SCOPUS 정보 검색 플랫폼

Journal of Cell Biology

Volumn 216, Issue 11, 2017, Pages 3441-3452

Crossed wires: 3D genome misfolding in human disease

(2) Norton, Heidi K a Phillips Cremins, Jennifer E a,b

a UNIVERSITY OF PENNSYLVANIA (United States)

b UNIVERSITY OF PENNSYLVANIA (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COHESIN; TRANSCRIPTION FACTOR CTCF; ZINC FINGER PROTEIN; PROTEIN BINDING;

BINDING SITE; CARCINOGENESIS; CHROMATIN; CHROMOSOME REARRANGEMENT; COLORECTAL CANCER; CONGENITAL DISORDER; CONSENSUS SEQUENCE; DE LANGE SYNDROME; DNA METHYLATION; ENHANCER REGION; GENE DELETION; GENE EXPRESSION; GENE TRANSLOCATION; GENOME MISFOLDING; GENOMICS; HETEROZYGOSITY; HUMAN; HUMAN GENOME; LAMINOPATHY; LIMB MALFORMATION; MISSENSE MUTATION; NONHUMAN; NUCLEAR LAMINA; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; ANIMAL; CELL NUCLEUS; CONFORMATION; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HUMAN CHROMOSOME; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY; PHENOTYPE;

ANIMALS; CCCTC-BINDING FACTOR; CELL NUCLEUS; CHROMOSOMES, HUMAN; ENHANCER ELEMENTS, GENETIC; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; MUTATION; NEOPLASMS; NUCLEIC ACID CONFORMATION; PHENOTYPE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; ZINC FINGERS;

EID: 85032928360 PISSN: 00219525 EISSN: 15408140 Source Type: Journal
DOI: 10.1083/jcb.201611001 Document Type: Review

Times cited : (38)

References (126)

1
- 84871208196
- Self-organization of domain structures by DNA-loop-extruding enzymes
- Alipour, E., and J.F. Marko. 2012. Self-organization of domain structures by DNA-loop-extruding enzymes. Nucleic Acids Res. 40:11202-11212. http://dx.doi.org /10.1093 /nar /gks925
- (2012) Nucleic Acids Res , vol.40 , pp. 11202-11212
- Alipour, E.¹ Marko, J.F.²

2
- 84908110204
- Mapping the Shh long-range regulatory domain
- Anderson, E., P.S. Devenney, R.E. Hill, and L.A. Lettice. 2014. Mapping the Shh long-range regulatory domain. Development. 141:3934-3943. http://dx.doi.org /10.1242 /dev.108480
- (2014) Development , vol.141 , pp. 3934-3943
- Anderson, E.¹ Devenney, P.S.² Hill, R.E.³ Lettice, L.A.⁴

3
- 0347988236
- Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
- Aten, J.A., J. Stap, P.M. Krawczyk, C.H. van Oven, R.A. Hoebe, J. Essers, and R. Kanaar. 2004. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science. 303:92-95. http://dx.doi.org /10.1126 /science.1088845
- (2004) Science , vol.303 , pp. 92-95
- Aten, J.A.¹ Stap, J.² Krawczyk, P.M.³ van Oven, C.H.⁴ Hoebe, R.A.⁵ Essers, J.⁶ Kanaar, R.⁷

4
- 0033578616
- Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence
- Awad, T.A., J. Bigler, J.E. Ulmer, Y.J. Hu, J.M. Moore, M. Lutz, P.E. Neiman, S.J. Collins, R. Renkawitz, V.V. Lobanenkov, and G.N. Filippova. 1999. Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence. J. Biol. Chem. 274:27092-27098. http://dx.doi.org /10.1074 /jbc.274.38.27092
- (1999) J. Biol. Chem , vol.274 , pp. 27092-27098
- Awad, T.A.¹ Bigler, J.² Ulmer, J.E.³ Hu, Y.J.⁴ Moore, J.M.⁵ Lutz, M.⁶ Neiman, P.E.⁷ Collins, S.J.⁸ Renkawitz, R.⁹ Lobanenkov, V.V.¹⁰ Filippova, G.N.¹¹

5
- 84896721518
- Mechanisms of cohesinmediated gene regulation and lessons learned from cohesinopathies
- Ball, A.R. Jr., Y.Y. Chen, and K. Yokomori. 2014. Mechanisms of cohesinmediated gene regulation and lessons learned from cohesinopathies. Biochim. Biophys. Acta. 1839:191-202. http://dx.doi.org /10.1016 /j.bbagrm.2013.11.002
- (2014) Biochim. Biophys. Acta , vol.1839 , pp. 191-202
- Ball, A.R.¹ Chen, Y.Y.² Yokomori, K.³

6
- 84975046385
- CRI SPR/Cas9 genome editing throws descriptive 3-D genome folding studies for a loop
- Beagan, J.A., and J.E. Phillips-Cremins. 2016. CRI SPR/Cas9 genome editing throws descriptive 3-D genome folding studies for a loop. Wiley Interdiscip. Rev. Syst. Biol. Med. 8:286-299. http://dx.doi.org /10.1002 / wsbm.1338
- (2016) Wiley Interdiscip. Rev. Syst. Biol. Med , vol.8 , pp. 286-299
- Beagan, J.A.¹ Phillips-Cremins, J.E.²

7
- 0034713375
- Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
- Bell, A.C., and G. Felsenfeld. 2000. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature. 405:482-485. http://dx.doi.org /10.1038 /35013100
- (2000) Nature , vol.405 , pp. 482-485
- Bell, A.C.¹ Felsenfeld, G.²

8
- 33646729244
- Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations
- Branco, M.R., and A. Pombo. 2006. Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations. PLoS Biol. 4:e138. http://dx.doi.org /10.1371 /journal.pbio.0040138
- (2006) PLoS Biol , vol.4
- Branco, M.R.¹ Pombo, A.²

9
- 0031029141
- Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF
- Burcin, M., R. Arnold, M. Lutz, B. Kaiser, D. Runge, F. Lottspeich, G.N. Filippova, V.V. Lobanenkov, and R. Renkawitz. 1997. Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. Mol. Cell. Biol. 17:1281-1288. http://dx.doi.org /10.1128 /MCB.17.3.1281
- (1997) Mol. Cell. Biol , vol.17 , pp. 1281-1288
- Burcin, M.¹ Arnold, R.² Lutz, M.³ Kaiser, B.⁴ Runge, D.⁵ Lottspeich, F.⁶ Filippova, G.N.⁷ Lobanenkov, V.V.⁸ Renkawitz, R.⁹

10
- 0036347096
- Life at the edge: The nuclear envelope and human disease
- Burke, B., and C.L. Stewart. 2002. Life at the edge: The nuclear envelope and human disease. Nat. Rev. Mol. Cell Biol. 3:575-585. http://dx.doi.org /10.1038 /nrm879
- (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 575-585
- Burke, B.¹ Stewart, C.L.²

11
- 75749103380
- Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes
- Capelson, M., Y. Liang, R. Schulte, W. Mair, U. Wagner, and M.W. Hetzer. 2010. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 140:372-383. http://dx.doi.org /10.1016 /j.cell.2009.12.054
- (2010) Cell , vol.140 , pp. 372-383
- Capelson, M.¹ Liang, Y.² Schulte, R.³ Mair, W.⁴ Wagner, U.⁵ Hetzer, M.W.⁶

12
- 0025223062
- Allelic loss of chromosomes 16q and 10q in human prostate cancer
- Carter, B.S., C.M. Ewing, W.S. Ward, B.F. Treiger, T.W. Aalders, J.A. Schalken, J.I. Epstein, and W.B. Isaacs. 1990. Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc. Natl. Acad. Sci. USA. 87:8751-8755. http://dx.doi.org /10.1073 /pnas.87.22.8751
- (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8751-8755
- Carter, B.S.¹ Ewing, C.M.² Ward, W.S.³ Treiger, B.F.⁴ Aalders, T.W.⁵ Schalken, J.A.⁶ Epstein, J.I.⁷ Isaacs, W.B.⁸

13
- 2442695407
- Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription
- Chambeyron, S., and W.A. Bickmore. 2004. Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. Genes Dev. 18:1119-1130. http://dx.doi.org /10.1101 /gad.292104
- (2004) Genes Dev , vol.18 , pp. 1119-1130
- Chambeyron, S.¹ Bickmore, W.A.²

14
- 84864063907
- Comprehensive identification and annotation of cell type-specific and ubiquitous CTCFbinding sites in the human genome
- Chen, H., Y. Tian, W. Shu, X. Bo, and S. Wang. 2012. Comprehensive identification and annotation of cell type-specific and ubiquitous CTCFbinding sites in the human genome. PLoS One. 7:e41374. http://dx.doi.org /10.1371 /journal.pone.0041374
- (2012) PLoS One , vol.7
- Chen, H.¹ Tian, Y.² Shu, W.³ Bo, X.⁴ Wang, S.⁵

15
- 44649117905
- Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
- Chen, X., H. Xu, P. Yuan, F. Fang, M. Huss, V.B. Vega, E. Wong, Y.L. Orlov, W. Zhang, J. Jiang, et al. 2008. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 133:1106-1117. http://dx.doi.org /10.1016 /j.cell.2008.04.043
- (2008) Cell , vol.133 , pp. 1106-1117
- Chen, X.¹ Xu, H.² Yuan, P.³ Fang, F.⁴ Huss, M.⁵ Vega, V.B.⁶ Wong, E.⁷ Orlov, Y.L.⁸ Zhang, W.⁹ Jiang, J.¹⁰

16
- 80053558376
- Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells
- Chiarle, R., Y. Zhang, R.L. Frock, S.M. Lewis, B. Molinie, Y.J. Ho, D.R. Myers, V.W. Choi, M. Compagno, D.J. Malkin, et al. 2011. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 147:107-119. http://dx.doi.org /10.1016 /j.cell.2011.07.049
- (2011) Cell , vol.147 , pp. 107-119
- Chiarle, R.¹ Zhang, Y.² Frock, R.L.³ Lewis, S.M.⁴ Molinie, B.⁵ Ho, Y.J.⁶ Myers, D.R.⁷ Choi, V.W.⁸ Compagno, M.⁹ Malkin, D.J.¹⁰

