Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

American Journal of Human Genetics

Volumn 94, Issue 3, 2014, Pages 349-360

  Tragante, Vinicius ^a   Barnes, Michael R ^b   Ganesh, Santhi K ^c   Lanktree, Matthew B ^d   Guo, Wei ^e   Franceschini, Nora ^f   Smith, Erin N ^g   Johnson, Toby ^b   Holmes, Michael V ^h   Padmanabhan, Sandosh ⁱ   Karczewski, Konrad J ^j   Almoguera, Berta ^k   Barnard, John ^l   Baumert, Jens ^m   Chang, Yen Pei Christy ⁿ   Elbers, Clara C ^a   Farrall, Martin ^o,p   Fischer, Mary E ^q   Gaunt, Tom R ^r   Gho, Johannes M I H ^a   Gieger, Christian ^m   Goel, Anuj ^o,p   Gong, Yan ^s   Isaacs, Aaron ^t   Kleber, Marcus E ^u   Leach, Irene Mateo ^v   McDonough, Caitrin W ^s   Meijs, Matthijs F L ^a   Melander, Olle ^w,x   Nelson, Christopher P ^y,z   Nolte, Ilja M ^v   Pankratz, Nathan ^aa   Price, Tom S ^ab   Shaffer, Jonathan ^ac   Shah, Sonia ^ad   Tomaszewski, Maciej ^y   Van Der Most, Peter J ^v   Van Iperen, Erik P A ^ae,af   Vonk, Judith M ^v   Witkowska, Kate ^b   Wong, Caroline O L ^b   Zhang, Li ^l   Beitelshees, Amber L ⁿ   Berenson, Gerald S ^ag   Bhatt, Deepak L ^ah   Brown, Morris ^ai   Burt, Amber ^aj   Cooper Dehoff, Rhonda M ^s   Connell, John M ^ak   Cruickshanks, Karen J ^q   Curtis, Sean P ^al   Davey Smith, George ^r   Delles, Christian ^am   Gansevoort, Ron T ^v   Guo, Xiuqing ^an   Haiqing, Shen ⁿ   Hastie, Claire E ^am   Hofker, Marten H ^a,v   Hovingh, G Kees ^af   Kim, Daniel S ^aj   Kirkland, Susan A ^ao   Klein, Barbara E ^q   Klein, Ronald ^q   Li, Yun R ^k   Maiwald, Steffi ^af   Newton Cheh, Christopher ^ap   O'Brien, Eoin T ^aq   Onland Moret, N Charlotte ^a   Palmas, Walter ^ac   Parsa, Afshin ⁿ   Penninx, Brenda W ^ar   Pettinger, Mary ^as   Vasan, Ramachandran S ^at   Ranchalis, Jane E ^aj   M Ridker, Paul ^ah,au   Rose, Lynda M ^ah   Sever, Peter ^av   Shimbo, Daichi ^ac   Steele, Laura ^h   Stolk, Ronald P ^v   Thorand, Barbara ^m   Trip, Mieke D ^af   Van Duijn, Cornelia M ^t   Verschuren, W Monique ^a,aw   Wijmenga, Cisca ^v   Wyatt, Sharon ^ax   Young, J Hunter ^ay   Zwinderman, Aeilko H ^af   Bezzina, Connie R ^af   Boerwinkle, Eric ^az   Casas, Juan P ^ad,ba   Caulfield, Mark J ^b   Chakravarti, Aravinda ^ay   Chasman, Daniel I ^ah,au   Davidson, Karina W ^ac   Doevendans, Pieter A ^a   Dominiczak, Anna F ⁱ   Fitzgerald, Garret A ^h   Gums, John G ^bb   Fornage, Myriam ^bc   Hakonarson, Hakon ^h,k   Halder, Indrani ^bd   Hillege, Hans L ^v   Illig, Thomas ^m,be   Jarvik, Gail P ^av   Johnson, Julie A ^s   Kastelein, John J P ^af   Koenig, Wolfgang ^bf   Kumari, Meena ^ad   März, Winfried ^u,bg,bh   Murray, Sarah S ^bi   O'Connell, Jeffery R ⁿ   Oldehinkel, Albertine J ^v   Pankow, James S ^bj   Rader, Daniel J ^h   Redline, Susan ^ah   Reilly, Muredach P ^h   Schadt, Eric E ^bk   Kottke Marchant, Kandice ^l   Snieder, Harold ^v   Snyder, Michael ^j   Stanton, Alice V ^bl   Tobin, Martin D ^y   Uitterlinden, André G ^t   Van Der Harst, Pim ^v,ae   Van Der Schouw, Yvonne T ^a   Samani, Nilesh J ^y,z   Watkins, Hugh ^o,p   Johnson, Andrew D ^bm   Reiner, Alex P ^as   Zhu, Xiaofeng ^e   De Bakker, Paul I W ^a,ah,ap   Levy, Daniel ^bn   Asselbergs, Folkert W ^a,ad,ae   Munroe, Patricia B ^b   Keating, Brendan J ^h,k   more..

