Chaicharoenaudomrung, N., Namkaew, J., Noisa, P., Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy. Neurosci. Lett. 636 (2017), 40–47.
52. Joseph, J.A., Shukitt-Hale, B., Denisova, N.A., Bielinski, D., Martin, A., McEwen, J.J. et al., Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 19 (1999), 8114–8121.
53. Koh, S.H., Kim, S.H., Kwon, H., Park, Y., Kim, K.S., Song, C.W. et al., Epigallocatechin gallate protects nerve growth factor differentiated PC12 cells from oxidative-radical-stress-induced apoptosis through its effect on phosphoinositide 3-kinase/Akt and glycogen synthase kinase-3. Mol. Brain Res. 118 (2003), 72–81.
54. Kovacs, G.G., Budka, H., Prion diseases: from protein to cell pathology. Am. J. Pathol. 172 (2008), 555–565.
55. Kroemer, G., Levine, B., Autophagic cell death: the story of a misnomer. Nat. Rev. Mol. Cell Biol., 9, 2008, 1004.
56. Kroemer, G., Mariño, G., Levine, B., Autophagy and the integrated stress response. Mol. Cell 40 (2010), 280–293.
57. Kurz, T., Eaton, J.W., Brunk, U.T., The role of lysosomes in iron metabolism and recycling. Int. J. Biochem. Cell Biol. 43 (2011), 1686–1697.
58. Lanzillotta, A., Porrini, V., Bellucci, A., Benarese, M., Branca, C., Parrella, E. et al., NF-κB in innate neuroprotection and age-related neurodegenerative diseases. Front. Neurol., 6, 2015, 98.
59. Laplante, M., Sabatini, D.M., mTOR signaling in growth control and disease. Cell 149 (2012), 274–293.
60. Lee, S.Y., Lee, J.W., Lee, H., Yoo, H.S., Yun, Y.P., Oh, K.W. et al., Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms. Mol. Brain Res. 140 (2005), 45–54.
61. Lee, J.H., Yu, W.H., Kumar, A., Lee, S., Mohan, P.S., Peterhoff, C.M. et al., Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141 (2010), 1146–1158.
62. Lee, J.H., Moon, J.H., Kim, S.W., Jeong, J.K., Nazim, U.M., Lee, Y.J. et al., EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells. Oncotarget 6:12 (2015), 9701–9717.
63. Levites, Y., Amit, T., Youdim, M.B., Mandel, S., Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (−)-epigallocatechin 3-gallate neuroprotective action. J. Biol. Chem. 277 (2002), 30574–30580.
64. Li, J.Q., Tan, L., Yu, J.T., The role of the LRRK2 gene in parkinsonism. Mol. Neurodegener., 9, 2014, 7.
65. Li, Q., Liu, Y., Sun, M., Autophagy and Alzheimer's disease. Cell. Mol. Neurobiol. 37 (2017), 377–388.
66. Li, P., Ma, K., Wu, H.Y., Wu, Y.P., Li, B.X., Isoflavones induce BEX2-dependent autophagy to prevent ATR-induced neurotoxicity in SH-SY5Y cells. Cell. Physiol. Biochem. 43:5 (2017), 1866–1879.
67. Libro, R., Giacoppo, S., Rajan, T.S., Bramanti, P., Mazzon, E., Natural phytochemicals in the treatment and prevention of dementia: an overview. Molecules, 21, 2016, 518.
68. Lin, T.K., Chen, S.D., Chuang, Y.C., Lin, H.Y., Huang, C.R., Chuang, J.H. et al., Resveratrol partially prevents rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through induction of heme oxygenase-1 dependent autophagy. Int. J. Mol. Sci. 15:1 (2014), 1625–1646.
69. Lippai, M., Szatmári, Z., Autophagy—from molecular mechanisms to clinical relevance. Cell Biol. Toxicol. 33 (2017), 145–168.
70. Liu, W.J., Ye, L., Huang, W.F., Guo, L.J., Xu, Z.G., Wu, H.L. et al., p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation. Cell. Mol. Biol. Lett., 21, 2016, 29.
71. Lynch-Day, M.A., Mao, K., Wang, K., Zhao, M., Klionsky, D.J., The role of autophagy in Parkinson's disease. Cold Spring Harb. Perspect. Med., 2, 2012, a009357.
72. Macedo, D., Tavares, L., McDougall, G.J., Vicente Miranda, H., Stewart, D., Ferreira, R.B. et al., (Poly) phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy. Hum. Mol. Genet. 24 (2014), 1717–1732.
73. Manach, C., Scalbert, A., Morand, C., Rémésy, C., Jiménez, L., Polyphenols: food sources and bioavailability. Am. J. Clin. Nutr. 79 (2004), 727–747.
