Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure

Biochemical and Biophysical Research Communications

Volumn 376, Issue 2, 2008, Pages 315-320

  Zolk, Oliver ^a   Solbach, Thomas F ^a   Eschenhagen, Thomas ^b   Weidemann, Alexander ^c   Fromm, Martin F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Dilated cardiomyopathy; Heart failure; HIF antisense transcript; HIF prolyl hydroxylase; Human study; Hypoxia inducible factor; Hypoxia inducible factor 1 subunit inhibitor; Ischemic cardiomyopathy

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART FAILURE; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN TISSUE; HYPOXIA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARDIOMYOPATHY, DILATED; CHRONIC DISEASE; FEEDBACK, BIOCHEMICAL; GENE EXPRESSION REGULATION; HEART FAILURE; HEART VENTRICLES; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, ANTISENSE; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 52949111864     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.08.152     Document Type: Article

References (34)

1. Semenza G.L. HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107 (2001) 1-3
2. Weidemann A., and Johnson R.S. Biology of HIF-1alpha. Cell Death Differ. 15 (2008) 621-627
3. Maynard M.A., Evans A.J., Hosomi T., Hara S., Jewett M.A., and Ohh M. Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. FASEB J. 19 (2005) 1396-1406
4. Hara S., Hamada J., Kobayashi C., Kondo Y., and Imura N. Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. Biochem. Biophys. Res. Commun. 287 (2001) 808-813
5. Siddiq A., Aminova L.R., and Ratan R.R. Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress. Neurochem. Res. 32 (2007) 931-946
6. Rohrbach S., Simm A., Pregla R., Franke C., and Katschinski D.M. Age-dependent increase of prolyl-4-hydroxylase domain (PHD) 3 expression in human and mouse heart. Biogerontology 6 (2005) 165-171
7. Lieb M.E., Menzies K., Moschella M.C., Ni R., and Taubman M.B. Mammalian EGLN genes have distinct patterns of mRNA expression and regulation. Biochem. Cell Biol. 80 (2002) 421-426
8. Willam C., Maxwell P.H., Nichols L., Lygate C., Tian Y.M., Bernhardt W., Wiesener M., Ratcliffe P.J., Eckardt K.U., and Pugh C.W. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. J. Mol. Cell Cardiol. 41 (2006) 68-77
9. Berta M.A., Mazure N., Hattab M., Pouyssegur J., and Brahimi-Horn M.C. SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. Biochem. Biophys. Res. Commun. 360 (2007) 646-652
10. Semenza G.L., and Wang G.L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell Biol. 12 (1992) 5447-5454
11. Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., and Semenza G.L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16 (1996) 4604-4613
12. Kothari S., Cizeau J., Millan-Ward E., Israels S.J., Bailes M., Ens K., Kirshenbaum L.A., and Gibson S.B. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 22 (2003) 4734-4744
13. Ikeda R., Tajitsu Y., Iwashita K.I., Che X.F., Yoshida K., Ushiyama M., Furukawa T., Komatsu M., Yamaguchi T., Shibayama Y., Yamamoto M., Zhao H.Y., Arima J., Takeda Y., Akiyama S.I., and Yamada K. Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3. Biochem. Biophys. Res. Commun. 370 (2008) 220-224
14. Martin C.M., Ferdous A., Gallardo T., Humphries C., Sadek H., Caprioli A., Garcia J.A., Szweda L.I., Garry M.G., and Garry D.J. Hypoxia-inducible factor-2α transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ. Res. 102 (2008) 1075-1081
15. Thrash-Bingham C.A., and Tartof K.D. aHIF: a natural antisense transcript overexpressed in human renal cancer and during hypoxia. J. Natl. Cancer Inst. 91 (1999) 143-151
