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Volumn 8, Issue , 2017, Pages 494-507

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease

Author keywords

cardiovascular development; cardiovascular disease; cardiovascular system; long non coding RNAs; non coding RNAs; RNAs; therapy; transcriptomics; vascular disease

Indexed keywords

LONG UNTRANSLATED RNA;

EID: 85029328956     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1016/j.omtn.2017.07.014     Document Type: Review
Times cited : (95)

References (178)
  • 1
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: advances, challenges and opportunities
    • Ozsolak, F., Milos, P.M., RNA sequencing: advances, challenges and opportunities. Nat. Rev. Genet. 12 (2011), 87–98.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 3
    • 84995467228 scopus 로고    scopus 로고
    • Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy
    • Bär, C., Chatterjee, S., Thum, T., Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy. Circulation 134 (2016), 1484–1499.
    • (2016) Circulation , vol.134 , pp. 1484-1499
    • Bär, C.1    Chatterjee, S.2    Thum, T.3
  • 4
    • 84995812347 scopus 로고    scopus 로고
    • Transcriptome of blood cells as a reservoir of cardiovascular biomarkers
    • Devaux, Y., Transcriptome of blood cells as a reservoir of cardiovascular biomarkers. Biochim. Biophys. Acta 1864 (2017), 209–216.
    • (2017) Biochim. Biophys. Acta , vol.1864 , pp. 209-216
    • Devaux, Y.1
  • 5
    • 84961221422 scopus 로고    scopus 로고
    • Long noncoding RNAs: From clinical genetics to therapeutic targets?
    • Boon, R.A., Jaé, N., Holdt, L., Dimmeler, S., Long noncoding RNAs: From clinical genetics to therapeutic targets?. J. Am. Coll. Cardiol. 67 (2016), 1214–1226.
    • (2016) J. Am. Coll. Cardiol. , vol.67 , pp. 1214-1226
    • Boon, R.A.1    Jaé, N.2    Holdt, L.3    Dimmeler, S.4
  • 6
    • 84890852686 scopus 로고    scopus 로고
    • Evolutionary conservation of long non-coding RNAs; sequence, structure, function
    • Johnsson, P., Lipovich, L., Grandér, D., Morris, K.V., Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochim. Biophys. Acta 1840 (2014), 1063–1071.
    • (2014) Biochim. Biophys. Acta , vol.1840 , pp. 1063-1071
    • Johnsson, P.1    Lipovich, L.2    Grandér, D.3    Morris, K.V.4
  • 8
    • 84899486799 scopus 로고    scopus 로고
    • The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation
    • Wang, P., Xue, Y., Han, Y., Lin, L., Wu, C., Xu, S., Jiang, Z., Xu, J., Liu, Q., Cao, X., The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation. Science 344 (2014), 310–313.
    • (2014) Science , vol.344 , pp. 310-313
    • Wang, P.1    Xue, Y.2    Han, Y.3    Lin, L.4    Wu, C.5    Xu, S.6    Jiang, Z.7    Xu, J.8    Liu, Q.9    Cao, X.10
  • 9
    • 80053045739 scopus 로고    scopus 로고
    • Molecular mechanisms of long noncoding RNAs
    • Wang, K.C., Chang, H.Y., Molecular mechanisms of long noncoding RNAs. Mol. Cell 43 (2011), 904–914.
    • (2011) Mol. Cell , vol.43 , pp. 904-914
    • Wang, K.C.1    Chang, H.Y.2
  • 12
    • 84949952099 scopus 로고    scopus 로고
    • Unique features of long non-coding RNA biogenesis and function
    • Quinn, J.J., Chang, H.Y., Unique features of long non-coding RNA biogenesis and function. Nat. Rev. Genet. 17 (2016), 47–62.
    • (2016) Nat. Rev. Genet. , vol.17 , pp. 47-62
    • Quinn, J.J.1    Chang, H.Y.2
  • 13
    • 84903817064 scopus 로고    scopus 로고
    • The ways of action of long non-coding RNAs in cytoplasm and nucleus
    • Zhang, K., Shi, Z.M., Chang, Y.N., Hu, Z.M., Qi, H.X., Hong, W., The ways of action of long non-coding RNAs in cytoplasm and nucleus. Gene 547 (2014), 1–9.
    • (2014) Gene , vol.547 , pp. 1-9
    • Zhang, K.1    Shi, Z.M.2    Chang, Y.N.3    Hu, Z.M.4    Qi, H.X.5    Hong, W.6
  • 16
    • 84925227935 scopus 로고    scopus 로고
    • Towards a therapy for Angelman syndrome by targeting a long non-coding RNA
    • Meng, L., Ward, A.J., Chun, S., Bennett, C.F., Beaudet, A.L., Rigo, F., Towards a therapy for Angelman syndrome by targeting a long non-coding RNA. Nature 518 (2015), 409–412.
    • (2015) Nature , vol.518 , pp. 409-412
    • Meng, L.1    Ward, A.J.2    Chun, S.3    Bennett, C.F.4    Beaudet, A.L.5    Rigo, F.6
  • 18
    • 84868383682 scopus 로고    scopus 로고
    • Targeting LDL cholesterol with LNA
    • Krieg, A.M., Targeting LDL cholesterol with LNA. Mol. Ther. Nucleic Acids, 1, 2012, e6.
    • (2012) Mol. Ther. Nucleic Acids , vol.1 , pp. e6
    • Krieg, A.M.1
  • 23
    • 84901434257 scopus 로고    scopus 로고
    • The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo
    • Werber, M., Wittler, L., Timmermann, B., Grote, P., Herrmann, B.G., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development 141 (2014), 2325–2330.
    • (2014) Development , vol.141 , pp. 2325-2330
    • Werber, M.1    Wittler, L.2    Timmermann, B.3    Grote, P.4    Herrmann, B.G.5
  • 24
    • 84993661633 scopus 로고    scopus 로고
    • A G-rich motif in the lncRNA Braveheart interacts with a zinc-finger transcription factor to specify the cardiovascular lineage
    • Xue, Z., Hennelly, S., Doyle, B., Gulati, A.A., Novikova, I.V., Sanbonmatsu, K.Y., Boyer, L.A., A G-rich motif in the lncRNA Braveheart interacts with a zinc-finger transcription factor to specify the cardiovascular lineage. Mol. Cell 64 (2016), 37–50.