74. Mancias, J.D., Wang, X., Gygi, S.P., Harper, J.W., Kimmelman, A.C., Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509 (2014), 105–109.
75. Martinez-Vicente, M., Talloczy, Z., Kaushik, S., Massey, A.C., Mazzulli, J., Mosharov, E.V. et al., Dopamine-modified α-synuclein blocks chaperone-mediated autophagy. J. Clin. Invest. 118 (2008), 777–788.
76. Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S. et al., Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat. Neurosci. 13 (2010), 567–576.
77. Mathew, R., Kongara, S., Beaudoin, B., Karp, C.M., Bray, K., Degenhardt, K. et al., Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 21 (2007), 1367–1381.
78. Mazzanti, G., Di Giacomo, S., Curcumin and resveratrol in the management of cognitive disorders: what is the clinical evidence?. Molecules, 21, 2016, 1243.
79. McDougall, G.J., Phenolic-enriched foods: sources and processing for enhanced health benefits. Proc. Nutr. Soc. 76 (2017), 163–171.
80. Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J., Autophagy fights disease through cellular self-digestion. Nature, 451, 2008, 1069.
81. Molino, S., Dossena, M., Buonocore, D., Ferrari, F., Venturini, L., Ricevuti, G. et al., Polyphenols in dementia: from molecular basis to clinical trials. Life Sci. 161 (2016), 69–77.
82. Muller, C., Salvayre, R., Nègre-Salvayre, A., Vindis, C., Oxidized LDLs trigger endoplasmic reticulum stress and autophagy: prevention by HDLs. Autophagy 7 (2011), 541–543.
83. Nardacci, R., Ciccosanti, F., Marsella, C., Ippolito, G., Piacentini, M., Fimia, G.M., Role of autophagy in HIV infection and pathogenesis. J. Intern. Med. 281 (2017), 422–432.
84. Nijholt, D.A., De Kimpe, L., Elfrink, H.L., Hoozemans, J.J., Scheper, W., Removing protein aggregates: the role of proteolysis in neurodegeneration. Curr. Med. Chem. 18 (2011), 2459–2476.
85. de Oliveira, M.R., Nabavi, S.F., Daglia, M., Rastrelli, L., Nabavi, S.M., Epigallocatechin gallate and mitochondria—a story of life and death. Pharmacol. Res. 104 (2016), 70–85.
86. Omar, S.H., Scott, C.J., Hamlin, A.S., Obied, H.K., The protective role of plant biophenols in mechanisms of Alzheimer's disease. J. Nutr. Biochem. 47 (2017), 1–20.
87. Ono, K., Hasegawa, K., Naiki, H., Yamada, M., Curcumin has potent anti-amyloidogenic effects for Alzheimer's β-amyloid fibrils in vitro. J. Neurosci. Res. 75 (2004), 742–750.
88. Ouyang, L., Zhang, L., Liu, B., Autophagy pathways and key drug targets in Parkinson's disease. Acta Pharm. Sin., 51, 2016, 9.
89. Pallauf, K., Rimbach, G., Autophagy, polyphenols and healthy ageing. Ageing Res. Rev. 12 (2013), 237–252.
90. Palop, J.J., Mucke, L., Epilepsy and cognitive impairments in Alzheimer disease. Arch. Neurol. 66:4 (2009), 435–440.
91. Pandareesh, M., Mythri, R., Bharath, M.S., Bioavailability of dietary polyphenols: factors contributing to their clinical application in CNS diseases. Neurochem. Int. 89 (2015), 198–208.
92. Pandey, K.B., Rizvi, S.I., Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Med. Cell. Longev. 2:5 (2009), 270–278.
93. Pérez-Hernández, J., Zaldívar-Machorro, V.J., Villanueva-Porras, D., Vega-Ávila, E., Chavarría, A., A potential alternative against neurodegenerative diseases: phytodrugs. Oxidative Med. Cell. Longev., 2016, 2016, 8378613.
94. Pineda-Ramírez, N., Gutiérrez Aguilar, G.F., Espinoza-Rojo, M., Aguilera, P., Current evidence for AMPK activation involvement on resveratrol-induced neuroprotection in cerebral ischemia. Nutr. Neurosci., 2017, 1–19.
95. Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J. et al., Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?. Folia Neuropathol. 53 (2015), 89–99.
96. Polymeropoulos, M.H., Lavedan, C., Leroy, E., Ide, S.E., Dehejia, A., Dutra, A. et al., Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276 (1997), 2045–2047.
97. Poulose, S.M., Fisher, D.R., Bielinski, D.F., Gomes, S.M., Rimando, A.M., Schauss, A.G. et al., Restoration of stressor-induced calcium dysregulation and autophagy inhibition by polyphenol-rich açaí (Euterpe spp.) fruit pulp extracts in rodent brain cells in vitro. Nutrition 30 (2014), 853–862.
