Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter its DNA-binding specificity

Cancer Research

Volumn 62, Issue 1, 2002, Pages 48-52

  Filippova, Galina N ^a   Ulmer, Jonathan E ^a   Moore, James M ^a   Ward, Michael D ^a   Hu, Ying J ^a   Neiman, Paul E ^a   Collins, Steven J ^a   Qi, Chen Feng ^b   Loukinov, Dmitri I ^b   Pugacheva, Elena M ^b   Morse, Herbert C ^b   Lobanenkov, Victor V ^b   Klenova, Elena M ^c   Grundy, Paul E ^d   Feinberg, Andrew P ^e   Cleton Jansen, Anne Marie ^f   Moerland, Elna W ^f   Cornelisse, Cees J ^f   Suzuki, Hiroyoshi ^g   Komiya, Akira ^g   Lindblom, Annika ^h   Dorion Bonnet, Françoise ⁱ   more..

^a Fred Hutchinson Cancer Research Center   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF ESSEX   (United Kingdom)

^d CROSS CANCER INSTITUTE   (Canada)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f LEIDEN UNIVERSITY   (Netherlands)

^g CHIBA UNIVERSITY   (Japan)

^h KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

ⁱ INSTITUT BERGONIÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CTCF; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BREAST TUMOR; CANCER; CELL PROLIFERATION; GENE CONTROL; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; NEPHROBLASTOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE TUMOR; PROTEIN DNA BINDING; SCREENING TEST; SEQUENCE ANALYSIS; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; BASE SEQUENCE; BREAST NEOPLASMS; CELL CYCLE PROTEINS; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; GENES, TUMOR SUPPRESSOR; GLOBINS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MURAMIDASE; MUTATION, MISSENSE; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; PROTEIN CONFORMATION; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; WILMS TUMOR; ZINC FINGERS;

EID: 0036141521     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5′-flanking sequence of the chicken c-myc gene
2. CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms
3. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
4. The zinc finger protein CTCF binds to the APBβ domain of the amyloid β-protein precursor promoter. Evidence for a role in transcriptional activation
5. Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF
6. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
7. CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DMI locus
8. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
9. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
10. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive
11. Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence
12. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers
13. High-resolution integrated map encompassing the breast cancer loss of heterozygosity region on human chromosome 16q22.1
14. Comparative sensitivity of alternative single-strand conformation polymorphism (SSCP) methods
15. At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer
16. Deletions on chromosome 16 in primary familial breast carcinomas are associated with development of distant metastases
17. Three distinct commonly deleted regions of chromosome arm 16q in human primary and metastatic prostate cancers
18. A third Wilms’ tumor locus on chromosome 16q
19. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1
20. Characterization of the chicken CTCF genomic locus, and initial study of the cell cycle-regulated promoter of the gene
21. Physical basis of a protein-DNA recognition code
22. Genetic analysis of Xenopus transcription factor IIIA
23. Igf2 imprinting in development and disease
24. DNA methylation, genomic imprinting and cancer
25. LOI of IGF2 in Wilms’ tumors involves altered methylation but not mutations of CTCF or its binding site