    • (2016) Mol. Cell , vol.64 , pp. 37-50
    • Xue, Z.1    Hennelly, S.2    Doyle, B.3    Gulati, A.A.4    Novikova, I.V.5    Sanbonmatsu, K.Y.6    Boyer, L.A.7
  • 29
    • 84995752852 scopus 로고    scopus 로고
    • Microarray analysis reveals a potential role of lncRNAs expression in cardiac cell proliferation
    • Wang, J., Geng, Z., Weng, J., Shen, L., Li, M., Cai, X., Sun, C., Chu, M., Microarray analysis reveals a potential role of lncRNAs expression in cardiac cell proliferation. BMC Dev. Biol., 16, 2016, 41.
    • (2016) BMC Dev. Biol. , vol.16 , pp. 41
    • Wang, J.1    Geng, Z.2    Weng, J.3    Shen, L.4    Li, M.5    Cai, X.6    Sun, C.7    Chu, M.8
  • 30
    • 84866927722 scopus 로고    scopus 로고
    • The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart
    • Korostowski, L., Sedlak, N., Engel, N., The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart. PLoS Genet., 8, 2012, e1002956.
    • (2012) PLoS Genet. , vol.8 , pp. e1002956
    • Korostowski, L.1    Sedlak, N.2    Engel, N.3
  • 31
    • 84910147922 scopus 로고    scopus 로고
    • Long noncoding RNAs in patients with acute myocardial infarction
    • Vausort, M., Wagner, D.R., Devaux, Y., Long noncoding RNAs in patients with acute myocardial infarction. Circ. Res. 115 (2014), 668–677.
    • (2014) Circ. Res. , vol.115 , pp. 668-677
    • Vausort, M.1    Wagner, D.R.2    Devaux, Y.3
  • 32
    • 0028983138 scopus 로고
    • Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro
    • VanBuren, P., Harris, D.E., Alpert, N.R., Warshaw, D.M., Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro. Circ. Res. 77 (1995), 439–444.
    • (1995) Circ. Res. , vol.77 , pp. 439-444
    • VanBuren, P.1    Harris, D.E.2    Alpert, N.R.3    Warshaw, D.M.4
  • 33
    • 0141733258 scopus 로고    scopus 로고
    • Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching
    • Haddad, F., Bodell, P.W., Qin, A.X., Giger, J.M., Baldwin, K.M., Role of antisense RNA in coordinating cardiac myosin heavy chain gene switching. J. Biol. Chem. 278 (2003), 37132–37138.
    • (2003) J. Biol. Chem. , vol.278 , pp. 37132-37138
    • Haddad, F.1    Bodell, P.W.2    Qin, A.X.3    Giger, J.M.4    Baldwin, K.M.5
  • 41
    • 77956927823 scopus 로고    scopus 로고
    • The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
    • Tripathi, V., Ellis, J.D., Shen, Z., Song, D.Y., Pan, Q., Watt, A.T., Freier, S.M., Bennett, C.F., Sharma, A., Bubulya, P.A., et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol. Cell 39 (2010), 925–938.
    • (2010) Mol. Cell , vol.39 , pp. 925-938
    • Tripathi, V.1    Ellis, J.D.2    Shen, Z.3    Song, D.Y.4    Pan, Q.5    Watt, A.T.6    Freier, S.M.7    Bennett, C.F.8    Sharma, A.9    Bubulya, P.A.10
  • 43
    • 84940831705 scopus 로고    scopus 로고
    • Down-regulation of SENCR promotes smooth muscle cells proliferation and migration in db/db mice through up-regulation of FoxO1 and TRPC6
    • Zou, Z.Q., Xu, J., Li, L., Han, Y.S., Down-regulation of SENCR promotes smooth muscle cells proliferation and migration in db/db mice through up-regulation of FoxO1 and TRPC6. Biomed. Pharmacother. 74 (2015), 35–41.
    • (2015) Biomed. Pharmacother. , vol.74 , pp. 35-41
    • Zou, Z.Q.1    Xu, J.2    Li, L.3    Han, Y.S.4
  • 44
    • 84863860758 scopus 로고    scopus 로고
    • Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesis
    • Ratajczak, M.Z., Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesis. Folia Histochem. Cytobiol. 50 (2012), 171–179.
    • (2012) Folia Histochem. Cytobiol. , vol.50 , pp. 171-179
    • Ratajczak, M.Z.1
  • 45
    • 21844477565 scopus 로고    scopus 로고
    • Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
    • Devlin, A.M., Bottiglieri, T., Domann, F.E., Lentz, S.R., Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia. J. Biol. Chem. 280 (2005), 25506–25511.
    • (2005) J. Biol. Chem. , vol.280 , pp. 25506-25511
    • Devlin, A.M.1    Bottiglieri, T.2    Domann, F.E.3    Lentz, S.R.4
  • 46
    • 84860599353 scopus 로고    scopus 로고
    • Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia
    • Ding, G.-L., Wang, F.-F., Shu, J., Tian, S., Jiang, Y., Zhang, D., Wang, N., Luo, Q., Zhang, Y., Jin, F., et al. Transgenerational glucose intolerance with Igf2/H19 epigenetic alterations in mouse islet induced by intrauterine hyperglycemia. Diabetes 61 (2012), 1133–1142.
    • (2012) Diabetes , vol.61 , pp. 1133-1142
    • Ding, G.-L.1    Wang, F.-F.2    Shu, J.3    Tian, S.4    Jiang, Y.5    Zhang, D.6    Wang, N.7    Luo, Q.8    Zhang, Y.9    Jin, F.10
  • 47
    • 84920998638 scopus 로고    scopus 로고
    • Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population
    • Gao, W., Zhu, M., Wang, H., Zhao, S., Zhao, D., Yang, Y., Wang, Z.M., Wang, F., Yang, Z.J., Lu, X., Wang, L.S., Association of polymorphisms in long non-coding RNA H19 with coronary artery disease risk in a Chinese population. Mutat. Res. 772 (2015), 15–22.