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d MCMASTER UNIVERSITY   (Canada)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f IL   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^h UNIVERSITY OF PENNSYLVANIA   (United States)

ⁱ UNIVERSITY OF GLASGOW   (United Kingdom)

^j STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^l LERNER RESEARCH INSTITUTE   (United States)

^m INSTITUTE OF EPIDEMIOLOGY   (Germany)

ⁿ UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^o UNIVERSITY OF OXFORD   (United Kingdom)

^p UNIVERSITY OF OXFORD   (United Kingdom)

^q UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^r UNIVERSITY OF BRISTOL   (United Kingdom)

^s UNIVERSITY OF FLORIDA   (United States)

^t ERASMUS MEDICAL CENTER   (Netherlands)

^u MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^v UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^w LUND UNIVERSITY   (Sweden)

^x LUND UNIVERSITY HOSPITAL   (Sweden)

^y UNIVERSITY OF LEICESTER   (United Kingdom)

^z GLENFIELD HOSPITAL   (United Kingdom)

^aa UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^ab MEDICAL RESEARCH COUNCIL   (United Kingdom)

^ac Och Spine at New York Presbyterian Hospitals   (United States)

^ad UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ae ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^af ACADEMIC MEDICAL CENTER   (Netherlands)

^ag TULANE UNIVERSITY   (United States)

^ah BRIGHAM AND WOMEN S HOSPITAL   (United States)

^ai UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^aj UNIVERSITY OF WASHINGTON   (United States)

^ak UNIVERSITY OF DUNDEE   (United Kingdom)

^al MERCK RESEARCH LABORATORIES   (United States)

^am UNIVERSITY OF GLASGOW   (United Kingdom)

^an CEDARS SINAI MEDICAL CENTER   (United States)

^ao DALHOUSIE UNIVERSITY   (Canada)

^ap BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^aq UNIVERSITY COLLEGE DUBLIN   (Ireland)

^ar VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^as Fred Hutchinson Cancer Research Center   (United States)

^at BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^au HARVARD MEDICAL SCHOOL   (United States)

^av IMPERIAL COLLEGE LONDON   (United Kingdom)

^aw NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^ax UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^ay JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^az UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^ba LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^bb UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^bc UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^bd UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^be HANNOVER MEDICAL SCHOOL   (Germany)

^bf UNIVERSITY HOSPITAL ULM   (Germany)

^bg SYNLAB ACADEMY   (Germany)

^bh MEDICAL UNIVERSITY OF GRAZ   (Austria)

^bi UNIVERSITY OF CALIFORNIA   (United States)

^bj UNIVERSITY OF MINNESOTA   (United States)

^bk MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^bl ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^bm FRAMINGHAM HEART STUDY   (United States)

^bn NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; HLA DRB4 ANTIGEN; TRANSCRIPTION FACTOR RELA;

ARTICLE; BIOINFORMATICS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIASTOLIC BLOOD PRESSURE; DRUG RESPONSE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; MEAN ARTERIAL PRESSURE; META ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; PULSE PRESSURE; QUANTITATIVE TRAIT LOCUS; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

ARTERIAL PRESSURE; BLOOD PRESSURE; COMPUTATIONAL BIOLOGY; DIASTOLE; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC LOCI; GENETICS, POPULATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUALITY CONTROL; QUANTITATIVE TRAIT LOCI; RISK FACTORS; SYSTOLE;

EID: 84895920262     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2013.12.016     Document Type: Article

References (114)

