CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease

Trends in Genetics

Volumn 17, Issue 9, 2001, Pages 520-527

  Ohlsson, Rolf ^a   Renkawitz, Rainer ^b   Lobanenkov, Victor ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; PROTEIN CTCF; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO ACID SUBSTITUTION; CARCINOMA; CELL GROWTH; CHROMATIN; COMPLEX FORMATION; DISEASE ASSOCIATION; DNA PROTEIN COMPLEX; GENE ACTIVATION; GENE REPRESSION; GENE SILENCING; GENETIC VARIABILITY; HUMAN; METHYLATION; MISSENSE MUTATION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; DNA-BINDING PROTEINS; ENVIRONMENT; GENE EXPRESSION REGULATION; GENES, MYC; GENETICS, MEDICAL; HUMANS; NEOPLASMS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0035451090     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02366-6     Document Type: Review

References (65)

1. Chromatin proteins specifically interacting with certain DNA sequences
2. CCCTC-binding protein: A new nuclear protein factor which interaction with 5′-flanking sequence of chicken c-myc oncogene correlates with repression of the gene
3. CCCTC-binding factor (CTCF): A novel sequence-specific DNA-binding protein which interacts with the 5′-flanking sequence of the chicken c-myc gene
4. A novel sequence-specific DNA-binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5′- flanking sequence of the chicken c-myc gene
5. CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms
6. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes
7. Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF
8. Modular structure of a chicken lysozyme silencer: Involvement of an unusual thyroid hormone receptor binding site
9. NeP1. A ubiquitous transcription factor synergizes with v-ERBA in transcriptional silencing
10. Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF
11. The initiator element and proximal upstream sequences affect transcriptional activity and start site selection in the amyloid beta-protein precursor promoter
12. The chicken β-globin 5′HS4 boundary element blocks enhancer-mediated suppression of silencing
13. The zinc finger protein CTCF binds to the APBbeta domain of the amyloid beta-protein precursor promoter. Evidence for a role in transcriptional activation
14. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
15. Characterization of the chicken CTCF genomic locus, and initial study of the cell cycle-regulated promoter of the gene
16. Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene
17. Transcriptional Repression by the insulator protein CTCF involves histone deacetylases
18. Zinc finger proteins: What we know and what we would like to know
19. Protein motifs. Zinc fingers
20. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers
21. Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence
22. Functional association of CTCF with the insulator upstream of the H19 gene is a parent of origin-specific and methylation-sensitive
23. Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene
24. DNA recognition by Cys2His2 zinc finger proteins
25. Geometric analysis and comparison of protein-DNA interfaces: Why is there no simple code for recognition?
26. Physical basis of a protein-DNA recognition code
27. Differing roles for zinc fingers in DNA recognition: Structure of a six- finger transcription factor IIIA complex
28. Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF
29. Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: Two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core
30. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways
31. AT-hook motifs identified in a wide variety of DNA-binding proteins
32. Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y)
33. Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains
34. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase
35. Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53
36. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1
37. Cloning and characterization of proteins that bind to the C-terminal domain of p53
38. Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2
39. BIN1 is a novel MYC-interacting protein with features of a tumour suppressor
40. CTCF is essential for up-regulating expression from the amyloid precursor protein promoter during differentiation of primary hippocampal neurons
41. Modulation of thyroid hormone receptor silencing function by co-repressors and a synergizing transcription factor
42. An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells
43. DNA bending by the silencer protein NeP1 is modulated by TR and RXR
44. The insulator protein CTCF represses transcription on binding to the (gt)(22)(ga)(15) microsatellite in intron 2 of the HLA-DRB1(*)0401 gene
45. Insulators and boundaries: Versatile regulatory elements in the eukaryotic genome
46. Structural and functional conservation at the boundaries of the chicken beta-globin domain
47. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2
48. The 5′-flank of the murine H19 gene in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication
49. Genomic imprinting in mammals
50. An enhancer deletion affects both H19 and Igf2 expression
51. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
52. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
53. Looping versus linking: Toward a model for long-distance gene activation
54. Deletion of a silencer element in lgf2 results in loss of imprinting independent of H19
55. A chromatin insulator determines the nuclear localization of DNA
56. The mechanisms of genomic imprinting
57. CpG methylation regulates the Igf2/H19 insulator
58. A 5 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development
59. Cancer epigenetics takes center stage
60. Pausing for thought on the boundaries of imprinting
61. Genomic imprinting and cancer
62. Imprinting in development and disease
63. Co-repressors 2000
64. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers
65. Cell growth inhibition by the multivalent multifunctional transcriptional factor CTCF