17
- 84884997982
- Emerging landscape of oncogenic signatures across human cancers
- Ciriello, G., M.L. Miller, B.A. Aksoy, Y. Senbabaoglu, N. Schultz, and C. Sander. 2013. Emerging landscape of oncogenic signatures across human cancers. Nat. Genet. 45:1127-1133. http://dx.doi.org /10.1038 /ng.2762
- (2013) Nat. Genet , vol.45 , pp. 1127-1133
- Ciriello, G.¹ Miller, M.L.² Aksoy, B.A.³ Senbabaoglu, Y.⁴ Schultz, N.⁵ Sander, C.⁶

18
- 0035316574
- Chromosome territories, nuclear architecture and gene regulation in mammalian cells
- Cremer, T., and C. Cremer. 2001. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat. Rev. Genet. 2:292-301. http://dx.doi.org /10.1038 /35066075
- (2001) Nat. Rev. Genet , vol.2 , pp. 292-301
- Cremer, T.¹ Cremer, C.²

19
- 0033553877
- Differences in the localization and morphology of chromosomes in the human nucleus
- Croft, J.A., J.M. Bridger, S. Boyle, P. Perry, P. Teague, and W.A. Bickmore. 1999. Differences in the localization and morphology of chromosomes in the human nucleus. J. Cell Biol. 145:1119-1131. http://dx.doi.org /10.1083 /jcb.145.6.1119
- (1999) J. Cell Biol , vol.145 , pp. 1119-1131
- Croft, J.A.¹ Bridger, J.M.² Boyle, S.³ Perry, P.⁴ Teague, P.⁵ Bickmore, W.A.⁶

20
- 60149095014
- Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains
- Cuddapah, S., R. Jothi, D.E. Schones, T.-Y. Roh, K. Cui, and K. Zhao. 2009. Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res. 19:24-32. http://dx.doi.org /10.1101 /gr.082800.108
- (2009) Genome Res , vol.19 , pp. 24-32
- Cuddapah, S.¹ Jothi, R.² Schones, D.E.³ Roh, T.-Y.⁴ Cui, K.⁵ Zhao, K.⁶

21
- 84943358862
- Structural and functional diversity of topologically associating domains
- Dekker, J., and E. Heard. 2015. Structural and functional diversity of topologically associating domains. FEBS Lett. 589(20 Pt A):2877-2884. http://dx.doi.org /10.1016 /j.febslet.2015.08.044
- (2015) FEBS Lett , vol.589 , Issue.20 , pp. 2877-2884
- Dekker, J.¹ Heard, E.²

22
- 84878011578
- Exploring the threedimensional organization of genomes: Interpreting chromatin interaction data
- Dekker, J., M.A. Marti-Renom, and L.A. Mirny. 2013. Exploring the threedimensional organization of genomes: Interpreting chromatin interaction data. Nat. Rev. Genet. 14:390-403. http://dx.doi.org /10.1038 /nrg3454
- (2013) Nat. Rev. Genet , vol.14 , pp. 390-403
- Dekker, J.¹ Marti-Renom, M.A.² Mirny, L.A.³

23
- 84855297335
- A decade of 3C technologies: Insights into nuclear organization
- de Wit, E., and W. de Laat. 2012. A decade of 3C technologies: Insights into nuclear organization. Genes Dev. 26:11-24. http://dx.doi.org /10.1101 / gad.179804.111
- (2012) Genes Dev , vol.26 , pp. 11-24
- de Wit, E.¹ de Laat, W.²

24
- 84947765898
- CTCF binding polarity determines chromatin looping
- de Wit, E., E.S. Vos, S.J. Holwerda, C. Valdes-Quezada, M.J. Verstegen, H. Teunissen, E. Splinter, P.J. Wijchers, P.H. Krijger, and W. de Laat. 2015. CTCF binding polarity determines chromatin looping. Mol. Cell. 60:676-684. http://dx.doi.org /10.1016 /j.molcel.2015.09.023
- (2015) Mol. Cell , vol.60 , pp. 676-684
- de Wit, E.¹ Vos, E.S.² Holwerda, S.J.³ Valdes-Quezada, C.⁴ Verstegen, M.J.⁵ Teunissen, H.⁶ Splinter, E.⁷ Wijchers, P.J.⁸ Krijger, P.H.⁹ de Laat, W.¹⁰

25
- 34249777814
- Variation in FTO contributes to childhood obesity and severe adult obesity
- Dina, C., D. Meyre, S. Gallina, E. Durand, A. Körner, P. Jacobson, L.M.S. Carlsson, W. Kiess, V. Vatin, C. Lecoeur, et al. 2007. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39:724-726. http://dx.doi.org /10.1038 /ng2048
- (2007) Nat. Genet , vol.39 , pp. 724-726
- Dina, C.¹ Meyre, D.² Gallina, S.³ Durand, E.⁴ Körner, A.⁵ Jacobson, P.⁶ Carlsson, L.M.S.⁷ Kiess, W.⁸ Vatin, V.⁹ Lecoeur, C.¹⁰

26
- 79957654428
- The lamin protein family
- Dittmer, T.A., and T. Misteli. 2011. The lamin protein family. Genome Biol. 12:222. http://dx.doi.org /10.1186 /gb-2011-12-5-222
- (2011) Genome Biol , vol.12 , pp. 222
- Dittmer, T.A.¹ Misteli, T.²

27
- 84861095603
- Topological domains in mammalian genomes identified by analysis of chromatin interactions
- Dixon, J.R., S. Selvaraj, F. Yue, A. Kim, Y. Li, Y. Shen, M. Hu, J.S. Liu, and B. Ren. 2012. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature. 485:376-380. http://dx.doi.org /10.1038 /nature11082
- (2012) Nature , vol.485 , pp. 376-380
- Dixon, J.R.¹ Selvaraj, S.² Yue, F.³ Kim, A.⁴ Li, Y.⁵ Shen, Y.⁶ Hu, M.⁷ Liu, J.S.⁸ Ren, B.⁹

28
- 84913594397
- Genome editing The new frontier of genome engineering with CRI SPR-Cas9
- Doudna, J.A., and E. Charpentier. 2014. Genome editing. The new frontier of genome engineering with CRI SPR-Cas9. Science. 346:1258096. http:// dx.doi.org /10.1126 /science.1258096
- (2014) Science , vol.346
- Doudna, J.A.¹ Charpentier, E.²

29
- 84916880365
- Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes
- Dowen, J.M., Z.P. Fan, D. Hnisz, G. Ren, B.J. Abraham, L.N. Zhang, A.S. Weintraub, J. Schujiers, T.I. Lee, K. Zhao, and R.A. Young. 2014. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell. 159:374-387. http://dx.doi.org /10.1016 /j.cell.2014.09.030
- (2014) Cell , vol.159 , pp. 374-387
- Dowen, J.M.¹ Fan, Z.P.² Hnisz, D.³ Ren, G.⁴ Abraham, B.J.⁵ Zhang, L.N.⁶ Weintraub, A.S.⁷ Schujiers, J.⁸ Lee, T.I.⁹ Zhao, K.¹⁰ Young, R.A.¹¹

30
- 84868325694
- Cohesin regulates tissuespecific expression by stabilizing highly occupied cis-regulatory modules
- Faure, A.J., D. Schmidt, S. Watt, P.C. Schwalie, M.D. Wilson, H. Xu, R.G. Ramsay, D.T. Odom, and P. Flicek. 2012. Cohesin regulates tissuespecific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 22:2163-2175. http://dx.doi.org /10.1101 /gr.136507.111
- (2012) Genome Res , vol.22 , pp. 2163-2175
- Faure, A.J.¹ Schmidt, D.² Watt, S.³ Schwalie, P.C.⁴ Wilson, M.D.⁵ Xu, H.⁶ Ramsay, R.G.⁷ Odom, D.T.⁸ Flicek, P.⁹

31
- 0029929793
- An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
- Filippova, G.N., S. Fagerlie, E.M. Klenova, C. Myers, Y. Dehner, G. Goodwin, P.E. Neiman, S.J. Collins, and V.V. Lobanenkov. 1996. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol. Cell. Biol. 16:2802-2813. http://dx.doi.org /10.1128 /MCB.16.6.2802
- (1996) Mol. Cell. Biol , vol.16 , pp. 2802-2813
- Filippova, G.N.¹ Fagerlie, S.² Klenova, E.M.³ Myers, C.⁴ Dehner, Y.⁵ Goodwin, G.⁶ Neiman, P.E.⁷ Collins, S.J.⁸ Lobanenkov, V.V.⁹

32
- 0036141521
- Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity
- Filippova, G.N., C.-F. Qi, J.E. Ulmer, J.M. Moore, M.D. Ward, Y.J. Hu, D.I. Loukinov, E.M. Pugacheva, E.M. Klenova, P.E. Grundy, et al. 2002. Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. Cancer Res. 62:48-52
- (2002) Cancer Res , vol.62 , pp. 48-52
- Filippova, G.N.¹ Qi, C.-F.² Ulmer, J.E.³ Moore, J.M.⁴ Ward, M.D.⁵ Hu, Y.J.⁶ Loukinov, D.I.⁷ Pugacheva, E.M.⁸ Klenova, E.M.⁹ Grundy, P.E.¹⁰

33
- 84953924597
- Insulator dysfunction and oncogene activation in IDH mutant gliomas
- Flavahan, W.A., Y. Drier, B.B. Liau, S.M. Gillespie, A.S. Venteicher, A.O. Stemmer-Rachamimov, M.L. Suvà, and B.E. Bernstein. 2016. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature. 529:110-114. http://dx.doi.org /10.1038 /nature16490
- (2016) Nature , vol.529 , pp. 110-114
- Flavahan, W.A.¹ Drier, Y.² Liau, B.B.³ Gillespie, S.M.⁴ Venteicher, A.S.⁵ Stemmer-Rachamimov, A.O.⁶ Suvà, M.L.⁷ Bernstein, B.E.⁸

