Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice

Comparative Medicine

Volumn 58, Issue 4, 2008, Pages 341-346

  Shao, Wei Juan ^a   Tao, Ling Yun ^b   Gao, Cheng ^b   Xie, Jian Yun ^b   Zhao, Ru Qian ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b Shanghai Animal Disease Control Center   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BISULFITE; MESSENGER RNA; RNA H19; SOMATOMEDIN B; STREPTOZOCIN;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CPG ISLAND; DIABETES MELLITUS; DNA EXTRACTION; DNA METHYLATION; EMBRYO DEVELOPMENT; FEMALE; FETUS; FETUS DEVELOPMENT; GENE EXPRESSION; GENE SEQUENCE; GENOME IMPRINTING; METHYLATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION;

ADULT; ANIMALS; CPG ISLANDS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES, GESTATIONAL; DNA METHYLATION; ENDONUCLEASES; FEMALE; FETUS; GENOMIC IMPRINTING; HUMANS; INSULIN-LIKE GROWTH FACTOR II; MALE; MICE; PREGNANCY; PREGNANCY IN DIABETICS; RNA, UNTRANSLATED;

EID: 51549107100     PISSN: 15320820     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Aerts L, Holemans K, Van Assche FA. 1990. Impaired insulin response and action in offspring of severely diabetic rats. In: Frontiers in diabetes research. Lessons from animal diabetes, III. p 561-566.
2. Aerts L, Holemans K, Van Assche FA. 1990. Maternal diabetes during pregnancy: consequences for the offspring. Diabetes Metab Rev 6:147-167.
3. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. 1993. Type 2 (noninsulin-dependent) diabetes mellitus, hypertension, and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36:62-67.
4. Barlow DP. 1995. Gametic imprinting in mammals. Science 270:1610-1613.
5. Bartolomei MS, Zemel S, Tilghman SM. 1991. Parental imprinting of the mouse H19 gene. Nature 351:153-155.
6. Beebe LF, Kaye PL. 1991. Maternal diabetes and retarded preimplantation development of mice. Diabetes 40:457-461
7. Bestor TH. 2000. The DNA methyltransferases of mammals. Hum Mol Genet 9:2395-2402.
8. Cooney CA, Dave AA, Wolff GL. 2002. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 132 Suppl:2393S-2400S.
9. DeChiara TM, Efstratiadis A, Robertson EJ. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78-80.
10. DeChiara TM, Robertson EJ, Efstratiadis A. 1991. Parental imprinting of the mouse insulin-like growth factor II gene. Cell 64:849-859.
11. Delaval K, Feil R. 2004. Epigenetic regulation of mammalian genomic imprinting. Curr Opin Genet Dev 14:188-195.
12. Edwards CA, Ferguson-Smith AC. 2007. Mechanisms regulating imprinted genes in clusters. Curr Opin Cell Biol 19:281-289.
13. Feil R. 2006. Environmental and nutritional effects on the epigenetic regulation of genes. Mutat Res 600:46-57.
14. Gebert C, Wrenzycki C, Herrmann D, Groger D, Reinhardt R, Hajkova P, Lucas-Hahn A, Carnwath J, Lehrach H, Niemann H. 2006. The bovine IGF2 gene is differentially methylated in oocyte and sperm DNA. Genomics 88:222-229.
15. Gluckman PD, Hanson MA. 2004. Maternal constraint of fetal growth and its consequences. Semin Fetal Neonatal Med 9:419-425.
16. Gluckman PD, Harding J. 1997. Fetal growth retardation: underlying endocrine mechanisms and postnatal consequences. Acta Paediatr Suppl 422:69-72.
17. Holemans K, Aerts L, Van Assche FA. 2003. Fetal growth restriction an consequences for the offspring in animal models. J Soc Gynecol Investig 10:392-399.
18. Ito M, Kondo Y, Nakatani A, Hayashi K, Naruse A. 2001.Characterization of low dose streptozotocin-induced progressive diabetes in mice. Environ Toxicol Pharmacol 9:71-78.
19. Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E, Sasaki H. 2004. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429:900-903.
20. Katoh M, Curk T, Xu QK, Zupan B, Kuspa A, Shaulsky G. 2006. Developmentally regulated DNA methylation in dictyostelium discoideum. Eukaryot Cell 5:18-25.
21. Khosla S, Dean W, Brown D, Reik W, Feil R. 2001. Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes. Biol Reprod 64:918-926.