    • (2015) Mutat. Res. , vol.772 , pp. 15-22
    • Gao, W.1    Zhu, M.2    Wang, H.3    Zhao, S.4    Zhao, D.5    Yang, Y.6    Wang, Z.M.7    Wang, F.8    Yang, Z.J.9    Lu, X.10    Wang, L.S.11
  • 49
    • 0029866163 scopus 로고    scopus 로고
    • H19, a marker of developmental transition, is reexpressed in human atherosclerotic plaques and is regulated by the insulin family of growth factors in cultured rabbit smooth muscle cells
    • Han, D.K., Khaing, Z.Z., Pollock, R.A., Haudenschild, C.C., Liau, G., H19, a marker of developmental transition, is reexpressed in human atherosclerotic plaques and is regulated by the insulin family of growth factors in cultured rabbit smooth muscle cells. J. Clin. Invest. 97 (1996), 1276–1285.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1276-1285
    • Han, D.K.1    Khaing, Z.Z.2    Pollock, R.A.3    Haudenschild, C.C.4    Liau, G.5
  • 50
    • 0028057278 scopus 로고
    • H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury
    • Kim, D.K., Zhang, L., Dzau, V.J., Pratt, R.E., H19, a developmentally regulated gene, is reexpressed in rat vascular smooth muscle cells after injury. J. Clin. Invest. 93 (1994), 355–360.
    • (1994) J. Clin. Invest. , vol.93 , pp. 355-360
    • Kim, D.K.1    Zhang, L.2    Dzau, V.J.3    Pratt, R.E.4
  • 51
    • 68549125476 scopus 로고    scopus 로고
    • Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes
    • Li, L., Xie, J., Zhang, M., Wang, S., Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes. Acta Biochim. Biophys. Sin. (Shanghai) 41 (2009), 464–471.
    • (2009) Acta Biochim. Biophys. Sin. (Shanghai) , vol.41 , pp. 464-471
    • Li, L.1    Xie, J.2    Zhang, M.3    Wang, S.4
  • 52
    • 85007072223 scopus 로고    scopus 로고
    • The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy
    • Liu, L., An, X., Li, Z., Song, Y., Li, L., Zuo, S., Liu, N., Yang, G., Wang, H., Cheng, X., et al. The H19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy. Cardiovasc. Res. 111 (2016), 56–65.
    • (2016) Cardiovasc. Res. , vol.111 , pp. 56-65
    • Liu, L.1    An, X.2    Li, Z.3    Song, Y.4    Li, L.5    Zuo, S.6    Liu, N.7    Yang, G.8    Wang, H.9    Cheng, X.10
  • 53
    • 51549107100 scopus 로고    scopus 로고
    • Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice
    • Shao, W.-J., Tao, L.-Y., Gao, C., Xie, J.-Y., Zhao, R.-Q., Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice. Comp. Med. 58 (2008), 341–346.
    • (2008) Comp. Med. , vol.58 , pp. 341-346
    • Shao, W.-J.1    Tao, L.-Y.2    Gao, C.3    Xie, J.-Y.4    Zhao, R.-Q.5
  • 56
    • 0037408121 scopus 로고    scopus 로고
    • Imprinted mesodermal specific transcript (MEST) and H19 genes in renal development and diabetes
    • Kanwar, Y.S., Pan, X., Lin, S., Kumar, A., Wada, J., Haas, C.S., Liau, G., Lomasney, J.W., Imprinted mesodermal specific transcript (MEST) and H19 genes in renal development and diabetes. Kidney Int. 63 (2003), 1658–1670.
    • (2003) Kidney Int. , vol.63 , pp. 1658-1670
    • Kanwar, Y.S.1    Pan, X.2    Lin, S.3    Kumar, A.4    Wada, J.5    Haas, C.S.6    Liau, G.7    Lomasney, J.W.8
  • 57
    • 65049089188 scopus 로고    scopus 로고
    • The H19 gene imprinting in normal pregnancy and pre-eclampsia
    • Yu, L., Chen, M., Zhao, D., Yi, P., Lu, L., Han, J., Zheng, X., Zhou, Y., Li, L., The H19 gene imprinting in normal pregnancy and pre-eclampsia. Placenta 30 (2009), 443–447.
    • (2009) Placenta , vol.30 , pp. 443-447
    • Yu, L.1    Chen, M.2    Zhao, D.3    Yi, P.4    Lu, L.5    Han, J.6    Zheng, X.7    Zhou, Y.8    Li, L.9
  • 60
    • 84863157042 scopus 로고    scopus 로고
    • Negative feedback regulation between microRNA let-7g and the oxLDL receptor LOX-1
    • Chen, K.-C., Hsieh, I.C., Hsi, E., Wang, Y.-S., Dai, C.-Y., Chou, W.-W., Juo, S.H., Negative feedback regulation between microRNA let-7g and the oxLDL receptor LOX-1. J. Cell Sci. 124 (2011), 4115–4124.
    • (2011) J. Cell Sci. , vol.124 , pp. 4115-4124
    • Chen, K.-C.1    Hsieh, I.C.2    Hsi, E.3    Wang, Y.-S.4    Dai, C.-Y.5    Chou, W.-W.6    Juo, S.H.7
  • 61
    • 84858798596 scopus 로고    scopus 로고
    • Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and Toll-like receptor 4 signal
    • Satoh, M., Tabuchi, T., Minami, Y., Takahashi, Y., Itoh, T., Nakamura, M., Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and Toll-like receptor 4 signal. Immunobiology 217 (2012), 533–539.
    • (2012) Immunobiology , vol.217 , pp. 533-539
    • Satoh, M.1    Tabuchi, T.2    Minami, Y.3    Takahashi, Y.4    Itoh, T.5    Nakamura, M.6
  • 62
    • 84885292826 scopus 로고    scopus 로고
    • Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g
    • Ding, Z., Wang, X., Schnackenberg, L., Khaidakov, M., Liu, S., Singla, S., Dai, Y., Mehta, J.L., Regulation of autophagy and apoptosis in response to ox-LDL in vascular smooth muscle cells, and the modulatory effects of the microRNA hsa-let-7 g. Int. J. Cardiol. 168 (2013), 1378–1385.
    • (2013) Int. J. Cardiol. , vol.168 , pp. 1378-1385
    • Ding, Z.1    Wang, X.2    Schnackenberg, L.3    Khaidakov, M.4    Liu, S.5    Singla, S.6    Dai, Y.7    Mehta, J.L.8
  • 63
    • 84907450617 scopus 로고    scopus 로고
    • Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries
    • Bao, M.H., Zhang, Y.W., Lou, X.Y., Cheng, Y., Zhou, H.H., Protective effects of let-7a and let-7b on oxidized low-density lipoprotein induced endothelial cell injuries. PLoS ONE, 9, 2014, e106540.