34
- 84956604089
- Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation
- Fraser, J., C. Ferrai, A.M. Chiariello, M. Schueler, T. Rito, G. Laudanno, M. Barbieri, B.L. Moore, D.C. Kraemer, S. Aitken, et al. FAN TOM Consortium. 2015. Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation. Mol. Syst. Biol. 11:852. http://dx.doi.org /10.15252 /msb.20156492
- (2015) Mol. Syst. Biol , vol.11 , pp. 852
- Fraser, J.¹ Ferrai, C.² Chiariello, A.M.³ Schueler, M.⁴ Rito, T.⁵ Laudanno, G.⁶ Barbieri, M.⁷ Moore, B.L.⁸ Kraemer, D.C.⁹ Aitken, S.¹⁰

35
- 34248594090
- A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
- Frayling, T.M., N.J. Timpson, M.N. Weedon, E. Zeggini, R.M. Freathy, C.M. Lindgren, J.R.B. Perry, K.S. Elliott, H. Lango, N.W. Rayner, et al. 2007. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 316:889-894. http://dx.doi.org /10.1126 /science.1141634
- (2007) Science , vol.316 , pp. 889-894
- Frayling, T.M.¹ Timpson, N.J.² Weedon, M.N.³ Zeggini, E.⁴ Freathy, R.M.⁵ Lindgren, C.M.⁶ Perry, J.R.B.⁷ Elliott, K.S.⁸ Lango, H.⁹ Rayner, N.W.¹⁰

36
- 83255165727
- High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
- Fudenberg, G., G. Getz, M. Meyerson, and L.A. Mirny. 2011. High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. Nat. Biotechnol. 29:1109-1113. http://dx.doi.org /10.1038 /nbt.2049
- (2011) Nat. Biotechnol , vol.29 , pp. 1109-1113
- Fudenberg, G.¹ Getz, G.² Meyerson, M.³ Mirny, L.A.⁴

37
- 84971324235
- Formation of chromosomal domains by loop extrusion
- Fudenberg, G., M. Imakaev, C. Lu, A. Goloborodko, N. Abdennur, and L.A. Mirny. 2016. Formation of chromosomal domains by loop extrusion. Cell Reports. 15:2038-2049. http://dx.doi.org /10.1016 /j.celrep.2016.04.085
- (2016) Cell Reports , vol.15 , pp. 2038-2049
- Fudenberg, G.¹ Imakaev, M.² Lu, C.³ Goloborodko, A.⁴ Abdennur, N.⁵ Mirny, L.A.⁶

38
- 42149160535
- Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A
- Galiová, G., E. Bártová, I. Raska, J. Krejcí, and S. Kozubek. 2008. Chromatin changes induced by lamin A/C deficiency and the histone deacetylase inhibitor trichostatin A. Eur. J. Cell Biol. 87:291-303. http://dx.doi.org /10.1016 /j.ejcb.2008.01.013
- (2008) Eur. J. Cell Biol , vol.87 , pp. 291-303
- Galiová, G.¹ Bártová, E.² Raska, I.³ Krejcí, J.⁴ Kozubek, S.⁵

39
- 84902212007
- The 3D genome in transcriptional regulation and pluripotency
- Gorkin, D.U., D. Leung, and B. Ren. 2014. The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell. 14:762-775. http://dx.doi.org /10.1016 /j.stem.2014.05.017
- (2014) Cell Stem Cell , vol.14 , pp. 762-775
- Gorkin, D.U.¹ Leung, D.² Ren, B.³

40
- 45149084413
- Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
- Guelen, L., L. Pagie, E. Brasset, W. Meuleman, M.B. Faza, W. Talhout, B.H. Eussen, A. de Klein, L. Wessels, W. de Laat, and B. van Steensel. 2008. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature. 453:948-951. http://dx.doi.org /10.1038 /nature06947
- (2008) Nature , vol.453 , pp. 948-951
- Guelen, L.¹ Pagie, L.² Brasset, E.³ Meuleman, W.⁴ Faza, M.B.⁵ Talhout, W.⁶ Eussen, B.H.⁷ de Klein, A.⁸ Wessels, L.⁹ de Laat, W.¹⁰ van Steensel, B.¹¹

41
- 78650186593
- Cohesin organizes chromatin loops at DNA replication factories
- Guillou, E., A. Ibarra, V. Coulon, J. Casado-Vela, D. Rico, I. Casal, E. Schwob, A. Losada, and J. Méndez. 2010. Cohesin organizes chromatin loops at DNA replication factories. Genes Dev. 24:2812-2822. http://dx.doi.org /10.1101 /gad.608210
- (2010) Genes Dev , vol.24 , pp. 2812-2822
- Guillou, E.¹ Ibarra, A.² Coulon, V.³ Casado-Vela, J.⁴ Rico, D.⁵ Casal, I.⁶ Schwob, E.⁷ Losada, A.⁸ Méndez, J.⁹

42
- 84939246295
- CRI SPR inversion of CTCF sites alters genome topology and enhancer/promoter function
- Guo, Y., Q. Xu, D. Canzio, J. Shou, J. Li, D.U. Gorkin, I. Jung, H. Wu, Y. Zhai, Y. Tang, et al. 2015. CRI SPR inversion of CTCF sites alters genome topology and enhancer/promoter function. Cell. 162:900-910. http://dx.doi.org /10.1016 /j.cell.2015.07.038
- (2015) Cell , vol.162 , pp. 900-910
- Guo, Y.¹ Xu, Q.² Canzio, D.³ Shou, J.⁴ Li, J.⁵ Gorkin, D.U.⁶ Jung, I.⁷ Wu, H.⁸ Zhai, Y.⁹ Tang, Y.¹⁰

43
- 85018753870
- The cohesin release factor WAPL restricts chromatin loop extension
- Haarhuis, J.H.I., R.H. van der Weide, V.A. Blomen, J.O. Yanez-Cuna, M. Amendola, M.S. van Ruiten, P.H.L. Krijger, H. Teunissen, R.H. Medema, B. van Steensel, T.R. Brummelkamp, E. de Wit, and B.D. Rowland. 2017. The cohesin release factor WAPL restricts chromatin loop extension. Cell.169:693-707.e14. http://dx.doi.org /10.1016 /j.cell.2017.04.013
- (2017) Cell , vol.169
- Haarhuis, J.H.I.¹ van der Weide, R.H.² Blomen, V.A.³ Yanez-Cuna, J.O.⁴ Amendola, M.⁵ van Ruiten, M.S.⁶ Krijger, P.H.L.⁷ Teunissen, H.⁸ Medema, R.H.⁹ van Steensel, B.¹⁰ Brummelkamp, T.R.¹¹ de Wit, E.¹² Rowland, B.D.¹³

44
- 67650997080
- Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus
- Hadjur, S., L.M. Williams, N.K. Ryan, B.S. Cobb, T. Sexton, P. Fraser, A.G. Fisher, and M. Merkenschlager. 2009. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature. 460:410-413
- (2009) Nature , vol.460 , pp. 410-413
- Hadjur, S.¹ Williams, L.M.² Ryan, N.K.³ Cobb, B.S.⁴ Sexton, T.⁵ Fraser, P.⁶ Fisher, A.G.⁷ Merkenschlager, M.⁸

45
- 79959699992
- CTCF-mediated functional chromatin interactome in pluripotent cells
- Handoko, L., H. Xu, G. Li, C.Y. Ngan, E. Chew, M. Schnapp, C.W. Lee, C. Ye, J.L. Ping, F. Mulawadi, et al. 2011. CTCF-mediated functional chromatin interactome in pluripotent cells. Nat. Genet. 43:630-638. http://dx.doi.org /10.1038 /ng.857
- (2011) Nat. Genet , vol.43 , pp. 630-638
- Handoko, L.¹ Xu, H.² Li, G.³ Ngan, C.Y.⁴ Chew, E.⁵ Schnapp, M.⁶ Lee, C.W.⁷ Ye, C.⁸ Ping, J.L.⁹ Mulawadi, F.¹⁰

46
- 0034713275
- CTCF mediates methylation-sensitive enhancerblocking activity at the H19/Igf2 locus
- Hark, A.T., C.J. Schoenherr, D.J. Katz, R.S. Ingram, J.M. Levorse, and S.M. Tilghman. 2000. CTCF mediates methylation-sensitive enhancerblocking activity at the H19/Igf2 locus. Nature. 405:486-489. http://dx.doi.org /10.1038 /35013106
- (2000) Nature , vol.405 , pp. 486-489
- Hark, A.T.¹ Schoenherr, C.J.² Katz, D.J.³ Ingram, R.S.⁴ Levorse, J.M.⁵ Tilghman, S.M.⁶

47
- 84920871341
- Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
- Harr, J.C., T.R. Luperchio, X. Wong, E. Cohen, S.J. Wheelan, and K.L. Reddy. 2015. Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins. J. Cell Biol. 208:33-52. http://dx.doi.org /10.1083 /jcb.201405110
- (2015) J. Cell Biol , vol.208 , pp. 33-52
- Harr, J.C.¹ Luperchio, T.R.² Wong, X.³ Cohen, E.⁴ Wheelan, S.J.⁵ Reddy, K.L.⁶

48
- 67249117049
- Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
- Hindorff, L.A., P. Sethupathy, H.A. Junkins, E.M. Ramos, J.P. Mehta, F.S. Collins, and T.A. Manolio. 2009. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. USA. 106:9362-9367. http://dx.doi.org /10.1073 /pnas.0903103106
- (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9362-9367
- Hindorff, L.A.¹ Sethupathy, P.² Junkins, H.A.³ Ramos, E.M.⁴ Mehta, J.P.⁵ Collins, F.S.⁶ Manolio, T.A.⁷

