Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1

Circulation

Volumn 134, Issue 23, 2016, Pages 1848-1862

  Hadji, Fayez ^a   Boulanger, Marie Chloé ^a   Guay, Simon Pierre ^c,d   Gaudreault, Nathalie ^a   Amellah, Soumiya ^a   Mkannez, Guada ^a   Bouchareb, Rihab ^a   Marchand, Joël Tremblay ^b   Nsaibia, Mohamed Jalloul ^a   Guauque Olarte, Sandra ^b   Pibarot, Philippe ^a   Bouchard, Luigi ^c,d,e   Bossé, Yohan ^b   Mathieu, Patrick ^a  

^a LAVAL UNIVERSITY   (Canada)

^b Department of Molecular Medicine ^*  (Canada)

^c UNIVERSITÉ LAVAL   (Canada)

^d UNIVERSITY OF SHERBROOKE   (Canada)

^e CHICOUTIMI HOSPITAL   (Canada)

Author keywords

aortic valve; aortic valve stenosis; aortic valve, calcification of; core binding factor alpha 1 subunit; H19 long non coding RNA; receptor, notch1; RNA, long noncoding

Indexed keywords

APTAMER; BONE MORPHOGENETIC PROTEIN 2; LONG UNTRANSLATED RNA; NOTCH1 RECEPTOR; PROTEIN P53; RNA H19; TRANSCRIPTION FACTOR RUNX2; BMP2 PROTEIN, HUMAN; H19 LONG NON-CODING RNA; NOTCH1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ADULT; AGED; AORTA VALVE; AORTA VALVE DISEASE; ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CELL FATE; CHROMOSOME 11; CONFOCAL MICROSCOPE; CONTROLLED STUDY; DISEASE ACTIVITY; DNA METHYLATION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; LEYDIG CELL; MALE; MINERALIZATION; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; RNA SEQUENCE; UPREGULATION; ANTAGONISTS AND INHIBITORS; AORTIC VALVE; AORTIC VALVE STENOSIS; CALCINOSIS; CELL CULTURE; CYTOLOGY; GENETICS; HEK293 CELL LINE; METABOLISM; MIDDLE AGED; PATHOLOGY; REPORTER GENE; RNA INTERFERENCE;

AGED; AORTIC VALVE; AORTIC VALVE STENOSIS; BONE MORPHOGENETIC PROTEIN 2; CALCINOSIS; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DNA METHYLATION; FEMALE; GENES, REPORTER; HEK293 CELLS; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RECEPTOR, NOTCH1; RNA INTERFERENCE; RNA, LONG NONCODING; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84992732426     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.116.023116     Document Type: Article

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