22. Kwong WY, Miller DJ, Ursell E, Wild AE, Wilkins AP, Osmond C. 2006. Imprinted gene expression in the rat embryo-fetal axis is altered in response to periconceptional maternal low protein diet. Reproduction 132:265-277.
23. Leighton PA, Saam JR, Ingram RS, Stewart CL, Tilghman SM. 1995. An enhancer deletion affects both H19 and Igf2 expression. Genes Dev 9:2079-2089.
24. Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. 2005. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135:1382-1386.
25. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408.
26. Martyn CN, Hales CN, Barker DJ, Jespersen S. 1998. Fetal growth and hyperinsulinaemia in adult life. Diabet Med 15:688-694.
27. Palomar-Morales M, Baiza LA, Verdín-Terán L, Román-Ramos R, Altamirano-Lozano M, Méndez JD. 1998. Fetal development in alloxan-treated rats. Reprod Toxicol 12:659-665.
28. Pembrey M. 1996. Imprinting and transgenerational modulation of gene expression: human growth as a model. Acta Genet Med Gemellol (Roma) 45:111-125.
29. Phelan SA, Ito M, Loeken MR. 1997. Neural tube defects in embryos of diabetic mice: role of the Pax3 gene and apoptosis. Diabetes 46:1189-1197.
30. Plagemann A, Harder T, Franke K, Kohlhoff R. 2002. Long-term impact of neonatal breast-feeding on body weight and glucose tolerance in children of diabetic mothers. Diabetes Care 25:16-22.
31. Reece EA, Ji I, Wu YK, Zhao Z. 2006. Characterization of differential gene expression profiles in diabetic embryopathy using DNA microarray analysis. Am J Obstet Gynecol 195:1075-1080.
32. Rees WD, Hay SM, Brown DS, Antipatis C, Palmer RM. 2000. Maternal protein deficiency causes hypermethylation of DNA in the livers of rat fetuses. J Nutr 130:1821-1826.
33. Ross MG, Desai M, Khorram O, McKnight RA, Lane RH, Torday J. 2007. Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease. Curr Alzheimer Res 4:213-217.
34. Serman A, Vlahovic M, Serman L, Bulic-Jakus F. 2006. DNA methylation as a regulatory mechanism for gene expression in mammals. Coll Antropol 30:665-671.
35. Smith FM, Garfield AS, Ward A. 2006. Regulation of growth and metabolism by imprinted genes. Cytogenet Genome Res 113:279-291.
36. Thompson SL, Konfortova G, Gregory RI, Reik W, Dean W, Feil R. 2001. Environmental effects on genomic imprinting in mammals. Toxicol Lett 120:143-150.
37. Thorvaldsen JL, Duran KL, Bartolomei MS. 1998. Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2. Genes Dev 12:3693-3702.
38. Tremblay KD, Duran KL, Bartolomei MS. 1997. A 5′ 2-kb region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol Cell Biol 17:4322-4329.
39. Waterland RA, Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23:5293-5300.
40. Waterland RA, Jirtle RL. 2004. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20:63-68.
41. Waterland RA, Dolinoy DC, Lin JR, Smith CA, Shi X, Tahiliani KG. 2006a. Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis 44:401-406.
42. Waterland RA, Lin JR, Smith CA, Jirtle RL. 2006b. Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet 15:705-716.
43. Weber M, Milligan L, Delalbre A, Antoine E, Brunel C, Cathala G, Forne T. 2001. Extensive tissue-specifc variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting. Mech Dev 101:133-141.
44. Wentzel P, Wentzel CR, Gareskog MB, Eriksson UJ. 2001. Induction of embryonic dysmorphogenesis by high glucose concentration, disturbed inositol metabolism, and inhibited protein kinase C activity. Teratology 63:193-201.
45. Wu Q, Ohsako S, Ishimura R, Suzuki JS, Tohyama C. 2004. Exposure of mouse preimplantation embryos to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the methylation status of imprinted genes H19 and Igf2. Biol Reprod 70:1790-1797.
46. Zhao Z, Reece EA. 2005. Experimental mechanisms of diabetic embryopathyand strategies for developing therapeutic interventions. J Soc Gynecol Investig 12:549-557.
47. Zhu B, Huang XH, Chen JD, Lu YC, Chen Y, Zhao JY. 2006. Methylation changes of H19 gene in sperms of X-irradiated mouse and maintenance in offspring. Biochem Biophys Res Commun 340:83-89.