49
- 84960171833
- Activation of proto-oncogenes by disruption of chromosome neighborhoods
- Hnisz, D., A.S. Weintraub, D.S. Day, A.-L. Valton, R.O. Bak, C.H. Li, J. Goldmann, B.R. Lajoie, Z.P. Fan, A.A. Sigova, et al. 2016. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 351:1454-1458. http://dx.doi.org /10.1126 /science.aad9024
- (2016) Science , vol.351 , pp. 1454-1458
- Hnisz, D.¹ Weintraub, A.S.² Day, D.S.³ Valton, A.-L.⁴ Bak, R.O.⁵ Li, C.H.⁶ Goldmann, J.⁷ Lajoie, B.R.⁸ Fan, Z.P.⁹ Sigova, A.A.¹⁰

50
- 84869003748
- Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains
- Hou, C., L. Li, Z.S. Qin, and V.G. Corces. 2012. Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol. Cell. 48:471-484. http://dx.doi.org /10.1016 /j.molcel.2012.08.031
- (2012) Mol. Cell , vol.48 , pp. 471-484
- Hou, C.¹ Li, L.² Qin, Z.S.³ Corces, V.G.⁴

51
- 84902096048
- Development and applications of CRI SPR-Cas9 for genome engineering
- Hsu, P.D., E.S. Lander, and F. Zhang. 2014. Development and applications of CRI SPR-Cas9 for genome engineering. Cell. 157:1262-1278. http://dx.doi.org /10.1016 /j.cell.2014.05.010
- (2014) Cell , vol.157 , pp. 1262-1278
- Hsu, P.D.¹ Lander, E.S.² Zhang, F.³

52
- 85003044117
- Deletions of chromosomal regulatory boundaries are associated with congenital disease
- Ibn-Salem, J., S. Köhler, M.I. Love, H.-R. Chung, N. Huang, M.E. Hurles, M. Haendel, N.L. Washington, D. Smedley, C.J. Mungall, et al. 2014. Deletions of chromosomal regulatory boundaries are associated with congenital disease. Genome Biol. 15:423. http://dx.doi.org /10.1186 / s13059-014-0423-1
- (2014) Genome Biol , vol.15 , pp. 423
- Ibn-Salem, J.¹ Köhler, S.² Love, M.I.³ Chung, H.-R.⁴ Huang, N.⁵ Hurles, M.E.⁶ Haendel, M.⁷ Washington, N.L.⁸ Smedley, D.⁹ Mungall, C.J.¹⁰

53
- 84923378921
- Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
- Jäger, R., G. Migliorini, M. Henrion, R. Kandaswamy, H.E. Speedy, A. Heindl, N. Whiffin, M.J. Carnicer, L. Broome, N. Dryden, et al. 2015. Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci. Nat. Commun. 6:6178. http://dx.doi.org /10.1038 /ncomms7178
- (2015) Nat. Commun , vol.6 , pp. 6178
- Jäger, R.¹ Migliorini, G.² Henrion, M.³ Kandaswamy, R.⁴ Speedy, H.E.⁵ Heindl, A.⁶ Whiffin, N.⁷ Carnicer, M.J.⁸ Broome, L.⁹ Dryden, N.¹⁰

54
- 84957850407
- 3D chromosome regulatory landscape of human resource 3D chromosome regulatory landscape of human pluripotent cells
- Ji, X., D.B. Dadon, B.E. Powell, T. Misteli, R. Jaenisch, R.A. Young, X. Ji, D.B. Dadon, B.E. Powell, Z.P. Fan, et al. 2016. 3D chromosome regulatory landscape of human resource 3D chromosome regulatory landscape of human pluripotent cells. Cell Stem Cell. 18:262-275. http:// dx.doi.org /10.1016 /j.stem.2015.11.007
- (2016) Cell Stem Cell , vol.18 , pp. 262-275
- Ji, X.¹ Dadon, D.B.² Powell, B.E.³ Misteli, T.⁴ Jaenisch, R.⁵ Young, R.A.⁶ Ji, X.⁷ Dadon, D.B.⁸ Powell, B.E.⁹ Fan, Z.P.¹⁰

55
- 77957139539
- Mediator and cohesin connect gene expression and chromatin architecture
- Kagey, M.H., J.J. Newman, S. Bilodeau, Y. Zhan, D.A. Orlando, N.L. van Berkum, C.C. Ebmeier, J. Goossens, P.B. Rahl, S.S. Levine, et al. 2010. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 467:430-435. http://dx.doi.org /10.1038 /nature09380
- (2010) Nature , vol.467 , pp. 430-435
- Kagey, M.H.¹ Newman, J.J.² Bilodeau, S.³ Zhan, Y.⁴ Orlando, D.A.⁵ van Berkum, N.L.⁶ Ebmeier, C.C.⁷ Goossens, J.⁸ Rahl, P.B.⁹ Levine, S.S.¹⁰

56
- 0034644120
- Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
- Kanduri, C., V. Pant, D. Loukinov, E. Pugacheva, C.F. Qi, A. Wolffe, R. Ohlsson, and V.V. Lobanenkov. 2000. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr. Biol. 10:853-856. http://dx.doi.org /10.1016 /S0960-9822(00)00597-2
- (2000) Curr. Biol , vol.10 , pp. 853-856
- Kanduri, C.¹ Pant, V.² Loukinov, D.³ Pugacheva, E.⁴ Qi, C.F.⁵ Wolffe, A.⁶ Ohlsson, R.⁷ Lobanenkov, V.V.⁸

57
- 84933278077
- CTCF/cohesinbinding sites are frequently mutated in cancer
- Katainen, R., K. Dave, E. Pitkänen, K. Palin, T. Kivioja, N. Välimäki, A.E. Gylfe, H. Ristolainen, U.A. Hänninen, T. Cajuso, et al. 2015. CTCF/cohesinbinding sites are frequently mutated in cancer. Nat. Genet. 47:818-821. http://dx.doi.org /10.1038 /ng.3335
- (2015) Nat. Genet , vol.47 , pp. 818-821
- Katainen, R.¹ Dave, K.² Pitkänen, E.³ Palin, K.⁴ Kivioja, T.⁵ Välimäki, N.⁶ Gylfe, A.E.⁷ Ristolainen, H.⁸ Hänninen, U.A.⁹ Cajuso, T.¹⁰

58
- 84901285464
- CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer
- Kemp, C.J., J.M. Moore, R. Moser, B. Bernard, M. Teater, L.E. Smith, N.A. Rabaia, K.E. Gurley, J. Guinney, S.E. Busch, et al. 2014. CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer. Cell Reports. 7:1020-1029. http://dx.doi.org /10.1016 /j.celrep.2014.04.004
- (2014) Cell Reports , vol.7 , pp. 1020-1029
- Kemp, C.J.¹ Moore, J.M.² Moser, R.³ Bernard, B.⁴ Teater, M.⁵ Smith, L.E.⁶ Rabaia, N.A.⁷ Gurley, K.E.⁸ Guinney, J.⁹ Busch, S.E.¹⁰

59
- 33947201809
- Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome
- Kim, T.H., Z.K. Abdullaev, A.D. Smith, K.A. Ching, D.I. Loukinov, R.D. Green, M.Q. Zhang, V.V. Lobanenkov, and B. Ren. 2007. Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell. 128:1231-1245. http://dx.doi.org /10.1016 /j.cell.2006.12.048
- (2007) Cell , vol.128 , pp. 1231-1245
- Kim, T.H.¹ Abdullaev, Z.K.² Smith, A.D.³ Ching, K.A.⁴ Loukinov, D.I.⁵ Green, R.D.⁶ Zhang, M.Q.⁷ Lobanenkov, V.V.⁸ Ren, B.⁹

60
- 80053502216
- Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes
- Klein, I.A., W. Resch, M. Jankovic, T. Oliveira, A. Yamane, H. Nakahashi, M. Di Virgilio, A. Bothmer, A. Nussenzweig, D.F. Robbiani, et al. 2011. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell. 147:95-106. http://dx.doi.org /10.1016 /j.cell.2011.07.048
- (2011) Cell , vol.147 , pp. 95-106
- Klein, I.A.¹ Resch, W.² Jankovic, M.³ Oliveira, T.⁴ Yamane, A.⁵ Nakahashi, H.⁶ Di Virgilio, M.⁷ Bothmer, A.⁸ Nussenzweig, A.⁹ Robbiani, D.F.¹⁰

61
- 33746063711
- CTCF binding at the H19 imprinting control region mediates maternally inherited higherorder chromatin conformation to restrict enhancer access to Igf2
- Kurukuti, S., V.K. Tiwari, G. Tavoosidana, E. Pugacheva, A. Murrell, Z. Zhao, V. Lobanenkov, W. Reik, and R. Ohlsson. 2006. CTCF binding at the H19 imprinting control region mediates maternally inherited higherorder chromatin conformation to restrict enhancer access to Igf2. Proc. Natl. Acad. Sci. USA. 103:10684-10689. http://dx.doi.org /10.1073 /pnas.0600326103
- (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10684-10689
- Kurukuti, S.¹ Tiwari, V.K.² Tavoosidana, G.³ Pugacheva, E.⁴ Murrell, A.⁵ Zhao, Z.⁶ Lobanenkov, V.⁷ Reik, W.⁸ Ohlsson, R.⁹

62
- 84862908850
- Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation
- Li, G., X. Ruan, R.K. Auerbach, K.S. Sandhu, M. Zheng, P. Wang, H.M. Poh, Y. Goh, J. Lim, J. Zhang, et al. 2012. Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell. 148:84-98. http://dx.doi.org /10.1016 /j.cell.2011.12.014
- (2012) Cell , vol.148 , pp. 84-98
- Li, G.¹ Ruan, X.² Auerbach, R.K.³ Sandhu, K.S.⁴ Zheng, M.⁵ Wang, P.⁶ Poh, H.M.⁷ Goh, Y.⁸ Lim, J.⁹ Zhang, J.¹⁰