    • (2014) PLoS ONE , vol.9 , pp. e106540
    • Bao, M.H.1    Zhang, Y.W.2    Lou, X.Y.3    Cheng, Y.4    Zhou, H.H.5
  • 64
    • 84866624519 scopus 로고    scopus 로고
    • MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis
    • Qin, B., Xiao, B., Liang, D., Li, Y., Jiang, T., Yang, H., MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis. BMB Rep. 45 (2012), 464–469.
    • (2012) BMB Rep. , vol.45 , pp. 464-469
    • Qin, B.1    Xiao, B.2    Liang, D.3    Li, Y.4    Jiang, T.5    Yang, H.6
  • 67
    • 84974806826 scopus 로고    scopus 로고
    • Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis
    • Tao, H., Cao, W., Yang, J.J., Shi, K.H., Zhou, X., Liu, L.P., Li, J., Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Cardiovasc. Pathol. 25 (2016), 381–389.
    • (2016) Cardiovasc. Pathol. , vol.25 , pp. 381-389
    • Tao, H.1    Cao, W.2    Yang, J.J.3    Shi, K.H.4    Zhou, X.5    Liu, L.P.6    Li, J.7
  • 70
  • 71
    • 61949252089 scopus 로고    scopus 로고
    • A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia
    • Liu, X., Cheng, Y., Zhang, S., Lin, Y., Yang, J., Zhang, C., A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ. Res. 104 (2009), 476–487.
    • (2009) Circ. Res. , vol.104 , pp. 476-487
    • Liu, X.1    Cheng, Y.2    Zhang, S.3    Lin, Y.4    Yang, J.5    Zhang, C.6
  • 72
    • 79953057954 scopus 로고    scopus 로고
    • Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration
    • Zhu, N., Zhang, D., Chen, S., Liu, X., Lin, L., Huang, X., Guo, Z., Liu, J., Wang, Y., Yuan, W., Qin, Y., Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration. Atherosclerosis 215 (2011), 286–293.
    • (2011) Atherosclerosis , vol.215 , pp. 286-293
    • Zhu, N.1    Zhang, D.2    Chen, S.3    Liu, X.4    Lin, L.5    Huang, X.6    Guo, Z.7    Liu, J.8    Wang, Y.9    Yuan, W.10    Qin, Y.11
  • 74
    • 84969921106 scopus 로고    scopus 로고
    • LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations
    • Wang, J., Ma, R., Ma, W., Chen, J., Yang, J., Xi, Y., Cui, Q., LncDisease: a sequence based bioinformatics tool for predicting lncRNA-disease associations. Nucleic Acids Res., 44, 2016, e90.
    • (2016) Nucleic Acids Res. , vol.44 , pp. e90
    • Wang, J.1    Ma, R.2    Ma, W.3    Chen, J.4    Yang, J.5    Xi, Y.6    Cui, Q.7
  • 75
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis—an inflammatory disease
    • Ross, R., Atherosclerosis—an inflammatory disease. N. Engl. J. Med. 340 (1999), 115–126.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 78
    • 84917729694 scopus 로고    scopus 로고
    • LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity
    • Wu, G., Cai, J., Han, Y., Chen, J., Huang, Z.-P., Chen, C., Cai, Y., Huang, H., Yang, Y., Liu, Y., et al. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation 130 (2014), 1452–1465.
    • (2014) Circulation , vol.130 , pp. 1452-1465
    • Wu, G.1    Cai, J.2    Han, Y.3    Chen, J.4    Huang, Z.-P.5    Chen, C.6    Cai, Y.7    Huang, H.8    Yang, Y.9    Liu, Y.10
  • 79
    • 84975290464 scopus 로고    scopus 로고
    • Association of lincRNA-p21 haplotype with coronary artery disease in a Chinese Han population
    • Tang, S.S., Cheng, J., Cai, M.Y., Yang, X.L., Liu, X.G., Zheng, B.Y., Xiong, X.D., Association of lincRNA-p21 haplotype with coronary artery disease in a Chinese Han population. Dis. Markers, 2016, 2016, 9109743.
    • (2016) Dis. Markers , vol.2016 , pp. 9109743
    • Tang, S.S.1    Cheng, J.2    Cai, M.Y.3    Yang, X.L.4    Liu, X.G.5    Zheng, B.Y.6    Xiong, X.D.7
  • 82
    • 84880748598 scopus 로고    scopus 로고
    • A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
    • Rapicavoli, N.A., Qu, K., Zhang, J., Mikhail, M., Laberge, R.-M., Chang, H.Y., A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. eLife, 2, 2013, e00762.
    • (2013) eLife , vol.2 , pp. e00762
    • Rapicavoli, N.A.1    Qu, K.2    Zhang, J.3    Mikhail, M.4    Laberge, R.-M.5    Chang, H.Y.6
  • 86
    • 84899894457 scopus 로고    scopus 로고
    • p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes
    • Krawczyk, M., Emerson, B.M., p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes. eLife, 3, 2014, e01776.
    • (2014) eLife , vol.3 , pp. e01776
    • Krawczyk, M.1    Emerson, B.M.2
  • 87
    • 84938906869 scopus 로고    scopus 로고
    • Cutting edge: a natural antisense transcript, AS-IL1α, controls inducible transcription of the proinflammatory cytokine IL-1α
    • Chan, J., Atianand, M., Jiang, Z., Carpenter, S., Aiello, D., Elling, R., Fitzgerald, K.A., Caffrey, D.R., Cutting edge: a natural antisense transcript, AS-IL1α, controls inducible transcription of the proinflammatory cytokine IL-1α. J. Immunol. 195 (2015), 1359–1363.
    • (2015) J. Immunol. , vol.195 , pp. 1359-1363
    • Chan, J.1    Atianand, M.2    Jiang, Z.3    Carpenter, S.4    Aiello, D.5    Elling, R.6    Fitzgerald, K.A.7    Caffrey, D.R.8
  • 89
  • 90
    • 84929946346 scopus 로고    scopus 로고
    • Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells
    • Puthanveetil, P., Chen, S., Feng, B., Gautam, A., Chakrabarti, S., Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells. J. Cell. Mol. Med. 19 (2015), 1418–1425.