98. Pu, F., Mishima, K., Irie, K., Motohashi, K., Tanaka, Y., Orito, K. et al., Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats. J. Pharmacol. Sci. 104 (2007), 329–334.
99. Rahimifard, M., Maqbool, F., Moeini-Nodeh, S., Niaz, K., Abdollahi, M., Braidy, N. et al., Targeting the TLR4 signaling pathway by polyphenol: a novel therapeutic strategy for neuroinflammation. Ageing Res. Rev. 36 (2017), 11–19.
100. Regitz, C., Marie Dußling, L., Wenzel, U., Amyloid-beta (Aβ1–42)-induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways. Mol. Nutr. Food Res. 58 (2014), 1931–1940.
101. Rhein, V., Song, X., Wiesner, A., Ittner, L.M., Baysang, G., Meier, F. et al., Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice. Proc. Natl. Acad. Sci. 106 (2009), 20057–20062.
102. Rigacci, S., Miceli, C., Nediani, C., Berti, A., Cascella, R., Pantano, D. et al., Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight. Oncotarget, 6, 2015, 35344.
103. Rubinsztein, D.C., Carmichael, J., Huntington's disease: molecular basis of neurodegeneration. Expert Rev. Mol. Med. 5 (2003), 1–21.
104. Rubinsztein, D.C., Codogno, P., Levine, B., Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov., 11, 2012, 709.
105. Sarkar, S., Regulation of Autophagy by mTOR-Dependent and mTOR-Independent Pathways: Autophagy Dysfunction in Neurodegenerative Diseases and Therapeutic Application of Autophagy Enhancers. 2013, Portland Press Limited.
106. Selkoe, D.J., Alzheimer's disease is a synaptic failure. Science 298 (2002), 789–791.
107. Serpell, L.C., Smith, J.M., Direct visualisation of the β-sheet structure of synthetic Alzheimer's amyloid. J. Mol. Biol. 299 (2000), 225–231.
108. Shaid, S., Brandts, C., Serve, H., Dikic, I., Ubiquitination and selective autophagy. Cell Death Differ., 20, 2013, 21.
109. Shibata, M., Lu, T., Furuya, T., Degterev, A., Mizushima, N., Yoshimori, T. et al., Regulation of intracellular accumulation of mutant huntingtin by Beclin 1. J. Biol. Chem. 281 (2006), 14474–14485.
110. Shintani, T., Klionsky, D.J., Autophagy in health and disease: a double-edged sword. Science 306 (2004), 990–995.
111. Singh, N.A., Mandal, A.K.A., Khan, Z.A., Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG). Nutr. J., 15, 2016, 60.
112. Stefanis, L., Larsen, K.E., Rideout, H.J., Sulzer, D., Greene, L.A., Expression of A53T mutant but not wild-type α-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death. J. Neurosci. 21 (2001), 9549–9560.
113. Subramaniam, S., Sixt, K.M., Barrow, R., Snyder, S.H., Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity. Science 324 (2009), 1327–1330.
114. Sun, D., Li, N., Zhang, W., Zhao, Z., Mou, Z., Huang, D. et al., Design of PLGA-functionalized quercetin nanoparticles for potential use in Alzheimer's disease. Colloids Surf. B Biointerfaces 148 (2016), 116–129.
115. Szot, P., Common factors among Alzheimer's disease, Parkinson's disease, and epilepsy: possible role of the noradrenergic nervous system. Epilepsia 53:Suppl. 1 (2012), 61–66.
116. Tanida, I., Ueno, T., Kominami, E., LC3 and autophagy. Methods Mol. Biol. 445 (2008), 77–88.
117. Tsao, R., Chemistry and biochemistry of dietary polyphenols. Nutrients 2 (2010), 1231–1246.
118. Ullah, F., Liang, A., Rangel, A., Gyengesi, E., Niedermayer, G., Münch, G., High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation. Arch. Toxicol. 91:4 (2017), 1623–1634.
119. Vacca, R.A., Valenti, D., Caccamese, S., Daglia, M., Braidy, N., Nabavi, S.M., Plant polyphenols as natural drugs for the management of down syndrome and related disorders. Neurosci. Biobehav. Rev. 71 (2016), 865–877.
120. Vafeiadou, K., Vauzour, D., Lee, H.Y., Rodriguez-Mateos, A., Williams, R.J., Spencer, J.P., The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch. Biochem. Biophys. 484 (2009), 100–109.
121. Valenti, D., De Rasmo, D., Signorile, A., Rossi, L., de Bari, L., Scala, I. et al., Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome. Biochim. Biophys. Acta Mol. Basis Dis. 1832 (2013), 542–552.