63
- 70349873824
- Comprehensive mapping of long-range interactions reveals folding principles of the human genome
- Lieberman-Aiden, E., N.L. van Berkum, L. Williams, M. Imakaev, T. Ragoczy, A. Telling, I. Amit, B.R. Lajoie, P.J. Sabo, M.O. Dorschner, et al. 2009. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science. 326:289-293. http://dx.doi.org /10.1126 /science.1181369
- (2009) Science , vol.326 , pp. 289-293
- Lieberman-Aiden, E.¹ van Berkum, N.L.² Williams, L.³ Imakaev, M.⁴ Ragoczy, T.⁵ Telling, A.⁶ Amit, I.⁷ Lajoie, B.R.⁸ Sabo, P.J.⁹ Dorschner, M.O.¹⁰

64
- 52949104381
- Cohesin and human disease
- Liu, J., and I.D. Krantz. 2008. Cohesin and human disease. Annu. Rev. Genomics Hum. Genet. 9:303-320. http://dx.doi.org /10.1146 /annurev.genom.9.081307.164211
- (2008) Annu. Rev. Genomics Hum. Genet , vol.9 , pp. 303-320
- Liu, J.¹ Krantz, I.D.²

65
- 84930091577
- Disruptions of topological chromatin domains cause pathogenic rewiring of geneenhancer interactions
- Lupiáñez, D.G., K. Kraft, V. Heinrich, P. Krawitz, F. Brancati, E. Klopocki, D. Horn, H. Kayserili, J.M. Opitz, R. Laxova, et al. 2015. Disruptions of topological chromatin domains cause pathogenic rewiring of geneenhancer interactions. Cell. 161:1012-1025. http://dx.doi.org /10.1016 /j.cell.2015.04.004
- (2015) Cell , vol.161 , pp. 1012-1025
- Lupiáñez, D.G.¹ Kraft, K.² Heinrich, V.³ Krawitz, P.⁴ Brancati, F.⁵ Klopocki, E.⁶ Horn, D.⁷ Kayserili, H.⁸ Opitz, J.M.⁹ Laxova, R.¹⁰

66
- 84948686586
- Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
- Martin, P., A. McGovern, G. Orozco, K. Duffus, A. Yarwood, S. Schoenfelder, N.J. Cooper, A. Barton, C. Wallace, P. Fraser, et al. 2015. Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Nat. Commun. 6:10069. http://dx.doi.org /10.1038 /ncomms10069
- (2015) Nat. Commun , vol.6 , pp. 10069
- Martin, P.¹ McGovern, A.² Orozco, G.³ Duffus, K.⁴ Yarwood, A.⁵ Schoenfelder, S.⁶ Cooper, N.J.⁷ Barton, A.⁸ Wallace, C.⁹ Fraser, P.¹⁰

67
- 84955712613
- Chromatin states and nuclear organization in development-A view from the nuclear lamina
- Mattout, A., D.S. Cabianca, and S.M. Gasser. 2015. Chromatin states and nuclear organization in development-A view from the nuclear lamina. Genome Biol. 16:174. http://dx.doi.org /10.1186 /s13059-015-0747-5
- (2015) Genome Biol , vol.16 , pp. 174
- Mattout, A.¹ Cabianca, D.S.² Gasser, S.M.³

68
- 84865822182
- Systematic localization of common disease-associated variation in regulatory DNA
- Maurano, M.T., R. Humbert, E. Rynes, R.E. Thurman, E. Haugen, H. Wang, A.P. Reynolds, R. Sandstrom, H. Qu, J. Brody, et al. 2012. Systematic localization of common disease-associated variation in regulatory DNA. Science. 337:1190-1195. http://dx.doi.org /10.1126 /science.1222794
- (2012) Science , vol.337 , pp. 1190-1195
- Maurano, M.T.¹ Humbert, R.² Rynes, E.³ Thurman, R.E.⁴ Haugen, E.⁵ Wang, H.⁶ Reynolds, A.P.⁷ Sandstrom, R.⁸ Qu, H.⁹ Brody, J.¹⁰

69
- 84941021874
- Role of DNA methylation in modulating transcription factor occupancy
- Maurano, M.T., H. Wang, S. John, A. Shafer, T. Canfield, K. Lee, and J.A. Stamatoyannopoulos. 2015. Role of DNA methylation in modulating transcription factor occupancy. Cell Reports. 12:1184-1195. http://dx.doi.org /10.1016 /j.celrep.2015.07.024
- (2015) Cell Reports , vol.12 , pp. 1184-1195
- Maurano, M.T.¹ Wang, H.² John, S.³ Shafer, A.⁴ Canfield, T.⁵ Lee, K.⁶ Stamatoyannopoulos, J.A.⁷

70
- 0030885925
- Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
- Michaelis, C., R. Ciosk, and K. Nasmyth. 1997. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids. Cell. 91:35-45. http://dx.doi.org /10.1016 /S0092-8674(01)80007-6
- (1997) Cell , vol.91 , pp. 35-45
- Michaelis, C.¹ Ciosk, R.² Nasmyth, K.³

71
- 33847077659
- Beyond the sequence: cellular organization of genome function
- Misteli, T. 2007. Beyond the sequence: cellular organization of genome function. Cell. 128:787-800. http://dx.doi.org /10.1016 /j.cell.2007.01.028
- (2007) Cell , vol.128 , pp. 787-800
- Misteli, T.¹

72
- 62849083222
- The emerging role of nuclear architecture in DNA repair and genome maintenance
- Misteli, T., and E. Soutoglou. 2009. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat. Rev. Mol. Cell Biol. 10:243-254. http://dx.doi.org /10.1038 /nrm2651
- (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 243-254
- Misteli, T.¹ Soutoglou, E.²

73
- 84878590595
- A genome-wide map of CTCF multivalency redefines the CTCF code
- Nakahashi, H., K.R. Kieffer Kwon, W. Resch, L. Vian, M. Dose, D. Stavreva, O. Hakim, N. Pruett, S. Nelson, A. Yamane, et al. 2013. A genome-wide map of CTCF multivalency redefines the CTCF code. Cell Reports. 3:1678-1689. http://dx.doi.org /10.1016 /j.celrep.2013.04.024
- (2013) Cell Reports , vol.3 , pp. 1678-1689
- Nakahashi, H.¹ Kieffer Kwon, K.R.² Resch, W.³ Vian, L.⁴ Dose, M.⁵ Stavreva, D.⁶ Hakim, O.⁷ Pruett, N.⁸ Nelson, S.⁹ Yamane, A.¹⁰

74
- 0035678054
- Disseminating the genome: Joining, resolving, and separating sister chromatids during mitosis and meiosis
- Nasmyth, K. 2001. Disseminating the genome: Joining, resolving, and separating sister chromatids during mitosis and meiosis. Annu. Rev. Genet. 35:673-745. http://dx.doi.org /10.1146 /annurev.genet.35.102401.091334
- (2001) Annu. Rev. Genet , vol.35 , pp. 673-745
- Nasmyth, K.¹

75
- 80053495083
- Cohesin: A catenase with separate entry and exit gates?
- Nasmyth, K. 2011. Cohesin: A catenase with separate entry and exit gates? Nat. Cell Biol. 13:1170-1177. http://dx.doi.org /10.1038 /ncb2349
- (2011) Nat Cell Biol , vol.13 , pp. 1170-1177
- Nasmyth, K.¹

76
- 79953065005
- Genome organization in and around the nucleolus
- Németh, A., and G. Längst. 2011. Genome organization in and around the nucleolus. Trends Genet. 27:149-156. http://dx.doi.org /10.1016 /j.tig.2011.01.002
- (2011) Trends Genet , vol.27 , pp. 149-156
- Németh, A.¹ Längst, G.²

77
- 11144355499
- Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice
- Nikolova, V., C. Leimena, A.C. McMahon, J.C. Tan, S. Chandar, D. Jogia, S.H. Kesteven, J. Michalicek, R. Otway, F. Verheyen, et al. 2004. Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A/C-deficient mice. J. Clin. Invest. 113:357-369. http://dx.doi.org /10.1172 /JCI200419448
- (2004) J. Clin. Invest , vol.113 , pp. 357-369
- Nikolova, V.¹ Leimena, C.² McMahon, A.C.³ Tan, J.C.⁴ Chandar, S.⁵ Jogia, D.⁶ Kesteven, S.H.⁷ Michalicek, J.⁸ Otway, R.⁹ Verheyen, F.¹⁰

78
- 84861100147
- Spatial partitioning of the regulatory landscape of the X-inactivation centre
- Nora, E.P., B.R. Lajoie, E.G. Schulz, L. Giorgetti, I. Okamoto, N. Servant, T. Piolot, N.L. van Berkum, J. Meisig, J. Sedat, et al. 2012. Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature. 485:381-385. http://dx.doi.org /10.1038 /nature11049
- (2012) Nature , vol.485 , pp. 381-385
- Nora, E.P.¹ Lajoie, B.R.² Schulz, E.G.³ Giorgetti, L.⁴ Okamoto, I.⁵ Servant, N.⁶ Piolot, T.⁷ van Berkum, N.L.⁸ Meisig, J.⁹ Sedat, J.¹⁰

79
- 85019568830
- Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
- Nora, E.P., A. Goloborodko, A.L. Valton, J.H. Gibcus, A. Uebersohn, N. Abdennur, J. Dekker, L.A. Mirny, and B.G. Bruneau. 2017. Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization. Cell.169:930-944.e22. http://dx.doi.org /10.1016 /j.cell.2017.05.004
- (2017) Cell , vol.169
- Nora, E.P.¹ Goloborodko, A.² Valton, A.L.³ Gibcus, J.H.⁴ Uebersohn, A.⁵ Abdennur, N.⁶ Dekker, J.⁷ Mirny, L.A.⁸ Bruneau, B.G.⁹