1. P.W. Wilson Established risk factors and coronary artery disease: the Framingham Study Am. J. Hypertens. 7 1994 7S 12S
2. C.M.M. Lawes, S. Vander Hoorn, A. Rodgers International Society of Hypertension Global burden of blood-pressure-related disease, 2001 Lancet 371 2008 1513 1518
3. D. Levy, A.L. DeStefano, M.G. Larson, C.J. O'Donnell, R.P. Lifton, H. Gavras, L.A. Cupples, and R.H. Myers Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study Hypertension 36 2000 477 483
4. N. Kupper, G. Willemsen, H. Riese, D. Posthuma, D.I. Boomsma, and E.J. de Geus Heritability of daytime ambulatory blood pressure in an extended twin design Hypertension 45 2005 80 85
5. D. Levy, G.B. Ehret, K. Rice, G.C. Verwoert, L.J. Launer, A. Dehghan, N.L. Glazer, A.C. Morrison, A.D. Johnson, and T. Aspelund et al. Genome-wide association study of blood pressure and hypertension Nat. Genet. 41 2009 677 687
6. S. Padmanabhan, C. Newton-Cheh, and A.F. Dominiczak Genetic basis of blood pressure and hypertension Trends Genet. 28 2012 397 408
7. N. Franceschini, A.P. Reiner, and G. Heiss Recent findings in the genetics of blood pressure and hypertension traits Am. J. Hypertens. 24 2011 392 400
8. S.K. Ganesh, V. Tragante, W. Guo, Y. Guo, M.B. Lanktree, E.N. Smith, T. Johnson, B.A. Castillo, J. Barnard, J. Baumert CARDIOGRAM, METASTROKE LifeLines Cohort Study Loci influencing blood pressure identified using a cardiovascular gene-centric array Hum. Mol. Genet. 22 2013 1663 1678
9. G.B. Ehret, P.B. Munroe, K.M. Rice, M. Bochud, A.D. Johnson, D.I. Chasman, A.V. Smith, M.D. Tobin, G.C. Verwoert, S.J. Hwang International Consortium for Blood Pressure Genome-Wide Association Studies CARDIoGRAM consortium CKDGen Consortium KidneyGen Consortium EchoGen consortium CHARGE-HF consortium Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk Nature 478 2011 103 109
10. C. Newton-Cheh, T. Johnson, V. Gateva, M.D. Tobin, M. Bochud, L. Coin, S.S. Najjar, J.H. Zhao, S.C. Heath, S. Eyheramendy Wellcome Trust Case Control Consortium Genome-wide association study identifies eight loci associated with blood pressure Nat. Genet. 41 2009 666 676
11. T. Johnson, T.R. Gaunt, S.J. Newhouse, S. Padmanabhan, M. Tomaszewski, M. Kumari, R.W. Morris, I. Tzoulaki, E.T. O'Brien, N.R. Poulter Cardiogenics Consortium Global BPgen Consortium Blood pressure loci identified with a gene-centric array Am. J. Hum. Genet. 89 2011 688 700
12. X. Zhu, J.H. Young, E. Fox, B.J. Keating, N. Franceschini, S. Kang, B. Tayo, A. Adeyemo, Y.V. Sun, and Y. Li et al. Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium Hum. Mol. Genet. 20 2011 2285 2295
13. W. Zhan, K.J. Cruickshanks, B.E.K. Klein, R. Klein, G.-H. Huang, J.S. Pankow, R.E. Gangnon, and T.S. Tweed Generational differences in the prevalence of hearing impairment in older adults Am. J. Epidemiol. 171 2010 260 266
14. B.J. Keating, S. Tischfield, S.S. Murray, T. Bhangale, T.S. Price, J.T. Glessner, L. Galver, J.C. Barrett, S.F. Grant, and D.N. Farlow et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies PLoS ONE 3 2008 e3583
15. M. Tomaszewski, R. Debiec, P.S. Braund, C.P. Nelson, R. Hardwick, P. Christofidou, M. Denniff, V. Codd, S. Rafelt, and P. van der Harst et al. Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array Hypertension 56 2010 1069 1076
16. R. Clarke, J.F. Peden, J.C. Hopewell, T. Kyriakou, A. Goel, S.C. Heath, S. Parish, S. Barlera, M.G. Franzosi, S. Rust PROCARDIS Consortium Genetic variants associated with Lp(a) lipoprotein level and coronary disease N. Engl. J. Med. 361 2009 2518 2528
17. IBC 50K CAD Consortium Large-scale gene-centric analysis identifies novel variants for coronary artery disease PLoS Genet. 7 2011 e1002260
18. F.W. Asselbergs, Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. Tragante, M.B. Lanktree, L.A. Lange, B. Almoguera, Y.E. Appelman, J. Barnard LifeLines Cohort Study Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci Am. J. Hum. Genet. 91 2012 823 838
19. T.P. Cappola, M. Li, J. He, B. Ky, J. Gilmore, L. Qu, B. Keating, M. Reilly, C.E. Kim, and J. Glessner et al. Common variants in HSPB7 and FRMD4B associated with advanced heart failure Circ Cardiovasc Genet 3 2010 147 154