    • (2015) J. Cell. Mol. Med. , vol.19 , pp. 1418-1425
    • Puthanveetil, P.1    Chen, S.2    Feng, B.3    Gautam, A.4    Chakrabarti, S.5
  • 91
    • 84925858306 scopus 로고    scopus 로고
    • Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus
    • Liu, J.Y., Yao, J., Li, X.M., Song, Y.C., Wang, X.Q., Li, Y.J., Yan, B., Jiang, Q., Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus. Cell Death Dis., 5, 2014, e1506.
    • (2014) Cell Death Dis. , vol.5 , pp. e1506
    • Liu, J.Y.1    Yao, J.2    Li, X.M.3    Song, Y.C.4    Wang, X.Q.5    Li, Y.J.6    Yan, B.7    Jiang, Q.8
  • 92
    • 84942898058 scopus 로고    scopus 로고
    • Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease
    • Yang, Y., Cai, Y., Wu, G., Chen, X., Liu, Y., Wang, X., Yu, J., Li, C., Chen, X., Jose, P.A., et al. Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease. Clin. Sci. 129 (2015), 675–685.
    • (2015) Clin. Sci. , vol.129 , pp. 675-685
    • Yang, Y.1    Cai, Y.2    Wu, G.3    Chen, X.4    Liu, Y.5    Wang, X.6    Yu, J.7    Li, C.8    Chen, X.9    Jose, P.A.10
  • 93
    • 85006108115 scopus 로고    scopus 로고
    • Circulating ‘lncRNA OTTHUMT00000387022’ from monocytes as a novel biomarker for coronary artery disease
    • Cai, Y., Yang, Y., Chen, X., Wu, G., Zhang, X., Liu, Y., Yu, J., Wang, X., Fu, J., Li, C., et al. Circulating ‘lncRNA OTTHUMT00000387022’ from monocytes as a novel biomarker for coronary artery disease. Cardiovasc. Res. 112 (2016), 714–724.
    • (2016) Cardiovasc. Res. , vol.112 , pp. 714-724
    • Cai, Y.1    Yang, Y.2    Chen, X.3    Wu, G.4    Zhang, X.5    Liu, Y.6    Yu, J.7    Wang, X.8    Fu, J.9    Li, C.10
  • 94
    • 84964066198 scopus 로고    scopus 로고
    • Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway
    • Zhou, X., Han, X., Wittfeldt, A., Sun, J., Liu, C., Wang, X., Gan, L.M., Cao, H., Liang, Z., Long non-coding RNA ANRIL regulates inflammatory responses as a novel component of NF-κB pathway. RNA Biol. 13 (2016), 98–108.
    • (2016) RNA Biol. , vol.13 , pp. 98-108
    • Zhou, X.1    Han, X.2    Wittfeldt, A.3    Sun, J.4    Liu, C.5    Wang, X.6    Gan, L.M.7    Cao, H.8    Liang, Z.9
  • 96
    • 40549109924 scopus 로고    scopus 로고
    • Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p
    • Broadbent, H.M., Peden, J.F., Lorkowski, S., Goel, A., Ongen, H., Green, F., Clarke, R., Collins, R., Franzosi, M.G., Tognoni, G., et al., PROCARDIS consortium. Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum. Mol. Genet. 17 (2008), 806–814.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 806-814
    • Broadbent, H.M.1    Peden, J.F.2    Lorkowski, S.3    Goel, A.4    Ongen, H.5    Green, F.6    Clarke, R.7    Collins, R.8    Franzosi, M.G.9    Tognoni, G.10
  • 100
    • 78650696753 scopus 로고    scopus 로고
    • Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk
    • Burd, C.E., Jeck, W.R., Liu, Y., Sanoff, H.K., Wang, Z., Sharpless, N.E., Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. PLoS Genet., 6, 2010, e1001233.
    • (2010) PLoS Genet. , vol.6 , pp. e1001233
    • Burd, C.E.1    Jeck, W.R.2    Liu, Y.3    Sanoff, H.K.4    Wang, Z.5    Sharpless, N.E.6
  • 102
    • 84887008398 scopus 로고    scopus 로고
    • The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10
    • Bochenek, G., Häsler, R., El Mokhtari, N.E., König, I.R., Loos, B.G., Jepsen, S., Rosenstiel, P., Schreiber, S., Schaefer, A.S., The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. Hum. Mol. Genet. 22 (2013), 4516–4527.
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 4516-4527
    • Bochenek, G.1    Häsler, R.2    El Mokhtari, N.E.3    König, I.R.4    Loos, B.G.5    Jepsen, S.6    Rosenstiel, P.7    Schreiber, S.8    Schaefer, A.S.9
  • 104
    • 77953096072 scopus 로고    scopus 로고
    • Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
    • Yap, K.L., Li, S., Muñoz-Cabello, A.M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M.J., Zhou, M.M., Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol. Cell 38 (2010), 662–674.
    • (2010) Mol. Cell , vol.38 , pp. 662-674
    • Yap, K.L.1    Li, S.2    Muñoz-Cabello, A.M.3    Raguz, S.4    Zeng, L.5    Mujtaba, S.6    Gil, J.7    Walsh, M.J.8    Zhou, M.M.9
  • 105
    • 79955468280 scopus 로고    scopus 로고
    • Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
    • Kotake, Y., Nakagawa, T., Kitagawa, K., Suzuki, S., Liu, N., Kitagawa, M., Xiong, Y., Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene 30 (2011), 1956–1962.
    • (2011) Oncogene , vol.30 , pp. 1956-1962
    • Kotake, Y.1    Nakagawa, T.2    Kitagawa, K.3    Suzuki, S.4    Liu, N.5    Kitagawa, M.6    Xiong, Y.7
  • 107
    • 80051679799 scopus 로고    scopus 로고
    • Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression
    • Aguilo, F., Zhou, M.M., Walsh, M.J., Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res. 71 (2011), 5365–5369.
    • (2011) Cancer Res. , vol.71 , pp. 5365-5369
    • Aguilo, F.1    Zhou, M.M.2    Walsh, M.J.3
  • 109
    • 79955103588 scopus 로고    scopus 로고
    • Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1
    • Tsuiji, H., Yoshimoto, R., Hasegawa, Y., Furuno, M., Yoshida, M., Nakagawa, S., Competition between a noncoding exon and introns: Gomafu contains tandem UACUAAC repeats and associates with splicing factor-1. Genes Cells 16 (2011), 479–490.