80
- 0035451090
- CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease
- Ohlsson, R., R. Renkawitz, and V. Lobanenkov. 2001. CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet. 17:520-527. http://dx.doi.org /10.1016 /S0168-9525(01)02366-6
- (2001) Trends Genet , vol.17 , pp. 520-527
- Ohlsson, R.¹ Renkawitz, R.² Lobanenkov, V.³

81
- 84899415536
- CTCF: an architectural protein bridging genome topology and function
- Ong, C.-T., and V.G. Corces. 2014. CTCF: an architectural protein bridging genome topology and function. Nat. Rev. Genet. 15:234-246. http://dx.doi.org /10.1038 /nrg3663
- (2014) Nat. Rev. Genet , vol.15 , pp. 234-246
- Ong, C.-T.¹ Corces, V.G.²

82
- 4844223232
- Tissue-specific spatial organization of genomes
- Parada, L.A., P.G. McQueen, and T. Misteli. 2004. Tissue-specific spatial organization of genomes. Genome Biol. 5:R44. http://dx.doi.org /10.1186 /gb-2004-5-7-r44
- (2004) Genome Biol , vol.5 , pp. R44
- Parada, L.A.¹ McQueen, P.G.² Misteli, T.³

83
- 38849121606
- Cohesins functionally associate with CTCF on mammalian chromosome arms
- Parelho, V., S. Hadjur, M. Spivakov, M. Leleu, S. Sauer, H.C. Gregson, A. Jarmuz, C. Canzonetta, Z. Webster, T. Nesterova, et al. 2008. Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell. 132:422-433. http://dx.doi.org /10.1016 /j.cell.2008.01.011
- (2008) Cell , vol.132 , pp. 422-433
- Parelho, V.¹ Hadjur, S.² Spivakov, M.³ Leleu, M.⁴ Sauer, S.⁵ Gregson, H.C.⁶ Jarmuz, A.⁷ Canzonetta, C.⁸ Webster, Z.⁹ Nesterova, T.¹⁰

84
- 77952576224
- Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation
- Peric-Hupkes, D., W. Meuleman, L. Pagie, S.W. Bruggeman, I. Solovei, W. Brugman, S. Gräf, P. Flicek, R.M. Kerkhoven, M. van Lohuizen, et al. 2010. Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol. Cell. 38:603-613. http://dx.doi.org /10.1016 /j.molcel.2010.03.016
- (2010) Mol. Cell , vol.38 , pp. 603-613
- Peric-Hupkes, D.¹ Meuleman, W.² Pagie, L.³ Bruggeman, S.W.⁴ Solovei, I.⁵ Brugman, W.⁶ Gräf, S.⁷ Flicek, P.⁸ Kerkhoven, R.M.⁹ van Lohuizen, M.¹⁰

85
- 67549119096
- CTCF: Master weaver of the genome
- Phillips, J.E., and V.G. Corces. 2009. CTCF: Master weaver of the genome. Cell. 137:1194-1211. http://dx.doi.org /10.1016 /j.cell.2009.06.001
- (2009) Cell , vol.137 , pp. 1194-1211
- Phillips, J.E.¹ Corces, V.G.²

86
- 84878188440
- Chromatin insulators: Linking genome organization to cellular function
- Phillips-Cremins, J.E., and V.G. Corces. 2013. Chromatin insulators: Linking genome organization to cellular function. Mol. Cell. 50:461-474. http:// dx.doi.org /10.1016 /j.molcel.2013.04.018
- (2013) Mol. Cell , vol.50 , pp. 461-474
- Phillips-Cremins, J.E.¹ Corces, V.G.²

87
- 84878860751
- Architectural protein subclasses shape 3D organization of genomes during lineage commitment
- Phillips-Cremins, J.E., M.E. Sauria, A. Sanyal, T.I. Gerasimova, B.R. Lajoie, J.S. Bell, C.T. Ong, T.A. Hookway, C. Guo, Y. Sun, et al. 2013. Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell. 153:1281-1295. http://dx.doi.org /10.1016 /j.cell.2013.04.053
- (2013) Cell , vol.153 , pp. 1281-1295
- Phillips-Cremins, J.E.¹ Sauria, M.E.² Sanyal, A.³ Gerasimova, T.I.⁴ Lajoie, B.R.⁵ Bell, J.S.⁶ Ong, C.T.⁷ Hookway, T.A.⁸ Guo, C.⁹ Sun, Y.¹⁰

88
- 84911478490
- Topologically associating domains are stable units of replication-timing regulation
- Pope, B.D., T. Ryba, V. Dileep, F. Yue, W. Wu, O. Denas, D.L. Vera, Y. Wang, R.S. Hansen, T.K. Canfield, et al. 2014. Topologically associating domains are stable units of replication-timing regulation. Nature. 515:402-405. http://dx.doi.org /10.1038 /nature13986
- (2014) Nature , vol.515 , pp. 402-405
- Pope, B.D.¹ Ryba, T.² Dileep, V.³ Yue, F.⁴ Wu, W.⁵ Denas, O.⁶ Vera, D.L.⁷ Wang, Y.⁸ Hansen, R.S.⁹ Canfield, T.K.¹⁰

89
- 84919941546
- B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity
- Qian, J., Q. Wang, M. Dose, N. Pruett, K.-R. Kieffer-Kwon, W. Resch, G. Liang, Z. Tang, E. Mathé, C. Benner, et al. 2014. B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell. 159:1524-1537. http://dx.doi.org /10.1016 /j.cell.2014.11.013
- (2014) Cell , vol.159 , pp. 1524-1537
- Qian, J.¹ Wang, Q.² Dose, M.³ Pruett, N.⁴ Kieffer-Kwon, K.-R.⁵ Resch, W.⁶ Liang, G.⁷ Tang, Z.⁸ Mathé, E.⁹ Benner, C.¹⁰

90
- 0029134795
- Allelotyping of ductal carcinoma in situ of the breast: Deletion of loci on 8p, 13q, 16q, 17p and 17q
- Radford, D.M., K.L. Fair, N.J. Phillips, J.H. Ritter, T. Steinbrueck, M.S. Holt, and H. Donis-Keller. 1995. Allelotyping of ductal carcinoma in situ of the breast: Deletion of loci on 8p, 13q, 16q, 17p and 17q. Cancer Res. 55:3399-3405
- (1995) Cancer Res , vol.55 , pp. 3399-3405
- Radford, D.M.¹ Fair, K.L.² Phillips, N.J.³ Ritter, J.H.⁴ Steinbrueck, T.⁵ Holt, M.S.⁶ Donis-Keller, H.⁷

91
- 33646591281
- Chromosome 16 tumor-suppressor genes in breast cancer
- Rakha, E.A., A.R. Green, D.G. Powe, R. Roylance, and I.O. Ellis. 2006. Chromosome 16 tumor-suppressor genes in breast cancer. Genes Chromosomes Cancer. 45:527-535. http://dx.doi.org /10.1002 /gcc.20318
- (2006) Genes Chromosomes Cancer , vol.45 , pp. 527-535
- Rakha, E.A.¹ Green, A.R.² Powe, D.G.³ Roylance, R.⁴ Ellis, I.O.⁵

92
- 84919949716
- A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping
- Rao, S.S., M.H. Huntley, N.C. Durand, E.K. Stamenova, I.D. Bochkov, J.T. Robinson, A.L. Sanborn, I. Machol, A.D. Omer, E.S. Lander, and E.L. Aiden. 2014. A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell. 159:1665-1680. http://dx.doi.org /10.1016 /j.cell.2014.11.021
- (2014) Cell , vol.159 , pp. 1665-1680
- Rao, S.S.¹ Huntley, M.H.² Durand, N.C.³ Stamenova, E.K.⁴ Bochkov, I.D.⁵ Robinson, J.T.⁶ Sanborn, A.L.⁷ Machol, I.⁸ Omer, A.D.⁹ Lander, E.S.¹⁰ Aiden, E.L.¹¹

93
- 36348985646
- Critical DNA binding interactions of the insulator protein CTCF: A small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci
- Renda, M., I. Baglivo, B. Burgess-Beusse, S. Esposito, R. Fattorusso, G. Felsenfeld, and P.V. Pedone. 2007. Critical DNA binding interactions of the insulator protein CTCF: A small number of zinc fingers mediate strong binding, and a single finger-DNA interaction controls binding at imprinted loci. J. Biol. Chem. 282:33336-33345. http://dx.doi.org /10.1074 /jbc.M706213200
- (2007) J. Biol. Chem , vol.282 , pp. 33336-33345
- Renda, M.¹ Baglivo, I.² Burgess-Beusse, B.³ Esposito, S.⁴ Fattorusso, R.⁵ Felsenfeld, G.⁶ Pedone, P.V.⁷

94
- 83255164884
- Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution
- Rhee, H.S., and B.F. Pugh. 2011. Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell. 147:1408-1419. http://dx.doi.org /10.1016 /j.cell.2011.11.013
- (2011) Cell , vol.147 , pp. 1408-1419
- Rhee, H.S.¹ Pugh, B.F.²

95
- 0038054340
- Spatial proximity of translocation-prone gene loci in human lymphomas
- Roix, J.J., P.G. McQueen, P.J. Munson, L.A. Parada, and T. Misteli. 2003. Spatial proximity of translocation-prone gene loci in human lymphomas. Nat. Genet. 34:287-291. http://dx.doi.org /10.1038 /ng1177
- (2003) Nat. Genet , vol.34 , pp. 287-291
- Roix, J.J.¹ McQueen, P.G.² Munson, P.J.³ Parada, L.A.⁴ Misteli, T.⁵

96
- 84881255212
- Spatial dynamics of chromosome translocations in living cells
- Roukos, V., T.C. Voss, C.K. Schmidt, S. Lee, D. Wangsa, and T. Misteli. 2013. Spatial dynamics of chromosome translocations in living cells. Science. 341:660-664. http://dx.doi.org /10.1126 /science.1237150
- (2013) Science , vol.341 , pp. 660-664
- Roukos, V.¹ Voss, T.C.² Schmidt, C.K.³ Lee, S.⁴ Wangsa, D.⁵ Misteli, T.⁶