20. R. Saxena, C.C. Elbers, Y. Guo, I. Peter, T.R. Gaunt, J.L. Mega, M.B. Lanktree, A. Tare, B.A. Castillo, Y.R. Li Look AHEAD Research Group DIAGRAM consortium Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci Am. J. Hum. Genet. 90 2012 410 425
21. Y. Guo, M.B. Lanktree, K.C. Taylor, H. Hakonarson, L.A. Lange, B.J. Keating IBC 50K SNP array BMI Consortium Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals Hum. Mol. Genet. 22 2013 184 201
22. A.D. Johnson, C. Newton-Cheh, D.I. Chasman, G.B. Ehret, T. Johnson, L. Rose, K. Rice, G.C. Verwoert, L.J. Launer, V. Gudnason Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium Global BPgen Consortium Women's Genome Health Study Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals Hypertension 57 2011 903 910
23. P.I.W. de Bakker, M.A.R. Ferreira, X. Jia, B.M. Neale, S. Raychaudhuri, and B.F. Voight Practical aspects of imputation-driven meta-analysis of genome-wide association studies Hum. Mol. Genet. 17 R2 2008 R122 R128
24. G.A. Heap, G. Trynka, R.C. Jansen, M. Bruinenberg, M.A. Swertz, L.C. Dinesen, K.A. Hunt, C. Wijmenga, D.A. Vanheel, and L. Franke Complex nature of SNP genotype effects on gene expression in primary human leucocytes BMC Med. Genomics 2 2009 1
25. K.S. Lo, J.G. Wilson, L.A. Lange, A.R. Folsom, G. Galarneau, S.K. Ganesh, S.F. Grant, B.J. Keating, S.A. McCarroll, and E.R. Mohler 3rd et al. Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans Hum. Genet. 129 2011 307 317
26. A.D. Johnson, R.E. Handsaker, S.L. Pulit, M.M. Nizzari, C.J. O'Donnell, and P.I. de Bakker SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap Bioinformatics 24 2008 2938 2939
27. P.M. Ridker, D.I. Chasman, R.Y. Zee, A. Parker, L. Rose, N.R. Cook, J.E. Buring Women's Genome Health Study Working Group Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women Clin. Chem. 54 2008 249 255
28. G.F. Diercks, A.J. van Boven, H.L. Hillege, W.M. Janssen, J.A. Kors, P.E. de Jong, D.E. Grobbee, H.J. Crijns, and W.H. van Gilst Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study Eur. Heart J. 21 2000 1922 1927
29. R.P. Stolk, J.G. Rosmalen, D.S. Postma, R.A. de Boer, G. Navis, J.P. Slaets, J. Ormel, and B.H. Wolffenbuttel Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study Eur. J. Epidemiol. 23 2008 67 74
30. L.D. Ward, and M. Kellis HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants Nucleic Acids Res. 40 D1 2012 D930 D934
31. K. Wang, M. Li, and H. Hakonarson ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data Nucleic Acids Res. 38 2010 e164
32. A.P. Boyle, E.L. Hong, M. Hariharan, Y. Cheng, M.A. Schaub, M. Kasowski, K.J. Karczewski, J. Park, B.C. Hitz, and S. Weng et al. Annotation of functional variation in personal genomes using RegulomeDB Genome Res. 22 2012 1790 1797
33. B.E. Bernstein, E. Birney, I. Dunham, E.D. Green, C. Gunter, M. Snyder ENCODE Project Consortium An integrated encyclopedia of DNA elements in the human genome Nature 489 2012 57 74
34. Y.I. Liu, P.H. Wise, and A.J. Butte The "etiome": identification and clustering of human disease etiological factors BMC Bioinformatics 10 Suppl 2 2009 S14
35. P.J. Talmud, F. Drenos, S. Shah, T. Shah, J. Palmen, C. Verzilli, T.R. Gaunt, J. Pallas, R. Lovering, K. Li ASCOT investigators NORDIL investigators BRIGHT Consortium Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip Am. J. Hum. Genet. 85 2009 628 642
36. S. Ekins, J. Mestres, and B. Testa In silico pharmacology for drug discovery: applications to targets and beyond Br. J. Pharmacol. 152 2007 21 37
37. A. Volkamer, D. Kuhn, T. Grombacher, F. Rippmann, and M. Rarey Combining global and local measures for structure-based druggability predictions J. Chem. Inf. Model. 52 2012 360 372
38. H.H. Göring, J.E. Curran, M.P. Johnson, T.D. Dyer, J. Charlesworth, S.A. Cole, J.B. Jowett, L.J. Abraham, D.L. Rainwater, and A.G. Comuzzie et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes Nat. Genet. 39 2007 1208 1216
39. Y. Idaghdour, W. Czika, K.V. Shianna, S.H. Lee, P.M. Visscher, H.C. Martin, K. Miclaus, S.J. Jadallah, D.B. Goldstein, R.D. Wolfinger, and G. Gibson Geographical genomics of human leukocyte gene expression variation in southern Morocco Nat. Genet. 42 2010 62 67
