Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive

Current Biology

Volumn 10, Issue 14, 2000, Pages 853-856

  Kanduri, Chandrasekhar ^a   Pant, Vinod ^a   Loukinov, Dmitri ^b   Pugacheva, Elena ^b   Qi, Chen Feng ^b   Wolffe, Alan ^c   Ohlsson, Rolf ^a   Lobanenkov, Victor V ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b Sect Clin and Exp Neuropsychol   (United States)

^c SANGAMO BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MAMMALIA;

EID: 0034644120     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00597-2     Document Type: Article

References (10)

1. Ohlsson R. Genomic imprinting, an interdisciplinary approach. Hennig W., Nover L., Scheer U. Results and Problems in Cell Differentiation, vol 25. 1999;Heidelberg, Springer, Berlin, New York.
2. Bartolomei M.S., Tilghman S.M. Genomic imprinting in mammals. Annu Rev Genet. 31:1997;493-525.
3. Leighton P., Saam J., Ingram R., Stewart C., Tilghman S. An enhancer deletion affects both H19 and Igf2 expression. Genes Dev. 9:1995;2079-2089.
4. Thorvaldsen J.L., Duran K.L., Bartolomei M.S. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev. 12:1998;3693-3702.
5. Kanduri C., Holmgren C., Pilartz M., Franklin G., Ullerås E., Kanduri M.et al. The 5′-flank of the murine H19 gene in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication. Curr Biol. 10:2000;449-457.
6. Olek A., Walter J. The pre-implantation ontogeny of the H19 methylation imprint. Nat Genet. 17:1997;275-276.
7. Tremblay K., Duran K., Bartolomei M.S. A 5′ 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol Cell Biol. 17:1997;4322-4329.
8. Filippova G.N., Lindblom A., Meincke L.J., Klenova E.M., Neiman P.E., Collins S.J.et al. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes Chromosomes Cancer. 22:1998;26-36.
9. Awad T.A., Bigler J., Ulmer J.E., Hu Y.J., Moore J.M., Lutz M.et al. Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence. J Biol Chem. 274:1999;27092-27098.
10. Bell A., West A., Felsenfeld G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell. 98:1999;387-396.