Long non coding RNA-UCA1 contributes to cardiomyocyte apoptosis by suppression of p27 expression

Cellular Physiology and Biochemistry

Volumn 35, Issue 5, 2015, Pages 1986-1998

  Liu, Youbin ^a   Zhou, Daliang ^b   Li, Guangnan ^a   Ming, Xing ^a   Tu, Ying Feng ^a   Tian, Jinwei ^a   Lu, Huimin ^a   Yu, Bo ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b First Hospital of Harbin   (China)

Author keywords

Cardiomyocyte apoptosis; Long non coding RNA; p27; UCA1

Indexed keywords

CASPASE 3; LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA UROTHELIAL CARCINOMA ASSOCIATED 1; PROTEIN BCL 2; PROTEIN P27; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HYDROGEN PEROXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; FOLLOW UP; GENETIC TRANSFECTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TUMOR SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DISEASE MODEL; DNA MICROARRAY; DRUG EFFECTS; GENETICS; MALE; METABOLISM; PATHOLOGY; REPERFUSION INJURY; RNA INTERFERENCE; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE MODELS, ANIMAL; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; MALE; MYOCYTES, CARDIAC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; RNA INTERFERENCE; RNA, LONG NONCODING;

EID: 84927918639     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374006     Document Type: Article

References (30)

1. Kalanuria AA, Nyquist P, Ling G: The prevention and regression of atherosclerotic plaques: emerging treatments. Vasc Health Risk Manag 2012;8:549-561.
2. Dabek J, Owczarek A, Gasior Z, Ulczok R, Skowerski M, Kulach A, Mazurek U, Bochenek A: Oligonucleotidemicroarray analysis of genes regulating apoptosis in chronically ischemic and postinfarction myocardium. Biochem Genet 2008;46:241-247.
3. Ordovas JM, Smith CE: Epigenetics and cardiovascular disease. Nat Rev Cardiol 2010;7:510-519.
4. Lee JH, Gao C, Peng G, Greer C, Ren S, Wang Y, Xiao X: Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts. Circ Res 2011;109:1332-1341.
5. Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM: Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 2007;12:215-229.
6. Rinn JL, Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem 2012;81:145-166.
7. Konstantinidis K, Whelan RS, Kitsis RN. Mechanisms of cell death in heart disease. Arterioscler Thromb Vasc Biol 2012;32:1552-1562.
8. Smith CC, Davidson SM, Lim SY, Simpkin JC, Hothersall JS, Yellon DM. Necrostatin: A potentially novel cardioprotective agent? Cardiovasc Drugs Ther 2007;21:227-233.
9. Accili D, Arden KC: Foxos at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004;117:421-426.
10. Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu M, Mo YY: Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 2014;5:e1008.
11. Hengst L, Reed SI: Translational control of p27Kip1 accumulation during the cell cycle. Science 1996;271:1861-1864.
12. Wander SA, Zhao D, Slingerland JM: p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies. Clin Cancer Res 2011;17:12-18.
13. Wang XS, Zhang Z, Wang HC, Cai JL, Xu QW, Li MQ: Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma. Clin Cancer Res 2006;12:4851-4858.
14. Tsang WP, Wong TW, Cheung AH, Co CN, Kwok TT: Induction of drug resistance and transformation in human cancer cells by the noncoding RNA CUDR. RNA 2007;13:890-898.
15. Liu Y, Li G, Lu H, Li W, Li X, Liu H, Li X, Li T, Yu B. Expression profiling and ontology analysis of long noncoding RNAs in post-ischemic heart and their implied roles in ischemia/reperfusion injury. Gene 2014;543:15-21.
16. Tan WQ, Wang K, Lv DY, Li PF: Foxo3a inhibits cardiomyocyte hypertrophy through transactivating catalase. J Biol Chem 2008;283:29730-29739
17. Braconi C, Valeri N, Kogure T, Gasparini P, Huang N, Nuovo GJ, Terracciano L, Croce CM, Patel T. Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc Natl Acad Sci U S A 2011;108:786-791.
18. Guo J, Li M, Meng X, Sui J, Dou L, Tang W, Huang X, Man Y, Wang S, Li J. MiR-291b-3p induces apoptosis in liver cell line NCTC1469 by reducing the level of RNA-bingding protein HuR. Cell Physiol Biochemistry. 2014;33:810-822.
19. Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, Yeh ET: Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med 2012;18:1639-1642.
20. Tuorkey MJ, EI-Desouki NI, Kamel RA: Cytoprotective effect of silymarin against diabetes-induced cardiomyocyte apoptosis in diabetic rats. Biomed Environ Sci 2015;28:36-43.
21. Di Gesualdo F, Capaccioli S, Lulli M: A pathophysiological view of the long non-coding RNA world. Oncotarget 2014;5:10976-10996.
22. Gazzaniga FS, Blackburn EH. An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. Blood 2014;124:3675-3684.
23. Lee B, Mazar J, Aftab MN, Qi F, Shelley J, Li JL, Govindarajan S, Valerio F, Rivera I, Thurn T, Tran TA, Kameh D, Patel V, Perera RJ: Long noncoding RNAs as putative biomarkers for prostate cancer detection. J Mol Diagn 2014;16:615-626.
24. Barnett P, van den Hoff MJ. Cardiac regeneration: different cells same goal. Med Biol Eng Comput 2011;49:723-32.
25. Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S: Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 2008;172:454-469.
26. Puyal J, Vaslin A, Mottier V, Clarke PG: Postischemic treatment of neonatal cerebral ischemia should target autophagy. Ann Neurol 2009;66:378-389.
27. Sun Y, Wang Y, Yin Y, Chen X, Sun Z : GSTM3 reverses the resistance of hepatoma cells to radiation by regulating the expression of cell cycle/apoptosis-related molecules. Oncol Lett 2014;8:1435-1440.
28. Wu S, Bao Y, Ma D, Zi Y, Yang C, Yang M, Xing M, Yang W: Sodium selenite inhibits leukemia HL-60 cell proliferation and induces cell apoptosis by enhancing the phosphorylation of JNK1 and increasing the expression of p21 and p27. Int J Mol Med 2014;34:1175-1179.
29. Slingerland J and Pagano M: Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol 2000;183:10-17.
30. Jatzek A, Tejera MM, Singh A, Sullivan JA, Plisch EH, Suresh M: p27(Kip1) negatively regulates the magnitude and persistence of CD4 T cell memory. J Immunol 2012;189:5119-5128.