40. V. Emilsson, G. Thorleifsson, B. Zhang, A.S. Leonardson, F. Zink, J. Zhu, S. Carlson, A. Helgason, G.B. Walters, and S. Gunnarsdottir et al. Genetics of gene expression and its effect on disease Nature 452 2008 423 428
41. R.S. Fehrmann, R.C. Jansen, J.H. Veldink, H.J. Westra, D. Arends, M.J. Bonder, J. Fu, P. Deelen, H.J. Groen, and A. Smolonska et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA PLoS Genet. 7 2011 e1002197
42. D. Mehta, K. Heim, C. Herder, M. Carstensen, G. Eckstein, C. Schurmann, G. Homuth, M. Nauck, U. Völker, and M. Roden et al. Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood Eur. J. Hum. Genet. 21 2013 48 54
43. D. Sasayama, H. Hori, S. Nakamura, R. Miyata, T. Teraishi, K. Hattori, M. Ota, N. Yamamoto, T. Higuchi, N. Amano, and H. Kunugi Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population PLoS ONE 8 2013 e54967
44. A.L. Dixon, L. Liang, M.F. Moffatt, W. Chen, S. Heath, K.C. Wong, J. Taylor, E. Burnett, I. Gut, and M. Farrall et al. A genome-wide association study of global gene expression Nat. Genet. 39 2007 1202 1207
45. L. Liang, N. Morar, A.L. Dixon, G.M. Lathrop, G.R. Abecasis, M.F. Moffatt, and W.O. Cookson A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines Genome Res. 23 2013 716 726
46. B.E. Stranger, A.C. Nica, M.S. Forrest, A. Dimas, C.P. Bird, C. Beazley, C.E. Ingle, M. Dunning, P. Flicek, and D. Koller et al. Population genomics of human gene expression Nat. Genet. 39 2007 1217 1224
47. T. Kwan, D. Benovoy, C. Dias, S. Gurd, C. Provencher, P. Beaulieu, T.J. Hudson, R. Sladek, and J. Majewski Genome-wide analysis of transcript isoform variation in humans Nat. Genet. 40 2008 225 231
48. A.S. Dimas, S. Deutsch, B.E. Stranger, S.B. Montgomery, C. Borel, H. Attar-Cohen, C. Ingle, C. Beazley, M. Gutierrez Arcelus, and M. Sekowska et al. Common regulatory variation impacts gene expression in a cell type-dependent manner Science 325 2009 1246 1250
49. D.A. Cusanovich, C. Billstrand, X. Zhou, C. Chavarria, S. De Leon, K. Michelini, A.A. Pai, C. Ober, and Y. Gilad The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes Hum. Mol. Genet. 21 2012 2111 2123
50. E. Grundberg, K.S. Small, A.K. Hedman, A.C. Nica, A. Buil, S. Keildson, J.T. Bell, T.P. Yang, E. Meduri, A. Barrett Multiple Tissue Human Expression Resource (MuTHER) Consortium Mapping cis- and trans-regulatory effects across multiple tissues in twins Nat. Genet. 44 2012 1084 1089
51. L.M. Mangravite, B.E. Engelhardt, M.W. Medina, J.D. Smith, C.D. Brown, D.I. Chasman, B.H. Mecham, B. Howie, H. Shim, and D. Naidoo et al. A statin-dependent QTL for GATM expression is associated with statin-induced myopathy Nature 502 2013 377 380
52. B.P. Fairfax, S. Makino, J. Radhakrishnan, K. Plant, S. Leslie, A. Dilthey, P. Ellis, C. Langford, F.O. Vannberg, and J.C. Knight Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles Nat. Genet. 44 2012 502 510
53. A. Murphy, J.H. Chu, M. Xu, V.J. Carey, R. Lazarus, A. Liu, S.J. Szefler, R. Strunk, K. Demuth, and M. Castro et al. Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes Hum. Mol. Genet. 19 2010 4745 4757
54. E.L. Heinzen, D. Ge, K.D. Cronin, J.M. Maia, K.V. Shianna, W.N. Gabriel, K.A. Welsh-Bohmer, C.M. Hulette, T.N. Denny, and D.B. Goldstein Tissue-specific genetic control of splicing: implications for the study of complex traits PLoS Biol. 6 2008 e1
55. T. Zeller, P. Wild, S. Szymczak, M. Rotival, A. Schillert, R. Castagne, S. Maouche, M. Germain, K. Lackner, and H. Rossmann et al. Genetics and beyond - the transcriptome of human monocytes and disease susceptibility PLoS ONE 5 2010 e10693
56. L.B. Barreiro, L. Tailleux, A.A. Pai, B. Gicquel, J.C. Marioni, and Y. Gilad Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection Proc. Natl. Acad. Sci. USA 109 2012 1204 1209
57. D.M. Greenawalt, R. Dobrin, E. Chudin, I.J. Hatoum, C. Suver, J. Beaulaurier, B. Zhang, V. Castro, J. Zhu, and S.K. Sieberts et al. A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort Genome Res. 21 2011 1008 1016