16. Cayre A., Rossignol F., Clottes E., and Penault-Llorca F. aHIF but not HIF-1alpha transcript is a poor prognostic marker in human breast cancer. Breast Cancer Res. 5 (2003) R223-R230
17. Date T., Mochizuki S., Belanger A.J., Yamakawa M., Luo Z., Vincent K.A., Cheng S.H., Gregory R.J., and Jiang C. Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury. Am. J. Physiol. Cell Physiol. 288 (2005) C314-C320
18. Huang Y., Hickey R.P., Yeh J.L., Liu D., Dadak A., Young L.H., Johnson R.S., and Giordano F.J. Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart. FASEB J. 18 (2004) 1138-1140
19. Lei L., Mason S., Liu D., Huang Y., Marks C., Hickey R., Jovin I.S., Pypaert M., Johnson R.S., and Giordano F.J. Hypoxia inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol. Cell Biol. 28 (2008) 3790-3803
20. Zolk O., Frohme M., Maurer A., Kluxen F.W., Hentsch B., Zubakov D., Hoheisel J.D., Zucker I.H., Pepe S., and Eschenhagen T. Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. Biochem. Biophys. Res. Commun. 293 (2002) 1377-1382
21. Solbach T.F., Paulus B., Weyand M., Eschenhagen T., Zolk O., and Fromm M.F. ATP-binding cassette transporters in human heart failure. Naunyn Schmiedebergs Arch. Pharmacol. 377 (2008) 231-243
22. Kakinuma Y., Miyauchi T., Yuki K., Murakoshi N., Goto K., and Yamaguchi I. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism. Circulation 103 (2001) 2387-2394
23. Lee S.H., Wolf P.L., Escudero R., Deutsch R., Jamieson S.W., and Thistlethwaite P.A. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N. Engl. J. Med. 342 (2000) 626-633
24. Heidbreder M., Frohlich F., Johren O., Dendorfer A., Qadri F., and Dominiak P. Hypoxia rapidly activates HIF-3alpha mRNA expression. FASEB J. 17 (2003) 1541-1543
25. Marfella R., Esposito K., Nappo F., Siniscalchi M., Sasso F.C., Portoghese M., Di Marino M.P., Baldi A., Cuzzocrea S., Di F.C., Barboso G., Baldi F., Rossi F., D'Amico M., and Giugliano D. Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes. Diabetes 53 (2004) 2383-2391
26. Kido M., Du L., Sullivan C.C., Li X., Deutsch R., Jamieson S.W., and Thistlethwaite P.A. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J. Am. Coll. Cardiol. 46 (2005) 2116-2124
27. Uchida T., Rossignol F., Matthay M.A., Mounier R., Couette S., Clottes E., and Clerici C. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. J. Biol. Chem. 279 (2004) 14871-14878
28. Kim C.H., Cho Y.S., Chun Y.S., Park J.W., and Kim M.S. Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway. Circ. Res. 90 (2002) E25-E33
29. Nguyen S.V., and Claycomb W.C. Hypoxia regulates the expression of the adrenomedullin and HIF-1 genes in cultured HL-1 cardiomyocytes. Biochem. Biophys. Res. Commun. 265 (1999) 382-386
30. Zhu B.L., Tanaka S., Ishikawa T., Zhao D., Li D.R., Michiue T., Quan L., and Maeda H. Forensic pathological investigation of myocardial hypoxia-inducible factor-1alpha, erythropoietin and vascular endothelial growth factor in cardiac death. Leg. Med. 10 (2008) 11-19
31. Marzo F., Lavorgna A., Coluzzi G., Santucci E., Tarantino F., Rio T., Conti E., Autore C., Agati L., and Andreotti F. Erythropoietin in heart and vessels: focus on transcription and signalling pathways. J. Thromb. Thrombolysis. (2008) 10.1007/s11239-008-0212-3
32. Cioffi C.L., Liu X.Q., Kosinski P.A., Garay M., and Bowen B.R. Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochem. Biophys. Res. Commun. 303 (2003) 947-953
33. Sabbah H.N., Sharov V.G., Lesch M., and Goldstein S. Progression of heart failure: a role for interstitial fibrosis. Mol. Cell Biochem. 147 (1995) 29-34
34. Anversa P., Loud A.V., Levicky V., and Guideri G. Left ventricular failure induced by myocardial infarction. II. Tissue morphometry. Am. J. Physiol. 248 (1985) H883-H889