Cutting edge: A natural antisense transcript, AS-IL-1α, controls inducible transcription of the proinflammatory cytokine IL-1α

Journal of Immunology

Volumn 195, Issue 4, 2015, Pages 1359-1363

  Chan, Jennie ^a   Atianand, Maninjay ^a   Jiang, Zhaozhao ^a   Carpenter, Susan ^a,b   Aiello, Daniel ^a   Elling, Roland ^a   FitzGerald, Katherine A ^a,c   Caffrey, Daniel R ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AS INTERLEUKIN 1ALPHA; INTERLEUKIN 1ALPHA; LONG UNTRANSLATED RNA; MESSENGER RNA; NATURAL ANTISENSE TRANSCRIPT; RNA POLYMERASE II; SHORT HAIRPIN RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; AUTACOID; COMPLEMENTARY RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; UNTRANSLATED RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC TRANSCRIPTION; IMMUNE RESPONSE; INNATE IMMUNITY; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; RNA STABILITY; ANIMAL; CELL LINE; CLUSTER ANALYSIS; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE LOCUS; GENE SILENCING; GENETICS; METABOLISM; RNA INTERFERENCE;

ANIMALS; CELL LINE; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENETIC LOCI; INFLAMMATION MEDIATORS; INTERLEUKIN-1ALPHA; LIGANDS; MACROPHAGES; MICE; NF-KAPPA B; RNA INTERFERENCE; RNA, ANTISENSE; RNA, UNTRANSLATED; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC;

EID: 84938906869     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500264     Document Type: Article

References (19)

1. RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium, S. Katayama, Y. Tomaru, T. Kasukawa, K. Waki, M. Nakanishi, M. Nakamura, H. Nishida, C. C. Yap, M. Suzuki, et al. 2005. Antisense transcription in the mammalian transcriptome. Science 309: 1564-1566.
2. Derrien, T., R. Johnson, G. Bussotti, A. Tanzer, S. Djebali, H. Tilgner, G. Guernec, D. Martin, A. Merkel, D. G. Knowles, et al. 2012. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 22: 1775-1789.
3. Carpenter, S., D. Aiello, M. K. Atianand, E. P. Ricci, P. Gandhi, L. L. Hall, M. Byron, B. Monks, M. Henry-Bezy, J. B. Lawrence, et al. 2013. A long noncoding RNA mediates both activation and repression of immune response genes. Science 341: 789-792.
4. Rinn, J. L., and H. Y. Chang. 2012. Genome regulation by long noncoding RNAs. Annu. Rev. Biochem. 81: 145-166.
5. Carpenter, S., and K. A. Fitzgerald. 2015. Transcription of inflammatory genes: long noncoding RNA and beyond. J. Interferon Cytokine Res. 35: 79-88.
6. Werner, A., M. Carlile, and D. Swan. 2009. What do natural antisense transcripts regulate? RNA Biol. 6: 43-48.
7. Matsui, K., M. Nishizawa, T. Ozaki, T. Kimura, I. Hashimoto, M. Yamada, M. Kaibori, Y. Kamiyama, S. Ito, and T. Okumura. 2008. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Hepatology 47: 686-697.
8. Vigetti, D., S. Deleonibus, P. Moretto, T. Bowen, J. W. Fischer, M. Grandoch, A. Oberhuber, D. C. Love, J. A. Hanover, R. Cinquetti, et al. 2014. Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation. J. Biol. Chem. 289: 28816-28826.
9. Hu, G., Q. Tang, S. Sharma, F. Yu, T. M. Escobar, S. A. Muljo, J. Zhu, and K. Zhao. 2013. Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation. Nat. Immunol. 14: 1190-1198.
10. Chen, C.-J., H. Kono, D. Golenbock, G. Reed, S. Akira, and K. L. Rock. 2007. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat. Med. 13: 851-856.
11. Kim, B., Y. Lee, E. Kim, A. Kwak, S. Ryoo, S. H. Bae, T. Azam, S. Kim, and C. A. Dinarello. 2013. The interleukin-1a precursor is biologically active and is likely a key alarmin in the IL-1 family of cytokines. Front. Immunol. 4: 391.
12. Severa, M., S. A. Islam, S. N. Waggoner, Z. Jiang, N. D. Kim, G. Ryan, E. Kurt-Jones, I. Charo, D. R. Caffrey, V. L. Boyartchuk, et al. 2014. The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8. J. Immunol. 192: 2291-2304.
13. Unterholzner, L., S. E. Keating, M. Baran, K. A. Horan, S. B. Jensen, S. Sharma, C. M. Sirois, T. Jin, E. Latz, T. S. Xiao, et al. 2010. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11: 997-1004.
14. Hornung, V., F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono, K. L. Rock, K. A. Fitzgerald, and E. Latz. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9: 847-856.
15. Dixit, E., S. Boulant, Y. Zhang, A. S. Lee, C. Odendall, B. Shum, N. Hacohen, Z. J. Chen, S. P. Whelan, M. Fransen, et al. 2010. Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141: 668-681.
16. Bhatt, D. M., A. Pandya-Jones, A.-J. Tong, I. Barozzi, M. M. Lissner, G. Natoli, D. L. Black, and S. T. Smale. 2012. Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell 150: 279-290.
17. Leber, J. H., G. T. Crimmins, S. Raghavan, N. P. Meyer-Morse, J. S. Cox, and D. A. Portnoy. 2008. Distinct TLR-and NLR-mediated transcriptional responses to an intracellular pathogen. PLoS Pathog. 4: e6.
18. Guttman, M., I. Amit, M. Garber, C. French, M. F. Lin, D. Feldser, M. Huarte, O. Zuk, B. W. Carey, J. P. Cassady, et al. 2009. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458: 223-227.
19. Atianand, M. K., and K. A. Fitzgerald. 2014. Long non-coding RNAs and control of gene expression in the immune system. Trends Mol. Med. 20: 623-631.