58. K.S. Kompass, and J.S. Witte Co-regulatory expression quantitative trait loci mapping: method and application to endometrial cancer BMC Med. Genomics 4 2011 6
59. Q. Li, J.H. Seo, B. Stranger, A. McKenna, I. Pe'er, T. Laframboise, M. Brown, S. Tyekucheva, and M.L. Freedman Integrative eQTL-based analyses reveal the biology of breast cancer risk loci Cell 152 2013 633 641
60. J.A. Webster, J.R. Gibbs, J. Clarke, M. Ray, W. Zhang, P. Holmans, K. Rohrer, A. Zhao, L. Marlowe, M. Kaleem NACC-Neuropathology Group Genetic control of human brain transcript expression in Alzheimer disease Am. J. Hum. Genet. 84 2009 445 458
61. F. Zou, H.S. Chai, C.S. Younkin, M. Allen, J. Crook, V.S. Pankratz, M.M. Carrasquillo, C.N. Rowley, A.A. Nair, S. Middha Alzheimer's Disease Genetics Consortium Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants PLoS Genet. 8 2012 e1002707
62. C. Colantuoni, B.K. Lipska, T. Ye, T.M. Hyde, R. Tao, J.T. Leek, E.A. Colantuoni, A.G. Elkahloun, M.M. Herman, D.R. Weinberger, and J.E. Kleinman Temporal dynamics and genetic control of transcription in the human prefrontal cortex Nature 478 2011 519 523
63. C. Liu, L. Cheng, J.A. Badner, D. Zhang, D.W. Craig, M. Redman, and E.S. Gershon Whole-genome association mapping of gene expression in the human prefrontal cortex Mol. Psychiatry 15 2010 779 784
64. J.R. Gibbs, M.P. van der Brug, D.G. Hernandez, B.J. Traynor, M.A. Nalls, S.L. Lai, S. Arepalli, A. Dillman, I.P. Rafferty, and J. Troncoso et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain PLoS Genet. 6 2010 e1000952
65. B. Zhang, C. Gaiteri, L.-G. Bodea, Z. Wang, J. McElwee, A.A. Podtelezhnikov, C. Zhang, T. Xie, L. Tran, and R. Dobrin et al. Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease Cell 153 2013 707 720
66. E.E. Schadt, C. Molony, E. Chudin, K. Hao, X. Yang, P.Y. Lum, A. Kasarskis, B. Zhang, S. Wang, and C. Suver et al. Mapping the genetic architecture of gene expression in human liver PLoS Biol. 6 2008 e107
67. F. Innocenti, G.M. Cooper, I.B. Stanaway, E.R. Gamazon, J.D. Smith, S. Mirkov, J. Ramirez, W. Liu, Y.S. Lin, and C. Moloney et al. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue PLoS Genet. 7 2011 e1002078
68. E. Grundberg, T. Kwan, B. Ge, K.C. Lam, V. Koka, A. Kindmark, H. Mallmin, J. Dias, D.J. Verlaan, and M. Ouimet et al. Population genomics in a disease targeted primary cell model Genome Res. 19 2009 1942 1952
69. B. Kabakchiev, and M.S. Silverberg Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine Gastroenterology 144 2013 1488 1496 e1-e3
70. K. Hao, Y. Bossé, D.C. Nickle, P.D. Paré, D.S. Postma, M. Laviolette, A. Sandford, T.L. Hackett, D. Daley, and J.C. Hogg et al. Lung eQTLs to help reveal the molecular underpinnings of asthma PLoS Genet. 8 2012 e1003029
71. J. Ding, J.E. Gudjonsson, L. Liang, P.E. Stuart, Y. Li, W. Chen, M. Weichenthal, E. Ellinghaus, A. Franke, and W. Cookson et al. Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals Am. J. Hum. Genet. 87 2010 779 789
72. R.S. Huang, E.R. Gamazon, D. Ziliak, Y. Wen, H.K. Im, W. Zhang, C. Wing, S. Duan, W.K. Bleibel, N.J. Cox, and M.E. Dolan Population differences in microRNA expression and biological implications RNA Biol. 8 2011 692 701
73. M. Rantalainen, B.M. Herrera, G. Nicholson, R. Bowden, Q.F. Wills, J.L. Min, M.J. Neville, A. Barrett, M. Allen, and N.W. Rayner et al. MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven PLoS ONE 6 2011 e27338
74. C. Newton-Cheh, M.G. Larson, R.S. Vasan, D. Levy, K.D. Bloch, A. Surti, C. Guiducci, S. Kathiresan, E.J. Benjamin, and J. Struck et al. Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure Nat. Genet. 41 2009 348 353
75. E. Salvi, Z. Kutalik, N. Glorioso, P. Benaglio, F. Frau, T. Kuznetsova, H. Arima, C. Hoggart, J. Tichet, and Y.P. Nikitin et al. Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase Hypertension 59 2012 248 255
76. L.V. Wain, G.C. Verwoert, P.F. O'Reilly, G. Shi, T. Johnson, A.D. Johnson, M. Bochud, K.M. Rice, P. Henneman, A.V. Smith LifeLines Cohort Study EchoGen consortium AortaGen Consortium CHARGE Consortium Heart Failure Working Group KidneyGen consortium CKDGen consortium Cardiogenics consortium CardioGram Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure Nat. Genet. 43 2011 1005 1011