122. Valenti, D., Braidy, N., De Rasmo, D., Signorile, A., Rossi, L., Atanasov, A.G. et al., Mitochondria as pharmacological targets in down syndrome. Free Radic. Biol. Med., 2017, 10.1016/j.freeradbiomed.2017.08.014.
123. Vidoni, C., Secomandi, E., Castiglioni, A., Melone, M.A.B., Isidoro, C., Resveratrol protects neuronal-like cells expressing mutant huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation. Neurochem. Int., 2017, 10.1016/j.neuint.2017.05.013.
124. Vonsattel, J.P., Myers, R.H., Stevens, T.J., Ferrante, R.J., Bird, E.D., Richardson, E.P., Neuropathological classification of Huntington's disease. J. Neuropathol. Exp. Neurol. 44 (1985), 559–577.
125. Walker, L.C., LeVine, H., The cerebral proteopathies. Mol. Neurobiol., 21, 2000, 83.
126. Wang, Y., Chang, C.F., Chou, J., Chen, H.L., Deng, X., Harvey, B.K. et al., Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Exp. Neurol. 193 (2005), 75–84.
127. Wang, S.F., Wu, M.Y., Cai, C.Z., Li, M., Lu, J.H., Autophagy modulators from traditional Chinese medicine: mechanisms and therapeutic potentials for cancer and neurodegenerative diseases. J. Ethnopharmacol. 194 (2016), 861–876.
128. Wang, J., Liu, Y., Li, X., Zeng, X.C., Li, J., Zhou, J. et al., Curcumin protects neuronal cells against status-epilepticus-induced hippocampal damage through induction of autophagy and inhibition of necroptosis. Can. J. Physiol. Pharmacol. 95:5 (2017), 501–509.
129. Weckman, A., Rotondo, F., Di Ieva, A., Syro, L.V., Butz, H., Cusimano, M.D. et al., Autophagy in endocrine tumors. Endocr. Relat. Cancer 22 (2015), R205–R218.
130. Wenzel, E., Soldo, T., Erbersdobler, H., Somoza, V., Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol. Nutr. Food Res. 49 (2005), 482–494.
131. Winslow, A.R., Chen, C.W., Corrochano, S., Acevedo-Arozena, A., Gordon, D.E., Peden, A.A. et al., α-Synuclein impairs macroautophagy: implications for Parkinson's disease. J. Cell Biol. 190 (2010), 1023–1037.
132. Winter, A.N., Ross, E.K., Khatter, S., Miller, K., Linseman, D.A., Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress. Free Radic. Biol. Med. 103 (2017), 23–34.
133. Wong, E., Cuervo, A.M., Autophagy gone awry in neurodegenerative diseases. Nat. Neurosci. 13 (2010), 805–811.
134. Wu, Y., Li, X., Zhu, J.X., Xie, W., Le, W., Fan, Z. et al., Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease. Neurosignals 19:3 (2011), 163–174.
135. Wu, X., He, L., Cai, Y., Zhang, G., He, Y., Zhang, Z. et al., Induction of autophagy contributes to the myocardial protection of valsartan against ischemia-reperfusion injury. Mol. Med. Rep. 8 (2013), 1824–1830.
136. Wu, L.H., Lin, C., Lin, H.Y., Liu, Y.S., Wu, C.Y.J., Tsai, C.F. et al., Naringenin suppresses neuroinflammatory responses through inducing suppressor of cytokine signaling 3 expression. Mol. Neurobiol. 53 (2016), 1080–1091.
137. Xie, Z., Klionsky, D.J., Autophagosome formation: core machinery and adaptations. Nat. Cell Biol. 9 (2007), 1102–1109.
138. Xilouri, M., Stefanis, L., Autophagy in the central nervous system: implications for neurodegenerative disorders. CNS Neurol. Disord. Drug Targets 9 (2010), 701–719.
139. Xilouri, M., Stefanis, L., Chaperone mediated autophagy to the rescue: a new-fangled target for the treatment of neurodegenerative diseases. Mol. Cell. Neurosci. 66 (2015), 29–36.
140. Yallapu, M.M., Jaggi, M., Chauhan, S.C., Poly (β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells. Macromol. Biosci. 10 (2010), 1141–1151.
141. Yao, H., Zhao, D., Khan, S.H., Yang, L., Role of autophagy in prion protein-induced neurodegenerative diseases. Acta Biochim. Biophys. Sin. 45 (2013), 494–502.
142. Zare-shahabadi, A., Masliah, E., Johnson, G.V., Rezaei, N., Autophagy in Alzheimer's disease. Rev. Neurosci. 26 (2015), 385–395.
143. Zhao, B., Natural antioxidants protect neurons in Alzheimer's disease and Parkinson's disease. Neurochem. Res. 34 (2009), 630–638.