A common allele on chromosome 9 associated with coronary heart disease

Science

Volumn 316, Issue 5830, 2007, Pages 1488-1491

  McPherson, Ruth ^a   Pertsemlidis, Alexander ^b   Kavaslar, Nihan ^a   Stewart, Alexandre ^a   Roberts, Robert ^a   Cox, David R ^c   Hinds, David A ^c   Pennacchio, Len A ^d,e   Tybjaerg Hansen, Anne ^f   Folsom, Aaron R ^g   Boerwinkle, Eric ^h   Hobbs, Helen H ^b   Cohen, Jonathan C ^b  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Perlegen Sciences Inc   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e DOE JOINT GENOME INSTITUTE   (United States)

^f International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^g UNIVERSITY OF MINNESOTA   (United States)

^h UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN;

ALLELE; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; CHROMOSOME; DIABETES; GENE EXPRESSION; GENOME; HYPERTENSION; PROTEIN; RISK FACTOR;

AGED; ALLELE; ARTICLE; CAUCASIAN; CAUSE OF DEATH; CDKN2A GENE; CDKN2B GENE; CHROMOSOME 9P; DIABETES MELLITUS; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOME ANALYSIS; HIGH RISK POPULATION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; ALLELES; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 9; CORONARY ARTERIOSCLEROSIS; CORONARY DISEASE; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENES, P16; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPORTIONAL HAZARDS MODELS; REGULATORY ELEMENTS, TRANSCRIPTIONAL; RISK FACTORS; RNA, UNTRANSLATED; VARIATION (GENETICS);

EID: 34249996115     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1142447     Document Type: Article

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13. We thank T. Hyatt, H. Doelle, T. Naing, L. Nie, K. Moller Rasmussen, M. Refstrup, W. S. Schackwitz, J. Martin, and A. Ustaszewska for excellent technical assistance and J. Schageman, C. Lee, K. Lawson, and K. Williams for statistical analyses. We are indebted to the staff and participants of the OHS, the DHS, the ARIC study, and the CCHS for their important contributions. Supported by grants from Foundation Le Ducq, the Donald W. Reynolds Foundation, NIH (HL-082896), the National Heart, Lung, and Blood Institute Program for Genomic Applications (no. HL-066681), the U.S. Department of Energy (contract no. DE-AC02-05CH11231), the Canadian Institutes of Health Research (no. 44360), the Canadian Foundation for Innovation, the Heart and Stroke Foundation of Ontario (no. NA-5413) the Danish Medical Research Council, the Danish Heart Foundation, and the Research Fund at Rigshospitalet, Copenhagen University Hospital. D.R.C. and D.A.H. have equity interest in Perlegen Sciences.