77. S. Padmanabhan, O. Melander, T. Johnson, A.M. Di Blasio, W.K. Lee, D. Gentilini, C.E. Hastie, C. Menni, M.C. Monti, C. Delles Global BPgen Consortium Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension PLoS Genet. 6 2010 e1001177
78. F.R. Giachini, V.V. Lima, F.S. Carneiro, R.C. Tostes, and R.C. Webb Decreased cGMP level contributes to increased contraction in arteries from hypertensive rats: role of phosphodiesterase 1 Hypertension 57 2011 655 663
79. R.T. Schermuly, S.S. Pullamsetti, G. Kwapiszewska, R. Dumitrascu, X. Tian, N. Weissmann, H.A. Ghofrani, C. Kaulen, T. Dunkern, and C. Schudt et al. Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy Circulation 115 2007 2331 2339
80. F. Zhu, Y. Sun, M. Wang, S. Ma, X. Chen, A. Cao, F. Chen, Y. Qiu, and Y. Liao Correlation between HLA-DRB1, HLA-DQB1 polymorphism and autoantibodies against angiotensin AT(1) receptors in Chinese patients with essential hypertension Clin. Cardiol. 34 2011 302 308
81. A. Köttgen, E. Albrecht, A. Teumer, V. Vitart, J. Krumsiek, C. Hundertmark, G. Pistis, D. Ruggiero, C.M. O'Seaghdha, T. Haller LifeLines Cohort Study CARDIoGRAM Consortium DIAGRAM Consortium ICBP Consortium MAGIC Consortium Genome-wide association analyses identify 18 new loci associated with serum urate concentrations Nat. Genet. 45 2013 145 154
82. A. Köttgen, C. Pattaro, C.A. Böger, C. Fuchsberger, M. Olden, N.L. Glazer, A. Parsa, X. Gao, Q. Yang, and A.V. Smith et al. New loci associated with kidney function and chronic kidney disease Nat. Genet. 42 2010 376 384
83. M.H. Gollob, M.S. Green, A.S. Tang, T. Gollob, A. Karibe, A.S. Ali Hassan, F. Ahmad, R. Lozado, G. Shah, and L. Fananapazir et al. Identification of a gene responsible for familial Wolff-Parkinson-White syndrome N. Engl. J. Med. 344 2001 1823 1831
84. M. Arad, B.J. Maron, J.M. Gorham, W.H. Johnson Jr., J.P. Saul, A.R. Perez-Atayde, P. Spirito, G.B. Wright, R.J. Kanter, C.E. Seidman, and J.G. Seidman Glycogen storage diseases presenting as hypertrophic cardiomyopathy N. Engl. J. Med. 352 2005 362 372
85. P. van der Harst, W. Zhang, I. Mateo Leach, A. Rendon, N. Verweij, J. Sehmi, D.S. Paul, U. Elling, H. Allayee, and X. Li et al. Seventy-five genetic loci influencing the human red blood cell Nature 492 2012 369 375
86. S.K. Ganesh, N.A. Zakai, F.J. van Rooij, N. Soranzo, A.V. Smith, M.A. Nalls, M.H. Chen, A. Kottgen, N.L. Glazer, and A. Dehghan et al. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium Nat. Genet. 41 2009 1191 1198
87. J.T. Powell, R.J. Turner, A.M. Henney, G.J. Miller, and S.E. Humphries An association between arterial pulse pressure and variation in the fibrillin-1 gene Heart 78 1997 396 398
88. T.L. Medley, T.J. Cole, C.D. Gatzka, W.Y.S. Wang, A.M. Dart, and B.A. Kingwell Fibrillin-1 genotype is associated with aortic stiffness and disease severity in patients with coronary artery disease Circulation 105 2002 810 815
89. S.A. Lemaire, M.-L.N. McDonald, D.C. Guo, L. Russell, C.C. Miller 3rd, R.J. Johnson, M.R. Bekheirnia, L.M. Franco, M. Nguyen, and R.E. Pyeritz et al. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1 Nat. Genet. 43 2011 996 1000
90. G. Lettre, A.U. Jackson, C. Gieger, F.R. Schumacher, S.I. Berndt, S. Sanna, S. Eyheramendy, B.F. Voight, J.L. Butler, C. Guiducci Diabetes Genetics Initiative FUSION KORA Prostate, Lung Colorectal and Ovarian Cancer Screening Trial Nurses' Health Study SardiNIA Identification of ten loci associated with height highlights new biological pathways in human growth Nat. Genet. 40 2008 584 591
91. H. Lango Allen, K. Estrada, G. Lettre, S.I. Berndt, M.N. Weedon, F. Rivadeneira, C.J. Willer, A.U. Jackson, S. Vedantam, and S. Raychaudhuri et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height Nature 467 2010 832 838
92. S.I. Berndt, S. Gustafsson, R. Mägi, A. Ganna, E. Wheeler, M.F. Feitosa, A.E. Justice, K.L. Monda, D.C. Croteau-Chonka, and F.R. Day et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture Nat. Genet. 45 2013 501 512
93. Y. Kamatani, K. Matsuda, Y. Okada, M. Kubo, N. Hosono, Y. Daigo, Y. Nakamura, and N. Kamatani Genome-wide association study of hematological and biochemical traits in a Japanese population Nat. Genet. 42 2010 210 215