    • (2011) Genes Cells , vol.16 , pp. 479-490
    • Tsuiji, H.1    Yoshimoto, R.2    Hasegawa, Y.3    Furuno, M.4    Yoshida, M.5    Nakagawa, S.6
  • 115
    • 85019122822 scopus 로고    scopus 로고
    • Circular RNAs and heart failure: new players for an old disease
    • Elia, L., Quintavalle, M., Condorelli, G., Circular RNAs and heart failure: new players for an old disease. Cardiovasc. Res. 113 (2017), 254–255.
    • (2017) Cardiovasc. Res. , vol.113 , pp. 254-255
    • Elia, L.1    Quintavalle, M.2    Condorelli, G.3
  • 117
    • 84987657380 scopus 로고    scopus 로고
    • A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223
    • Wang, K., Long, B., Liu, F., Wang, J.X., Liu, C.Y., Zhao, B., Zhou, L.Y., Sun, T., Wang, M., Yu, T., et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur. Heart J. 37 (2016), 2602–2611.
    • (2016) Eur. Heart J. , vol.37 , pp. 2602-2611
    • Wang, K.1    Long, B.2    Liu, F.3    Wang, J.X.4    Liu, C.Y.5    Zhao, B.6    Zhou, L.Y.7    Sun, T.8    Wang, M.9    Yu, T.10
  • 118
    • 84962110904 scopus 로고    scopus 로고
    • The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression
    • Geng, H.H., Li, R., Su, Y.M., Xiao, J., Pan, M., Cai, X.X., Ji, X.P., The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. PLoS ONE, 11, 2016, e0151753.
    • (2016) PLoS ONE , vol.11 , pp. e0151753
    • Geng, H.H.1    Li, R.2    Su, Y.M.3    Xiao, J.4    Pan, M.5    Cai, X.X.6    Ji, X.P.7
  • 119
    • 84959420053 scopus 로고    scopus 로고
    • Circulating long noncoding RNA UCA1 as a novel biomarker of acute myocardial infarction
    • Yan, Y., Zhang, B., Liu, N., Qi, C., Xiao, Y., Tian, X., Li, T., Liu, B., Circulating long noncoding RNA UCA1 as a novel biomarker of acute myocardial infarction. BioMed Res. Int., 2016, 2016, 8079372.
    • (2016) BioMed Res. Int. , vol.2016 , pp. 8079372
    • Yan, Y.1    Zhang, B.2    Liu, N.3    Qi, C.4    Xiao, Y.5    Tian, X.6    Li, T.7    Liu, B.8
  • 120
    • 84927918639 scopus 로고    scopus 로고
    • Long non coding RNA-UCA1 contributes to cardiomyocyte apoptosis by suppression of p27 expression
    • Liu, Y., Zhou, D., Li, G., Ming, X., Tu, Yf., Tian, J., Lu, H., Yu, B., Long non coding RNA-UCA1 contributes to cardiomyocyte apoptosis by suppression of p27 expression. Cell. Physiol. Biochem. 35 (2015), 1986–1998.
    • (2015) Cell. Physiol. Biochem. , vol.35 , pp. 1986-1998
    • Liu, Y.1    Zhou, D.2    Li, G.3    Ming, X.4    Tu, Y.5    Tian, J.6    Lu, H.7    Yu, B.8
  • 121
    • 52949111864 scopus 로고    scopus 로고
    • Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure
    • Zolk, O., Solbach, T.F., Eschenhagen, T., Weidemann, A., Fromm, M.F., Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure. Biochem. Biophys. Res. Commun. 376 (2008), 315–320.
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , pp. 315-320
    • Zolk, O.1    Solbach, T.F.2    Eschenhagen, T.3    Weidemann, A.4    Fromm, M.F.5
  • 122
    • 77951915586 scopus 로고    scopus 로고
    • Autophagy during cardiac stress: joys and frustrations of autophagy
    • Gottlieb, R.A., Mentzer, R.M., Autophagy during cardiac stress: joys and frustrations of autophagy. Annu. Rev. Physiol. 72 (2010), 45–59.
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 45-59
    • Gottlieb, R.A.1    Mentzer, R.M.2
  • 123
    • 84863192578 scopus 로고    scopus 로고
    • Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury
    • Ma, X., Liu, H., Foyil, S.R., Godar, R.J., Weinheimer, C.J., Hill, J.A., Diwan, A., Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 125 (2012), 3170–3181.
    • (2012) Circulation , vol.125 , pp. 3170-3181
    • Ma, X.1    Liu, H.2    Foyil, S.R.3    Godar, R.J.4    Weinheimer, C.J.5    Hill, J.A.6    Diwan, A.7
  • 130
    • 84990177935 scopus 로고    scopus 로고
    • Long non-coding RNA-ROR mediates the reprogramming in cardiac hypertrophy
    • Jiang, F., Zhou, X., Huang, J., Long non-coding RNA-ROR mediates the reprogramming in cardiac hypertrophy. PLoS ONE, 11, 2016, e0152767.
    • (2016) PLoS ONE , vol.11 , pp. e0152767
    • Jiang, F.1    Zhou, X.2    Huang, J.3
  • 131
    • 44449141547 scopus 로고    scopus 로고
    • Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy
    • Murtaza, I., Wang, H.X., Feng, X., Alenina, N., Bader, M., Prabhakar, B.S., Li, P.F., Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. J. Biol. Chem. 283 (2008), 5996–6004.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5996-6004
    • Murtaza, I.1    Wang, H.X.2    Feng, X.3    Alenina, N.4    Bader, M.5    Prabhakar, B.S.6    Li, P.F.7
  • 132
    • 33645522627 scopus 로고    scopus 로고
    • Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress
    • Donath, S., Li, P., Willenbockel, C., Al-Saadi, N., Gross, V., Willnow, T., Bader, M., Martin, U., Bauersachs, J., Wollert, K.C., et al., German Heart Failure Network. Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress. Circulation 113 (2006), 1203–1212.
    • (2006) Circulation , vol.113 , pp. 1203-1212
    • Donath, S.1    Li, P.2    Willenbockel, C.3    Al-Saadi, N.4    Gross, V.5    Willnow, T.6    Bader, M.7    Martin, U.8    Bauersachs, J.9    Wollert, K.C.10
  • 133
    • 84892924162 scopus 로고    scopus 로고
    • Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality
    • Zsebo, K., Yaroshinsky, A., Rudy, J.J., Wagner, K., Greenberg, B., Jessup, M., Hajjar, R.J., Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality. Circ. Res. 114 (2014), 101–108.