97
- 46149113242
- CTCF physically links cohesin to chromatin
- Rubio, E.D., D.J. Reiss, P.L. Welcsh, C.M. Disteche, G.N. Filippova, N.S. Baliga, R. Aebersold, J.A. Ranish, and A. Krumm. 2008. CTCF physically links cohesin to chromatin. Proc. Natl. Acad. Sci. USA. 105:8309-8314. http://dx.doi.org /10.1073 /pnas.0801273105
- (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 8309-8314
- Rubio, E.D.¹ Reiss, D.J.² Welcsh, P.L.³ Disteche, C.M.⁴ Filippova, G.N.⁵ Baliga, N.S.⁶ Aebersold, R.⁷ Ranish, J.A.⁸ Krumm, A.⁹

98
- 84940034154
- Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution
- Sahlén, P., I. Abdullayev, D. Ramsköld, L. Matskova, N. Rilakovic, B. Lötstedt, T.J. Albert, J. Lundeberg, and R. Sandberg. 2015. Genome-wide mapping of promoter-anchored interactions with close to single-enhancer resolution. Genome Biol. 16:156. http://dx.doi.org /10.1186 /s13059-015-0727-9
- (2015) Genome Biol , vol.16 , pp. 156
- Sahlén, P.¹ Abdullayev, I.² Ramsköld, D.³ Matskova, L.⁴ Rilakovic, N.⁵ Lötstedt, B.⁶ Albert, T.J.⁷ Lundeberg, J.⁸ Sandberg, R.⁹

99
- 84948403758
- Chromatin extrusion explains key features of loop and domain formation in wildtype and engineered genomes
- Sanborn, A.L., S.S. Rao, S.C. Huang, N.C. Durand, M.H. Huntley, A.I. Jewett, I.D. Bochkov, D. Chinnappan, A. Cutkosky, J. Li, et al. 2015. Chromatin extrusion explains key features of loop and domain formation in wildtype and engineered genomes. Proc. Natl. Acad. Sci. USA. 112:E6456-E6465. http://dx.doi.org /10.1073 /pnas.1518552112
- (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. E6456-E6465
- Sanborn, A.L.¹ Rao, S.S.² Huang, S.C.³ Durand, N.C.⁴ Huntley, M.H.⁵ Jewett, A.I.⁶ Bochkov, I.D.⁷ Chinnappan, D.⁸ Cutkosky, A.⁹ Li, J.¹⁰

100
- 84865800494
- The long-range interaction landscape of gene promoters
- Sanyal, A., B.R. Lajoie, G. Jain, and J. Dekker. 2012. The long-range interaction landscape of gene promoters. Nature. 489:109-113. http://dx.doi.org /10.1038 /nature11279
- (2012) Nature , vol.489 , pp. 109-113
- Sanyal, A.¹ Lajoie, B.R.² Jain, G.³ Dekker, J.⁴

101
- 84865777825
- Linking disease associations with regulatory information in the human genome
- Schaub, M.A., A.P. Boyle, A. Kundaje, S. Batzoglou, and M. Snyder. 2012. Linking disease associations with regulatory information in the human genome. Genome Res. 22:1748-1759. http://dx.doi.org /10.1101 /gr.136127.111
- (2012) Genome Res , vol.22 , pp. 1748-1759
- Schaub, M.A.¹ Boyle, A.P.² Kundaje, A.³ Batzoglou, S.⁴ Snyder, M.⁵

102
- 84863393570
- Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages
- Schmidt, D., P.C. Schwalie, M.D. Wilson, B. Ballester, A. Gonçalves, C. Kutter, G.D. Brown, A. Marshall, P. Flicek, and D.T. Odom. 2012. Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages. Cell. 148:335-348. http://dx.doi.org /10.1016 /j.cell.2011.11.058
- (2012) Cell , vol.148 , pp. 335-348
- Schmidt, D.¹ Schwalie, P.C.² Wilson, M.D.³ Ballester, B.⁴ Gonçalves, A.⁵ Kutter, C.⁶ Brown, G.D.⁷ Marshall, A.⁸ Flicek, P.⁹ Odom, D.T.¹⁰

103
- 34547625955
- Genome-wide association scan shows genetic variants in the FTO gene are associated with obesityrelated traits
- Scuteri, A., S. Sanna, W.-M. Chen, M. Uda, G. Albai, J. Strait, S. Najjar, R. Nagaraja, M. Orrú, G. Usala, et al. 2007. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesityrelated traits. PLoS Genet. 3:e115. http://dx.doi.org /10.1371 /journal.pgen.0030115
- (2007) PLoS Genet , vol.3
- Scuteri, A.¹ Sanna, S.² Chen, W.-M.³ Uda, M.⁴ Albai, G.⁵ Strait, J.⁶ Najjar, S.⁷ Nagaraja, R.⁸ Orrú, M.⁹ Usala, G.¹⁰

104
- 84890504911
- Cohesinbased chromatin interactions enable regulated gene expression within preexisting architectural compartments
- Seitan, V.C., A.J. Faure, Y. Zhan, R.P. McCord, B.R. Lajoie, E. Ing-Simmons, B. Lenhard, L. Giorgetti, E. Heard, A.G. Fisher, et al. 2013. Cohesinbased chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res. 23:2066-2077. http://dx.doi.org /10.1101 /gr.161620.113
- (2013) Genome Res , vol.23 , pp. 2066-2077
- Seitan, V.C.¹ Faure, A.J.² Zhan, Y.³ McCord, R.P.⁴ Lajoie, B.R.⁵ Ing-Simmons, E.⁶ Lenhard, B.⁷ Giorgetti, L.⁸ Heard, E.⁹ Fisher, A.G.¹⁰

105
- 84856747483
- Three-dimensional folding and functional organization principles of the Drosophila genome
- Sexton, T., E. Yaffe, E. Kenigsberg, F. Bantignies, B. Leblanc, M. Hoichman, H. Parrinello, A. Tanay, and G. Cavalli. 2012. Three-dimensional folding and functional organization principles of the Drosophila genome. Cell. 148:458-472. http://dx.doi.org /10.1016 /j.cell.2012.01.010
- (2012) Cell , vol.148 , pp. 458-472
- Sexton, T.¹ Yaffe, E.² Kenigsberg, E.³ Bantignies, F.⁴ Leblanc, B.⁵ Hoichman, M.⁶ Parrinello, H.⁷ Tanay, A.⁸ Cavalli, G.⁹

106
- 84897855294
- Obesity-associated variants within FTO form long-range functional connections with IRX3
- Smemo, S., J.J. Tena, K.-H. Kim, E.R. Gamazon, N.J. Sakabe, C. Gómez-Marín, I. Aneas, F.L. Credidio, D.R. Sobreira, N.F. Wasserman, et al. 2014. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 507:371-375. http://dx.doi.org /10.1038 /nature13138
- (2014) Nature , vol.507 , pp. 371-375
- Smemo, S.¹ Tena, J.J.² Kim, K.-H.³ Gamazon, E.R.⁴ Sakabe, N.J.⁵ Gómez-Marín, C.⁶ Aneas, I.⁷ Credidio, F.L.⁸ Sobreira, D.R.⁹ Wasserman, N.F.¹⁰

107
- 64249139170
- Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution
- Solovei, I., M. Kreysing, C. Lanctôt, S. Kösem, L. Peichl, T. Cremer, J. Guck, and B. Joffe. 2009. Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution. Cell. 137:356-368. http://dx.doi.org /10.1016 /j.cell.2009.01.052
- (2009) Cell , vol.137 , pp. 356-368
- Solovei, I.¹ Kreysing, M.² Lanctôt, C.³ Kösem, S.⁴ Peichl, L.⁵ Cremer, T.⁶ Guck, J.⁷ Joffe, B.⁸

108
- 84873302358
- LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation
- Solovei, I., A.S. Wang, K. Thanisch, C.S. Schmidt, S. Krebs, M. Zwerger, T.V. Cohen, D. Devys, R. Foisner, L. Peichl, et al. 2013. LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell. 152:584-598. http://dx.doi.org /10.1016 /j.cell.2013.01.009
- (2013) Cell , vol.152 , pp. 584-598
- Solovei, I.¹ Wang, A.S.² Thanisch, K.³ Schmidt, C.S.⁴ Krebs, S.⁵ Zwerger, M.⁶ Cohen, T.V.⁷ Devys, D.⁸ Foisner, R.⁹ Peichl, L.¹⁰

109
- 78649921825
- Functional analysis of CTCF during mammalian limb development
- Soshnikova, N., T. Montavon, M. Leleu, N. Galjart, and D. Duboule. 2010. Functional analysis of CTCF during mammalian limb development. Dev. Cell. 19:819-830. http://dx.doi.org /10.1016 /j.devcel.2010.11.009
- (2010) Dev. Cell , vol.19 , pp. 819-830
- Soshnikova, N.¹ Montavon, T.² Leleu, M.³ Galjart, N.⁴ Duboule, D.⁵

110
- 34447574977
- Positional stability of single doublestrand breaks in mammalian cells
- Soutoglou, E., J.F. Dorn, K. Sengupta, M. Jasin, A. Nussenzweig, T. Ried, G. Danuser, and T. Misteli. 2007. Positional stability of single doublestrand breaks in mammalian cells. Nat. Cell Biol. 9:675-682. http://dx.doi.org /10.1038 /ncb1591
- (2007) Nat. Cell Biol , vol.9 , pp. 675-682
- Soutoglou, E.¹ Dorn, J.F.² Sengupta, K.³ Jasin, M.⁴ Nussenzweig, A.⁵ Ried, T.⁶ Danuser, G.⁷ Misteli, T.⁸

