Noncoding RNA Gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor

Science Signaling

Volumn 3, Issue 107, 2010, Pages

  Kino, Tomoshige ^a   Hurt, Darrell E ^a   Ichijo, Takamasa ^a   Nader, Nancy ^a   Chrousos, George P ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RESPONSE ELEMENT; GROWTH FACTOR; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA; BIRC3 PROTEIN, HUMAN; DNA; GLUCOCORTICOID; GROWTH ARREST SPECIFIC TRANSCRIPT 5; INHIBITOR OF APOPTOSIS PROTEIN; SMALL NUCLEOLAR RNA;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL NUCLEUS; CELL SURVIVAL; CYTOPLASM; GENE; GENE MUTATION; GROWTH ARREST SPECIFIC 5 GENE; HUMAN; HUMAN CELL; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; STARVATION; BINDING COMPETITION; CELL PROLIFERATION; CELL STRAIN HCT116; CHEMISTRY; CONFORMATION; CULTURE MEDIUM; DNA RESPONSIVE ELEMENT; DRUG EFFECT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; LEUKEMIA CELL LINE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; TWO HYBRID SYSTEM; WESTERN BLOTTING;

BINDING, COMPETITIVE; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CULTURE MEDIA; DEXAMETHASONE; DNA; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HCT116 CELLS; HELA CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INHIBITOR OF APOPTOSIS PROTEINS; JURKAT CELLS; NUCLEIC ACID CONFORMATION; RECEPTORS, GLUCOCORTICOID; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL NUCLEOLAR; RNA, UNTRANSLATED; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 77951638287     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000568     Document Type: Article

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56. This study was funded by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD. We thank R. M. Evans, F. French, G. L. Hager, Y. Shi, S. S. Simons Jr., J. A. Steitz, M.-J. Tsai, B. Vogelstein, and N. Warriar for providing the plasmids; R. J. Maraia and A. Porras for helpful discussion on the RNA fluorescent in situ hybridization; and M. K. Zachman for technical assistance.