    • (2014) Circ. Res. , vol.114 , pp. 101-108
    • Zsebo, K.1    Yaroshinsky, A.2    Rudy, J.J.3    Wagner, K.4    Greenberg, B.5    Jessup, M.6    Hajjar, R.J.7
  • 134
    • 47549106017 scopus 로고    scopus 로고
    • Optimizing gene delivery vectors for the treatment of heart disease
    • Gray, S.J., Samulski, R.J., Optimizing gene delivery vectors for the treatment of heart disease. Expert Opin. Biol. Ther. 8 (2008), 911–922.
    • (2008) Expert Opin. Biol. Ther. , vol.8 , pp. 911-922
    • Gray, S.J.1    Samulski, R.J.2
  • 135
    • 34250757582 scopus 로고    scopus 로고
    • Novel vectors for in vivo gene delivery to vascular tissue
    • White, K., Nicklin, S.A., Baker, A.H., Novel vectors for in vivo gene delivery to vascular tissue. Expert Opin. Biol. Ther. 7 (2007), 809–821.
    • (2007) Expert Opin. Biol. Ther. , vol.7 , pp. 809-821
    • White, K.1    Nicklin, S.A.2    Baker, A.H.3
  • 140
    • 84951938836 scopus 로고    scopus 로고
    • Gene therapy: progress and predictions
    • Collins, M., Thrasher, A., Gene therapy: progress and predictions. Proc. Biol. Sci., 282, 2015, 20143003.
    • (2015) Proc. Biol. Sci. , vol.282 , pp. 20143003
    • Collins, M.1    Thrasher, A.2
  • 141
    • 79961032369 scopus 로고    scopus 로고
    • Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure
    • Jessup, M., Greenberg, B., Mancini, D., Cappola, T., Pauly, D.F., Jaski, B., Yaroshinsky, A., Zsebo, K.M., Dittrich, H., Hajjar, R.J., Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) Investigators. Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 124 (2011), 304–313.
    • (2011) Circulation , vol.124 , pp. 304-313
    • Jessup, M.1    Greenberg, B.2    Mancini, D.3    Cappola, T.4    Pauly, D.F.5    Jaski, B.6    Yaroshinsky, A.7    Zsebo, K.M.8    Dittrich, H.9    Hajjar, R.J.10
  • 143
    • 77949512140 scopus 로고    scopus 로고
    • RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    • Bennett, C.F., Swayze, E.E., RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 50 (2010), 259–293.
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 259-293
    • Bennett, C.F.1    Swayze, E.E.2
  • 144
    • 70349328532 scopus 로고    scopus 로고
    • Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer
    • Fluiter, K., Mook, O.R., Vreijling, J., Langkjaer, N., Højland, T., Wengel, J., Baas, F., Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4′-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer. Mol. Biosyst. 5 (2009), 838–843.
    • (2009) Mol. Biosyst. , vol.5 , pp. 838-843
    • Fluiter, K.1    Mook, O.R.2    Vreijling, J.3    Langkjaer, N.4    Højland, T.5    Wengel, J.6    Baas, F.7
  • 145
    • 84966430344 scopus 로고    scopus 로고
    • Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides
    • Lennox, K.A., Behlke, M.A., Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides. Nucleic Acids Res. 44 (2016), 863–877.
    • (2016) Nucleic Acids Res. , vol.44 , pp. 863-877
    • Lennox, K.A.1    Behlke, M.A.2
  • 146
    • 84896505509 scopus 로고    scopus 로고
    • TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12
    • Fan, Y., Shen, B., Tan, M., Mu, X., Qin, Y., Zhang, F., Liu, Y., TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. Clin. Cancer Res. 20 (2014), 1531–1541.
    • (2014) Clin. Cancer Res. , vol.20 , pp. 1531-1541
    • Fan, Y.1    Shen, B.2    Tan, M.3    Mu, X.4    Qin, Y.5    Zhang, F.6    Liu, Y.7
  • 149
    • 13844272635 scopus 로고    scopus 로고
    • Synthetic hammerhead ribozymes as therapeutic tools to control disease genes
    • Citti, L., Rainaldi, G., Synthetic hammerhead ribozymes as therapeutic tools to control disease genes. Curr. Gene Ther. 5 (2005), 11–24.
    • (2005) Curr. Gene Ther. , vol.5 , pp. 11-24
    • Citti, L.1    Rainaldi, G.2
  • 150
    • 0034687544 scopus 로고    scopus 로고
    • Ribozyme to human TGF-beta1 mRNA inhibits the proliferation of human vascular smooth muscle cells
    • Su, J.Z., Fukuda, N., Hu, W.Y., Kanmatsuse, K., Ribozyme to human TGF-beta1 mRNA inhibits the proliferation of human vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 278 (2000), 401–407.
    • (2000) Biochem. Biophys. Res. Commun. , vol.278 , pp. 401-407
    • Su, J.Z.1    Fukuda, N.2    Hu, W.Y.3    Kanmatsuse, K.4
  • 154
    • 79551623370 scopus 로고    scopus 로고
    • ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS
    • Pasmant, E., Sabbagh, A., Vidaud, M., Bièche, I., ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 25 (2011), 444–448.
    • (2011) FASEB J. , vol.25 , pp. 444-448
    • Pasmant, E.1    Sabbagh, A.2    Vidaud, M.3    Bièche, I.4
  • 156
    • 84897030160 scopus 로고    scopus 로고
    • The four dimensions of noncoding RNA conservation
    • Diederichs, S., The four dimensions of noncoding RNA conservation. Trends Genet. 30 (2014), 121–123.
    • (2014) Trends Genet. , vol.30 , pp. 121-123
    • Diederichs, S.1
  • 157
    • 77951638287 scopus 로고    scopus 로고
    • Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor
    • Kino, T., Hurt, D.E., Ichijo, T., Nader, N., Chrousos, G.P., Noncoding RNA gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci. Signal., 3, 2010, ra8.
    • (2010) Sci. Signal. , vol.3 , pp. ra8
    • Kino, T.1    Hurt, D.E.2    Ichijo, T.3    Nader, N.4    Chrousos, G.P.5
  • 158
    • 84959451503 scopus 로고    scopus 로고
    • Advances in long noncoding RNAs: identification, structure prediction and function annotation
    • Guo, X., Gao, L., Wang, Y., Chiu, D.K., Wang, T., Deng, Y., Advances in long noncoding RNAs: identification, structure prediction and function annotation. Brief. Funct. Genomics 15 (2016), 38–46.