111
- 84870310006
- Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation
- Splinter, E., E. de Wit, H.J.G. van de Werken, P. Klous, and W. de Laat. 2012. Determining long-range chromatin interactions for selected genomic sites using 4C-seq technology: From fixation to computation. Methods. 58:221-230. http://dx.doi.org /10.1016 /j.ymeth.2012.04.009
- (2012) Methods , vol.58 , pp. 221-230
- Splinter, E.¹ de Wit, E.² van de Werken, H.J.G.³ Klous, P.⁴ de Laat, W.⁵

112
- 0033615969
- Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
- Sullivan, T., D. Escalante-Alcalde, H. Bhatt, M. Anver, N. Bhat, K. Nagashima, C.L. Stewart, and B. Burke. 1999. Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J. Cell Biol. 147:913-920. http://dx.doi.org /10.1083 /jcb.147.5.913
- (1999) J. Cell Biol , vol.147 , pp. 913-920
- Sullivan, T.¹ Escalante-Alcalde, D.² Bhatt, H.³ Anver, M.⁴ Bhat, N.⁵ Nagashima, K.⁶ Stewart, C.L.⁷ Burke, B.⁸

113
- 84895522959
- Functional and topological characteristics of mammalian regulatory domains
- Symmons, O., V.V. Uslu, T. Tsujimura, S. Ruf, S. Nassari, W. Schwarzer, L. Ettwiller, and F. Spitz. 2014. Functional and topological characteristics of mammalian regulatory domains. Genome Res. 24:390-400. http://dx.doi.org /10.1101 /gr.163519.113
- (2014) Genome Res , vol.24 , pp. 390-400
- Symmons, O.¹ Uslu, V.V.² Tsujimura, T.³ Ruf, S.⁴ Nassari, S.⁵ Schwarzer, W.⁶ Ettwiller, L.⁷ Spitz, F.⁸

114
- 84923609539
- Nuclear envelope and genome interactions in cell fate
- Talamas, J.A., and M. Capelson. 2015. Nuclear envelope and genome interactions in cell fate. Front. Genet. 6:95. http://dx.doi.org /10.3389 /fgene.2015.00095
- (2015) Front. Genet , vol.6 , pp. 95
- Talamas, J.A.¹ Capelson, M.²

115
- 84951567954
- CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription
- Tang, Z., O.J. Luo, X. Li, M. Zheng, J.J. Zhu, P. Szalaj, P. Trzaskoma, A. Magalska, J. Wlodarczyk, B. Ruszczycki, et al. 2015. CTCF-mediated human 3D genome architecture reveals chromatin topology for transcription. Cell. 163:1611-1627. http://dx.doi.org /10.1016 /j.cell.2015.11.024
- (2015) Cell , vol.163 , pp. 1611-1627
- Tang, Z.¹ Luo, O.J.² Li, X.³ Zheng, M.⁴ Zhu, J.J.⁵ Szalaj, P.⁶ Trzaskoma, P.⁷ Magalska, A.⁸ Wlodarczyk, J.⁹ Ruszczycki, B.¹⁰

116
- 3142696838
- Lamin B1 is required for mouse development and nuclear integrity
- Vergnes, L., M. Péterfy, M.O. Bergo, S.G. Young, and K. Reue. 2004. Lamin B1 is required for mouse development and nuclear integrity. Proc. Natl. Acad. Sci. USA. 101:10428-10433. http://dx.doi.org /10.1073 /pnas.0401424101
- (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10428-10433
- Vergnes, L.¹ Péterfy, M.² Bergo, M.O.³ Young, S.G.⁴ Reue, K.⁵

117
- 84924533047
- Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture
- Vietri Rudan, M., C. Barrington, S. Henderson, C. Ernst, D.T. Odom, A. Tanay, and S. Hadjur. 2015. Comparative Hi-C reveals that CTCF underlies evolution of chromosomal domain architecture. Cell Reports. 10:1297-1309. http://dx.doi.org /10.1016 /j.celrep.2015.02.004
- (2015) Cell Reports , vol.10 , pp. 1297-1309
- Vietri Rudan, M.¹ Barrington, C.² Henderson, S.³ Ernst, C.⁴ Odom, D.T.⁵ Tanay, A.⁶ Hadjur, S.⁷

118
- 84875490185
- Cancer genome landscapes
- Vogelstein, B., N. Papadopoulos, V.E. Velculescu, S. Zhou, L.A. Diaz Jr., and K.W. Kinzler. 2013. Cancer genome landscapes. Science. 339:1546-1558. http://dx.doi.org /10.1126 /science.1235122
- (2013) Science , vol.339 , pp. 1546-1558
- Vogelstein, B.¹ Papadopoulos, N.² Velculescu, V.E.³ Zhou, S.⁴ Diaz, L.A.⁵ Kinzler, K.W.⁶

119
- 84865836579
- Widespread plasticity in CTCF occupancy linked to DNA methylation
- Wang, H., M.T. Maurano, H. Qu, K.E. Varley, J. Gertz, F. Pauli, K. Lee, T. Canfield, M. Weaver, R. Sandstrom, et al. 2012. Widespread plasticity in CTCF occupancy linked to DNA methylation. Genome Res. 22:1680-1688. http://dx.doi.org /10.1101 /gr.136101.111
- (2012) Genome Res , vol.22 , pp. 1680-1688
- Wang, H.¹ Maurano, M.T.² Qu, H.³ Varley, K.E.⁴ Gertz, J.⁵ Pauli, F.⁶ Lee, K.⁷ Canfield, T.⁸ Weaver, M.⁹ Sandstrom, R.¹⁰

120
- 59149083658
- Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
- Wen, B., H. Wu, Y. Shinkai, R.A. Irizarry, and A.P. Feinberg. 2009. Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat. Genet. 41:246-250. http://dx.doi.org /10.1038 /ng.297
- (2009) Nat. Genet , vol.41 , pp. 246-250
- Wen, B.¹ Wu, H.² Shinkai, Y.³ Irizarry, R.A.⁴ Feinberg, A.P.⁵

121
- 39149121436
- Cohesin mediates transcriptional insulation by CCC TC-binding factor
- Wendt, K.S., K. Yoshida, T. Itoh, M. Bando, B. Koch, E. Schirghuber, S. Tsutsumi, G. Nagae, K. Ishihara, T. Mishiro, et al. 2008. Cohesin mediates transcriptional insulation by CCC TC-binding factor. Nature. 451:796-801. http://dx.doi.org /10.1038 /nature06634
- (2008) Nature , vol.451 , pp. 796-801
- Wendt, K.S.¹ Yoshida, K.² Itoh, T.³ Bando, M.⁴ Koch, B.⁵ Schirghuber, E.⁶ Tsutsumi, S.⁷ Nagae, G.⁸ Ishihara, K.⁹ Mishiro, T.¹⁰

122
- 79151478493
- Genome organization influences partner selection for chromosomal rearrangements
- Wijchers, P.J., and W. de Laat. 2011. Genome organization influences partner selection for chromosomal rearrangements. Trends Genet. 27:63-71. http://dx.doi.org /10.1016 /j.tig.2010.11.001
- (2011) Trends Genet , vol.27 , pp. 63-71
- Wijchers, P.J.¹ de Laat, W.²

123
- 78650308767
- Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes
- Yamane, A., W. Resch, N. Kuo, S. Kuchen, Z. Li, H.-W. Sun, D.F. Robbiani, K. McBride, M.C. Nussenzweig, and R. Casellas. 2011. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat. Immunol. 12:62-69. http://dx.doi.org /10.1038 /ni.1964
- (2011) Nat. Immunol , vol.12 , pp. 62-69
- Yamane, A.¹ Resch, W.² Kuo, N.³ Kuchen, S.⁴ Li, Z.⁵ Sun, H.-W.⁶ Robbiani, D.F.⁷ McBride, K.⁸ Nussenzweig, M.C.⁹ Casellas, R.¹⁰

124
- 84938412430
- The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation
- Yang, F., X. Deng, W. Ma, J.B. Berletch, N. Rabaia, G. Wei, J.M. Moore, G.N. Filippova, J. Xu, Y. Liu, et al. 2015. The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation. Genome Biol. 16:52. http://dx.doi.org /10.1186 /s13059-015-0618-0
- (2015) Genome Biol , vol.16 , pp. 52
- Yang, F.¹ Deng, X.² Ma, W.³ Berletch, J.B.⁴ Rabaia, N.⁵ Wei, G.⁶ Moore, J.M.⁷ Filippova, G.N.⁸ Xu, J.⁹ Liu, Y.¹⁰

125
- 84862778059
- Spatial organization of the mouse genome and its role in recurrent chromosomal translocations
- Zhang, Y., R.P. McCord, Y.J. Ho, B.R. Lajoie, D.G. Hildebrand, A.C. Simon, M.S. Becker, F.W. Alt, and J. Dekker. 2012. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 148:908-921. http://dx.doi.org /10.1016 /j.cell.2012.02.002
- (2012) Cell , vol.148 , pp. 908-921
- Zhang, Y.¹ McCord, R.P.² Ho, Y.J.³ Lajoie, B.R.⁴ Hildebrand, D.G.⁵ Simon, A.C.⁶ Becker, M.S.⁷ Alt, F.W.⁸ Dekker, J.⁹

126
- 84892934183
- Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells
- Zuin, J., J.R. Dixon, M.I. van der Reijden, Z. Ye, P. Kolovos, R.W. Brouwer, M.P. van de Corput, H.J. van de Werken, T.A. Knoch, W.F. van IJcken, et al. 2014. Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells. Proc. Natl. Acad. Sci. USA. 111:996-1001. http://dx.doi.org /10.1073 /pnas.1317788111
- (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 996-1001
- Zuin, J.¹ Dixon, J.R.² van der Reijden, M.I.³ Ye, Z.⁴ Kolovos, P.⁵ Brouwer, R.W.⁶ van de Corput, M.P.⁷ van de Werken, H.J.⁸ Knoch, T.A.⁹ van IJcken, W.F.¹⁰

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.