94. Y. Okada, T. Hirota, Y. Kamatani, A. Takahashi, H. Ohmiya, N. Kumasaka, K. Higasa, Y. Yamaguchi-Kabata, N. Hosono, and M.A. Nalls et al. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population PLoS Genet. 7 2011 e1002067
95. A.P. Reiner, G. Lettre, M.A. Nalls, S.K. Ganesh, R. Mathias, M.A. Austin, E. Dean, S. Arepalli, A. Britton, and Z. Chen et al. Genome-wide association study of white blood cell count in 16,388 African Americans: The continental origins and genetic epidemiology network (COGENT) PLoS Genet. 7 2011 e1002108
96. W. Xu, H. Baribault, and E.D. Adamson Vinculin knockout results in heart and brain defects during embryonic development Development 125 1998 327 337
97. L. Yu, M. Chen, D. Zhao, P. Yi, L. Lu, J. Han, X. Zheng, Y. Zhou, and L. Li The H19 gene imprinting in normal pregnancy and pre-eclampsia Placenta 30 2009 443 447
98. A. Sparago, F. Cerrato, M. Vernucci, G.B. Ferrero, M.C. Silengo, and A. Riccio Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome Nat. Genet. 36 2004 958 960
99. J. Bliek, P. Terhal, M.-J. van den Bogaard, S. Maas, B. Hamel, G. Salieb-Beugelaar, M. Simon, T. Letteboer, J. van der Smagt, H. Kroes, and M. Mannens Hypomethylation of the H19 gene causes not only Silver-Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype Am. J. Hum. Genet. 78 2006 604 614
100. T. Angelone, E. Filice, T. Pasqua, N. Amodio, M. Galluccio, G. Montesanti, A.M. Quintieri, and M.C. Cerra Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury Cell. Mol. Life Sci. 70 2013 495 509
101. A. Islam, B. Adamik, F.I. Hawari, G. Ma, F.N. Rouhani, J. Zhang, and S.J. Levine Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex J. Biol. Chem. 281 2006 6860 6873
102. S. Oh-I, H. Shimizu, T. Satoh, S. Okada, S. Adachi, K. Inoue, H. Eguchi, M. Yamamoto, T. Imaki, and K. Hashimoto et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus Nature 443 2006 709 712
103. Y. Kokubo, H. Tomoike, C. Tanaka, M. Banno, T. Okuda, N. Inamoto, K. Kamide, Y. Kawano, and T. Miyata Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension Hypertens. Res. 29 2006 611 619
104. J.P. Cardinale, S. Sriramula, N. Mariappan, D. Agarwal, and J. Francis Angiotensin II-induced hypertension is modulated by nuclear factor-κB in the paraventricular nucleus Hypertension 59 2012 113 121
105. N. Franceschini, E. Fox, Z. Zhang, T.L. Edwards, M.A. Nalls, Y.J. Sung, B.O. Tayo, Y.V. Sun, O. Gottesman, A. Adeyemo Asian Genetic Epidemiology Network Consortium Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations Am. J. Hum. Genet. 93 2013 545 554
106. J.A. Halterman, H.M. Kwon, R. Zargham, P.D. Bortz, and B.R. Wamhoff Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation Arterioscler. Thromb. Vasc. Biol. 31 2011 2287 2296
107. J.A. Halterman, H.M. Kwon, N. Leitinger, and B.R. Wamhoff NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration Front. Physiol. 3 2012 313
108. C.E. Elks, J.R. Perry, P. Sulem, D.I. Chasman, N. Franceschini, C. He, K.L. Lunetta, J.A. Visser, E.M. Byrne, D.L. Cousminer GIANT Consortium Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies Nat. Genet. 42 2010 1077 1085
109. Y.-H. Kim, J.H. Hwang, J.-R. Noh, G.-T. Gang, H. Kim, H.Y. Son, T.H. Kwak, M. Shong, I.K. Lee, and C.H. Lee Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity Cardiovasc. Res. 91 2011 519 527
110. F.J. McDonald, A.H. Western, J.D. McNeil, B.C. Thomas, D.R. Olson, and P.M. Snyder Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel Am. J. Physiol. Renal Physiol. 283 2002 F431 F436
111. S.D. Persell Prevalence of resistant hypertension in the United States, 2003-2008 Hypertension 57 2011 1076 1080
112. B. Cvek, and Z. Dvorak Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals Curr. Pharm. Des. 13 2007 3155 3167
113. P. Dranchak, R. MacArthur, R. Guha, W.J. Zuercher, D.H. Drewry, D.S. Auld, and J. Inglese Profile of the GSK published protein kinase inhibitor set across ATP-dependent and-independent luciferases: implications for reporter-gene assays PLoS ONE 8 2013 e57888
114. C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 46 2001 3 26