    • (2016) Brief. Funct. Genomics , vol.15 , pp. 38-46
    • Guo, X.1    Gao, L.2    Wang, Y.3    Chiu, D.K.4    Wang, T.5    Deng, Y.6
  • 159
    • 84893427735 scopus 로고    scopus 로고
    • In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
    • Ding, Y., Tang, Y., Kwok, C.K., Zhang, Y., Bevilacqua, P.C., Assmann, S.M., In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features. Nature 505 (2014), 696–700.
    • (2014) Nature , vol.505 , pp. 696-700
    • Ding, Y.1    Tang, Y.2    Kwok, C.K.3    Zhang, Y.4    Bevilacqua, P.C.5    Assmann, S.M.6
  • 161
    • 84895552736 scopus 로고    scopus 로고
    • Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support
    • Yang, K.C., Yamada, K.A., Patel, A.Y., Topkara, V.K., George, I., Cheema, F.H., Ewald, G.A., Mann, D.L., Nerbonne, J.M., Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support. Circulation 129 (2014), 1009–1021.
    • (2014) Circulation , vol.129 , pp. 1009-1021
    • Yang, K.C.1    Yamada, K.A.2    Patel, A.Y.3    Topkara, V.K.4    George, I.5    Cheema, F.H.6    Ewald, G.A.7    Mann, D.L.8    Nerbonne, J.M.9
  • 163
    • 84945124703 scopus 로고    scopus 로고
    • DECKO: single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs
    • Aparicio-Prat, E., Arnan, C., Sala, I., Bosch, N., Guigó, R., Johnson, R., DECKO: single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs. BMC Genomics, 16, 2015, 846.
    • (2015) BMC Genomics , vol.16 , pp. 846
    • Aparicio-Prat, E.1    Arnan, C.2    Sala, I.3    Bosch, N.4    Guigó, R.5    Johnson, R.6
  • 164
    • 84984873720 scopus 로고    scopus 로고
    • ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells
    • Müller, R., Weirick, T., John, D., Militello, G., Chen, W., Dimmeler, S., Uchida, S., ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells. Sci. Rep., 6, 2016, 32475.
    • (2016) Sci. Rep. , vol.6 , pp. 32475
    • Müller, R.1    Weirick, T.2    John, D.3    Militello, G.4    Chen, W.5    Dimmeler, S.6    Uchida, S.7
  • 165
    • 85016119895 scopus 로고    scopus 로고
    • ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data
    • Zhou, K.R., Liu, S., Sun, W.J., Zheng, L.L., Zhou, H., Yang, J.H., Qu, L.H., ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data. Nucleic Acids Res. 45 (2017), D43–D50.
    • (2017) Nucleic Acids Res. , vol.45 , pp. D43-D50
    • Zhou, K.R.1    Liu, S.2    Sun, W.J.3    Zheng, L.L.4    Zhou, H.5    Yang, J.H.6    Qu, L.H.7
  • 166
    • 84876566914 scopus 로고    scopus 로고
    • ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-seq data
    • Yang, J.H., Li, J.H., Jiang, S., Zhou, H., Qu, L.H., ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-seq data. Nucleic Acids Res. 41 (2013), D177–D187.
    • (2013) Nucleic Acids Res. , vol.41 , pp. D177-D187
    • Yang, J.H.1    Li, J.H.2    Jiang, S.3    Zhou, H.4    Qu, L.H.5
  • 167
    • 84976909135 scopus 로고    scopus 로고
    • deepBase v2.0: identification, expression, evolution and function of small RNAs, lncRNAs and circular RNAs from deep-sequencing data
    • Zheng, L.L., Li, J.H., Wu, J., Sun, W.J., Liu, S., Wang, Z.L., Zhou, H., Yang, J.H., Qu, L.H., deepBase v2.0: identification, expression, evolution and function of small RNAs, lncRNAs and circular RNAs from deep-sequencing data. Nucleic Acids Res. 44 (2016), D196–D202.
    • (2016) Nucleic Acids Res. , vol.44 , pp. D196-D202
    • Zheng, L.L.1    Li, J.H.2    Wu, J.3    Sun, W.J.4    Liu, S.5    Wang, Z.L.6    Zhou, H.7    Yang, J.H.8    Qu, L.H.9
  • 168
    • 75549084786 scopus 로고    scopus 로고
    • deepBase: a database for deeply annotating and mining deep sequencing data
    • Yang, J.H., Shao, P., Zhou, H., Chen, Y.Q., Qu, L.H., deepBase: a database for deeply annotating and mining deep sequencing data. Nucleic Acids Res. 38 (2010), D123–D130.
    • (2010) Nucleic Acids Res. , vol.38 , pp. D123-D130
    • Yang, J.H.1    Shao, P.2    Zhou, H.3    Chen, Y.Q.4    Qu, L.H.5
  • 169
    • 84943820623 scopus 로고    scopus 로고
    • Creating reference gene annotation for the mouse C57BL6/J genome assembly
    • Mudge, J.M., Harrow, J., Creating reference gene annotation for the mouse C57BL6/J genome assembly. Mamm. Genome 26 (2015), 366–378.
    • (2015) Mamm. Genome , vol.26 , pp. 366-378
    • Mudge, J.M.1    Harrow, J.2
  • 171
    • 85023613680 scopus 로고    scopus 로고
    • LincSNP 2.0: an updated database for linking disease-associated SNPs to human long non-coding RNAs and their TFBSs
    • Ning, S., Yue, M., Wang, P., Liu, Y., Zhi, H., Zhang, Y., Zhang, J., Gao, Y., Guo, M., Zhou, D., et al. LincSNP 2.0: an updated database for linking disease-associated SNPs to human long non-coding RNAs and their TFBSs. Nucleic Acids Res. 45 (2017), D74–D78.
    • (2017) Nucleic Acids Res. , vol.45 , pp. D74-D78
    • Ning, S.1    Yue, M.2    Wang, P.3    Liu, Y.4    Zhi, H.5    Zhang, Y.6    Zhang, J.7    Gao, Y.8    Guo, M.9    Zhou, D.10


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